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Laboratory quality

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https://www.readbyqxmd.com/read/29474641/improvements-in-the-thermal-neutron-calibration-unit-tnf2-at-lnmri-ird
#1
A Astuto, S S Fernandes, K C S Patrão, E S Fonseca, W W Pereira, R T Lopes
The standard thermal neutron flux unit, TNF2, in the Brazilian National Ionizing Radiation Metrology Laboratory was rebuilt. Fluence is still achieved by moderating of four 241Am-Be sources with 0.6 TBq each. The facility was again simulated and redesigned with graphite core and paraffin added graphite blocks surrounding it. Simulations using the MCNPX code on different geometric arrangements of moderator materials and neutron sources were performed. The resulting neutron fluence quality in terms of intensity, spectrum and cadmium ratio was evaluated...
February 21, 2018: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29474515/validated-stability-indicating-high-performance-liquid-chromatographic-determination-of-lesinurad
#2
Khalid A M Attia, Nasr M El-Abasawi, Ahmed El-Olemy, Ahmed H Abdelazim
Lesinurad is a novel selective uric acid reabsorption inhibitor which has been newly approved for the treatment of the chronic gout. The behavior of lesinurad under various stress conditions (hydrolysis, oxidation, thermal and photolysis) has been investigated as per ICH guidelines. The drug has been found to be labile to acidic hydrolysis, basic hydrolysis and oxidation but stable in neutral, thermal and photolytic conditions. A high performance liquid chromatographic method has been developed for selective determination of the studied drug in the presence of its related degradation products...
February 21, 2018: Journal of Chromatographic Science
https://www.readbyqxmd.com/read/29474387/mobile-phones-as-monitors-of-personal-exposure-to-air-pollution-is-this-the-future
#3
Mawutorli Nyarku, Mandana Mazaheri, Rohan Jayaratne, Matthew Dunbabin, Md Mahmudur Rahman, Erik Uhde, Lidia Morawska
Mobile phones have a large spectrum of applications, aiding in risk prevention and improving health and wellbeing of their owners. So far, however, they have not been used for direct assessment of personal exposure to air pollution. In this study, we comprehensively evaluated the first, and the only available, mobile phone-BROAD Life-equipped with air pollution sensors (PM2.5 and VOC), to answer the question whether this technology is a viable option in the quest of reducing the burden of disease to air pollution...
2018: PloS One
https://www.readbyqxmd.com/read/29474386/peak-oxygen-uptake-in-paralympic-sitting-sports-a-systematic-literature-review-meta-and-pooled-data-analysis
#4
Julia Kathrin Baumgart, Berit Brurok, Øyvind Sandbakk
BACKGROUND: Peak oxygen uptake (VO2peak) in Paralympic sitting sports athletes represents their maximal ability to deliver energy aerobically in an upper-body mode, with values being influenced by sex, disability-related physiological limitations, sport-specific demands, training status and how they are tested. OBJECTIVES: To identify VO2peak values in Paralympic sitting sports, examine between-sports differences and within-sports variations in VO2peak and determine the influence of sex, age, body-mass, disability and test-mode on VO2peak...
2018: PloS One
https://www.readbyqxmd.com/read/29474281/the-utility-of-preoperative-laboratory-testing-before-urogynecologic-surgery
#5
Katherine E Husk, Marcella G Willis-Gray, Alexis A Dieter, Jennifer M Wu
OBJECTIVES: National guidelines for preoperative laboratory testing are based on limited, low-quality evidence. The role of age as a risk factor for testing is unclear. We sought to compare the prevalence of abnormal preoperative laboratory results in older vs younger urogynecologic surgical patients. METHODS: In this retrospective cohort study of women undergoing urogynecologic surgery, we compared older (age, ≥65 years) with younger (age, 50-64 years) women...
March 2018: Female Pelvic Medicine & Reconstructive Surgery
https://www.readbyqxmd.com/read/29471910/impact-of-quality-improvement-in-tuberculosis-laboratories-in-low-and-lower-middle-income-countries-a-systematic-review
#6
I D Olaru, H Albert, J Zallet, U-E Werner, N Ahmed, H L Rieder, M Salfinger, K Kranzer
BACKGROUND: The effect of quality improvement measures on the performance of diagnostic tuberculosis (TB) laboratories in low- and lower-middle-income countries is not known, and is the subject of this review. METHODS: Three databases were searched for quality improvement studies presenting data on performance parameters before and after the implementation of quality improvement interventions. RESULTS: Twenty-one studies were included in this review...
