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https://www.readbyqxmd.com/read/29783959/soluble-urokinase-plasminogen-activator-receptor-predicts-mortality-in-exacerbated-copd
#1
Nina S Godtfredsen, Ditte V Jørgensen, Kristoffer Marsaa, Charlotte S Ulrik, Ove Andersen, Jesper Eugen-Olsen, Line J H Rasmussen
BACKGROUND: The inflammatory biomarker soluble urokinase plasminogen activator receptor (suPAR) is elevated in severe acute and chronic medical conditions and has been associated with short-term mortality. The role of suPAR in predicting risk of death following an acute exacerbation of chronic obstructive pulmonary disease (AECOPD) has never been studied. We hypothesized that increased suPAR is an independent predictor of short-term mortality in patients admitted to hospital with COPD or acute respiratory failure...
May 21, 2018: Respiratory Research
https://www.readbyqxmd.com/read/29775445/the-clinical-pattern-of-nephrotic-syndrome-in-children-has-no-effect-on-the-concentration-of-soluble-urokinase-receptor-supar-in-serum-and-urine
#2
Agnieszka Ochocińska, Wioletta Jarmużek, Roman Janas
Concentration of soluble urokinase receptor (suPAR) was regarded as viable marker to differentiate the focal segmental glomerulosclerosis (FSGS) from other glomerulopathies and also as predictive parameter for progression of renal disease. AIM: The aim of this study was to evaluate serum and urine (s)(u)suPAR concentration in steroid-sensitive and steroid-resistant nephrotic children treated with different (double and triple-drug) regimens. MATERIALS AND METHODS: Overall 43 children were evaluated including 14 patients with steroid-resistant nephrotic syndrome (SRNS) aged 9±6 years and 29 with steroid-sensitive nephrotic syndrome (SSNS) aged 9±5 years, as well as control group (n=59)...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29760745/diagnostic-value-of-decoy-receptor-3-combined-with-procalcitonin-and-soluble-urokinase-type-plasminogen-activator-receptor-for-sepsis
#3
Jing-Jing Zhao, Xiao-Li Lou, Hong-Wei Chen, Feng-Ting Zhu, Yan-Qiang Hou
The levels of decoy receptor 3 (DcR3), soluble urokinase type plasminogen activator receptor (suPAR) and procalcitonin (PCT) are significantly increased in sepsis. We investigated the diagnostic value of DcR3 combined with suPAR and PCT in sepsis. Patients with sepsis, non-infectious systemic inflammatory response comprehensive syndrome (SIRS) and healthy controls were recruited according to the diagnostic standard. We measured DcR3, suPAR, PCT, interleukin-6 (IL-6) and C-reactive protein (CRP), and the diagnostic value was evaluated by receiver operating characteristics (ROC) curves...
2018: Cellular & Molecular Biology Letters
https://www.readbyqxmd.com/read/29752756/soluble-urokinase-type-plasminogen-activator-receptor-is-associated-with-signs-of-periodontitis-in-adolescents
#4
Peter D Skottrup, Gunnar Dahlén, Vibeke Baelum, Rodrigo Lopez
Owing to its molecular stability in body fluids, soluble urokinase-type plasminogen activator receptor (suPAR) is used as a biomarker for the level of systemic inflammation. This study compares the suPAR levels in serum with those in the saliva of adolescents and evaluates their association with the periodontal conditions. Adolescents identified as screen positive (n = 87) or screen negative (n = 73) for periodontitis had saliva and serum samples taken, along with subgingival plaque samples. The concentrations of suPAR were determined in saliva and serum, and 18 microbial species and the immunoglobulin response to them was evaluated...
May 11, 2018: European Journal of Oral Sciences
https://www.readbyqxmd.com/read/29741788/cumulative-childhood-risk-is-associated-with-a-new-measure-of-chronic-inflammation-in-adulthood
#5
Line Jee Hartmann Rasmussen, Terrie E Moffitt, Jesper Eugen-Olsen, Daniel W Belsky, Andrea Danese, HonaLee Harrington, Renate M Houts, Richie Poulton, Karen Sugden, Benjamin Williams, Avshalom Caspi
BACKGROUND: Childhood risk factors are associated with elevated inflammatory biomarkers in adulthood, but it is unknown whether these risk factors are associated with increased adult levels of the chronic inflammation marker soluble urokinase plasminogen activator receptor (suPAR). We aimed to test the hypothesis that childhood exposure to risk factors for adult disease is associated with elevated suPAR in adulthood and to compare suPAR with the oft-reported inflammatory biomarker C-reactive protein (CRP)...
