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Circulating Progenitor Cells

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https://www.readbyqxmd.com/read/29147957/mobilization-of-endothelial-progenitor-cell-in-patients-with-acute-ischemic-stroke
#1
Yushuang Deng, Jian Wang, Guiqiong He, Fei Qu, Min Zheng
Endothelial progenitor cells (EPCs) have important effect in tissue repair in ischemic organs. The present study was conducted to demonstrate the mobilization of EPCs and its possible mechanism after acute ischemic stroke (AIS). A total of 148 individuals were examined, including 106 patients with ischemic stroke and 42 healthy controls. Seventy-one patients with imaging-confirmed AIS were examined at days 1, 7, 14, and 21 after stroke onset. Circulating EPCs were quantified by flow cytometry using CD133 and KDR surface markers...
November 16, 2017: Neurological Sciences
https://www.readbyqxmd.com/read/29138752/the-effect-of-granulocyte-colony-stimulating-factor-on-the-progression-of-atherosclerosis-in-animal-models-a-meta-analysis
#2
REVIEW
Manli Liu, Kejian Liu, Dongdong Chen, Hongzhi Chen, Kunming Sun, Xinxin Ju, Jiaojiao Lan, Yang Zhou, Weishan Wang, Lijuan Pang
Background: Atherosclerosis is a common inflammatory disease. Stem cell and endothelial progenitor cell treatments can improve cardiac function after myocardial infarction. Granulocyte colony-stimulating factor (G-CSF) is a mobilisation agent, mobilising stem cells from the bone marrow to circulation in the blood. G-CSF may constitute a treatment of atherosclerosis. We have conducted meta-analysis to evaluate the current evidence for the effect of G-CSF on the progression of atherosclerosis in animal models and to provide reference for preclinical experiments and future human clinical trials of atherosclerosis treatment...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29133210/high-speed-flow-cytometry-allows-the-detection-of-circulating-endothelial-cells-in-hemangioblastoma-patients
#3
Sara De Biasi, Lara Gibellini, Alberto Feletti, Giacomo Pavesi, Elena Bianchini, Domenico Lo Tartaro, Simone Pecorini, Anna De Gaetano, Rosalberta Pullano, Milena Nasi, Marcello Pinti, Andrea Cossarizza
Circulating endothelial cells (CECs) detach from the intima monolayer after endothelial damages. Their circulating endothelial progenitors (CEPs) represent less than 0.01% of nucleated blood cells. Increased levels of CECs and CEPs have been detected in patients with several types of cancer, suggesting that they could be a useful blood-based marker for detecting a tumor, or for monitoring its clinical course. However, their routine monitoring is time consuming and technically challenging. Here, we present a flow cytometry method for quantifying such cells in a cohort of patients with hemangioblastoma (HB)...
November 10, 2017: Methods: a Companion to Methods in Enzymology
https://www.readbyqxmd.com/read/29130939/open-the-gates-vascular-neurocrine-signaling-mobilizes-hematopoietic-stem-and-progenitor-cells
#4
Tomer Itkin, Jésus María Gómez-Salinero, Shahin Rafii
Mobilization of hematopoietic stem and progenitor cells (HSPCs) from the bone marrow (BM) into the peripheral blood is a complex process that is enhanced dramatically under stress-induced conditions. A better understanding of how the mobilization process is regulated will likely facilitate the development of improved clinical protocols for stem cell harvesting and transplantation. In this issue of the JCI, Singh et al. (1) showed that the truncated cleaved form of neurotransmitter neuropeptide Y (NPY) actively promotes a breach of BM vascular sinusoidal portals, thereby augmenting HSPC trafficking to the circulation...
