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https://www.readbyqxmd.com/read/28094079/a-stroke-mimic-methotrexate-induced-neurotoxicity-in-the-emergency-department
#1
Patrick Rogers, Wilbur J Pan, Richard A Drachtman, Christopher Haines
BACKGROUND: Acute lymphoblastic leukemia (ALL) is the most common form of childhood leukemia. The treatment of ALL involves multimodality therapy, and methotrexate (MTX) remains a mainstay of treatment. A complication of MTX therapy includes acute, subacute, and chronic neurotoxocity. Signs and symptoms may range from headaches, dizziness, and mood disorders to seizures and stroke-like symptoms. CASE REPORT: An 18-year-old woman with a history of ALL presented to the emergency department with acute onset of right-sided facial paralysis, right upper extremity flaccid paralysis, and right lower extremity weakness after receiving MTX therapy 3 days earlier...
January 13, 2017: Journal of Emergency Medicine
https://www.readbyqxmd.com/read/28027810/first-in-human-safety-and-immunogenicity-investigations-of-three-adjuvanted-reduced-dose-inactivated-poliovirus-vaccines-ipv-al-ssi-compared-to-full-dose-ipv-vaccine-ssi-when-given-as-a-booster-vaccination-to-adolescents-with-a-history-of-ipv-vaccination-at
#2
Line M Lindgren, Pernille N Tingskov, Annette H Justesen, Bettina S Nedergaard, Klaus J Olsen, Lars V Andreasen, Ingrid Kromann, Charlotte Sørensen, Jes Dietrich, Birgit Thierry-Carstensen
BACKGROUND: There is a demand of affordable IPV in the World. Statens Serum Institut (SSI) has developed three reduced dose IPV formulations adsorbed to aluminium hydroxide; 1/3 IPV-Al, 1/5 IPV-Al and 1/10 IPV-Al SSI, and now report the results of the first investigations in humans. METHODS: 240 Danish adolescents, aged 10-15years, and childhood vaccinated with IPV were booster vaccinated with 1/3 IPV-Al, 1/5 IPV-Al, 1/10 IPV-Al or IPV Vaccine SSI. The booster effects (GMTRs) of the three IPV-Al SSI were compared to IPV Vaccine SSI, and evaluated for non-inferiority...
December 24, 2016: Vaccine
https://www.readbyqxmd.com/read/27994838/reversible-cerebral-vasoconstriction-syndrome-promptly-diagnosed-with-magnetic-resonance-imaging-including-magnetic-resonance-angiography-during-immunosuppressive-therapy-in-a-16-year-old-girl-with-refractory-cytopenia-of-childhood
#3
Hideaki Ueki, Yasushi Sanayama, Akiyo Miyajima, Taichiro Tsuchimochi, Shunji Igarashi, Shosuke Sunami
Reversible cerebral vasoconstriction syndrome (RCVS) is a syndrome characterized by severe headache with segmental vasoconstriction of the cerebral arteries that resolves within 12 weeks. A 16-year-old girl with refractory cytopenia of childhood, who was receiving the immunosuppressant cyclosporine, developed severe headache and was diagnosed with RCVS using magnetic resonance imaging, including magnetic resonance angiography (MRA). MRA is a non-invasive and very effective technique for diagnosing RCVS. MRA should be performed at the onset of severe headache during immunosuppressant administration for children with hematological disorders and may prevent sequelae such as posterior reversible encephalopathy syndrome or ischemic attack...
November 2, 2016: Hematology Reports
https://www.readbyqxmd.com/read/27993427/reconsideration-of-the-diagnosis-and-treatment-of-childhood-migraine-a-practical-review-of-clinical-experiences
#4
Yoshiaki Saito, Gaku Yamanaka, Hideki Shimomura, Kazuhiro Shiraishi, Tomoyuki Nakazawa, Fumihide Kato, Yuko Shimizu-Motohashi, Masayuki Sasaki, Yoshihiro Maegaki
OBJECTIVE: To provide insight into the wide spectrum of migraine during childhood to establish practical and comprehensive treatment strategies. BACKGROUND: Although recent studies have confirmed the effect of anti-migraine agents in childhood headaches fulfilling the criteria of migraine without aura, there have been no studies regarding the efficacy of these drugs in childhood migraine without aura not filling the diagnostic criteria. METHODS: In total, 154 patients with a clinical diagnosis of migraine, with onset of repetitive headaches at the age of ⩽15years, were retrospectively included from clinics in seven tertiary medical centers...
