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https://www.readbyqxmd.com/read/29768178/trained-memory-of-human-uterine-nk-cells-enhances-their-function-in-subsequent-pregnancies
#1
Moriya Gamliel, Debra Goldman-Wohl, Batya Isaacson, Chamutal Gur, Natan Stein, Rachel Yamin, Michael Berger, Myriam Grunewald, Eli Keshet, Yoach Rais, Chamutal Bornstein, Eyal David, Adam Jelinski, Iris Eisenberg, Caryn Greenfield, Arbel Ben-David, Tal Imbar, Ronit Gilad, Ronit Haimov-Kochman, David Mankuta, Matan Elami-Suzin, Ido Amit, Jacob H Hanna, Simcha Yagel, Ofer Mandelboim
Natural killer cells (NKs) are abundant in the human decidua, regulating trophoblast invasion and angiogenesis. Several diseases of poor placental development are associated with first pregnancies, so we thus looked to characterize differences in decidual NKs (dNKs) in first versus repeated pregnancies. We discovered a population found in repeated pregnancies, which has a unique transcriptome and epigenetic signature, and is characterized by high expression of the receptors NKG2C and LILRB1. We named these cells Pregnancy Trained decidual NK cells (PTdNKs)...
May 15, 2018: Immunity
https://www.readbyqxmd.com/read/29748088/innate-immune-cells-in-the-placental-bed-in-healthy-pregnancy-and-preeclampsia
#2
Marijke M Faas, Paul De Vos
Immune cells in the placental bed are important for adequate development of the placental bed. The most prominent immune cells in the placental bed early in pregnancy are uterine natural killer cells (uNK) cells and macrophages. Also dendritic cells and mast cells can be found in the early placental bed. These cells not only have an immune regulatory function, but are also involved in the regulation of trophoblast invasion, angiogenesis and spiral artery remodeling. In preeclampsia, one of the major complications of pregnancy, decreased trophoblast invasion and spiral artery remodeling has been found...
April 25, 2018: Placenta
https://www.readbyqxmd.com/read/29718698/placental-ischemia-stimulated-t-helper-17-cells-induce-preeclampsia-associated-cytolytic-natural-killer-cells-during-pregnancy
#3
Corbin A Shields, Maggie McCalmon, Tarek Ibrahim, Dakota L White, Jan Michael Williams, Babbette D LaMarca, Denise C Cornelius
Previous studies have demonstrated that T-helper 17 cells (TH 17s) and cytolytic NK cells (cNKs) are increased in women with preeclampsia (PE). In this study, we investigated the role of placental ischemia-stimulated TH 17s to induce cNKs in pregnancy. We further assessed the role of TH 17-mediated oxidative stress to facilitate cNK activation in pregnancy by treating with the SOD mimetic tempol. CD4+ /CD25- cells were isolated from reduced uterine perfusion pressure (RUPP) rats and differentiated into TH 17 cells in vitro...
May 2, 2018: American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
https://www.readbyqxmd.com/read/29572543/the-role-of-natural-killer-cells-in-the-uterine-microenvironment-during-pregnancy
#4
Julia P Andreotti, Ana E Paiva, Pedro H D M Prazeres, Daniel A P Guerra, Walison N Silva, Rogerio S Vaz, Akiva Mintz, Alexander Birbrair
No abstract text is available yet for this article.
March 23, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29569748/maternal-obesity-alters-uterine-nk-activity-through-a-functional-kir2dl1-s1-imbalance
#5
Barbara Castellana, Sofie Perdu, Yoona Kim, Kathy Chan, Jawairia Atif, Megan Marziali, Alexander G Beristain
In pregnancy, uterine natural killer cells (uNK) play essential roles in coordinating uterine angiogenesis, blood vessel remodeling, and promoting maternal tolerance to fetal tissue. Deviances from a normal uterine microenvironment are thought to modify uNK function(s) by limiting their ability to establish a healthy pregnancy. While maternal obesity has become a major health concern due to associations with adverse effects on fetal and maternal health, our understanding into how obesity contributes to poor pregnancy disorders is unknown...
