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https://www.readbyqxmd.com/read/28106222/digestibility-and-supramolecular-structural-changes-of-maize-starch-by-non-covalent-interactions-with-gallic-acid
#1
Chengdeng Chi, Xiaoxi Li, Yiping Zhang, Ling Chen, Lin Li, Zhijiang Wang
The effects of non-covalent interactions between gallic acid (GA) and starch on starch digestibility and supramolecular structural changes (short-range ordered molecular structure, crystalline structure, lamellar structure and fractal structure) were investigated. The results indicated that the digestibility of both starches was substantially reduced in the rapidly digestible starch (RDS) content, but resistant starch (RS) was increased after interacting with GA. The RS content of starch-GA complexes ranged from 17...
January 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28095787/the-effects-of-habitual-functional-training-on-physical-functioning-in-patients-after-hip-fracture-the-protocol-of-the-hipfrac-study
#2
Kristi Elisabeth Heiberg, Vigdis Bruun-Olsen, Astrid Bergland
BACKGROUND: The survivors after hip fracture often report severe pain and loss of physical functioning. The poor outcomes cause negative impact on the person's physical functioning and quality of life and put a financial burden on society. Rehabilitation is important to improve physical functioning after hip fracture. To maintain the continuity in rehabilitation we have an assumption that it is of utmost importance to continue and progress the functional training that already started at the hospital, while the patients are transferred to short-term stays in a nursing home before they are returning to home...
January 17, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28094527/binding-and-inhibitory-effect-of-dyes-amaranth-and-tartrazine-on-amyloid-fibrillation-in-lysozyme
#3
Anirban Basu, Gopinatha Suresh Kumar
Interaction of two food colorant dyes, amaranth and tartrazine, with lysozyme was studied employing multiple biophysical techniques. The dyes exhibited hypochromic changes in the presence of lysozyme. The intrinsic fluorescence of lysozyme was quenched by both dyes; amaranth was a more efficient quencher than tartrazine. The equilibrium constant of amaranth was higher than that of tartarzine. From FRET analysis, the binding distances for amaranth and tartrazine were calculated to be 4.51 and 3.93 nms, respectively...
January 17, 2017: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/28091608/binding-of-n-methylscopolamine-to-the-extracellular-domain-of-muscarinic-acetylcholine-receptors
#4
Jan Jakubík, Alena Randáková, Pavel Zimčík, Esam E El-Fakahany, Vladimír Doležal
Interaction of orthosteric ligands with extracellular domain was described at several aminergic G protein-coupled receptors, including muscarinic acetylcholine receptors. The orthosteric antagonists quinuclidinyl benzilate (QNB) and N-methylscopolamine (NMS) bind to the binding pocket of the muscarinic acetylcholine receptor formed by transmembrane α-helices. We show that high concentrations of either QNB or NMS slow down dissociation of their radiolabeled species from all five subtypes of muscarinic acetylcholine receptors, suggesting allosteric binding...
January 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28088171/assessing-the-sustainability-of-daily-chlorhexidine-bathing-in-the-intensive-care-unit-of-a-veteran-s-hospital-by-examining-nurses-perspectives-and-experiences
#5
Jackson S Musuuza, Tonya J Roberts, Pascale Carayon, Nasia Safdar
BACKGROUND: Daily bathing with chlorhexidine gluconate (CHG) of intensive care unit (ICU) patients has been shown to reduce healthcare-associated infections and colonization by multidrug resistant organisms. The objective of this project was to describe the process of daily CHG bathing and identify the barriers and facilitators that can influence its successful adoption and sustainability in an ICU of a Veterans Administration Hospital. METHODS: We conducted 26 semi-structured interviews with a convenience sample of 4 nurse managers (NMs), 13 registered nurses (RNs) and 9 health care technicians (HCTs) working in the ICU...
