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https://www.readbyqxmd.com/read/29792288/tralokinumab-for-severe-uncontrolled-asthma-stratos-1-and-stratos-2-two-randomised-double-blind-placebo-controlled-phase-3-clinical-trials
#1
Reynold A Panettieri, Ulf Sjöbring, AnnaMaria Péterffy, Peter Wessman, Karin Bowen, Edward Piper, Gene Colice, Christopher E Brightling
BACKGROUND: Tralokinumab is an anti-interleukin-13 human monoclonal antibody developed for the treatment of severe, uncontrolled asthma. These clinical trials aimed to assess the efficacy and safety of tralokinumab in this population. METHODS: STRATOS 1 and STRATOS 2 were randomised, double-blind, parallel-group, placebo-controlled, phase 3 clinical trials that enrolled participants aged 12-75 years with severe asthma that was inadequately controlled despite use of inhaled corticosteroids (≥500 μg per day fluticasone or equivalent) and a long-acting β2 agonist (but not oral corticosteroids)...
May 18, 2018: Lancet Respiratory Medicine
https://www.readbyqxmd.com/read/29781067/rare-plasmacytoid-urothelial-carcinoma-of-the-bladder-two-case-reports
#2
Tuba Devrim, Fatih Atac, Canan Altunkaya, Ayse Ozbek, Gulhan Ozdemir, Merve Eryol
Plasmacytoid urothelial carcinoma is a rare and aggressive form of urothelial carcinoma characterized with delayed presentation and poor prognosis. Very few cases of this carcinoma have been reported in the literature. Here, we report and discuss two cases of bladder plasmacytoid urothelial carcinoma of a 57-year-old male presentedwith renal colic, and a 33-year-old female presented with macroscopic hematuria. Pathologic examinations of thetransurethral biopsies revealed urothelial carcinoma with plasmacytoid appearance...
May 21, 2018: Urology Journal
https://www.readbyqxmd.com/read/29775770/treatment-of-ruptured-vertebral-artery-dissection-and-abdominal-hemorrhage-associated-with-segmental-arterial-mediolysis-using-endovascular-coil-embolization-va-dissection-associated-with-sam
#3
Taiki Isaji, Tomotaka Ohshima, Sigeru Miyachi, Naoki Matsuo, Reo Kawaguchi, Masakazu Takayasu
BACKGROUND: Segmental arterial mediolysis is a rare disease characterized by idiopathic noninflammatory vasculopathy involving small to medium arteries. Here, we report a case of ruptured cerebral and abdominal aneurysms, which were successfully treated using emergency endovascular coil embolization. CASE DESCRIPTION: A 45-year-old male suffered subarachnoid hemorrhage caused by the rupture of the right vertebral artery dissecting aneurysm, which was treated using emergency endovascular coiling...
May 15, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29775451/-recurrent-urolithiasis-as-a-symptom-of-primary-hyperparathyroidism-in-a-16-year-old-boy
#4
Monika Wojciechowska, Beata Bieniaś, Aleksandra Sobieszczańska-Droździel, Anna Wieczorkiewicz-Płaza, Iwona Beń-Skowronek, Przemysław Sikora
Primary hyperparathyroidism is one of the most common endocrine diseases, however, it is rare in children. In most cases, it is caused by adenoma of these organs. Its most common complications include urolithiasis, nephrocalcinosis and osteoporosis. CASE REPORT: A 16-year-old patient was admitted to our Clinic because of his first-ever renal colic. The ultrasound examination revealed rightsided hydronephrosis caused by the presence of 9 mm stone in the upper part of the right ureter. In addition, the presence of 8 mm stone in the middle calyx of the left kidney was found...
April 23, 2018: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29772595/-case-report-metamizole-induced-agranulocytosis
#5
Falk A Gonnert, Winfried Meißner
Metamizole is primarily used for severe perioperative pain, acute injury and colic, and cancer pain. For other acute/chronic forms of pain and high fever, it should only be used if unresponsive to other agents. Metamizole should not be used for middle and low pain. Oral application should be preferred. A contraindication for metamizole is leukopenia. Clinical signs for agranulocytosis are fever, tonsillitis and aphthous stomatitis.
