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https://www.readbyqxmd.com/read/29691962/gastrointestinal-symptoms-in-children-primary-care-and-specialist-interface
#1
REVIEW
Valeria Dipasquale, Domenico Corica, Simone M C Gramaglia, Simona Valenti, Claudio Romano
AIMS: Gastrointestinal symptoms and diseases represent one of the major reasons for paediatricians' requests for specialist consultations and hospital admissions. One fourth of annual medical consultations for children younger than 6 years can be attributed to gastrointestinal symptoms. High-quality guidelines have been validated worldwide to provide clinical recommendations and support healthcare providers' practice. Nevertheless, overall compliance to standards of care is unsatisfactory, and children with gastrointestinal symptoms frequently undergo expensive, useless specialist consultations and laboratory evaluations...
April 24, 2018: International Journal of Clinical Practice
https://www.readbyqxmd.com/read/29691099/influence-of-aortic-neck-characteristics-on-successful-aortic-wall-penetration-of-endoanchors-in-therapeutic-use-during-endovascular-aneurysm-repair
#2
Seline R Goudeketting, Kim van Noort, Kenneth Ouriel, William D Jordan, Jean M Panneton, Cornelis H Slump, Jean-Paul P M de Vries
OBJECTIVE: This study sought to quantify EndoAnchor (Medtronic Vascular, Santa Rosa, Calif) penetration into the aortic wall in patients undergoing endovascular abdominal aortic aneurysm repair and to assess predictors of successful penetration and its relationship to postprocedural type IA endoleak. METHODS: A subset of patients from the Aneurysm Treatment Using the Heli-FX Aortic Securement System Global Registry (ANCHOR) were included if they met the following criteria: the indication for EndoAnchor use was to treat a type IA endoleak, and postprocedure contrast-enhanced computed tomography (CT) scans of sufficient quality were available for core laboratory review...
April 21, 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29690749/landscape-of-actionable-genetic-alterations-profiled-from-1-071-tumor-samples-in-korean-cancer-patients
#3
Se-Hoon Lee, Boram Lee, Joon Ho Shim, Kwang Woo Lee, Jae Won Yun, Sook-Young Kim, Tae-You Kim, Yeul Hong Kim, Young Hyeh Ko, Hyun Cheol Chung, Chang Sik Yu, Jeeyun Lee, Sun Young Rha, Tae Won Kim, Kyung Hae Jung, Seock-Ah Im, Hyeong-Gon Moon, Sukki Cho, Jin Hyoung Kang, Jihun Kim, Sang Kyum Kim, Han Suk Ryu, Sang Yun Ha, Jong Il Kim, Yeun-Jun Chung, Cheolmin Kim, Hyung-Lae Kim, Woong-Yang Park, Dong-Young Noh, Keunchil Park
Purpose: With the emergence of next-generation sequencing (NGS) technology, profiling a wide range of genomic alterations has become a possibility resulting in improved implementation of targeted cancer therapy. In Asian populations, the prevalence and spectrum of clinically actionable genetic alterations has not yet been determined because of a lack of studies examining high-throughput cancer genomic data. Materials and Methods: To address this issue, 1,071 tumor samples were collected from five major cancer institutes in Korea and analyzed using targeted NGS at a centralized laboratory...
April 23, 2018: Cancer Research and Treatment: Official Journal of Korean Cancer Association
https://www.readbyqxmd.com/read/29689119/extended-criteria-donors-in-lung-transplantation-in-switzerland-an-evaluation-of-two-adapted-lung-donor-scores
#4
Andreas Elmer, Matthias Birrer, Julius Weiss, John-David Aubert, Christian Benden, Ilhan Inci, Thorsten Krüger, Paola M Soccal, Franz F Immer
AIM: Various scoring systems aim to assess the quality of organs donated for transplantation on the basis of patient characteristics, clinical examination and laboratory results. How well such scoring systems reflect the practice in lung transplantation in Switzerland has never been studied. Therefore, we evaluated two scoring systems for their ability to predict whether or not donor lungs are accepted by the two Swiss lung transplant centres. METHODS: We retrospectively analysed patient data of adult deceased organ donors in Switzerland between 1 July 2007 and 30 June 2014...
April 24, 2018: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29688963/how-to-optimally-fit-a-hearing-aid-for-bimodal-cochlear-implant-users-a-systematic-review
#5
Jantien L Vroegop, André Goedegebure, Marc P van der Schroeff
OBJECTIVES: Bimodal hearing has shown to improve speech recognition in quiet and in noise and to improve sound localization compared with unilateral cochlear implant (CI) use alone. Fitting the CI and hearing aid (HA) separately has been described well, but HA fitting procedures for bimodal CI users are not well researched or widely accepted. The aim of the present study was to systematically review the literature on the effect of different HA fitting strategies on auditory performance in bimodal CI users...