March 1, 2018: International Journal of Tuberculosis and Lung Disease
https://www.readbyqxmd.com/read/29471576/-vegetarian-diets-in-children-an-assessment-from-pediatrics-and-nutrition-science
#7
Mathilde Kersting, Hermann Kalhoff, Michael Melter, Thomas Lücke
In Germany, the "Dietary Schedule for the 1st year of life" and the "Optimised Mixed Diet" for children and adolescents serve as scientifically based and generally applicable dietary concepts throughout the period of growth and development. Vegetarian diets as the lacto-ovo-vegetarian diet (exclusion of meat, fish) and the vegan diet (exclusion of all food groups of animal origin) need to be evaluated for their potential to safely meet the high and specific requirements for growth and development...
February 2018: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/29471345/establishing-quality-assured-qa-laboratory-support-for-onchocerciasis-elimination-in-africa
#8
Joseph Shott, Camilla Ducker, Thomas R Unnasch, Charles D Mackenzie
An essential component in achieving accepted successful elimination of a disease or a pathogen involves the acquisition of quality-assured (QA) data that ultimately define the absence of infection or transmission in previously endemic areas. The acquisition of these essential data, in the case of onchocerciasis elimination, requires strong laboratory support for both testing and continuing evaluation/validation of the tools used for the required diagnostic and epidemiology procedures. There is also a need for standardization of the laboratory-based and field-based assays used across the onchocerciasis-endemic countries as well as continuing technical, fiscal and logistical support for laboratory activities...
March 1, 2018: International Health
https://www.readbyqxmd.com/read/29471323/what-s-to-be-done-about-laboratory-quality-process-indicators-laboratory-stewardship-the-outcomes-problem-risk-assessment-and-economic-value-responding-to-contemporary-global-challenges
#9
Frederick A Meier, Tony C Badrick, Kenneth A Sikaris
Objectives: For 50 years, structure, process, and outcomes measures have assessed health care quality. For clinical laboratories, structural quality has generally been assessed by inspection. For assessing process, quality indicators (QIs), statistical monitors of steps in the clinical laboratory total testing, have proliferated across the globe. Connections between structural and process laboratory measures and patient outcomes, however, have rarely been demonstrated. Methods: To inform further development of clinical laboratory quality systems, we conducted a selective but worldwide review of publications on clinical laboratory quality assessment...
February 17, 2018: American Journal of Clinical Pathology
https://www.readbyqxmd.com/read/29470753/spatial-variation-source-identification-and-quality-assessment-of-surface-water-geochemical-composition-in-the-indus-river-basin-pakistan
#10
Faizan Ur Rehman Qaisar, Fan Zhang, Ramesh Raj Pant, Guanxing Wang, Sardar Khan, Chen Zeng
The Indus River Basin (IRB) with an area of 139,202 km2 is the lifeline river basin of Pakistan. An intensive study was conducted in six subcatchments of the IRB with five in the Upper Indus Basin (UIB) and one of the Lower Indus Basin (LIB; between Tarbela Dam and Panjand), i.e., the Gilgit River Basin (UIB-I), Hunza River Basin (UIB-II), UIB-III, UIB-IV and UIB-V, and LIB. A total of 84 surface water samples were collected from main stream and tributaries from June to August, 2016. The pH, electric conductivity (EC), and total dissolved solids (TDS) were measured in situ, whereas major ions (Ca2+ , Mg2+ , K+ , Na+ , Cl- , SO4 2- , and NO3 - ) and Si were analyzed in the laboratory...
