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Causal attribution

Casley Borges de Queiroz, Mateus Ferreira Santana, Pedro M Pereira Vidigal, Marisa Vieira de Queiroz
Fungi of the genus Colletotrichum are economically important and are used as models in plant-pathogen interaction studies. In this study, the complete mitochondrial genomes of two Colletotrichum lindemuthianum isolates were sequenced and compared with the mitochondrial genomes of seven species of Colletotrichum. The mitochondrial genome of C. lindemuthianum is a typical circular molecule 37,446 bp (isolate 89 A 2 2-3) and 37,440 bp (isolate 83.501) in length. The difference of six nucleotides between the two genomes is the result of a deletion in the ribosomal protein S3 (rps3) gene in the 83...
February 16, 2018: Applied Microbiology and Biotechnology
Hong-Yi Wang, Ning Wang, Zhen-Xing Chu, Jing Zhang, Xiang Mao, Wen-Qing Geng, Yong-Jun Jiang, Hong Shang, Jun-Jie Xu
Intimate partner violence (IPV) and HIV are highly prevalent worldwide among MSM. However, the association between IPV and HIV seroconversion is virtually unknown. This 12-month prospective cohort study was conducted among MSM in Shenyang, China to explore the causality between IPV and the incidence of HIV. Adjusted Hazard Ratios (aHRs) of HIV acquisition were derived from a multivariate time-dependent Cox model and applied to calculate population attributable fractions (PAFs). Among 476 HIV-negative MSM subjects, 89(18...
February 13, 2018: Scientific Reports
Ho Joong Kim, Saejong Park, Soo Hyun Park, Jiwon Park, Bong Soon Chang, Choon Ki Lee, Jin S Yeom
PURPOSE: To assess the association between frailty and osteoporotic vertebral compression fracture (OVCF) and to evaluate the relationship between numbers of OVCFs and frailty. MATERIALS AND METHODS: We enrolled 760 subjects, including 59 patients (with OVCF) and 701 controls (without OVCF). Successful matching provided 56 patient-control pairs. We analyzed principal clinical and demographic information, which included sex, age, height, weight, body mass index (BMI), variable frailty phenotypes, and Oswestry Disability Index (ODI) and EuroQol 5-dimension questionnaire (EQ-5D) scores...
March 2018: Yonsei Medical Journal
Nishtha Pandey, Tabassum Rashid, Rajeev Jalvi, Meenakshi Sharma, Raghunath Rangasayee, Khurshid Iqbal Andrabi, Anuranjan Anand
Background & objectives: A high incidence of hearing impairment is reported from the village of Dhadkai in the State of Jammu and Kashmir, India. Prevalence of endogamy in this community suggested a common genetic basis for the disorder. A genetic study was undertaken to ascertain the basis for the high incidence of hearing impairment in this region. Methods: In a two-step approach to identify the causative mutation/s, a whole-genome-based linkage analysis of an extended family of 45 members was carried out, which included 23 affected and 22 unaffected members...
October 2017: Indian Journal of Medical Research
Mengni Chen, Chris J Lloyd, Paul S F Yip
A country's total fertility rate (TFR) depends on many factors. Attributing changes in TFR to changes of policy is difficult, as they could easily be correlated with changes in the unmeasured drivers of TFR. A case in point is Australia where both pronatalist effort and TFR increased in lock step from 2001 to 2008 and then decreased. The global financial crisis or other unobserved confounders might explain both the reducing TFR and pronatalist incentives after 2008. Therefore, it is difficult to estimate causal effects of policy using econometric techniques...
2018: PloS One
Joaquim Alves da Silva, Fatuel Tecuapetla, Vitor Paixão, Rui M Costa
Deciding when and whether to move is critical for survival. Loss of dopamine neurons (DANs) of the substantia nigra pars compacta (SNc) in patients with Parkinson's disease causes deficits in movement initiation and slowness of movement. The role of DANs in self-paced movement has mostly been attributed to their tonic activity, whereas phasic changes in DAN activity have been linked to reward prediction. This model has recently been challenged by studies showing transient changes in DAN activity before or during self-paced movement initiation...
February 8, 2018: Nature
Piyal Karunarathne, Mara Schedler, Eric J Martínez, Ana I Honfi, Anastasiia Novichkova, Diego Hojsgaard
Background and Aims: Niche divergence between polyploids and their lower ploidy progenitors is one of the primary mechanisms fostering polyploid establishment and adaptive divergence. However, within-species chromosomal and reproductive variability have usually been neglected in community ecology and biodiversity analyses even though they have been recognized to play a role in the adaptive diversification of lineages. Methods: We used Paspalum intermedium, a grass species with diverging genetic systems (diploidy vs...
