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https://www.readbyqxmd.com/read/29908508/increment-of-ambient-exposure-to-fine-particles-and-the-reduced-human-fertility-rate-in-china-2000-2010
#1
Tao Xue, Tong Zhu
Epidemiological and toxicological studies suggest that exposure to ambient fine particles (PM2.5 ) can reduce human reproductive capacity. We previously reported, based on spatial epidemiology, that higher levels of PM2.5 exposure were associated with a lower fertility rate (FR) in China. However, that study was limited by a lack of temporal variation. Using first-difference regression, we linked temporal changes in FR and PM2.5 with adjustment for ecological covariates across 2806 counties in China during 2000-2010...
June 13, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29908445/technological-characteristics-of-pre-and-post-rigor-deboned-beef-mixtures-from-holstein-steers-and-quality-attributes-of-cooked-beef-sausage
#2
Anuraj T Sukumaran, Alexander J Holtcamp, Yan L Campbell, Derris Burnett, Mark W Schilling, Thu T N Dinh
The objective of this study was to determine the effects of deboning time (pre- and post-rigor), processing steps (grinding - GB; salting - SB; batter formulation - BB), and storage time on the quality of raw beef mixtures and vacuum-packaged cooked sausage, produced using a commercial formulation with 0.25% phosphate. The pH was greater in pre-rigor GB and SB than in post-rigor GB and SB (P < .001). However, deboning time had no effect on metmyoglobin reducing activity, cooking loss, and color of raw beef mixtures...
June 7, 2018: Meat Science
https://www.readbyqxmd.com/read/29908440/organometallic-compounds-in-the-discovery-of-new-agents-against-kinetoplastid-caused-diseases
#3
REVIEW
Mauro Ravera, Elsa Moreno-Viguri, Rocio Paucar, Silvia Pérez-Silanes, Elisabetta Gabano
The development of safe and affordable antiparasitic agents effective against neglected tropical diseases is a big challenge of the drug discovery. The drugs currently employed have limitations such as poor efficacy, drug resistance or side effects. Thus, the search for new promising drugs is more and more crucial. Metal complexes and, in particular, organometallic compounds may expand the list of the drug candidates due to the peculiar attributes that the presence of the metal core add to the organic fragment (e...
June 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29908434/characterizing-within-subject-variability-in-quantified-measures-of-balance-control-a-cohort-study
#4
Lise C Worthen-Chaudhari, Scott M Monfort, Courtney Bland, Xueliang Pan, Ajit M W Chaudhari
BACKGROUND: To longitudinally assess individuals using quantified measures, we must characterize within-subject variability (WSV) of the measures. RESEARCH QUESTION: What is the natural within-subject variability (WSV) that can be expected in postural control over 3+ days? METHODS: Thirteen individuals without orthopedic or neurologic impairment (mean(SD) = 55 (9) years; 76 (18) kg; 11 females/2 males) were recruited from a community workplace and consented to participate...
June 2, 2018: Gait & Posture
https://www.readbyqxmd.com/read/29908430/comparative-metagenomics-reveals-different-hydrocarbon-degradative-abilities-from-enriched-oil-drilling-waste
#5
Amanda P Napp, José Evandro S Pereira, Jorge S Oliveira, Rita C B Silva-Portela, Lucymara F Agnez-Lima, Maria C R Peralba, Fátima M Bento, Luciane M P Passaglia, Claudia E Thompson, Marilene H Vainstein
The oil drilling process generates large volumes of waste with inadequate treatments. Here, oil drilling waste (ODW) microbial communities demonstrate different hydrocarbon degradative abilities when exposed to distinct nutrient enrichments as revealed by comparative metagenomics. The ODW was enriched in Luria Broth (LBE) and Potato Dextrose (PDE) media to examine the structure and functional variations of microbial consortia. Two metagenomes were sequenced on Ion Torrent platform and analyzed using MG-RAST...
