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https://www.readbyqxmd.com/read/29904925/use-of-fluorescein-isothiocyanate-isomer-i-to-study-the-mechanism-of-intestinal-absorption-of-fucoidan-sulfate-in-vivo-and-in-vitro
#1
E Zhang, Fulong Chu, Lixu Xu, Hao Liang, Shuliang Song, Aiguo Ji
A new method to label fucoidan sulfate was established with tyramine and fluorescein isothiocyanate isomer I (FITC). The fluorescence spectrophotometry and high performance liquid chromatography verified the successful labelling of fucoidan by FITC. The results of the single-pass intestinal perfusion indicated jejunum and ileum as the main absorption sites, and there was carrier saturation. In addition, fucoidan sulfate at 1 mg/mL had no inhibitory effect on Caco-2 cell proliferation. Studies on the transmembrane transport mechanism showed that fucoidan can be absorbed because the apparent permeability coefficient of drugs (Papp ) A→B was 3...
June 14, 2018: Biopharmaceutics & Drug Disposition
https://www.readbyqxmd.com/read/29898442/a-novel-early-pregnancy-risk-prediction-model-for-gestational-diabetes-mellitus
#2
Arianne N Sweeting, Jencia Wong, Heidi Appelblom, Glynis P Ross, Heikki Kouru, Paul F Williams, Mikko Sairanen, Jon A Hyett
INTRODUCTION: Accurate early risk prediction for gestational diabetes mellitus (GDM) would target intervention and prevention in women at the highest risk. We evaluated novel biomarker predictors to develop a first-trimester risk prediction model in a large multiethnic cohort. METHODS: Maternal clinical, aneuploidy and pre-eclampsia screening markers (PAPP-A, free hCGβ, mean arterial pressure, uterine artery pulsatility index) were measured prospectively at 11-13+6 weeks' gestation in 980 women (248 with GDM; 732 controls)...
June 13, 2018: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/29896812/screening-for-pre-eclampsia-by-maternal-factors-and-biomarkers-at-11-13-weeks-gestation
#3
Min Yi Tan, Argyro Syngelaki, Liona C Poon, Daniel L Rolnik, Neil O'Gorman, Juan Luis Delgado, Ranjit Akolekar, Liountmila Konstantinidou, Maria Tsavdaridou, Slavyana Galeva, Ursula Ajdacka, Francisca S Molina, Nicola Persico, Jacques C Jani, Walter Plasencia, Elena Greco, George Papaioannou, Alan Wright, David Wright, Kypros H Nicolaides
OBJECTIVE: To examine the performance of screening for early-, preterm- and term-preeclampsia (PE) at 11-13 weeks' gestation by maternal factors and combinations of mean arterial pressure (MAP), uterine artery pulsatility index (UtA-PI), serum placental growth factor (PLGF) and serum pregnancy associated plasma protein-A (PAPP-A). METHODS: The data for this study were derived from three previously reported prospective non-intervention screening studies at 11+0 - 13+6 weeks' gestation in a combined total of 61,174 singleton pregnancies, including 1,770 (2...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29895998/first-trimester-uterine-artery-pulsatility-index-and-maternal-serum-papp-a-and-plgf-in-prediction-of-preeclampsia-in-primigravida
#4
Mostafa Abdo Ahmed Salem, Islam Mohamed Magdi Ammar
Background: Preeclampsia is a heterogeneous disorder affecting different body systems and frequently associated with morbidity and mortality. Early preeclampsia prediction will reduce this associated morbidity and mortality as it will give the chance for frequent maternal and fetal surveillance and application of prophylactic procedures. Objective: The aim of this work is to evaluate the role of mean pulsatility index (PI) of the uterine arteries and maternal serum concentrations of pregnancy-associated plasma protein A (PAPP-A) and placental growth factor (PlGF) in early preeclampsia prediction in primigravida...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29880172/elevated-papp-a-levels-in-lean-patients-with-polycystic-ovary-syndrome
#5
Merve Öztürk, Mesut Öktem, S Özlem Altinkaya, Emel Özalp Öktem, Şehri Elbeg, Ahmet Erdem, Mehmet Erdem
OBJECTIVES: This study aimed to evaluate the serum concentrations of PAPP-A (pregnancy associated placental protein-A), a biomarker which is associated with cardiovascular disease, in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: A total of 62 women with PCOS, and 68 age and body mass index (BMI) matched controls were eligible for the study. Hirsutism scores, hormonal and metabolic profile as well as PAPP-A levels were assessed in each subject...