December 16, 2016: Brain & Development
https://www.readbyqxmd.com/read/27951626/diagnostic-role-of-mean-platelet-volume-and-neutrophil-to-lymphocyte-ratio-in-childhood-brucellosis
#5
Şefika Elmas Bozdemir, Yasemin Ay Altıntop, Salih Uytun, Humeyra Aslaner, Yasemin Altuner Torun
Background/Aims: Brucellosis patients present various non-specific clinical symptoms, such as fever, fatigue, sweating, joint pain, arthritis, myalgia, and headache. Based on the nonspecifity of its clinical signs and symtoms, we decided to evaluate whether mean platelet volume (MPV) , neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR) will contribute to the diagnosis. Methods: In this retrospective study, we reviewed hospital-records of 60 children with a confirmed diagnosis of brucellosis in Kayseri between January 2013 and January 2016, and compared the hematological parameters; white blood cell (WBC) count, hemoglobin (Hb), neutrophil count, lymphocyte count, platelet count, MPV, NLR, and PLR with 55 healthy age and gender matched children...
December 14, 2016: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/27918236/meniere-s-migraine-and-motion-sickness
#6
John F Golding, Mitesh Patel
CONCLUSION: Elevated Motion Sickness Susceptibility (MSS) in Meniere?s disease (MD) is likely to be a consequence of the onset of MD and not migraine per se. OBJECTIVES: Pathologies of the vestibular system influence MSS. Bilateral vestibular deficits lower MSS, vestibular neuritis or benign paroxysmal positional vertigo have little overall effect, whereas vestibular migraine elevates MSS. However, less is known about MSS in MD, a condition in which many patients experience vestibular loss and migraine symptoms...
December 5, 2016: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/27917478/emotional-abuse-history-and-migraine-among-young-adults-a-retrospective-cross-sectional-analysis-of-the-add-health-dataset
#7
Gretchen E Tietjen, Monita Karmakar, Aliaksandr A Amialchuk
OBJECTIVES: To define and examine the relationship between self-reported childhood abuse and migraine among young adults. BACKGROUND: Headache and migraine have been linked to childhood abuse in numerous studies, but there is incomplete characterization of headache types, and limited assessment of abuse types and frequency. Only one population-based study has examined the relationship between emotional abuse and migraine. None have investigated the temporal relationship between onset of abuse and of migraine...
January 2017: Headache
https://www.readbyqxmd.com/read/27873123/vestibular-migraine-in-children-and-adolescents
#8
REVIEW
Thyra Langhagen, Mirjam N Landgraf, Doreen Huppert, Florian Heinen, Klaus Jahn
PURPOSE OF REVIEW: The goal of this review is to provide an actualized overview on vestibular migraine in childhood and adolescence, with focus on the epidemiology and clinical presentation as well as its treatment. RECENT FINDINGS: Vertigo spells in childhood can evolve into other periodic syndromes and/or migraine types and persist even into adulthood. Vestibular migraine (VM) and benign paroxysmal vertigo are the most common causes of vertigo in children and adolescents...
December 2016: Current Pain and Headache Reports
https://www.readbyqxmd.com/read/27857798/not-all-cases-of-nyctalopia-are-benign-unusual-and-serendipitous-presentation-of-arnold-chiari-type-1-malformation-at-a-pediatric-tertiary-care-center
#9
Kailash Chandra Patra, Abhijeet Prakash Kirtane
The Arnold-Chiari Type 1 malformation (CM1) is a rare congenital abnormality characterized by ectopia or caudal herniation of the cerebellar tonsils through the foramen magnum into the cervical spine, resulting in crowding at the craniocervical junction. It seldom presents in childhood with symptoms and a normal neurological examination. More typically, CM1 presents in young adult women with neurological symptoms including a headache, cervical pain, cranial nerve palsies, neurosensory deficit, and ataxia. Ocular manifestations associated with Chiari I include third and sixth cranial nerve paresis and convergence/divergence abnormalities...
