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JOURNAL ARTICLE
Bernhard Scharinger, Elke Boxhammer, Richard Rezar, Stefan Hecht, Sarah Wernly, Tobias Widhalm, Michael Lichtenauer, Uta C Hoppe, Klaus Hergan, Bernhard Wernly, Bernhard Strohmer, Reinhard Kaufmann
Purpose To perform a systematic review to assess the diagnostic and prognostic value of cardiac MRI after sudden cardiac arrest (SCA). Materials and Methods PubMed and Cochrane Library databases were systematically searched for studies investigating cardiac MRI after SCA in adult patients (≥18 years of age). The time frame of the encompassed studies spans from January 2012 to January 2023. The study protocol was preregistered in OSF Registries (www.osf.io/nxaev) , and the systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines...
April 2024: Radiology. Cardiothoracic imaging
#2
JOURNAL ARTICLE
Nicoline Bebe Mortensen, Kristine Bjørndal
BACKGROUND: Facial nerve palsy is a potential complication of parotidectomy for benign salivary gland tumours, necessitating a comprehensive understanding of its incidence and associated risk factors for improved patient counselling and preoperative planning. AIM/OBJECTIVES: This single-centre retrospective study aimed to assess the rate of facial nerve palsy following benign parotidectomy at a University Teaching Hospital. MATERIAL AND METHODS: Over a 3-year period, 160 patients undergoing parotid surgery for benign tumours were included...
April 18, 2024: Acta Oto-laryngologica
#3
Javeed Iqbal, Muhammad Mohsin Khan, Abdulnasser Thabet, Kazim Mohammed, Gianluca Scalia, Bipin Chaurasia
KEY CLINICAL MESSAGE: Successful management of cervical tuberculosis and severe kyphosis was achieved using a PEEK expandable cage and titanium plate, demonstrating favorable outcomes in restoring cervical alignment and stability. This approach represents a promising alternative for addressing complex cervical pathologies, highlighting the potential of PEEK-based interventions in surgical management. ABSTRACT: Cervical tuberculosis can lead to severe vertebral destruction and kyphosis, posing challenges in surgical management...
April 2024: Clinical Case Reports
#4
Suyu Gu, Yuting Liu, Yufan Huang, Wenzheng Lin, Ke Li
BACKGROUND: In recent years, novel therapies targeting specific molecular pathways and immunotherapies have exhibited promising outcomes for treating human epidermal growth factor receptor 2 (HER2)-positive breast cancer. Our work aimed to assess the effectiveness and safety of these emerging treatment regimens for this disease. MATERIAL AND METHODS: We systematically searched databases including PubMed, Embase, Web of Science, and the Cochrane Central Register of Controlled Trials their inception to August 2023 to identify relevant randomized controlled trials (RCTs)...
2024: Frontiers in Oncology
#5
JOURNAL ARTICLE
Catarina Correia, Nuno Almeida, Raquel Andrade, Mariana Sant'Anna, Cláudia Macedo, David Perdigoto, Carlos Gregório, Pedro Narra Figueiredo
INTRODUCTION: According to the guideline published by ESGE/UEG, a high-quality esophagogastroduodenoscopy (EGD) implies the application of some criteria that enable better healthcare outcomes. Although intra-procedural performance measures are dependent on patient factors, there is no reference to sedation practices in the guideline mentioned above. OBJECTIVE: This study aimed to evaluate whether deep sedation influences EGD performance measures established by ESGE/UEG...
April 2024: GE Portuguese Journal of Gastroenterology
#6
JOURNAL ARTICLE
Amjad Ali Bacha, Muhammad Suhail, Fuad A Awwad, Emad A A Ismail, Hijaz Ahmad
Dietary fiber has an immense role in the gut microbiome by modulating juvenile growth, immune system maturation, glucose, and lipid metabolism. Lifestyle changes might disrupt gut microbiota symbiosis, leading to various chronic diseases with underlying inflammatory conditions, obesity, and its associated pathologies. An interventional study of 16 weeks examined the impact of psyllium husk fiber with and without lifestyle modification on gut health and sleep quality in people with central obesity (men = 60 and women = 60), those aged from 40 to 60 years, those having WC ≥ 90 cm (men) and WC ≥ 80 cm (women), and no history of any chronic disease or regular medication...
