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Neuroleptic malignant syndrom

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https://www.readbyqxmd.com/read/29698346/a-mixed-presentation-of-serotonin-syndrome-vs-neuroleptic-malignant-syndrome-in-a-12-year-old-boy
#1
Christie Sun, Hannah Sweet, Alicia B Minns, Desiree Shapiro, Willough Jenkins
BACKGROUND: Neuroleptic malignant syndrome (NMS) and serotonin syndrome (SS) are serious medical conditions associated with commonly prescribed psychiatric medications. Although the mechanisms differ, they can be clinically difficult to distinguish. We report a case of a pediatric patient with complicated psychiatric history that developed features of both syndromes in the setting of polypharmacy. CASE: A 12-year-old boy with a history of developmental delay, attention-deficit hyperactivity disorder, and posttraumatic stress disorder presented to the emergency department with behavior changes consisting of delayed reactions, gait instability, drooling, and slowed movements...
April 24, 2018: Pediatric Emergency Care
https://www.readbyqxmd.com/read/29696960/reversible-splenial-lesion-in-neuroleptic-malignant-syndrome
#2
Alessandra Gasparini, Nicola Poloni, Ivano Caselli, Marta Ielmini, Camilla Callegari
No abstract text is available yet for this article.
April 24, 2018: Panminerva Medica
https://www.readbyqxmd.com/read/29666709/anesthetic-considerations-for-an-adult-patient-with-freeman-sheldon-syndrome-undergoing-open-heart-surgery
#3
S Viehmeyer, P Gabriel, K Bauer, S Bauer, R Sodian, J N Hilberath
Freeman-Sheldon syndrome (FSS) or "whistling face" syndrome is a rare congenital disorder complicated by characteristic facial deformities and muscular contractures. We report on a 64-year-old male patient presenting for surgical replacement of his aortic valve and review the available literature on anesthetic considerations and perioperative management principles. FSS frequently poses a significant challenge to airway management and gaining vascular access. Moreover, these patients are reportedly at risk for developing malignant hyperthermia (MH) or neuroleptic malignant syndrome...
2018: Case Reports in Anesthesiology
https://www.readbyqxmd.com/read/29628214/-neuroleptic-malignant-syndrome-after-withdrawal-of-levopoda
#4
Bernardo Cedeno-Veloz, Almudena Areosa Sastre
No abstract text is available yet for this article.
April 5, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29616715/serotonin-syndrome-versus-neuroleptic-malignant-syndrome-a-case-report
#5
Mercedes Fernández, Laura Lago, M Gema Alonso, Ana Guede, Jose Luis Benavente, Jose M Olivares
No abstract text is available yet for this article.
March 2018: Actas Españolas de Psiquiatría
https://www.readbyqxmd.com/read/29548378/dantrolene-for-treatment-of-suspected-neuroleptic-malignant-syndrome
#6
Colleen J Whyte, Jamie M Rosini
No abstract text is available yet for this article.
March 2018: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29523295/molecular-hypotheses-to-explain-the-shared-pathways-and-underlying-pathobiological-causes-in-catatonia-and-in-catatonic-presentations-in-neuropsychiatric-disorders
#7
E M Peter-Ross
The pathobiological causes, the shared cellular and molecular pathways in catatonia and in catatonic presentation in neuropsychiatric disorders are yet to be determined. The hypotheses in this paper have been deduced from the latest scientific research findings and clinical observations of patients with genetic disorders, behavioral phenotypes and other family members suffering mental disorders. The first hypothesis postulates that catatonia and the heterogeneity of catatonic signs and symptoms involve nucleolar dysfunction arising from abnormalities of the brain-specific, non-coding micro-RNA, SNORD115 genes (either duplications or deletions) which result in pathobiological dysfunction of various combinations in the downstream pathways (possibly along with other genes in these shared pathways)...
April 2018: Medical Hypotheses
https://www.readbyqxmd.com/read/29521882/catatonic-stupor-in-schizophrenic-disorders-and-subsequent-medical-complications-and-mortality
#8
Michitaka Funayama, Taketo Takata, Akihiro Koreki, Satoyuki Ogino, Masaru Mimura
OBJECTIVE: Although catatonia can occur secondary to a general medical condition, catatonia itself has been known to lead to various medical compolications. Although case reports on the association of catatonia with subsequent medical complications have been documented, no comprehensive large-scale study has been performed. To investigate specific medical complications after catatonia, we conducted a retrospective cohort study of specific medical complications of schizophrenia patients with catatonia...
