T Milivojac, M Grabež, A Krivokuća, U Maličević, M Gajić Bojić, Đ Đukanović, S Uletilović, N Mandić-Kovačević, T Cvjetković, M Barudžija, N Vojinović, A Šmitran, Lj Amidžić, M P Stojiljković, M Čolić, M Mikov, R Škrbić
Bacterial lipopolysaccharide (LPS) induces general inflammation, by activating pathways involving cytokine production, blood coagulation, complement system activation, and acute phase protein release. The key cellular players are leukocytes and endothelial cells, that lead to tissue injury and organ failure. The aim of this study was to explore the anti-inflammatory, antioxidant, and cytoprotective properties of two bile acids, ursodeoxycholic acid (UDCA) and chenodeoxycholic acid (CDCA) in LPS-induced endotoxemia in rats...
April 5, 2024: Molecular and Cellular Biochemistry