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T Klingelfus, J R Lirola, L F Oya Silva, G R Disner, M Vicentini, M J B Nadaline, J C Z Robles, L M Trein, C L Voigt, H C Silva de Assis, M Mela, D M Leme, M M Cestari
Nanotechnologies are at the center of societal interest, due to their broad spectrum of application in different industrial products. The current concern about nanomaterials (NMs) is the potential risks they carry for human health and the environment. Considering that NMs can reach bodies of water, there is a need for studying the toxic effects of NMs on aquatic organisms. Among the NMs' toxic effects on fish, the interactions between NMs and the nervous system are yet to be understood. For this reason, our goal was to assess the neurotoxicity of polyvinylpyrrolidone coated silver nanospheres [AgNS (PVP coated)] and compare their effects in relation to silver ions (Ag(+)) in carnivorous Hoplias intermedius fish after acute and subchronic trophic exposure through the analysis of morphological (retina), biochemical (brain) and genetic biomarkers (brain and blood)...
October 11, 2017: Neurotoxicology
Jaewook Lee, Kenshin Takemura, Enoch Y Park
Plasmonic nanomaterials (P-NM) are receiving attention due to their excellent properties, which include surface-enhanced Raman scattering (SERS), localized surface plasmon resonance (LSPR) effects, plasmonic resonance energy transfer (PRET), and magneto optical (MO) effects. To obtain such plasmonic properties, many nanomaterials have been developed, including metal nanoparticles (MNP), bimetallic nanoparticles (bMNP), MNP-decorated carbon nanotubes, (MNP-CNT), and MNP-modified graphene (MNP-GRP). These P-NMs may eventually be applied to optical biosensing systems due to their unique properties...
October 13, 2017: Sensors
Manoj Kumar Sahoo, Sangita Kamath, Abhijeet Sharan
Neuroleptic malignant syndrome (NMS), a potentially fatal consequence due to typical neuroleptics, has been described so far. In the past few years, there has been increased use of atypical antipsychotic drugs. Cases of NMS related to atypical neuroleptics, such as olanzapine, are less common in spite of increasing cases reported in literatures. Here, we report a case of NMS in a patient with bipolar affective disorder on maintenance treatment with 5 mg olanzapine for the last 7 year. He was successfully treated with bromocriptine and discharged in stable condition in 10 days...
January 2017: Journal of Family Medicine and Primary Care
Vian Sabri Akrawi, Tariq Salman Al-Hadithi, Namir Ghanim Al-Tawil
OBJECTIVES: To find out the major determinants of maternal near-miss (NM)and maternal deaths (MDs) in Erbil city, Iraq, by comparative analysis of maternal NMs and MDs. METHODS: We conducted a hospital-based cross-sectional study in the Maternity Teaching Hospital in Erbil city from 1 June to 31 December 2013. All MDs and NMs that occurred in the hospital during the study period were included in the study. Systematic identification of all eligible women was done...
September 2017: Oman Medical Journal
Sung Ho Lee, Ji Hyun Yang, Hye Ran Yim, Jungwae Park, Seung-Jung Park, Kyoung-Min Park, Young Keun On, June Soo Kim
BACKGROUND: We aimed to investigate differences in hemodynamic parameters and the role of baroreflex sensitivity (BRS) in patients with a history of neurally mediated syncope (NMS) compared with a control group. METHODS: Hemodynamic parameters and BRS were continuously measured non-invasively using a Finometer at rest and during passive head-up tilt test (HUT) in patients with a history of NMS (n = 55) and a control group (n = 77). The tilting period was divided into pretest (resting supine position), initial (first 3 minutes of tilting), last (last 3 minutes of tilting), and recovery (3 minutes after tilting was complete) periods...
October 10, 2017: Pacing and Clinical Electrophysiology: PACE
Vicki Stone, Mark R Miller, Martin J D Clift, Alison Elder, Nicholas L Mills, Peter Møller, Roel P F Schins, Ulla Vogel, Wolfgang G Kreyling, Keld Alstrup Jensen, Thomas A J Kuhlbusch, Per E Schwarze, Peter Hoet, Antonio Pietroiusti, Andrea De Vizcaya-Ruiz, Armelle Baeza-Squiban, João Paulo Teixeira, C Lang Tran, Flemming R Cassee
BACKGROUND: A rich body of literature exists that has demonstrated adverse human health effects following exposure to ambient air particulate matter (PM), and there is strong support for an important role of ultrafine (nanosized) particles. At present, relatively few human health or epidemiology data exist for engineered nanomaterials (NMs) despite clear parallels in their physicochemical properties and biological actions in in vitro models. OBJECTIVES: NMs are available with a range of physicochemical characteristics, which allows a more systematic toxicological analysis...