February 3, 2018: Annals of Botany
Susan Joiner, Emmanuel A Asante, Jacqueline M Linehan, Lara Brock, Sebastian Brandner, Susan J Bellworthy, Marion M Simmons, James Hope, John Collinge, Jonathan D F Wadsworth
The epizootic prion disease of cattle, bovine spongiform encephalopathy (BSE), causes variant Creutzfeldt-Jakob disease (vCJD) in humans following dietary exposure. While it is assumed that all cases of vCJD attributed to a dietary aetiology are related to cattle BSE, sheep and goats are susceptible to experimental oral challenge with cattle BSE prions and farmed animals in the UK were undoubtedly exposed to BSE-contaminated meat and bone meal during the late 1980s and early 1990s. Although no natural field cases of sheep BSE have been identified, it cannot be excluded that some BSE-infected sheep might have entered the European human food chain...
March 15, 2018: Journal of the Neurological Sciences
Melissa D Thye, Donna L Murdaugh, Rajesh K Kana
Evidence from cognitive and social neuroscience research suggests that Theory of Mind (ToM), the ability to attribute mental states to others, is mediated by a group of brain regions collectively known as the ToM network. Nevertheless, there is significant variability in the functional activation of regions within this network across tasks. The goal of the present functional magnetic resonance imaging (fMRI) study was to examine the common and differential neural mechanisms of two aspects of ToM processing (emotion/mental-state recognition and intentional attribution) using three distinct, but complementary ToM tasks (Reading the Mind in the Eyes (RMIE), Reading the Mind in the Voice (RMIV), and Intentional Causal Attribution) in healthy adults...
February 3, 2018: Neuroscience
Fabien Alcaraz, Virginie Fresno, Alain R Marchand, Eric J Kremer, Etienne Coutureau, Mathieu Wolff
Highly distributed neural circuits are thought to support adaptive decision-making in volatile and complex environments. Notably, the functional interactions between prefrontal and reciprocally connected thalamic nuclei areas may be important when choices are guided by current goal value or action-outcome contingency. We examined the functional involvement of selected thalamocortical and corticothalamic pathways connecting the dorsomedial prefrontal cortex (dmPFC) and the mediodorsal thalamus (MD) in the behaving rat...
February 6, 2018: ELife
Xiaolei Liu, Roi Treister, Magdalena Lang, Anne Louise Oaklander
Objectives: Small-fiber polyneuropathy (SFPN) has various underlying causes, including associations with systemic autoimmune conditions. We have proposed a new cause; small-fiber-targeting autoimmune diseases akin to Guillain-Barré and chronic inflammatory demyelinating polyneuropathy (CIDP). There are no treatment studies yet for this 'apparently autoimmune SFPN' (aaSFPN), but intravenous immunoglobulin (IVIg), first-line for Guillain-Barré and CIDP, is prescribed off-label for aaSFPN despite very high cost...
2018: Therapeutic Advances in Neurological Disorders
Michael Allon, Peter B Imrey, Alfred K Cheung, Milena Radeva, Charles E Alpers, Gerald J Beck, Laura M Dember, Alik Farber, Tom Greene, Jonathan Himmelfarb, Thomas S Huber, James S Kaufman, John W Kusek, Prabir Roy-Chaudhury, Michelle L Robbin, Miguel A Vazquez, Harold I Feldman
BACKGROUND: Half of surgically created arteriovenous fistulas (AVFs) require additional intervention to effectively support hemodialysis. Postoperative care and complications may affect clinical maturation. STUDY DESIGN: Hemodialysis Fistula Maturation (HFM) Study, a 7-center prospective cohort study. SETTING & PARTICIPANTS: 491 patients with single-stage AVFs who had neither thrombosis nor AVF intervention before a 6-week postoperative ultrasonographic examination and who required maintenance hemodialysis...
February 2, 2018: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Jean-Damien Combes, Isabelle Heard, Isabelle Poizot-Martin, Ana Canestri, Annie Lion, Lionel Piroth, Jean-Michel Didelot, Tristan Ferry, Olivier Patey, Lucie Marchand, Jean-Francois Flejou, Gary M Clifford, Isabelle Etienney
Background: We assessed prevalence and risk factors for anal HPV in HIV-positive MSM, who are at high-risk of HPV-related anal cancer. Methods: APACHES is a multicentric prospective study of anal HPV infection and lesions in HIV-positive MSM aged ≥35. At baseline, participants underwent anal swabs for HPV and cytology, plus high resolution anoscopy. High-risk (HR) HPV was tested by Cobas®4800, with genotyping of HR-HPV positives by PapilloCheck®. Results: Among 490 participants, prevalence of HPV16 and HR-HPV was 29% and 70%, respectively, and did not differ significantly by age, sexual behaviour, or markers of HIV or immune deficiency...