June 11, 2018: Chemosphere
https://www.readbyqxmd.com/read/29908358/from-lexical-regularities-to-axiomatic-patterns-for-the-quality-assurance-of-biomedical-terminologies-and-ontologies
#6
Philip van Damme, Manuel Quesada-Martínez, Ronald Cornet, Jesualdo Tomás Fernández-Breis
Ontologies and terminologies have been identified as key resources for the achievement of semantic interoperability in biomedical domains. The development of ontologies is performed as a joint work by domain experts and knowledge engineers. The maintenance and auditing of these resources is also the responsibility of such experts, and this is usually a time-consuming, mostly manual task. Manual auditing is impractical and ineffective for most biomedical ontologies, especially for larger ones. An example is SNOMED CT, a key resource in many countries for codifying medical information...
June 13, 2018: Journal of Biomedical Informatics
https://www.readbyqxmd.com/read/29908251/management-and-outcomes-of-staphylococcus-aureus-bacteraemia-at-a-south-african-referral-hospital-a-prospective-observational-study
#7
Nicola Steinhaus, Mohammed Al-Talib, Prudence Ive, Tom Boyles, Colleen Bamford, Mary-Ann Davies, Marc Mendelson, Sean Wasserman
OBJECTIVES: Limited evidence exists on the management and outcomes of Staphylococcus aureus bacteraemia (SAB) in resource-limited settings. The aim of this study was to describe a cohort of South African patients with SAB, and explore the factors associated with complicated infection and death. METHOD: A prospective observational study of patients over the age of 13 years admitted to a South African referral hospital with SAB. RESULTS: One hundred SAB infection episodes occurring in 98 patients were included...
June 13, 2018: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29908227/hypogastric-preservation-using-retrograde-endovascular-bypass
#8
Mathew Wooster, Paul Armstrong, Martin Back
OBJECTIVE: Maintenance of pelvic circulation has been connected to reduced risks of ischemic colitis, buttock claudication, erectile dysfunction, and spinal cord ischemia during the treatment of extensive aorto-iliac aneurysmal disease. We evaluate the mid to late follow up of a cohort of patients treated using one preservation technique, the endovascular external (EIA) to internal (IIA) iliac artery bypass. METHODS: All patients undergoing elective retrograde EIA-IIA endovascular bypass at a single institution were retrospectively reviewed over a ten-year period from 2006-2016...
June 13, 2018: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/29908200/differential-effects-of-withdrawal-from-intermittent-and-continuous-nicotine-exposure-on-reward-deficit-and-somatic-aspects-of-nicotine-withdrawal-and-expression-of-%C3%AE-4%C3%AE-2-nachrs-in-wistar-male-rats
#9
Svetlana Semenova, Xinchun Jin, Tristan D McClure-Begley, Matthew Philip Tadman, Michael J Marks, Athina Markou
BACKGROUND: Chronic nicotine exposure produces neuroadaptations in brain reward systems and α4β2 nicotinic acetylcholine receptors (nAChRs) in the corticolimbic brain areas. We previously demonstrated opposite effects of nicotine exposure delivered by self-administration or pumps on brain reward thresholds that can be attributed to the different temporal pattern and contingency of nicotine exposure. We investigated the effects of these two factors on reward thresholds and somatic signs during nicotine withdrawal, and on nAChRs binding in corticolimbic brain areas...
June 13, 2018: Pharmacology, Biochemistry, and Behavior
https://www.readbyqxmd.com/read/29908140/cryptosporidium-genotyping-in-europe-the-current-status-and-processes-for-a-harmonised-multi-locus-genotyping-scheme
#10
Rachel M Chalmers, Gregorio Pérez-Cordón, Simone M Cacció, Christian Klotz, Lucy J Robertson
Due to the occurrence of genetic recombination, a reliable and discriminatory method to genotype Cryptosporidium isolates at the intra-species level requires the analysis of multiple loci, but a standardised scheme is not currently available. A workshop was held at the Robert Koch Institute, Berlin in 2016 that gathered 23 scientists with appropriate expertise (in either Cryptosporidium genotyping and/or surveillance, epidemiology or outbreaks) to discuss the processes for the development of a robust, standardised, multi-locus genotyping (MLG) scheme and propose an approach...