June 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29864720/igfbp-4-and-papp-a-in-normal-physiology-and-disease
#6
REVIEW
Rikke Hjortebjerg
Insulin-like growth factor (IGF) binding protein-4 (IGFBP-4) is a modulator of the IGF system, exerting both inhibitory and stimulatory effects on IGF-induced cellular growth. IGFBP-4 is the principal substrate for the enzyme pregnancy-associated plasma protein-A (PAPP-A). Through IGF-dependent cleavage of IGFBP-4 in the vicinity of the IGF receptor, PAPP-A is able to increase IGF bioavailability and stimulate IGF-mediated growth. Recently, the stanniocalcins (STCs) were identified as novel inhibitors of PAPP-A proteolytic activity, hereby adding additional members to the seemingly endless list of proteins belonging to the IGF family...
May 30, 2018: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/29844094/papp-a-and-cancer
#7
REVIEW
Cheryl A Conover, Claus Oxvig
The zinc metalloproteinase, PAPP-A, enhances local insulin-like growth factor (IGF) action through cleavage of inhibitory IGF-binding proteins, thereby increasing IGF available for IGF receptor-mediated cell proliferation, migration and survival. In many tumors, enhanced IGF receptor signaling is associated with tumor growth, invasion and metastasis. We will first discuss PAPP-A structure and function, and post-translational inhibitors of PAPP-A expression or proteolytic activity. We will then review the evidence supporting an important role for PAPP-A in many cancers, including breast, ovarian and lung cancer, and Ewing sarcoma...
July 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29804337/-pre-eclampsia-a-new-test-for-an-old-disease
#8
REVIEW
Ran Svirsky, Noa Feldman, Orna Levinsohn-Tavor, Narine Galoyan, Ron Maymon
In the western world, pre-eclampsia, diagnosed in 3-5% of pregnant women, is a major cause of maternal and fetal morbidity and mortality. Once pre-eclampsia is diagnosed, the only effective treatment is delivery. There are known historical risk factors for the development of pre-eclampsia, however only 30% of the women who will develop pre-eclampsia are identified based on their presence. Recently, new first trimester algorithms for the prediction of pre-eclampsia were developed, based on the observation that pregnant women who develop pre-eclampsia have imbalanced placental angiogenic factors and that failure of the trophoblastic migration may change the flow in the uterine arteries...
May 2018: Harefuah
https://www.readbyqxmd.com/read/29804175/cryopreservation-of-ovarian-tissue-may-be-considered-in-young-girls-with-galactosemia
#9
Linn Salto Mamsen, Thomas W Kelsey, Erik Ernst, Kirsten Tryde Macklon, Allan Meldgaard Lund, Claus Yding Andersen
PURPOSE: The aim was to describe the first experience with fertility preservation by cryopreservation of ovarian tissue (OTC) in pre-pubertal girls with galactosemia and further to characterize ovarian follicular morphology and expression of proteins important for ovarian function. METHODS: Retrospectively, follicle density was estimated in ovarian cortical tissues from 6 pre-pubertal girls below the age of 12 years diagnosed with galactosemia and from 31 girls below the age of 18 years who had one ovary removed for fertility preservation for other reasons prior to gonadotoxic treatment...
May 26, 2018: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/29802620/pregnancy-associated-plasma-protein-a-and-mortality-in-haemodialysis
#10
Erik Nilsson, Tobias Rudholm, Peter Stenvinkel, Johan Ärnlöv
BACKGROUND: Elevated pregnancy-associated plasma protein A (PAPP-A) levels are associated with increased risk of death in ischaemic heart disease as well as in haemodialysis patients. Previous research indicates that the prognostic value of PAPP-A may be stronger in patients with concomitant diabetes mellitus or signs of inflammation. We studied the association between PAPP-A and outcomes in prevalent haemodialysis patients and hypothesized that diabetes mellitus and inflammation status act as effect modifiers...
