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Circulating Progenitor Cells

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https://www.readbyqxmd.com/read/28218626/building-discontinuous-liver-sinusoidal-vessels
#1
Courtney T Griffin, Siqi Gao
Blood vessels have a unified mission to circulate blood throughout the body; however, they have additional diverse and specialized roles in various organs. For example, in the liver, discontinuous sinusoids, which are fenestrated capillaries with intercellular gaps and a fragmented basement membrane, facilitate delivery of macromolecules to highly metabolic hepatocytes. During embryonic development, discontinuous sinusoids also allow circulating hematopoietic progenitor and stem cells to populate the liver and promote blood cell differentiation...
February 20, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28218468/igf-1-receptor-expression-on-circulating-osteoblast-progenitor-cells-predicts-tissue-based-bone-formation-rate-and-response-to-teriparatide-in-premenopausal-women-with-idiopathic-osteoporosis
#2
Adi Cohen, Stavroula Kousteni, Brygida Bisikirska, Jayesh G Shah, J Sanil Manavalan, Robert R Recker, Joan Lappe, David W Dempster, Hua Zhou, Donald J McMahon, Mariana Bucovsky, Mafo Kamanda-Kosseh, Julie Stubby, Elizabeth Shane
We have previously reported that premenopausal women with idiopathic osteoporosis (IOP) have profound microarchitectural deficiencies and heterogeneous bone remodeling. Those with the lowest bone formation rate have higher baseline serum IGF-1 levels and less robust response to teriparatide. Because IGF-1 stimulates bone formation and is critical for teriparatide action on osteoblasts, these findings suggest a state of IGF-1 resistance in some IOP women. To further investigate the hypothesis that osteoblast and IGF-1 related mechanisms mediate differential responsiveness to teriparatide in IOP, we studied circulating osteoblast progenitor (COP) cells and their IGF-1 receptor (IGF-1R) expression...
February 20, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28210260/from-the-cradle-to-the-grave-the-role-of-macrophages-in-erythropoiesis-and-erythrophagocytosis
#3
REVIEW
Thomas R L Klei, Sanne M Meinderts, Timo K van den Berg, Robin van Bruggen
Erythropoiesis is a highly regulated process where sequential events ensure the proper differentiation of hematopoietic stem cells into, ultimately, red blood cells (RBCs). Macrophages in the bone marrow play an important role in hematopoiesis by providing signals that induce differentiation and proliferation of the earliest committed erythroid progenitors. Subsequent differentiation toward the erythroblast stage is accompanied by the formation of so-called erythroblastic islands where a central macrophage provides further cues to induce erythroblast differentiation, expansion, and hemoglobinization...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28209719/adaptive-nk-cells-can-persist-in-patients-with-gata2-mutation-depleted-of-stem-and-progenitor-cells
#4
Heinrich Schlums, Moonjung Jung, Hongya Han, Jakob Theorell, Venetia Bigley, Samuel C C Chiang, David S J Allan, Jan K Davidson-Moncada, Rachel E Dickinson, Tim D Holmes, Amy P Hsu, Danielle Townsley, Thomas Winkler, Weixin Wang, Pål Aukrust, Ingvild Nordøy, Katherine R Calvo, Steve M Holland, Matthew Collin, Cynthia E Dunbar, Yenan T Bryceson
Heterozygous GATA2 mutation is associated with immunodeficiency, lymphedema, and myelodysplastic syndrome. Disease presentation is variable, often coinciding with loss of circulating dendritic cells, monocytes, B cells, and NK cells. Nonetheless, in a proportion of patients carrying GATA2 mutation, NK cells persist. We found that peripheral blood NK cells in symptomatic patients uniformly lacked expression of the transcription factor PLZF, as well as expression of intracellular signaling proteins FcϵRγ, SYK, and EAT-2 in a variegated manner...
February 16, 2017: Blood
https://www.readbyqxmd.com/read/28203485/relationship-of-circulating-cxcr4-epc-with-prognosis-of-mild-traumatic-brain-injury-patients
#5
Yunpeng Lin, Lan Lan Luo, Jian Sun, Weiwei Gao, Ye Tian, Eugene Park, Andrew Baker, Jieli Chen, Rongcai Jiang, Jianning Zhang
To investigate the changes of circulating endothelial progenitor cells (EPCs) and stromal cell-derived factor-1α (SDF-1α)/CXCR4 expression in patients with mild traumatic brain injury (TBI) and the correlation between EPC level and the prognosis of mild TBI. 72 TBI patients (57 mild TBI, 15 moderate TBI patients) and 25 healthy subjects (control) were included. The number of circulating EPCs, CD34(+), and CD133(+) cells and the percentage of CXCR4(+) cells in each cell population at 1,4,7,14,21 days after TBI were counted by flow cytometer...
