keyword
MENU ▼
Read by QxMD icon Read
search

uterine nk cells

keyword
https://www.readbyqxmd.com/read/28098245/natural-cytotoxicity-receptor-1-in-mouse-unk-cell-maturation-and-function
#1
A M Felker, B A Croy
Early and midgestational decidua of mice genetically ablated for expression of the natural killer (NK) cell natural cytotoxicity receptor (NCR; Ncr1(Gfp/Gfp) mice) shows restricted angiogenesis and atypically small uterine (u)NK cells . We hypothesized that NCR1 inactivation disturbs maturation and angiokine production by uterine natural killer (uNK) cells. Using histological and morphometric approaches, we observed that Ncr1(Gfp/Gfp) but not control C57BL/6 (B6) implantation sites sustain immature, non-granulated uNK cells into midpregnancy...
January 18, 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/28069185/combination-of-uterine-natural-killer-cell-immunoglobulin-receptor-haplotype-and-trophoblastic-hla-c-ligand-influences-the-risk-of-pregnancy-loss-a-retrospective-cohort-analysis-of-direct-embryo-genotyping-data-from-euploid-transfers
#2
Scott J Morin, Nathan R Treff, Xin Tao, Richard T Scott, Jason M Franasiak, Caroline R Juneau, Marcy Maguire, Richard T Scott
OBJECTIVE: To compare maternal uterine natural killer cell immunoglobulin receptor (KIR) genotype and haplotype frequencies between patients whose euploid single-embryo transfer resulted in pregnancy loss and those that resulted in delivery and to determine if the risk of pregnancy loss was affected by the HLA-C genotype content in the embryo. DESIGN: Retrospective cohort. SETTING: Academic research center. PATIENT(S): Autologous fresh IVF cycles resulting in positive serum β-hCG during 2009-2014...
January 6, 2017: Fertility and Sterility
https://www.readbyqxmd.com/read/28045093/increased-uterine-nk-cell-numbers-and-perforin-expression-during-the-implantation-phase-in-ivf-cycles-with-gnrh-antagonist-protocol
#3
Bufang Xu, Jingwen Wang, Lan Xia, Dan Zhang, Xian Wu, Aijun Zhang
GnRH antagonist negatively affects endometrial receptivity in in vitro fertilization (IVF) cycles, however, its underlying mechanism remains unclear. To explore its target molecules, we studied endometria in the window phase of fixed GnRH antagonist, low-dose flexible GnRH antagonist, GnRH agonist long protocol, and untreated control groups. There were 384 differentially expressed genes (DEGs) in the fixed antagonist group with greater than twofold expression change compared with the control group and 197 DEGs between the fixed antagonist and agonist groups, the majority of which were associated with the natural killer (NK) cell-mediated cytotoxicity pathway...
January 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28043035/pibf-positive-uterine-nk-cells-in-the-mouse-decidua
#4
Agnes Bogdan, Gergely Berta, Julia Szekeres-Bartho
: Though uterine NK cells (u NK cells) contain cytotoxic granules, and selectively over- express the genes of perforin and granzymes, during normal pregnancy, they are not cytotoxic. Progesterone is indispensable for the establishment and maintenance of pregnancy both in humans and in mice. Mouse uterine NK cells do not express the classical progesterone receptor, yet progesterone affects the recruitment and function of uterine NK cells, the latter partly via the Progesterone-Induced Blocking Factor (PIBF)...
December 23, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27940158/inactivation-of-maternal-hif-1%C3%AE-at-mid-pregnancy-causes-placental-defects-and-deficits-in-oxygen-delivery-to-the-fetal-organs-under-hypoxic-stress
#5
Doreswamy Kenchegowda, Bryony Natale, Maria A Lemus, David R Natale, Steven A Fisher
A critical transition occurs near mid-gestation of mammalian pregnancy. Prior to this transition, low concentrations of oxygen (hypoxia) signaling through Hypoxia Inducible Factor (HIF) functions as a morphogen for the placenta and fetal organs. Subsequently, functional coupling of the placenta and fetal cardiovascular system for oxygen (O2) transport is required to support the continued growth and development of the fetus. Here we tested the hypothesis that Hif-1α is required in maternal cells for placental morphogenesis and function...
