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HMGB1 and pyroptosis

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https://www.readbyqxmd.com/read/27812336/piperine-suppresses-pyroptosis-and-interleukin-1%C3%AE-release-upon-atp-triggering-and-bacterial-infection
#1
Yi-Dan Liang, Wen-Jing Bai, Chen-Guang Li, Li-Hui Xu, Hong-Xia Wei, Hao Pan, Xian-Hui He, Dong-Yun Ouyang
Piperine is a phytochemical present in black pepper (Piper nigrum Linn) and other related herbs, possessing a wide array of pharmacological activities including anti-inflammatory effects. Previously, we demonstrated that piperine has therapeutic effects on bacterial sepsis in mice, but the underlying mechanism has not been fully elucidated. In this study, we aimed to investigate the influences of piperine on pyroptosis in murine macrophages. The results showed that piperine dose-dependently inhibited ATP-induced pyroptosis, thereby suppressing interleukin-1β (IL-1β) or high mobility group box-1 protein (HMGB1) release in LPS-primed bone marrow-derived macrophages and J774A...
2016: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/27798227/cell-death-mechanisms-in-human-chronic-liver-diseases-a-far-cry-from-clinical-applicability
#2
REVIEW
Guillermo Mazzolini, Jan-Peter Sowa, Ali Canbay
The liver is constantly exposed to a host of injurious stimuli. This results in hepatocellular death mainly by apoptosis and necrosis, but also due to autophagy, necroptosis, pyroptosis and in some cases by an intricately balanced combination thereof. Overwhelming and continuous cell death in the liver leads to inflammation, fibrosis, cirrhosis, and eventually hepatocellular carcinoma. Although data from various disease models may suggest a specific (predominant) cell death mode for different aetiologies, the clinical reality is not as clear cut...
December 1, 2016: Clinical Science (1979-)
https://www.readbyqxmd.com/read/27607578/hemorrhagic-shock-primes-for-lung-vascular-endothelial-cell-pyroptosis-role-in-pulmonary-inflammation-following-lps
#3
Jie Yang, Yanfeng Zhao, Peng Zhang, Yuehua Li, Yong Yang, Yang Yang, Junjie Zhu, Xiao Song, Gening Jiang, Jie Fan
Hemorrhagic shock (HS) often renders patients more susceptible to lung injury by priming for an exaggerated response to a second infectious stimulus. Acute lung injury (ALI) is a major component of multiple organ dysfunction syndrome following HS and regularly serves as a major cause of patient mortality. The lung vascular endothelium is an active organ that has a central role in the development of ALI through synthesizing and releasing of a number of inflammatory mediators. Cell pyroptosis is a caspase-1-dependent regulated cell death, which features rapid plasma membrane rupture and release of proinflammatory intracellular contents...
September 8, 2016: Cell Death & Disease
https://www.readbyqxmd.com/read/26987291/immunogenic-cell-death-by-oncolytic-herpes-simplex-virus-type-1-in-squamous-cell-carcinoma-cells
#4
A Takasu, A Masui, M Hamada, T Imai, S Iwai, Y Yura
Molecules essential for the induction of immunogenic cell death (ICD) are called damage-associated molecular patterns (DAMPs). The effects of oncolytic herpes simplex virus type 1 (HSV-1) on the production of DAMPs were examined in squamous cell carcinoma (SCC) cells. The cytopathic effects of HSV-1 RH2 were observed in mouse SCCVII cells infected at a high multiplicity of infection (MOI), and the amounts of viable cells were decreased. After being infected with RH2, ATP and high mobility group box 1 (HMGB1) were released extracellulary, while calreticulin (CRT) translocated to the cell membrane...
April 2016: Cancer Gene Therapy
https://www.readbyqxmd.com/read/26939040/interferon-regulatory-factor-1-mediates-alveolar-macrophage-pyroptosis-during-lps-induced-acute-lung-injury-in-mice
#5
Dongdong Wu, Pinhua Pan, Xiaoli Su, Lemeng Zhang, Qingwu Qin, Hongyi Tan, Li Huang, Yuanyuan Li
Previously, we demonstrated that pyroptosis in alveolar macrophages (AMs) plays an essential role in lipopolysaccharide (LPS)-induced acute lung injury. However, the underlying mechanism remains largely unclear. Here, we show that the absence of interferon regulatory factor 1 (IRF-1) in genetic knock-out mice strongly abrogates pyroptosis in AMs and alleviates the LPS-induced lung injury and systemic inflammation. Our study demonstrates that IRF-1 contributes to caspase-1 activation and apoptosis-associated speck-like protein containing a caspase activation and recruitment domain pyroptosome formation in AMs and leads to downstream inflammatory cytokine release, including that of IL-1β, IL-18, and HMGB1...