March 23, 2018: Immunology and Cell Biology
https://www.readbyqxmd.com/read/29555668/at1-aa-angiotensin-ii-type-1-receptor-agonistic-autoantibody-blockade-prevents-preeclamptic-symptoms-in-placental-ischemic-rats
#6
Mark W Cunningham, Javier Castillo, Tarek Ibrahim, Denise C Cornelius, Nathan Campbell, Lorena Amaral, Venkata Ramana Vaka, Nathan Usry, Jan M Williams, Babbette LaMarca
Women with preeclampsia produce AT1-AA (agonistic autoantibodies to the angiotensin II type 1 receptor), which stimulate reactive oxygen species, inflammatory factors, and hypertensive mechanisms (ET [endothelin] and sFlt-1 [soluble fms-like tyrosine kinase-1]) in rodent models of preeclampsia. The placental ischemic reduced uterine perfusion pressure (RUPP) rat model of preeclampsia exhibits many of these features. In this study, we examined the maternal outcomes of AT1-AA inhibition ('n7AAc') in RUPP rats...
March 19, 2018: Hypertension
https://www.readbyqxmd.com/read/29485737/hypertension-in-pregnancy-taking-cues-from-pathophysiology-for-clinical-practice
#7
REVIEW
Ruxandra I Sava, Keith L March, Carl J Pepine
Pregnancy-related hypertension (PHTN) syndromes are a frequent and potentially deadly complication of pregnancy, while also negatively impacting the lifelong health of the mother and child. PHTN appears in women likely to develop hypertension later in life, with the stress of pregnancy unmasking a subclinical hypertensive phenotype. However, distinguishing between PHTN and chronic hypertension is essential for optimal management. Preeclampsia (PE) is linked to potentially severe outcomes and lacks effective treatments due to poorly understood mechanisms...
February 2018: Clinical Cardiology
https://www.readbyqxmd.com/read/29396049/increased-expression-of-angiogenic-cytokines-in-cd56-uterine-natural-killer-cells-from-women-with-recurrent-miscarriage
#8
Xiaoyan Chen, Yingyu Liu, Wing Ching Cheung, Yiwei Zhao, Jin Huang, Jacqueline Pui Wah Chung, Chi Chiu Wang, Tin Chiu Li
OBJECTIVE: To compare the expression pattern of angiogenic cytokines in CD56+ uNK cells from peri-implantation endometrium in women with a history of recurrent miscarriage and fertile controls. METHODS: 28 women were recruited, from which 18 women were diagnosed as recurrent miscarriage and 10 women were of proven fertility. Endometrial biopsy samples were obtained precisely 7 days after luteinization hormone surge in a natural cycle. The angiogenic profile of isolated CD56+ uNK cells was determined by RayBio human angiogenesis antibody array G Series 1000...
January 30, 2018: Cytokine
https://www.readbyqxmd.com/read/29394132/decrease-in-invasion-of-htr-8-svneo-trophoblastic-cells-by-interferon-gamma-involves-cross-communication-of-stat1-and-batf2-that-regulates-the-expression-of-jun
#9
Sonam Verma, Rahul Pal, Satish Kumar Gupta
Trophoblast invasion is one of the critical steps during embryo implantation. IFNG secreted during pregnancy by uterine NK cells acts as a negative regulator of invasion. IFNG in a dose dependent fashion inhibits invasion of HTR-8/SVneo trophoblastic cells. It phosphorylates STAT1 both at tyr 701 and ser 727 residues. Silencing of STAT1 significantly increases invasion (∼59%) of the cells. Based on NGS data, out of 207 genes, BATF2 expression was significantly increased after IFNG treatment. Silencing of BATF2 significantly increases the invasion of cells with (∼53%) or without (∼44%) treatment with IFNG...
February 20, 2018: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/29387191/maternal-natural-killer-cell-immunoglobulin-receptor-genes-and-human-leukocyte-antigen-c-ligands-influence-recurrent-spontaneous-abortion-in-the-han-chinese-population
#10
Ning Su, Hongdan Wang, Bowei Zhang, Yiqing Kang, Qiannan Guo, Hai Xiao, Hecai Yang, Shixiu Liao
The underlying mechanism of recurrent spontaneous abortion (RSA) has remained elusive for many years. Several previous studies have suggested that the killer cell immunoglobulin receptor (KIR) gene family is associated with RSA, however, it is not clear exactly how. The present study detected KIR and human leukocyte antigen-C (HLA-C) genes in 110 Han Chinese women with unexplained RSA and 105 Han Chinese healthy females. The aim of the present study was to determine if certain genotypes were more susceptible to the occurrence of miscarriage...