December 9, 2016: Developmental Biology
https://www.readbyqxmd.com/read/27905000/decidual-natural-killer-cells-and-the-immune-microenvironment-at-the-maternal-fetal-interface
#6
REVIEW
Binqing Fu, Haiming Wei
During early pregnancy, an orchestrated evolutionary maternal adaption toward tolerance of the semiallogeneic fetus is required to ensure decidualization and early embryo development. Remodeling of the immune system involves natural killer cells (NKs), macrophages, T cells and dendritic cells (DCs) altering the microenvironment in the deciduas. In particular, a unique population of NK cells with a CD56(bright)CD16(-) phenotype in the decidua has been proposed to play a key role in the maternal adaptation to pregnancy...
December 2016: Science China. Life Sciences
https://www.readbyqxmd.com/read/27865124/the-killer-cell-story-in-recurrent-miscarriage-association-between-activated-peripheral-lymphocytes-and-uterine-natural-killer-cells
#7
R J Kuon, K Vomstein, M Weber, F Müller, C Seitz, S Wallwiener, T Strowitzki, E Schleussner, U R Markert, V Daniel, B Toth
Peripheral and uterine NK cells (pNK, uNK) can be distinguished according to their receptor expression. Recent studies indicate an association of elevated pNK and uNK with recurrent miscarriage (RM). This study aimed to analyze pNK and uNK in patients with RM and healthy controls. Out of n=590 RM patients screened according to a standard diagnostic protocol, n=268 couples with ≥3 consecutive RM were identified. Subgroups consisted of n=151 primary RM (pRM), n=85 secondary RM (sRM), n=32 tertiary RM (tRM) and n=42 healthy controls...
November 6, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27860312/cytochrome-p450-26a1-modulates-natural-killer-cells-in-mouse-early-pregnancy
#8
Chao-Yang Meng, Zhong-Yin Li, Wen-Ning Fang, Zhi-Hui Song, Dan-Dan Yang, Dan-Dan Li, Ying Yang, Jing-Pian Peng
Cytochrome P450 26A1 (CYP26A1) has a spatiotemporal expression pattern in the uterus, with a significant increase in mRNA and protein levels during peri-implantation. Inhibiting the function or expression of CYP26A1 can cause pregnancy failure, suggesting an important regulatory role of CYP26A1 in the maintenance of pregnancy. However, little is known about the exact mechanism involved. In this study, using a pCR3.1-cyp26a1 plasmid immunization mouse model and a Cyp26a1-MO (Cyp26a1-specific antisense oligos) knockdown mouse model, we report that the number of Dolichos biflorus agglutinin (DBA) lectin-positive uterine natural killer (uNK) cells was reduced in pCR3...
November 17, 2016: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/27815424/activating-kir2ds4-is-expressed-by-uterine-nk-cells-and-contributes-to-successful-pregnancy
#9
Philippa R Kennedy, Olympe Chazara, Lucy Gardner, Martin A Ivarsson, Lydia E Farrell, Shiqiu Xiong, Susan E Hiby, Francesco Colucci, Andrew M Sharkey, Ashley Moffett
Tissue-specific NK cells are abundant in the pregnant uterus and interact with invading placental trophoblast cells that transform the maternal arteries to increase the fetoplacental blood supply. Genetic case-control studies have implicated killer cell Ig-like receptor (KIR) genes and their HLA ligands in pregnancy disorders characterized by failure of trophoblast arterial transformation. Activating KIR2DS1 or KIR2DS5 (when located in the centromeric region as in Africans) lower the risk of disorders when there is a fetal HLA-C allele carrying a C2 epitope...
December 1, 2016: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/27792886/tim-3-expression-on-immune-cells-and-roles-at-the-maternal-fetal-interface
#10
REVIEW
Xiao-Hui Hu, Mao-Xing Tang, Gil Mor, Ai-Hua Liao
Successful pregnancy relies on the accurate regulation of the maternal-fetal immune system. Without enough tolerance in the uterine microenvironment, the mother and the hemiallogeneic fetus could not peacefully coexist. T cell immunoglobulin and mucin domain (Tim)-3 is a molecule originally regarded as to be expressed on terminally differentiated IFN-γ expressing CD4(+) T cells (Th1). The engagement of Tim-3 with its ligand, galectin-9 (Gal-9) could induce the exhaustion or apoptosis of effector T cells, and thus might regulate the tolerance...
