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Childhood stroke

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https://www.readbyqxmd.com/read/28808172/child-neurology-childhood-basilar-artery-occlusion-and-stroke
#1
Mina Lobbous, Sara Williams, Salman Rashid
No abstract text is available yet for this article.
August 15, 2017: Neurology
https://www.readbyqxmd.com/read/28805445/prevalence-and-predictors-of-learning-and-psychological-diagnoses-following-pediatric-arterial-ischemic-stroke
#2
Tricia S Williams, Kyla P McDonald, Samantha D Roberts, Nomazulu Dlamini, Gabrielle deVeber, Robyn Westmacott
This study examined the prevalence of learning and psychological diagnoses and associated neurological and personal-environmental risk factors following perinatal and childhood arterial ischemic stroke. In our sample of 126 children and youth, 52.4% received a diagnosis following their assessment. Specifically, 32% had a single diagnosis and 21% had two or more diagnoses. Learning disability, attention deficit-hyperactivity disorder, and intellectual disability were the most prevalent diagnoses. Associated risk factors varied by diagnosis with lower intellectual functioning being the common risk factor across categories...
August 14, 2017: Developmental Neuropsychology
https://www.readbyqxmd.com/read/28803513/mechanisms-of-unexpected-death-and-autopsy-findings-in-friedreich-ataxia
#3
Roger W Byard, John D Gilbert
A 36-year-old woman with a clinical history of Friedreich ataxia and hypertrophic cardiomyopathy was found unexpectedly dead at her home. The heart showed asymmetric left ventricular hypertrophy, with an interventricular septal thickness of 20-25 mm (the remainder of the left ventricular wall measured 15 mm). Histologically, both ventricles had irregular areas of marked myocyte hypertrophy with associated interstitial fibrosis and focal myofibre disarray. There was neuronal loss within the dentate nucleus of the cerebellum, with vacuolation and axonal loss in the dorsal columns and spinocerebellar tracts of the upper cervical spinal cord...
January 1, 2017: Medicine, Science, and the Law
https://www.readbyqxmd.com/read/28798906/cerebral-sinovenous-thrombosis
#4
REVIEW
Rebecca Ichord
Cerebral sinovenous thrombosis (CSVT) is a rare but serious cerebrovascular disorder affecting children from the newborn period through childhood and adolescence. The incidence is estimated at 0.6/100,000/year, with 30-50% occurring in newborns. Causes are diverse and are highly age dependent. Acute systemic illness is the dominant risk factor among newborns. In childhood CSVT, acute infections of the head and neck such as mastoiditis are most common, followed by chronic underlying diseases such as nephrotic syndrome, cancer, and inflammatory bowel disease...
2017: Frontiers in Pediatrics
https://www.readbyqxmd.com/read/28798024/fabry-disease-in-families-with-hypertrophic-cardiomyopathy-clinical-manifestations-in-the-classic-and-later-onset-phenotypes
#5
Berglind Adalsteinsdottir, Runolfur Palsson, Robert J Desnick, Marianna Gardarsdottir, Polakit Teekakirikul, Martin Maron, Evan Appelbaum, Ulf Neisius, Barry J Maron, Michael A Burke, Brenden Chen, Silvere Pagant, Christoffer V Madsen, Ragnar Danielsen, Reynir Arngrimsson, Ulla Feldt-Rasmussen, Jonathan G Seidman, Christine E Seidman, Gunnar Th Gunnarsson
BACKGROUND: The screening of Icelandic patients clinically diagnosed with hypertrophic cardiomyopathy resulted in identification of 8 individuals from 2 families with X-linked Fabry disease (FD) caused by GLA(α-galactosidase A gene) mutations encoding p.D322E (family A) or p.I232T (family B). METHODS AND RESULTS: Familial screening of at-risk relatives identified mutations in 16 family A members (8 men and 8 heterozygotes) and 25 family B members (10 men and 15 heterozygotes)...
August 2017: Circulation. Cardiovascular Genetics
https://www.readbyqxmd.com/read/28764553/severe-infections-and-subsequent-delayed-cardiovascular-disease
#6
Cecilia Bergh, Katja Fall, Ruzan Udumyan, Hugo Sjöqvist, Ole Fröbert, Scott Montgomery
Background Severe infections in adulthood are associated with subsequent short-term cardiovascular disease. Whether hospital admission for sepsis or pneumonia is associated with persistent increased risk (over a year after infection) is less well established. Design The design of this study was as a register-based cohort study. Methods Some 236,739 men born between 1952-1956 were followed from conscription assessments in adolescence to 2010. All-cause cardiovascular disease ( n = 46,754), including coronary heart disease ( n = 10,279) and stroke ( n = 3438), was identified through national registers 1970-2010 (at ages 18-58 years)...