January 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29380456/uterine-natural-killer-cell-progenitor-populations-predict-successful-implantation-in-women-with-endometriosis-associated-infertility
#11
Louise E Glover, David Crosby, Uma Thiruchelvam, Cathal Harmon, Cáit Ni Chorcora, Mary B Wingfield, Cliona O'Farrelly
PROBLEM: Uterine natural killer (uNK) cells play a critical role early in gestation. As we previously identified altered uNK cell development in endometriosis-associated infertility, we herein sought to characterize natural killer (NK) cell profiles in endometriosis that may predict embryo implantation. METHOD OF STUDY: Study participants had a surgical diagnosis of endometriosis-associated infertility. Endometrial tissue and peripheral blood were obtained from 58 women...
March 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29262349/natural-killer-cells-promote-fetal-development-through-the-secretion-of-growth-promoting-factors
#12
Binqing Fu, Yonggang Zhou, Xiang Ni, Xianhong Tong, Xiuxiu Xu, Zhongjun Dong, Rui Sun, Zhigang Tian, Haiming Wei
Natural killer (NK) cells are present in large populations at the maternal-fetal interface during early pregnancy. However, the role of NK cells in fetal growth is unclear. Here, we have identified a CD49a+ Eomes+ subset of NK cells that secreted growth-promoting factors (GPFs), including pleiotrophin and osteoglycin, in both humans and mice. The crosstalk between HLA-G and ILT2 served as a stimulus for GPF-secreting function of this NK cell subset. Decreases in this GPF-secreting NK cell subset impaired fetal development, resulting in fetal growth restriction...
December 19, 2017: Immunity
https://www.readbyqxmd.com/read/29227245/clearance-of-senescent-decidual-cells-by-uterine-natural-killer-cells-in-cycling-human-endometrium
#13
Paul J Brighton, Yojiro Maruyama, Katherine Fishwick, Pavle Vrljicak, Shreeya Tewary, Risa Fujihara, Joanne Muter, Emma S Lucas, Taihei Yamada, Laura Woods, Raffaella Lucciola, Yie Hou Lee, Satoru Takeda, Sascha Ott, Myriam Hemberger, Siobhan Quenby, Jan Joris Brosens
In cycling human endometrium, menstruation is followed by rapid estrogen-dependent growth. Upon ovulation, progesterone and rising cellular cAMP levels activate the transcription factor Forkhead box O1 (FOXO1) in endometrial stromal cells (EnSCs), leading to cell cycle exit and differentiation into decidual cells that control embryo implantation. Here we show that FOXO1 also causes acute senescence of a subpopulation of decidualizing EnSCs in an IL-8 dependent manner. Selective depletion or enrichment of this subpopulation revealed that decidual senescence drives the transient inflammatory response associated with endometrial receptivity...
December 11, 2017: ELife
https://www.readbyqxmd.com/read/29195127/rapamycin-synergizes-with-cisplatin-in-antiendometrial-cancer-activation-by-improving-il-27-stimulated-cytotoxicity-of-nk-cells
#14
Wen-Jie Zhou, Kai-Kai Chang, Ke Wu, Hui-Li Yang, Jie Mei, Feng Xie, Da-Jin Li, Ming-Qing Li
Natural killer (NK) cell function is critical for controlling initial tumor growth and determining chemosensitivity of the tumor. A synergistic relationship between rapamycin and cisplatin in uterine endometrial cancer (UEC) in vitro has been reported, but the mechanism and the combined therapeutic strategy for endometrial cancer (EC) are still unknown. We found a positive correlation between the level of IL-27 and the differentiated stage of UEC. The increase of IL-27 in uterine endometrial cancer cell (UECC) lines (Ishikawa, RL95-2 and KLE) led to a high cytotoxic activity of NK cells to UECC in the co-culture system...
January 2018: Neoplasia: An International Journal for Oncology Research
https://www.readbyqxmd.com/read/29080885/roles-of-mifepristone-on-the-regulation-of-cytotoxic-lymphocytes-and-regulatory-t-cells
#15
Linxiang Liu, Feng Zhou, Jiale Qin, Zhida Qian, Lili Huang
OBJECTIVE: To investigate the immunologic function of mifepristone, which acts as a contraceptive drug at the level of the decidua. SETTING: In our hospital, 60 women (less than 63 days of amenorrhea) volunteered to terminate their pregnancies by the uterine suction evacuation method. Immunohistochemically, the transcription factor forkhead box P3 and granzyme B staining were performed to identify regulatory T cells and cytotoxic lymphocytes (CLs) in all operational subjects...