February 2017: Aging and Disease
https://www.readbyqxmd.com/read/28189115/n-3-polyunsaturated-fatty-acids-alleviate-high-glucose-mediated-dysfunction-of-endothelial-progenitor-cells-and-prevent-ischemic-injuries-both-in-vitro-and-in-vivo
#6
Shao-Chih Chiu, Che-Yi Chao, En-Pei Isabel Chiang, Jia-Ning Syu, Raymond L Rodriguez, Feng-Yao Tang
Hyperglycemia is associated with a reduced number of endothelial progenitor cells (EPCs) that impairs vascular function. Circulating EPCs play important roles in postnatal neovasculogenesis and the prevention of ischemic injury. Frequent consumption of fish oil (FO) that is abundant with eicosapentaenoic acid (EPA)/docosahexaenoic acid (DHA) is reportedly associated with an alleviation of diabetic complications and a lowered incidence of cardiovascular disease. The aim of this study was to examine whether N-3 polyunsaturated fatty acids such as EPA and DHA would reverse the high glucose-mediated dysfunction of EPCs in vitro and thereby prevent the ischemic injury that occurs under the hyperglycemic conditions in Type 2 diabetes (T2D) db(-/-) mice...
January 28, 2017: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/28183821/exercise-induced-upregulation-of-endothelial-adhesion-molecules-in-human-skeletal-muscle-and-number-of-circulating-cells-with-remodeling-properties
#7
Anna Strömberg, Eric Rullman, Eva Jansson, Thomas Gustafsson
Multipotent cells have received great interest due to their potential capacity to repair and remodel peripheral tissues. We examined the effect of an acute exercise bout on the number of circulating cells with known remodeling properties, and the level of factors in plasma and skeletal muscle tissue with potential to recruit these cells. Twenty healthy male subjects performed a 60 min cycling exercise. Blood samples for flow cytometry were drawn from 10 subjects (Group 1) before and up to 2 h after exercise, and absolute cell counts of the classical (CD14(++)CD16(-)), intermediate (CD14(++)CD16(+)), and nonclassical (CD14(+)CD16(++)) monocyte (MO) subpopulations, and of CD45(dim)CD34(+)VEGFR2(+) endothelial progenitor cells (EPCs) were measured using bead-based determination...
February 9, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/28182332/challenging-the-great-vascular-wall-can-we-envision-a-simple-yet-comprehensive-therapy-for-stroke
#8
Marta Machado-Pereira, Tiago Santos, Lino Ferreira, Liliana Bernardino, Raquel Ferreira
Stroke is a leading cause of death in adult life, closely behind ischemic heart disease, and causes a significant and abiding socioeconomic burden. However, current therapies are not able to ensure full neurologic and/or sequelae-free recovery to all stroke survivors. We believe treatment efficacy and patient rehabilitation could be enhanced significantly by targeting blood-brain barrier (BBB) deregulation and inflammation-induced barrier loss occurring after stroke. In this pathological context, bone marrow-derived endothelial progenitor cells (EPC) enter the bloodstream towards the lesion site but their insufficient numbers and impaired angiogenic ability compromise neurovascular regeneration...
February 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28177697/dysfunction-of-endothelial-progenitor-cells-in-hyperlipidemic-rats-involves-the-increase-of-nadph-oxidase-derived-reactive-oxygen-species-production
#9
Ting-Bo Li, Jie-Jie Zhang, Bin Liu, Xiu-Ju Luo, Qi-Lin Ma, Jun Peng
NADPH oxidase (NOX) is a major source of reactive oxygen species (ROS) in the body and it plays a key role in mediation of oxidative injury in cardiovascular system. The purposes of this study are to evaluate the status of NOX in EPCs of hyperlipidemic rats and to determine whether NOX- derived ROS promotes the dysfunction of endothelial progenitor cells (EPCs). The rats were fed on high-fat diet for 8 weeks to establish a hyperlipidemic rat model, which showed the increased plasma lipids and the impaired functions of circulating EPCs (including the reduced abilities in migration and adhesion), accompanied by an increase in NOX activity and ROS production...
