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Uterine carcinosarcoma

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https://www.readbyqxmd.com/read/27921006/survival-and-control-prognosticators-of-recurrent-gynecological-malignancies-of-the-pelvis-and-para-aortic-region-treated-with-stereotactic-body-radiation-therapy
#1
Shaakir Hasan, Anthony Ricco, Kaylette Jenkins, Rachelle Lanciano, Alexandra Hanlon, John Lamond, Jun Yang, Jing Feng, Michael Good, Joel Noumoff, Luther Brady
PURPOSE: To define prognostic factors associated with improved survival and local control (LC) for gynecologic cancer recurrences limited to the pelvis and para-aortic (PA) region using stereotactic body radiation therapy (SBRT). METHODS: Between 2/2008 and 7/2014, 30 women (35 targets) with pelvic or PA recurrence of endometrioid (n = 12), cervical (n = 11), ovarian (n = 3), uterine-serous (n = 2), or carcinosarcoma (n = 2) cancer were treated with SBRT...
2016: Frontiers in Oncology
https://www.readbyqxmd.com/read/27905110/distinct-molecular-landscapes-between-endometrioid-and-non-endometrioid-uterine-carcinomas
#2
Nathaniel L Jones, Joanne Xiu, Sudeshna Chatterjee-Paer, Alexandre Buckley de Meritens, William M Burke, Ana I Tergas, Jason D Wright, June Y Hou
Endometrial carcinoma (EC) is traditionally characterized as endometrioid and non-endometrioid based on histo-pathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between March 2011 and July 2014: 1634 Type I and 1226 Type II. In situ hybridization and immunohistochemistry were used to assess copy number and protein expression of selected genes. Sequenced variants in 47 genes were analyzed using the Illumina TruSeq Amplicon Cancer Panel...
December 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27889902/establishment-and-characterization-of-a-novel-uterine-carcinosarcoma-cell-line-tu-ecs-1-with-mutations-of-tp53-and-kras
#3
Yohei Chiba, Seiya Sato, Hiroaki Itamochi, Yasuko Suga, Tomoyuki Fukagawa, Nao Oumi, Tetsuro Oishi, Tasuku Harada, Tamotsu Sugai, Toru Sugiyama
A new human uterine carcinosarcoma (UCS) cell line, TU-ECS-1, was established and characterized. The morphological appearance of the cultured cells was an insular of epithelial-like cells arranged in the form of a jigsaw puzzle and mesenchymal-like cells with a spindle-shaped or fibroblast-like morphology. A relatively high proliferation rate was observed with a doubling time of 18.2 h. The chromosome number ranged from 44 to 49 and had an extra chromosome 12 (trisomy 12). The respective half-maximal inhibitory concentrations of cisplatin, paclitaxel, and doxorubicin were 2...
November 26, 2016: Human Cell
https://www.readbyqxmd.com/read/27870704/clinical-outcomes-for-stereotactic-ablative-radiotherapy-in-oligometastatic-and-oligoprogressive-gynecological-malignancies
#4
Shane Mesko, Kiri Sandler, Joshua Cohen, Gottfried Konecny, Michael Steinberg, Mitchell Kamrava
OBJECTIVES: We report single-institution clinical outcomes of women treated with stereotactic ablative radiotherapy (SABR) for oligometastatic or progressive gynecological malignancies. MATERIALS AND METHODS: From 2009 to 2015, 47 lesions from 28 patients were treated with SABR and retrospectively analyzed. All patients had oligometastatic (93%) or oligoprogressive (7%) disease. Primary cancer diagnoses were 15 ovarian, 8 endometrial, 2 cervical, 2 vaginal, and 1 uterine carcinosarcoma...
November 17, 2016: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/27867926/a-case-of-solitary-brain-metastasis-from-uterine-mullerian-adenosarcoma-with-sarcomatous-overgrowth
#5
Suk Bo Hong, Min Jung Kim, Ji Yeon Kwon, Seok Jin Choi, Eun Young Kim, Joohan Lim
Uterine adenosarcoma (AS) are rare tumors and have more favorable outcomes than the aggressive uterine carcinosarcomas. Uterine adenosarcoma with sarcomatous overgrowth (ASSO) is a variant form of AS and exhibits aggressive growth of tumor and the prognosis is relatively poor compared with typical AS. Usually patterns of metastasis have been known to behave like endometrial carcinoma and spread through the lymphatics. Brain metastasis from uterine AS is extremely rare. Herein, we report a case of successfully surgically removed solitary brain metastasis without any extracranial recurrence from uterine ASSO after 4 years of primary treatment...