May 2018: Anästhesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie: AINS
https://www.readbyqxmd.com/read/29761687/emergency-extracorporeal-shockwave-lithotripsy-eswl-as-opposed-to-delayed-swl-dswl-for-the-treatment-of-acute-renal-colic-due-to-obstructive-ureteral-stone-a-prospective-randomized-trial
#6
Stefano Bucci, Paolo Umari, Michele Rizzo, Nicola Pavan, Giovanni Liguori, Fabio Barbone, Carlo Trombetta
BACKGROUND: To assess the efficacy of emergency extracorporeal shockwave lithotripsy (eSWL) as first-line treatment in patients with acute colic due to obstructive ureteral stone. METHODS: 74 patients were randomized to emergency SWL within 12 hours (eSWL group) and deferred SWL later than 3 days (dSWL group). Follow-up included ultrasound, KUB (Kidney-Ureter-Bladder) radiography and CT (computed tomography) scan at 24 hours, 7 days, 1 and 3 months from the treatment...
May 14, 2018: Minerva Urologica e Nefrologica, the Italian Journal of Urology and Nephrology
https://www.readbyqxmd.com/read/29760576/trends-of-gallbladder-cancer-in-jordan-over-2-decades-where-are-we
#7
Abdel Rahman Al Manasra, Mohammed Bani Hani, Haitham Qandeel, Samer Al Asmar, Mohammad Alqudah, Nabil Al-Zoubi, Satish Nadig, Shadi Hamouri, Khaled Obeidat, Nada Al-Muqaimi
Background and Study Aims: The prevalence of gallbladder cancer (GBC) varies between different parts of the world. This study is a review of literature and an update of a previously published study conducted in our university and aims to reassess the incidence of GBC over the past 2 decades. Patients and Methods: We conducted a retrospective study between 2002 and 2016. Data regarding demographics, clinical presentation, risk factors, histopathology, investigations, and treatments were obtained...
2018: Clinical Medicine Insights. Case Reports
https://www.readbyqxmd.com/read/29760502/infant-colic-mechanisms-and-management
#8
REVIEW
Judith Zeevenhooven, Pamela D Browne, Monique P L'Hoir, Carolina de Weerth, Marc A Benninga
Infant colic is a commonly reported phenomenon of excessive crying in infancy with an enigmatic and distressing character. Despite its frequent occurrence, little agreement has been reached on the definition, pathogenesis or the optimal management strategy for infant colic. This Review aims to delineate the definitional entanglement with the Rome IV criteria, which were published in 2016, as the leading, most recent diagnostic criteria. Moreover, neurogenic, gastrointestinal, microbial and psychosocial factors that might contribute to the pathophysiology of infant colic are explored...
May 14, 2018: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/29753276/impaction-of-swallowed-dentures-in-the-sigmoid-colon-requiring-sigmoid-colectomy
#9
Michael Flanagan, Cillian Clancy, Micheal G O Riordain
INTRODUCTION: Foreign body (FB) ingestion results in perforation in 1% of cases and is associated with significant morbidity and rarely mortality. Clinical presentation is variable and can present a diagnostic challenge. We report our experience and management of a patient with a delayed presentation of a sigmoid colon foreign body as a result of ingestion of a dental plate. PRESENTATION OF CASE: A 67 year old female attended the colorectal outpatient clinic following an incidental finding of a sigmoid mass on computed tomography (CT) abdomen...