October 20, 2016: Journal of Reproductive Immunology
https://www.readbyqxmd.com/read/27780537/bone-mesenchymal-stem-cells-improve-pregnancy-outcome-by-inducing-maternal-tolerance-to-the-allogeneic-fetus-in-abortion-prone-matings-in-mouse
#11
Yu-Han Meng, Xiao-Hui Zhu, Li-Ying Yan, Yan Zhang, Hong-Yan Jin, Xi Xia, Rong Li, Jie Qiao
INTRODUCTION: The successful pregnancy depends on maternal immune tolerance against the fetus. It has been reported that MSCs (mesenchymal stem cells) could play a regulatory role on immune cells such as CD4(+)T cells, macrophages and NK cells, but their effect on recurrent miscarriage is unknown. STUDY DESIGN: In a prospective study, the abortion-prone (CBA/J × DBA/2) H-2(d) × H-2(k) mice were utilized. Female CBA/J mice (8-10 weeks old) were injected with vehicle or MSCs via tail vein or uterine horns, and 14 days later, they were mated with DBA/2 males for the following experiments...
November 2016: Placenta
https://www.readbyqxmd.com/read/27751789/variation-of-maternal-kir-and-fetal-hla-c-genes-in-reproductive-failure-too-early-for-clinical-intervention
#12
Ashley Moffett, Olympe Chazara, Francesco Colucci, Martin H Johnson
A distinctive type of (uterine) natural killer (NK) cell is present in the uterine decidua during the period of placental formation. Uterine NK cells express members of the killer immunoglobulin-like receptor (KIR) family that bind to parental HLA-C molecules on the invading placental trophoblast cells. The maternal KIR genes and their fetal ligands are highly variable, so different KIR/HLA-C genetic combinations occur in each pregnancy. Some women only possess inhibitory KIR genes, whereas other women also express activating KIR genes...
December 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27736914/induced-human-decidual-nk-like-cells-improve-utero-placental-perfusion-in-mice
#13
Ricardo C Cavalli, Ana Sofia Cerdeira, Elizabeth Pernicone, Henri A Korkes, Suzanne D Burke, Augustine Rajakumar, Ravi I Thadhani, Drucilla J Roberts, Manoj Bhasin, S Ananth Karumanchi, Hernan D Kopcow
Decidual NK (dNK) cells, a distinct type of NK cell, are thought to regulate uterine spiral artery remodeling, a process that allows for increased blood delivery to the fetal-placental unit. Impairment of uterine spiral artery remodeling is associated with decreased placental perfusion, increased uterine artery resistance, and obstetric complications such as preeclampsia and intrauterine growth restriction. Ex vivo manipulation of human peripheral blood NK (pNK) cells by a combination of hypoxia, TGFß-1 and 5-aza-2'-deoxycytidine yields cells with phenotypic and in vitro functional similarities to dNK cells, called idNK cells...
2016: PloS One
https://www.readbyqxmd.com/read/27733586/role-of-tumor-necrosis-factor-%C3%AE-and-natural-killer-cells-in-uterine-artery-function-and-pregnancy-outcome-in-the-stroke-prone-spontaneously-hypertensive-rat
#14
Heather Yvonne Small, Ryszard Nosalski, Hannah Morgan, Elisabeth Beattie, Tomasz J Guzik, Delyth Graham, Christian Delles
Women with chronic hypertension are at increased risk of maternal and fetal morbidity and mortality. We have previously characterized the stroke-prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery function and adverse pregnancy outcome compared with the control Wistar-Kyoto. The activation of the immune system plays a role in hypertension and adverse pregnancy outcome. Therefore, we investigated the role of tumor necrosis factor-α in the SHRSP phenotype in an intervention study using etanercept (0...
November 2016: Hypertension
https://www.readbyqxmd.com/read/27733584/tumor-necrosis-factor-%C3%AE-uterine-natural-killer-cells-and-pregnancy
#15
Michaela Golic, Friedrich C Luft, Ralf Dechend
No abstract text is available yet for this article.