January 14, 2017: BMC Infectious Diseases
https://www.readbyqxmd.com/read/28079981/inhibiting-solid-tumor-growth-in-vivo-by-non-tumor-penetrating-nanomedicine
#6
Shixian Lv, Zhaohui Tang, Wantong Song, Dawei Zhang, Mingqiang Li, Huaiyu Liu, Jianjun Cheng, Wu Zhong, Xuesi Chen
Nanomedicine (NM) cannot penetrate deeply into solid tumors, which is partly attributed to the heterogeneous microenvironment and high interstitial fluid pressure of solid tumors. To improve NM efficacy, there has been tremendous effort developing tumor-penetrating NMs by miniaturizing NM sizes or controlling NM surface properties. But progress along the direction of developing tumor penetrating nanoparticle has been slow and improvement of the overall antitumor efficacy has been limited. Herein, a novel strategy of inhibiting solid tumor with high efficiency by dual-functional, nontumor-penetrating NM is demonstrated...
January 12, 2017: Small
https://www.readbyqxmd.com/read/28067656/magnetite-nanoparticles-influence-the-ammonium-oxidizing-bacteria-activity-during-nitritation-process
#7
Simone Perazzoli, Camila Michels, Hugo M Soares
With nanotechnology dissemination, nanomaterials' (NMs) release into the environment is inevitable and may adversely affect the wastewater treatment processes. Among the NMs, the iron oxide nanoparticles have a considerable commercial potential, mainly because their magnetic properties, high catalytic ability and antimicrobial activity. However, few studies have examined their potential effect on the biological wastewater treatment. In this process, ammonium-oxidizing bacteria (AOB) are sensitive to the presence of inhibitory compounds and are useful as biosensors to assess contaminant toxicity information...
January 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/28067334/strong-ductile-and-thermally-stable-cu-based-metal-intermetallic-nanostructured-composites
#8
Keith J Dusoe, Sriram Vijayan, Thomas R Bissell, Jie Chen, Jack E Morley, Leopolodo Valencia, Avinash M Dongare, Mark Aindow, Seok-Woo Lee
Bulk metallic glasses (BMGs) and nanocrystalline metals (NMs) have been extensively investigated due to their superior strengths and elastic limits. Despite these excellent mechanical properties, low ductility at room temperature and poor microstructural stability at elevated temperatures often limit their practical applications. Thus, there is a need for a metallic material system that can overcome these performance limits of BMGs and NMs. Here, we present novel Cu-based metal-intermetallic nanostructured composites (MINCs), which exhibit high ultimate compressive strengths (over 2 GPa), high compressive failure strain (over 20%), and superior microstructural stability even at temperatures above the glass transition temperature of Cu-based BMGs...
January 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28064146/chronic-exposure-of-zinc-oxide-nanoparticles-causes-deviant-phenotype-in-drosophila-melanogaster
#9
Avnika Singh Anand, Dipti N Prasad, Shashi Bala Singh, Ekta Kohli
Zinc oxide nanoparticles (ZnO NPs) are commonly used nanomaterials (NMs) with versatile applications from high-end technologies to household products. This pervasive utilisation has brought human in the close interface with nanoparticles (NPs), hence questioning their safety prior to usage is a must. In this study, we have assessed the effects of chronic exposure to ZnO NPs (<50nm) on the model organism Drosophila melanogaster. Potential toxic effects were studied by evaluating longevity, climbing ability, oxidative stress and DNA fragmentation...
December 23, 2016: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28064050/development-of-a-novel-ph-sensitive-silane-crosslinked-injectable-hydrogel-for-controlled-release-of-neomycin-sulfate
#10
Sehrish Jabeen, Atif Islam, Abdul Ghaffar, Nafisa Gull, Ayesha Hameed, Anbreen Bashir, Tahir Jamil, Tousif Hussain
Silane crosslinked biopolymer based novel pH-responsive hydrogels were fabricated by blending the cationic (chitosan) and anionic (alginate) polymers with poly(vinyl alcohol). Tetraethoxysilane (TEOS) was used, as a crosslinker in different amounts due to its nonhazardous nature, to study its impact on physical and chemical properties of the prepared injectable hydrogels along with the controlled release of drug. The swelling response of the prepared hydrogels was examined in different solvent media which exhibited decreased swelling ratio with increase in the amount of TEOS...