October 10, 2017: Environmental Health Perspectives
Ahmed Barhoum, Pieter Samyn, Thomas Öhlund, Alain Dufresne
Traditional paper and papermaking have struggled with a declining market during the last few decades. However, the incorporation of nanotechnology into papermaking has brought possibilities to develop low-cost, biocompatible and flexible products with sophisticated functionalities. The functionality of nanopapers emerges from the intrinsic properties of the nanofibrous network, the additional loading of specific nanomaterials (NMs), or the additional deposition and patterning of thin films of nanomaterials on the paper surface...
October 9, 2017: Nanoscale
B Morissette, G Talbot, C Beaulieu, M Lessard
The aim of this study was to evaluate the effect of newborn piglet weight gain during the first 2 weeks of lactation on the luminal and mucosal microbiota of the ileum and colon. The microbiota from high-weight-gain (HWG) and low-weight-gain (LWG) 2-week-old piglets was characterized by amplicon length heterogeneity PCR (LH-PCR) and compared using diversity indices and multivariate statistical analyses. At birth, LWG piglets weighted in average 0.26 kg less than HWG piglets (p = .002). The weight difference between LWG and HWG piglets increased with time and reached 2...
October 9, 2017: Journal of Animal Physiology and Animal Nutrition
Tanya Simuni, Chelsea Caspell-Garcia, Christopher S Coffey, Daniel Weintraub, Brit Mollenhauer, Shirley Lasch, Caroline M Tanner, Danna Jennings, Karl Kieburtz, Lana M Chahine, Kenneth Marek
OBJECTIVE: To examine the baseline prevalence and longitudinal evolution in non-motor symptoms (NMS) in a prospective cohort of, at baseline, patients with de novo Parkinson's disease (PD) compared with healthy controls (HC). METHODS: Parkinson's Progression Markers Initiative (PPMI) is a longitudinal, ongoing, controlled study of de novo PD participants and HC. NMS were rated using the Movement Disorder Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) Part I score and other validated NMS scales at baseline and after 2 years...
October 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
Jesse Mu, Kallol R Chaudhuri, Concha Bielza, Jesus de Pedro-Cuesta, Pedro Larrañaga, Pablo Martinez-Martin
Parkinson's disease is now considered a complex, multi-peptide, central, and peripheral nervous system disorder with considerable clinical heterogeneity. Non-motor symptoms play a key role in the trajectory of Parkinson's disease, from prodromal premotor to end stages. To understand the clinical heterogeneity of Parkinson's disease, this study used cluster analysis to search for subtypes from a large, multi-center, international, and well-characterized cohort of Parkinson's disease patients across all motor stages, using a combination of cardinal motor features (bradykinesia, rigidity, tremor, axial signs) and, for the first time, specific validated rater-based non-motor symptom scales...
2017: Frontiers in Aging Neuroscience
Irina G Minko, Carmelo J Rizzo, R Stephen Lloyd
Nitrogen mustards (NMs) are DNA-alkylating compounds that represent the earliest anticancer drugs. However, clinical use of NMs is limited because of their own mutagenic properties. The mechanisms of NM-induced mutagenesis remain unclear. The major product of DNA alkylation by NMs is a cationic NM-N7-dG adduct that can yield the imidazole ring-fragmented lesion, N(5)-NM substituted formamidopyrimidine (NM-Fapy-dG). Characterization of this adduct is complicated because it adopts different conformations, including both a canonical β- and an unnatural α-anomeric configuration...
September 28, 2017: Journal of Biological Chemistry
Ajey Singh, N B Singh, Imtiyaz Hussain, Himani Singh
Study on the ecological effect of metal oxide nanomaterials (NMs) has quickly amplified over the precedent years because it is assumed that these NMs will sooner or later be released into the environment. The present study deals with biologically oriented process for the green synthesis of copper oxide nanoparticles (CuO NPs) by using Morus alba leaf extract as reducing agent. Powder X-ray diffraction (XRD) and transmission electron microscope (TEM) analysis revealed the monoclinic phase and 20-40nm size respectively...
September 28, 2017: Journal of Biotechnology
Rasel Das, Chad D Vecitis, Agnes Schulze, Bin Cao, Ahmad Fauzi Ismail, Xianbo Lu, Jiping Chen, Seeram Ramakrishna
The efficient handling of wastewater pollutants is a must, since they are continuously defiling limited fresh water resources, seriously affecting the terrestrial, aquatic, and aerial flora and fauna. Our vision is to undertake an exhaustive examination of current research trends with a focus on nanomaterials (NMs) to considerably improve the performance of classical wastewater treatment technologies, e.g. adsorption, catalysis, separation, and disinfection. Additionally, NM-based sensor technologies are considered, since they have been significantly used for monitoring water contaminants...