November 13, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29123530/human-cardiac-derived-stem-progenitor-cells-fine-tune-monocyte-derived-descendants-activities-toward-cardiac-repair
#5
Noémie Dam, Hocine Rachid Hocine, Itziar Palacios, Olga DelaRosa, Ramón Menta, Dominique Charron, Armand Bensussan, Hicham El Costa, Nabila Jabrane-Ferrat, Wilfried Dalemans, Eleuterio Lombardo, Reem Al-Daccak
Cardiac repair following MI relies on a finely regulated immune response involving sequential recruitment of monocytes to the injured tissue. Monocyte-derived cells are also critical for tissue homeostasis and healing process. Our previous findings demonstrated the interaction of T and natural killer cells with allogeneic human cardiac-derived stem/progenitor cells (hCPC) and suggested their beneficial effect in the context of cardiac repair. Therefore, we investigated here whether monocytes and their descendants could be also modulated by allogeneic hCPC toward a repair/anti-inflammatory phenotype...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29117787/reprogramming-of-adult-peripheral-blood-cells-into-human-induced-pluripotent-stem-cells-as-a-safe-and-accessible-source-of-endothelial-cells
#6
Pavel Simara, Lenka Tesarova, Daniela Rehakova, Simon Farkas, Barbara Salingova, Katerina Kutalkova, Eva Vavreckova, Pavel Matula, Petr Matula, Lenka Veverkova, Irena Koutna
New approaches in regenerative medicine and vasculogenesis have generated a demand for sufficient numbers of human endothelial cells (ECs). ECs and their progenitors (EPCs) reside on the interior surface of blood and lymphatic vessels or circulate in peripheral blood; however, their numbers are limited and they are difficult to expand after isolation. Recent advances in human induced pluripotent stem cell (hiPSC) research have opened possible avenues to generate unlimited numbers of ECs from easily accessible cell sources, such as the peripheral blood...
November 8, 2017: Stem Cells and Development
https://www.readbyqxmd.com/read/29114919/circulating-progenitor-cells-in-patients-with-familial-hypercholesterolemia
#7
P B Sandesara, V Ramjee, N Ghasemzadeh, Y Guo, N Bhatia, Q Li, L Vaughn, C Nell-Dybdahl, E K Waller, E A Mahar, K Brigham, P W F Wilson, A Quyyumi, N-A Le, L S Sperling
OBJECTIVE: Familial hypercholesterolemia (FH) is a genetic disease with very high levels of circulating low density lipoprotein cholesterol (LDL-C) levels that leads to accelerated atherosclerosis. Lipoprotein apheresis is an effective treatment option for patients with FH and results in reduced cardiovascular morbidity and mortality. Circulating progenitor cells (CPCs) are markers of overall vascular health and diminished levels have been associated with decreased reparative potential and worse outcomes...
November 8, 2017: Journal of Clinical Apheresis
https://www.readbyqxmd.com/read/29109697/circulating-endothelial-progenitor-cells-in-type-1-diabetic-patients-relation-with-patients-age-and-disease-duration
#8
Adolfo Arcangeli, Elena Lastraioli, Barbara Piccini, Massimo D'Amico, Lorenzo Lenzi, Serena Pillozzi, Maria Calabrese, Sonia Toni, Annarosa Arcangeli
Objectives: Circulating endothelial progenitor cells (cEPCs) have been reported to be dysfunctional in diabetes mellitus (DM) patients, accounting for the vascular damage and the ensuing high risk for cardiovascular disease (CVD) characteristic of this disease. The aim of the present study was to evaluate the number of circulating cEPCs in type 1 DM (T1DM) patients, without clinical vascular damage, of different ages and with different disease duration. Methods: An observational, clinical-based prospective study was performed on T1DM patients enrolled in two clinical centers...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29104943/the-fountain-of-youth-a-tale-of-parabiosis-stem-cells-and-rejuvenation
#9
Massimo Conese, Annalucia Carbone, Elisa Beccia, Antonella Angiolillo
Transfusion (or drinking) of blood or of its components has been thought as a rejuvenation method since ancient times. Parabiosis, the procedure of joining two animals so that they share each others blood circulation, has revitalized the concept of blood as a putative drug. Since 2005, a number of papers have reported the anti-ageing effect of heterochronic parabiosis, which is joining an aged mouse to a young partner. The hallmark of aging is the decline of regenerative properties in most tissues, partially attributed to impaired function of stem and progenitor cells...
2017: Open Medicine (Warsaw, Poland)
https://www.readbyqxmd.com/read/29103037/circulating-progenitor-cells-correlate-with-memory-posterior-cortical-thickness-and-hippocampal-perfusion
#10
Daniel A Nation, Alick Tan, Shubir Dutt, Elissa C McIntosh, Belinda Yew, Jean K Ho, Anna E Blanken, Jung Yun Jang, Kathleen E Rodgers, Aimée Gaubert
BACKGROUND: Bone marrow-derived progenitor cells survey the vasculature and home to sites of tissue injury where they can promote repair and regeneration. It has been hypothesized that these cells may play a protective role neurodegenerative and vascular cognitive impairment. OBJECTIVE: To evaluate progenitor cell levels in older adults with and without mild cognitive impairment (MCI), and to relate circulating levels to memory, brain volume, white matter lesion volume, and cerebral perfusion...
