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https://www.readbyqxmd.com/read/29218495/systemic-epstein-barr-virus-positive-t-cell-lymphoproliferative-disorders-of-childhood-with-fulminant-leukocytosis-and-tumor-lysis-a-case-report-with-autopsy-findings
#1
Sachie Wada, Takayuki Suzuki, Koichi Kitazume, Akira Fujita, Seiichiro Shimizu
Systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (T-LPD) of childhood is an extremely rare disease characterized by an aggressive clinical course and very poor prognosis. We report an adolescent male with systemic EBV-positive T-LPD of childhood after primary EBV infection, resulting in a fatal clinical course within 9 days, along with autopsy findings. A 19-year-old male without an immunocompromised status presented with an acute onset of high fever, and was hospitalized for persistent fever, vomiting and diarrhea on the 5th day from onset...
December 7, 2017: International Journal of Hematology
https://www.readbyqxmd.com/read/29216953/-significance-of-heparin-in-the-treatment-of-patients-with-sepsis
#2
Qinlong Sun, Erzhen Chen
The latest definition of sepsis (Sepsis-3) is the life-threatening organ dysfunction due to overreaction of immune system caused by infection. The situation can develop into multiple organ dysfunction syndromes (MODS). In the pathological process of pathogen invasion, a large number of inflammatory factors directly damage organ function, while dysfunction of coagulation system is also involved in this process. With the overreaction of inflammation, disseminated intravascular coagulation (DIC) occurred, which further exacerbated organ damage...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29216936/-experimental-basis-and-clinical-practice-of-bacterial-poison-and-cure-sepsis
#3
Zhijun Li, Yinping Li
Since the 20th century, research team of Professor Wang Jinda in the Tianjin First Central Hospital has been using blood circulation drugs to rescue critically ill patients for 70 years. With the deepening of the understanding of sepsis, put forward the "bacteria and inflammation and governance" theory, and the use of blood circulation drugs Xuebijing injection with anti-endotoxin and inflammatory mediators effect in the treatment of sepsis, some clinical efficacy has been found. However, in recent years, the progress of treatment of sepsis at home and abroad is slow, we review a series of animal experiments since the late of 1980s, and found that small thrombosis in the microcirculation and coagulation disorders play a more important role in the development of local infection to sepsis transition...
December 2017: Zhonghua Wei Zhong Bing Ji Jiu Yi Xue
https://www.readbyqxmd.com/read/29212894/hiv-and-cardiovascular-disease-role-of-immunometabolic-perturbations
#4
REVIEW
Eman Teer, M Faadiel Essop
The successful rollout of anti-retroviral therapy ensured that HIV is increasingly managed as a chronic condition. HIV-positive persons are therefore exhibiting increased cardiovascular complications. This review focuses on the emerging role of "immunometabolism" within the context of HIV-related immune dysregulation and cardiovascular disease onset. Here, persistent immune activation contributes to pathophysiological perturbations during early infection, resulting in immune cell metabolic reprogramming and the activation of coagulation pathways in HIV-positive individuals...
January 1, 2018: Physiology
https://www.readbyqxmd.com/read/29202212/nebulized-heparin-attenuates-pulmonary-coagulopathy-and-inflammation-through-alveolar-macrophages-in-a-rat-model-of-acute-lung-injury
#5
Laura Chimenti, Marta Camprubí-Rimblas, Raquel Guillamat-Prats, Maria Nieves Gomez, Jessica Tijero, Lluis Blanch, Antonio Artigas
Objective Alveolar macrophages play a key role in the development and resolution of acute respiratory distress syndrome (ARDS), modulating the inflammatory response and the coagulation cascade in lungs. Anti-coagulants may be helpful in the treatment of ARDS. This study investigated the effects of nebulized heparin on the role of alveolar macrophages in limiting lung coagulation and inflammatory response in an animal model of acute lung injury (ALI). Methods Rats were randomized to four experimental groups...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29202211/acute-haemarthrosis-in-the-haemophilia-a-rat-generates-a-local-and-systemic-proinflammatory-response
#6
Karin M Lövgren, Kristine R Christensen, Wiktor Majewski, Olga Østrup, Søren Skov, Bo Wiinberg
Background Replacement therapy with coagulation factor VIII (FVIII) concurrent with bleeds (on-demand) in haemophilia A (HA) patients has been hypothesized to increase the risk for antidrug antibodies (inhibitors). A danger signal environment, characterized by tissue damage and inflammation at the site of a bleed, is thought to contribute to the anti-FVIII response. The nature of this inflammatory reaction is, however, not fully known, and new insights will be valuable for both managing inhibitors and understanding arthropathy development...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29202210/differential-effects-on-haemostatic-markers-by-metformin-and-the-contraceptive-pill-a-randomized-comparative-trial-in-pcos
#7
Genia F Burchall, Terrence J Piva, Sanjeeva Ranasinha, Helena J Teede
Background Polycystic ovarian syndrome (PCOS) affects up to 18% of reproductive-aged women with increased risks of cardiovascular disease and venous thromboembolic disease, related to metabolic and hormonal features, obesity and an apparent hypofibrinolytic state, possibly exacerbated by current PCOS treatments. Objective To investigate and compare haemostatic impacts of common pharmacological treatments and explore relationships with hormonal and metabolic variables in PCOS. Patients/Methods This mechanistic sub-study using biobanked samples from a 6-month randomized comparative trial of pharmacological treatments assessed pro- and anti-thrombotic markers and overall haemostatic activity...
