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https://www.readbyqxmd.com/read/27923276/association-between-maternal-circulating-25-hydroxyvitamin-d-concentration-and-placental-volume-in-the-first-trimester
#1
Çiğdem Yayla Abide, Meryem Kurek Eken, Işıl Turan, Enis Özkaya, Oya Pekin, Ateş Karateke
OBJECTIVES: We aimed to assess placental volume and placental mean gray value in vitamin D deficiency and healthy placentas in the first trimester of pregnancy using three-dimensional (3D) ultrasonography and Virtual Organ Computer-aided Analysis (VOCAL). METHODS: This prospective cross sectional study comprised 274 patients, divided into two groups according to the presence or absence of vitamin D deficiency (<20ng/ml deficient, n = 153,>20 ng/ml not deficient, n= 121) in the first trimester of pregnancy...
December 6, 2016: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/27904516/serum-pregnancy-associated-plasma-protein-a-levels-in-the-first-second-and-third-trimester-of-pregnancy-relation-to-newborn-anthropometric-parameters-and-maternal-tobacco-smoking
#2
Magdalena Chełchowska, Joanna Gajewska, Joanna Mazur, Jadwiga Ambroszkiewicz, Tomasz M Maciejewski, Jerzy Leibschang
INTRODUCTION: The purpose of this study was to evaluate the associations of the first, second and third trimester serum pregnancy-associated plasma protein A (PAPP-A) concentrations with neonatal anthropometric parameters. The effect of tobacco smoking during pregnancy on PAPP-A level was also studied. MATERIAL AND METHODS: One hundred and fifty healthy pregnant women were divided into smoking and tobacco-abstinent groups. Serum PAPP-A level was measured with the KRYPTOR rapid random-access immunoassay analyzer...
December 1, 2016: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/27887594/first-trimester-serum-placental-growth-factor-and-hyperglycosylated-human-chorionic-gonadotropin-are-associated-with-pre-eclampsia-a-case-control-study
#3
Elina Keikkala, Sini Koskinen, Piia Vuorela, Hannele Laivuori, Jarkko Romppanen, Seppo Heinonen, Ulf-Håkan Stenman
BACKGROUND: To study whether maternal serum hyperglycosylated human chorionic gonadotropin (hCG-h) improves first trimester prediction of pre-eclampsia when combined with placental growth factor (PlGF), pregnancy-associated plasma protein-A (PAPP-A) and maternal risk factors. METHODS: Gestational-age-adjusted concentrations of hCG, hCG-h, PlGF and PAPP-A were analysed in serum samples by time-resolved immunofluorometric assays at 8-13 weeks of gestation. The case-control study included 98 women who developed pre-eclampsia, 25 who developed gestational hypertension, 41 normotensive women with small-for-gestational-age (SGA) infants and 177 controls...
November 25, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27881939/can-pregnancy-associated-plasma-protein-a-be-a-marker-for-the-assessment-of-atherosclerosis-risk-in-patients-with-chronic-plaque-psoriasis
#4
Mualla Polat, Guler Bugdayci, Asli Sahin, Hatice Kaya, Tuna Sezer, Serkan Ozturk
INTRODUCTION: Psoriasis is an immune-mediated chronic inflammatory dermatosis. Several studies have shown that patients with psoriasis have a much greater risk of cardiovascular diseases than the normal population. The chronic inflammation observed in psoriasis is thought to have a role in the development of atherosclerosis and vascular endothelial injury. AIM: To examine serum pregnancy-associated plasma protein-A (PAPP-A) levels, which has been regarded as a marker of early stage atherosclerosis in patients with psoriasis that do not have concurrent conventional cardiovascular risk markers...
October 2016: Postȩpy Dermatologii i Alergologii
https://www.readbyqxmd.com/read/27881070/pregnancy-specific-%C3%AE-1-glycoproteins-combined-biomarker-roles-structure-function-relationships-and-implications-for-drug-design
#5
Nurbubu T Moldogazieva, Innokenty M Mokhosoev, Alexander A Terentiev
BACKGROUND: Pregnancy specific β1-glycoproteins (PSGs) have long been recognized as trophoblast quality and embryo viability markers. However, biological roles of PSGs remain obscure, and structure/function relationships to other feto-placental proteins as well as implications for drug design have not been reviewed. This review summarizes and discusses advances in 45-year studies of PSGs with focus on the latest achievements and the challenges for future investigations. METHODS: Literature search was performed to review the majority of recent PSG studies with emphasis on usage of high-throughput integrated proteomic profiling technologies, systems biology and bioinformatics approaches that enhance novel biomarker and drug target discovery as well as protein structure/activity analysis...
