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JOURNAL ARTICLE
M A Baxter, M Denholm, S J Kingdon, S Kathirgamakarthigeyan, S Parikh, R Shakir, R Johnson, H Martin, M Walton, W Yao, A Swan, C Samuelson, X Ren, A Cooper, H-L Gray, S Clifton, J Ball, G Gullick, M Anderson, L Dodd, H Hayhurst, M Salama, R Shotton, F Britton, T Christodoulou, A Abdul-Hamid, A Eichholz, R M Evans, P Wallroth, F Gibson, K Poole, M Rowe, J Harris
BACKGROUND: The incidence of cancer diagnosed during pregnancy is increasing. Data relating to investigation and management, as well as maternal and foetal outcomes is lacking in a United Kingdom (UK) population. METHODS: In this retrospective study we report data from 119 patients diagnosed with cancer during pregnancy from 14 cancer centres in the UK across a five-year period (2016-2020). RESULTS: Median age at diagnosis was 33 years, with breast, skin and haematological the most common primary sites...
February 21, 2024: British Journal of Cancer
#22
JOURNAL ARTICLE
Véronique Le Guern, Mathias Rossignol, Jacques Lepercq
Maternal deaths from indirect obstetric causes result from a pre-existing condition or a condition that occurred during pregnancy without obstetric causes but was aggravated by the physiological effects of pregnancy. Twenty-nine deaths with an indirect cause related to a pre-existing condition, excluding circulatory diseases or infections, were analysed by the expert committee. Pre-pregnancy pathology was documented in 16 women (epilepsy, n=7; amyloid angiopathy, n=1; Dandy Walker syndrome, n=1; autoimmune diseases, n=3; diffuse infiltrative pneumonitis, n=1; thrombotic thrombocytopenic purpura, n=1; ovarian cancer in fragile X, n=1; major sickle cell disease, n=1)...
February 17, 2024: Gynecologie, Obstetrique, Fertilite & Senologie
#23
JOURNAL ARTICLE
Florentia Vlachou, Despoina Iakovou, Jahnavi Daru, Rehan Khan, Litha Pepas, Siobhan Quenby, Stamatina Iliodromiti
BACKGROUND: Evidence suggests common pathways between pregnancy losses and subsequent long-term maternal morbidity, rendering pregnancy complications an early chronic disease marker. There is a plethora of studies exploring associations between miscarriage and stillbirth with long-term adverse maternal health; however, these data are inconclusive. METHODS AND FINDINGS: We systematically searched MEDLINE, EMBASE, AMED, BNI, CINAHL, and the Cochrane Library with relevant keywords and MeSH terms from inception to June 2023 (no language restrictions)...
February 2024: PLoS Medicine
#24
JOURNAL ARTICLE
Jaitri Joshi, Yue Xiong, Molly Kuhn, Abigail B Radcliff, Tracy L Baker, Jyoti J Watters, Lisa M Arendt
An adverse perinatal environment can increase long-term cancer risk, although the precise nature of associated perinatal triggers remain unknown. Sleep apnea is a common condition during pregnancy, characterized by recurrent cessations in breathing during sleep, and the potential consequences of sleep apnea during pregnancy as it relates to breast cancer risk in offspring have not been explored. To model sleep apnea, Sprague-Dawley dams were exposed during gestation to nightly intermittent hypoxia (GIH) or normoxia (GNx), and the mammary glands of female offspring were examined...
January 29, 2024: Cells
#25
REVIEW
Kjetil Retterstøl, Fredrik Rosqvist
Two de novo NNR2022 systematic reviews (SRs) as well as 21 qualified SRs (qSRs) were available. A literature search yielded an additional ~70 SRs, meta-analyses and biomarker papers. Diets lower in total fat are associated with reductions in body weight and blood pressure compared with diets higher in total fat in adults. Partial replacement of saturated fatty acid (SFA) with n-6 polyunsaturated fatty acid (PUFA) improves blood lipid profile, decreases the risk of cardiovascular disease (CVD), improves glucose-insulin homeostasis and may decrease the risk of total mortality...
