keyword
https://read.qxmd.com/read/38455863/management-of-a-pure-uterine-corpus-rhabdomyosarcoma-in-a-postmenopausal-patient-a-rare-case-report-and-review-of-the-literature
#1
John Lugata, Caleigh Smith, Onesmo Mrosso, Doris Rwenyagila, Baraka Shao, Alex Mremi
KEY CLINICAL MESSAGE: Rhabdomyosarcoma of the female genital tract often involves the vagina and cervix. It usually occurs in infants and children. Such tumors are uncommon in the uterus, especially in adults. Treatment options are based on studies of younger individuals. ABSTRACT: Rhabdomyosarcoma (RMS) is a malignant mesenchymal neoplasm with a tendency to differentiate into skeletal muscle cells. RMS is an aggressive tumor that tends to develop in children and younger patients...
March 2024: Clinical Case Reports
https://read.qxmd.com/read/38417940/spinal-intramedullary-uterine-carcinosarcoma-metastasis
#2
JOURNAL ARTICLE
Waldo Solis, Andrew M Youssef, Richard Shaw, Yingda Li
Intramedullary spinal cord metastases (ISCM) are a rare and challenging manifestation of metastatic cancer that have devastating impacts on the individual's neurological function, survival expectancy and overall quality of life. Given the rarity and poor prognosis, there is a lack of consensus in management. Uterine carcinosarcoma itself is a rare cancer, accounting for less than 3% of all uterine cancers. It carries a poor prognosis, with only one-third of patients surviving beyond 5 years. There are no previous reports of uterine carcinosarcoma metastases to the spinal cord...
February 27, 2024: BMJ Case Reports
https://read.qxmd.com/read/38392588/prognostic-value-of-lymph-node-ratio-in-patients-with-uterine-carcinosarcoma
#3
JOURNAL ARTICLE
Rasiah Bharathan, Stephan Polterauer, Martha C Lopez-Sanclemente, Hanna Trukhan, Andrei Pletnev, Angel G Heredia, Maria M Gil, Irina Bakinovskaya, Alena Dalamanava, Margarita Romeo, Dzmitry Rovski, Laura Baquedano, Luis Chiva, Richard Schwameis, Ignacio Zapardiel, On Behalf Of Sarcut Study Group
Uterine carcinosarcoma is a rare high-grade endometrial cancer. Controversy has surrounded a number of aspects in the diagnosis and management of this unique clinicopathological entity, including the efficacy of adjuvant therapy, which has been questioned. An unusual surgico-pathological parameter with prognostic significance in a number of tumour sites is the lymph node ratio (LNR). The availability of data in this respect has been scarce in the literature. The primary aim of this collaborative study was to evaluate the prognostic value of LNR in patients with uterine carcinosarcoma...
January 30, 2024: Journal of Personalized Medicine
https://read.qxmd.com/read/38390260/malignant-mixed-mullerian-tumors-a-seer-database-review-of-rurality-and-treatment-modalities-on-disease-outcome
#4
JOURNAL ARTICLE
Neusha Zadeh, Arjun Bhatt, Vaishnavi Sripiparu, Melisa Pasli, George Edwards, Michael C Larkins, M Sean Peach
INTRODUCTION: Malignant Mixed Mullerian Tumors (MMMT) are rare and poorly understood sarcomas with limited research on risk factors, pathogenesis, and optimal treatments. This study aimed to address this knowledge gap and explore the impact of community size, patient characteristics, disease characteristics, and treatment modalities on MMMT outcomes. METHODS: Using the Surveillance, Epidemiology, and End Results database (SEER), the largest SEER cohort to date of 3,352 MMMT patients was analyzed for demographic factors, treatment modalities, and histologic characteristics...