September 2016: Shock
https://www.readbyqxmd.com/read/26765310/gossypol-induces-pyroptosis-in-mouse-macrophages-via-a-non-canonical-inflammasome-pathway
#6
Qiu-Ru Lin, Chen-Guang Li, Qing-Bing Zha, Li-Hui Xu, Hao Pan, Gao-Xiang Zhao, Dong-Yun Ouyang, Xian-Hui He
Gossypol, a polyphenolic compound isolated from cottonseeds, has been reported to possess many pharmacological activities, but whether it can influence inflammasome activation remains unclear. In this study, we found that in mouse macrophages, gossypol induced cell death characterized by rapid membrane rupture and robust release of HMGB1 and pro-caspase-11 comparable to ATP treatment, suggesting an induction of pyroptotic cell death. Unlike ATP, gossypol induced much low levels of mature interleukin-1β (IL-1β) secretion from mouse peritoneal macrophages primed with LPS, although it caused pro-IL-1β release similar to that of ATP...
February 1, 2016: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/26682763/beyond-the-grave-when-is-cell-death-critical-for-immunity-to-infection
#7
REVIEW
H N Stephenson, A Herzig, A Zychlinsky
Immune cell death is often observed in response to infection. There are three potential beneficial outcomes after host cell death: (1) the removal of an intracellular niche for microbes, (2) direct microbicidal activity of released components and (3) the propagation of an inflammatory response. Recent findings suggest that three forms of non-apoptotic regulated cell death, pyroptosis, necroptosis and NETosis, can impact on immunity to bacterial infection. However, it is challenging to design experiments that unequivocally prove the advantageous effects of regulated cell death on immunity...
February 2016: Current Opinion in Immunology
https://www.readbyqxmd.com/read/26605648/high-mobility-group-box-protein-1-hmgb1-the-prototypical-endogenous-danger-molecule
#8
REVIEW
Huan Yang, Haichao Wang, Sangeeta S Chavan, Ulf Andersson
High mobility group box protein 1 (HMGB1) is an evolutionary ancient nuclear protein that exerts divergent biological tasks inside and outside of cells. The functions of HMGB1 depend on location, binding partners and redox states of the molecule. In the nucleus, HMGB1 organizes DNA and nucleosomes and regulates gene transcription. Upon cell activation or injury, nuclear HMGB1 can translocate to the cytoplasm, where it is involved in inflammasome activation and pyroptosis, as well as regulation of the autophagy/apoptosis balance...
October 27, 2015: Molecular Medicine
https://www.readbyqxmd.com/read/26552848/modulation-of-p2x4-p2x7-pannexin-1-sensitivity-to-extracellular-atp-via-ivermectin-induces-a-non-apoptotic-and-inflammatory-form-of-cancer-cell-death
#9
Dobrin Draganov, Sailesh Gopalakrishna-Pillai, Yun-Ru Chen, Neta Zuckerman, Sara Moeller, Carrie Wang, David Ann, Peter P Lee
Overexpression of P2X7 receptors correlates with tumor growth and metastasis. Yet, release of ATP is associated with immunogenic cancer cell death as well as inflammatory responses caused by necrotic cell death at sites of trauma or ischemia-reperfusion injury. Using an FDA-approved anti-parasitic agent Ivermectin as a prototype agent to allosterically modulate P2X4 receptors, we can switch the balance between the dual pro-survival and cytotoxic functions of purinergic signaling in breast cancer cells. This is mediated through augmented opening of the P2X4/P2X7-gated Pannexin-1 channels that drives a mixed apoptotic and necrotic mode of cell death associated with activation of caspase-1 and is consistent with pyroptosis...
November 10, 2015: Scientific Reports
https://www.readbyqxmd.com/read/26415803/inhibition-of-alveolar-macrophage-pyroptosis-reduces-lipopolysaccharide-induced-acute-lung-injury-in-mice
#10
Dong-Dong Wu, Pin-Hua Pan, Ben Liu, Xiao-Li Su, Le-Meng Zhang, Hong-Yi Tan, Zu Cao, Zuo-Ren Zhou, Hai-Tao Li, Hao-Si Li, Li Huang, Yuan-Yuan Li
BACKGROUND: Pyroptosis is the term for caspase-1-dependent cell death associated with pro-inflammatory cytokines. The role of alveolar macrophage (AM) pyroptosis in the pathogenesis of the acute lung injury and acute respiratory distress syndrome (ALI/ARDS) remains unclear. METHODS: C57BL/6 wild-type mice were assigned to sham, lipopolysaccharide (LPS) + vehicle, LPS + acetyl-tyrosyl-valyl- alanyl-aspartyl-chloromethylketone (Ac-YVAD-CMK) and LPS + Z-Asp-Glu-Val-Asp-fluoromethylketone groups...