2024: Food & Nutrition Research
#26
JOURNAL ARTICLE
Kali Xu, Maggie Chung, Jessica H Hayward, Tatiana Kelil, Amie Y Lee, Kimberly M Ray
The breasts undergo marked physiologic changes during lactation that can make conventional imaging evaluation with mammography and US challenging. MRI can be a valuable diagnostic aid to differentiate physiologic and benign processes from malignancy in patients who are lactating. In addition, MRI may allow more accurate delineation of disease involvement than does conventional imaging and assists in locoregional staging, screening of the contralateral breast, assessment of response to neoadjuvant chemotherapy, and surgical planning...
February 2024: Radiographics: a Review Publication of the Radiological Society of North America, Inc
#27
JOURNAL ARTICLE
R De Santis, G Cagnoli, B Rinaldi, D Consonni, Beatrice Conti, M Eoli, A Liguori, M Cosentino, G Carrafiello, O Garrone, M Giroda, C Cesaretti, M S Sfondrini, D Gambini, F Natacci
Neurofibromatosis type 1 (NF1) is an autosomal dominant condition caused by neurofibromin haploinsufficiency due to pathogenic variants in the NF1 gene. Tumor predisposition has long been associated with NF1, and an increased breast cancer (BC) incidence and reduced survival have been reported in recent years for women with NF1. As breast density is another known independent risk factor for BC, this study aims to evaluate the variability of breast density in patients with NF1 compared to the general population...
January 25, 2024: Familial Cancer
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JOURNAL ARTICLE
Vera Loizzi, Michele Mongelli, Francesca Arezzo, Isabella Romagno, Gerardo Cazzato, Ondina Popescu, Francesco Legge, Paolo Trerotoli, Erica Silvestris, Anila Kardhashi, Gennaro Cormio
OBJECTIVES: The objective of this multicenter retrospective study aimed to evaluate the association of clinical variables and the incidence of ovarian cancer in patients with BRCA 1-2 mutation carriers who underwent risk-reducing salpingo-oophorectomy. DESIGN: Patients with a pathogenic mutation of BRCA 1-2 genes and with no evidence of disease are considered eligible. The exclusion criterion was the refusal to undergo the surgery. The retrospective study included all risk-reducing salpingo-oophorectomy (RRSO) performed from May 2015 to April 2022 in the three gynecological Institutions of Southern Italy for were included in this retrospective study...
January 19, 2024: Gynecologic and Obstetric Investigation
#29
REVIEW
Petra Dahms, Traci R Lyons
Lymphatic vasculature has been shown to promote metastatic spread of breast cancer. Lymphatic vasculature, which is made up of larger collecting vessels and smaller capillaries, has specialized cell junctions that facilitate cell intravasation. Normally, these junctions are designed to collect immune cells and other cellular components for immune surveillance by lymph nodes, but they are also utilized by cancer cells to facilitate metastasis. Although lymphatic development overall in the body has been well-characterized, there has been little focus on how the lymphatic network changes in the mammary gland during stages of remodeling such as pregnancy, lactation, and postpartum involution...
January 13, 2024: Journal of Mammary Gland Biology and Neoplasia
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JOURNAL ARTICLE
Serena Girardelli, Barbara Bonomo, Margherita Papale, Eugenia di Loreto, Elena Grossi, Giovanna Scarfone, Emanuela Rabaiotti, Luca Valsecchi, Giorgia Mangili, Massimo Candiani, Fedro Peccatori
BACKGROUND: Pregnancy associated breast cancer is the most common cancer diagnosed during pregnancy. When chemotherapy is indicated, although it is more common to use anthracycline-based chemotherapy as a first treatment, we suggest weekly paclitaxel as a valid alternative both in the adjuvant and neoadjuvant setting, as this allows for weekly assessment of maternal-fetal well-being and a quicker maternal and fetal bone marrow recovery in cases of unexpected preterm delivery. PATIENTS AND METHODS: We present a case series of pregnant breast cancer patients treated with weekly paclitaxel between 2016 and 2022...
December 13, 2023: Clinical Breast Cancer
#31
Priyanshu Nain, Lakshya Seth, Ashley Shawn Bell, Priyanka Raval, Gyanendra Sharma, Monique Bethel, Garima Sharma, Avirup Guha
Pregnancy-associated breast cancer is challenging to treat. Treatment with chemotherapeutic agents such as anthracyclines poses a risk of cardiotoxicity, despite being considered safe after the second trimester of pregnancy. Management requires multidisciplinary comanagement with cardio-obstetrics, cardiology-oncology, maternal-fetal medicine, and oncology.