May 9, 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29734173/soluble-urokinase-plasminogen-activator-receptor-is-associated-with-coronary-artery-calcification-and-cardiovascular-disease-in-patients-undergoing-hemodialysis
#6
Wenjuan Wu, Yanhai Cui, Juan Hu, Ruyi Liao, Sijia Li, Liyi Mo, Lixia Xu, Yuanhan Chen, Zhiwen Lian, Xiulan Tian, Zhuo Li, Ruizhao Li, Li Zhang, Huaban Liang, Jianchao Ma, Ting Lin, Zhonglin Feng, Wei Dong, Guibao Ke, Pingjiang Ge, Zhiming Ye, Wenjiang Wang, Bing Zhang, Wei Shi, Xinling Liang, Shuangxin Liu
BACKGROUND/AIMS: Cardiovascular disease (CVD) is an important cause of morbidity and mortality in hemodialysis patients. Vascular calcification is thought to play an important role in causing CVD. Soluble urokinase plasminogen activator receptor (suPAR) is a biomarker strongly predictive of cardiovascular outcomes in the pathogenesis of diabetic patients with renal disease treated with hemodialysis. We investigated the relationship between suPAR and coronary artery calcification (CAC) in patients undergoing maintenance hemodialysis...
May 3, 2018: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/29716888/predicting-mortality-in-african-americans-with-type-2-diabetes-mellitus-soluble-urokinase-plasminogen-activator-receptor-coronary-artery-calcium-and-high-sensitivity-c-reactive-protein
#7
Salim S Hayek, Jasmin Divers, Mohamad Raad, Jianzhao Xu, Donald W Bowden, Melissa Tracy, Jochen Reiser, Barry I Freedman
BACKGROUND: Type 2 diabetes mellitus is a major risk factor for cardiovascular disease; however, outcomes in individual patients vary. Soluble urokinase plasminogen activator receptor (suPAR) is a bone marrow-derived signaling molecule associated with adverse cardiovascular and renal outcomes in many populations. We characterized the determinants of suPAR in African Americans with type 2 diabetes mellitus and assessed whether levels were useful for predicting mortality beyond clinical characteristics, coronary artery calcium (CAC), and high-sensitivity C-reactive protein (hs-CRP)...
May 1, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29667546/seminal-supar-levels-as-marker-of-abacterial-male-accessory-gland-inflammation-in-hypogonadism
#8
Domenico Milardi, Giuseppe Grande, Chiara Autilio, Francesca Mancini, Laura De Marinis, Riccardo Marana, Cecilia Zuppi, Andrea Urbani, Alfredo Pontecorvi, Silvia Baroni
Recent evidences suggest that hypogonadism is an important risk factor for lower urinary tract symptoms and benign prostatic hyperplasia. Several papers have discussed the role of chronic inflammation in the development of BPH, which may be modulated by the hypogonadal state. Soluble urokinase-type plasminogen activator receptor (suPAR), known protein marker of systemic inflammation, can be assayed in the seminal plasma and represents a reliable and sensitive marker of inflammation for the male accessory gland inflammation (MAGI)...
April 18, 2018: Protein and Peptide Letters
https://www.readbyqxmd.com/read/29657195/evaluation-of-serum-soluble-urokinase-plasminogen-activator-receptor-as-a-marker-for-steroid-responsiveness-in-children-with-primary-nephrotic-syndrome
#9
Suzan O Mousa, Salah M Saleh, Hend M Aly, Maha H Amin
Nephrotic syndrome (NS) is the most common primary glomerular disease among children. It runs a relapsing course involving prolonged periods of treatment with corticosteroids and other immunosuppressive medications. Soluble urokinase plasminogen activator receptor (suPAR) has been regarded as an inflammatory as well as a permeability factor. The aim of our study was to evaluate serum suPAR levels in children with NS and its relation to steroid responsiveness. Our study was carried out on 75 children who were already diagnosed as having NS; they were classified into three groups (steroid sensitive, steroid dependent, and steroid resistant)...
March 2018: Saudi Journal of Kidney Diseases and Transplantation
https://www.readbyqxmd.com/read/29652038/analysis-of-novel-cardiovascular-biomarkers-in-patients-with-peripheral-artery-disease-pad
#10
Peter Jirak, Moritz Mirna, Bernhard Wernly, Vera Paar, Marcus Thieme, Stefan Betge, Marcus Franz, Uta Hoppe, Alexander Lauten, Jürgen Kammler, Paul C Schulze, Michael Lichtenauer, Daniel Kretzschmar
BACKGROUND: Peripheral artery disease (PAD) is a common form of manifestation of atherosclerosis. PAD has a considerable impact on morbidity, hospitalisation rates and health- care costs. Biomarkers have been introduced in many cardiovascular disease entities over the last years. However, an analysis on the correlation of biomarker levels and PAD is still lacking. METHODS: A total of 106 patients were enrolled in this current study, 51 that were diagnosed with PAD and 55 with excluded coronary and peripheral artery disease as controls...