January 4, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28063369/physiological-and-biochemical-responses-of-two-keystone-polychaete-species-diopatra-neapolitana-and-hediste-diversicolor-to-multi-walled-carbon-nanotubes
#11
Lucia De Marchi, Victor Neto, Carlo Pretti, Etelvina Figueira, Federica Chiellini, Amadeu M V M Soares, Rosa Freitas
Multi-walled carbon nanotubes (MWCNTs) are one of the most important carbon Nanomaterials (NMs). The production and use of these carbon NMs is increasing rapidly and, therefore, the need to assess their presence in the environment and associated risks has become increasingly important. However, limited literature is available regarding the impacts induced in aquatic organisms by this pollutant, namely in invertebrate species. Diopatra neapolitana and Hediste diversicolor are keystone polychaete species inhabiting estuaries and shallow water bodies intertidal mudflats, frequently used to evaluate the impact of environmental disturbances in these systems...
January 4, 2017: Environmental Research
https://www.readbyqxmd.com/read/28057432/pattern-of-cognitive-impairment-in-patients-with-parkinson-s-disease-and-psychosis-a-critical-review
#12
REVIEW
Abhishek Lenka, Shantala Hegde, Shyam Sundar Arumugham, Pramod Kumar Pal
Psychosis is one of the debilitating non-motor symptoms (NMS) of Parkinson's disease (PD). Cognitive impairment is considered to be a risk factor for emergence of psychosis in PD. Early detection of relevant cognitive impairment may serve as a predictor for development of psychosis, with implications for prevention and early intervention. However, the exact pattern of cognitive impairment associated with psychosis is not clear. In this article, we aim to critically review the literature on case-control studies in PD patients with and without psychosis in order to understand the pattern of cognitive impairment in those with psychosis...
December 29, 2016: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28055265/nanomaterial-induced-cell-death-in-pulmonary-and-hepatic-cells-following-exposure-to-three-different-metallic-materials-the-role-of-autophagy-and-apoptosis
#13
Ali Kermanizadeh, Kim Jantzen, Michael B Ward, Jon Ambæk Durhuus, Lene Juel Rasmussen, Steffen Loft, Peter Møller
Autophagy is the catabolic process involving the sequestration of the cytoplasm within double-membrane vesicles, which fuse with lysosomes to form autolysosomes in which autophagic targets are degraded. Since most endocytic routes of nanomaterial uptake converge upon the lysosome and the possibility that autophagy induction by NMs may be an attempt by the cell to self-preserve following the external challenge, this study investigated the role of autophagy following exposure to a panel of widely used metal-based NMs with high toxicity (Ag and ZnO) or low toxicity (TiO2) in a pulmonary (A549) and hepatic (HepG2) cell line...
January 5, 2017: Nanotoxicology
https://www.readbyqxmd.com/read/28052078/morphological-characterization-of-a-new-and-easily-recognizable-nuclear-male-sterile-mutant-of-sorghum-sorghum-bicolor
#14
Zhanguo Xin, Jian Huang, Ashley R Smith, Junping Chen, John Burke, Scott E Sattler, Dazhong Zhao
Sorghum (Sorghum bicolor L. Moench) is one of the most important grain crops in the world. The nuclear male sterility (NMS) trait, which is caused by mutations on the nuclear gene, is valuable for hybrid breeding and genetic studies. Several NMS mutants have been reported previously, but none of them were well characterized. Here, we present our detailed morphological characterization of a new and easily recognizable NMS sorghum mutant male sterile 8 (ms8) isolated from an elite inbred BTx623 mutagenized by ethyl methane sulfonate (EMS)...