October 20, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28170188/endothelial-progenitor-cells-as-prognostic-markers-of-preterm-birth-associated-complications
#10
Mariane Bertagnolli, Anne Monique Nuyt, Bernard Thébaud, Thuy Mai Luu
Preterm birth is associated with alteration of the vascular tree that can result in disease states such as bronchopulmonary dysplasia and retinopathy of prematurity during the neonatal period and emphysema and hypertension in adulthood. Studies have suggested a potential role for endothelial progenitor cells in the pathophysiology of prematurity-related complications involving blood vessels; however, this knowledge has never been synthesized. We conducted a systematic review of the published data to examine the characteristics of endothelial progenitor cells in relation to preterm birth in humans...
January 2017: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/28164674/endothelial-progenitor-cells-epc-count-by-multicolor-flow-cytometry-in-healthy-individuals-and-diabetes-mellitus-dm-patients
#11
Mesude Falay, Server Aktas
BACKGROUND: The present study aimed to determine circulating Endothelial Progenitor Cell (EPC) counts by multicolor flow cytometry in healthy individuals and diabetic subjects by means of forming an analysis procedure using a combination of monoclonal antibodies (moAbs), which would correctly detect the circulating EPC count. METHODS: The circulating EPC count was detected in 40 healthy individuals (20 Female, 20 Male; age range: 26 - 50 years) and 30 Diabetes Mellitus (DM) patients (15 Female, 15 Male; age range: 42 - 55) by multicolor flow cytometry (FCM) in a single-tube panel consisting of 5 CD45/CD31/CD34/CD309/ SYTO® and 16 monoclonal antibodies...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28164672/circulating-endothelial-progenitor-cells-were-increased-in-patients-with-thin-cap-fibroatheroma
#12
Qiang Tan, Qingsheng Wang, Shuangyue Zhang, Ximing Qi, Yang Li
BACKGROUND: We used virtual histology-intravascular ultrasound (VH-IVUS) to evaluate the relationship between circulating endothelial progenitor cells (EPC) and thin-cap fibroatheroma (TCFA). METHODS: This study included 52 patients with unstable angina who underwent coronary angiography and IVUS examination. Patients were divided into a TCFA group (n = 21) or a non-TCFA group (n = 31) based on VH-IVUS performance. Before angiography, peripheral blood levels of EPC were measured by flow cytometry...
November 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28163189/future-of-circulating-tumor-cells-in-the-melanoma-clinical-and-research-laboratory-settings
#13
Luisa M De Souza, Bailey M Robertson, Gavin P Robertson
Circulating tumor cells (CTC) have become a field of interest for oncologists based on the premise that they constitute the underpinning for metastatic dissemination. The lethal nature of cancer is no longer attributed to solid tumor formation, but rather to the process of metastasis; shifting the focus of current studies towards the isolation and identification of metastatic progenitors, such as CTCs. CTCs originate from primary tumor masses that undergo morphologic and genetic alterations, which involve the release of mesenchymal-like cancer cells into the bloodstream, capable of invading nearby tissues for secondary tumor development...
February 2, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28161590/granulocyte-macrophage-colony-stimulating-factor-dependent-cd11c-positive-cells-differentiate-into-active-osteoclasts
#14
Nina Ruef, Silvia Dolder, Daniel Aeberli, Michal Seitz, Deepak Balani, Willy Hofstetter
Levels of circulating cytokines are elevated in inflammatory diseases. Previously, it was shown that interleukin (IL-)17A, in synergism with 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] and tumor necrosis factor α (TNFα), induces the release of granulocyte-macrophage colony-stimulating factor (GM-CSF) by murine osteoblasts in vitro. In this study, we further analyzed the effects of GM-CSF on osteoclast development in vitro. The effects of IL-17A, TNFα, and 1,25(OH)2D3 on the regulation of osteoclast development were investigated in cocultures of bone marrow-derived osteoclast progenitor cells (OPC) and mouse calvarial osteoblasts...
February 1, 2017: Bone
https://www.readbyqxmd.com/read/28148896/investigated-the-safety-of-intra-renal-arterial-transfusion-of-autologous-cd34-cells-and-time-courses-of-creatinine-levels-endothelial-dysfunction-biomarkers-and-micro-rnas-in-chronic-kidney-disease-patients-phase-i-clinical-trial
#15
Mel S Lee, Fan-Yen Lee, Yung-Lung Chen, Pei-Hsun Sung, Hsin-Ju Chiang, Kuan-Hung Chen, Tien-Hung Huang, Yi-Ling Chen, John Y Chiang, Tsung-Cheng Yin, Hsueh-Wen Chang, Hon-Kan Yip
This was a phase I clinical trial to investigate the safety of autologous peripheral-blood-derived CD34+ cell therapy for patients with chronic kidney disease (CKD-treatment) (i.e., at Stages III and IV). Between November 2014 and October 2015, a total of 10 study patients were prospectively enrolled into this phase I trial. Patients who failed to enroll into the trial in the initial state of eligibility assessment were served as CKD-control group (n = 9). The health-control group was composed of 10 volunteers for the purposes of comparing (1) circulation level of endothelial progenitor cells (EPCs), (2) angiogenesis ability, and (3) anti-apoptotic miRNAs between healthy subjects and CKD patients...
