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Marja Kaijomaa, Veli-Matti Ulander, Esa Hämäläinen, Henrik Alfthan, Helene Markkanen, Seppo Heinonen, Vedran Stefanovic
OBJECTIVE: To analyze the risk of adverse pregnancy outcome in three subgroups with extremely low maternal PAPP-A, i.e. < 0.3 multiples of median (MoM) at the first trimester screening. METHOD: A cohort of 961 pregnancies with PAPP-A levels < 0.3 MoM at the first trimester combined screening was followed up during the study period of January 2009-December 2012. The incidences of adverse outcomes were determined in three subgroups with PAPP-A levels < 0...
October 17, 2016: Prenatal Diagnosis
Florentine F Thurik, Marije Lamain-de Ruiter, Ahmad Javadi, Anneke Kwee, Heleen Woortmeijer, Godelieve C M L Page-Christiaens, Arie Franx, C Ellen van der Schoot, Wendy Koster
OBJECTIVE: To study associations of first trimester cell-free fetal DNA levels (in this paper referred to as cell-free placental DNA (cfpDNA) levels) and preeclampsia (PE), pregnancy-induced hypertension (PIH), gestational diabetes (GDM) and spontaneous preterm birth (sPB). METHOD: A nested case-control study was conducted in first trimester samples (gestational age (GA) 8(+0) -13(+6) weeks). A total of 226 cases and 301 controls were included. CfpDNA levels were quantified in male-bearing pregnancies using real-time DYS14-PCRs on DNA isolated from maternal serum...
October 12, 2016: Prenatal Diagnosis
H Gutiérrez-Leonard, E Martínez-Lara, A E Fierro-Macías, V M Mena-Burciaga, M D Ronquillo-Sánchez, E Floriano-Sánchez, N Cárdenas-Rodríguez
BACKGROUND: Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage. AIM: The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease...
October 11, 2016: Irish Journal of Medical Science
Maha A Al-Mohaissen, Ronald G Carere, G B John Mancini, Karin H Humphries, Beth A Whalen, Terry Lee, Frank X Scheuermeyer, Andrew P Ignaszewski
BACKGROUND: Markers of plaque destabilization and disruption may have a role in identifying non-STE- type 1 Myocardial Infarction in patients presenting with troponin elevation. We hypothesized that a plaque disruption index (PDI) derived from multiple biomarkers and measured within 24 hours from the first detectable troponin in patients with acute non-STE- type 1 MI (NSTEMI-A) will confirm the diagnosis and identify these patients with higher specificity when compared to individual markers and coronary angiography...
2016: PloS One
Mariya Angelova, Ivan Todorov, Emil Kovachev
AIM: To determine the prognostic value of the low Pregnancy-associated plasma protein A (PAPP-A) levels in the early stages of pregnancy (11-13 weeks GA) independently and in combination with a Doppler test of the uterine arteries during the second half of pregnancy (22-23 weeks GA). MATERIAL AND METHODS: The study covered the period 2010-2011 and included 106 pregnant women, aged 35-40, with a single child pregnancy. The research excluded pregnant women with anomalies of the fetus, smokers and women taking prophylactically low doses of aspirin...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
Maria Memtsa, Eric Jauniaux, Béatrice Gulbis, Netta C Nyrhinen, Davor Jurkovic
The aim of this study was to evaluate the use of biological serum markers, available routinely in most hospital clinical laboratories, in predicting successful outcomes of expectant management in women presenting with a missed miscarriage. This is a single centre observational prospective study over a 16-month period. Among the 490 women who consented to the study protocol, 83 presented with missed miscarriage during the first trimester of pregnancy and opted for expectant management. The mean gestation sac diameter and volume of the gestation sac were recorded during ultrasound examination...
September 21, 2016: Reproductive Biomedicine Online
E Merz, C Thode, B Eiben, S Wellek
AIM: Both previous versions of the German PRC algorithm developed by our group for routine first-trimester screening relied on the assumption that maternal blood sampling and fetal ultrasonography are performed at the same visit of a pregnant women. In this paper we present an extension of our method allowing also for constellations where this synchronization is abandoned through preponing blood sampling to dates before 11 weeks of gestation. METHODS: In contrast to the directly measured concentrations of the serum parameters PAPP-A and free ß-hCG, the logarithmically transformed values could be shown to admit the construction of reference bands covering the whole range from 16 to 84 mm CRL [corresponding to 63 to 98 days of gestation]...
