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https://www.readbyqxmd.com/read/27910234/luminal-contents-from-the-gut-of-colicky-infants-induce-visceral-hypersensitivity-in-mice
#1
H Eutamène, C L Garcia-Rodenas, S Yvon, E d'Aldebert, F Foata, B Berger, J Sauser, V Theodorou, G Bergonzelli, E Mas
BACKGROUND: The pathophysiology of infantile colic is poorly understood, though various studies report gut microbiota dysbiosis in colicky infants. We aimed to test the hypothesis that colic-related dysbiosis is associated with visceral hypersensitivity triggered by an altered luminal milieu. METHODS: Fecal samples from seven colicky and seven non-colicky infants were studied. Fecal supernatants (FS) were infused into the colons of C57/Bl6 mice (n=10/specimen). Visceral sensitivity was subsequently assessed in the animals by recording their abdominal muscle response to colorectal distension (CRD) by electromyography (EMG)...
December 1, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27900948/prediction-of-antiepileptic-drug-treatment-outcomes-using-machine-learning
#2
Sinisa Colic, Robert G Wither, Min Lang, Liang Zhang, James H Eubanks, Berj L Bardakjian
OBJECTIVE: Antiepileptic drug (AED) treatments produce inconsistent outcomes, often necessitating patients to go through several drug trials until a successful treatment can be found. This study proposes the use of machine learning techniques to predict epilepsy treatment outcomes of commonly used AEDs. APPROACH: Machine learning algorithms were trained and evaluated using features obtained from intracranial electroencephalogram (iEEG) recordings of the epileptiform discharges observed in Mecp2-deficient mouse model of the Rett Syndrome...
November 30, 2016: Journal of Neural Engineering
https://www.readbyqxmd.com/read/27885827/a-mathematical-modeling-approach-to-understanding-the-effect-of-anti-interleukin-therapy-on-eosinophils
#3
T Karelina, V Voronova, O Demin, G Colice, B M Agoram
Emerging T-helper type 2 (Th2 ) cytokine-based asthma therapies, such as tralokinumab, lebrikizumab (anti-interleukin (IL)-13), and mepolizumab (anti-IL-5), have shown differences in their blood eosinophil (EOS) response. To better understand these effects, we developed a mathematical model of EOS dynamics. For the anti-IL-13 therapies, lebrikizumab and tralokinumab, the model predicted an increase of 30% and 10% in total and activated EOS in the blood, respectively, and a decrease in the total and activated EOS in the airways...
November 2016: CPT: Pharmacometrics & Systems Pharmacology
https://www.readbyqxmd.com/read/27885696/pharmacokinetics-of-oral-terbinafine-in-adult-horses
#4
T J Younkin, E G Davis, B Kukanich
The primary study objective was to compare the pharmacokinetics of p.o. terbinafine alone to p.o. terbinafine administered with p.o. cimetidine in healthy adult horses. The second objective was to assess the pharmacokinetics of terbinafine when administered per rectum in two different suspensions at 30 mg/kg to adult horses. Six healthy adult horses were included in this crossover study. Plasma terbinafine concentrations were quantified with liquid chromatography and mass spectrometry. The half-life (geometric mean) was 8...
November 24, 2016: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/27885297/mimicker-of-renal-colic-mesenteric-panniculitis
#5
A Canan
A Mesenteric panniculitis is an uncommon disorder with unknown etiology. It may cause nonspesific abdominal or systemic symptoms. Radiological modalitis especially computed tomography are very helpful to make a diagnosis. Hence, the radiologist should be familiar with its tomographic findings to avoid further examinations and unnecessary surgery. We report computed tomography findings of mesenteric panniculitis in an adult patient with renal colic.