2024: Frontiers in Nutrition
#7
JOURNAL ARTICLE
Zeinab Z Khater, Hend Sh Ghareeb
BACKGROUND: One of the most challenging pests to control is the wild rat ( Rattus norvegicus ), which poses serious risks to both human health and the economy. Fertilizers are a more recent method of pest management with various action modes and are considered safe control agents when applied at low doses. AIM: The present study aimed to examine the toxicological impacts of the contaminated water with urea and camphor oil individually, post-treatment of rats with camphor oil after the pre-treatment with urea and post-treatment of rats with urea mixed with camphor oil after urea pre-treatment against the wild rats ( R...
January 2024: Open Veterinary Journal
#8
JOURNAL ARTICLE
Maryam Mehdizadeh, Sajib Saha, David Alonso-Caneiro, Jason Kugelman, Cara MacNish, Fred Chen
OCT is a widely used clinical ophthalmic imaging technique, but the presence of speckle noise can obscure important pathological features and hinder accurate segmentation. This paper presents a novel method for denoising optical coherence tomography (OCT) images using a combination of texture loss and generative adversarial networks (GANs). Previous approaches have integrated deep learning techniques, starting with denoising Convolutional Neural Networks (CNNs) that employed pixel-wise losses. While effective in reducing noise, these methods often introduced a blurring effect in the denoised OCT images...
April 1, 2024: Biomedical Optics Express
#9
REVIEW
Jean-François Huon, Pierre Nizet, Sophie Tollec, Elise Vene, Clémentine Fronteau, Alison Leichnam, Martine Tching-Sin, Vanessa Michelet-Barbotin, Laura Foucault-Fruchard, Fabien Nativel
BACKGROUND: Although confidence does not automatically imply competence, it does provide pharmacy students with a sense of empowerment to manage a pharmacotherapeutic problem independently. Among the methods used in higher education, there is growing interest in simulation. AIM: To evaluate the impact of simulation on pharmacy students' confidence in performing clinical pharmacy activities. METHOD: Articles that reported the use of simulation among pharmacy students with fully described outcomes about confidence were included...
April 17, 2024: International Journal of Clinical Pharmacy
#10
REVIEW
Tariq Kewan, Maximillian Stahl, Jan Philipp Bewersdorf, Amer M Zeidan
PURPOSE OF REVIEW: Myelodysplastic syndromes/neoplasms (MDS) represent a diverse group of pathologically distinct diseases with varying prognoses and risks of leukemia progression. This review aims to discuss current treatment options for elderly patients with MDS, focusing on patients ineligible for intensive chemotherapy or allogenic hematopoietic stem cell transplantation (HSCT). The challenges associated with treatment in this population and emerging therapeutic prospects are also explored...
April 18, 2024: Current Hematologic Malignancy Reports
#11
JOURNAL ARTICLE
Julie K Wisch, Nicole S McKay, Anna H Boerwinkle, James Kennedy, Shaney Flores, Benjamin L Handen, Bradley T Christian, Elizabeth Head, Mark Mapstone, Michael S Rafii, Sid E O'Bryant, Julie C Price, Charles M Laymon, Sharon J Krinsky-McHale, Florence Lai, H Diana Rosas, Sigan L Hartley, Shahid Zaman, Ira T Lott, Dana Tudorascu, Matthew Zammit, Adam M Brickman, Joseph H Lee, Thomas D Bird, Annie Cohen, Patricio Chrem, Alisha Daniels, Jasmeer P Chhatwal, Carlos Cruchaga, Laura Ibanez, Mathias Jucker, Celeste M Karch, Gregory S Day, Jae-Hong Lee, Johannes Levin, Jorge Llibre-Guerra, Yan Li, Francisco Lopera, Jee Hoon Roh, John M Ringman, Charlene Supnet-Bell, Christopher H van Dyck, Chengjie Xiong, Guoqiao Wang, John C Morris, Eric McDade, Randall J Bateman, Tammie L S Benzinger, Brian A Gordon, Beau M Ances
BACKGROUND: In people with genetic forms of Alzheimer's disease, such as in Down syndrome and autosomal-dominant Alzheimer's disease, pathological changes specific to Alzheimer's disease (ie, accumulation of amyloid and tau) occur in the brain at a young age, when comorbidities related to ageing are not present. Studies including these cohorts could, therefore, improve our understanding of the early pathogenesis of Alzheimer's disease and be useful when designing preventive interventions targeted at disease pathology or when planning clinical trials...