November 2016: Hypertension
https://www.readbyqxmd.com/read/27699222/maternal-obesity-drives-functional-alterations-in-uterine-nk-cells
#16
Sofie Perdu, Barbara Castellana, Yoona Kim, Kathy Chan, Lauren DeLuca, Alexander G Beristain
Over one-fifth of North American women of childbearing age are obese, putting these women at risk for a variety of detrimental chronic diseases. In addition, obesity increases the risk for developing major complications during pregnancy. The mechanisms by which obesity contributes to pregnancy complications and loss remain unknown. Increasing evidence indicates that obesity results in major changes to adipose tissue immune cell composition and function; whether or not obesity also affects immune function in the uterus has not been explored...
July 21, 2016: JCI Insight
https://www.readbyqxmd.com/read/27593347/uterine-natural-killer-cells-dysregulation-in-idiopathic-human-preterm-birth-a-pilot-study
#17
Mostafa Fouad Gomaa, Ihab Fouad Serag Eldeen, Laila Aly Farid, Mourad Mohey Eldeen El-Saeed, Ahmed Mohammed Abas, Nahla Mohammad Aawd
OBJECTIVE: To compare between uterine natural killer (uNK) cells in the placental samples of preterm birth and term labor. STUDY DESIGN: Two-arm case-control study. This study included 60 participants divided into two groups. The first group included 30 cases of idiopathic spontaneous preterm labor and the other group included 30 women who delivered by a spontaneous term vaginal delivery and with no history of previous preterm labor. RESULT(S): There were no CD16(-) CD56(bright) uNK cells in either groups; CD16(+) CD56(dim) uNK cells were present in only 1 case out of 30 term delivery placentae (3...
September 5, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27550919/natural-killer-cell-reduction-and-uteroplacental-vasculopathy
#18
Michaela Golic, Nadine Haase, Florian Herse, Anika Wehner, Lisbeth Vercruysse, Robert Pijnenborg, Andras Balogh, Per Christian Saether, Erik Dissen, Friedrich C Luft, Lukasz Przybyl, Joon-Keun Park, Patji Alnaes-Katjavivi, Anne Cathrine Staff, Stefan Verlohren, Wolfgang Henrich, Dominik N Muller, Ralf Dechend
Uterine natural killer cells are important for uteroplacental development and pregnancy maintenance. Their role in pregnancy disorders, such as preeclampsia, is unknown. We reduced the number of natural killer cells by administering rabbit anti-asialo GM1 antiserum in an established rat preeclamptic model (female human angiotensinogen×male human renin) and evaluated the effects at the end of pregnancy (day 21), compared with preeclamptic control rats receiving normal rabbit serum. In 100% of the antiserum-treated, preeclamptic rats (7/7), we observed highly degenerated vessel cross sections in the mesometrial triangle at the end of pregnancy...
October 2016: Hypertension
https://www.readbyqxmd.com/read/27508757/-op-5d-01-inhibiton-of-tnf-alpha-signalling-using-etanercept-improves-deficient-uterine-artery-remodelling-and-pregnancy-outcome-in-the-stroke-prone-spontaneously-hypertensive-rat
#19
H Small, R Nosalski, H Morgan, E Beattie, T Guzik, D Graham, C Delles
OBJECTIVE: Impaired vascular remodelling has been extensively studied in pre-eclampsia but little is known about adaptation of the cardiovascular (CV) system to pregnancy in women with chronic hypertension. We have previously characterised the stroke prone spontaneously hypertensive rat (SHRSP) as a model of deficient uterine artery remodelling and identified an increase in pro-inflammatory TNF α relative to the normotensive WKY strain during pregnancy. DESIGN AND METHOD: SHRSP were treated with etanercept (0...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27452436/cox-2-plays-a-role-in-angiogenic-dba-unk-cell-subsets-activation-and-pregnancy-protection-in-lps-exposed-mice
#20
Bruno Zavan, Eliana Martins De Almeida, Évila da Silva Lopes Salles, Andréa Mollica do Amarante-Paffaro, Valdemar Antonio Paffaro
INTRODUCTION: Although uterine Natural Killer (uNK) cells have cytoplasmic granules rich in perforin and granzymes, these cells do not degranulate in normal pregnancy. DBA lectin(+) uNK cells produce angiogenic factors which stimulate remodeling of uterine arterioles to increase blood flow within the growing feto-placental unit. We sought to investigate the importance of COX-2 on mouse pregnancy inoculated with Gram-negative bacteria Lipopolysaccharide (LPS) by treating with a selective COX-2 inhibitor (nimesulide)...
August 2016: Placenta
keyword
keyword
46652
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"