May 2018: Psychosomatic Medicine
https://www.readbyqxmd.com/read/29505490/clozapine-rechallenge-after-major-adverse-effects-clinical-guidelines-based-on-259-cases
#9
Peter Manu, Yevgeniya Lapitskaya, Atef Shaikh, Jimmi Nielsen
BACKGROUND: Clozapine is widely prescribed for treatment-refractory schizophrenia, but its use is limited by many potentially life-threatening adverse effects. The risk of rechallenge after these complications has never been comprehensively assessed in controlled studies. Thus, clinical guidelines must rely on the published case reports. The number of such reports is likely to increase over time, and updated analyses of larger samples are needed, as they may lead to changes in clinical guidelines...
March 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29475219/a-neuroleptic-malignant-syndrome-without-rigidity
#10
İlker Özdemir, Erkan Kuru, Yasir Safak, Rıza Gökçer Tulacı
Neuroleptic malignant syndrome (NMS) is an uncommon but potentially lethal idiosyncratic reaction which may emerge in the aftermath of the treatments with neuroleptics demonstrating itself with the symptoms of altered consciousness, high fever, impaired autonomic functions, and muscle rigidity. Although various risk factors have been identified for NMS, its etiology is not completely known. The mortality and morbidity related with NMS could be reduced by early diagnosis, interruption of the neuroleptics used within a short period and aggressive treatment...
February 2018: Psychiatry Investigation
https://www.readbyqxmd.com/read/29464897/case-report-of-neuroleptic-malignant-syndrome-with-prolonged-mental-changes-and-severe-dyskinesia
#11
Youn Jae Chung, Seung Jae Lee
No abstract text is available yet for this article.
March 2018: Asia-Pacific Psychiatry: Official Journal of the Pacific Rim College of Psychiatrists
https://www.readbyqxmd.com/read/29464217/a-retrospective-analysis-of-cases-with-neuroleptic-malignant-syndrome-and-an-evaluation-of-risk-factors-for-mortality
#12
Aynur Sahin, Mustafa Cicek, Ozgen Gonenc Cekic, Mucahit Gunaydin, Demet Saglam Aykut, Ozgur Tatli, Yunus Karaca, Mualla Aylin Arici
Objective: Neuroleptic malignant syndrome (NMS) is a neurological emergency rarely encountered in clinical practice but with a high mortality rate. Cases associated with atypical antipsychotic use or termination of dopamine agonists have been seen in recent years. The purpose of this study was to assess the presence of risk factors for mortality by investigating all clinical and laboratory characteristics of cases with NMS. Material and methods: This descriptive, cross-sectional study retrospectively investigated all clinical and laboratory characteristics by scanning the ICD-10 codes of patients presenting to the XXXX Faculty of Medicine Emergency Department and diagnosed with NMS between 2006 and 2016...
December 2017: Turkish Journal of Emergency Medicine
https://www.readbyqxmd.com/read/29441189/neuroleptic-malignant-syndrome-a-case-responding-to-electroconvulsive-therapy-plus-bupropion
#13
Quintí Foguet-Boreu, Montse Coll-Negre, Montse Serra-Millàs, Miquel Cavalleria-Verdaguer
Neuroleptic malignant syndrome (NMS) is a severe motor syndrome occurring as a consequence of neuroleptic treatment. We present a case of a 67-year-old Caucasian woman with a history of a major depressive disorder with psychotic features. During her third hospital admission, symptoms of autonomic instability, hyperpyrexia, severe extrapyramidal side effects, and delirium appeared, suggesting NMS due to concomitant treatment with risperidone and quetiapine, among other drugs. Despite several consecutive pharmacological treatments (lorazepam, bromocriptine and amantadine) and prompt initiation of electroconvulsive therapy (ECT), clinical improvement was observed only after combining bupropion with ECT...
January 8, 2018: Clinics and Practice
https://www.readbyqxmd.com/read/29363376/neuroleptic-malignant-syndrome-in-pregnancy-case-report-and-literature-review
#14
Maria Fernanda Escobar-Vidarte, Sara Loaiza-Osorio, Adriana A Messa, Gloria Elena Macías
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a serious complication associated with the use of drugs that affect dopaminergic system neurotransmission. The occurrence of NMS during pregnancy or gestation is considered a life-threatening obstetric emergency. CASE: We are reporting the first case in Latin America of NMS in one pregnant women with acute psychotic episode. One day after starting with antipsychotic therapy, she developed a fever higher than 39...