November 22, 2016: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/27866393/potentially-pathogenic-circulating-autoantibodies-to-cardiac-troponin-are-present-in-hemodialysis-patients
#6
Helen J Jefferies, Risto Tertti, Saara Wittfooth, James O Burton, Kaj Metsärinne, Kim Pettersson, Christopher W McIntyre
Introduction Repetitive dialysis-induced cardiac injury is associated with elevated troponin levels, inflammation, and longitudinal reduction in cardiac function. Pathogenic autoantibodies to cardiac troponins (cTnAAb) produce inflammatory cardiomyopathy in murine models. This study aimed to explore the possibility that analogous autoimmune processes might occur in hemodialysis (HD) patients, by initially investigating cTnAAb prevalence, and exploring potential links with HD-induced myocardial stunning. Methods In 130 prevalent HD patients from two centers (Derby, UK; Turku, Finland), cTnAAb (immunoassay) and cardiac troponins were quantified...
November 20, 2016: Hemodialysis International
https://www.readbyqxmd.com/read/27854388/prediction-of-stillbirth-from-placental-growth-factor-at-11-13-weeks
#7
R Akolekar, M Machuca, M Mendes, V Paschos, K H Nicolaides
OBJECTIVES: To investigate whether the addition of maternal serum placental growth factor (PlGF) measured at 11-13 weeks' gestation improves the performance of screening for stillbirths that is achieved by a combination of maternal factors and first-trimester biomarkers such as maternal serum pregnancy-associated plasma protein-A (PAPP-A), fetal ductus venosus pulsatility index for veins (DV-PIV) and uterine artery pulsatility index (UtA-PI) and to evaluate the performance of screening with this model for all stillbirths and those due to impaired placentation and unexplained causes...
November 2016: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/27837083/a-first-trimester-biomarker-panel-for-predicting-the-development-of-gestational-diabetes
#8
Antonio Farina, Elizabeth Eklund, Dalila Bernabini, Mariangela Paladino, Francesca Righetti, Giuseppe Monti, Geralyn Lambert-Messerlian
OBJECTIVE: Serum markers measured early in pregnancy have been associated with the later diagnosis of gestational diabetes mellitus (GDM). This study aims to explore the performance of a panel of first-trimester biochemical markers for the prediction of GDM. METHODS: A case-control study was performed that included 12 women who developed GDM and 60 controls matched for maternal and gestational age at blood collection. Levels of pregnancy-associated plasma protein A (PAPP-A), soluble endoglin, pregnancy protein 13, and adiponectin (Adipo) were measured on residual sera used in first-trimester screening for Down syndrome...
November 11, 2016: Reproductive Sciences
https://www.readbyqxmd.com/read/27835040/developing-a-new-algorithm-for-first-and-second-trimester-preeclampsia-screening-in-twin-pregnancies
#9
Ron Maymon, Alla Trahtenherts, Ran Svirsky, Yaakov Melcer, Liora Madar-Shapiro, Esther Klog, Hamutal Meiri, Howard Cuckle
OBJECTIVES: Construct a new preeclampsia predicting algorithm in twins. METHODS: Twins sampled at 10-13 and 16-20 gestational weeks and their marker values were log transformed into multiples of the gestation-specific medians (MoMs) for singletons and entered into a new logistic regression model with/without prior risk factors. RESULTS: The cohort included 9 PE (18 samples) and 96 unaffected cases (175 samples) twin pregnant women. The algorithm constructed of PlGF, PAPP-A, PP13, Doppler UTPI, and MAP with prior risk factors generated an area under the curve of 0...
November 11, 2016: Hypertension in Pregnancy
https://www.readbyqxmd.com/read/27809614/lower-placental-growth-factor-and-higher-free-%C3%AE-hcg-and-papp-a-levels-in-the-fetal-circulation-of-near-term-pregnancies-complicated-with-severe-preeclampsia
#10
Verónica Paredes, Jasson A Espinoza-Caicedo, Danny Salazar-Pousada, Gustavo S Escobar, Faustino R Pérez-López, Peter Chedraui
BACKGROUND: An imbalance between anti- and angiogenic factors during early placentation is key for the development of preeclampsia. Nevertheless, the majority of studies addressing this issue relate to maternal blood and not the fetal circulation. OBJECTIVE: To measure placental growth factor (PlGF), free beta human chorionic gonadotropin (β-hCG), and pregnancy-associated plasma protein-A (PAPP-A) levels in the fetal circulation of near-term pregnancies complicated with severe preeclampsia (n = 20), and their controls matched for parity, and maternal and gestational age...