January 1, 2017: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/28756061/assessment-of-acute-motor-deficit-in-the-pediatric-emergency-room
#7
REVIEW
Marcio Moacyr Vasconcelos, Luciana G A Vasconcelos, Adriana Rocha Brito
OBJECTIVES: This review article aimed to present a clinical approach, emphasizing the diagnostic investigation, to children and adolescents who present in the emergency room with acute-onset muscle weakness. SOURCES: A systematic search was performed in PubMed database during April and May 2017, using the following search terms in various combinations: "acute," "weakness," "motor deficit," "flaccid paralysis," "child," "pediatric," and "emergency". The articles chosen for this review were published over the past ten years, from 1997 through 2017...
July 27, 2017: Jornal de Pediatria
https://www.readbyqxmd.com/read/28742875/the-significance-of-inadequate-transcranial-doppler-studies-in-children-with-sickle-cell-disease
#8
Simon Greenwood, Colin Deane, Oliver L Rees, Ben Freedman, Suresh Kumar, Naser Ben Ramadan, Sarah Wilkinson, Grant Marais, Julie Lord, Subarna Chakravorty, Susan E Height, Kate Gardner, David C Rees
Sickle cell disease (SCD) is a common cause of cerebrovascular disease in childhood. Primary stroke prevention is effective using transcranial Doppler (TCD) scans to measure intracranial blood velocities, and regular blood transfusions or hydroxycarbamide when these are abnormal. Inadequate TCD scans occur when it is not possible to measure velocities in all the main arteries. We have investigated the prevalence and significance of this in a retrospective audit of 3915 TCD scans in 1191 children, performed between 2008 and 2015...
2017: PloS One
https://www.readbyqxmd.com/read/28733481/focal-cerebral-arteriopathy-do-steroids-improve-outcome
#9
Maja Steinlin, Sandra Bigi, Belinda Stojanovski, Jay Gajera, Maria Regényi, Marwan El-Koussy, Mark T Mackay
BACKGROUND AND PURPOSE: Focal cerebral arteriopathy accounts for up to 35% of arterial ischemic stroke (AIS) in children and is the most important predictor of stroke recurrence. The study objective was to compare outcomes for children with focal cerebral arteriopathy treated with combined corticosteroid antithrombotic treatment (CAT) to those receiving antithrombotic treatment (AT) alone. METHODS: This multicenter retrospective Swiss/Australian cohort study analyzed consecutive children, aged 1 month to 18 years, presenting with first AIS because of a focal cerebral arteriopathy from 2000 to 2014...
July 21, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28731930/early-life-exposure-to-chinese-famine-modifies-the-association-between-hypertension-and-cardiovascular-disease
#10
Zumin Shi, Stephen J Nicholls, Anne W Taylor, Dianna J Magliano, Sarah Appleton, Paul Zimmet
OBJECTIVE: Studies have shown that famine exposure during early life may increase the risk of cardiovascular disease (CVD), hypertension, and diabetes during adulthood. We aimed to assess whether exposure to the Chinese famine (1959-1961) modifies the association between hypertension and CVD. METHODS: We investigated data of 5772 adults born between 1954 and 1964 from the China Health and Retirement Longitudinal Study. CVD was based on self-reported doctor's diagnosis of heart problems (heart attack, coronary heart disease, angina, congestive heart failure, or other heart problems) and stroke...
July 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28721760/stroke-in-childhood
#11
Lynne Pearce
Essential facts About 400 children a year have a stroke in the UK. Many are left with severe disability. While there have been improvements in diagnosis and treatment in recent years, the condition is still not as well recognised as stroke in adults. Experts believe that greater awareness among parents and healthcare professionals could lead to speedier diagnosis and minimise risk of severe long-term health problems.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28721757/higher-childhood-intelligence-linked-to-longer-life
#12
(no author information available yet)
Higher intelligence in childhood is associated with lower lifetime risk of major causes of death, including heart disease, stroke, smoking-related cancers, respiratory disease and dementia.
July 19, 2017: Nursing Standard
https://www.readbyqxmd.com/read/28706112/workup-for-perinatal-stroke-does-not-predict-recurrence
#13
Laura L Lehman, Jeanette Beaute, Kush Kapur, Amy R Danehy, Miya E Bernson-Leung, Hayley Malkin, Michael J Rivkin, Cameron C Trenor
BACKGROUND AND PURPOSE: Perinatal stroke, including neonatal and presumed perinatal presentation, represents the age in childhood in which stroke occurs most frequently. The roles of thrombophilia, arteriopathy, and cardiac anomalies in perinatal ischemic stroke are currently unclear. We took a uniform approach to perinatal ischemic stroke evaluation to study these risk factors and their association with recurrent stroke. METHODS: We reviewed records of perinatal stroke patients evaluated from August 2008 to February 2016 at a single referral center...
July 13, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28701080/neurocognitive-outcomes-in-children-with-unilateral-basal-ganglia-arterial-ischemic-stroke-and-secondary-hemidystonia
#14
Robyn Westmacott, Kyla P McDonald, Gabrielle deVeber, Daune MacGregor, Mahendranath Moharir, Nomazulu Dlamini, Rand Askalan, Tricia S Williams
Dystonia is a movement disorder that involves excessive, involuntary muscle contractions resulting in repetitive movements and/or abnormal posturing. One common cause of unilateral dystonia in childhood is ischemic stroke involving the basal ganglia and/or thalamus. Virtually nothing is known about neuropsychological outcomes in children who have dystonia following basal ganglia stroke. The present study explored whether or not children with secondary dystonia experience additional cognitive challenges when compared to children with similar patterns of brain injury, but no dystonia...