July 2016: Journal of Pediatric Neurosciences
https://www.readbyqxmd.com/read/27856122/evaluation-of-a-follow-up-program-for-mild-traumatic-brain-injury-in-schoolchildren
#10
R Nowacki, N van Eldik, M Eikens, R Roijen, N Haga, D Schott, T Simons-Sporken, M Wennekes
INTRODUCTION: Mild traumatic brain injury is a common condition in childhood. Although classified as mild, post-concussive symptoms may persist and interfere with daily activities. Because no established guidelines exist with respect to follow-up medical care for these children, there may be a delay in receiving appropriate care. We developed a follow up program to screen for persistent symptoms and if necessary, refer patients for further medical assistance. METHODS: From July 2010 until December 2013, eligible children aged 4-18 years who presented after sustaining a mild traumatic brain injury were included...
November 2, 2016: European Journal of Paediatric Neurology: EJPN
https://www.readbyqxmd.com/read/27832898/a-32-year-old-man-with-a-severe-headache-visual-loss-and-nodular-pulmonary-opacities
#11
Valliappan Muthu, Inderpaul Singh Sehgal, Ritesh Agarwal, Sahajal Dhooria
A 32-year-old man presented with severe headache, vomiting, and painless loss of vision of 5 days' duration. He had no seizures, other neurologic deficits, or fever. Two months prior to presentation, he had an episode of hemoptysis of 30 to 50 mL, which resolved spontaneously; there was no recurrence. He reported one to two episodes of epistaxis each month that resolved spontaneously, since childhood. He had no known comorbid illness, prior surgeries, dental procedures, or blood transfusions. He denied any history of substance abuse...
November 2016: Chest
https://www.readbyqxmd.com/read/27818813/familial-hemiplegic-migraine-with-severe-attacks-a-new-report-with-atp1a2-mutation
#12
E Martínez, R Moreno, L López-Mesonero, I Vidriales, M Ruiz, A L Guerrero, J J Tellería
Introduction. Familial hemiplegic migraine (FHM) is a rare disorder characterized by migraine attacks with motor weakness during the aura phase. Mutations in CACNA1A, ATP1A2, SCN1A, and PRRT2 genes have been described. Methods. To describe a mutation in ATP1A2 gene in a FHM case with especially severe and prolonged symptomatology. Results. 22-year-old woman was admitted due to migraine-type headache and sudden onset of right-sided weakness and aphasia; she had similar episodes in her childhood. Her mother was diagnosed with hemiplegic migraine without genetic confirmation...
2016: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/27813651/a-systematic-review-of-the-use-of-bupropion-for-attention-deficit-hyperactivity-disorder-in-children-and-adolescents
#13
Qin Xiang Ng
INTRODUCTION: Attention-deficit/hyperactivity disorder (ADHD) is one of the most prevalent neuropsychiatric disorders of childhood and adolescence. Stimulants are usually the first choice of drug; however, as many as 20% of patients do not respond to them. Stimulants may also worsen comorbid sleep, mood, and anxiety disorders, and they are associated with problems of misuse and diversion. Bupropion, a dopamine and norepinephrine reuptake inhibitor, is a promising nonstimulant alternative with reports of positive outcomes for ADHD management in both adolescent and adult populations...
November 4, 2016: Journal of Child and Adolescent Psychopharmacology
https://www.readbyqxmd.com/read/27788026/trial-of-amitriptyline-topiramate-and-placebo-for-pediatric-migraine
#14
Scott W Powers, Christopher S Coffey, Leigh A Chamberlin, Dixie J Ecklund, Elizabeth A Klingner, Jon W Yankey, Leslie L Korbee, Linda L Porter, Andrew D Hershey
Background Which, medication, if any, to use to prevent the headache of pediatric migraine has not been established. Methods We conducted a randomized, double-blind, placebo-controlled trial of amitriptyline (1 mg per kilogram of body weight per day), topiramate (2 mg per kilogram per day), and placebo in children and adolescents 8 to 17 years of age with migraine. Patients were randomly assigned in a 2:2:1 ratio to receive one of the medications or placebo. The primary outcome was a relative reduction of 50% or more in the number of headache days in the comparison of the 28-day baseline period with the last 28 days of a 24-week trial...
12, 2017: New England Journal of Medicine
https://www.readbyqxmd.com/read/27787649/acute-hemicerebellitis-in-a-child-a-case-report-of-a-rare-neuropsychiatric-disorder
#15
Riad M Elsayed, Hala E Sayyah
BACKGROUND: Acute cerebellitis is an inflammatory process commonly involving both cerebellar hemispheres. Bilateral cerebellar hemisphere involvement is the most common finding. Acute hemicerebellitis in childhood is an extremely rare unilateral presentation of cerebellitis mimicking a tumor. Its etiology is unknown, although an inflammatory or post infectious origin is presumed. Its clinical outcome is generally good and a self-limited evolution. Clinical improvement and regression of the pathological findings in serial MRI will help differentiate acute hemicerebellitis from a neoplastic process...