April 20, 2018: Ear and Hearing
https://www.readbyqxmd.com/read/29688884/measurement-uncertainty-and-metrological-traceability-of-whole-blood-cyclosporin-a-mass-concentration-results-obtained-by-uhplc-ms-ms
#6
Raül Rigo-Bonnin, Pedro Alía, Francesca Canalias
BACKGROUND: Traceable and accurate results of cyclosporine A (CsA) mass concentrations in whole blood are required to ensure the monitoring of immunosuppressive therapy in transplant recipients. Metrological traceability and measurement uncertainty can allow ensuring reliability and comparability of these results over time and space. In this study, we provide a practical and detailed example of how the traceability and uncertainty of mass concentration of CsA results, obtained using an ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS) procedure, can be described and estimated...
April 24, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29687240/simultaneous-assessment-of-cognitive-function-circadian-rhythm-and-spontaneous-activity-in-aging-mice
#7
Sreemathi Logan, Daniel Owen, Sixia Chen, Wei-Jen Chen, Zoltan Ungvari, Julie Farley, Anna Csiszar, Amanda Sharpe, Maarten Loos, Bastijn Koopmans, Arlan Richardson, William E Sonntag
Cognitive function declines substantially with age in both humans and animal models. In humans, this decline is associated with decreases in independence and quality of life. Although the methodology for analysis of cognitive function in human models is relatively well established, similar analyses in animal models have many technical issues (e.g., unintended experimenter bias, motivational issues, stress, and testing during the light phase of the light dark cycle) that limit interpretation of the results. These caveats, and others, potentially bias the interpretation of studies in rodents and prevent the application of current tests of learning and memory as part of an overall healthspan assessment in rodent models of aging...
April 24, 2018: GeroScience
https://www.readbyqxmd.com/read/29686982/maternal-death-in-rural-ghana-a-case-study-in-the-upper-east-region-of-ghana
#8
Paschal Awingura Apanga, John Koku Awoonor-Williams
Maternal mortality remains a challenge in providing quality maternal and other reproductive healthcare services in Ghana. This is a case investigation of a maternal death in rural Ghana that seeks to unravel the circumstances that lead to her death. We conducted three in-depth interviews with healthcare staff as well as a focused group discussion comprising of six relatives of the deceased, including her husband. The investigation revealed that lack of logistics, medical, and laboratory equipment, inadequate knowledge about the benefits of antenatal care services as well as non-adherence of healthcare workers to treatment protocols and standard operating procedures were found as major setbacks to the provision of effective and quality maternal healthcare services in Ghana...
2018: Frontiers in Public Health
https://www.readbyqxmd.com/read/29685874/impact-of-oral-side-effects-from-conditioning-therapy-before-hematopoietic-stem-cell-transplantation-protocol-for-a-multicenter-study
#9
Michael T Brennan, Bengt Hasséus, Allan J Hovan, Judith E Raber-Durlacher, Nicole Ma Blijlevens, Marie-Charlotte Huysmans, Karin Garming Legert, Jan-Erik Johansson, Charity G Moore, Inger von Bültzingslöwen
BACKGROUND: The oral cavity is a common site of complications related to the cytotoxic effect of high-dose chemotherapy and radiation therapy. Considering our limited understanding of the burden of illness in the oral cavity from various cytotoxic therapies, it is difficult to produce evidence-based, preventive and management protocols. A prospective multicenter study is necessary to collect data on the burden of illness from various cytotoxic regimens. OBJECTIVE: The objectives of this prospective international observational multicenter study in hematopoietic stem cell transplant (HSCT) patients are to establish the nature, incidence and temporal relationship of oral complications related to conditioning regimens (chemotherapy with or without total body irradiation), stem cell transplantation and the immunologic reactions (mainly graft-vs-host-disease) that may follow, and to determine what subjective and objective oral complications related to treatment can predict negative clinical and economic outcomes and reduced quality of life...