May 2016: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/27878755/double-pigtail-stent-insertion-for-healing-of-leaks-following-roux-en-y-gastric-bypass-our-experience-with-videos
#6
Gianfranco Donatelli, Jean-Loup Dumont, Parag Dhumane, Stavros Dritsas, Thierry Tuszynski, Bertrand Marie Vergeau, Bruno Meduri
BACKGROUND: Roux-en-Y gastric bypass (RYGB) is complicated by a leak in 0-4.3% of cases. Treatment by fully covered stents has been reported to be associated with some life-threatening complications. We report our experience of insertion of double pigtail stents. METHODS: Thirty-three patients (20M, 43 years-20/65), presenting with a leak at an average of 10 days after RYGB (4-35), were treated by double pigtail stent insertion and a nasojejunal feeding tube. Sixty percent of these patients had undergone surgical drainage prior to stenting for control of sepsis...
November 23, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27878116/minijfil%C3%A2-a-new-safe-and-effective-stent-for-well-tolerated-repeated-extracorporeal-shockwave-lithotripsy-or-ureteroscopy-for-medium-to-large-kidney-stones
#7
Benoit Vogt, Francois-Noel Desfemmes, Arnaud Desgrippes, Yves Ponsot
BACKGROUND: Percutaneous nephrolithotomy (PCNL) is recommended for treating staghorn stones or stones measuring > 20 mm. Extracorporeal shockwave lithotripsy (ESWL) or flexible ureteroscopy (URS) may be used as a complement. However, PCNL can cause trauma to the kidney parenchyma, and patients may find a noninvasive procedure, such as ESWL, to be more attractive. OBJECTIVES: The aim of this study was to evaluate the clinical efficiency of MiniJFil® stenting associated with ESWL or second-line URS for the treatment of medium-to-large kidney stones...
September 2016: Nephro-urology Monthly
https://www.readbyqxmd.com/read/27875102/obesity-increases-operative-time-in-children-undergoing-laparoscopic-cholecystectomy
#8
T K Pandian, Daniel S Ubl, Elizabeth B Habermann, Christopher R Moir, Michael B Ishitani
INTRODUCTION: Few studies have assessed the impact of obesity on laparoscopic cholecystectomy (LC) in pediatric patients. MATERIALS AND METHODS: Children who underwent LC were identified from the 2012 to 2013 American College of Surgeons' National Surgical Quality Improvement Program Pediatrics data. Patient characteristics, operative details, and outcomes were compared. Multivariable logistic regression was utilized to identify predictors of increased operative time (OT) and duration of anesthesia (DOAn)...
November 22, 2016: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/27868102/case-report-of-percutaneous-tract-seeding-of-renal-pelvic-tumor-8-year-journey
#9
Paulos Yohannes
A 58-year-old female presented with renal colic and was found to have renal transitional cell carcinoma at the time of percutaneous surgery. She developed percutaneous tract seeding that clinically presented as subcutaneous skin nodules. After local treatment with surgical excision and radiation treatment, the patient developed retroperitoneal recurrence 5 years later. Percutaneous tract seeding is rare. There is no general consensus on prevention of tract seeding during percutaneous resection of renal urothelial tumors...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27868091/aftermath-of-grade-3-ureteral-injury-from-passage-of-a-ureteral-access-sheath-disaster-or-deliverance
#10
Roshan M Patel, Zhamshid Okhunov, Kamaljot Kaler, Ralph V Clayman
Background: The ureteral access sheath (UAS) has revolutionized the management of urinary pathology in the upper tract by providing rapid repeatable access to the upper urinary tract. However, in many practices, it remains a controversial tool in endourology given concerns of possible ureteral injury and presumed long-term sequela from those injuries. This case suggests that these concerns may be more hypothetical than real. Case Presentation: A 32-year-old female with a history of recurrent nephrolithiasis presented with left-sided symptomatic renal colic...
2016: Journal of Endourology Case Reports
https://www.readbyqxmd.com/read/27864726/hand-assisted-laparoscopic-right-hemicolectomy-with-complete-mesocolic-excision-and-central-vascular-ligation-a-novel-technique-for-right-colon-cancer
#11
Qing-Bin Wu, Xiang-Bing Deng, Xu-Yang Yang, Bing-Chen Chen, Wan-Bin He, Tao Hu, Ming-Tian Wei, Zi-Qiang Wang
BACKGROUND: It can be difficult to locate the superior mesenteric vein and dissect around middle colic vessels during laparoscopic right hemicolectomy with complete mesocolon excision due to a high rate of vascular variations in the superior mesenteric vessels. Therefore, we report a modified technique for hand-assisted laparoscopic right hemicolectomy with complete mesocolic excision and central vascular ligation, which addresses these two problems. METHODS: Thirty-one consecutive patients with right colon cancer underwent this procedure from March 2014 to August 2015...
