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https://www.readbyqxmd.com/read/29223112/development-of-the-handwriting-legibility-scale-hls-a-preliminary-examination-of-reliability-and-validity
#1
Anna L Barnett, Mellissa Prunty, Sara Rosenblum
BACKGROUND: Demands for the production of legible handwriting produced in a timely manner increase as children progress through school. Despite the considerable number of children faced with handwriting difficulties, there is no quick and practical tool to assess legibility in this population. AIM: The aim of this study was to develop the Handwriting Legibility Scale (HLS) and to establish the scale's reliability and validity. METHODS: The HLS is a non-language dependent scale which assesses global legibility, based on five criteria applied to samples of 'free writing'...
December 6, 2017: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29222987/frequency-and-correlates-of-tardive-dyskinesia-in-indian-patients-with-type-i-bipolar-disorder
#2
Tess Maria Rajan, Balaji Bharadwaj, Ravi Philip Rajkumar, Prashant Shankarrao Adole
BACKGROUND: Patients with Bipolar Disorder (BD) may have higher risk of Tardive Dyskinesia (TD). Theories for TD include inflammatory or oxidative stress and altered iron metabolism. The current frequency and clinical and biochemical correlates of TD in BD needs exploration. OBJECTIVES: To assess: (1) the frequency of TD in BD; (2) clinical correlates of TD in BD; (3) oxidative stress markers, inflammatory markers and hepcidin in TD in BD. MATERIALS & METHODS: In this cross-sectional study, 170 patients with BD were assessed for clinical characteristics using structured assessments...
December 5, 2017: Asian Journal of Psychiatry
https://www.readbyqxmd.com/read/29222140/correction-to-td-19-an-erlotinib-derivative-induces-epidermal-growth-factor-receptor-wild-type-nonsmall-cell-lung-cancer-apoptosis-through-cip2a-mediated-pathway
#3
(no author information available yet)
No abstract text is available yet for this article.
January 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29218581/fabrication-of-tip-dissolving-microneedles-for-transdermal-drug-delivery-of-meloxicam
#4
Jianmin Chen, Weiyue Huang, Ziyao Huang, Shiqi Liu, Yaling Ye, Qinglian Li, Meiping Huang
Dissolving microneedles (MNs) offered a simple, minimally invasive method for meloxicam (MX) delivery to the skin. However, the fabrication of dissolving MNs still faced some challenges, such as significant time consumption, loss of drug activity, and difficulty in regulating MN drug loading. To address these issues, we developed the tip-dissolving (TD) MNs. Several kinds of drugs were encapsulated successfully, and the quantity of MX ranged from 37.23 ± 8.40 to 332.53 ± 13.37 μg was precisely controlled...
December 7, 2017: AAPS PharmSciTech
https://www.readbyqxmd.com/read/29217259/gender-differences-in-anomalous-subcortical-morphology-for-children-with-adhd
#5
Yanpei Wang, Qinfang Xu, Shuting Li, Gen Li, Chenyi Zuo, Shuirong Liao, Yang Long, Shan Li, R Malatesha Joshi
Although studies showed subtle reductions in brain volume in fronto-striatial regions in children with ADHD, there have been limited investigations of volume and lateralizaton in subcortical structures and a paucity of exploration of the influence of gender on these findings. This study aims to examine morphology of subcortical structures and their association with ADHD symptoms in boys and girls as compared to their typically-developing (TD) peers. One hundred and eighty five children aged 7-14 years with and without ADHD were included from ADHD-200 Consortium...
December 4, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/29216519/mine-is-better-than-yours-investigating-the-ownership-effect-in-children-with-autism-spectrum-disorder-and-typically-developing-children
#6
Calum Hartley, Sophie Fisher
Ownership has a unique and privileged influence on human psychology. Typically developing (TD) children judge their objects to be more desirable and valuable than similar objects belonging to others. This 'ownership effect' is due to processing one's property in relation to 'the self'. Here we explore whether children with autism spectrum disorder (ASD) - a population with impaired self-understanding - prefer and over-value property due to ownership. In Experiment 1, we discovered that children with ASD did not favour a randomly endowed toy and frequently traded for a different object...
December 4, 2017: Cognition
https://www.readbyqxmd.com/read/29215027/altered-human-voice-processing-in-the-frontal-cortex-and-a-developmental-language-delay-in-3-to-5-year-old-children-with-autism-spectrum-disorder
#7
Yuko Yoshimura, Mitsuru Kikuchi, Norio Hayashi, Hirotoshi Hiraishi, Chiaki Hasegawa, Tetsuya Takahashi, Manabu Oi, Gerard B Remijn, Takashi Ikeda, Daisuke N Saito, Hirokazu Kumazaki, Yoshio Minabe
The inferior frontal and superior temporal areas in the left hemisphere are crucial for human language processing. In the present study, we investigated the magnetic mismatch field (MMF) evoked by voice stimuli in 3- to 5-year-old typically developing (TD) children and children with autism spectrum disorder (ASD) using child-customized magnetoencephalography (MEG). The children with ASD exhibited significantly decreased activation in the left superior temporal gyrus compared with the TD children for the MMF amplitude...