December 20, 2023: JACC. Case reports
#32
JOURNAL ARTICLE
Jamar Hawkins, Eva P Browne, Kathleen F Arcaro, Yubing Sun
Breastmilk is a reliable source of biomarker-containing, sloughed breast cells that have the potential to give valuable health insights to new mothers. Furthermore, known DNA-based markers for pregnancy-associated breast cancer are chemically stable and can be safely stored on a commercially available FTA® Elute Micro (EM) card, which can subsequently be mailed to a testing facility for the cost of a stamp. In theory, this archiving process can be performed by nonprofessionals in very low-resource settings as it simply requires placing a drop of breastmilk on an EM card...
January 8, 2024: Lab on a Chip
#33
JOURNAL ARTICLE
Billy Ho Hung Cheung, Vivian Chi Mei Man, Goby Tze Wa Sham, Lorraine Chow, Michael Co, Ava Kwong
BACKGROUND: The incidence of pregnancy-associated breast cancer (PABC) is increasing. Its tumor characteristics and overall survival compared with those in nonpregnant patients remain controversial. While there have been suggestions that PABC patients have a 40 % increase in the risk of death compared to non-pregnant patients, other studies suggested similar disease outcomes. This study aims to review our local experience with PABC. METHODS: Twenty-eight patients diagnosed with PABC and twenty-eight patients diagnosed at premenopausal age randomly selected by a computer-generated system during the same period were recruited...
December 20, 2023: Cancer Treatment and Research Communications
#34
JOURNAL ARTICLE
Gurjot Gill, Vasily Giannakeas, Stephanie Read, Iliana C Lega, Baiju R Shah, Lorraine L Lipscombe
AIM: Diabetes is associated with an increased risk of several cancers, including postmenopausal breast cancer. The evidence for higher breast cancer risk after diabetes in pregnancy is conflicting. We compared the incidence of breast and other cancers between pregnant women with and without diabetes. METHODS: Propensity-matched retrospective cohort study using population-based healthcare databases from Ontario, Canada. Those deliveries with gestational diabetes mellitus (GDM) and pre-gestational diabetes mellitus (pre-gestational DM) were identified, and matched to deliveries without diabetes mellitus (non-DM)...
December 29, 2023: Canadian Journal of Diabetes
#35
JOURNAL ARTICLE
Chelsea Pyle, Molly Hill, Shahrzad Sharafi, Camelia Forton, Roya Sohaey
Pregnancy-associated breast cancer is characterized as breast cancer diagnosed during pregnancy, within the first postpartum year, or during lactation. It usually presents as a palpable mass, although the large majority of palpable masses during pregnancy are benign. Breast cancer is the most common invasive malignancy diagnosed during pregnancy and lactation, and its incidence is increasing as more women delay childbearing. Understanding the appropriate methods for screening and diagnostic workup of breast findings in this population is imperative for radiologists to promptly diagnose pregnancy-associated breast cancer...
November 30, 2023: Journal of breast imaging
#36
JOURNAL ARTICLE
Nathalie Auger, Amanda Maniraho, Aimina Ayoub, Laura Arbour
BACKGROUND: Congenital anomalies are common, but the possibility that maternal cancer increases the chance of having a child with a birth defect is not fully understood. OBJECTIVES: To examine the association between maternal cancer before or during pregnancy and the risk of birth defects in offspring. METHODS: We conducted a retrospective cohort study of live births in Quebec, Canada, between 1989 and 2022 using hospital data. The main exposure measure was maternal cancer before or during pregnancy...
