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Circulating Progenitor Cells

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https://www.readbyqxmd.com/read/29782940/defining-osteoblast-and-adipocyte-lineages-in-the-bone-marrow
#1
J L Pierce, D L Begun, J J Westendorf, M E McGee-Lawrence
Bone is a complex endocrine organ that facilitates structural support, protection to vital organs, sites for hematopoiesis, and calcium homeostasis. The bone marrow microenvironment is a heterogeneous niche consisting of multipotent musculoskeletal and hematopoietic progenitors and their derivative terminal cell types. Amongst these progenitors, bone marrow mesenchymal stem/stromal cells (BMSCs) may differentiate into osteogenic, adipogenic, myogenic, and chondrogenic lineages to support musculoskeletal development as well as tissue homeostasis, regeneration and repair during adulthood...
May 18, 2018: Bone
https://www.readbyqxmd.com/read/29781855/improving-senescent-wound-healing-with-local-and-systemic-therapies
#2
Caroline Szpalski, Parag Butala, Meredith T Vandegrift, Denis Knobel, Robert J Allen, Pierre B Saadeh, Stephen M Warren
The population is aging, and the prevalence of chronic wounds is increasing. Because neovascularization is essential for tissue repair and both local and systemic factors affect new blood vessel formation, we hypothesize that altering either pathway would reciprocally enhance wound healing in the aged. To test this hypothesis, p53 was locally suppressed and endothelial progenitor cells (EPCs) were systemically mobilized in a murine model of senescent wound healing.Bilateral 6-mm full-thickness stented wounds were made on the dorsum of Zmpste24 mice...
May 17, 2018: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29760742/correlation-between-therapeutic-efficacy-of-cd34-cell-treatment-and-directed-in-vivo-angiogenesis-in-patients-with-end-stage-diffuse-coronary-artery-disease
#3
Tien-Hung Huang, Cheuk-Kwan Sun, Yi-Ling Chen, Pei-Hsun Sung, Chi-Hsiang Chu, Mel S Lee, Yuan-Ping Lin, Hon-Kan Yip, Fan-Yen Lee
Background: This study was aimed at testing the association between the therapeutic efficacy of CD34+ cell treatment in patients with end-stage diffuse coronary artery disease as reflected in angiographic grading and results of directed in vivo angiogenesis assay (DIVAA) on their isolated peripheral blood mononuclear cell- (PBMC-) derived endothelial progenitor cells (EPCs). Methods: Angiographic grades (0: <5%; 1: 5-35%; 2: 35-75%; 3: >75%) which presented the improvement of vessel density pre- and post-CD34+ treatment were given to 30 patients with end-stage diffuse coronary artery disease having received CD34+ cell treatment...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760722/microrna-126-priming-enhances-functions-of-endothelial-progenitor-cells-under-physiological-and-hypoxic-conditions-and-their-therapeutic-efficacy-in-cerebral-ischemic-damage
#4
Qunwen Pan, Jieyi Zheng, Donghui Du, Xiaorong Liao, Chunlian Ma, Yi Yang, Yanyu Chen, Wangtao Zhong, Xiaotang Ma
Endothelial progenitor cells (EPCs) have shown the potential for treating ischemic stroke (IS), while microRNA-126 (miR-126) is reported to have beneficial effects on endothelial function and angiogenesis. In this study, we investigated the effects of miR-126 overexpression on EPCs and explore the efficacy of miR-126-primed EPCs (EPCmiR-126 ) in treating IS. The effects of miR-126 overexpression on EPC proliferation, migratory, tube formation capacity, reactive oxygen species (ROS) production, and nitric oxide (NO) generation were determined...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760721/decreased-count-and-dysfunction-of-circulating-epcs-in-postmenopausal-hypercholesterolemic-females-via-reducing-no-production
#5
Ying Luo, Quan-Neng Yan, Wan-Zhou Wu, Fan-Yan Luo
Endothelial progenitor cells (EPCs) contribute to the endogenous endothelial repair program during hypercholesterolemia. EPC count and migratory and proliferative capacities remain unchanged in the premenopausal female with hypercholesterolemia. However, the changes of count and activity of circulating EPCs in the hypercholesterolemic postmenopausal females are unknown. Here, we find that the migratory and proliferative capacities of circulating EPCs were decreased in patients with hypercholesterolemia versus normocholesterolemia...