July 12, 2017: Child Neuropsychology: a Journal on Normal and Abnormal Development in Childhood and Adolescence
https://www.readbyqxmd.com/read/28691633/childhood-stroke
#15
Erin Dean
Essential facts [Figure: see text] Around 400 children in the UK have a stroke each year, leaving many with severe physical and mental impairments. Many professionals and parents can mistakenly think that strokes only affect older people, leading to delays in diagnosis and prompt treatment. Children may need long-term support including physiotherapy, speech and language therapy and support with education.
July 10, 2017: Nursing Children and Young People
https://www.readbyqxmd.com/read/28679853/predicting-progression-of-intracranial-arteriopathies-in-childhood-stroke-with-vessel-wall-imaging
#16
Nicholas V Stence, Lisa L Pabst, Amanda L Hollatz, David M Mirsky, Paco S Herson, Sharon Poisson, Richard J Traystman, Timothy J Bernard
BACKGROUND AND PURPOSE: Childhood arterial ischemic stroke is frequently associated with an intracranial arteriopathy that often progresses in the first 3 to 6 months post-stroke. We hypothesized that children with enhancing arteriopathies on vessel wall imaging (VWI) would have a higher risk of arteriopathy progression than those without enhancement. METHODS: Our institutional radiographic database was searched for cases of childhood stroke with VWI. Inclusion criteria consisted of age ranging from 1 month through 20 years, diagnosis of arterial ischemic stroke, available VWI, and follow-up magnetic resonance angiogram...
July 5, 2017: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/28660486/hutchinson-gilford-progeria-syndrome-a-premature-aging-disease
#17
REVIEW
Muhammad Saad Ahmed, Sana Ikram, Nousheen Bibi, Asif Mir
Progeria is sporadic, very rare, autosomal dominant, deadly childhood disorder. It is one of the progeroid syndromes also known as Hutchinson-Gilford progeria syndrome (HGPS). Aging is a developmental process that begins with fertilization and ends up with death involving a lot of environmental and genetic factors. The disease firstly involves premature aging and then death from complications of atherosclerosis such as myocardial infarction, stroke, atherosclerosis, or heart failure. The lifespan of the patient is normally up to teen age or early twenties...
June 28, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28659423/bmi-increase-through-puberty-and-adolescence-is-associated-with-risk-of-adult-stroke
#18
Claes Ohlsson, Maria Bygdell, Arvid Sondén, Christina Jern, Annika Rosengren, Jenny M Kindblom
OBJECTIVE: To evaluate the contribution of prepubertal childhood body mass index (BMI) and BMI change through puberty and adolescence, 2 distinct developmental BMI parameters, for risk of adult stroke in men. METHODS: In this population-based study in Gothenburg, Sweden, men born in 1945-1961 with information on both childhood BMI at age 8 and BMI change through puberty and adolescence (BMI at age 20-BMI at age 8) were followed until December 2013 (n = 37,669). Information on stroke events was retrieved from high-quality national registers (918 first stroke events, 672 ischemic stroke events [IS], 207 intracerebral hemorrhage events [ICH])...
July 25, 2017: Neurology
https://www.readbyqxmd.com/read/28659274/childhood-intelligence-in-relation-to-major-causes-of-death-in-68-year-follow-up-prospective-population-study
#19
Catherine M Calvin, G David Batty, Geoff Der, Caroline E Brett, Adele Taylor, Alison Pattie, Iva Čukić, Ian J Deary
Objectives To examine the association between intelligence measured in childhood and leading causes of death in men and women over the life course.Design Prospective cohort study based on a whole population of participants born in Scotland in 1936 and linked to mortality data across 68 years of follow-up.Setting Scotland.Participants 33 536 men and 32 229 women who were participants in the Scottish Mental Survey of 1947 (SMS1947) and who could be linked to cause of death data up to December 2015.Main outcome measures Cause specific mortality, including from coronary heart disease, stroke, specific cancer types, respiratory disease, digestive disease, external causes, and dementia...
June 28, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28632465/psychosocial-outcome-and-quality-of-life-following-childhood-stroke-a-systematic-review
#20
Fiadhnait O'Keeffe, Daniel Stark, Orlagh Murphy, Vijeya Ganesan, John King, Tara Murphy
OBJECTIVES: The aim of this paper was to critically review the recent literature on psychosocial and behavioral outcome following childhood stroke, to assess whether quality of life is affected and to investigate the factors related to psychosocial outcome. METHODS: Literature searches were conducted and identified 36 relevant papers from the period 1908-2016. RESULTS: The systematic review found that many children experience difficulties in a wide range of psychosocial domains...
February 16, 2017: Developmental Neurorehabilitation
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