October 2016: Brain Tumor Research and Treatment
https://www.readbyqxmd.com/read/27833321/rare-case-of-an-ovarian-vein-tumor-thrombosis-identified-on-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#6
Piyush Chandra, Archi Agrawal, Nilendu Purandare, Sneha Shah, Venkatesh Rangarajan
Fludeoxyglucose positron emission tomography/computed tomography is valuable in the identification of tumor thrombus and differentiating it from bland thrombus which has implications in initiating anticoagulation. We present a rare case of tumor thrombosis in ovarian vein, in a recurrent case of uterine carcinosarcoma.
October 2016: Indian Journal of Nuclear Medicine: IJNM: the Official Journal of the Society of Nuclear Medicine, India
https://www.readbyqxmd.com/read/27794476/comprehensive-staging-of-uterine-carcinosarcoma-utilizing-a-multiquadrant-robotic-platform
#7
Thanh H Dellinger, Mark T Wakabayashi, Ernest S Han
OBJECTIVE: To demonstrate the feasibility of multi-quadrant staging of a uterine carcinosarcoma using the latest-generation robotic platform. DESIGN: Step-by-step explanation of the technique using videos and pictures (educative video). SETTING: While laparoscopic and robotic-assisted laparoscopic staging of high-risk uterine cancer is well incorporated into many gynecologic oncology practices, extensive para-aortic lymphadenectomies above the inferior mesenteric artery are less commonly performed...
October 26, 2016: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/27791010/mutational-landscape-of-uterine-and-ovarian-carcinosarcomas-implicates-histone-genes-in-epithelial-mesenchymal-transition
#8
Siming Zhao, Stefania Bellone, Salvatore Lopez, Durga Thakral, Carlton Schwab, Diana P English, Jonathan Black, Emiliano Cocco, Jungmin Choi, Luca Zammataro, Federica Predolini, Elena Bonazzoli, Mark Bi, Natalia Buza, Pei Hui, Serena Wong, Maysa Abu-Khalaf, Antonella Ravaggi, Eliana Bignotti, Elisabetta Bandiera, Chiara Romani, Paola Todeschini, Renata Tassi, Laura Zanotti, Franco Odicino, Sergio Pecorelli, Carla Donzelli, Laura Ardighieri, Fabio Facchetti, Marcella Falchetti, Dan-Arin Silasi, Elena Ratner, Masoud Azodi, Peter E Schwartz, Shrikant Mane, Roberto Angioli, Corrado Terranova, Charles Matthew Quick, Babak Edraki, Kaya Bilgüvar, Moses Lee, Murim Choi, Amy L Stiegler, Titus J Boggon, Joseph Schlessinger, Richard P Lifton, Alessandro D Santin
Carcinosarcomas (CSs) of the uterus and ovary are highly aggressive neoplasms containing both carcinomatous and sarcomatous elements. We analyzed the mutational landscape of 68 uterine and ovarian CSs by whole-exome sequencing. We also performed multiregion whole-exome sequencing comprising two carcinoma and sarcoma samples from six tumors to resolve their evolutionary histories. The results demonstrated that carcinomatous and sarcomatous elements derive from a common precursor having mutations typical of carcinomas...
October 25, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27779297/expression-of-aurora-kinases-predictor-of-tumor-dissemination-in-uterine-carcinosarcoma
#9
Kyung Hee Han, Min A Kim, Noh Hyun Park
Uterine carcinosarcoma is a rare, aggressive, and biphasic tumor. It comprises carcinomatous and sarcomatous components, and mitosis-associated factors are thought to discriminate these two lesions. Aurora kinases are mitotic enzymes that are highly expressed in uterine malignancies. To identify the clinical significance of aurora kinase expression, we performed immunohistochemistry on tissue microarrays using cores selected from areas with typical carcinomatous and sarcomatous characteristics. A total of 24 samples were included, from patients at Seoul National University Hospital diagnosed with uterine carcinosarcoma, and who undergone a staging operation between 1997 and 2012...
