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https://www.readbyqxmd.com/read/29149908/exosomal-micrornas-as-potential-circulating-biomarkers-in-gastrointestinal-tract-cancers-a-systematic-review-protocol
#1
Elmira Gheytanchi, Zahra Madjd, Leila Janani, Arezoo Rasti, Roya Ghods, Fatemeh Atyabi, Mohammad Hossein Asadi Lari, Sadegh Babashah
BACKGROUND: Metastasis is the most frequent type of recurrence in gastrointestinal (GI) cancers, and there is an emerging potential for new diagnostic and therapeutic approaches, especially in the cases of metastatic GI carcinomas. The expression profiles of circulating exosomal microRNAs are of particular interest as novel non-invasive diagnostic and prognostic biomarkers for improved detection of GI cancers in body fluids, especially in the serum of patients with recurrent cancers. The aim of this study is to systematically review primary studies and identify the miRNA profiles of serum exosomes of GI cancers...
November 17, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29146100/emerging-role-of-extracellular-vesicles-as-a-senescence-associated-secretory-phenotype-insights-into-the-pathophysiology-of-lung-diseases
#2
REVIEW
Tsukasa Kadota, Yu Fujita, Yusuke Yoshioka, Jun Araya, Kazuyoshi Kuwano, Takahiro Ochiya
Aging is a major risk factor for the development of chronic lung diseases such as chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and lung cancer. A main aspect of aging is the impaired function of maintaining homeostasis in the organs and body, which is associated with cellular senescence. Cellular senescence is recognized as the state of irreversible cell cycle arrest in response to a variety of cellular stresses. Senescent cells are not simply cell cycle-arrested cells; they also affect bystander cells through the secretion of bioactive molecules, termed the senescence-associated secretory phenotype (SASP)...
November 13, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29145073/target-induced-proximity-ligation-triggers-recombinase-polymerase-amplification-and-transcription-mediated-amplification-to-detect-tumor-derived%C3%A2-exosomes-in-nasopharyngeal-carcinoma-with-high-sensitivity
#3
Wanli Liu, Jianpei Li, Yixian Wu, Shan Xing, Yanzhen Lai, Ge Zhang
Tumor-derived exosomes (TEXs) are extracellular vesicles that are continuously released into the blood by tumor cells and carry specific surface markers of the original tumor cells. Substantial evidence has implicated TEXs as attractive diagnostic markers for cancer. However, the detection of TEXs in blood at an early tumor stage is challenging due to their very low concentration. Here, we established a method called PLA-RPA-TMA assay that allows TEXs to be detected with high sensitivity and specificity. Based on two proximity ligation assay (PLA) probes that recognize a biomarker on a TEX, we generated a unique surrogate DNA signal for the specific biomarker, which was synchronously amplified twice by recombinase polymerase amplification (RPA) coupled with transcription-mediated amplification (TMA), and then the products of the RPA-TMA reaction were quantitatively detected using a gold nanoparticle-based colorimetric assay...
November 9, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29143228/effect-of-exosome-biomarkers-for-diagnosis-and-prognosis-of-breast-cancer-patients
#4
REVIEW
M Wang, S Ji, G Shao, J Zhang, K Zhao, Z Wang, A Wu
PURPOSE: Exosomes are gradually detected as an indicator for diagnosis and prognosis of breast cancer in clinic and a systematic review was conducted. METHODS: A search for clinical studies published before July 1, 2017 was performed. Methods of exosome purification and identification from all studies were extracted. For diagnosis evaluation, the comparison of exosome biomarkers expression between breast cancer patients and healthy women was obtained; for prognosis prediction, the correlation between exosome biomarkers expression and chemotherapy resistance, overall survival (OS), disease-free survival (DFS), recurrence and metastasis of breast cancer was also extracted...
November 15, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/29139297/direct-exosome-quantification-via-bivalent-cholesterol-labeled-dna-anchor-for-signal-amplification
#5
Fang He, Hui Liu, Xinggang Guo, Bin-Cheng Yin, Bang-Ce Ye
Exosomes, as an important subpopulation of extracellular vesicles (EVs), play an important role in intercellular communications in various important pathophysiological processes, especially cancer-related. However, reliable and convenient quantitative methods for their determination are still technically challenging. In this study, we developed an efficient and direct method by combining immunoaffinity and lipid membrane surface modification into a single platform for specific isolation and accurate quantification of exosomes...
November 15, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/29139296/differential-content-of-proteins-mrnas-and-mirnas-suggests-that-mdsc-and-their-exosomes-may-mediate-distinct-immune-suppressive-functions
#6
Lucia Geis-Asteggiante, Ashton T Belew, Virginia K Clements, Nathan J Edwards, Suzanne Ostrand-Rosenberg, Nagib M El-Sayed, Catherine Fenselau
Myeloid-derived suppressor cells (MDSC) are immature myeloid cells that accumulate in the circulation and the tumor microenvironment of most cancer patients. There, MDSC suppress both adaptive and innate immunity, hindering immunotherapies. The inflammatory milieu often present in cancers facilitates MDSC suppressive activity, causing aggressive tumor progression and metastasis. MDSC from tumor-bearing mice release exosomes, which carry biologically active proteins and mediate some of the immunosuppressive functions characteristic of MDSC...