November 1, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29101610/endothelial-microparticles-are-associated-to-pathogenesis-of-idiopathic-pulmonary-fibrosis
#11
Nour C Bacha, Adeline Blandinieres, Elisa Rossi, Nicolas Gendron, Nathalie Nevo, Séverine Lecourt, Coralie L Guerin, Jean Marie Renard, Pascale Gaussem, Eduardo Angles-Cano, Chantal M Boulanger, Dominique Israel-Biet, David M Smadja
Idiopathic pulmonary fibrosis (IPF) is a devastating disease characterized by obliteration of alveolar architecture, resulting in declining lung function and ultimately death. Pathogenic mechanisms remain unclear but involve a concomitant accumulation of scar tissue together with myofibroblasts activation. Microparticles (MPs) have been investigated in several human lung diseases as possible pathogenic elements, prognosis markers and therapeutic targets. We postulated that levels and cellular origins of circulating MPs might serve as biomarkers in IPF patients and/or as active players of fibrogenesis...
November 3, 2017: Stem Cell Reviews
https://www.readbyqxmd.com/read/29096827/pleiotropic-effects-of-regular-lipoprotein-apheresis
#12
Helmut Sinzinger, Sabine Steiner, Kurt Derfler
BACKGROUND: Lipoprotein(LP)-apheresis is the treatment of choice in patients suffering from severe familial hypercholesterolemia. A wide range of mechanisms has been claimed to be responsible for the known clinical benefit. METHODS: Patients suffering from heterozygous familial hypercholesterolemia undergoing LP-apheresis either with direct adsorption of lipoproteins (DALI) or dextran sulfate (DS) were examined. A total volume of 10 l blood was exchanged. Non-lipid effects, mainly concerning endothelial function (circulating endothelial cells, circulating endothelial progenitor cells, flow-mediated vasodilation, microalbuminuria) as well as left ventricular ejection fraction and homocysteine were assessed...
November 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/29094480/myocardial-infarction-does-not-affect-circulating-hematopoietic-stem-and-progenitor-cell-self-renewal-ability-in-a-rat-model
#13
J M Kröpfl, C M Spengler, A Frobert, G Ajalbert, M N Giraud
Due to the importance of peripheral blood hematopoietic stem and progenitor cells (HPCs) in post-acute regeneration after acute myocardial infarction (MI), the present study aimed to investigate count and secondary replating capacity/self-renewal ability of HPCs in peripheral blood before and two weeks after MI. In nine female Lewis inbred rats (n = 9), myocardial infarction was induced by ligation of the left coronary artery while another nine had surgery without ligation for control purposes. Myocardial infarction was confirmed by troponin I concentrations 24 h after MI...
November 2, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29089925/advances-in-understanding-of-structural-reorganization-in-the-hypothalamic-neurosecretory-system
#14
REVIEW
Seiji Miyata
The hypothalamic neurosecretory system synthesizes neuropeptides in hypothalamic nuclei and releases them from axonal terminals into the circulation in the neurohypophysis (NH) and median eminence (ME). This system plays a crucial role in regulating body fluid homeostasis and social behaviors as well as reproduction, growth, metabolism, and stress responses, and activity-dependent structural reorganization has been reported. Current knowledge on dynamic structural reorganization in the NH and ME, in which the axonal terminals of neurosecretory neurons directly contact the basement membrane (BM) of a fenestrated vasculature, is discussed herein...
2017: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29080864/endothelial-progenitor-cell-biology-and-vascular-recovery-following-transradial-cardiac-catheterization
#15
Andrew Mitchell, Takeshi Fujisawa, Nicholas L Mills, Mairi Brittan, David E Newby, Nicholas L M Cruden
BACKGROUND: Transradial catheterization is associated with radial artery injury and vasomotor dysfunction and represents an accessible model of acute vascular injury in humans. We characterized vascular injury and functional recovery to understand the role of circulating endothelial progenitor cells in vascular repair. METHODS AND RESULTS: In 50 patients (aged 64±10 years, 70% male) undergoing transradial cardiac catheterization, radial artery injury was assessed by optical coherence tomography and examination of explanted vascular sheaths...