October 27, 2016: Child's Nervous System: ChNS: Official Journal of the International Society for Pediatric Neurosurgery
https://www.readbyqxmd.com/read/27779347/the-effect-of-general-anesthesia-for-ambulatory-dental-treatment-on-children-in-chongqing-southwest-china
#16
Zhang Chao, Huang Gui Jin, Yu Cong
BACKGROUND: The incidence of early childhood caries shows a significant increasing trend. Often, children younger than 6 years need additional help to finish the dental treatment. Therefore, general anesthesia (GA) could help to provide a successful environment for pediatric dental treatment. OBJECTIVES: The aim of this study was to assess the effect of dental treatment under general anesthesia (DGA) on the patients' oral health in Chongqing, Southwest China using the P-CPQ and the FIS questionnaires...
January 2017: Paediatric Anaesthesia
https://www.readbyqxmd.com/read/27770403/characterising-the-premonitory-stage-of-migraine-in-children-a-clinic-based-study-of-100-patients-in-a-specialist-headache-service
#17
N Karsan, P Prabhakar, P J Goadsby
BACKGROUND: The premonitory stage of migraine attacks, when symptomatology outside of pain can manifest hours to days before the onset of the headache, is well recognised. Such symptoms have been reported in adults in a number of studies, and have value in predicting an impending headache. These symptoms have not been extensively studied in children. We aimed to characterise which, if any, of these symptoms are reported in children seen within a Specialist Headache Service. METHODS: We reviewed clinic letters from the initial consultation of children and adolescents seen within the Specialist Headache Service at Great Ormond Street Hospital between 1999 and 2015 with migraine in whom we had prospectively assessed clinical phenotype data...
December 2016: Journal of Headache and Pain
https://www.readbyqxmd.com/read/27749807/presentation-of-acute-childhood-stroke-in-a-tertiary-pediatric-emergency-department
#18
Adriana Yock-Corrales, Flory Varela-Bulgarelli, Cary Barboza, Alfonso Gutierrez-Mata, Mark T Mackay, Franz Babl
OBJECTIVES: The aim was to describe clinical presentation, management, and outcomes of stroke in a tertiary emergency department (ED) of a developing country. METHODOLOGY: Retrospective case series of patients aged 1 month to 18 years presenting to an ED with radiological confirmed acute stroke during a 7-year period were studied. RESULTS: Ninety-five patients were identified. Twenty-five patients were excluded because of incomplete records (8) or not presenting via ED (17)...
October 4, 2016: Pediatric Emergency Care
https://www.readbyqxmd.com/read/27704257/diagnosis-and-treatment-of-childhood-migraine
#19
Kelsey Merison, Howard Jacobs
While the diagnosis of migraine in children is generally straightforward, treatment can seem complex with a number of medication choices, many of which are used "off label." Patients with intermittent migraines can often be managed with ibuprofen or naproxen taken as needed. Unfortunately, by the time that children present to our practice, they have often tried these medications without improvement. Triptans are frequently prescribed to these patients with good success. It is important to make the patient aware of the possible associated serotonergic reactions...
November 2016: Current Treatment Options in Neurology
https://www.readbyqxmd.com/read/27701747/oral-appliances-and-functional-orthopaedic-appliances-for-obstructive-sleep-apnoea-in-children
#20
REVIEW
Fernando R Carvalho, Débora A Lentini-Oliveira, Lucila Bf Prado, Gilmar F Prado, Luciane Bc Carvalho
BACKGROUND: Apnoea is a breathing disorder marked by the absence of airflow at the nose or mouth. In children, risk factors include adenotonsillar hypertrophy, obesity, neuromuscular disorders and craniofacial anomalies. The most common treatment for obstructive sleep apnoea syndrome (OSAS) in childhood is adeno-tonsillectomy. This approach is limited by its surgical risks, mostly in children with comorbidities and, in some patients, by recurrence that can be associated with craniofacial problems...
October 5, 2016: Cochrane Database of Systematic Reviews
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