October 25, 2016: Histology and Histopathology
https://www.readbyqxmd.com/read/27776011/uterine-serous-carcinomas-frequently-metastasize-to-the-fallopian-tube-and-can-mimic-serous-tubal-intraepithelial-carcinoma
#10
Friedrich Kommoss, Asma Faruqi, C Blake Gilks, Sarah Lamshang Leen, Naveena Singh, Nafisa Wilkinson, W Glenn McCluggage
We investigated the frequency, histopathologic, and immunohistochemical characteristics of tubal involvement in uterine serous carcinoma (USC) and aimed to clarify the relationship between "serous tubal intraepithelial carcinoma (STIC)" and USC in these cases. Cases of USC with complete tubal examination were prospectively collected and reviewed for the presence of tubal involvement. Immunohistochemical analysis for p53 and WT1 was performed on the endometrial and tubal tumor in cases with tubal involvement...
October 21, 2016: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/27761279/predictive-and-prognostic-factors-in-ovarian-and-uterine-carcinosarcomas
#11
İrfan Cicin, Tahsin Özatlı, Esma Türkmen, Türkan Özturk, Melike Özçelik, Devrim Çabuk, Ayşe Gökdurnalı, Özlem Balvan, Yaşar Yıldız, Metin Şeker, Nuriye Özdemir, Burcu Yapar, Özgür Tanrıverdi, Yusuf Günaydin, Serkan Menekşe, Berna Öksüzoğlu, Asude Aksoy, Bülent Erdogan, M Bekir Hacıoglu, Erkan Arpaci, Alper Sevinç
BACKGROUND: Prognostic factors and the standard treatment approach for gynaecological carcinosarcomas have not yet been clearly defined. Although carcinosarcomas are more aggressive than pure epithelial tumours, they are treated similarly. Serous/clear cell and endometrioid components may be predictive factors for the efficacy of adjuvant chemotherapy (CT) or radiotherapy (RT) or RT in patients with uterine and ovarian carcinosarcomas. Heterologous carcinosarcomas may benefit more from adjuvant CT...
September 2016: Balkan Medical Journal
https://www.readbyqxmd.com/read/27743738/impact-of-histology-and-surgical-approach-on-survival-among-women-with-early-stage-high-grade-uterine-cancer-an-nrg-oncology-gynecologic-oncology-group-ancillary-analysis
#12
Amanda N Fader, James Java, Meaghan Tenney, Stephanie Ricci, Camille C Gunderson, Sarah M Temkin, Nick Spirtos, Christina L Kushnir, Michael L Pearl, Oliver Zivanovic, Krishnansu S Tewari, David O'Malley, Ellen M Hartenbach, Chad A Hamilton, Natalie S Gould, Robert S Mannel, William Rodgers, Joan L Walker
OBJECTIVES: We sought to analyze the clinicopathologic features, recurrence patterns and survival outcomes of women with high-grade uterine cancer (UC) enrolled on The Gynecologic Oncology Group (GOG) LAP2 trial. METHODS: This is a post-hoc analysis of LAP-2 patients with grade 3 endometrioid adenocarcinoma (ENDO), uterine serous (USC), clear cell (CC) and carcinosarcoma (CS). Demographics, clinicopathologic features, and recurrence patterns, were compared by histology and surgical approach...
December 2016: Gynecologic Oncology
https://www.readbyqxmd.com/read/27738815/-new-features-in-the-2014-who-classification-of-uterine-neoplasms
#13
S F Lax
The 2014 World Health Organization (WHO) classification of uterine tumors revealed simplification of the classification by fusion of several entities and the introduction of novel entities. Among the multitude of alterations, the following are named: a simplified classification for precursor lesions of endometrial carcinoma now distinguishes between hyperplasia without atypia and atypical hyperplasia, the latter also known as endometrioid intraepithelial neoplasia (EIN). For endometrial carcinoma a differentiation is made between type 1 (endometrioid carcinoma with variants and mucinous carcinoma) and type 2 (serous and clear cell carcinoma)...
October 13, 2016: Der Pathologe
https://www.readbyqxmd.com/read/27703679/prognostic-impact-of-primary-tumor-suvmax-on-preoperative-18-f-fluoro-2-deoxy-d-glucose-positron-emission-tomography-and-computed-tomography-in-endometrial-cancer-and-uterine-carcinosarcoma
#14
Tamaki Yahata, Shigetaka Yagi, Yasushi Mabuchi, Yuko Tanizaki, Aya Kobayashi, Madoka Yamamoto, Mika Mizoguchi, Sakiko Nanjo, Michihisa Shiro, Nami Ota, Sawako Minami, Masaki Terada, Kazuhiko Ino
The objective of the present study was to investigate the usefulness of the maximum standardized uptake value (SUVmax) of the primary tumor on preoperative (18)F-fluoro-2-deoxy-D-glucose (FDG) positron emission tomography and computed tomography (PET/CT) as a prognostic indicator in patients with endometrial neoplasms. A total of 75 patients with endometrial cancer or uterine carcinosarcoma who underwent surgical treatment were included in the present study. All patients underwent preoperative PET/CT, and the correlation between the SUVmax of the primary tumor and clinical outcomes was analyzed...
