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decidual nk cells

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https://www.readbyqxmd.com/read/28794456/activated-nk-cells-cause-placental-dysfunction-and-miscarriages-in-fetal-alloimmune-thrombocytopenia
#1
Issaka Yougbaré, Wei-She Tai, Darko Zdravic, Brigitta Elaine Oswald, Sean Lang, Guangheng Zhu, Howard Leong-Poi, Dawei Qu, Lisa Yu, Caroline Dunk, Jianhong Zhang, John G Sled, Stephen J Lye, Jelena Brkić, Chun Peng, Petter Höglund, B Anne Croy, S Lee Adamson, Xiao-Yan Wen, Duncan J Stewart, John Freedman, Heyu Ni
Miscarriage and intrauterine growth restriction (IUGR) are devastating complications in fetal/neonatal alloimmune thrombocytopenia (FNAIT). We previously reported the mechanisms for bleeding diatheses, but it is unknown whether placental, decidual immune cells or other abnormalities at the maternal-fetal interface contribute to FNAIT. Here we show that maternal immune responses to fetal platelet antigens cause miscarriage and IUGR that are associated with vascular and immune pathologies in murine FNAIT models...
August 9, 2017: Nature Communications
https://www.readbyqxmd.com/read/28781765/up-and-down-immunity-of-pregnancy-in-humans
#2
REVIEW
Philippe Le Bouteiller, Armand Bensussan
One part of the human placenta in early pregnancy is particularly important for local immunity: the decidua basalis, which is transformed endometrium located at the site of embryo implantation . This placental bed tissue contains both maternal uterine immune cells, including decidual natural killer (NK) cells, the dominant leukocyte population exhibiting a unique phenotype, and fetal extravillous trophoblast which comes into direct contact with maternal decidual cells . To establish a successful placental development and healthy pregnancy outcome, the maternal immune system must tolerate paternal antigens expressed by trophoblast cells yet remain efficient for clearing any local pathogen infection...
2017: F1000Research
https://www.readbyqxmd.com/read/28702027/decreased-human-leukocyte-antigen-g-expression-by-mir-133a-contributes-to-impairment-of-proinvasion-and-proangiogenesis-functions-of-decidual-nk-cells
#3
Wenwei Guo, Liang Fang, Bo Li, Xifeng Xiao, Shuqiang Chen, Jun Wang, Fang Yang, Lihua Chen, Xiaohong Wang
Human leukocyte antigen (HLA)-G plays a crucial role in conferring fetal-maternal tolerance and ensuring a successful pregnancy. CD56(bright) natural killer (NK) cells accumulate at the maternal decidua in large numbers during pregnancy and are found in direct contact with fetal trophoblasts. There are increasing evidences that decidual NK (dNK) cells are crucial for pregnancy. However, the regulation of dNK cells is mostly unknown. Here, we provide evidences that the secretion function of dNK cells in recurrent spontaneous abortion was impaired, which led to the impairment of the proinvasion and proangiogenesis functions of dNK cells...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28693893/emerging-role-for-dysregulated-decidualization-in-the-genesis-of-preeclampsia
#4
Kirk P Conrad, Maria Belen Rabaglino, Emiel D Post Uiterweer
In normal human placentation, uterine invasion by trophoblast cells and subsequent spiral artery remodeling depend on cooperation among fetal trophoblasts and maternal decidual, myometrial, immune and vascular cells in the uterine wall. Therefore, aberrant function of anyone or several of these cell-types could theoretically impair placentation leading to the development of preeclampsia. Because trophoblast invasion and spiral artery remodeling occur during the first half of pregnancy, the molecular pathology of fetal placental and maternal decidual tissues following delivery may not be informative about the genesis of impaired placentation, which transpired months earlier...
