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https://www.readbyqxmd.com/read/28944970/comparison-of-a-polymeric-pseudostationary-phase-in-ekc-with-ods-stationary-phase-in-rp-hplc
#1
Xinjiong Ni, Min Zhang, Xiaoping Xing, Yuhua Cao, Guangqun Cao
Poly(stearyl methacrylate-co-methacrylic acid) (P(SMA-co-MAA)) was induced as pseudostationary phase (PSP) in electrokinetic chromatography (EKC). The n-octadecyl groups in SMA were the same as that in octadecylsilane (ODS) C18 column. Thus, the present work focused on the comparison of selectivity between polymeric PSP and ODS stationary phase (SP), and the effect of organic modifiers on the selectivity of polymeric PSP and ODS SP. 1-butanol could directly interacted with PSP as a Class I modifier, and improved both of the methylene selectivity and polar group selectivity...
September 25, 2017: Electrophoresis
https://www.readbyqxmd.com/read/28942314/effects-of-long-term-grassland-management-on-the-carbon-and-nitrogen-pools-of-different-soil-aggregate-fractions
#2
Gary Egan, Michael J Crawley, Dario A Fornara
Common grassland management practices include animal grazing and the repeated addition of lime and nutrient fertilizers to soils. These practices can greatly influence the size and distribution of different soil aggregate fractions, thus altering the cycling and storage of carbon (C) and nitrogen (N) in grassland soils. So far, very few studies have simultaneously addressed the potential long-term effect that multiple management practices might have on soil physical aggregation. Here we specifically ask whether and how grazing, liming and nutrient fertilization might influence C and N content (%) as well as C and N pools of different soil aggregate fractions in a long-term grassland experiment established in 1991 at Silwood Park, Berkshire, UK...
September 20, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28942050/lentivirus-mediated-over-expression-of-let-7b-microrna-suppresses-hepatic-fibrosis-in-the-mouse-infected-with-schistosoma-japonicum
#3
Na Tang, Yuan Wu, Weiliang Cao, Yu Liang, Yongqiang Gao, Li Hu, Qinglan Yang, Yuqiu Zhou, Faqing Tang, Jianhua Xiao
Transforming growth factor-β (TGF-β) signaling pathway is documented to participate in liver fibrosis via multifactorial mechanisms. microRNA Let-7b (Let-7b) has been proved to alleviate cell fibrosis through regulating TGF-β receptor I (TβRI), but whether it is involved in Schistosomiasis liver fibrosis (SLF) has not been determined. In the present, SLF mice model was used to investigate Let-7b's function and mechanism in SLF. We found that hepatic let-7b expression was continuously declined in SLF, accompanied by the induction of TGF-β pathway molecules (TGF-β1, TβRI), profibrogenic mediators (α-SMA, colla I), and Th1/Th2 cells response factors (IFN-γ, IL-4)...
September 20, 2017: Experimental Parasitology
https://www.readbyqxmd.com/read/28942023/mirna-23-regulates-high-glucose-induced-epithelial-to-mesenchymal-transition-in-human-mesotheial-peritoneal-cells-by-targeting-vdr
#4
Lina Yang, Yi Fan, Xiuli Zhang, Jianfei Ma
Epithelial-mesenchymal transition(EMT) is the main reason for peritoneal fibrosis and the mechanism underlying peritoneal EMT were extensively studied in recent years. Recent researches showed that miRNAs were so important in the development of organ EMT and fibrosis, the role of microRNAs on peritoneal dialysis have also been studied. In the current study, we investigated microRNA-23(miR-23) expression in high glucose(HG) induced EMT in human mesotheial peritoneal cells(HPMCs). We found that HG promoted EMT, which was characterized by the upregulation of mesenchymal markers α-SMA and FN and downregulation of epithelial marker E-cadherin...
September 20, 2017: Experimental Cell Research
https://www.readbyqxmd.com/read/28941022/endoglin-in-human-liver-disease-and-murine-models-of-liver-fibrosis-a-protective-factor-against-liver-fibrosis
#5
Muhammad Alsamman, Viktor Sterzer, Steffen Klaus Meurer, Hacer Sahin, Ute Schäper, Deniz Kuscuoglu, Pavel Strnad, Ralf Weiskirchen, Christian Trautwein, David Scholten
BACKGROUND & AIMS: Liver fibrosis is the outcome of chronic liver injury. TGF-β is a major profibrogenic cytokine modulating hepatic stellate cell (HSC) activation and extracellular matrix homeostasis. This study analyzes the effect of Endoglin (Eng), a TGF-β type III auxiliary receptor, on fibrogenesis in two models of liver injury by HSC specific endoglin deletion. METHODS: Eng expression was measured in human and murine samples of liver injury. After generating (GFAPC)(re(+)) Eng(Δ)(HSC) mice the impact of Endoglin deletion on chronic liver fibrosis was analyzed...