2018: Stem Cells International
https://www.readbyqxmd.com/read/29760458/hyperglycemia-does-not-affect-tissue-repair-responses-in-shear-stress-induced-atherosclerotic-plaques-in-apoe-mice
#6
Sabrina Hsiung, Anki Knutsson, Jenifer Vallejo, Pontus Dunér, Suvi E Heinonen, Ann-Cathrine Jönsson-Rylander, Eva Bengtsson, Jan Nilsson, Anna Hultgårdh-Nilsson
The mechanisms responsible for macrovascular complications in diabetes remain to be fully understood. Recent studies have identified impaired vascular repair as a possible cause of plaque vulnerability in diabetes. This notion is supported by observations of a reduced content of fibrous proteins and smooth muscle cell mitogens in carotid endarterectomy from diabetic patients along with findings of decreased circulating levels of endothelial progenitor cells. In the present study we used a diabetic mouse model to characterize how hyperglycemia affects arterial repair responses...
May 14, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29752312/slit2-modulates-the-inflammatory-phenotype-of-orbit-infiltrating-fibrocytes-in-graves-disease
#7
Roshini Fernando, Ana Beatriz Diniz Grisolia, Yan Lu, Stephen Atkins, Terry J Smith
Human CD34+ fibrocytes, circulating monocyte lineage progenitor cells, have recently been implicated in thyroid-associated ophthalmopathy (TAO), the ocular manifestation of Graves' disease (GD). Fibrocytes express constitutive MHC class II (MHC-2) and, surprisingly, thyroglobulin (Tg) and functional thyrotropin (TSH) receptor (TSHR). Underlying expression of these thyroid proteins is the autoimmune regulator protein (AIRE). Fibrocytes respond robustly to TSH and thyroid-stimulating Igs by generating extremely high levels of inflammatory cytokines, such as IL-6...
May 11, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29750826/conditional-deletion-of-sost-in-msc-derived-lineages-identifies-specific-cell-type-contributions-to-bone-mass-and-b-cell-development
#8
Cristal S Yee, Jennifer O Manilay, Jiun C Chang, Nicholas R Hum, Deepa K Murugesh, Jamila Bajwa, Melanie E Mendez, Aris E Economides, Daniel J Horan, Alexander G Robling, Gabriela G Loots
Sclerostin (Sost) is a negative regulator of bone formation and blocking its function via antibodies has shown great therapeutic promise by increasing both bone mass in humans and animal models. Sclerostin deletion in Sost knockout mice (Sost-/- ) causes high bone mass (HBM) similar to Sclerosteosis patients. Sost-/- mice have been shown to display an up to 300% increase in bone volume/total volume (BV/TV), relative to aged matched controls, and it has been postulated that the main source of skeletal Sclerostin is the osteocyte...
May 11, 2018: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/29741564/replacement-of-dietary-saturated-fat-with-unsaturated-fats-increases-numbers-of-circulating-endothelial-progenitor-cells-and-decreases-numbers-of-microparticles-findings-from-the-randomized-controlled-dietary-intervention-and-vascular-function-divas-study
#9
Michelle Weech, Hana Altowaijri, Jordi Mayneris-Perxachs, Katerina Vafeiadou, Jacqueline Madden, Susan Todd, Kim G Jackson, Julie A Lovegrove, Parveen Yaqoob
Background: Endothelial progenitor cells (EPCs) and microparticles are emerging as novel markers of cardiovascular disease (CVD) risk, which could potentially be modified by dietary fat. We have previously shown that replacing dietary saturated fatty acids (SFAs) with monounsaturated or n-6 (ω-6) polyunsaturated fatty acids (MUFAs or PUFAs, respectively) improved lipid biomarkers, blood pressure, and markers of endothelial activation, but their effects on circulating EPCs and microparticles are unclear...
May 8, 2018: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/29739800/loss-of-the-liver-x-receptors-disrupts-the-balance-of-hematopoietic-populations-with-detrimental-effects-on-endothelial-progenitor-cells
#10
Adil Rasheed, Ricky Tsai, Carolyn L Cummins
BACKGROUND: The liver X receptors (LXRs; α/β) are nuclear receptors known to regulate cholesterol homeostasis and the production of select hematopoietic populations. The objective of this study was to determine the importance of LXRs and a high-fat high-cholesterol diet on global hematopoiesis, with special emphasis on endothelial progenitor cells (EPCs), a vasoreparative cell type that is derived from bone marrow hematopoietic stem cells. METHODS AND RESULTS: Wild-type and LXR double-knockout ( Lxr αβ -/- ) mice were fed a Western diet (WD) to increase plasma cholesterol levels...