February 22, 2018: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/29470485/an-innovative-hiv-testing-service-using-the-internet-anonymous-urine-delivery-testing-service-at-drugstores-in-beijing-china
#11
Xiaoxia He, Guowu Liu, Dongyan Xia, Xia Feng, Yi Lv, Huanyi Cheng, Yuehua Wang, Hongyan Lu, Yan Jiang
Innovative human immunodeficiency virus (HIV) testing services will be needed to achieve the first 90 (90% of HIV-positive persons aware of their infection status) of the 90-90-90 target in China. Here, we describe an internet-based urine delivery testing service delivered through three pilot drugstores in Beijing that send specimens to a designated laboratory for HIV. From May 2016 to January 2017, we provided 500 HIV urine-testing service packs for display at the drugstores, and a total of 430 (86.0%) urine specimens were mailed back...
2018: PloS One
https://www.readbyqxmd.com/read/29470426/surface-plasmon-resonance-and-bending-loss-based-u-shaped-plastic-optical-fiber-biosensors
#12
Ariadny da S Arcas, Fábio da S Dutra, Regina C S B Allil, Marcelo M Werneck
Escherichia coli ( E. coli ) is a large and diverse bacteria group that inhabits the intestinal tract of many mammals. Most E. coli strains are harmless, however some of them are pathogenic, meaning they can make one sick if ingested. By being in the feces of animals and humans, its presence in water and food is used as indicator of fecal contamination. The main method for this microorganism detection is the bacterial culture medium that is time-consuming and requires a laboratory with specialized personnel...
February 22, 2018: Sensors
https://www.readbyqxmd.com/read/29470164/external-quality-assessment-for-zika-virus-molecular-diagnostic-testing-brazil
#13
Carlo Fischer, Celia Pedroso, Alfredo Mendrone, Ana Maria Bispo de Filippis, Antonio Carlos Rosário Vallinoto, Bergmann Morais Ribeiro, Edison Luiz Durigon, Ernesto T A Marques, Gubio S Campos, Isabelle F T Viana, José Eduardo Levi, Luciano Cesar Scarpelli, Mauricio Lacerda Nogueira, Michele de Souza Bastos, Nathalia C Santiago Souza, Ricardo Khouri, Sanny Lira, Shirley Vasconcelos Komninakis, Cécile Baronti, Rémi N Charrel, Beate M Kümmerer, Christian Drosten, Carlos Brites, Xavier de Lamballerie, Matthias Niedrig, Eduardo Martins Netto, Jan Felix Drexler
We conducted an external quality assessment of Zika virus molecular diagnostic tests in Brazil using a new Zika virus standard. Of 15 laboratories, 73% showed limited sensitivity and specificity. Viral load estimates varied significantly. Continuous quality assurance is needed to adequately estimate risk for Zika virus-associated disease and determine patient care.
May 17, 2018: Emerging Infectious Diseases
https://www.readbyqxmd.com/read/29469206/impact-of-sacubitril-valsartan-combination-in-patients-with-chronic-heart-failure-and-sleep-apnoea-syndrome-the-entresto-sas-study-design
#14
Dany Jaffuel, Nicolas Molinari, Philippe Berdague, Atul Pathak, Michel Galinier, Marion Dupuis, Jean-Etienne Ricci, Jean-Pierre Mallet, Arnaud Bourdin, François Roubille
AIMS: Sleep-disordered breathing (SDB) is a highly prevalent co-morbidity in patients with chronic heart failure (CHF) and can play a detrimental role in the pathophysiology course of CHF. However, the best way to manage SDB in CHF remains a matter of debate. Sacubitril-valsartan has been included in the 2016 European Society of Cardiology guidelines as an alternative to angiotensin-converting enzyme inhibitors to further reduce the risk of progression of CHF, CHF hospitalization, and death in ambulatory patients...
February 22, 2018: ESC Heart Failure
https://www.readbyqxmd.com/read/29468738/combined-effects-of-environmental-factors-on-human-perception-and-objective-performance-a-review-of-experimental-laboratory-works
#15
REVIEW
S Torresin, G Pernigotto, F Cappelletti, A Gasparella
The present paper reports the outcomes of a literature survey aimed at exploring how different environmental factors - i.e. acoustic, thermal, visual and air quality stimuli - interact in affecting building occupants' perception and performance. Recent laboratory studies have been collected and their methodological approaches reviewed in terms of experimental design, adopted exposures conditions, perception and performance assessment methods. Results have been summarized and compared to identify interaction patterns between environmental factors and possible practical implications for improving the design of both experimental studies and the built environment...