June 13, 2018: Experimental Parasitology
https://www.readbyqxmd.com/read/29908082/the-role-of-sigma-1-receptor-in-sex-specific-heat-shock-response-in-an-experimental-rat-model-of-renal-ischemia-reperfusion-injury
#11
Adam Hosszu, Zsuzsanna Antal, Apor Veres-Szekely, Lilla Lenart, Dora Bianka Balogh, Edgar Szkibinszkij, Lilla Illesy, Judit Hodrea, Nora F Banki, Laszlo Wagner, Adam Vannay, Attila J Szabo, Andrea Fekete
We previously showed that female rats are more protected against renal ischemia/reperfusion (I/R) injury than males, which is partly attributed to their more pronounced heat shock response. We recently described that Sigma-1 receptor (S1R) activation improves postischemic survival and renal function. 17β-estradiol activates S1R, thus here we investigated the role of sex-specific S1R activation and heat shock response in severe renal I/R injury. Proximal tubular cells were treated with 17β-estradiol, which caused direct S1R activation and subsequent induction of heat shock response...
June 16, 2018: Transplant International: Official Journal of the European Society for Organ Transplantation
https://www.readbyqxmd.com/read/29908002/shielding-a-high-sensitivity-digital-detector-from-electromagnetic-interference
#12
David E Hintenlang, Xia Jiang, Kevin J Little
PURPOSE: To document a study in shielding a high-sensitivity digital mammography system detector from AC magnetic fields of magnitudes great enough to induce imaging artifacts. METHODS/MATERIALS: Preliminary evaluation of AC magnetic fields at a site designated for a digital breast tomosynthesis (DBT) system raised concerns that the magnetic component of electromagnetic interference (EMI) may be great enough to induce imaging artifacts. Subsequent measurements using digital detector arrays from two separate manufacturers verified this concern, and AC magnetic fields were mapped, spatially and temporally, throughout the area of concern...
June 15, 2018: Journal of Applied Clinical Medical Physics
https://www.readbyqxmd.com/read/29907986/redox-triggered-folding-of-self-assembled-coordination-polymers-incorporating-viologen-units
#13
Wathiq Sattar Abdul-Hassan, Denis Roux, Christophe Bucher, Saioa Cobo, Florian Molton, Eric Saint-Aman, Guy Royal
We report the study of stimuli-responsive Zn(II) and Fe(II) coordination polymers (MC34+ or MC24+ with M = Fe2+ or Zn2+). These soluble metallopolymers were formed spontaneously by reaction of an organic ligand (C34+ or C24+) with one molar equivalent of metal ions. The C34+ and C24+ ligands incorporate two chelating terpyridine groups bridged by a redox responsive hinge featuring two viologen units (viologen = N,N'-dialkyl-4,4'-bipyridinium) linked either through propyl (C34+) or ethyl (C24+) chains. The viologen units in the polymer chains were reduced (1e per viologen group) either by bulk electrolysis or by visible-light irradiation carried out in the presence of a photosensitizer...
June 15, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29907971/loss-of-specificity-variants-of-wzxc-suggest-that-substrate-recognition-is-coupled-with-transporter-opening-in-mop-family-flippases
#14
Lok To Sham, Sanduo Zheng, Anastasiya A Yakhnina, Andrew C Kruse, Thomas G Bernhardt
Bacteria produce a variety of surface-exposed polysaccharides important for cell integrity, biofilm formation, and evasion of the host immune response. Synthesis of these polymers often involves the assembly of monomer oligosaccharide units on the lipid carrier undecaprenyl-phosphate at the inner face of the cytoplasmic membrane. For many polymers, including cell wall peptidoglycan, the lipid-linked precursors must be transported across the membrane by flippases to facilitate polymerization at the membrane surface...