2024: Frontiers in Oncology
https://read.qxmd.com/read/38373912/clinical-and-multiparametric-mri-features-for-differentiating-uterine-carcinosarcoma-from-endometrioid-adenocarcinoma
#5
JOURNAL ARTICLE
Xiaodan Chen, Qingyong Guo, Xiaorong Chen, Wanjing Zheng, Yaqing Kang, Dairong Cao
INTRODUCTION: The purpose of our study was to differentiate uterine carcinosarcoma (UCS) from endometrioid adenocarcinoma (EAC) by the multiparametric magnetic resonance imaging (MRI) features. METHODS: We retrospectively evaluated clinical and MRI findings in 17 patients with UCS and 34 patients with EAC proven by histologically. The following clinical and pathological features were evaluated: post- or pre-menopausal, clinical presentation, invasion depth, FIGO stage, lymphaticmetastasis...
February 19, 2024: BMC Medical Imaging
https://read.qxmd.com/read/38370501/uterine-carcinosarcoma-with-heterologous-mesenchymal-element-a-case-report-of-a-rare-and-aggressive-tumor
#6
Shahd Asfer, Suhair Hmidan Samsam, Rama Zakkar, Habib Jarbouh
Uterine carcinosarcoma (UCS), also known as malignant mixed Müllerian tumor, is a rare malignancy, which consists of both carcinomatous and sarcomatous elements, with a clinical picture resembling endometrial carcinoma. We report a case of a 74-year-old woman is reported with UCS, diagnosed after a 7 months history of vaginal bleeding and abdominal pain. Previous transvaginal sonography showed nonspecific findings, but a repeated one revealed a central uterine mass. Dilatation and curettage and several biopsies were performed...
February 2024: Oxford Medical Case Reports
https://read.qxmd.com/read/38318319/the-role-of-taok3-in-cancer-progression-and-development-as-a-prognostic-marker-a-pan-cancer-analysis-study
#7
JOURNAL ARTICLE
Glowi Alasiri, Bahauddeen Alrfaei, Ali M Alaseem, Osama A AlKhamees, Jehad A Aldali, Ala M Aljehani, Abdulaziz Alfahed, Mohammad Azhar Aziz, Ghadir Almuhaini, Mana M Alshehri
The protein kinase TAOK3, belongs to the MAP kinase family, is one of three closely related members, namely TAOK1, TAOK2, and TAOK3. We performed a pan-cancer investigation of TAOK3 across different cancer types, including uterine carcinosarcoma, adenocarcinoma of the stomach and pancreas, and endometrial carcinoma of the uterus, to better understand TAOK3's role in cancer. In at least 16 types of cancer, our findings indicate that TAOK3 expression levels differ considerably between normal and tumor tissues...
March 2024: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://read.qxmd.com/read/38311895/ever-expanding-morphologic-patterns-of-mesonephric-like-adenocarcinomas-of-the-uterine-corpus-a-report-of-two-tumors-and-a-brief-review-of-the-literature
#8
JOURNAL ARTICLE
M Ruhul Quddus, Cara A Mathews, Kamaljeet Singh
Mesonephric-like adenocarcinoma (MLA) of the endometrium shows a variety of morphologic appearances, including small glands, tubules with eosinophilic materials in the lumen, prominent papillary patterns, spindled cells, solid formations, and corded and hyalinized patterns. Unique morphology, characteristic immunohistochemical staining patterns, molecular alterations, and awareness of the pathologists make it possible to identify this tumor accurately. This report of two additional morphologic patterns, intestinal goblet cells mimicking intestinal-type mucinous carcinoma and squamous differentiation with spindle and epithelioid cells mimicking carcinosarcoma of the endometrium will expand the literature on MLA...