November 18, 2016: Surgical Endoscopy
https://www.readbyqxmd.com/read/27864641/an-open-prospective-single-cohort-multicenter-study-evaluating-the-novel-tapered-conical-connection-implants-supporting-single-crowns-in-the-anterior-and-premolar-maxilla-interim-1-year-results
#12
Alexander Fügl, Werner Zechner, Alessandro Pozzi, Guido Heydecke, Christine Mirzakhanian, Nikolaus Behneke, Alexandra Behneke, Russell A Baer, Robert Nölken, Edward Gottesman, Snjezana Colic
OBJECTIVES: The aim of this multicenter prospective clinical study was to evaluate anodized tapered implants with a conical connection and integrated platform shifting placed in the anterior and premolar maxilla. MATERIALS AND METHODS: The study enrolled patients requiring single-tooth restorations in healed sites of maxillary anterior and premolar teeth. All implants were immediately temporized. Clinical and radiographic evaluations were conducted at implant insertion, 6 months, and 1 year...
November 18, 2016: Clinical Oral Investigations
https://www.readbyqxmd.com/read/27861920/comparison-of-computed-tomographic-angiography-and-intraoperative-mesenteric-portovenography-for-extrahepatic-portosystemic-shunts
#13
A T Parry, R N White
OBJECTIVES: Comparison of intra-operative mesenteric portovenography and computed tomographic angiography for the documentation of the portal vasculature in patients with single extrahepatic portosystemic shunts. METHODS: Retrospective study of patients with extrahepatic portosystemic shunts that underwent preoperative computed tomographic angiography and intra-operative mesenteric portography. Studies were compared for identification of the intra- and extrahepatic portal vasculature...
November 14, 2016: Journal of Small Animal Practice
https://www.readbyqxmd.com/read/27856357/clinical-effectiveness-in-the-diagnosis-and-acute-management-of-pediatric-nephrolithiasis
#14
REVIEW
Jason P Van Batavia, Gregory E Tasian
The incidence of pediatric nephrolithiasis has risen over the past few decades leading to a growing public health burden. Children and adolescents represent a unique patient population secondary to their higher risks from radiation exposure as compared to adults, high risk of recurrence, and longer follow up time given their longer life expectancies. Ultrasound imaging is the first-line modality for diagnosing suspected nephrolithiasis in children. Although data is limited, the best evidence based medicine supports the use of alpha-blockers as first-line MET in children, especially when stones are small and in a more distal ureteral location...
November 14, 2016: International Journal of Surgery
https://www.readbyqxmd.com/read/27855456/-gallstones-causes-and-consequences
#15
Katharina C Grotemeyer, Frank Lammert
Gallstones and their complications are one of most frequent gastroenterological diseases leading to hospital admission in Europe. Cholesterol stones are the most common; except of few patients there is a direct link to lifestyle. Obesity, diabetes and insufficient physical activity represent the major risk factors. Abdominal ultrasound is the gold standard for detection of gallstones. ERCP is indicated only in the therapeutic setting. In case of symptomatic gallbladder stones as well as bile duct stones, cholecystectomy is necessary...
November 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27847336/mexican-arnica-heterotheca-inuloides-cass-asteraceae-astereae-ethnomedical-uses-chemical-constituents-and-biological-properties
#16
REVIEW
José Luis Rodríguez-Chávez, Verónica Egas, Edelmira Linares, Robert Bye, Tzasna Hernández, Francisco J Espinosa-García, Guillermo Delgado
ETHNOPHARMACOLOGICAL RELEVANCE: Heterotheca inuloides Cass. (Asteraceae) has been traditionally used to treat a wide range of diseases in Mexico in the treatment of rheumatism, topical skin inflammation, muscular pain colic, and other painful conditions associated with inflammatory processes, additionally has been used to treat dental diseases, and gastrointestinal disorders. This species has also been used for the treatment of cancer and diabetes. This review provides up-to-date information on the botanical characterization, traditional uses, chemical constituents, as well as the biolological activities of H...