January 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28128678/permanent-atrial-fibrillation-impairs-the-function-of-circulating-endothelial-progenitor-cells
#16
Qiang Tan, Shuangyue Zhang, Ximing Qi, Xiaoyi Zou, Qiang Sun
OBJECTIVE: to determine whether functions of endothelial progenitor cells (EPCs) were impaired in patients with permanent atrial fibrillation (AF). METHODS: 35 patients with permanent AF (AF group) and 35 age and sex matched controls (control group) were collected. The numbers of circulating CD34(+)/KDR(+) cells were determined with flow cytometry in the two groups. Cell proliferation, tube formation, nitric oxygen (NO) and vascular endothelial growth factor (VEGF) were assayed...
January 27, 2017: Postgraduate Medicine
https://www.readbyqxmd.com/read/28123523/different-but-synergistic-effects-of-bone-marrow-derived-vegfr2-and-vegfr2-cd45-cells-during-hepatocellular-carcinoma-progression
#17
Xiaolin Zhu, Hongyuan Zhou, Jingtao Luo, Yunlong Cui, Huikai Li, Wei Zhang, Feng Fang, Qiang Li, Ti Zhang
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-associated mortality worldwide in men. Bone marrow-derived cells (BMDCs), including circulating endothelial progenitor cells, have been reported to be involved in the progression of HCC. The complexity of BMDCs inspires further interest in the study of HCC. In the present study, highly metastatic HCC models with BM function deficiency/reconstruction were established by sublethal irradiation/BM transplantation. The effects of vascular endothelial growth factor receptor-2 (VEGFR2)(+) or VEGFR2(-)/cluster of differentiation 45 (CD45)(+) BMDCs on HCC growth were evaluated...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28121873/the-effect-of-atorvastatin-on-the-viability-of-ischemic-skin-flaps-in-diabetic-rats
#18
Ya-Chao Jia, Jia Xu, Hong-Hao Chen, Qing-Lin Kang, Yi-Min Chai
BACKGROUND: Endothelial progenitor cells play a critical role in neovascularization. However, the mobilization, recruitment, and functional capacity of endothelial progenitor cells are significantly impaired in diabetes. Statins have been shown to augment the number and improve the function of endothelial progenitor cells. This study investigated the effects of statins on the viability of ischemic skin flaps in diabetic rats. METHODS: Twenty normal and 40 diabetic Sprague-Dawley rats were included in this study...
February 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28118945/ro52-autoantibodies-arise-from-self-reactive-progenitors-in-a-mother-of-a-child-with-neonatal-lupus
#19
Joanne H Reed, Miroslaw K Gorny, Liuzhe Li, Timothy Cardozo, Jill P Buyon, Robert M Clancy
The detection of cardiac conduction defects in an 18-24 week old foetus in the absence of structural abnormalities predicts with near certainty the presence of autoantibodies against 60kD and 52kD SSA/Ro in the mother regardless of her health status. Previous studies have emphasized these autoantibodies as key mediators of tissue injury. The aim of this study was to focus on the anti-Ro52 response to determine whether these autoantibodies originate from progenitors that are inherently self-reactive or from B-cells that acquire self-reactivity during an immune response...
January 21, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28115811/deficiency-of-endothelial-progenitor-cells-associates-with-graft-thrombosis-in-patients-undergoing-endovascular-therapy-of-dysfunctional-dialysis-grafts
#20
Tsung-Yan Chen, Lin Lin, Mu-Yang Hsieh, Jui-Cheng Kuo, Chia-Ling Wang, Ren-Huei Wang, Chao-Lun Lai, Po-Hsun Huang, Chih-Cheng Wu
BACKGROUND: The deficiency of endothelial progenitor cells has been demonstrated to be associated with cardiovascular events in patients undergoing dialysis. However, their correlation with dialysis graft outcomes remains unknown. The objective of this study was to investigate the relationship between circulating endothelial progenitor cells and dialysis graft outcomes. METHODS: After excluding 14 patients with acute coronary syndrome, decompensated heart failure or graft thrombosis in the prior three months, a total of 120 patients undergoing dialysis who underwent endovascular therapy of dysfunctional dialysis grafts were prospectively enrolled...
January 2017: Acta Cardiologica Sinica
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