2017: PloS One
https://www.readbyqxmd.com/read/28048278/we-fg-206-03-an-adaptive-model-for-pharmacokinetic-nested-model-selection-in-dynamic-contrast-enhanced-mri-data-analysis
#15
H Bagher-Ebadian, M Mohammadian Behbahani, J Ewing
PURPOSE: This study introduces an adaptive Model Selection (MS) technique to perform Pharmacokinetic nested MS from the time trace of longitudinal relaxation rate change, ΔR1 (R1 = 1/T1) in Dynamic Contrast Enhanced (DCE) MRI studies. METHODS: Three physiologically nested models derived from the standard Tofts model along with an averaged (over 30 patients) arterial input function were used to simulate a set of ΔR1 profiles to describe possible physiological conditions of underlying tissue pathology: Model-1: the vascular compartment is filled with contrast agent (CA) with no outward leakage...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048158/su-f-i-26-maximum-likelihood-and-nested-model-selection-techniques-for-pharmacokinetic-analysis-of-dynamic-contrast-enhanced-mri-in-patients-with-glioblastoma-tumors
#16
H Bagher-Ebadian, A Dehkordi, J Ewing
PURPOSE: This pilot study introduces a novel approach for estimation of pharmacokinetic parameters in dynamic contrast enhanced magnetic resonance imaging (DCE-MRI). In this study Maximum Likelihood (ML) and Nested Model Selection (NMS) techniques are combined to construct an approximately unbiased estimator for DCE-MRI data analysis. METHODS: DCE T1-weighted MRI using the contrast agent (CA) gadopentetate dimeglumine was performed on 20 patients with Glioblastoma tumor...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045840/acute-dystonia-versus-neuroleptic-malignant-syndrome-without-fever-in-an-eight-year-old-child
#17
Rita Sridaran, Chadd E Nesbit
Neuroleptic malignant syndrome (NMS) is a rare but potentially fatal complication of the use of certain medications. It is being seen more often in the pediatric population because of the increasing use of both typical and atypical antipsychotics in children. Rapid recognition of NMS is important to emergency physicians because timely treatment can be life saving. Acute dystonia is also a well-known and more common adverse effect of certain types of antipsychotics, more commonly seen with the typical antipsychotics versus the atypical antipsychotics...
January 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28043672/the-changes-of-electrolytes-in-serum-and-urine-in-children-with-neurally-mediated-syncope-cured-by-oral-rehydration-salts
#18
Wenhua Zhang, Runmei Zou, Lijia Wu, Xuemei Luo, Yi Xu, Fang Li, Ping Lin, Zhenwu Xie, Cheng Wang
OBJECTIVE: To detect the changes of electrolytes in serum and urine in children with nerve mediated syncope (NMS) cured by oral rehydration salts (ORS). METHOD: From May 2014 to April 2015, 135 patients with symptoms like unexplained syncope and presyncope were administrated in our hospital, including 60 boys and 75 girls, aged between 4 and 16 (10.2±2.7) years. After head-up tilt test (HUTT), their electrolytes in serum and urine were examined. Those who were positive to the HUTT received ORS and health education, while others were only treated by health education...
December 28, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28042337/improved-tumor-uptake-by-optimizing-liposome-based-res-blockade-strategy
#19
Xiaolian Sun, Xuefeng Yan, Orit Jacobson, Wenjing Sun, Zhantong Wang, Xiao Tong, Yuqiong Xia, Daishun Ling, Xiaoyuan Chen
Minimizing the sequestration of nanomaterials (NMs) by the reticuloendothelial system (RES) can enhance the circulation time of NMs, and thus increase their tumor-specific accumulation. Liposomes are generally regarded as safe (GRAS) agents that can block the RES reversibly and temporarily. With the help of positron emission tomography (PET), we monitored the in vivo tissue distribution of (64)Cu-labeled 40 × 10 nm gold nanorods (Au NRs) after pretreatment with liposomes. We systematically studied the effectiveness of liposome administration by comparing (1) differently charged liposomes; (2) different liposome doses; and (3) varying time intervals between liposome dose and NR dose...
2017: Theranostics
https://www.readbyqxmd.com/read/28029554/validation-of-the-italian-version-of-the-non-motor-symptoms-scale-for-parkinson-s-disease
#20
I Cova, M E Di Battista, N Vanacore, C P Papi, G Alampi, A Rubino, M Valente, G Meco, P Contri, A Di Pucchio, E Lacorte, A Priori, C Mariani, S Pomati
OBJECTIVE: To validate the adapted Italian version of the Non-Motor Symptoms Scale (NMSS), a tool to assess non-motor symptoms (NMS) in Parkinson's disease (PD). METHODS: A cross cultural adaptation of the NMSS into Italian and a psychometric analysis of the translated version of the NMSS was carried out in patients with PD from two university centres-affiliated hospitals. The quality of data and the acceptability, reliability and construct validity of NMSS were analyzed...
January 2017: Parkinsonism & related Disorders
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