September 29, 2017: Chemical Society Reviews
Wing-Lam Poon, Harri Alenius, Joseph Ndika, Vittorio Fortino, Vesa Kolhinen, Arūnas Meščeriakovas, Mingfu Wang, Dario Greco, Anna Lähde, Jorma Jokiniemi, Jetty Chung-Yung Lee, Hani El-Nezami, Piia Karisola
Nano-sized metal oxides are currently the most manufactured nanomaterials (NMs), and are increasingly used in consumer products. Recent exposure data reveal a genuine potential for adverse health outcomes for a vast array of NMs, however the underlying mechanisms are not fully understood. To elucidate size-related molecular effects, differentiated THP-1 cells were exposed to nano-sized materials (n-TiO2, n-ZnO and n-Ag), or their bulk-sized (b-ZnO and b-TiO2) or ionic (i-Ag) counterparts, and genome-wide gene expression changes were studied at low-toxic concentrations (<15% cytotoxicity)...
September 29, 2017: Nanotoxicology
Lynda Olender
OBJECTIVE: The aim of this study was to examine the relationship between, and factors influencing, staff nurse perceptions of nurse manager caring (NMC) and the perceived exposure to workplace bullying (WPB) in multiple healthcare settings. BACKGROUND: Workplace bullying is commonplace, increasing, and detrimental to the health and availability of our nursing workforce. Positive relationships between a nurse manager (NM) and staff increase staff satisfaction and reduce turnover...
October 2017: Journal of Nursing Administration
Srishti Shrestha, Freya Kamel, David M Umbach, Laura E Beane Freeman, Stella Koutros, Michael Alavanja, Dale P Sandler, Honglei Chen
OBJECTIVES: Few studies have evaluated the presence of multiple nonmotor symptoms (NMS) in relation to Parkinson disease (PD). Therefore, we examined cross-sectional associations between individual and multiple NMS and PD in the Agricultural Health Study. METHODS: 20,473 male farmers and 16,259 female spouses provided information on six NMS (reduced sense of smell, dream-enacting behavior, daytime sleepiness, infrequent bowel movement, depression, and anxiety) in the cohort's 2013-2015 follow-up survey...
2017: PloS One
Fan Zhang, Parisa Kanzali, Vadim Rubin, Chris Paras, Joel Goldman
RATIONALE: Neuroleptic malignant syndrome (NMS) is a life threatening neurologic emergency associated with neuroleptic or antipsychotic agent use. NMS is rarely related to thyroid disease. PATIENT CONCERNS: We report a case of NMS in a 66-year-old male with past medical history of paranoid schizophrenia on chlorpromazine, diabetes, hypertension and asthma, who presented with a humeral fracture after a fall. Patient developed hyperpyrexia, altered consciousness, autonomic instability, elevated serum creatine kinase (CK) without rigidity...
September 2017: Medicine (Baltimore)
Naoto Mizumura, Masato Uematu, Aya Ito, Satoshi Okumura, Hiromitsu Maehira, Masao Ogawa, Masayasu Kawasaki
Neuroleptic malignant syndrome (NMS) with characteristic symptoms is a potentially lethal reaction to antipsychotic drugs. Atypical NMS usually lacks major symptoms and frequently occurs after treatment using atypical antipsychotics, such as aripiprazole. A 64-year-old man developed aripiprazole-induced NMS after surgery, and our early recognition of the NMS was based on high creatine kinase levels and low serum iron levels. His characteristic symptoms (a fever, rigidity, and altered mental status) were only present for a few hours and were resolved by aripiprazole discontinuation and supportive care...
September 25, 2017: Internal Medicine
A E de Oliveira, A Iwahara, P A L da Cruz, C J da Silva, E B de Araújo, J Mengatti, R L da Silva, O L Trindade
Traceability in Nuclear Medicine Service (NMS) measurements was checked by the Institute of Radioprotection and Dosimetry (IRD) through the Institute of Energy and Nuclear Research (IPEN). In 2016, IRD ran an intercomparison program and invited Brazilian NMS authorized to administer (131)I to patients. Sources of (131)I were distributed to 33 NMSs. Three other sources from the same solution were sent to IRD, after measurement at IPEN. These sources were calibrated in the IRD reference system. A correction factor of 1...
August 1, 2017: Applied Radiation and Isotopes
Ye Liu, Bereket Workalemahu, Xingyu Jiang
Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of NMs cellular uptake between in vitro and in vivo, a focus on reviewing recent works about the effects of four physicochemical parameters of NMs (size, rigidity, shape, surface modification) on regulating NMs cellular uptake in vitro and in vivo is undertaken. This review can provide readers some useful clues and new thinking for understanding NMs cellular uptake in depth...
September 20, 2017: Small
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