Mingzheng Li, Dan Li, Yucan Jiang, Ping He, Yeming Li, Yan Wu, Wei Lei, Joost D de Bruijn, Richard D Cannon, Li Mei, Hua Zhang, Ping Ji, Hongmei Zhang, Huipin Yuan
Osteoinductive materials are characterized by their ability to induce bone formation in ectopic sites. Thus, osteoinductive materials hold promising potential for repairing bone defects. However, the mechanism of material-induced bone formation remains unknown, which limits the design of highly potent osteoinductive materials. Here, we demonstrated a genetic background link among macrophage polarization, osteoclastogenesis and material-induced bone formation. The intramuscular implantation of an osteoinductive material in FVB/NCrl (FVB) mice resulted in more M2 macrophages at week 1, more osteoclasts at week 2 and increased bone formation after week 4 compared with the results obtained in C57BL/6JOlaHsd (C57) mice...
October 17, 2023: Biomaterials