October 2016: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/27675941/national-cancer-data-base-analysis-of-uterine-carcinosarcoma-uc-improvement-in-survival-with-the-use-of-radiation-therapy
#15
E M Nichols, S M Bentzen, D Scartoni, I Giacomelli, D M Roque, G Rao, N Hanna, P Mohindra
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674308/chemoradiation-versus-chemotherapy-in-uterine-carcinosarcoma-patterns-of-care-and-impact-on-overall-survival
#16
B Odei, D Boothe, D K Gaffney
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27674290/utilization-of-adjuvant-chemotherapy-radiation-therapy-or-combined-modality-therapy-and-the-impact-on-survival-for-uterine-carcinosarcoma
#17
A T Wong, D Schwartz, A Lee, M Shao, P Y Han, D Schreiber
No abstract text is available yet for this article.
October 1, 2016: International Journal of Radiation Oncology, Biology, Physics
https://www.readbyqxmd.com/read/27550404/clinical-significance-of-radiotherapy-in-patients-with-primary-uterine-carcinosarcoma-a-multicenter-retrospective-study-krog-13-08
#18
Jihye Cha, Young Seok Kim, Won Park, Hak Jae Kim, Joo Young Kim, Jin Hee Kim, Juree Kim, Won Sup Yoon, Jun Won Kim, Yong Bae Kim
OBJECTIVE: To investigate the role of radiotherapy (RT) in patients who underwent hysterectomy for uterine carcinosarcoma (UCS). METHODS: Patients with the International Federation of Gynecology and Obstetrics stage I-IVa UCS who were treated between 1990 and 2012 were identified retrospectively in a multi-institutional database. Of 235 identified patients, 97 (41.3%) received adjuvant RT. Twenty-two patients with a history of previous pelvic RT were analyzed separately...
November 2016: Journal of Gynecologic Oncology
https://www.readbyqxmd.com/read/27485451/recurrent-ppp2r1a-mutations-in-uterine-cancer-act-through-a-dominant-negative-mechanism-to-promote-malignant-cell-growth
#19
Dorien Haesen, Layka Abbasi Asbagh, Rita Derua, Antoine Hubert, Stefanie Schrauwen, Yana Hoorne, Frédéric Amant, Etienne Waelkens, Anna Sablina, Veerle Janssens
Somatic missense mutations in the Ser/Thr protein phosphatase 2A (PP2A) Aα scaffold subunit gene PPP2R1A are among the few genomic alterations that occur frequently in serous endometrial carcinoma (EC) and carcinosarcoma, two clinically aggressive subtypes of uterine cancer with few therapeutic options. Previous studies reported that cancer-associated Aα mutants exhibit defects in binding to other PP2A subunits and contribute to cancer development by a mechanism of haploinsufficiency. Here we report on the functional significance of the most recurrent PPP2R1A mutations in human EC, which cluster in Aα HEAT repeats 5 and 7...
October 1, 2016: Cancer Research
https://www.readbyqxmd.com/read/27453926/performance-of-sentinel-lymph-node-biopsy-in-high-risk-endometrial-cancer
#20
Jessie Ehrisman, Angeles Alvarez Secord, Andrew Berchuck, Paula S Lee, Nicola Di Santo, Micael Lopez-Acevedo, Gloria Broadwater, Fidel A Valea, Laura J Havrilesky
OBJECTIVE: To determine the rate and performance of sentinel lymph node (SLN) mapping among women with high-risk endometrial cancers. METHODS: Patients diagnosed between 2012 and 2015 with uterine cancer of grade 3 endometrioid, clear cell, serous or carcinosarcoma histology and who underwent SLN mapping prior to full pelvic lymph node dissection were included. Subjects underwent methylene blue or ICG injection for laparoscopic (N = 16) or robotic-assisted laparoscopic (N = 20) staging...
August 2016: Gynecologic Oncology Reports
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