keyword
MENU ▼
Read by QxMD icon Read
search

surfactant in prematurity babies

keyword
https://www.readbyqxmd.com/read/27545716/preventing-newborn-deaths-due-to-prematurity
#1
Kishwar Azad, Jiji Mathews
Preterm births (PTBs), defined as births before 37 weeks of gestation account for the majority of deaths in the newborn period. Prediction and prevention of PTB is challenging. A history of preterm labour or second trimester losses and accurate measurement of cervical length help to identify women who would benefit from progesterone and cerclage. Fibronectin estimation in the cervicovaginal secretions of a symptomatic woman with an undilated cervix can predict PTB within 10 days of testing. Antibiotics should be given to women with preterm prelabour rupture of membranes but tocolysis has a limited role in the management of preterm labour...
June 24, 2016: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/27424553/tracheal-agenesis-a-report-of-two-cases
#2
A V Desai, Sudha Rao, P R Shanbhag, M Rupani
Tracheal agenesis is an extremely rare congenital anomaly involving the respiratory system. It is generally associated with anomalies of other systems. Antenatal diagnosis of this condition is difficult; therefore, it presents as a medical emergency in the labor room. Intubation in these babies is difficult. As many of these babies are born prematurely, respiratory distress syndrome (RDS) adds to the management difficulties. Here, we describe two babies with this lethal anomaly and RDS where esophageal intubation and surfactant therapy proved beneficial...
July 2016: Journal of Postgraduate Medicine
https://www.readbyqxmd.com/read/26958689/strategies-of-using-surfactant-results-of-the-first-polish-national-survey-of-daily-practice
#3
Maria Katarzyna Borszewska-Kornacka, Marzena Kostuch, Piotr Korbal, Paweł Krajewski
BACKGROUND: The efficiency of routine practices in the management of neonatal respiratory distress syndrome (RDS) have never been systematically investigated in Poland. OBJECTIVE: To evaluate RDS treatment policies and short-term outcomes in neonatal intensive care units (NICUs). MATERIAL AND METHODS: We retrospectively analyzed medical records of premature neonates ≤ 32 weeks' gestation, diagnosed with RDS in level-2 and level-3 referral centers...
July 2015: Developmental Period Medicine
https://www.readbyqxmd.com/read/26733541/stabilisation-of-premature-infants-in-the-delivery-room-with-nasal-high-flow
#4
Peter Reynolds, Stamatina Leontiadi, Tracy Lawson, Tosin Otunla, Olayinka Ejiwumi, Nicola Holland
OBJECTIVE: This was a pilot study to determine the feasibility of using nasal high flow (nHF) (also known as heated humidified high-flow nasal cannula) for stabilisation of babies born at <30 weeks gestation in the delivery room (DR) and transfer to the neonatal intensive care unit (NICU). DESIGN: Observational study. SETTING: Single-centre NICU. PATIENTS: Infants born at <30 weeks gestation. INTERVENTIONS: Stabilisation and transfer to NICU using nHF...
July 2016: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/25885964/a-pilot-study-of-less-invasive-surfactant-administration-in-very-preterm-infants-in-a-chinese-tertiary-center
#5
RANDOMIZED CONTROLLED TRIAL
Yingying Bao, Guolian Zhang, Mingyuan Wu, Lixin Ma, Jiajun Zhu
BACKGROUND: Less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce the duration of mechanical ventilation and the incidence of bronchopulmonary dysplasia (BPD) in previous study. The objective of this study was to explore the feasibility and potential benefits of LISA in early preterm infants on nasal continuous positive airway pressure (nCPAP) compared to conventional endotracheal instillation. METHODS: All infants with respiratory distress born at 28-32 weeks' gestational age from January 2012 to December 2012 (n=90), who were eligible for exogenous pulmonary surfactant (PS) therapy were randomized to receive PS by intubation with an endotracheal tube (Intubation group, n=43), or by intubation using a catheter while on nCPAP (LISA group, n=47)...