November 2017: Thrombosis and Haemostasis
https://www.readbyqxmd.com/read/29193737/laboratory-testing-in-patients-treated-with-direct-oral-anticoagulants-a-practical-guide-for-clinicians
#8
REVIEW
Jonathan Douxfils, Walter Ageno, Charles-Marc Samama, Sarah Lessire, Hugo Ten Cate, Peter Verhamme, Jean-Michel Dogné, François Mullier
One of the key benefits of the direct oral anticoagulants (DOACs) is that they do not require routine laboratory monitoring. Nevertheless, assessment of DOAC exposure and anticoagulant effects may become useful in various clinical scenarios. The four approved DOACs - apixaban, dabigatran etexilate, edoxaban and rivaroxaban - have different characteristics impacting assay selection and the interpretation of results. This article provides an updated overview on 1) which test to use (and their advantages and limitations), 2) when to assay DOAC levels, 3) how to interpret the results relating to bleeding risk, emergency situations and perioperative management, and 4) what is the impact of DOACs on routine and specialised coagulation assays...
November 29, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29193703/inflammation-and-thrombosis-roles-of-neutrophils-platelets-and-endothelial-cells-and-their-interactions-in-thrombus-formation-during-sepsis
#9
REVIEW
Toshiaki Iba, Jerrold H Levy
The inflammatory response and the activation of coagulation are two important responses in a host's defense against infection. These mechanisms do not work independently but cooperate in a complex and synchronous manner. Recent research has also shed light on the critical role of thrombus formation that prevents the dissemination of microbes. The cellular components of blood vessels, leukocytes, platelets, erythrocytes, and vascular endothelial cells play significant roles in the development of thrombi in combination with activation of the coagulation system...
November 29, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/29189637/strategies-for-prevention-and-management-of-bleeding-following-pediatric-cardiac-surgery-on-cardiopulmonary-bypass-a-scoping-review
#10
Kristina Siemens, Dilanee P Sangaran, Beverley J Hunt, Ian A Murdoch, Shane M Tibby
OBJECTIVE: We aimed to systematically describe, via a scoping review, the literature reporting strategies for prevention and management of mediastinal bleeding post pediatric cardiopulmonary bypass surgery. DATA SOURCES: MEDLINE, EMBASE, PubMed, and Cochrane CENTRAL Register. STUDY SELECTION: Two authors independently screened publications from 1980 to 2016 reporting the effect of therapeutic interventions on bleeding-related postoperative outcomes, including mediastinal drain loss, transfusion, chest re-exploration rate, and coagulation variables...
November 16, 2017: Pediatric Critical Care Medicine
https://www.readbyqxmd.com/read/29189289/meibomian-glands-and-ocular-surface-changes-after-closure-of-meibomian-gland-orifices-in-rabbits
#11
Youngsub Eom, Ji Yun Han, Boram Kang, Ho Sik Hwang, Hyung Keun Lee, Hyo Myung Kim, Jong Suk Song
PURPOSE: To investigate changes in the corneal surface, tear film, and meibomian glands after meibomian gland orifice closure. METHODS: Seventy-two eyes of 36 rabbits were used. In the study group (n = 36), the meibomian gland orifices of both upper and lower eyelids in the right eyes were electrosurgically coagulated. The 36 untreated left eyes were used as controls. Corneal wetting properties were measured 1, 3, 7, and 14 days after coagulation. The eyelid sections were stained with anti-cytokeratin (CK)1, CK5, and CK6 antibody 8 weeks after coagulation...