April 23, 2018: JMIR Research Protocols
https://www.readbyqxmd.com/read/29685247/guidelines-for-hospital-privileges-in-vascular-surgery-and-endovascular-interventions-recommendations-of-the-society-for-vascular-surgery
#10
Keith D Calligaro, Kwame S Amankwah, Marcus D'Ayala, O William Brown, Paul Steven Collins, Mohammad H Eslami, Krishna M Jain, Daniel S Kassavin, Brandon Propper, Timur P Sarac, William P Shutze, Thomas H Webb
The Hospital Privileges Practice Guideline Writing Group of the Society for Vascular Surgery is making the following five recommendations concerning guidelines for hospital privileges for vascular surgery and endovascular therapy. Advanced endovascular procedures are currently entrenched in the everyday practice of specialized vascular interventionalists, including vascular surgeons, but open vascular surgery remains uniquely essential to the specialty. First, we endorse the Residency Review Committee for Surgery recommendations regarding open and endovascular cases during vascular residency and fellowship training...
May 2018: Journal of Vascular Surgery
https://www.readbyqxmd.com/read/29684824/a-review-of-human-biomonitoring-in-selected-southeast-asian-countries
#11
REVIEW
Zohar Barnett-Itzhaki, Marta Esteban López, Naveen Puttaswamy, Tamar Berman
Rapid development and industrialization in Southeast (SE) Asia has led to environmental pollution, potentially exposing the general population to environmental contaminants. Human biomonitoring (HBM), measurement of chemical and/or their metabolites in human tissues and fluids, is an important tool for assessing cumulative exposure to complex mixtures of chemicals and for monitoring chemical exposures in the general population. While there are national HBM programs in several developed countries, there are no such national programs in most of the SE Asian countries...
April 20, 2018: Environment International
https://www.readbyqxmd.com/read/29684367/commutability-and-traceability-in-eqa-programs
#12
Tony Badrick, Wilson Punyalack, Peter Graham
OBJECTIVES: The concept of commutability of samples has focused laboratories on the importance of traceability. However, the critical role of External Quality Assurance (EQA) in achieving the primary role of traceability (i.e. facilitating comparable patient results in different laboratories) has largely been lost. The aim of this paper is to review the role of EQA in achieving traceable results. DESIGN AND METHODS: The role of commutability and traceability in EQA and Internal Quality Control (IQC) are discussed...
April 20, 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29683797/uncertainty-evaluation-in-clinical-chemistry-immunoassay-hematology-and-coagulation-analytes-using-only-external-quality-assessment-data
#13
Yanyan Qin, Rui Zhou, Wei Wang, Hongyi Yin, Yanmin Yang, Yuhong Yue, Qing Tong, Lu Liu, Yali Jin, Yankun Shi, Shunli Zhang, Jianping Zhang, Rui Zhang, Chang Zuo, Tingting Jia, Ning Wang, Qingtao Wang
BACKGROUND: Measurement uncertainty (MU) is a parameter associated with the result of a measurement that characterizes its dispersion. We report results for estimating MU following the application of a top-down procedure using only proficiency test data to establish uncertainty levels for various analytes. METHODS: Data were obtained from 142 laboratories participating in the Beijing Center for Clinical Laboratory (BCCL) proficiency testing/external quality assessment (PT/EQA) schemes...
April 23, 2018: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/29683219/response-of-consumer-and-research-grade-indoor-air-quality-monitors-to-residential-sources-of-fine-particles
#14
Brett C Singer, William W Delp
The ability to inexpensively monitor PM2.5 to identify sources and enable controls would advance residential indoor air quality (IAQ) management. Consumer IAQ monitors incorporating low-cost optical particle sensors and connections with smart home platforms could provide this service if they reliably detect PM2.5 in homes. In this study, particles from typical residential sources were generated in a 120 m3 laboratory and time-concentration profiles were measured with seven consumer monitors (2-3 units each), two research monitors (Thermo pDR-1500, MetOne BT-645), a Grimm Mini Wide-Range Aerosol Spectrometer (GRM), and a Tapered Element Oscillating Microbalance with Filter Dynamic Measurement System (FDMS), a federal equivalent method (FEM) for PM2...
April 23, 2018: Indoor Air
https://www.readbyqxmd.com/read/29681159/bullous-pemphigoid-a-10-year-study-of-discordant-results-on-direct-immunofluorescence
#15
Jessica G Fudge, Richard I Crawford
BACKGROUND: Bullous pemphigoid (BP) is the most common subepidermal autoimmune disorder characterized by tense bullae. It is associated with circulating autoantibodies against BP antigen-1 and BP antigen-2. Diagnosis is based upon clinical, histopathologic, and immunopathologic examination. Direct immunofluorescence (DIF) of perilesional skin highlights C3 with or without IgG in a linear pattern along the basement membrane. OBJECTIVES: We hypothesized that repeat biopsies may be required for a definitive DIF diagnosis of BP, as initial DIF evaluation may result in a false-negative result...