September 20, 2017: Liver International: Official Journal of the International Association for the Study of the Liver
https://www.readbyqxmd.com/read/28940685/the-antifibrotic-effects-of-pentoxifylline-improve-the-efficacy-of-gemcitabine-in-human-pancreatic-tumor-xenografts
#6
Jung Ho Kim, Byung Cheol Shin, Won Sang Park, Jaehwi Lee, Hyo-Jeong Kuh
We investigated the combinatorial effects of pentoxifylline (PTX) on the efficacy of gemcitabine (GEM) in a human pancreatic tumor xenograft model. PTX significantly improved the efficacy of GEM, as shown by a 50% reduction in tumor growth rate at 4 weeks of treatment compared with that in animals given GEM alone. The fluorescent drug doxorubicin (DOX) was used to test whether drug delivery was improved by PTX, contributing to the improved efficacy of GEM. PTX given for 2 weeks prior to DOX administration improved drug distribution by 1...
September 23, 2017: Cancer Science
https://www.readbyqxmd.com/read/28936800/evodiamine-ameliorates-liver-fibrosis-in-rats-via-tgf-%C3%AE-1-smad-signaling-pathway
#7
Dongmei Yang, Li Li, Shanjun Qian, Lixin Liu
Liver fibrosis is considered to be a result of chronic liver pathological changes, and hepatic stellate cells (HSCs) play an important role during this process. Evodiamine, an indole alkaloid derived from Evodia rutaecarpa, exhibits pharmacological activities. This study focused on the effects of evodiamine on carbon tetrachloride (CCl4)-induced liver fibrosis in rats and HSCs in vitro via the TGF-β1/Smad signaling pathway. A liver fibrosis rat model was established by the intraperitoneal injection of CCl4 (3 ml/kg, 30% in olive oil)...
September 21, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28935682/role-of-eosinophils-in-the-initiation-and-progression-of-pancreatitis-pathogenesis
#8
Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Anil Mishra
Eosinophilic pancreatitis (EP) is reported in human; however, the etiology and the role of eosinophils in EP pathogenesis is a poorly understood and not excusably explored. Therefore, it is interesting to examine the role of eosinophils in the initiation and progression of pancreatitis pathogenesis. Therefore, we performed real time PCR, ELISA, western blot, anti-MBP immunostaining, Chloroesterase and Massons' trichrome analysis were performed to examine transcript and protein levels of eosinophil active cytokines, chemokines, eosinophils, mast cells and collagen tissue accumulation...
September 21, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28935639/isolation-and-characterization-of-endothelial-to-mesenchymal-transition-cells-in-pulmonary-arterial-hypertension
#9
Toshio Suzuki, Erica J Carrier, Megha A Talati, Anandharajan Rathinasabapathy, Xinping Chen, Rintaro Nishimura, Yuji Tada, Koichiro Tatsumi, James D West
Endothelial-to-mesenchymal transition (EndMT) is a process in which endothelial cells lose polarity and cell-to-cell contacts, and undergo a dramatic remodeling of the cytoskeleton. It has been implicated in initiation and progression of pulmonary arterial hypertension (PAH). However, the characteristics of cells which have undergone EndMT-cells in vivo have not been reported and so remain unclear. To study this, sugen5416 and hypoxia (SuHx)-induced PAH was established in Cdh5-Cre / Gt(ROSA)26Sor(tm4(ACTB-tdTomato,-EGFP)Luo)/J double-transgenic mice, in which GFP was stably expressed in pan-endothelial cells...
September 21, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28932030/immunohistochemical-analysis-of-stromal-fibrocytes-and-myofibroblasts-to-envision-the-invasion-and-lymph-node-metastasis-in-oral-squamous-cell-carcinoma
#10
Sowmya J Rao, Jyothi Bellur Madhava Rao, Pp Jagadish Rao
BACKGROUND: Tumor cells work in close coordination with stromal elements from its stage of emergence to metastasis. The study was designed to assess the presence and distribution pattern of stromal fibrocytes and myofibroblasts in oral squamous cell carcinoma (OSCC). Possibility of using these stromal cells as a marker for invasion and lymphnode metastasis was evaluated. MATERIALS AND METHODS: A total of 40 cases of OSCC consisting twenty cases of each lymph node positive (pN+) and lymph node negative (pN0) samples and ten normal oral mucosa (NOM) tissues were subjected to double immunostaining using CD34 and alpha-smooth muscle actin (α-SMA) antibodies...