January 31, 2018: Journal of Infectious Diseases
Christopher King, Miguel A Lanaspa, Thomas Jensen, Dean R Tolan, L Gabriela Sánchez-Lozada, Richard J Johnson
Hyperuricemia is common in subjects with obesity, metabolic syndrome, and type 2 diabetes. For many years, hyperuricemia was attributed to the effects of insulin resistance to reduce urinary excretion of uric acid, and it was believed that uric acid may not have any causal role in the metabolic syndrome. However, in recent years, hyperuricemia has been found to independently predict the development of diabetes. Experimental studies have also shown that hyperuricemia may mediate insulin resistance, fatty liver, and dyslipidemia in both fructose-dependent and fructose-independent models of metabolic syndrome...
2018: Contributions to Nephrology
Jan C Frijters, Kimberley C Tsujimoto, Richard Boada, Stephanie Gottwald, Dina Hill, Lisa A Jacobson, Maureen W Lovett, E Mark Mahone, Erik G Willcutt, Maryanne Wolf, Joan Bosson-Heenan, Jeffrey R Gruen
The present study investigated the relation among reading skills and attributions, naming speed, and phonological awareness across a wide range of reading skill. Participants were 1,105 school-age children and youths from two understudied populations: African Americans and Hispanic Americans. Individual assessments of children ranging in age from 8 to 15 years were conducted for reading outcomes, cognitive and linguistic predictors of reading, and attributions for success and failure in reading situations. Quantile regressions were formulated to estimate these relations across the full skill span of each outcome...
January 2018: Reading Research Quarterly
Emily J Meyer, Gary Wittert
In men, obesity and metabolic complications are associated with lower serum testosterone (T) and dihydrotestosterone (DHT) and an increased risk of, and mortality from, multiple chronic diseases in addition to cardiovascular disease (CVD). The causal interrelationships between these factors remain a matter of debate. In men with untreated congenital and lifelong forms of hypogonadotropic hypogonadism, there appears to be no increased risk. Men with Klinefelter's syndrome have an increased risk of various types of cancers, as well as CVD, which persist despite T therapy...
January 30, 2018: Asian Journal of Andrology
Pierpaolo Di Nicolò
Renal involvement in some forms of acute or chronic diseases, such as heart failure or sepsis, presents with a complex pathophysiological basis that is not always clearly distinguishable. In these clinical settings, kidney failure is traditionally and almost exclusively attributed to renal hypoperfusion and it is commonly accepted that causal elements are pre-renal, such as a reduction in the ejection fraction or absolute or relative hypovolemia acting directly on oxygen transport mechanisms and renal autoregulation systems, causing a reduction of glomerular filtration rate...
January 31, 2018: Heart Failure Reviews
Somayeh Raiesdana
Existence of allocentric and egocentric systems for human navigation, mediating spatial and response learning respectively, has been discussed so far. It is controversial whether navigational strategies and their underlying learning systems and, accordingly, the activation of their associate brain areas are independent/parallel or whether they functionally/causally interact in a competitive or in a cooperative manner to solve navigational tasks. Insights of neural networks involved in reward-based navigation attributed to individual involvement or interactions of learning systems were searched...
2018: Journal of Integrative Neuroscience
Courtney A Polenick, Laura M Struble, Barbara Stanislawski, Molly Turnwald, Brianna Broderick, Laura N Gitlin, Helen C Kales
OBJECTIVES: Behavioral and psychological symptoms of dementia (BPSD) are common, often challenging to manage, and may erode caregivers' well-being. Few studies have explored caregivers' perspectives of what causes these behaviors, but such attributions may be important-particularly if they negatively impact the care dyad. This study examined causal attributions about BPSD among individuals caring for a family member with dementia. DESIGN: In-depth qualitative data were obtained from family caregivers of older adults with dementia...
December 13, 2017: American Journal of Geriatric Psychiatry
E Brenaut, S Bastuji-Garin
Epidemiology, which was initially confined to the distribution of diseases in populations (descriptive epidemiology) and the factors responsible for such distribution (analytical epidemiology), also involves the evaluation of diagnostic and therapeutic strategies, as well as prognostic factors. Epidemiology provides elements that form the basis for medical and public health decisions. Information is collected from systematic records, which include large databases, or through specific surveys. Descriptive studies utilise mortality rates, as well as incidence and prevalence figures...
January 19, 2018: Annales de Dermatologie et de Vénéréologie
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