February 22, 2018: Indoor Air
https://www.readbyqxmd.com/read/29468292/compact-devices-for-generation-of-reference-trace-voc-mixtures-a-new-concept-in-assuring-quality-at-chemical-and-biochemical-laboratories
#16
Alessia Demichelis, Céline Pascale, Maricarmen Lecuna, Bernhard Niederhauser, Guido Sassi, Maria Paola Sassi
Volatile organic compounds (VOCs) in gas mixtures at trace level (nmol/mol) are routinely measured by chemical and biochemical laboratories as climate indicators, indoor air quality pollutants from building materials emissions, contaminants in food and beverages, and biomarkers in body fluids (blood, urine, breath) of occupational exposure or human diseases. Current analytical instruments used for measurements are gas chromatographs equipped with various injector and detector configurations. The assurance of measurement quality is done by using a huge amount of certified liquid VOC standard solutions (or gaseous VOC standard cylinders) with multiple dilutions to reach the required trace level...
February 22, 2018: Analytical and Bioanalytical Chemistry
https://www.readbyqxmd.com/read/29467718/on-the-accurate-determination-of-shock-wave-time-pressure-profile-in-the-experimental-models-of-blast-induced-neurotrauma
#17
Maciej Skotak, Eren Alay, Namas Chandra
Measurement issues leading to the acquisition of artifact-free shock wave pressure-time profiles are discussed. We address the importance of in-house sensor calibration and data acquisition sampling rate. Sensor calibration takes into account possible differences between calibration methodology in a manufacturing facility, and those used in the specific laboratory. We found in-house calibration factors of brand new sensors differ by less than 10% from their manufacturer supplied data. Larger differences were noticeable for sensors that have been used for hundreds of experiments and were as high as 30% for sensors close to the end of their useful lifetime...
2018: Frontiers in Neurology
https://www.readbyqxmd.com/read/29467276/neonatal-jaundice-improved-quality-and-cost-savings-after-implementation-of-a-standard-pathway
#18
Holly M Romero, Coral Ringer, Michael G Leu, Elaine Beardsley, Karen Kelly, Megan D Fesinmeyer, Wren L Haaland, James B Johnson, Darren Migita
OBJECTIVES: Seattle Children's Hospital sought to optimize the value equation for neonatal jaundice patients by creating a standard care pathway. METHODS: An evidence-based pathway for management of neonatal jaundice was created. This included multidisciplinary team assembly, comprehensive literature review, creation of a treatment algorithm and computer order sets, formulation of goals and metrics, roll-out of an education program for end users, and ongoing pathway improvement...
February 21, 2018: Pediatrics
https://www.readbyqxmd.com/read/29467086/the-application-of-moving-bed-bio-reactor-mbbr-in-commercial-laundry-wastewater-treatment
#19
Sławomira Bering, Jacek Mazur, Krzysztof Tarnowski, Magdalena Janus, Sylwia Mozia, Antoni Waldemar Morawski
Large, laboratory scale biological treatment tests of real industrial wastewater, generated in a large industrial laundry facility, was conducted from October 2014 to January 2015. This research sought to develop laundry wastewater treatment technology which included tests of a two-stage Moving Bed Bio Reactor (MBBR); this had two reactors, was filled with carriers Kaldnes K5 (specific area - 800 m2 /m3 ) and were realized in aerobic condition. Operating on site, in the laundry, reactors were fed actual wastewater from the laundry retention tank...
February 18, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29467056/review-integrating-a-semen-quality-control-program-and-sire-fertility-at-a-large-artificial-insemination-organization
#20
B R Harstine, M D Utt, J M DeJarnette
The technology available to assess sperm population characteristics has advanced greatly in recent years. Large artificial insemination (AI) organizations that sell bovine semen utilize many of these technologies not only for novel research purposes, but also to make decisions regarding whether to sell or discard the product. Within an AI organization, the acquisition, interpretation and utilization of semen quality data is often performed by a quality control department. In general, quality control decisions regarding semen sales are often founded on the linkages established between semen quality and field fertility...
February 22, 2018: Animal: An International Journal of Animal Bioscience
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