2015: BMC Pediatrics
https://www.readbyqxmd.com/read/25777608/a-pilot-study-of-less-invasive-surfactant-administration-in-very-preterm-infants-in-a-chinese-tertiary-center
#6
Yingying Bao, Guolian Zhang, Mingyuan Wu, Lixin Ma, Jiajun Zhu
BACKGROUND: Less invasive surfactant administration (LISA) to spontaneously breathing preterm infants has been reported to reduce the duration of mechanical ventilation and the incidence of bronchopulmonary dysplasia (BPD) in previous study. The objective of this study was to explore the feasibility and potential benefits of LISA in early preterm infants on nasal continuous positive airway pressure (nCPAP) compared to conventional endotracheal instillation. METHODS: All infants with respiratory distress born at 28-32 weeks' gestational age from January 2012 to December 2012 (n=90), who were eligible for exogenous pulmonary surfactant (PS) therapy were randomized to receive PS by intubation with an endotracheal tube (Intubation group, n=43), or by intubation using a catheter while on nCPAP (LISA group, n=47)...
December 2015: BMC Pediatrics
https://www.readbyqxmd.com/read/25683992/efficacy-of-surfactant-ta-calfactant-and-poractant-alfa-for-preterm-infants-with-respiratory-distress-syndrome-a-retrospective-study
#7
COMPARATIVE STUDY
Ga Won Jeon, Minkyung Oh, Jong Beom Sin
PURPOSE: To compare the efficacy of the new drug calfactant with the commonly used drugs surfactant-TA and poractant alfa. MATERIALS AND METHODS: A total of 332 preterm infants at 24-31 weeks' gestation with respiratory distress syndrome (RDS) were enrolled and allocated to three groups according to the surfactant instilled; Group 1 (n=146, surfactant-TA), Group 2 (n=96, calfactant), and Group 3 (n=90, poractant alfa). The diagnosis of RDS and the decision to replace the pulmonary surfactant were left to the attending physician and based on patient severity determined by chest radiography and blood gas analysis...
March 2015: Yonsei Medical Journal
https://www.readbyqxmd.com/read/25530316/support-and-the-ethics-of-study-implementation-lessons-for-comparative-effectiveness-research-from-the-trial-of-oxygen-therapy-for-premature-babies
#8
John D Lantos, Chris Feudtner
The design of SUPPORT has been widely misunderstood. This confusion has driven much of the debate about the trial - and threatens the whole enterpise of comparative effectiveness research.
January 2015: Hastings Center Report
https://www.readbyqxmd.com/read/25456299/universal-cranial-ultrasound-screening-in-preterm-infants-with-gestational-age-33-36-weeks-a-retrospective-analysis-of-724-newborns
#9
Elisa Ballardini, Anna Tarocco, Alessandro Baldan, Elisa Antoniazzi, Giampaolo Garani, Caterina Borgna-Pignatti
BACKGROUND: Cranial ultrasonography is a useful tool to detect intracranial lesions in premature neonates at risk. Our primary aim was to determine the number of patients with abnormal cranial ultrasonography. Secondary aims were to evaluate the usefulness of universal cranial ultrasonography screening in moderately preterm infants. METHODS: All infants born from 2007 to 2012 at the University Hospital of Ferrara (Italy), with gestational age of 33-36 weeks, were included in the study...
December 2014: Pediatric Neurology
https://www.readbyqxmd.com/read/24931328/ethical-pitfalls-in-neonatal-comparative-effectiveness-trials
#10
Neena Modi
Evidence-based medicine has been embraced wholeheartedly, and rightly so, as the best approach for reducing clinical uncertainty and ensuring that patients receive treatment and care that are efficacious (i.e. they work) and effective (i.e. they work in real life). High-quality evidence comes from high-quality clinical research. It would hence be reasonable to assume that these two would form a closely integrated partnership. Alas, this is not yet the case. So many uncertainties in medical care relate to treatments and practices already widely in use...