November 4, 2016: Gynecological Endocrinology
https://www.readbyqxmd.com/read/27809366/predictive-value-of-serum-pregnancy-associated-plasma-protein-a-for-patients-with-ischemic-cerebrovascular-disease
#11
Shun Wang, Jun Jiang, Chuncheng Qu, Chengwei Wang, Zhaohui Sun
BACKGROUND: To investigate the role of pregnancy-associated plasma protein A (PAPP-A) in the outcome of ischemic cerebrovascular disease. METHODS: We analyzed the levels of PAPP-A in the transient ischemic attack (TIA) patients, ischemic stroke (IS) patients and normal control, and followed up the outcome of the patients in the following 2 years. Blood samples were drawn at admission, prior to treatment with heparins. RESULTS: The levels of PAPP-A in TIA patients, IS patients and normal control were 4...
November 3, 2016: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/27793555/a-longitudinal-analysis-of-angiotensin-ii-type-1-receptor-antibody-and-angiogenic-markers-in-pregnancy
#12
Shikha Aggarwal, Neroli Sunderland, Charlene Thornton, Bei Xu, Annemarie Hennessy, Angela Makris
BACKGROUND: Preeclampsia can be caused by shallow trophoblast invasion and results in endothelial dysfunction. Angiotensin II type 1 receptor antibodies (AT1AA) may have a role in both processes. Other angiogenic markers (placental growth factor (PlGF), soluble fms-like tyrosine kinase-1 (sFlt-1) and endoglin (sEng) alter before clinically evident preeclampsia. OBJECTIVES: The aim of this study is to assess the longitudinal changes and utility of biomarkers AT1AA and angiogenic markers in hypertensive disorders of pregnancy; gestational hypertension (GHT) and preeclampsia (PE)...
October 25, 2016: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/27793387/effect-of-pregnancy-associated-plasma-protein-a-papp-a-single-nucleotide-polymorphisms-on-the-level-and-activity-of-papp-a-and-the-hormone-profile-in-fluid-from-normal-human-small-antral-follicles
#13
Jane Alrø Bøtkjær, Tanni Borgbo, Søren Kløverpris, Pernille Rimmer Noer, Claus Oxvig, Claus Yding Andersen
OBJECTIVE: To reveal a possible relationship between two single nucleotide polymorphisms (SNPs) in PAPP-A-1224 (rs7020782) and 327 (rs12375498)-and the level and activity of PAPP-A in follicular fluid (FF) of human small antral follicles, and to analyze the intrafollicular hormone levels. DESIGN: Laboratory investigation. SETTING: University hospital. PATIENT(S): Fifty volunteer women who contributed a total of 210 samples of FF from normal small antral follicles...
December 2016: Fertility and Sterility
https://www.readbyqxmd.com/read/27750370/the-risk-of-adverse-pregnancy-outcome-among-pregnancies-with-extremely-low-maternal-papp-a
#14
Marja Kaijomaa, Veli-Matti Ulander, Esa Hämäläinen, Henrik Alfthan, Helene Markkanen, Seppo Heinonen, Vedran Stefanovic
OBJECTIVE: The aim of the study was to analyze the risk of adverse pregnancy outcome in three subgroups with extremely low maternal pregnancy-associated plasma protein-A (PAPP-A), that is, <0.3 multiples of median (MoM) at the first trimester screening. METHOD: A cohort of 961 pregnancies with PAPP-A levels < 0.3 MoM at the first trimester combined screening was followed up during the study period of January 2009 to December 2012. The incidences of adverse outcomes was determined in three subgroups with PAPP-A levels < 0...
October 17, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27734510/absolute-first-trimester-cell-free-dna-levels-and-their-associations-with-adverse-pregnancy-outcomes
#15
Florentine F Thurik, Marije Lamain-de Ruiter, Ahmad Javadi, Anneke Kwee, Heleen Woortmeijer, Godelieve C M L Page-Christiaens, Arie Franx, C Ellen van der Schoot, Wendy Koster
OBJECTIVE: To study associations of first trimester cell-free fetal DNA levels (in this paper referred to as cell-free placental DNA (cfpDNA) levels) and preeclampsia (PE), pregnancy-induced hypertension (PIH), gestational diabetes (GDM) and spontaneous preterm birth (sPB). METHOD: A nested case-control study was conducted in first trimester samples (gestational age (GA) 8(+0) -13(+6) weeks). A total of 226 cases and 301 controls were included. CfpDNA levels were quantified in male-bearing pregnancies using real-time DYS14-PCRs on DNA isolated from maternal serum...