December 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29213248/impact-of-diglossia-on-word-and-non-word-repetition-among-language-impaired-and-typically-developing-arabic-native-speaking-children
#8
Elinor Saiegh-Haddad, Ola Ghawi-Dakwar
The study tested the impact of the phonological and lexical distance between a dialect of Palestinian Arabic spoken in the north of Israel (SpA) and Modern Standard Arabic (StA or MSA) on word and non-word repetition in children with specific language impairment (SLI) and in typically developing (TD) age-matched controls. Fifty kindergarten children (25 SLI, 25 TD; mean age 5;5) and fifty first grade children (25 SLI, 25 TD; mean age 6:11) were tested with a repetition task for 1-4 syllable long real words and pseudo words; Items varied systematically in whether each encoded a novel StA phoneme or not, namely a phoneme that is only used in StA but not in the spoken dialect targeted...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29212690/quantifying-the-law-of-diminishing-returns-in-magnetically-controlled-growing-rods
#9
A Ahmad, T Subramanian, P Panteliadis, J Wilson-Macdonald, D A Rothenfluh, C Nnadi
AIMS: Magnetically controlled growing rods (MCGRs) allow non-invasive correction of the spinal deformity in the treatment of early-onset scoliosis. Conventional growing rod systems (CGRS) need repeated surgical distractions: these are associated with the effect of the 'law of diminishing returns'. The primary aim of this study was to quantify this effect in MCGRs over sequential distractions. PATIENTS AND METHODS: A total of 35 patients with a maximum follow-up of 57 months were included in the study...
December 2017: Bone & Joint Journal
https://www.readbyqxmd.com/read/29211927/breaking-unstrained-c-c-bond-in-acenes-by-boron-and-light-transformation-of-naphthalene-to-benzoborepin
#10
Suning Wang, Kang Yuan, Ming-Feng Hu, Xiang Wang, Tai Peng, Nan Wang, Quansong Li
Naphthalene and acenaphthene with peri 2-py and BMes2 (Mes = mesityl) substituents have been found to undergo facile phototransformation, cleaving a C-C bond of naphthalene and forming 2-py-bound benzoborepins as the major products. Mechanistic pathways of this new photoreaction are established by examining both excited and ground states using CASSCF and CASPT2 methods with DFT and TD-DFT. The Mes to py-naphthyl charge transfer transition and the Mes migration from boron to naphthyl drive this unprecedented C-C bond cleavage and boron insertion reaction...
December 6, 2017: Angewandte Chemie
https://www.readbyqxmd.com/read/29211685/optimisation-of-sampling-parameters-for-standardised-exhaled-breath-sampling
#11
Sophie L F Doran, Andrea Romano, George B Hanna
The lack of standardisation of breath sampling is a major contributing factor to the poor repeatability of results and hence represents a barrier to the adoption of breath tests in clinical practice. On-line and bag breath sampling have advantages but do not suit multicentre clinical studies whereas storage and robust transport are essential for the conduct of wide-scale studies. Several devices have been developed to control sampling parameters and to concentrate volatile organic compounds (VOCs) onto thermal desorption (TD) tubes and subsequently transport those tubes for laboratory analysis...
December 6, 2017: Journal of Breath Research
https://www.readbyqxmd.com/read/29210562/methacrylate-stitched-%C3%AE-cyclodextrin-embedded-with-nanogold-nanotitania-a-skin-adhesive-device-for-enhanced-transdermal-drug-delivery
#12
Thayyath Sreenivasan Anirudhan, Syam S Nair, Athira V Sasidharan
Transdermal (TD) drug delivery is an attractive technique for drug delivery compared to oral and intravenous injection. However the permeation of drug molecules across the skin is difficult due to the presence of highly ordered lipid barrier. This investigation details the development of a novel TD system, which has the potential to simultaneously enhance the skin permeability and adhesion behavior. Ibuprofen (IP) was selected as model drug. The ability of gold nanoparticle (AuNP) and hydrophobic titanium nanotube (TNT) to enhance the skin permeability was explored...
December 6, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/29209258/syntactic-and-story-structure-complexity-in-the-narratives-of-high-and-low-language-ability-children-with-autism-spectrum-disorder
#13
Eleni Peristeri, Maria Andreou, Ianthi M Tsimpli
Although language impairment is commonly associated with the autism spectrum disorder (ASD), the Diagnostic Statistical Manual no longer includes language impairment as a necessary component of an ASD diagnosis (American Psychiatric Association, 2013). However, children with ASD and no comorbid intellectual disability struggle with some aspects of language whose precise nature is still outstanding. Narratives have been extensively used as a tool to examine lexical and syntactic abilities, as well as pragmatic skills in children with ASD...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/29208878/study-of-thyroid-disorders-among-type-2-diabetic-patients-attending-a-tertiary-care-hospital
#14
N Z Khan, M A Muttalib, G S Sultana, F A Mishu, A Nesa
Type 2 diabetes mellitus (T2DM) and thyroid disorders (TD) are the two most common endocrine disorders in clinical practice. Unrecognized thyroid disorders may adversely affect the metabolic control and add more risk to an already predisposing type 2 diabetes mellitus. The objective of the study is to find out the percentage of hypothyroidism and hyperthyroidism in patients with type 2 diabetes mellitus and non diabetic subjects. This cross-sectional study was conducted in the department of Biochemistry and outpatient Department of Endocrinology, BIRDEM General Hospital, Dhaka, Bangladesh from July 2014 to June 2015...