February 4, 2024: International Journal of Surgical Pathology
https://read.qxmd.com/read/38309028/social-determinants-of-health-in-uterine-carcinosarcoma
#9
JOURNAL ARTICLE
Larissa L Aroche Gutierrez, Donald D McIntire, Jayanthi Lea, Salvatore LoCoco, David Scott Miller
OBJECTIVE: UCS survival outcome disparities by race have been reported. We aimed to investigate social determinants of health (SDOH) and their relation to survival outcomes in women at two affiliated high-volume institutions serving a racially and economically diverse population. METHODS: Women diagnosed with stage I-IV UCS treated at St. Paul University Hospital, University of Texas Southwestern (UTSW) Zale Lipshy Pavilion-William P. Clements Jr. University Hospital, and Parkland Memorial Hospital between 1992 and 2022 were eligible...
February 2, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38277919/racial-ethnic-and-country-of-origin-disparities-in-aggressive-endometrial-cancer-histologic-subtypes
#10
JOURNAL ARTICLE
Stuart S Winkler, Chunqiao Tian, Yovanni Casablanca, Nicholas W Bateman, Suzanne Jokajtys, Calen W Kucera, Christopher M Tarney, John K Chan, Michael T Richardson, Daniel S Kapp, Cheng-I Liao, Chad A Hamilton, Charles A Leath, Megan Reddy, Michele L Cote, Timothy D O'Connor, Nathaniel L Jones, Rodney P Rocconi, Matthew A Powell, John Farley, Craig D Shriver, Thomas P Conrads, Neil T Phippen, G Larry Maxwell, Kathleen M Darcy
OBJECTIVE: This study investigated the risk of an aggressive endometrial cancer (EC) diagnosis by race, ethnicity, and country of origin to further elucidate histologic disparities in non-Hispanic Black (NHB), Hispanic, Asian/Pacific Islander (API), American Indian/Alaskan Native (AIAN) vs. non-Hispanic White (NHW) patients, particularly in Hispanic or API subgroups. METHODS: Patient diagnosed between 2004 and 2020 with low grade (LG)-endometrioid endometrial cancer (ECC) or an aggressive EC including grade 3 EEC, serous carcinoma, clear cell carcinoma, mixed epithelial carcinoma, or carcinosarcoma in the National Cancer Database were studied...
January 25, 2024: Gynecologic Oncology
https://read.qxmd.com/read/38256351/rate-of-vaginal-cuff-dehiscence-when-using-vicryl-poliglactyn-910-compared-to-pds-polydioxanone-for-vaginal-cuff-closure-in-laparoscopic-hysterectomy
#11
JOURNAL ARTICLE
Francesco Giuseppe Cannone, Livia Cormaci, Carla Ettore, Ferdinando Antonio Gulino, Giosuè Giordano Incognito, Domenico Benvenuto, Giuseppe Ettore
Objective: To compare the vaginal cuff dehiscence (VCD) rates using Vicryl (Poliglactyn 910) and Polydioxanone (PDS) in patients who underwent laparoscopic hysterectomy. Materials and methods: A retrospective, monocentric study was conducted, including all patients undergoing laparoscopic hysterectomy at the Department of Obstetrics and Gynaecology, Azienda di Rilievo Nazionale e di Alta Specializzazione (ARNAS) Garibaldi Nesima, Catania, between January 2014 and December 2021. Patients underwent hysterectomy for benign gynecologic pathologies (endometriosis, leiomyomas, or benign pelvic pathologies) or malignant gynecologic pathologies (endometrium cancer, complex endometrial hyperplasia, ovarian cancer, cervix cancer, or uterine carcinosarcoma)...
January 3, 2024: Medicina
https://read.qxmd.com/read/38234609/comprehensive-analysis-and-immunohistochemistry-localization-of-nrp1-expression-in-pancancer-and-normal-individual-tissues-in-relation-to-sars%C3%A2-cov%C3%A2-2-susceptibility
#12
JOURNAL ARTICLE
Jiewen Fu, Jiayue He, Lianmei Zhang, Jingliang Cheng, Pengfei Zhang, Chunli Wei, Junjiang Fu, Dabing Li
Neuropilin 1 (NRP1/CD304) is a typical membrane-bound co-receptor for vascular endothelial growth factor, semaphorin family members and viral severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, NRP1 expression levels across cancer types and the potential role of SARS-CoV-2 infection in patients with cancer are not clear. Online databases, such as The Cancer Genome Atlas database of Human Protein Atlas, Gene Expression Profiling Interactive Analysis and cBioPortal were used for the expression analysis in this study...