May 8, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29739448/associations-between-endothelial-progenitor-cells-clinical-characteristics-and-coronary-restenosis-in-patients-undergoing-percutaneous-coronary-artery-intervention
#11
Fernando S Montenegro, Marcelo Correia, Fabiana Muccillo, Christina G Souza E Silva, Andrea De Lorenzo
OBJECTIVE: Endothelial progenitor cells (EPCs) are produced in the bone marrow and mobilized to the peripheral blood playing a key role in endothelial repair. The objective of this study was to evaluate circulating EPC before and after percutaneous coronary intervention (PCI) with stent implantation and their associations with coronary restenosis and adverse cardiovascular events. Venous blood was obtained before and the day after PCI. Quantification of total white blood count and identification of EPCs (CD45- CD34+ CD31+ CD133/2+ CD309+ ) through immunophenotyping by flow cytometry was performed...
May 8, 2018: BMC Research Notes
https://www.readbyqxmd.com/read/29737539/increased-circulation-mobilization-of-endothelial-progenitor-cells-in-preterm-infants-with-retinopathy-of-prematurity
#12
Homa Babaei, Mahdi Alibabrdel, Simin Asadian, Vahid Siavashi, Masoome Jabarpour, Seyed Mahdi Nassiri
Retinopathy of prematurity (ROP) is a result of increased pathological neoangiogenesis of the retina in preterm infants. Cells responsible for the pathogenesis of ROP are unclear, but some evidence indicates that bone marrow derived cells are involved in this disorder. Endothelial progenitor cells (EPCs), play a role in angiogenesis in response to tissue ischemia or endothelial damage. In this study, the number of cEPCs in preterm infants with ROP was determined to identify whether the circulation mobilization of EPCs is associated with ROP...
May 8, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29732993/endothelial-progenitor-cells-as-molecular-targets-in-vascular-senescence-and-repair
#13
Divya Rana, Saurabh Sharma
Endothelial progenitor cells are circulating blood cells derived from various sources like bone marrow, spleen, umbilical cord, liver, kidney and other sources that play a vital role in the regeneration of endothelial lining of blood vessels and wound repair. There are two types of EPCs, early EPCs and late EPCs. EPCs are believed to originate from hematopoietic stem cells and mesenchymal stem cells. The mobilization of progenitor cells from bone marrow to the peripheral circulation is highly regulated under both normal physiological conditions and stress...
May 1, 2018: Current Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29728748/prolonged-hematopoietic-and-myeloid-cellular-response-in-patients-after-an-acute-coronary-syndrome-measured-with-18-f-dpa-714-pet-ct
#14
Simone L Verweij, Lotte C A Stiekema, Ronak Delewi, Kang H Zheng, Sophie J Bernelot Moens, Jeffrey Kroon, Charlotte I Stroes, Miranda Versloot, Jan J Piek, Hein J Verberne, Erik S G Stroes
PURPOSE: An acute coronary syndrome (ACS) is characterized by a multi-level inflammatory response, comprising activation of bone marrow and spleen accompanied by augmented release of leukocytes into the circulation. The duration of this response after an ACS remains unclear. Here, we assessed the effect of an ACS on the multi-level inflammatory response in patients both acutely and after 3 months. METHODS: We performed 18 F-DPA-714 PET/CT acutely and 3 months post-ACS in eight patients and eight matched healthy controls...
May 4, 2018: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29720573/parabiosis-and-single-cell-rna-sequencing-reveal-a-limited-contribution-of-monocytes-to-myofibroblasts-in-kidney-fibrosis
#15
Rafael Kramann, Flavia Machado, Haojia Wu, Tetsuro Kusaba, Konrad Hoeft, Rebekka K Schneider, Benjamin D Humphreys
Fibrosis is the common final pathway of virtually all chronic injury to the kidney. While it is well accepted that myofibroblasts are the scar-producing cells in the kidney, their cellular origin is still hotly debated. The relative contribution of proximal tubular epithelium and circulating cells, including mesenchymal stem cells, macrophages, and fibrocytes, to the myofibroblast pool remains highly controversial. Using inducible genetic fate tracing of proximal tubular epithelium, we confirm that the proximal tubule does not contribute to the myofibroblast pool...