April 12, 2018: Minerva Medica
https://www.readbyqxmd.com/read/29602140/effect-of-simvastatin-and-ezetimibe-on-supar-levels-and-outcomes
#11
Gethin W Hodges, Casper N Bang, Julie L Forman, Michael H Olsen, Kurt Boman, Simon Ray, Y Antero Kesäniemi, Jesper Eugen-Olsen, Anders M Greve, Jørgen L Jeppesen, Kristian Wachtell
BACKGROUND AND AIMS: Soluble urokinase plasminogen activator receptor (suPAR) is an inflammatory marker associated with cardiovascular disease. Statins lower both low-density lipoprotein (LDL)-cholesterol and C-reactive protein (CRP), resulting in improved outcomes. However, whether lipid-lowering therapy also lowers suPAR levels is unknown. METHODS: We investigated whether treatment with Simvastatin 40 mg and Ezetimibe 10 mg lowered plasma suPAR levels in 1838 patients with mild-moderate, asymptomatic aortic stenosis, included in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study, using a pattern mixture model...
March 16, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29569681/can-serum-soluble-urokinase-plasminogen-activator-receptor-be-an-effective-marker-in-the-diagnosis-of-appendicitis-and-differentiation-of-complicated-cases
#12
Melih Akın, Başak Erginel, Nihat Sever, Kerem Özel, Banu Bayraktar, Abdullah Yıldız, Çetin Ali Karadağ, Meltem Tokel, Ali İhsan Dokucu
BACKGROUND: Soluble urokinase plasminogen activator receptor (suPAR) is a new biomarker of inflammation level. The aim of the study was to evaluate whether suPAR levels could be useful to detect acute appendicitis and to differentiate uncomplicated appendicitis (UA) from complicated appendicitis (CA). METHODS: We prospectively studied 105 patients consisting of 40 UA cases, 40 CA cases, and 25 control patients. Blood samples were collected to measure suPAR level, C-reactive protein level, leukocyte counts, neutrophil counts, and neutrophil percentages preoperatively...
March 2018: Ulusal Travma Ve Acil Cerrahi Dergisi, Turkish Journal of Trauma & Emergency Surgery: TJTES
https://www.readbyqxmd.com/read/29538541/soluble-urokinase-type-plasminogen-activator-receptor-as-a-measure-of-treatment-response-in-acute-exacerbation-of-copd
#13
Gehan Hassan AboEl-Magd, Maaly Mohamed Mabrouk
OBJECTIVE: To evaluate the value of soluble urokinase-type plasminogen activator receptor (suPAR) in the diagnosis of acute exacerbation of COPD (AECOPD) and in monitoring treatment response, analyzing the relationship between suPAR and fibrinogen in AECOPD. AECOPD leads to increased airway inflammation, contributing to an exaggerated release of inflammatory mediators. METHODS: We recruited 45 patients with AECOPD and 20 healthy control subjects. Medical histories were taken, and all subjects underwent clinical examination, chest X-ray, pulmonary function tests, and blood gas analysis...
January 2018: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://www.readbyqxmd.com/read/29402404/prognostic-value-of-supar-and-hs-crp-on-cardiovascular-disease
#14
Marie Zöga Diederichsen, Søren Zöga Diederichsen, Hans Mickley, Flemming Hald Steffensen, Jess Lambrechtsen, Niels Peter Rønnow Sand, Kent Lodberg Christensen, Michael Hecht Olsen, Axel Diederichsen, Mette Hjortdal Grønhøj
BACKGROUND AND AIMS: Studies have shown that soluble urokinase Plasminogen Activator Receptor (suPAR) and CRP (both inflammatory markers) and coronary artery calcification (CAC) are independent risk predictors for cardiovascular (CV) disease. The aim of this study is to assess whether suPAR and CRP have an increased predictive prognostic value beyond the traditional CV risk factors and the CAC score. METHODS: A population sample of 1179 subjects, free of CV disease was included...
April 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29391054/supar-is-associated-with-risk-of-future-acute-surgery-and-post-operative-mortality-in-acutely-admitted-medical-patients
#15
Jeppe Meyer, Morten Alstrup, Line J H Rasmussen, Martin Schultz, Steen Ladelund, Thomas H Haupt, Jens Tingleff, Kasper Iversen, Jesper Eugen-Olsen
BACKGROUND: Acutely admitted medical patients are often fragile and in risk of future surgery. The biomarker soluble urokinase plasminogen activator receptor (suPAR) is a predictor of readmission and mortality in the acute care setting. We aimed to investigate if suPAR also predicts acute surgery, which is associated with higher mortality than elective surgery, and if it predicts post-operative mortality. METHODS: A retrospective registry-based cohort study of 17,312 patients admitted to an acute medical unit in Denmark, from 18 November 2013 until 30 September 2015...