May 2024: Lancet Neurology
#12
JOURNAL ARTICLE
Daniel D Mais, Alia N Nazarullah, Anthony J Guidi, Suzanne Dintzis, Barbara J Blond, Thomas A Long, Suzanne N Coulter, Richard W Brown
CONTEXT.—: Laboratories performing predictive marker testing for breast carcinoma are encouraged to compare patient results to published benchmarks. OBJECTIVE.—: To collect expression rates for estrogen receptor (ER), progesterone receptor (PgR), and human epidermal growth factor receptor 2 (HER2) in invasive breast carcinoma from multiple laboratories. DESIGN.—: Participants submitted data from up to 50 primary cases during the study period...
April 18, 2024: Archives of Pathology & Laboratory Medicine
#13
JOURNAL ARTICLE
Yan Li, Yan-Tong Zhang, Bing Han, Lan Xue, Yan Wei, Ge Li
PURPOSE: Smooth muscle cell (SMC) dysregulation is part of the pathological basis of pulmonary artery hypertension (PAH). We aimed to explore the heterogeneity of SMCs in PAH. METHODS: The profile GSE210248 was obtained from NCBI Gene Expression Omnibus, containing the scRNA-seq data of pulmonary arteries (PA) from three patients with PAH and three healthy donors. After quality control, normalization, and dimension reduction, cell clustering analysis was performed...
April 15, 2024: Advances in Medical Sciences
#14
JOURNAL ARTICLE
Joanne Howells, Lisa Maria, Taryn Shirkey, Ari Carrington, Henry S Lane
Disease is a major threat to the economic, ecological and cultural services provided by wild bivalve populations. Over the past decade anecdotal reports on declining health of native bivalve populations around Aotearoa New Zealand have been supported by increasing observations of mass die-offs. Causes of declining health and mass die-offs of wild bivalves are not clear and could be due to a number of interactive and cumulative factors, including declining water quality, climate change, or disease. Pipi/kōkota (Paphies australis) within the Whangārei area (northern New Zealand) have suffered repeated die-offs and declining health since at least 2009...
April 15, 2024: Journal of Invertebrate Pathology
#15
JOURNAL ARTICLE
Bilal Murtaza, Xiaoyu Li, Muhammad Yasir Nawaz, Muhammad Kashif Saleemi, Gen Li, Bowen Jin, Lili Wang, Yongping Xu
Mycotoxins, ubiquitous contaminants in food, present a global threat to human health and well-being. Mitigation efforts, such as the implementation of sound agricultural practices, thorough food processing, and the advancement of mycotoxin control technologies, have been instrumental in reducing mycotoxin exposure and associated toxicity. To comprehensively assess mycotoxins and their toxicodynamic implications, the deployment of effective and predictive strategies is imperative. Understanding the manner of action, transformation, and cumulative toxic effects of mycotoxins, moreover, their interactions with food matrices can be gleaned through gene expression and transcriptome analyses at cellular and molecular levels...