2014: Neonatology
https://www.readbyqxmd.com/read/24796503/improvement-of-pulmonary-surfactant-activity-by-introducing-d-amino-acids-into-highly-hydrophobic-amphiphilic-%C3%AE-peptide-hel-13-5
#11
Yoshihiro Nakamura, Ko Yukitake, Hiromichi Nakahara, Sooyoung Lee, Osamu Shibata, Sannamu Lee
The high costs of artificial pulmonary surfactants, ranging in hundreds per kilogram of body weight, used for treating the respiratory distress syndrome (RDS) premature babies have limited their applications. We have extensively studied soy lecithins and higher alcohols as lipid alternatives to expensive phospholipids such as DPPC and PG. As a substitute for the proteins, we have synthesized the peptide Hel 13-5D3 by introducing D-amino acids into a highly lipid-soluble, basic amphiphilic peptide, Hel 13-5, composed of 18 amino acid residues...
August 2014: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/24335141/type-i-and-ii-pneumocyte-differentiation-in-the-developing-fetal-chicken-lung-conservation-of-pivotal-proteins-from-birds-to-human-in-the-struggle-for-life-at-birth
#12
Sigrid Bjørnstad, Ragnhild E Paulsen, Aage Erichsen, Joel C Glover, Borghild Roald
BACKGROUND: Antenatal corticosteroids and surfactant replacement therapy have dramatically reduced mortality caused by lung disease in premature babies. Knowledge about mechanisms regulating epithelial differentiation of the respiratory membrane is limited, as are effects of pharmacological interventions. The chicken fetus is a valuable model for exploring pharmacological actions on developing organs. However, more precise information about the timing of developmental events in the chicken lung is needed for human correlation...
2014: Neonatology
https://www.readbyqxmd.com/read/24297389/antibiotics-for-preterm-rupture-of-membranes
#13
REVIEW
Sara Kenyon, Michel Boulvain, James P Neilson
BACKGROUND: Premature birth carries substantial neonatal morbidity and mortality. Subclinical infection is associated with preterm rupture of membranes (PROM). Prophylactic maternal antibiotic therapy might lessen infectious morbidity and delay labour, but could suppress labour without treating underlying infection. OBJECTIVES: To evaluate the immediate and long-term effects of administering antibiotics to women with PROM before 37 weeks, on maternal infectious morbidity, neonatal morbidity and mortality, and longer-term childhood development...
2013: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/24140977/calcium-signaling-related-proteins-are-associated-with-broncho-pulmonary-dysplasia-progression
#14
Cinzia Magagnotti, Piero Giuseppe Matassa, Angela Bachi, Valentina Vendettuoli, Isabella Fermo, Maria Rosa Colnaghi, Rose Mary Carletti, Domenica Mercadante, Elena Fattore, Fabio Mosca, Annapaola Andolfo
UNLABELLED: Broncho-pulmonary dysplasia (BPD) is a chronic pulmonary disorder that follows premature birth. It is preceded by respiratory distress syndrome (RDS), characterized by acute respiratory failure due to deficiency of surfactant at birth. Clinical characteristics of infants affected by BPD have widely changed in the last decades: they are extraordinarly immature, with impaired alveolar and vascular lung development. To build up new therapeutic strategies for BPD babies, it is necessary to understand the pathogenic mechanisms, which are complicated by environmental risk factors and genetic predisposition...
December 6, 2013: Journal of Proteomics
https://www.readbyqxmd.com/read/24113118/-ante-natal-corticosteroids-and-prevention-of-respiratory-distress-in-the-premature-newborn-usefulness-of-rescue-treatment
#15
O López-Suárez, C García-Magán, R Saborido-Fiaño, A Pérez-Muñuzuri, A Baña-Souto, M L Couce-Pico
The effectiveness of antenatal corticosteroid therapy for foetal lung maturation in pre-term infants is well known, but there is uncertainty about the time that the treatment remains effective. A descriptive, longitudinal study was conducted to determine whether the need for surfactant administration was determined by the time-lapse between corticosteroids administration and delivery, and when repeating the doses of maternal corticosteroids should be considered. A total of 91 premature infants ≤32 weeks and/or ≤1,500 g (limit 34+6 weeks) whose mothers had received a complete course of corticosteroids were included...