March 2016: Ultrasound Int Open
Ying Chang, Xu Chen, Hong-Yan Cui, Xing Li, Ya-Ling Xu
The aim of the present study was to determine a predictive model for early-onset preeclampsia with fetal growth restriction (FGR) to be used at 11(+0) to 13(+6) gestational weeks, by combining the maternal serum level of pregnancy-associated plasma protein-A (PAPP-A), placental growth factor (PLGF), placental protein 13 (PP13), soluble endoglin (sEng), mean arterial pressure (MAP), and uterine artery Doppler. This was a retrospective cohort study of 4453 pregnant women. Uterine artery Doppler examination was conducted in the first trimester...
September 27, 2016: Reproductive Sciences
Serdar Balcı
OBJECTIVE: To determine predictive values of maternal serum PAPP-A (msPAPP-A) levels, uterine artery Doppler velocimetry, and fetal biometric measurements (FBMs) for poor pregnancy and poor neonatal outcomes. MATERIAL AND METHODS: This prospective cohort study was conducted on singleton pregnancies followed until delivery. Pregnancy and neonatal outcomes were evaluated with respect to the msPAPP-A level at the 11(th)-14(th) weeks, uterine artery Doppler velocimetry at the 15(th)-18(th) weeks, and FBMs at the 20(th)-24(th) and 28(th)-32(nd) weeks of pregnancy...
2016: Journal of the Turkish German Gynecological Association
Ayşe Filiz Avşar, Elçin İşlek Seçen, Gülin Feykan Yeğin Akçay, Hüseyin Levent Keskin, Emre Erdem Taş, Ahmet Ferit Dalgacı
OBJECTIVE: To investigate the relationship between the development of intrapartum fetal distress and serum pregnancy-associated plasma protein-A (PAPP-A) levels measured during first-trimester aneuploidy screening tests. MATERIAL AND METHODS: This retrospective study included 283 uncomplicated pregnancies that resulted in full-term live births via spontaneous labor or with the induction by oxytocin. Cases were divided into two groups based on whether their first-trimester PAPP-A multiple of the median (MoM) levels were ≤0...
2016: Journal of the Turkish German Gynecological Association
Koumudi Godbole, Aparna Kulkarni, Asawari Kanade, Shilpa Kulkarni, Girish Godbole, Anuradha Wakankar
OBJECTIVE: To find out whether maternal serum screening for fetal chromosomal aneuploidy predicts adverse pregnancy outcomes. METHODS: A two-year retrospective case-control study was conducted at a tertiary hospital. Pregnant women with a high-risk serum screen but with chromosomally normal fetuses (n = 189) were compared to those with low-risk screen (controls, n = 157) for adverse pregnancy outcomes. RESULTS: Women with high-risk double marker or combined screen were found to have higher prevalence of LBW [OR 2...
October 2016: Journal of Obstetrics and Gynaecology of India
C Martínez-Payo, G Villa López, L Avilleira, A Arranz, F J Vargas, M Merino, V Engels Calvo, T Pérez Medina
No abstract text is available yet for this article.
September 2016: Ultrasound in Obstetrics & Gynecology
Grigorios A Karampas, Makarios I Eleftheriades, Konstantinos C Panoulis, Myrto D Rizou, Alexander D Haliassos, Dimitra K Metallinou, George P Mastorakos, Demetrios A Rizos
OBJECTIVE: To determine the performance of maternal characteristics, Doppler and a set of biochemical markers for pre-eclampsia (PE) screening at 11+0 to 13+6 and 20+1 to 25+6 weeks' gestation. STUDY DESIGN: Prospectively enrolled women at 11+0 to 13+6 and 20+1 to 25+6 weeks. Maternal characteristics, uterine artery pulsatility index (UtA-PI), ductus venosus pulsatility index (DV-PI) and serum biomarkers including pregnancy associated plasma protein - A (PAPP-A), placental growth factor (PlGF), soluble fms-like tyrosine kinase 1 (sFlt-1), s-Flt-1/PLGF ratio, asymmetric dimethylarginine (ADMA), matrix metalloproteinase 9 (MMP-9), neutrophil gelatinase-associated lipocalin (NGAL) and MMP-9/NGAL complex were recorded...
October 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Jyotsna Verma, Divya C Thomas, Geetu Jhingan, Ratna D Puri, I C Verma
OBJECTIVE: To determine the diagnostic accuracy of preeclampsia (PE) screening test offered in early pregnancy for the prediction of the risks for early-onset (requiring delivery <32 weeks gestation) and late-onset (requiring delivery ≥32 weeks gestation) disease. METHODS: In a retrospective study of 615 women with singleton pregnancy, the risk for PE was calculated by the combined effect of multiple variables: serum placental growth factor (PLGF) and pregnancy-associated plasma protein-A (PAPP-A), maternal age, parity, ethnicity, mean arterial pressure (MAP), body mass index (BMI), uterine artery-pulsatility index, and previous history of PE or hypertension (HT)...