2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29056235/maternal-effector-t-cells-within-decidua-the-adaptive-immune-response-to-pregnancy
#16
D Lissauer, M D Kilby, P Moss
In human pregnancy the maternal immune system plays a critical role in the regulation of many aspects of human reproduction including implantation, placentation and defence against infection. Interest has been focussed on the role of uterine natural killer cells (uNK) in the maternal decidua whereas effector CD4+ and CD8+ T cells have received much less attention despite the observation that they represent a major proportion of decidual leucocytes in the latter phase of pregnancy. A range of recent studies have demonstrated that human decidual T cells are highly differentiated, express a range of cytokines and cytotoxic markers, and demonstrate a unique transcriptional profile characterized by high level expression of genes involved in interferon-signalling...
December 2017: Placenta
https://www.readbyqxmd.com/read/29043703/the-effects-of-dienogest-on-macrophage-and-natural-killer-cells-in-adenomyosis-a-randomized-controlled-study
#17
Saowapak Prathoomthong, Yada Tingthanatikul, Srithean Lertvikool, Nittaya Rodratn, Wanwisa Waiyaput, Kanthanadon Dittharot, Morakot Sroyraya, Areepan Sophonsritsuk
Background: Progestin has been used for symptomatic treatment of adenomyosis, although its effect on the immune system has not been studied. The aim of this study was to investigate the changes of macrophage and natural killer (NK) cell infiltration in tissues obtained from women with adenomyosis who did or did not receive oral progestin dienogest. MATERIALS AND METHODS: In this randomized controlled clinical trial study, 24 patients with adenomyosis who required hysterectomy were enrolled...
January 2018: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/29042488/natural-killer-cells-mediate-pathophysiology-in-response-to-reduced-uterine-perfusion-pressure
#18
Jamil Elfarra, Lorena M Amaral, Maggie McCalmon, Jeremy D Scott, Mark W Cunningham, Ashley Gnam, Tarek Ibrahim, Babbette LaMarca, Denise C Cornelius
Preeclampsia is associated with hypertension, small-for-gestational-age babies, and increased cytolytic natural killer (NK) cells. The specific role of cytolytic NK cells in the pathophysiology of preeclampsia has not been clearly defined. We hypothesized that <u>R</u>educed <u>U</u>terine <u>P</u>erfusion <u>P</u>ressure (RUPP) stimulates proliferation and cytolytic activation of NK cells, and that reducing NK cells in RUPP would prevent hypertension, intrauterine growth restriction, and inflammation in response to placental ischemia...
December 1, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28985196/inflammatory-stroma-of-lymphoepithelioma-like-carcinoma-of-the-cervix-immunohistochemical-study-of-3-cases-and-review-of-the-literature
#19
Amandine Philippe, Marc Rassy, Ligia Craciun, Céline Naveaux, Karen Willard-Gallo, Denis Larsimont, Isabelle Veys
The aim of this study was to characterize the inflammatory infiltrate of the lymphoepithelioma-like carcinoma, a variant of squamous cell carcinoma clinically associated with a good prognosis. Immunohistochemistry was used to characterize 3 cases of lymphoepithelioma-like carcinoma in the uterine cervix, diagnosed over a period of 3 yr. The patients were between 30 and 50 yr old. Their cervical smears had shown atypical squamous cells of unknown significance or high-grade squamous intraepithelial lesions, and the initial cervical biopsy showed high-grade cervical intraepithelial neoplasia (CIN3) or squamous cell carcinoma...
August 1, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/28935491/measurement-of-uterine-natural-killer-cell-percentage-in-the-periimplantation-endometrium-from-fertile-women-and-women-with-recurrent-reproductive-failure-establishment-of-a-reference-range
#20
Xiaoyan Chen, Najat Mariee, Lingming Jiang, Yingyu Liu, Chi Chiu Wang, Tin Chiu Li, Susan Laird
BACKGROUND: Uterine natural killer cells are the major leukocytes present in the periimplantation endometrium. Previous studies have found controversial differences in uterine natural killer cell percentage in women with recurrent reproductive failure compared with fertile controls. OBJECTIVE: We sought to compare the uterine natural killer cell percentage in women with recurrent reproductive failure and fertile controls. STUDY DESIGN: This was a retrospective study carried out in university hospitals...
December 2017: American Journal of Obstetrics and Gynecology
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