February 2024: Experimental and Therapeutic Medicine
https://read.qxmd.com/read/38182153/uterine-carcinosarcoma-presenting-as-metastatic-osteosarcoma-in-the-lung-a-case-report-and-literature-review
#13
JOURNAL ARTICLE
Sara E Amin, Shaimaa Elzamly, Ahmed A Ahmed, Nidhi Tandon
Uterine carcinosarcomas (UCS) are aggressive tumors characterized by their biphasic nature, consisting of high-grade epithelial and mesenchymal elements. One component may predominate over the other. We present the case of a 59-year-old female who initially received a diagnosis of endometrial serous carcinoma and presented one year later with a malignant neoplasm in the lung featuring osteosarcomatous differentiation. Notably, the bone scan did not reveal any evidence of a primary bone tumor. However, additional sampling from the endometrium demonstrated a UCS with an osteosarcomatous component...
November 2023: Annals of Clinical and Laboratory Science
https://read.qxmd.com/read/38154864/uterine-carcinosarcoma-showing-immature-teratoid-like-differentiation
#14
JOURNAL ARTICLE
Mio Naito, Mika Terasaki, Nozomi Ouchi, Masafumi Toyoshima
A carcinosarcoma is a rare form of cancer characterised by the presence of both carcinomatous and sarcomatous components. Here, we present our experience with an extremely rare case of an uterine carcinosarcoma with immature teratoid-like differentiation. The patient was a woman in her 60s. She was referred for the evaluation of a uterine tumour. She underwent total abdominal hysterectomy with bilateral adnexectomy and received postoperative treatment with paclitaxel and carboplatin. On microscopic examination, the tumour had a heterogeneous appearance with a combination of carcinomatous and sarcomatous elements, and teratoid features...
December 28, 2023: BMJ Case Reports
https://read.qxmd.com/read/38146588/comparative-analysis-of-ezh2-p16-and-p53-expression-in-uterine-carcinosarcomas
#15
JOURNAL ARTICLE
Evelin Makk, Noémi Bohonyi, Angéla Oszter, Klára Éles, Tamás Tornóczky, Arnold Tóth, Endre Kálmán, Krisztina Kovács
Introduction: The role of p16 and p53 immunohistochemistry in the diagnosis of rare and aggressive uterine carcinosarcoma (UCS) has been well established. However, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a member of the polycomb group family is a relatively new biomarker, with limited published data on its significance in this tumor type. The goal of this study was to examine EZH2 expression in UCS and its components, in correlation with morphological features, and p16 and p53 staining patterns...
2023: Pathology Oncology Research: POR
https://read.qxmd.com/read/38118271/assessment-of-oncological-safety-and-utility-of-hysteroscopy-in-high-grade-endometrial-cancers-results-from-an-israel-gynecologic-oncology-group-study
#16
JOURNAL ARTICLE
Ahmet Namazov, Limor Helpman, Ram Eitan, Zvi Vaknin, Ofer Lavie, Amnon Amit, Tally Levy, Inbar Ben Shachar, Ilan Atlas, Ilan Bruchim, Alon Ben Arie, Ofer Gemer
OBJECTIVE: To compare survival measures of women with Stage I high-grade endometrial cancer who underwent either hysteroscopy or a non-hysteroscopic procedure as a diagnostic procedure. STUDY DESIGN: 298 patients with stage I high grade endometrial cancer who underwent surgery between 2002 and 2014. Patients were divided into two groups: hysteroscopy and non-hysteroscopy (curettage or office endometrial biopsy). Clinical, pathological, and survival measures were compared between the groups...