October 28, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29080294/microparticles-carrying-peroxisome-proliferator-activated-receptor-alpha-restore-the-reduced-differentiation-and-functionality-of-bone-marrow-derived-cells-induced-by-high-fat-diet
#16
Luisa Vergori, Emilie Lauret, Raffaella Soleti, Ramaroson Andriantsitohaina, M Carmen Martinez
Metabolic pathologies such as diabetes and obesity are associated with decreased level of circulating and bone marrow (BM)-derived endothelial progenitor cells (EPCs). It is known that activation of peroxisome proliferator-activated receptor alpha (PPARα) may stimulate cell differentiation. In addition, microparticles (MPs), small membrane vesicles produced by activated and apoptotic cells, are able to reprogram EPCs. Here, we evaluated the role of MPs carrying PPARα on both phenotype and function of progenitor cells from mice fed with a high-fat diet (HFD)...
October 28, 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/29078283/humanized-mouse-model-supports-development-function-and-tissue-residency-of-human-natural-killer-cells
#17
Dietmar Herndler-Brandstetter, Liang Shan, Yi Yao, Carmen Stecher, Valerie Plajer, Melanie Lietzenmayer, Till Strowig, Marcel R de Zoete, Noah W Palm, Jie Chen, Catherine A Blish, Davor Frleta, Cagan Gurer, Lynn E Macdonald, Andrew J Murphy, George D Yancopoulos, Ruth R Montgomery, Richard A Flavell
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (IL15) and human signal regulatory protein alpha (SIRPA) knock-in mouse on a Rag2(-/-)Il2rg(-/-) background (SRG-15)...
October 25, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29069365/monocyte-and-haematopoietic-progenitor-reprogramming-as-common-mechanism-underlying-chronic-inflammatory-and-cardiovascular-diseases
#18
Renate M Hoogeveen, Matthias Nahrendorf, Niels P Riksen, Mihai G Netea, Menno P J de Winther, Esther Lutgens, Boerge Nordestgaard, Michel Neidhart, Erik S G Stroes, Alberico L Catapano, Siroon Bekkering
A large number of cardiovascular events are not prevented by current therapeutic regimens. In search for additional, innovative strategies, immune cells have been recognized as key players contributing to atherosclerotic plaque progression and destabilization. Particularly the role of innate immune cells is of major interest, following the recent paradigm shift that innate immunity, long considered to be incapable of learning, does exhibit immunological memory mediated via epigenetic reprogramming. Compelling evidence shows that atherosclerotic risk factors promote immune cell migration by pre-activation of circulating innate immune cells...
October 24, 2017: European Heart Journal
https://www.readbyqxmd.com/read/29057227/getting-old-through-the-blood-circulating-molecules-in-aging-and-senescence-of-cardiovascular-regenerative-cells
#19
REVIEW
Francesco Angelini, Francesca Pagano, Antonella Bordin, Vittorio Picchio, Elena De Falco, Isotta Chimenti
Global aging is a hallmark of our century. The natural multifactorial process resulting in aging involves structural and functional changes, affecting molecules, cells, and tissues. As the western population is getting older, we are witnessing an increase in the burden of cardiovascular events, some of which are known to be directly linked to cellular senescence and dysfunction. In this review, we will focus on the description of a few circulating molecules, which have been correlated to life span, aging, and cardiovascular homeostasis...
2017: Frontiers in Cardiovascular Medicine
https://www.readbyqxmd.com/read/29036193/gestational-age-related-patterns-of-amot-methylation-are-revealed-in-preterm-infant-endothelial-progenitors
#20
Giovanna Vinci, Christophe Buffat, Stéphanie Simoncini, Farid Boubred, Isabelle Ligi, Florent Dumont, Bernard Le Bonniec, Thierry Fournier, Daniel Vaiman, Françoise Dignat-George, Umberto Simeoni
OBJECTIVE: Preterm birth is associated with altered angiogenesis and with increased risk of cardiovascular dysfunction and hypertension at adulthood. We previously demonstrated that in preterm newborns circulating cord blood endothelial progenitor cells (ECFC), responsible for angio/vasculogenesis, are reduced in number and display altered angiogenic properties. Altered angiogenic function was associated with a decreased expression of pro-angiogenic genes, among which the AMOT gene which is a strong positive regulator of angiogenesis...
2017: PloS One
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