October 5, 2015: Chinese Medical Journal
https://www.readbyqxmd.com/read/26118732/the-role-of-cell-death-in-the-pathogenesis-of-sle-is-pyroptosis-the-missing-link
#11
REVIEW
M Magna, D S Pisetsky
Systemic lupus erythematosus (SLE) is a prototypic autoimmune disease characterized by the production of antinuclear antibodies (ANAs) in association with systemic inflammation and organ damage. In addition to genetic factors, a contribution of infection to disease induction has been proposed. In the pathogenesis of lupus, immune complexes of ANAs with nuclear antigens can form and both deposit in the tissue and stimulate cytokine production to intensify inflammation. As such, the extracellular release of nuclear antigens to form pathogenic immune complexes is an important step in the pathway to disease...
September 2015: Scandinavian Journal of Immunology
https://www.readbyqxmd.com/read/25931416/heatstroke-induces-liver-injury-via-il-1%C3%AE-and-hmgb1-induced-pyroptosis
#12
Yan Geng, Qiang Ma, Ya-Nan Liu, Na Peng, Fang-Fang Yuan, Xing-Gui Li, Ming Li, Ying-Song Wu, Bing-ling Li, Wei-bing Song, Wei Zhu, Wei-Wen Xu, Jie Fan, Lei Su
BACKGROUND & AIMS: Liver injury is a common complication of heat stroke (HS), and often constitutes a direct cause for patient death. The cellular and molecular mechanism underlying HS-induced liver injury remains unclear. Recent evidence indicates that inflammasome plays an important role in mediating sterile inflammation triggered by tissue damage. Using a rat HS model, we identified a novel mechanism by which inflammasome-dependent interleukin-1β (IL-1β) activation and hepatocyte pyroptosis mediate HS-induced liver injury...
September 2015: Journal of Hepatology
https://www.readbyqxmd.com/read/25904867/oxidative-stress-mediated-hmgb1-biology
#13
REVIEW
Yan Yu, Daolin Tang, Rui Kang
High mobility group box 1 (HMGB1) is a widely-expressed and highly-abundant protein that acts as an extracellular signal upon active secretion by immune cells or passive release by dead, dying, and injured cells. Both intracellular and extracellular HMGB1 play pivotal roles in regulation of the cellular response to stress. Targeting the translocation, release, and activity of HMGB1 can limit inflammation and reduce tissue damage during infection and sterile inflammation. Although the mechanisms contributing to HMGB1 biology are still under investigation, it appears that oxidative stress is a central regulator of HMGB1's translocation, release, and activity in inflammation and cell death (e...
2015: Frontiers in Physiology
https://www.readbyqxmd.com/read/25757059/autophagy-and-inflammasome-interplay
#14
REVIEW
João D Martins, Joana Liberal, Ana Silva, Isabel Ferreira, Bruno Miguel Neves, Maria Teresa Cruz
Inflammation is a defensive response of the organism to manage harmful stimuli sensed by innate immune cells. The signal alarm is triggered by the recognition of pathogen-associated molecular patterns, such as microbial components, or host-derived damage-associated molecular patterns (DAMPs), namely high-mobility group box 1 protein (HMGB1) and purine metabolites, through a set of highly conserved receptors in immune cells termed pattern recognition receptors. Among these receptors, membrane-associated toll-like receptors (TLRs) and cytosolic nucleotide binding and oligomerization domain (nod)-like receptors (NLRs) assume particular relevance in the inflammatory process...
April 2015: DNA and Cell Biology
https://www.readbyqxmd.com/read/24850431/caspase-11-is-expressed-in-the-colonic-mucosa-and-protects-against-dextran-sodium-sulfate-induced-colitis
#15
D Demon, A Kuchmiy, A Fossoul, Q Zhu, T-D Kanneganti, M Lamkanfi
Ulcerative colitis and Crohn's disease are major inflammatory syndromes that affect millions of patients. Caspase-11 confers protection against Gram-negative enteropathogens, but its role during colitis is unknown. Here, we show that caspase-11 was constitutively expressed in the colon, and that caspase-11-deficient (caspase-11(-/-)) mice were hypersusceptible to dextran sodium sulfate (DSS)-induced colitis. Notably, pro-inflammatory Prevotella species were strongly reduced in the gut microbiota of caspase-11(-/-) mice...