August 2014: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/24075206/less-invasive-surfactant-administration-lisa-ways-to-deliver-surfactant-in-spontaneously-breathing-infants
#16
Egbert Herting
The idea to deliver surfactant to spontaneously breathing premature infants is not new. The spectrum of methods reported reaches from aerosol administration over pharyngeal deposition, the use of laryngeal masks, short term intubation, surfactant administration and rapid extubation (INSURE) to an approach of keeping premature neonates on spontaneous breathing with continuous positive airway pressure support and administering surfactant by laryngoscopy via a small diameter tube. This way of Less Invasive Surfactant Administration (LISA) is in increasing use in the last decade in Germany...
November 2013: Early Human Development
https://www.readbyqxmd.com/read/23942744/heated-humidified-high-flow-nasal-cannula-versus-low-flow-nasal-cannula-as-weaning-mode-from-nasal-cpap-in-infants-%C3%A2-28-weeks-of-gestation
#17
Jose Ramon Fernandez-Alvarez, Rashmi Shreyans Gandhi, Philip Amess, Liam Mahoney, Ryan Watkins, Heike Rabe
UNLABELLED: Despite the paucity of evidence, the practice of weaning nasal continuous positive airway pressure (NCPAP) is widespread. However, the most clinically effective non-invasive ventilatory support strategy remains to be determined. We compared the outcome of very premature infants with respiratory distress syndrome treated with a combination of NCPAP and heated humidified high-flow nasal cannula (HHFNC) versus NCPAP and low-flow nasal cannula (LFNC). Between 2004 and 2008, patients ≤28 weeks of gestation and <1,250 g of birth weight were treated with NCPAP + HHFNC or NCPAP + LFNC...
January 2014: European Journal of Pediatrics
https://www.readbyqxmd.com/read/23937654/perinatal-factors-in-patent-ductus-arteriosus-in-very-low-birthweight-infants
#18
COMPARATIVE STUDY
Ying-Yao Chen, Hsiao-Ping Wang, Jenn-Tzong Chang, Yee-Hsuan Chiou, Yung-Feng Huang, Kai-Sheng Hsieh
BACKGROUND: The relationship between hemoglobin and patent ductus arteriosus (PDA) has not been discussed before. The aim of this study was to assess the influence of hemoglobin and perinatal factors on PDA in very low-birthweight (VLBW) infants. METHODS: Using data from the Premature Baby Foundation of Taiwan (PBFA), the characteristics, perinatal factors, and hemoglobin of VLBW infants with and without PDA and treatment were compared. RESULTS: Between January 2008 and December 2010, 89 VLBW infants were admitted to hospital...
February 2014: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/23809343/surfactant-therapy-past-present-and-future
#19
REVIEW
Christian P Speer, David G Sweet, Henry L Halliday
Surfactant replacement in preterm infants with respiratory distress syndrome (RDS) has been a major therapeutic breakthrough and the most intensively studied intervention in neonatal medicine. Surfactant whether given prophylactically in the delivery room or in babies with established RDS reduces the severity of RDS, the incidence of air leaks and pneumothorax and, most importantly, neonatal death. Many randomized controlled trials have explored different strategies to optimize the effect of surfactant administration and have further improved neonatal outcome...
June 2013: Early Human Development
https://www.readbyqxmd.com/read/23802801/poractant-alfa-versus-beractant-for-respiratory-distress-syndrome-in-preterm-infants-a-retrospective-cohort-study
#20
COMPARATIVE STUDY
Saritha Paul, Shripada Rao, Rolland Kohan, Judy McMichael, Noel French, Guicheng Zhang, Karen Simmer
AIM: Poractant alfa and beractant are the commonly used animal derived surfactants in preterm infants with respiratory distress syndrome. Between 2005 and 2007, poractant alfa and beractant were alternated every month in our neonatal intensive care unit for 27 months. The aim of this study was to compare the outcomes of preterm infants who received poractant alfa versus beractant. METHOD: Single-centre, retrospective cohort study of inborn preterm infants <32 weeks gestation (23-31(+6) )...
October 2013: Journal of Paediatrics and Child Health
keyword
keyword
46664
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"