April 1, 2018: Journal of Cutaneous Medicine and Surgery
https://www.readbyqxmd.com/read/29681058/the-physcomitrella-patens-gene-atlas-project-large-scale-rna-seq-based-expression-data
#16
Pierre-François Perroud, Fabian B Haas, Manuel Hiss, Kristian K Ullrich, Alessandro Alboresi, Mojgan Amirebrahimi, Kerrie Barry, Roberto Bassi, Sandrine Bonhomme, Haodong Chen, Juliet Coates, Tomomichi Fujita, Anouchka Guyon-Debast, Daniel Lang, Junyan Lin, Anna Lipzen, Fabien Nogué, Melvin J Oliver, Inés Ponce de León, Ralph S Quatrano, Catherine Rameau, Bernd Reiss, Ralf Reski, Mariana Ricca, Younousse Saidi, Ning Sun, Peter Szövényi, Avinash Sreedasyam, Jane Grimwood, Gary Stacey, Jeremy Schmutz, Stefan A Rensing
High throughput RNA sequencing (RNA-seq) has recently become the method of choice to define and analyse transcriptomes. For the model moss Physcomitrella patens, although this method has been used to help the analysis of specific perturbations, no overall reference dataset has been established yet. In the framework of its Gene Atlas project, the Joint Genome Institute selected P. patens as a flagship genome, opening the way to generate the first comprehensive transcriptome dataset for this moss. The first round of sequencing described here is composed of 99 independent libraries spanning 34 different developmental stages and conditions...
April 22, 2018: Plant Journal: for Cell and Molecular Biology
https://www.readbyqxmd.com/read/29680761/vitrified-medical-wastes-bottom-ash-in-cement-clinkerization-microstructural-hydration-and-leaching-characteristics
#17
S Papamarkou, D Christopoulos, P E Tsakiridis, G Bartzas, K Tsakalakis
The present investigation focuses on the utilization of medical wastes incineration bottom ash (MBA), vitrified with soda lime recycled glass (SLRG), as an alternative raw material in cement clinkerization. Bottom ash is recovered from the bottom of the medical wastes incineration chamber, after being cooled down through quenching. It corresponds to 10-15 wt% of the initial medical wastes weight and since it has been classified in the category of hazardous wastes, its safe management has become a major environmental concern worldwide...
April 19, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29680756/do-constructed-wetlands-remove-metals-or-increase-metal-bioavailability
#18
Xiaoyu Xu, Gary L Mills
The H-02 wetland was constructed to treat building process water and storm runoff water from the Tritium Processing Facility on the Department of Energy's Savannah River Site (Aiken, SC). Monthly monitoring of copper (Cu) and zinc (Zn) concentrations and water quality parameters in surface waters continued from 2014 to 2016. Metal speciation was modeled at each sampling occasion. Total Cu and Zn concentrations released to the effluent stream were below the NPDES limit, and the average removal efficiency was 65...
April 19, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29680495/novel-absorptivity-centering-method-utilizing-normalized-and-factorized-spectra-for-analysis-of-mixtures-with-overlapping-spectra-in-different-matrices-using-built-in-spectrophotometer-software
#19
Hayam Mahmoud Lotfy, Yasmin Rostom Omran
A novel, simple, rapid, accurate, and economical spectrophotometric method, namely absorptivity centering (a-Centering) has been developed and validated for the simultaneous determination of mixtures with partially and completely overlapping spectra in different matrices using either normalized or factorized spectrum using built-in spectrophotometer software without a need of special purchased program. Mixture I (Mix I) composed of Simvastatin (SM) and Ezetimibe (EZ) is the one with partial overlapping spectra formulated as tablets, while mixture II (Mix II) formed by Chloramphenicol (CPL) and Prednisolone acetate (PA) is that with complete overlapping spectra formulated as eye drops...
April 7, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29680426/willis-ekbom-disease-restless-legs-syndrome-in-patients-with-opioid-withdrawal
#20
Ravi Gupta, Ramjan Ali, Rajat Ray
INTRODUCTION: Many patients with opioid use disorder report symptoms similar to restless legs syndrome (RLS) during withdrawal. However, whether these symptoms are true RLS, their predictors and effect of treatment with pregabalin are still unknown. METHOD: A total of 19 consecutive patients with opioid use disorder who were admitted for detoxification were included in this study after obtaining informed consent. Information regarding addiction was noted, and they were screened for RLS every morning and evening...
May 2018: Sleep Medicine
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