November 16, 2017: Cornea
https://www.readbyqxmd.com/read/29182588/fluorinated-analog-nmr-s-of-organosulfur-compounds-from-garlic-allium-sativum-synthesis-chemistry-and-anti-angiogenesis-and-antithrombotic-studies
#12
Eric Block, Benjamin Bechand, Sivaji Gundala, Abith Vattekkatte, Kai Wang, Shaymaa S Mousa, Kavitha Godugu, Murat Yalcin, Shaker A Mousa
We describe the synthesis, reactivity, and antithrombotic and anti-angiogenesis activity of difluoroallicin (S-(2-fluoroallyl) 2-fluoroprop-2-ene-1-sulfinothioate) and S-2-fluoro-2-propenyl-l-cysteine, both easily prepared from commercially available 3-chloro-2-fluoroprop-1-ene, as well as the synthesis of 1,2-bis(2-fluoroallyl)disulfane, 5-fluoro-3-(1-fluorovinyl)-3,4-dihydro-1,2-dithiin, trifluoroajoene ((E,Z)-1-(2-fluoro-3-((2-fluoroallyl)sulfinyl)prop-1-en-1-yl)-2-(2-fluoroallyl)disulfane), and a bis(2-fluoroallyl)polysulfane mixture...
November 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29180933/implementation-of-an-enhanced-recovery-after-surgery-eras-protocol-in-a-gynaecology-department-the-follow-up-at-1-year
#13
Tomasz Nikodemski, Agnieszka Biskup, Aleksandra Taszarek, Małgorzata Albin, Anita Chudecka-Głaz, Aneta Cymbaluk-Płoska, Janusz Menkiszak
Aim of the study: An ERAS protocol provides the latest perioperative care principles, whose primary aim is to reduce complication rates, and therefore mortality. The aim of this study is to establish the progress of the ERAS pathway implementation in our gynaecology department. Material and methods: This was a retrospective analysis of two sets of 100 consecutive medical records: patients treated before (PRE-ERAS) and after (ERAS) introduction of the ERAS protocol...
2017: Contemporary Oncology Współczesna Onkologia
https://www.readbyqxmd.com/read/29174123/intraoperative-anesthetic-management-of-lung-transplantation-center-specific-practices-and-geographic-and-centers-size-differences
#14
Roland Tomasi, David Betz, Sophie Schlager, Tobias Kammerer, Dominik J Hoechter, Thomas Weig, Peter Slinger, Laura V Klotz, Bernhard Zwißler, Nandor Marczin, Vera von Dossow
OBJECTIVE: Although increasing evidence in lung transplantation (LTx) suggests that intraoperative management could influence outcomes, there are no guidelines available regarding intraoperative management of LTx. The overall goal of the study was to assess geographic and center volume-specific clinical practices in perioperative management. DESIGN: Prospective data analysis. SETTING: Online survey from a single-center university hospital...
May 17, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29172201/-effect-of-platelet-concentrate-transfusion-on-prognosis-of-patients-with-intracerebral-hemorrhage-treated-with-anti-platelet-agents
#15
Kazutaka Sugimoto, Hideyuki Ishihara, Mizuya Shinoyama, Hirokazu Sadahiro, Michiyasu Suzuki
BACKGROUND: A recent randomized control study(the PATCH trial)found no beneficial effect of platelet concentrate(PC)transfusion on the prognosis of patients with intracerebral hemorrhage(ICH)treated with anti-platelet agents(APAs). However, the trial excluded surgical cases. In this study, we examined the effect of PC on ICH, including patients who received surgical treatment. METHOD: A retrospective cohort analysis was performed in 23(11 males, 12 females)of 35 patients diagnosed with ICH and treated with APAs between January 2010 and December 2015 at the Department of Neurosurgery, Yamaguchi University Hospital...
November 2017: No Shinkei Geka. Neurological Surgery
https://www.readbyqxmd.com/read/29170301/4%C3%A2-the-risk-of-deterioration-in-ct-identified-mild-traumatic-brain-injury-a-systematic-review-and-meta-analysis
#16
Carl Marincowitz, Fiona Lecky, William Townend, Aditya Borakati, Trevor Sheldon
BACKGROUND: The optimal management of minor head injured patients with brain injury identified by CT imaging is unclear. Some guidelines recommend routine hospital admission of GCS13-15 patients with traumatic brain (TBI) injury identified by CT imaging. Others argue that selected lower-risk patients can be discharged from the Emergency Department (ED). OBJECTIVE: To estimate the risk of death, neurosurgery and clinical deterioration minor head injured patients with TBI identified by CT imaging, and assess which factors affect the risk of these outcomes...