February 1, 2018: Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
https://www.readbyqxmd.com/read/29387432/supar-predicts-postoperative-complications-and-mortality-in-patients-with-asymptomatic-aortic-stenosis
#16
Gethin W Hodges, Casper N Bang, Jesper Eugen-Olsen, Michael H Olsen, Kurt Boman, Simon Ray, Antero Y Kesäniemi, Jørgen L Jeppesen, Kristian Wachtell
Background: We evaluated whether early measurement of soluble urokinase plasminogen activator receptor (suPAR) could predict future risk of postoperative complications in initially asymptomatic patients with mild-moderate aortic stenosis (AS) undergoing aortic valve replacement (AVR) surgery. Methods: Baseline plasma suPAR levels were available in 411 patients who underwent AVR surgery during follow-up in the Simvastatin and Ezetimibe in Aortic Stenosis (SEAS) study...
2018: Open Heart
https://www.readbyqxmd.com/read/29368632/serum-supar-and-syndecan-4-levels-predict-severity-of-community-acquired-pneumonia-a-prospective-multi-centre-study
#17
Qiongzhen Luo, Pu Ning, Yali Zheng, Ying Shang, Bing Zhou, Zhancheng Gao
BACKGROUND: Community-acquired pneumonia (CAP) is a major cause of death worldwide and occurs with variable severity. There are few studies focused on the expression of soluble urokinase-type plasminogen activator receptor (suPAR) and syndecan-4 in patients with CAP. METHODS: A prospective, multi-centre study was conducted between January 2014 and December 2016. A total of 103 patients with severe CAP (SCAP), 149 patients with non-SCAP, and 30 healthy individuals were enrolled...
January 24, 2018: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/29313168/clinical-and-prognostic-usefulness-of-soluble-urokinase-plasminogen-activator-receptor-in-hemodialysis-patients
#18
Rafał Nikodem Wlazeł, Iwona Szadkowska, Piotr Bartnicki, Kinga Rośniak-Bąk, Jacek Rysz
PURPOSE: Considering its prognostic usefulness and the relationship with chronic kidney disease, we analyzed the clinical utility of soluble urokinase plasminogen activator receptor (suPAR) in end-stage renal disease patients undergoing hemodialysis treatment. We focused on the association between suPAR levels and clinical outcomes, especially those related to cardiovascular events and mortality as well as the effect of hemodialysis on the protein levels. METHODS: We enrolled 64 patients...
February 2018: International Urology and Nephrology
https://www.readbyqxmd.com/read/29289378/prognostic-power-of-biomarkers-for-short-term-mortality-in-the-elderly-patients-seen-in-emergency-departments-due-to-infections
#19
Agustín Julián-Jiménez, María Cecilia Yañez, Juan González-Del Castillo, Manuel Salido-Mota, Begoña Mora-Ordoñez, María Jesús Arranz-Nieto, Manuel R Chanovas-Borras, Ferrán Llopis-Roca, Josep María Mòdol-Deltell, Gema Muñoz
OBJECTIVES: To analyse and compare 30-day mortality prognostic power of several biomarkers (C-reactive protein, procalcitonin, lactate, suPAR and pro-adremomedullin) in elderly patients seen in Emergency Departments (ED) due to infections. Secondly, if these could improve the prognostic accuracy of sepsis criteria (systemic inflammatory response syndrome and quick Sepsis-related Organ Failure Assessment [qSOFA]). METHODS: A prospective, observational, multicentre and analytical study...
December 27, 2017: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/29251000/presepsin-a-potential-biomarker-of-pji-a-comparative-analysis-with-known-and-new-infection-biomarkers
#20
Monica Gioia Marazzi, Filippo Randelli, Marco Brioschi, Lorenzo Drago, Carlo Luca Romanò, Giuseppe Banfi, Luca Massaccesi, Calogero Crapanzano, Franca Morelli, Massimiliano Marco Corsi Romanelli, Emanuela Galliera
There is still no "gold standard" for the diagnosis and prognosis of post-operative periprosthetic joint infection (PJI). Among serum biomarkers, an emerging molecule is presepsin, the soluble fraction of CD14, recently described in other settings as a powerful diagnostic tool to detect sepsis at different degrees of severity. The aim of this study was to investigate the diagnostic and prognostic value of presepsin in PJI. A total of 30 patients with PJI and 30 patients without PJI were enrolled. Presepsin, C-reactive protein (CRP), serum interleukin (IL)-6, triggering receptor expressed on myeloid cells 1 (TREM-1), CCL2, matrix metalloproteinase 9 (MMP-9), CD163, osteopontin (OPN), and toll-like receptor 2 (TLR2) were measured at different times after surgery...
January 2018: International Journal of Immunopathology and Pharmacology
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