November 12, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27842733/timing-of-unplanned-admission-following-daycare-laparoscopic-cholecystectomy
#17
N Seyednejad, M Goecke, D E Konkin
BACKGROUND: Outpatient laparoscopic cholecystectomy is the treatment of choice for symptomatic biliary colic. There is controversy regarding the optimal candidate, and postoperative observation time for patients receiving daycare laparoscopic cholecystectomy. METHODS: A retrospective, multi-centred, case-control chart review was performed from January 1, 2009 to December 31, 2011 on consecutive patients undergoing planned laparoscopic cholecystectomy. Patient demographics, surgical details, and postoperative details were analyzed...
November 5, 2016: American Journal of Surgery
https://www.readbyqxmd.com/read/27842551/evaluation-of-the-use-of-swedish-integrated-electronic-health-records-and-register-health-care-data-as-support-clinical-trials-in-severe-asthma-the-pacehr-study
#18
Stefan Franzén, Christer Janson, Kjell Larsson, Max Petzold, Urban Olsson, Gunnar Magnusson, Gunilla Telg, Gene Colice, Gunnar Johansson, Mats Sundgren
BACKGROUND: In the development of new drugs for severe asthma, it is a challenge from an ethical point of view to randomize severe asthma patients to placebo, and to obtain long-term safety data due to discontinuations. The aim of this study was to evaluate the feasibility of using electronic health record (EHR) data to create a real-world reference population of uncontrolled asthmatic patients to supplement the concurrent control/placebo group in long-term studies of asthma. METHODS: EHR data from 36 primary care centres and a University hospital in Sweden were linked to Swedish mandatory health registers (2005-2013), creating a population covering 33 890 asthma patients, including data on co-morbidities, risk factors and laboratory/respiratory measurements...
November 15, 2016: Respiratory Research
https://www.readbyqxmd.com/read/27837415/evaluation-of-the-efficacy-of-sexual-intercourse-in-expulsion-of-distal-ureteric-stones
#19
Mohammad Sayed Abdel-Kader
OBJECTIVE: To evaluate the efficacy of sexual intercourse in expulsion of distal ureteric stones. PATIENTS AND METHODS: The study included 56 patients with distal ureteric or intramural stone. The stones size ranged from 5 to 10 mm and were detected by US, plain X-ray film, and non-enhanced CT. The patients were divided randomly into group A included 28 patients who were advised to do sexual intercourse 3-4 times/week with administration of symptomatic treatment, and group B included 28 patients receiving symptomatic treatment only (control group) and were instructed not to do sexual intercourse or masturbation during the study...
November 11, 2016: International Urology and Nephrology
https://www.readbyqxmd.com/read/27833955/neuro-neoplastic-interrelationships-in-colorectal-level-immunohistochemical-aspect-in-three-cases-and-review-of-the-literature
#20
Cristina Florescu, Octavian Istrătoaie, Georgică Costinel Târtea, Daniel Pirici, Costin Teodor Streba, Bogdan Cătălin, Ileana Puiu, Elena Anca Târtea, Daniel Cosmin Caragea, Mirela Corina Ghiluşi, Maria Victoria Comănescu, Ion Rogoveanu, Cristin Constantin Vere
Colorectal cancer represents a severe public health issue. Recent studies have shown the essential role played by nerves and their neurotransmitters in tumor initiation and progression. The aim of this study is to asses the expression of beta 2-adrenergic receptors (β2A) for adrenaline and noradrenaline, and the expression of M3 muscarinic receptors (M3R) for acetylcholine (neurotransmitters produced and released by sympathetic and parasympathetic afferents of the digestive tract and also by the enteric nervous system) in different tumor gradings of colorectal adenocarcinoma, and also the tropomyosin receptor kinase A (TrkA) for the nerve growth factor produced by the cells of colorectal adenocarcinoma...
2016: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
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