June 9, 2017: Placenta
https://www.readbyqxmd.com/read/28677766/human-decidua-mesenchymal-stem-cells-regulate-decidual-natural-killer-cell-function-via-interactions-between-collagen-and-leukocyte%C3%A2-associated-immunoglobulin%C3%A2-like-receptor-1
#5
Qiang Fu, Xuejing Man, Min Yu, Yongli Chu, Xiying Luan, Hailan Piao, Jiangnan Xue, Changzhu Jin
The development of maternal tolerance to the fetal allograft in critical for the maintenance of the pregnancy, and it is accompanied by the development of a special decidual natural killer (dNK) cell tolerance phenotype. To understand the factors that influence dNK cells during early pregnancy, the present study aimed to identify mesenchymal stem cells (MSCs) from human first‑trimester deciduas, termed decidual MSCs (DMSCs), and to investigate the effect of DMSCs on the regulation of dNK cells via collagen...
September 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28653669/dnk-cells-facilitate-the-interaction-between-trophoblastic-and-endothelial-cells-via-vegf-c-and-hgf
#6
Liyang Ma, Guanlin Li, Guangming Cao, Yuchun Zhu, Mei-Rong Du, Yangyu Zhao, Hao Wang, Yanlei Liu, Yanyan Yang, Yu-Xia Li, Da-Jin Li, Huixia Yang, Yan-Ling Wang
Decidual NK (dNK) cells, identified as CD56(bright)CD16(-)CD3(-), account for ~70% of lymphocytes within the uterine wall during early pregnancy. Accumulating evidence suggests that tight interactions between placental trophoblasts and dNK cells are critical for trophoblast cell differentiation. However, the underlying mechanism remains to be explored in detail. In the present study, conditioned medium (CM) was collected from cultured primary human dNK cells. Primary cytotrophoblasts (CTBs) or the human trophoblast cell line HTR8/SVneo was treated with dNK-CM and co-cultured with human umbilical vein endothelial cells (HUVECs) in a three-dimensional Matrigel scaffold, and the formation of tube structures was dynamically monitored with live cell imaging...
September 2017: Immunology and Cell Biology
https://www.readbyqxmd.com/read/28588205/human-uterine-lymphocytes-acquire-a-more-experienced-and-tolerogenic-phenotype-during-pregnancy
#7
Dorien Feyaerts, Marilen Benner, Bram van Cranenbroek, Olivier W H van der Heijden, Irma Joosten, Renate G van der Molen
Pregnancy requires a delicate immune balance that nurtures the allogeneic fetus, while maintaining reactivity against pathogens. Despite increasing knowledge, data is lacking on the transition of pre-pregnancy endometrial lymphocytes to a pregnancy state. Here, we immunophenotyped lymphocytes from endometrium (MMC), term decidua parietalis (DPMC), and PBMC for direct comparison. We found that the immune cell composition of MMC and DPMC clearly differ from each other, with less NK-cells, and more NKT-cells and T-cells in DPMC...
June 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28566515/a-microfluidics-assay-to-study-invasion-of-human-placental-trophoblast-cells
#8
Yassen Abbas, Carolin Melati Oefner, William J Polacheck, Lucy Gardner, Lydia Farrell, Andrew Sharkey, Roger Kamm, Ashley Moffett, Michelle L Oyen
Pre-eclampsia, fetal growth restriction and stillbirth are major pregnancy disorders throughout the world. The underlying pathogenesis of these diseases is defective placentation characterized by inadequate invasion of extravillous placental trophoblast cells into the uterine arteries. How trophoblast invasion is controlled remains an unanswered question but is influenced by maternal uterine immune cells called decidual natural killer cells. Here, we describe an in vitro microfluidic invasion assay to study the migration of primary human trophoblast cells...
May 2017: Journal of the Royal Society, Interface
https://www.readbyqxmd.com/read/28507070/limited-colonization-undermined-by-inadequate-early-immune-responses-defines-the-dynamics-of-decidual-listeriosis
#9
Gabrielle Rizzuto, Elisa Tagliani, Priyanka Manandhar, Adrian Erlebacher, Anna I Bakardjiev
The bacterial pathogen Listeria monocytogenes causes foodborne systemic disease in pregnant women, which can lead to preterm labor, stillbirth, or severe neonatal disease. Colonization of the maternal decidua appears to be an initial step in the maternal component of the disease as well as bacterial transmission to the placenta and fetus. Host-pathogen interactions in the decidua during this early stage of infection remain poorly understood. Here, we assessed the dynamics of L. monocytogenes infection in primary human decidual organ cultures and in the murine decidua in vivo A high inoculum was necessary to infect both human and mouse deciduas, and the data support the existence of a barrier to initial colonization of the murine decidua...