May 26, 2018: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/29786509/-targeted-screening-for-pre-eclampsia-in-the-first-trimester-of-pregnancy-at-toulouse-university-hospital
#11
A Genoux, P Guerby, M Morin, B Perret, C Vayssière, S M Hamdi
GOALS: Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality. Early treatment by aspirin has been shown to significantly reduce PE risk before 37weeks supporting the implementation of first-trimester screening. SUBJECTS AND METHODS: A targeted screening was recently implemented at Toulouse University Hospital for women in their first pregnancy or those with personal or familial history of PE. It uses Fetal Medicine Foundation (FMF) algorithm that combines maternal characteristics, clinical, biophysical and biochemical (PAPP-A, Pregnancy Associated Plasma Protein-A, and PlGF, Placental Growth Factor) data...
May 18, 2018: Annales de Cardiologie et D'angéiologie
https://www.readbyqxmd.com/read/29781076/first-trimester-combined-screening-for-fetal-aneuploidies-enhanced-with-additional-ultrasound-markers-an-8-year-prospective-study
#12
Dragos Nemescu, Adina Bratie, Alexandra Mihaila, Dan Navolan, Adina Tanase
OBJECTIVES: To describe our screening population and audit of the performance of first-trimester screening for Down syndrome, based on a combined test, enhanced with additional ultrasound markers, over the whole period of the study. MATERIAL AND METHODS: We performed a prospective study from 2009 to 2016, which included 1358 singleton fetuses with a crown-rump length of 45-84 mm. The risk of aneuploidy was calculated using nuchal translucency, fetal heart rate (FHR), and additional markers, such as nasal bone (NB), tricuspid flow (TF) and ductus venosus (DV), combined with maternal serum free β-human chorionic gonadotropin (fβ-hCG) and pregnancy-associated plasma protein-A (PAPP-A)...
2018: Ginekologia Polska
https://www.readbyqxmd.com/read/29758559/circrna-0004904-circrna-0001855-and-papp-a-potential-novel-biomarkers-for-the-prediction-of-preeclampsia
#13
Min Jiang, Gendie E Lash, Xueqing Zhao, Yan Long, Caijiao Guo, Hongling Yang
BACKGROUND/AIMS: Circular RNAs (circRNAs) are transcribed prevalently in the genome; however, their potential roles in multiple cardiovascular diseases, particularly preeclampsia (PE), are not yet well understood. This study investigated the expression profiles of circRNAs and explored circRNA-mediated pregnancy-associated plasma protein A (PAPP-A) expression as a potential biomarker for PE before 20 weeks of pregnancy. METHODS: A nested case-control two-phase screening/validation study was performed in pregnant women before 20 weeks of gestation (before clinical diagnosis) at Guangzhou Women and Children's Medical Center from 2012 to 2015...
2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29723400/meta-regression-analysis-to-evaluate-relationships-between-maternal-blood-levels-of-placentation-biomarkers-and-low-delivery-weight
#14
REVIEW
Eita Goto
BACKGROUND: Caution is required for women at increased risk of low neonatal delivery weight. OBJECTIVES: To evaluate relationships between maternal placentation biomarkers and the odds of low delivery weight. SEARCH STRATEGY: Databases including PubMed/MEDLINE were searched up to May 2017 using keywords involving biomarker names and "low birthweight." SELECTION CRITERIA: English language studies providing true- and false-positive, and true- and false-negative results of low delivery weight classified by maternal blood levels of placentation biomarkers (in units of multiple of the mean [MoM]) were included...
May 3, 2018: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29722920/prognostic-relevance-and-performance-characteristics-of-serum-igfbp-2-and-papp-a-in-women-with-breast-cancer-a-long-term-danish-cohort-study
#15
Ulrick Espelund, Andrew G Renehan, Søren Cold, Claus Oxvig, Lee Lancashire, Zhenqiang Su, Allan Flyvbjerg, Jan Frystyk
Measurement of circulating insulin-like growth factors (IGFs), in particular IGF-binding protein (IGFBP)-2, at the time of diagnosis, is independently prognostic in many cancers, but its clinical performance against other routinely determined prognosticators has not been examined. We measured IGF-I, IGF-II, pro-IGF-II, IGF bioactivity, IGFBP-2, -3, and pregnancy-associated plasma protein A (PAPP-A), an IGFBP regulator, in baseline samples of 301 women with breast cancer treated on four protocols (Odense, Denmark: 1993-1998)...
