Luis Moral, Teresa Toral, Candelaria Muñoz, Nuria Marco, Belén García-Avilés, Laura Murcia, María José Forniés, María Cristina González, Francisco Canals, Esther Bragado, Javier Martínez Olmos, Carlos García-Magán, José Domingo Moure González, Nuria Cortés, Magalí Giménez, Catalina Gómez, Ana Belén Rodríguez, Ana Moreno, José Manuel Lucas, Sergio Quevedo, Cristina Blasco, Yolanda Aliaga
BACKGROUND: Allergy to beta-lactam antibiotics (BLA) is frequently suspected in children, but a drug provocation test (DPT) rules it out in over 90% of cases. Direct oral DPT (DODPT), without skin or other previous tests, is increasingly been used to delabel non-immediate BLA reactions. This real-world study aimed to assess the safety and effectiveness of DODPT in children with immediate and non-immediate reactions to BLAs. METHODS: Ambispective registry study in children (<15 years), attended between 2016 and 2023 for suspected BLA allergy in 15 hospitals in Spain that routinely perform DODPT...
March 2024: Pediatric Allergy and Immunology