February 2024: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38101828/epidemiology-site-specific-characteristics-and-survival-of-carcinosarcoma-a-retrospective-study-based-on-seer-database
#17
JOURNAL ARTICLE
Lian-Sha Tang, Yu-Wen Zhou, Jia-Ling Wang, Guo-Xu Zhang, Chen-Hao Xu, Ji-Yan Liu, Meng Qiu
OBJECTIVES: Carcinosarcoma (CS) is a rare and biphasic malignancy characterised by a highly invasive biological nature and poor prognosis. This study explored the epidemiology, site-specific characteristics and survival outcome of CS. DESIGN: We conducted a retrospective study in the Surveillance, Epidemiology and End Results (SEER) database (1975-2018) for primary CS. SETTING AND PARTICIPANTS: SEER database includes publicly available information from regional and state cancer registries in the US centres...
December 14, 2023: BMJ Open
https://read.qxmd.com/read/38086166/practice-patterns-time-trends-and-quality-of-care-of-uterine-cancer-in-belgium-an-analysis-of-the-effect-database
#18
JOURNAL ARTICLE
Joren Vanbraband, Nancy Van Damme, Geert Silversmit, Anke De Geyndt, Gauthier Bouche, Gerd Jacomen, Eric de Jonge, Frédéric Goffin, Hannelore Denys, Frédéric Amant
OBJECTIVES: To investigate the practice patterns and quality of care for uterine cancer on a national level in Belgium, including trends in practice over the period 2012-2016. METHODS: Quality indicators were measured using the EFFectiveness of Endometrial Cancer Treatment (EFFECT) database. Multivariable logistic mixed regression was used to test for associations between the quality indicators and year of diagnosis, adjusted for potential confounders and intra-cluster correlations...
December 11, 2023: Gynecologic Oncology
https://read.qxmd.com/read/38085958/preferentially-expressed-antigen-in-melanoma-expression-in-uterine-and-ovarian-carcinosarcomas
#19
JOURNAL ARTICLE
Alaaeddin Alrohaibani, Yun Yu, Lina Gao, Kimberly M McLean, Jonathon Hetts, Ozlen Saglam
Carcinosarcoma (CS) is an aggressive form of gynecologic malignancy that accounts for ~5% of carcinomas in the endometrium and ovaries. There has been no significant improvement in survival over the last decades despite additional treatment options. PReferentially Expressed Antigen in MElanoma (PRAME) is an immunotherapy target used for the treatment of several solid tumors. We explored the PRAME protein expression levels in ovarian and uterine CS (n = 29). The expression levels were recorded by H-score (percentage of positively stained cells multiplied by staining intensity) in carcinomatous and sarcomatous components separately and compared by paired t-test...
November 13, 2023: International Journal of Gynecological Pathology
https://read.qxmd.com/read/38085954/ovarian-mesonephric-like-adenocarcinoma-recurring-with-a-rhabdomyosarcoma-component-a-case-report
#20
JOURNAL ARTICLE
Akiko Yamamoto, Takeshi Nagai, Aoi Sukeda, Manami Kajiwara, Masaharu Fukunaga, Toru Sasaki, Yuta Kinoshita, Motoshige Hayashi, Shigehiro Hayashi, Masataka Ono, Masayuki Futagami, Hirotaka Nishi
Mesonephric-like adenocarcinoma (MLA) has recently been described as a tumor of the endometrium or ovaries, which, morphologically and immunohistochemically, resembles mesonephric adenocarcinoma arising mostly in the uterine cervix. Herein, we report, to our knowledge, the first case of ovarian MLA that developed into an extremely rapidly growing recurrent mesonephric-like carcinosarcoma, as confirmed by a genomic profiling test. A 51-year-old woman underwent chemotherapy with complete debulking surgery for ovarian carcinoma...
November 13, 2023: International Journal of Gynecological Pathology
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