May 3, 2018: Cancer Medicine
https://www.readbyqxmd.com/read/29712555/prognostic-value-of-the-stanniocalcin-2-papp-a-igfbp-4-axis-in-st-segment-elevation-myocardial-infarction
#16
Germán Cediel, Ferran Rueda, Claus Oxvig, Teresa Oliveras, Carlos Labata, Oriol de Diego, Marc Ferrer, M Cruz Aranda-Nevado, Judith Serra-Gregori, Julio Núñez, Cosme García, Antoni Bayes-Genis
OBJECTIVE: The aim of the present study was to evaluate the prognostic value of the Stanniocalcin-2/PAPP-A/IGFBP-4 axis in patients with ST-segment elevation myocardial infarction (STEMI). METHODS: Observational cohort study performed in 1085 consecutive STEMI patients treated with early reperfusion between February 2011 and August 2014. Stanniocalcin-2, PAPP-A, and IGFBP-4 were measured using state-of-the art immunoassays. The primary outcome was the composite endpoint of all-cause mortality and readmission due to heart failure (HF)...
April 30, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29683008/first-trimester-combined-screening-biochemistry-in-detection-of-congenital-heart-defects
#17
Julia Alanen, Teemu Korpimaki, Heikki Kouru, Mikko Sairanen, Markku Leskinen, Mika Gissler, Markku Ryynanen, Jaana Nevalainen
OBJECTIVE: To evaluate the performance of first trimester biochemical markers, pregnancy-associated plasma protein-A (PAPP-A), free beta human chorionic gonadotropin (fβ-hCG), and nuchal translucency (NT) in detection of severe congenital heart defects (CHDs). METHODS: During the study period from 1 January 2008 to 31 December 2011, biochemical markers and NT were measured in 31,144 women as part of voluntary first trimester screening program for Down's syndrome in Northern Finland...
April 22, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29674192/predictive-value-of-sflt-1-plgf-sflt-1-plgf-ratio-and-papp-a-for-late-onset-preeclampsia-and-iugr-between-32-and-37-weeks-of-pregnancy
#18
C Birdir, L Droste, L Fox, M Frank, J Fryze, A Enekwe, A Köninger, R Kimmig, B Schmidt, A Gellhaus
OBJECTIVES: The aim of this study was to investigate, whether maternal serum levels of sFlt-1, PlGF and PAPP-A at third trimester of pregnancy are associated with late-onset PE and intrauterine growth retardation (IUGR) after 34 weeks of pregnancy. METHODS: This was a prospective study measuring the maternal serum levels of soluble tyrosine kinase-1 (sFlt-1), placental growth factor (PlGF) and pregnancy-associated plasma protein-A (PAPP-A) at 32-37 weeks of pregnancy: 730 patients were enrolled and 676 had neither intrauterine growth restriction (IUGR) nor preeclampsia (PE) or pregnancy induced hypertension (PIH) throughout the pregnancy...
April 2018: Pregnancy Hypertension
https://www.readbyqxmd.com/read/29673658/first-trimesters-pregnancy-associated-plasma-protein-a-levels-value-to-predict-gestational-diabetes-mellitus-a-systematic-review-and-meta-analysis-of-the-literature
#19
REVIEW
Zahra Hadizadeh Talasaz, Ramin Sadeghi, Fariba Askari, Salmeh Dadgar, Atiyeh Vatanchi
Detecting pregnant women at risk of diabetes in first months can help them by early intervention for delaying or preventing onset of GDM. In this study, we aimed to assess the Predictive value of first trimester Pregnancy related plasma protein-A (PAPP-A) levels for detecting Gestational diabetes Mellitus (GDM). This systematic review and meta-analysis was conducted through probing in databases. PubMed, Scopus, Medline and Google scholar citations were searched to find the published papers from 1974 to 2017...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29658438/a-systematic-review-of-first-trimester-biochemical-and-molecular-predictive-tests-for-preeclampsia
#20
Fatemeh Abdi, Zohreh Aghaie, Fatemeh Sadat Rahnemaie, Zainab Alimoradi
BACKGROUND: Preeclampsia is a multisystem disorder affecting 5%-8% of pregnant women. Considering the ongoing debate over the predicting value of some commercial first trimester tests, the aim of this study was to compare the existing first trimester screening tests for preeclampsia. METHODS: In this systematic review, relevant articles published during 2000-2017 were extracted from PubMed, Science Direct, Scopus, Cochrane Library, ISI Web of Science, and ProQuest databases...
April 16, 2018: Current Hypertension Reviews
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