May 3, 2018: JCI Insight
https://www.readbyqxmd.com/read/29707151/high-levels-of-circulating-endothelial-progenitor-cells-in-patients-with-diabetic-retinopathy-are-positively-associated-with-arhgap22-expression
#16
Yu-Chuen Huang, Wen-Ling Liao, Jane-Ming Lin, Ching-Chu Chen, Shih-Ping Liu, Shih-Yin Chen, Yu-Ning Lin, Yu-Jie Lei, Huan-Ting Liu, Yu-Jen Chen, Fuu-Jen Tsai
Diabetic retinopathy (DR) is a common microvascular complication of diabetes. Circulating endothelial progenitor cells (EPCs) are derived from bone marrow and are characterized by pathological retinal neovascularization. Rho GTPase Activating Protein 22 ( ARHGAP22 ) is a DR susceptibility gene that interacts with its downstream regulatory protein ras-related C3 botulinum toxin substrate 1 (Rac1), to assist in endothelial cell angiogenesis and increasing capillary permeability. The aim of this study was to elucidate the relationship between ARHGAP22 expression and EPC levels in type 2 diabetes (T2D) patients with DR...
April 3, 2018: Oncotarget
https://www.readbyqxmd.com/read/29703959/a-cryptic-cycle-in-haematopoietic-niches-promotes-initiation-of-malaria-transmission-and-evasion-of-chemotherapy
#17
Rebecca S Lee, Andrew P Waters, James M Brewer
Blood stage human malaria parasites may exploit erythropoietic tissue niches and colonise erythroid progenitors; however, the precise influence of the erythropoietic environment on fundamental parasite biology remains unknown. Here we use quantitative approaches to enumerate Plasmodium infected erythropoietic precursor cells using an in vivo rodent model of Plasmodium berghei. We show that parasitised early reticulocytes (ER) in the major sites of haematopoiesis establish a cryptic asexual cycle. Moreover, this cycle is characterised by early preferential commitment to gametocytogenesis, which occurs in sufficient numbers to generate almost all of the initial population of circulating, mature gametocytes...
April 27, 2018: Nature Communications
https://www.readbyqxmd.com/read/29700294/reduction-of-endoplasmic-reticulum-stress-improves-angiogenic-progenitor-cell-function-in-a-mouse-model-of-type-1-diabetes
#18
Maulasri Bhatta, Krishna Chatpar, Zihua Hu, Joshua J Wang, Sarah X Zhang
Persistent vascular injury and degeneration in diabetes are attributed in part to defective reparatory function of angiogenic cells. Our recent work implicates endoplasmic reticulum (ER) stress in high-glucose-induced bone marrow (BM) progenitor dysfunction. Herein, we investigated the in vivo role of ER stress in angiogenic abnormalities of streptozotocin-induced diabetic mice. Our data demonstrate that ER stress markers and inflammatory gene expression in BM mononuclear cells and hematopoietic progenitor cells increase dynamically with disease progression...
April 27, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29696821/a-simple-antegrade-perfusion-method-for-isolating-viable-single-cardiomyocytes-from-neonatal-to-aged-mice
#19
Mariko Omatsu-Kanbe, Kengo Yoshioka, Ryo Fukunaga, Hironori Sagawa, Hiroshi Matsuura
The aim of this study was to establish a simple and reproducible antegrade perfusion method for isolating single viable mouse heart cells and to determine the standard practical protocols that are appropriate for mice of various ages. Antegrade perfusion was performed by injecting perfusate from near the apex of the left ventricle of the excised heart, the aorta of which was clamped, using an infusion pump. This could thoroughly perfuse the myocardium through the coronary circulation. All procedures were carried out on a prewarmed heater mat under a microscope, which allows for the processes of injection and perfusion to be monitored...
May 2018: Physiological Reports
https://www.readbyqxmd.com/read/29693558/s1p%C3%A2-regulates-passive-systemic-anaphylaxis-in-mice-but-is-dispensable-for-canonical-ige-mediated-responses-in-mast-cells
#20
Joseph M Kulinski, Richard L Proia, Elisabeth M Larson, Dean D Metcalfe, Ana Olivera
Mast cells are key players in the development of inflammatory allergic reactions. Cross-linking of the high-affinity receptor for IgE (Fc&epsilon;RI) on mast cells leads to the generation and secretion of the sphingolipid mediator, sphingosine-1-phosphate (S1P) which is able, in turn, to transactivate its receptors on mast cells. Previous reports have identified the expression of two of the five receptors for S1P on mast cells, S1P₁ and S1P₂, with functions in Fc&epsilon;RI-mediated chemotaxis and degranulation, respectively...
April 25, 2018: International Journal of Molecular Sciences
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