November 2014: Mucosal Immunology
https://www.readbyqxmd.com/read/24769733/macrophage-endocytosis-of-high-mobility-group-box-1-triggers-pyroptosis
#16
J Xu, Y Jiang, J Wang, X Shi, Q Liu, Z Liu, Y Li, M J Scott, G Xiao, S Li, L Fan, T R Billiar, M A Wilson, J Fan
Macrophages can be activated and regulated by high-mobility group box 1 (HMGB1), a highly conserved nuclear protein. Inflammatory functions of HMGB1 are mediated by binding to cell surface receptors, including the receptor for advanced glycation end products (RAGE), Toll-like receptor (TLR)2, TLR4, and TLR9. Pyroptosis is a caspase-1-dependent programmed cell death, which features rapid plasma membrane rupture, DNA fragmentation, and release of proinflammatory intracellular contents. Pyroptosis can be triggered by various stimuli, however, the mechanism underlying pyroptosis remains unclear...
August 2014: Cell Death and Differentiation
https://www.readbyqxmd.com/read/24531836/the-role-of-hmgb1-in-the-pathogenesis-of-inflammatory-and-autoimmune-diseases
#17
REVIEW
Melinda Magna, David S Pisetsky
High-mobility group box 1 (HMGB1) protein is a highly abundant protein that can promote the pathogenesis of inflammatory and autoimmune diseases once it is in an extracellular location. This translocation can occur with immune cell activation as well as cell death, with the conditions for release associated with the expression of different isoforms. These isoforms result from post-translational modifications, with the redox states of three cysteines at positions 23, 45 and 106 critical for activity. Depending on the redox states of these residues, HMGB1 can induce cytokine production via toll-like receptor 4 (TLR4) or promote chemotaxis by binding the chemokine CXCL12 for stimulation via CXCR4...
2014: Molecular Medicine
https://www.readbyqxmd.com/read/24492532/activation-of-the-nlrp1b-inflammasome-independently-of-asc-mediated-caspase-1-autoproteolysis-and-speck-formation
#18
Nina Van Opdenbosch, Prajwal Gurung, Lieselotte Vande Walle, Amelie Fossoul, Thirumala-Devi Kanneganti, Mohamed Lamkanfi
Despite its clinical importance in infection and autoimmunity, the activation mechanisms of the NLRP1b inflammasome remain enigmatic. Here we show that deletion of the inflammasome adaptor ASC in BALB/c mice and in C57BL/6 macrophages expressing a functional NLRP1b prevents anthrax lethal toxin (LeTx)-induced caspase-1 autoproteolysis and speck formation. However, ASC(-/-) macrophages undergo normal LeTx-induced pyroptosis and secrete significant amounts of interleukin (IL)-1β. In contrast, ASC is critical for caspase-1 autoproteolysis and IL-1β secretion by the NLRC4, NLRP3 and AIM2 inflammasomes...
2014: Nature Communications
https://www.readbyqxmd.com/read/24431405/curcumin-a-double-hit-on-malignant-mesothelioma
#19
Jill M Miller, Joyce K Thompson, Maximilian B MacPherson, Stacie L Beuschel, Catherine M Westbom, Mutlay Sayan, Arti Shukla
Inflammation is a key mediator in the development of malignant mesothelioma, which has a dismal prognosis and poor therapeutic strategies. Curcumin, a naturally occurring polyphenol in turmeric, has been shown to possess anticarcinogenic properties through its anti-inflammatory effects. Inflammasomes, a component of inflammation, control the activation of caspase-1 leading to pyroptosis and processing of proinflammatory cytokines, interleukin (IL)-1β and IL-18. In the present study, we investigate the role of curcumin in pyroptotic cell death of malignant mesothelioma cells...
March 2014: Cancer Prevention Research
https://www.readbyqxmd.com/read/24336085/induction-of-necrotic-cell-death-by-oxidative-stress-in-retinal-pigment-epithelial-cells
#20
J Hanus, H Zhang, Z Wang, Q Liu, Q Zhou, S Wang
Age-related macular degeneration (AMD) is a degenerative disease of the retina and the leading cause of blindness in the elderly. Retinal pigment epithelial (RPE) cell death and the resultant photoreceptor apoptosis are characteristic of late-stage dry AMD, especially geographic atrophy (GA). Although oxidative stress and inflammation have been associated with GA, the nature and underlying mechanism for RPE cell death remains controversial, which hinders the development of targeted therapy for dry AMD. The purpose of this study is to systematically dissect the mechanism of RPE cell death induced by oxidative stress...
December 12, 2013: Cell Death & Disease
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