May 7, 2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29747642/salivary-alpha-amylase-activity-and-cortisol-in-horses-with-acute-abdominal-disease-a-pilot-study
#10
María Dolores Contreras-Aguilar, Damián Escribano, María Martín-Cuervo, Fernando Tecles, Jose Joaquín Cerón
BACKGROUND: The aim of this study was to evaluate salivary alpha-amylase (sAA), considered a non-invasive biomarker for sympathetic nervous system (SNS) activity, and salivary cortisol as possible pain-induced stress biomarker, in horses with acute abdominal disease. Therefore, a prospective observational study was performed in which both biomarkers were analyzed in a group of horses with acute abdomen syndrome, and compared with a group of healthy control horses by an unpaired Student's t-test...
May 10, 2018: BMC Veterinary Research
https://www.readbyqxmd.com/read/29738008/does-fasting-in-ramadan-increase-the-risk-of-developing-urinary-stones
#11
Abdullah O Al Mahayni, Sultan S Alkhateeb, Ibrahim H Abusaq, Abdullah A Al Mufarrih, Muath I Jaafari, Amen A Bawazir
OBJECTIVES: To explore the frequency of renal colic (RC) secondary to urinary stones in Ramadan compared to other months and seasons of the year. METHODS: Retrospective cross-sectional study using medical records of 237 patients admitted through the emergency room (ER) with a diagnosis of RC secondary to urinary stones over a 10-year period at King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia. RESULTS: Patients fasting in Ramadan are 2 times more likely to present with a calculus of ureter as opposed to calculus in another location in the urinary tract, particularly when the holy month of Ramadan falls in the summer season...
May 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29737501/safety-of-tamsulosin-a-systematic-review-of-randomized-trials-with-a-focus-on-women-and-children
#12
REVIEW
Steven A Kaplan, Bilal I Chughtai
INTRODUCTION: Although tamsulosin is indicated for the treatment of the signs and symptoms of benign prostatic hyperplasia (BPH), it has also been assessed in clinical studies for other conditions/symptoms and in other populations such as women and children. In this systematic review of randomized studies, the overall safety of tamsulosin was assessed, focusing on these understudied populations. METHODS: Literature searches were conducted using Embase, Medline, and PubMed (inception-December 2015)...
May 8, 2018: Drug Safety: An International Journal of Medical Toxicology and Drug Experience
https://www.readbyqxmd.com/read/29729176/-comparative-characteristic-of-functional-gastrocerebral-disorders-in-donors-and-premature-infants
#13
Luydmila V Ignatko, Andriiana O Yankovska, Gabriela G Kavulya, Olena V Debretseni, Kristian O Debretseni, Nataliia M Hema-Bahyna, Agneta V Lenchenko
OBJECTIVE: Introduction: Functional gastrocerebral disorders (FGCD) occupy one of the leading places in the structure of diseases of digestive organs in young children. Functional gastrointestinal disorders are accompanied by various combinations of persistent or recurrent gastrointestinal symptoms without structural or biochemical disorders. They can accompany the normal development of the child and depend on organ's disorders on the background of autonomic dysfunction, psycho-emotional and humoral factors...
2018: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29727871/-thrombocytopenia-in-horses
#14
Emma Hübers, Natali Bauer, Kerstin Fey, Andreas Moritz, Katja Roscher
OBJECTIVE: The retrospective study aimed to evaluate the prevalence of true thrombocytopenia and ethylenediaminetetraacetic acid (EDTA)-induced pseudothrombocytopenia in horses and ponies and to assess the diagnostic and prognostic utility of true thrombocytopenia. MATERIAL AND METHODS: In 3592 patients (2008-2015) hematological data (ADVIA® 2120, Siemens) were reviewed. Inclusion criteria were platelet counts < 90 x 109/l (EDTA-blood) and/or < 84 x 109/l (citrate blood)...