October 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/29207234/vacuum-uv-polarization-spectroscopy-of-p-terphenyl
#15
Duy Duc Nguyen, Nykola C Jones, Søren Vrønning Hoffmann, Jens Spanget-Larsen
p-Terphenyl is used as a component in a variety of optical devices. In this investigation, the electronic transitions of p-terphenyl are investigated by synchrotron radiation linear dichroism (SRLD) spectroscopy in the range 30000 - 58000 cm-1 (330 - 170 nm) on molecular samples aligned in stretched polyethylene, thereby extending the region investigated by polarization spectroscopy into the vacuum UV. The resulting partial absorbance curves reveal that the vacuum UV band system with a maximum at 55000 cm-1 (180 nm) is predominantly short axis-polarized...
December 5, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/29204930/double-layer-carbon-nanocapsules-with-radioiodine-content-and-its-interaction-with-calcium-phosphorus-and-strontium
#16
Alejandro Valderrama, Radamés Reynoso, Raúl W Gómez, Manuel Quintana, Martín Romero
First principles calculations have been performed for C60@C180 carbon double-layer endofullerenes with up to: three diatomic radioiodine molecules (131I2), two potassium radio-iodide (K131I), and three sodium radio-iodide (Na131I) inside. The plane-wave pseudopotential (PP) method within the general gradient approximation (GGA) in the framework of the density functional theory (DFT) and time-dependent DFT (TD-DFT) was used to perform geometric optimizations (GOs) and molecular dynamics (MD) at 310 K and atmospheric pressure...
December 4, 2017: Journal of Molecular Modeling
https://www.readbyqxmd.com/read/29204740/living-with-conduct-problem-youth-family-functioning-and-parental-perceptions-of-their-child
#17
Ruth Roberts, Eamon McCrory, Helene Joffe, Nicole De Lima, Essi Viding
Parenting children with conduct problems (CP) is challenging, yet very little is known about the impact of the child's behaviour on family functioning or how parents of children with CP perceive their child. The aim of this research was to examine whether families with children with CP and high vs. low levels of callous-unemotional traits (HCU vs. LCU) experience differences in family functioning and parental perceptions. One hundred and one parents/caregivers of boys aged 11-16 [Typically developing (TD) n = 31; CP/HCU n = 35; CP/LCU n = 35] completed the McMaster Family Assessment Device, measuring multiple domains of family functioning...
December 4, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29202866/tracheostomy-decannulation-methods-and-procedures-in-adults-a-systematic-scoping-review-protocol
#18
John Kutsukutsa, Tivani Phosa Mashamba-Thompson, Yougan Saman
BACKGROUND: The indications for and the number of tracheostomy procedures has increased with advances in critical care. Studies are indicating likely continued increase in number of tracheostomies. Despite the important benefits of a tracheostomy, its presence is associated with adverse health complications and lowered patient quality of life. Hence, it must be decannulated as soon as it is no longer indicated in a safe and effective manner. There is, however, no agreed universal standard of care for tracheostomy decannulation (TD) in adults...
December 4, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29200736/induction-of-apoptosis-by-tithonia-diversifolia-in-human-hepatoma-cells
#19
Min-Ren Lu, Huey-Lan Huang, Wen-Fei Chiou, Ray-Ling Huang
Background: Traditional Chinese herb Tithonia diversifolia, belonging to the Compositae family, has long been applied for the treatment of liver diseases. In recent years, many reports also indicated that it possesses hepato-protective, anti-inflammatory, and anti-cancer activities. Objective: In this study, we evaluated whether T. diversifolia is an effective therapy for hepatocellular carcinoma (HCC). Materials and Methods: Dry leaves of T...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29200224/controlling-the-emission-in-flexibly-linked-n-c-n-platinum-dyads
#20
Eleonora Garoni, Julien Boixel, Vincent Dorcet, Thierry Roisnel, Dominique Roberto, Denis Jacquemin, Véronique Guerchais
The synthesis, spectroscopic and theoretical characterizations of dinuclear Pt(ii) complexes where the two chromophoric units are connected though a polyether chain via either the central benzene ring of the tridentate ligand dpyb (Pt-2), or the phenylacetylide ligand (Pt-3), are described. The spacer, which contains four oxyethylene -CH2CH2O- units, is flexible and long enough to allow a self-association of the Pt units by folding, as shown by DFT calculations. Comparison of the photophysical properties of the dinuclear complex Pt-2 with those of the mononuclear complex Pt-1, used as reference, demonstrates the key role played by the linker group in the interaction processes...
December 4, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
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