May 2024: Comprehensive Reviews in Food Science and Food Safety
#16
JOURNAL ARTICLE
Wei Wang, Kaicheng Shen, Ruyan Liu, Qi Zhou
BACKGROUND: Osteolytic bone metastasis is a common complication of Non-Small Cell Lung Cancer (NSCLC), resulting in bone pain, hypercalcemia, and fractures that severely reduce the quality of life and survival time of patients. Semaphorins 3A (Sema3A) is one of the isoforms of the Semaphorins family, which is important in a variety of physiological and pathological processes, such as angiogenesis, immune regulation, and tumorigenesis. However, the role of Sema3A in the development of osteolytic bone metastasis in NSCLC is unknown...
April 15, 2024: Recent Patents on Anti-cancer Drug Discovery
#17
REVIEW
Matteo Perrino, Emanuele Voulaz, Simone Balin, Gerardo Cazzato, Elena Fontana, Sara Franzese, Martina Defendi, Fabio De Vincenzo, Nadia Cordua, Roberto Tamma, Federica Borea, Marta Aliprandi, Marco Airoldi, Luigi Giovanni Cecchi, Roberta Fazio, Marco Alloisio, Giuseppe Marulli, Armando Santoro, Luca Di Tommaso, Giuseppe Ingravallo, Laura Russo, Giorgio Da Rin, Anna Villa, Silvia Della Bella, Paolo Andrea Zucali, Domenico Mavilio
Thymic epithelial tumors (TETs) are rare mediastinal cancers originating from the thymus, classified in two main histotypes: thymoma and thymic carcinoma (TC). TETs affect a primary lymphoid organ playing a critical role in keeping T-cell homeostasis and ensuring an adequate immunological tolerance against "self". In particular, thymomas and not TC are frequently associated with autoimmune diseases (ADs), with Myasthenia Gravis being the most common AD present in 30% of patients with thymoma. This comorbidity, in addition to negatively affecting the quality and duration of patients' life, reduces the spectrum of the available therapeutic options...
2024: Frontiers in Immunology
#18
JOURNAL ARTICLE
Simone Tassani, Paula Chaves, Marc Beardsley, Milica Vujovic, Juan Ramírez, Jimena Mendoza, Marta Portero-Tresserra, Miguel Angel González-Ballester, Davinia Hernández-Leo
OBJECTIVE: This study aims to test the hypothesis that breathing can be directly linked to postural stability and psychological health. A protocol enabling the simultaneous analysis of breathing, posture, and emotional levels in university students is presented. This aims to verify the possibility of defining a triangular link and to test the adequacy of various measurement techniques. PARTICIPANTS AND PROCEDURE: Twenty-three subjects (9 females and 14 males), aged between 18 and 23 years, were recruited...
2024: Frontiers in Bioengineering and Biotechnology
#19
JOURNAL ARTICLE
Romain Darriaut, Tania Marzari, Vincent Lailheugue, Joseph Tran, Guilherme Martins, Elisa Marguerit, Isabelle Masneuf-Pomarède, Virginie Lauvergeat
When grapevine decline, characterized by a premature decrease in vigor and yield and sometimes plant death, cannot be explained by pathological or physiological diseases, one may inquire whether the microbiological status of the soil is responsible. Previous studies have shown that the composition and structure of bacterial and fungal microbial communities in inter-row soil are affected in areas displaying vine decline, compared to areas with non-declining vines within the same plot. A more comprehensive analysis was conducted in one such plot...
2024: Frontiers in Plant Science
#20
REVIEW
Kathryn W Ruckart, Mark McKone, Jacline G Phillips, Maris O Krekelberg, K Annalize Sussman, Lyndsay L Madden
OBJECTIVE: This scoping review aims to provide an overview of the literature investigating the efficacy of speech-language pathology (SLP) interventions in the treatment of globus pharyngeus (GP), identify gaps in knowledge, and guide future research. STUDY DESIGN: Scoping review. METHODS: Search terms were selected for five databases (PubMed, Embase, Web of Science, CINAHL, and Google Scholar). Inclusion criteria were broad and focused on any SLP intervention used to treat GP...
April 15, 2024: Journal of Voice
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