February 5, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29325237/neuroleptic-malignant-syndrome-diagnosis-and-management
#15
Michael R Ware, David B Feller, Karen L Hall
Objective: To provide an overview of neuroleptic malignant syndrome (NMS) for the general practitioner with the most up-to-date information on etiology, workup, and management. Data Sources: The search using PubMed included articles with the key words neuroleptic malignant syndrome, antipsychotics, neuroleptics, diagnosis, and treatment of neuroleptic malignant syndrome published in English from January 2000 to 2017. Single-case reports and articles dealing with the pediatric patient population were excluded...
January 4, 2018: Primary Care Companion to CNS Disorders
https://www.readbyqxmd.com/read/29243130/neuroleptic-malignant-syndrome-as-a-presenting-feature-of-subacute-sclerosing-panencephalitis
#16
Divyani Garg, Varun Reddy, Rajesh Kumar Singh, Deepa Dash, Rohit Bhatia, Manjari Tripathi
Subacute sclerosing panencephalitis (SSPE) is a slowly progressive degenerative disorder caused by measles virus. It is characterised by typical clinical and electrophysiological features in the form of slow myoclonic jerks, with progressive cognitive impairment, visual symptoms, and periodic complexes on EEG, with raised titres of anti-measles antibodies in CSF and serum. Atypical presentations of SSPE have been reported including brainstem involvement, ADEM-like presentation, acute encephalitis, and cerebellar ataxia...
February 2018: Journal of Neurovirology
https://www.readbyqxmd.com/read/29233537/life-threatening-parkinsonism-hyperpyrexia-syndrome-following-bilateral-deep-brain-stimulation-of-the-subthalamic-nucleus
#17
Mehmet Osman Akçakaya, Nihan Hande Akçakaya, Mustafa Ömür Kasımcan, Talat Kırış
Parkinsonism-hyperpyrexia syndrome (PHS), or neuroleptic malignant syndrome (NMS), is a neurophysiologic reaction to the acute withdrawal/decrease of central dopamine levels. It is a severe complication characterized by rigidity, change in consciousness level, fever, hypertension, and autonomic instability, that can be fatal. To the best of our knowledge, PHS following deep brain stimulation (DBS) of subthalamic nucleus (STN) surgery due to anti-Parkinson drug discontinuation has been previously reported only six times...
December 6, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29230342/the-treatment-of-clozapine-withdrawal-delirium-with-electroconvulsive-therapy
#18
Anish Modak, Arne Åhlin
Clozapine, a commonly used atypical antipsychotic, can precipitate a severe withdrawal syndrome. In this report, we describe a case of delirium with catatonic features emerging after the immediate cessation of clozapine subsequent to concerns of developing neuroleptic malignant syndrome. After multiple treatments were found to be inefficacious, electroconvulsive therapy (ECT) was initiated, resulting in significant improvement. A literature search revealed six previous cases of clozapine-withdrawal syndromes of varied symptomatology treated with ECT...
2017: Case Reports in Psychiatry
https://www.readbyqxmd.com/read/29209753/-neuroleptic-malignant-syndrome
#19
REVIEW
R Knorr, J Schöllkopf, E Haen
BACKGROUND: Neuroleptic malignant syndrome (NMS) is a rare but severe undesired complication of psychopharmacological treatment. The mortality has shown a significant decrease since its first description. Knowledge of NMS is important for every clinician because of the need for rapid diagnosis and treatment. OBJECTIVE: This article presents a review and critical appraisal of the current study situation for NMS. Recommendations for diagnostics, differential diagnostics and treatment are presented particularly from a clinical perspective...
March 2018: Der Nervenarzt
https://www.readbyqxmd.com/read/29207768/controversies-in-serotonin-syndrome-diagnosis-and-management-a-review
#20
REVIEW
Mohd Faisal Uddin, Richard Alweis, Syed Raza Shah, Noman Lateef, Waqas Shahnawaz, Rohan Kumar Ochani, Amin Muhammad Dharani, Syed Arbab Shah
Over the past few years, Serotonin Syndrome (SS) has become a significant clinical concern. Over the last decade, United States saw a surge in antidepressant use. SS characteristically presents as the triad of altered mental status, autonomic dysfunction and neuromuscular excitation. Symptoms vary from patient to patient with mild cases presenting with subacute symptoms and severe cases progressing rapidly to death. Due to the protean manifestations of the syndrome along with non-specific prodromal, SS can easily be misdiagnosed if not carefully assessed...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
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