September 6, 2016: Hypertension in Pregnancy
Mette Faurholdt Gude, Rikke Hjortebjerg, Claus Oxvig, Anne Anker Thyø, Nils Erik Magnusson, Mette Bjerre, Steen B Pedersen, Jan Frystyk
OBJECTIVE: Adipose tissue secretes pregnancy-associated plasma protein-A (PAPP-A), which may increase local IGF-action through cleavage of IGF-binding-protein-4 (IGFBP-4). We tested whether this mechanism was operational in human visceral and subcutaneous adipose tissue (i.e. VAT and SAT). DESIGN: Explants of VAT and SAT from 26 obese subjects (hereof 17 women, BMI 39.8±1.3 kg/m2) and SAT from 8 lean, age-matched women (BMI 23.2±0.7 kg/m2) were incubated with or without GH (100 µg/l) and media harvested...
September 1, 2016: European Journal of Endocrinology
Sofia Mastrodima, Ranjit Akolekar, Guelen Yerlikaya, Thanasis Tzelepis, Kypros H Nicolaides
OBJECTIVES: To develop a model for prediction of stillbirth based on a combination of maternal characteristics and medical history with first trimester biochemical and biophysical markers and evaluate the performance of screening of this model for all stillbirths and those due to impaired placentation and unexplained causes. METHODS: This was a prospective screening study of 76,897 singleton pregnancies including 76,629 live births and 268 (0.35%) antepartum stillbirths; 157 (59%) were secondary to impaired placentation and 111 (41%) were due to other or unexplained causes...
August 26, 2016: Ultrasound in Obstetrics & Gynecology
Ranjit Akolekar, Mirian Machuca, Mariane Mendes, Vasileios Paschos, Kypros H Nicolaides
OBJECTIVES: To investigate whether measurement of maternal serum placental growth factor (PLGF) at 11-13 weeks' gestation improves the performance of screening for stillbirths that is achieved by a combination of maternal factors and first trimester biomarkers such as maternal serum pregnancy associated plasma protein-A (PAPP-A), ductus venosus pulsatility index for veins (DV-PIV) and uterine artery pulsatility index (UT-PI) PI and to evaluate the performance of screening of this model for all stillbirths and those due to impaired placentation and unexplained causes...
August 26, 2016: Ultrasound in Obstetrics & Gynecology
Marta Santorum, David Wright, Argyro Syngelaki, Natalia Karagioti, Kypros H Nicolaides
OBJECTIVE: To examine the diagnostic accuracy of a previously developed model for the first-trimester combined test in screening for trisomies 21, 18 and 13. METHODS: This was a prospective validation study of screening for trisomies 21, 18 and 13 by a combination of maternal age, fetal nuchal translucency, fetal heart rate and serum free ß-hCG and PAPP-A at 11(+0) -13(+6) weeks' gestation in 108,982 singleton pregnancies undergoing routine care in three maternity hospitals...
August 23, 2016: Ultrasound in Obstetrics & Gynecology
Joyce L Browne, Kerstin Klipstein-Grobusch, Maria P H Koster, Dhivya Ramamoorthy, Edward Antwi, Idder Belmouden, Arie Franx, Diederick E Grobbee, Peter C J I Schielen
BACKGROUND: Baseline distributions of pregnancy disorders' biomarkers PlGF and PAPP-A levels are primarily based on Western European populations of Caucasian ethnicity. Differences in PAPP-A and PlGF concentrations by ethnicity have been observed, with increased levels in Afro-Caribbean, East Asian, and South Asian women. Baseline concentrations of sub-Saharan African women have not been evaluated. OBJECTIVES: To investigate PlGF and PAPP-A in a sub-Saharan African population and assess the performance of existing reference values of PAPP-A and PlGF...
2016: PloS One
Andrea Lanes, Tianhua Huang, Ann E Sprague, Arthur Leader, Beth Potter, Mark Walker
OBJECTIVE: To study the current literature on the association between IVF treatment and maternal serum screening marker levels and nuchal translucency thickness. DESIGN: Systematic review. SETTINGS: Not applicable. PATIENT(S): Eligible studies included those with an exposed group of pregnant women that used IVF with or without intracytoplasmic sperm injection to conceive and a control group of pregnant women who conceived spontaneously...
August 13, 2016: Fertility and Sterility
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