June 15, 2018: Molecular Microbiology
https://www.readbyqxmd.com/read/29907863/attenuation-of-retinal-vascular-development-in-neonatal-mice-subjected-to-hypoxic-ischemic-encephalopathy
#15
Ismail S Zaitoun, Ulas Cikla, Dila Zafer, Eshwar Udho, Reem Almomani, Andrew Suscha, Pelin Cengiz, Christine M Sorenson, Nader Sheibani
A significant proportion of children that survive hypoxic-ischemic encephalopathy (HIE) develop visual impairment. These visual deficits are generally attributed to injuries that occur in the primary visual cortex and other visual processing systems. Recent studies suggested that neuronal damage might also occur in the retina. An important structure affecting the viability of retinal neurons is the vasculature. However, the effects of HIE on the retinal neurovasculature have not been systemically evaluated...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907789/place-cell-like-activity-in-the-primary-sensorimotor-and-premotor-cortex-during-monkey-whole-body-navigation
#16
A Yin, P H Tseng, S Rajangam, M A Lebedev, M A L Nicolelis
Primary motor (M1), primary somatosensory (S1) and dorsal premotor (PMd) cortical areas of rhesus monkeys previously have been associated only with sensorimotor control of limb movements. Here we show that a significant number of neurons in these areas also represent body position and orientation in space. Two rhesus monkeys (K and M) used a wheelchair controlled by a brain-machine interface (BMI) to navigate in a room. During this whole-body navigation, the discharge rates of M1, S1, and PMd neurons correlated with the two-dimensional (2D) room position and the direction of the wheelchair and the monkey head...
June 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29907593/the-role-of-pyruvate-dehydrogenase-kinase-4-pdk4-in-bladder-cancer-and-chemoresistance
#17
Benjamin L Woolbright, Dharamainder Choudhary, Andrew Mikhalyuk, Cassandra Trammel, Sambantham Shanmugam, Erika Abbott, Carol C Pilbeam, John A Taylor
Advanced bladder cancer (BCa) remains a major source of mortality, with poor treatment options. Cisplatin based chemotherapy is the standard treatment, however many patients are or become resistant. One potential cause of chemoresistance is the Warburg Effect, a metabolic switch to aerobic glycolysis that occurs in many cancers. Upregulation of the pyruvate dehydrogenase kinase family (PDK1-4) is associated with aerobic glycolysis and chemoresistance through inhibition of the pyruvate dehydrogenase complex (PDH)...
June 15, 2018: Molecular Cancer Therapeutics
https://www.readbyqxmd.com/read/29907537/first-report-on-giardia-duodenalis-assemblage-f-in-slovakian-children-living-in-poor-environmental-conditions
#18
Jana Pipiková, Ingrid Papajová, Viktória Majláthová, Jindřich Šoltys, Júlia Bystrianska, Ingrid Schusterová, Veronika Vargová
BACKGROUND: Giardiasis is one of the most common gastrointestinal infections of humans and animals attributable to complex of eight morphologically identical genetic assemblages, further divided into sub-assemblages. Disease is common for a wide range of hosts and genetic characterization is needed for better understanding of multifaceted epidemiology for this protozoan parasite. The aim of this study was to identify genetic heterogeneity in assemblages and sub-assemblages of Giardiaduodenalis circulating among the children population living in deprived socioeconomic conditions...
June 2, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29907429/comprehensive-approach-to-reestablishing-form-and-function-after-radical-parotidectomy
#19
Peter J Ciolek, Brandon L Prendes, Michael A Fritz
INTRODUCTION: The reconstructive goals following radical parotidectomy include restoration of symmetry, reanimation of the face, and reestablishment of oral competence. We present our experience utilizing the anterolateral thigh (ALT) free flap, orthodromic temporalis tendon transfer (OTTT), and facial nerve cable grafting to reestablish form and function. MATERIAL AND METHODS: From 2010 to 2016, 17 patients underwent radical parotidectomy followed by immediate reconstruction...
June 7, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29907232/intramuscular-e-selectin-adeno-associated-virus-gene-therapy-promotes-wound-healing-in-an-ischemic-mouse-model
#20
Punam P Parikh, Roberta M Lassance-Soares, Hongwei Shao, Manuela M Regueiro, Yan Li, Zhao-Jun Liu, Omaida C Velazquez
BACKGROUND: Poor wound healing in critical limb ischemia (CLI) is attributed to impaired neovascularization and reperfusion. Optimizing the ischemic wound with adhesion molecules that enhance stem cell homing may revolutionize treatment. The purpose of this study is to test the efficacy of adhesion molecule E-selectin on wound healing in an ischemic mouse wound. METHODS: Adult FVB/NJ mice underwent unilateral femoral artery and vein ligation to induce CLI. A 4-mm punch biopsy wound was created on the anterior thigh to simulate ischemic wounds...
August 2018: Journal of Surgical Research
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