December 19, 2023: Paediatric and Perinatal Epidemiology
#37
JOURNAL ARTICLE
Matteo Lambertini, Eva Blondeaux, Elisa Agostinetto, Anne-Sophie Hamy, Hee Jeong Kim, Antonio Di Meglio, Rinat Bernstein Molho, Florentine Hilbers, Katarzyna Pogoda, Estela Carrasco, Kevin Punie, Jyoti Bajpai, Michail Ignatiadis, Halle C F Moore, Kelly-Anne Phillips, Angela Toss, Christine Rousset-Jablonski, Fedro A Peccatori, Tiphaine Renaud, Alberta Ferrari, Shani Paluch-Shimon, Robert Fruscio, Wanda Cui, Stephanie M Wong, Claudio Vernieri, Kathryn J Ruddy, Maria Vittoria Dieci, Alexios Matikas, Mariya Rozenblit, Cynthia Villarreal-Garza, Laura De Marchis, Lucia Del Mastro, Fabio Puglisi, Maria Del Pilar Estevez-Diz, Kenny A Rodriguez-Wallberg, Bela Mrinakova, Sarah Meister, Luca Livraghi, Florian Clatot, Rinat Yerushalmi, Carmine De Angelis, Rodrigo Sánchez-Bayona, Icro Meattini, Natalia Cichowska-Cwalinska, Martine Berlière, Mahmoud Salama, Ugo De Giorgi, Amir Sonnenblick, Camila Chiodi, Young-Jin Lee, Camille Maria, Hatem A Azim, Luca Boni, Ann H Partridge
IMPORTANCE: Young women with breast cancer who have germline pathogenic variants in BRCA1 or BRCA2 face unique challenges regarding fertility. Previous studies demonstrating the feasibility and safety of pregnancy in breast cancer survivors included limited data regarding BRCA carriers. OBJECTIVE: To investigate cumulative incidence of pregnancy and disease-free survival in young women who are BRCA carriers. DESIGN, SETTING, AND PARTICIPANTS: International, multicenter, hospital-based, retrospective cohort study conducted at 78 participating centers worldwide...
December 7, 2023: JAMA
#38
JOURNAL ARTICLE
Ana S Ferrigno Guajardo, Bryan F Vaca-Cartagena, Erica L Mayer, Chayma Bousrih, Oke Oluchi, Cristina Saura, Fedro Peccatori, Wendy Muñoz-Montaño, Alvaro Cabrera-Garcia, Matteo Lambertini, Luis Corrales, Andrea Becerril-Gaitan, Tal Sella, Alexandra Bili Newman, Barbara Pistilli, Ashley Martinez, Carolina Ortiz, Laia Joval-Ramentol, Giovanna Scarfone, Barbara Buonomo, Fernando Lara-Medina, Jacqueline Sanchez, Luca Arecco, Allan Ramos-Esquivel, Snezana Susnjar, Gilberto Morgan, Cynthia Villarreal-Garza, Hatem A Azim
INTRODUCTION: The addition of taxanes to anthracycline-based chemotherapy is considered standard of care in the treatment of breast cancer. However, there are insufficient data regarding the safety of taxanes during pregnancy. The aim of this study was to describe the incidence of obstetric and neonatal adverse events associated with the use of taxane-containing chemotherapy regimens for the treatment of breast cancer during pregnancy. METHODS: This is a multicenter, international cohort study of breast cancer patients treated with taxanes during pregnancy...
February 8, 2024: Journal of the National Cancer Institute
#39
JOURNAL ARTICLE
Nicolas Ramírez-Torres, Rodolfo Rivas-Ruiz, Alfonso Reyes-López
Background Breast cancer is one of the most common cancer types diagnosed during pregnancy; the presence of any neoplasm in pregnant women faces clinical dilemmas and challenges in cancer and pregnancy management. Pregnancy-associated breast cancer (PABC) is defined as breast cancer diagnosed during pregnancy or within one year after delivery. The aim of this study was to describe tumor clinicopathological characteristics and pregnancy outcomes in PABC patients. Materials and methods This is a retrospective cohort assessing PABC patients...
October 2023: Curēus
#40
JOURNAL ARTICLE
Fang-Ping Chen, Mei-Hua Chien, Chun-Hui Lee
OBJECTIVE: The data on the association between phthalates and breast cancer risk remains inconsistent. This study aimed to explore the possible mechanism of low-dose exposures of phthalates, including Butyl benzyl phthalate (BBP), di(n-butyl) phthalate (DBP), and di(20ethylhexyl) phthalate (DEHP), on breast tumorigenesis. METHODS AND METHODS: MCF-10A normal breast cells were treated with phthalates (10 and 100 nM) and 17β-estradiol (E2 , 10 nM), which were co-cultured with fibroblasts from normal mammary tissue...
November 2023: Taiwanese Journal of Obstetrics & Gynecology
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