May 2017: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/28931214/baicalin-alleviates-radiation-induced-epithelial-mesenchymal-transition-of-primary-type-ii-alveolar-epithelial-cells-via-tgf-%C3%AE-and-erk-gsk3%C3%AE-signaling-pathways
#11
Jinhua Lu, Yazhen Zhong, Zechen Lin, Xianlei Lin, Zhaohui Chen, Xuping Wu, Nan Wang, Haiqiao Zhang, Siyu Huang, Yuan Zhu, Yuanyuan Wang, Shengyou Lin
BACKGROUND: Radiation therapy is commonly used to treat thoracic malignancies. However, it may lead to severe lung pneumonitis and ultimately fibrosis. Irradiation has been reported to increase epithelial-mesenchymal transition (EMT) of type II alveolar epithelial cells (AEC), which play an important role in pulmonary fibrosis. The transforming growth factor-β (TGF-β) and ERK/glycogen synthase kinase 3β (GSK3β) pathways are critically involved in radiation-induced EMT. In the present study, we investigated whether baicalin was a novel therapeutic candidate for radiation-induced EMT in type II AEC...
September 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28930257/physicochemical-properties-antioxidant-and-cytotoxic-activities-of-crude-extracts-and-fractions-from-phyllanthus-amarus
#12
Van Tang Nguyen, Jennette A Sakoff, Christopher J Scarlett
Background:Phyllanthus amarus (P. amarus) has been used as a medicinal plant for the prevention and treatment of chronic ailments such as diabetes, hepatitis, and cancer. Methods: The physicochemical properties, antioxidant and cytotoxic activities of crude extracts and fractions from P. amarus were determined using spectrophotometric method. Results: The P. amarus methanol (PAM) extract had lower levels of residual moisture (7.40%) and water activity (0.24) and higher contents of saponins, phenolics, flavonoids, and proanthocyanidins (1657...
June 18, 2017: Medicines (Basel, Switzerland)
https://www.readbyqxmd.com/read/28929571/repetitive-transcranial-magnetic-stimulation-over-inferior-frontal-cortex-impairs-the-suppression-but-not-expression-of-action-impulses-during-action-conflict
#13
A Dilene van Campen, Richard Kunert, Wery P M van den Wildenberg, K Richard Ridderinkhof
In the recent literature, the effects of noninvasive neurostimulation on cognitive functioning appear to lack consistency and replicability. We propose that such effects may be concealed unless dedicated, sensitive, and process-specific dependent measures are used. The expression and subsequent suppression of response capture are often studied using conflict tasks. Response-time distribution analyses have been argued to provide specific measures of the susceptibility to make fast impulsive response errors, as well as the proficiency of the selective suppression of these impulses...
September 20, 2017: Psychophysiology
https://www.readbyqxmd.com/read/28929107/microrna-195-activates-hepatic-stellate-cells-in-vitro-by-targeting-smad7
#14
Li-Ying Song, Yu-Tao Ma, Cui-Fang Wu, Chun-Jiang Wang, Wei-Jin Fang, Shi-Kun Liu
BACKGROUND AND AIM: Aberrant activation of the TGF-β1/Smad pathway contributes to the activation of hepatic stellate cells (HSCs). MicroRNA-195 has been shown to regulate the activation of HSCs. The aim of this study was to investigate the role of miRNA-195 in HSCs activation. METHODS: A liver fibrotic rat model induced by diethylnitrosamine was established. Dual luciferase reporter assays were performed to verify that Smad7 was the target of miRNA-195. The expression levels of miR-195, Smad7, and α-SMA in HSC-T6 transfected, respectively, with miR-195 mimic, inhibitor, or control were measured by qRT-PCR...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28929094/gestational-age-dependent-increase-of-survival-motor-neuron-protein-in-umbilical-cord-derived-mesenchymal-stem-cells
#15
Sota Iwatani, Nur Imma Fatimah Harahap, Dian Kesumapramudya Nurputra, Shinya Tairaku, Akemi Shono, Daisuke Kurokawa, Keiji Yamana, Khin Kyae Mon Thwin, Makiko Yoshida, Masami Mizobuchi, Tsubasa Koda, Kazumichi Fujioka, Mariko Taniguchi-Ikeda, Hideto Yamada, Ichiro Morioka, Kazumoto Iijima, Hisahide Nishio, Noriyuki Nishimura
BACKGROUND: Spinal muscular atrophy (SMA) is the most common genetic neurological disease leading to infant death. It is caused by loss of survival motor neuron (SMN) 1 gene and subsequent reduction of SMN protein in motor neurons. Because SMN is ubiquitously expressed and functionally linked to general RNA metabolism pathway, fibroblasts (FBs) are most widely used for the assessment of SMN expression in SMA patients but usually isolated from skin biopsy samples after the onset of overt symptoms...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28928636/smn-deficiency-increases-the-intrinsic-excitability-of-motoneurons
#16
Saravanan Arumugam, Ana Garcera, Rosa M Soler, Lucía Tabares
During development, motoneurons experience significant changes in their size and in the number and strength of connections that they receive, which requires adaptive changes in their passive and active electrical properties. Even after reaching maturity, motoneurons continue to adjust their intrinsic excitability and synaptic activity for proper functioning of the sensorimotor circuit in accordance with physiological demands. Likewise, if some elements of the circuit become dysfunctional, the system tries to compensate for the alterations to maintain appropriate function...