August 2017: Infection and Immunity
https://www.readbyqxmd.com/read/28479751/uterine-cd56-dim-and-cd16-cells-in-refractory-antiphospholipid-antibody-related-pregnancy-loss-and-chromosomally-intact-abortuses-a-case-control-study
#10
Mostafa F Gomaa, Abdeiiatif G Elkhouly, Mohammad M Farghly, Laila A Farid, Nahla M Awad
AIM: To evaluate the role of uterine natural killer (uNK) CD56(dim) and CD16(+) cells in patients with refractory antiphospholipid, antibody-mediated, recurrent, pregnancy loss. SETTINGS AND DESIGN: A case-control study was conducted between 2012 and 2015 at a university hospital. PATIENTS AND METHODS: A group of 118 women with a history of antiphospholipid antibody syndrome experiencing fetal loss in spite of low dose aspirin (LDA) and low molecular weight heparin (LMWH) treatment in the current pregnancy were included in this study...
January 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28474619/number-of-decidual-natural-killer-cells-macrophages-in-pre-eclampsia
#11
Jelena Milosevic-Stevanovic, Miljan Krstic, Dragana Radovic-Janosevic, Jasmina Popovic, Marija Tasic, Slavica Stojnev
BACKGROUND & OBJECTIVES: The process of human placentation is complex and still not well understood. This study was aimed to examine the relationship between clinical features of pre-eclampsia and degree of trophoblastic invasion after its immunohistochemical visualization in the context of possible alterations in the number of natural killer (NK) cells and macrophages in the decidua. METHODS: This prospective study included a study group comprising 30 pregnant women with pre-eclampsia delivered by caesarean section and a control group comprising 20 healthy pregnant women also delivered by caesarean section...
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28474613/role-of-decidual-natural-killer-cells-macrophages-in-pre-eclampsia
#12
Pranab Dey
No abstract text is available yet for this article.
December 2016: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/28438315/tgf-%C3%AE-1-improving-abnormal-pregnancy-outcomes-induced-by-toxoplasma-gondii-infection-regulating-nkg2d-dap10-and-killer-subset-of-decidual-nk-cells
#13
Xiaoyan Xu, Jian Zhang, Shaowei Zhan, Zhidan Li, Xianbing Liu, Haixia Zhang, Yuzhu Jiang, Xuemei Hu
Our current aim was to investigate whether injection of TGF-β1 played an important role in improving abnormal pregnancy outcomes with T. gondii infection and how the TGF-β1 regulated. Results showed that TGF-β1 exhibited improved pregnancy outcomes induced by T. gondii infection. dNK cytotoxicity was increased with T. gondii infection while decreased with TGF-β1 treatment. dNK cytotoxicity related NKG2D/DAP10 expression, perforin, granzyme, IFN-γ and killer subsets were all increased with T. gondii infection while decreased after TGF-β1 treatment...
July 2017: Cellular Immunology
https://www.readbyqxmd.com/read/28434167/analysis-of-s1p-receptor-expression-by-uterine-immune-cells-using-standardized-multi-parametric-flow-cytometry
#14
Jianhong Zhang, Annie Bang, Stephen J Lye
Flow cytometry is a powerful tool for phenotypic and functional analyses of single immune cells. The increasing capability of flow cytometry technology has driven a more detailed understanding of immune cell subsets and functions in complex cellular systems such as the developing human decidua/placenta. We propose a standardized procedure for the isolation and analysis of human decidual natural killer (dNK) cells and this method can be extended to investigation of other uterine lymphocytes. Here this platform is used to examine the expression of sphingosine-1-phosphate (S1P) receptor and functional growth factors by dNK cells...
April 23, 2017: Methods in Molecular Biology
https://www.readbyqxmd.com/read/28429258/hormonal-regulation-of-nk-cell-cytotoxic-activity
#15
S V Shirshev, I V Nekrasova, O L Gorbunova, E G Orlova
The effects of chorionic gonadotropin, estriol (E3), leptin, ghrelin, and kisspeptin on the intracellular expression of perforin, granzyme A, and granzyme B was studied in separated NK cells. All studied hormones except E3 are could modulate the expression of cytotoxic enzymes in NK cells by suppression of the expression of the most active proapoptotic agents, resulting in increased expression of granzyme A, which is typical of the decidual subpopulation of these lymphocytes.