October 12, 2016: Prenatal Diagnosis
https://www.readbyqxmd.com/read/27730332/pregnancy-associated-plasma-protein-a-papp-a-as-a-possible-biomarker-in-patients-with-coronary-artery-disease
#16
H Gutiérrez-Leonard, E Martínez-Lara, A E Fierro-Macías, V M Mena-Burciaga, M D Ronquillo-Sánchez, E Floriano-Sánchez, N Cárdenas-Rodríguez
BACKGROUND: Cardiovascular disease is the leading cause of death in the Western world, and a major cause of this disease is atherosclerosis. Research has demonstrated that pregnancy-associated plasma protein A (PAPP-A) plays a role in cardiovascular disease, as evidenced by the association between PAPP-A and severity of heart damage. AIM: The aim of this work was to investigate the correlation between PAPP-A concentrations in coronary and peripheral blood and certain clinicopathological factors and antioxidant enzyme activities in patients diagnosed with coronary artery disease...
October 11, 2016: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/27711184/a-plaque-disruption-index-identifies-patients-with-non-ste-type-1-myocardial-infarction-within-24-hours-of-troponin-positivity
#17
Maha A Al-Mohaissen, Ronald G Carere, G B John Mancini, Karin H Humphries, Beth A Whalen, Terry Lee, Frank X Scheuermeyer, Andrew P Ignaszewski
BACKGROUND: Markers of plaque destabilization and disruption may have a role in identifying non-STE- type 1 Myocardial Infarction in patients presenting with troponin elevation. We hypothesized that a plaque disruption index (PDI) derived from multiple biomarkers and measured within 24 hours from the first detectable troponin in patients with acute non-STE- type 1 MI (NSTEMI-A) will confirm the diagnosis and identify these patients with higher specificity when compared to individual markers and coronary angiography...
2016: PloS One
https://www.readbyqxmd.com/read/27703566/early-prognostic-factors-for-the-progress-of-preeclampsia-our-experience-in-the-period-2010-2011
#18
Mariya Angelova, Ivan Todorov, Emil Kovachev
AIM: To determine the prognostic value of the low Pregnancy-associated plasma protein A (PAPP-A) levels in the early stages of pregnancy (11-13 weeks GA) independently and in combination with a Doppler test of the uterine arteries during the second half of pregnancy (22-23 weeks GA). MATERIAL AND METHODS: The study covered the period 2010-2011 and included 106 pregnant women, aged 35-40, with a single child pregnancy. The research excluded pregnant women with anomalies of the fetus, smokers and women taking prophylactically low doses of aspirin...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
https://www.readbyqxmd.com/read/27692600/maternal-serum-markers-in-predicting-successful-outcome-in-expectant-management-of-missed-miscarriage
#19
Maria Memtsa, Eric Jauniaux, Béatrice Gulbis, Netta C Nyrhinen, Davor Jurkovic
The aim of this study was to evaluate the use of biological serum markers, available routinely in most hospital clinical laboratories, in predicting successful outcomes of expectant management in women presenting with a missed miscarriage. This is a single centre observational prospective study over a 16-month period. Among the 490 women who consented to the study protocol, 83 presented with missed miscarriage during the first trimester of pregnancy and opted for expectant management. The mean gestation sac diameter and volume of the gestation sac were recorded during ultrasound examination...
September 21, 2016: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/27689162/prenatal-risk-calculation-prc-3-0-an-extended-doe-based-first-trimester-screening-algorithm-allowing-for-early-blood-sampling
#20
E Merz, C Thode, B Eiben, S Wellek
AIM: Both previous versions of the German PRC algorithm developed by our group for routine first-trimester screening relied on the assumption that maternal blood sampling and fetal ultrasonography are performed at the same visit of a pregnant women. In this paper we present an extension of our method allowing also for constellations where this synchronization is abandoned through preponing blood sampling to dates before 11 weeks of gestation. METHODS: In contrast to the directly measured concentrations of the serum parameters PAPP-A and free ß-hCG, the logarithmically transformed values could be shown to admit the construction of reference bands covering the whole range from 16 to 84 mm CRL [corresponding to 63 to 98 days of gestation]...
March 2016: Ultrasound International Open
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