2017: Frontiers in Cellular Neuroscience
https://www.readbyqxmd.com/read/28926913/enhanced-methanogenic-degradation-of-cellulose-containing-sewage-via-fungi-methanogens-syntrophic-association-in-an-anaerobic-membrane-bioreactor
#17
Rong Chen, Yulun Nie, Nobuyuki Tanaka, Qigui Niu, Qian Li, Yu-You Li
An anaerobic membrane bioreactor was configured for methanogenic degradation of cellulose-containing sewage. The degradation performance and microbial changes were evaluated under five hydraulic retention times (HRTs). The results indicated the methane production was largely enhanced with 92.6% efficiency of chemical oxygen demand (COD) converting to methane and 80% proportion of methane in produced biogas, meanwhile the biomass yield presented the fewest at the shortest HRT 8h. Enhanced methane production with decreased biomass yield was attributed to an association between fungi and methanogens...
September 8, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28926777/experience-as-knowledge-disability-distillation-and-reprogenetic-decision-making
#18
Felicity K Boardman
'Experiential knowledge' is increasingly recognised as an important influence on reproductive decision-making. 'Experiential knowledge of disability' in particular is a significant resource within prenatal testing/screening contexts, enabling prospective parents to imagine and appraise future lives affected by disability. However, the concept of 'experiential knowledge' has been widely critiqued for its idiosyncrasy, its impermanence and consequently its perceived inferiority to (medical) knowledge. This paper explores some of these key critiques of experiential knowledge through an analysis of its constitution and uses in the context of reproductive decision-making...
September 8, 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28926603/scavenging-of-reactive-oxygen-species-by-astaxanthin-inhibits-epithelial-mesenchymal-transition-in-high-glucose-stimulated-mesothelial-cells
#19
Kazuaki Hara, Chieko Hamada, Keiichi Wakabayashi, Reo Kanda, Kayo Kaneko, Satoshi Horikoshi, Yasuhiko Tomino, Yusuke Suzuki
BACKGROUND: High glucose concentrations influence the functional and structural development of the peritoneal membrane. We previously reported that the oral administration of astaxanthin (AST) suppressed peritoneal fibrosis (PF) as well as inhibited oxidative stress, inflammation, and epithelial-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) in a chlorhexidine-induced PF rat model. This suggests that oxidative stress induction of EMT is a key event during peritoneal damage...
2017: PloS One
https://www.readbyqxmd.com/read/28926108/bone-morphogenetic-protein-7-inhibits-endothelial-mesenchymal-transition-in-pulmonary-artery-endothelial-cell-under-hypoxia
#20
Hongyue Zhang, Ying Liu, Lixin Yan, Wei Du, Xiaodan Zhang, Min Zhang, He Chen, Yafeng Zhang, Jianqiu Zhou, Hanliang Sun, Daling Zhu
Pulmonary artery hypertension (PAH) is characterized by structural changes in pulmonary arteries. Increased numbers of cells expressing α-smooth muscle actin (α-SMA) is a nearly universal finding in the remodeled artery. It has been confirmed endothelial-to-mesenchymal transition (EndoMT) may be a source of those α-SMA-expressing cells. In addition, the EndoMT is reversible. Here, we show that under hypoxia, the expression of bone morphogenetic protein 7 (BMP-7) was decreased both in vivo and in vitro. We also found that under normoxia, BMP-7 deficiency induced spontaneous EndoMT and cell migration...
September 19, 2017: Journal of Cellular Physiology
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