April 2018: Tierärztliche Praxis. Ausgabe G, Grosstiere/Nutztiere
https://www.readbyqxmd.com/read/29724796/gad65-promoter-polymorphism-rs2236418-modulates-harm-avoidance-in-women-via-inhibition-excitation-balance-in-the-rostral-acc
#15
Lejla Colic, Meng Li, Liliana Ramona Demenescu, Shija Li, Iris Müller, Anni Richter, Constanze I Seidenbecher, Oliver Speck, Björn H Schott, Oliver Stork, Martin Walter
Anxiety disorders are common and debilitating conditions with higher prevalence in women. However, factors that predispose women to anxiety phenotypes are not clarified. Here we investigated potential contribution of the single nucleotide polymorphism rs2236418 in GAD2 gene to changes in regional inhibition/excitation balance, anxiety-like traits and related neural activity in both sexes. 105 healthy individuals were examined with high-field (7T) multimodal magnetic resonance imaging (MRI), including resting state fMRI in combination with assessment of GABA and Glutamate (Glu) levels via MR spectroscopy (MRS)...
May 3, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29724573/are-nonsteroidal-anti-inflammatory-drugs-safe-and-effective-for-treatment-of-acute-renal-colic
#16
EDITORIAL
Katie Pettit, Julie L Welch
No abstract text is available yet for this article.
April 30, 2018: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/29723117/hereditary-xanthinuria-is-not-so-rare-disorder-of-purine-metabolism
#17
I Sebesta, B Stiburkova, J Krijt
Hereditary xanthinuria (type I) is caused by an inherited deficiency of the xanthine oxidorectase (XDH/XO), and is characterized by very low concentration of uric acid in blood and urine and high concentration of urinary xanthine, leading to urolithiasis. Type II results from a combined deficiency of XDH/XO and aldehyde oxidase. Patients present with hematuria, renal colic, urolithiasis or even acute renal failure. Clinical symptoms are the same for both types. In a third type, clinically distinct, sulfite oxidase activity is missing as well as XDH/XO and aldehyde oxidase...
May 3, 2018: Nucleosides, Nucleotides & Nucleic Acids
https://www.readbyqxmd.com/read/29722730/virtual-reality-exploration-and-planning-for-precision-colorectal-surgery
#18
Ludovica Guerriero, Giuseppe Quero, Michele Diana, Luc Soler, Vincent Agnus, Jacques Marescaux, Francesco Corcione
BACKGROUND: Medical software can build a digital clone of the patient with 3-dimensional reconstruction of Digital Imaging and Communication in Medicine images. The virtual clone can be manipulated (rotations, zooms, etc), and the various organs can be selectively displayed or hidden to facilitate a virtual reality preoperative surgical exploration and planning. OBJECTIVE: We present preliminary cases showing the potential interest of virtual reality in colorectal surgery for both cases of diverticular disease and colonic neoplasms...
June 2018: Diseases of the Colon and Rectum
https://www.readbyqxmd.com/read/29710375/review-shows-that-parental-reassurance-and-nutritional-advice-help-to-optimise-the-management-of-functional-gastrointestinal-disorders-in-infants
#19
REVIEW
Silvia Salvatore, Abdelhak Abkari, Wei Cai, Anthony Catto-Smith, Sylvia Cruchet, Frederic Gottrand, Badriul Hegar, Carlos Lifschitz, Thomas Ludwig, Neil Shah, Annamaria Staiano, Hania Szajewska, Suporn Treepongkaruna, Yvan Vandenplas
AIM: Regurgitation, infantile colic and functional constipation are common functional gastrointestinal disorders (FGIDs) during infancy. Our aim was to provide carry out a concise review of the literature, evaluate the impact of these common FGIDs on infants and their families and provide an overview of national and international guidelines and peer-reviewed expert recommendations on their management. METHODS: National and international guidelines and peer-reviewed expert recommendations on the management of regurgitation, infantile colic, and functional constipation were examined and summarised...
April 30, 2018: Acta Paediatrica
https://www.readbyqxmd.com/read/29703365/probiotic-lactobacillus-reuteri-effective-in-treating-infantile-colic-and-is-associated-with-inflammatory-marker-reduction
#20
J Marc Rhoads
No abstract text is available yet for this article.
May 2018: Journal of Pediatrics
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