December 2017: Emergency Medicine Journal: EMJ
https://www.readbyqxmd.com/read/29169118/characterization-of-a-microbial-polysaccharide-based-bioflocculant-and-its-anti-inflammatory-and-pro-coagulant-activity
#17
Chunying Zhong, Gang Cao, Kuan Rong, Zhengwu Xia, Ting Peng, Honggao Chen, Jiangang Zhou
We describe a novel bioflocculant, MBF-15, which is an exopolysaccharide extracted from the alkaliphilic bacterium Paenibacillus jamilae. The biophysical characteristics of MBF-15 were determined using Fourier transform infrared spectroscopy and X-ray photoelectron spectroscopy. MBF-15 was also evaluated for its biocompatibility by examining its inflammatory, coagulant, and hemostatic properties in vitro and in vivo. Pretreatment of peripheral blood mononuclear cells with MBF-15 inhibited lipopolysaccharide-stimulated expression of inducible nitric oxide synthase, production of nitric oxide, and secretion of pro-inflammatory cytokines, including tumor necrosis factor-α and interleukin-6...
November 16, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/29168733/single-shot-detection-of-neurotransmitters-in-whole-blood-samples-by-means-of-the-heat-transfer-method-in-combination-with-synthetic-receptors
#18
Thijs Vandenryt, Bart van Grinsven, Kasper Eersels, Peter Cornelis, Safira Kholwadia, Thomas J Cleij, Ronald Thoelen, Ward De Ceuninck, Marloes Peeters, Patrick Wagner
Serotonin is an important neurotransmitter that plays a major role in the pathogenesis of a variety of conditions, including psychiatric disorders. The detection of serotonin typically relies on high-performance liquid chromatography (HPLC), an expensive technique that requires sophisticated equipment and trained personnel, and is not suitable for point-of-care applications. In this contribution, we introduce a novel sensor platform that can measure spiked neurotransmitter concentrations in whole blood samples in a fast and low-cost manner by combining synthetic receptors with a thermal readout technique-the heat-transfer method...
November 23, 2017: Sensors
https://www.readbyqxmd.com/read/29166571/protective-cerebrovascular-effects-of-hydroxysafflor-yellow-a-hsya-on-ischemic-stroke
#19
Yang Sun, Dong-Ping Xu, Zhen Qin, Peng-Yuan Wang, Bo-Han Hu, Jian-Guang Yu, Yong Zhao, Ben Cai, Yong-Ling Chen, Min Lu, Jian-Guo Liu, Xia Liu
The purpose of the present work was designed to explore protective cerebrovascular effects of hydroxysafflor yellow A (HSYA), and provide preclinical efficacy and mechanism data for its possible application in patients with cerebral ischemia. The protective effect of HSYA on ischemic stroke was evaluated by infarct sizes and neurological scores in Sprague-Dawley (SD) rats with middle cerebral artery occlusion (MCAO). Cerebrovascular permeability was detected by Evans blue dye leakage in MCAO rats. Cerebral blood flow, as well as blood pressure and heart rate were monitored using flow probes in Beagle dogs...
November 19, 2017: European Journal of Pharmacology
https://www.readbyqxmd.com/read/29165355/acute-effects-of-nitrate-rich-beetroot-juice-on-blood-pressure-hemostasis-and-vascular-inflammation-markers-in-healthy-older-adults-a-randomized-placebo-controlled-crossover-study
#20
Kyle Raubenheimer, Danica Hickey, Michael Leveritt, Robert Fassett, Joaquin Ortiz de Zevallos Munoz, Jason D Allen, David Briskey, Tony J Parker, Graham Kerr, Jonathan M Peake, Natalie M Pecheniuk, Oliver Neubauer
Aging is associated with a vasoconstrictive, pro-coagulant, and pro-inflammatory profile of arteries and a decline in the bioavailability of the endothelium-derived molecule nitric oxide. Dietary nitrate elicits vasodilatory, anti-coagulant and anti-inflammatory effects in younger individuals, but little is known about whether these benefits are evident in older adults. We investigated the effects of 140 mL of nitrate-rich (HI-NI; containing 12.9 mmol nitrate) versus nitrate-depleted beetroot juice (LO-NI; containing ≤0...
November 22, 2017: Nutrients
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