January 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28425436/corrigendum-mhc-dependent-inhibition-of-uterine-nk-cells-impedes-fetal-growth-and-decidual-vascular-remodeling
#16
Jens Kieckbusch, Louise M Gaynor, Ashley Moffett, Francesco Colucci
No abstract text is available yet for this article.
April 20, 2017: Nature Communications
https://www.readbyqxmd.com/read/28417191/mapping-of-estradiol-binding-sites-through-receptor-micro-autoradiography-in-the-endometrial-stroma-of-early-pregnant-mice
#17
Telma M T Zorn, Rodolfo R Favaro, Mauricio Soto-Suazo, Walter E Stumpf
Estradiol triggers key biological responses in the endometrium, which rely on the presence and levels of its cognate receptors on target cells. Employing the receptor micro-autoradiography (RMAR) technique, we aimed to provide a temporal and spatial map of the functional binding sites for estradiol in the mouse endometrial stroma during early pregnancy. Uterine samples from days 1.5 to 7.5 of pregnancy were collected 1 h after tritiated- (3H-) estradiol administration and prepared for RMAR analysis. Autoradiographic incorporation of 3H-thymidine (after 1-h pulse) was evaluated over the same gestational interval...
September 2017: Histochemistry and Cell Biology
https://www.readbyqxmd.com/read/28402512/defective-trophoblast-invasion-underlies-fetal-growth-restriction-and-preeclampsia-like-symptoms-in-the-stroke-prone-spontaneously-hypertensive-rat
#18
G Barrientos, M Pussetto, M Rose, A C Staff, S M Blois, J E Toblli
STUDY QUESTION: What is the impact of chronic hypertension on placental development, fetal growth and maternal outcome in the stroke-prone spontaneously hypertensive rat (SHRSP)? SUMMARY ANSWER: SHRSP showed an impaired remodeling of the spiral arteries and abnormal pattern of trophoblast invasion during placentation, which were associated with subsequent maternal glomerular injury and increased baseline hypertension as well as placental insufficiency and asymmetric fetal growth restriction (FGR)...
July 1, 2017: Molecular Human Reproduction
https://www.readbyqxmd.com/read/28396316/extravillous-trophoblast-and-endothelial-cell-crosstalk-mediates-leukocyte-infiltration-to-the-early-remodeling-decidual-spiral-arteriole-wall
#19
Ruhul H Choudhury, Caroline E Dunk, Stephen J Lye, John D Aplin, Lynda K Harris, Rebecca L Jones
Decidual spiral arteriole (SpA) remodeling is essential to ensure optimal uteroplacental blood flow during human pregnancy, yet very little is known about the regulatory mechanisms. Uterine decidual NK (dNK) cells and macrophages infiltrate the SpAs and are proposed to initiate remodeling before colonization by extravillous trophoblasts (EVTs); however, the trigger for their infiltration is unknown. Using human first trimester placenta, decidua, primary dNK cells, and macrophages, we tested the hypothesis that EVTs activate SpA endothelial cells to secrete chemokines that have the potential to recruit maternal immune cells into SpAs...
May 15, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28369855/in-vivo-activation-of-invariant-natural-killer-t-cells-induces-systemic-and-local-alterations-in-t-cell-subsets-prior-to-preterm-birth
#20
N Gomez-Lopez, R Romero, M Arenas-Hernandez, G Schwenkel, D St Louis, S S Hassan, T N Mial
Preterm birth, the leading cause of neonatal morbidity and mortality worldwide, is frequently preceded by spontaneous preterm labour, a syndrome of multiple aetiologies. Pathological inflammation is causally linked to spontaneous preterm labour. Indeed, direct activation of invariant natural killer T (iNKT) cells via α-galactosylceramide induces preterm labour/birth largely by initiating systemic and local (i.e. decidua and myometrium) innate immune responses. Herein, we investigated whether iNKT-cell activation altered local and systemic T-cell subsets...
August 2017: Clinical and Experimental Immunology
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