November 15, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/29138862/liver-kinase%C3%A2-b1-restoration-promotes-exosome-secretion-and-motility-of-lung-cancer-cells
#7
Cheng Zhang, Xiang Xiao, Minyi Chen, Hitham Aldharee, Yanfang Chen, Weiwen Long
Liver kinase B1 (LKB1) regulates a variety of cellular functions, including cell polarity, energy metabolism and cell growth, by targeting multiple signaling pathways such as AMPK/mTOR and p53. LKB1 functions as a tumor suppressor in sporadic cancers including lung cancer. Extracellular vesicles such as exosomes secreted by cancer cells modulate the tumor microenvironment and progression by targeting both tumor cells (autocrine actions) and other types of cells associated with tumors (paracrine actions). While the roles of LKB1 in cellular signaling in general is well-studied, its specific role in exosome-mediated signaling remains to be explored...
November 9, 2017: Oncology Reports
https://www.readbyqxmd.com/read/29138559/human-mesenchymal-stem-cell-derived-iron-oxide-exosomes-allow-targeted-ablation-of-tumor-cells-via-magnetic-hyperthermia
#8
U Altanerova, M Babincova, P Babinec, K Benejova, J Jakubechova, V Altanerova, M Zduriencikova, V Repiska, C Altaner
Magnetic hyperthermia, or the heating of tissues using magnetic materials, is a promising approach for treating cancer. We found that human mesenchymal stem cells (MSCs) isolated from various tissues and MSCs expressing the yeast cytosine deaminase∷uracil phosphoribosyl transferase suicide fusion gene (yCD∷UPRT) can be labeled with Venofer, an iron oxide carbohydrate nanoparticle. Venofer labeling did not affect cell proliferation or the ability to home to tumors. All Venofer-labeled MSCs released exosomes that contained iron oxide...
2017: International Journal of Nanomedicine
https://www.readbyqxmd.com/read/29137633/bi-directional-exosome-driven-intercommunication-between-the-hepatic-niche-and-cancer-cells
#9
Nikolina Dioufa, Amanda M Clark, Bo Ma, Colin H Beckwitt, Alan Wells
BACKGROUND: Our understanding of the multiple roles exosomes play during tumor progression is still very poor and the contribution of the normal tissue derived exosomes in distant seeding and tumor outgrowth has also not been widely appreciated. METHODS: Using our all-human liver microphysiological system (MPS) platform as a model to closely recapitulate the early metastatic events, we isolated exosomes from both tumor cells and liver microenvironment. RESULTS: We observed that while priming of the hepatic niche (HepN) with MDA-231 breast cancer derived exosomes facilitated seeding of the cancer cells in the liver, subsequent tumor outgrowth was diminished; this was consistent with increased entry into dormancy...
November 14, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/29137278/comprehensive-microrna-sequencing-of-exosomes-derived-from-head-and-neck-carcinoma-cells-in-vitro-reveals-common-secretion-profiles-and-potential-utility-as-salivary-biomarkers
#10
Scott Langevin, Damaris Kuhnell, Tess Parry, Jacek Biesiada, Shouxiong Huang, Trisha Wise-Draper, Keith Casper, Xiang Zhang, Mario Medvedovic, Susan Kasper
Exosomes are nano-scale, membrane encapsulated vesicles that are released by cells into the extracellular space and function as intercellular signaling vectors through horizontal transfer of biologic molecules, including microRNA (miRNA). There is evidence that cancer-derived exosomes enable the tumor to manipulate its microenvironment, thus contributing to the capacity of the tumor for immune evasion, growth, invasion, and metastatic spread. The objective of this study was to characterize differential secretion of exosomal miRNA by head and neck squamous cell carcinoma (HNSCC) and identify a set of candidate biomarkers that could be detected in non-invasive saliva samples...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29137230/adipocyte-derived-exosomes-promote-lung-cancer-metastasis-by-increasing-mmp9-activity-via-transferring-mmp3-to-lung-cancer-cells
#11
Jiaoli Wang, Yilei Wu, Jufeng Guo, Xuefeng Fei, Lei Yu, Shenglin Ma
Obesity is involved in tumor progression. However, the corresponding mechanisms remain largely unknown. Here, we report that adipocytes increase the invasive ability of tumor cells by producing exosomes with a high level of MMP3. Compared with 3T3-L1 cells, 3T3-L1 adipocytes are enriched in MMP3 protein and can transfer MMP3 to 3LL lung cancer cells. Then, MMP3 activates MMP9 activity in 3LL cells and promotes invasion in vitro and in vivo via MMP9. Furthermore, MMP3 protein levels in lung tumor tissues from obese patients are increased compared with those of non-obese patients...
October 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/29133404/correction-for-sansone-et-al-packaging-and-transfer-of-mitochondrial-dna-via-exosomes-regulate-escape-from-dormancy-in-hormonal-therapy-resistant-breast-cancer
#12
(no author information available yet)
No abstract text is available yet for this article.
November 13, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29130611/usefulness-of-exosome-encapsulated-microrna-451a-as-a-minimally-invasive-biomarker-for-prediction-of-recurrence-and-prognosis-in-pancreatic-ductal-adenocarcinoma
#13
Kunihiko Takahasi, Hisae Iinuma, Keita Wada, Shunryo Minezaki, Sachiyo Kawamura, Masahiko Kainuma, Yutaka Ikede, Makoto Shibuya, Fumihiko Miura, Keiji Sano
BACKGROUND: MicroRNAs (miRNAs) encapsulated in the exosomes of plasma is of interest as stable and minimally invasive biomarkers for recurrence and prognosis in cancer patients. The aim of this study was to clarify the predictive and prognostic value of plasma exosomal microRNA-451a (miR-451a) in patients with pancreatic ductal adenocarcinoma (PDAC). METHODS: Microarray-based expression profiling of miRNAs derived from exosomes in the plasma of 6 PDAC patients with UICC stage II was employed to identify a biomarker to distinguish between patients with and without recurrence...
November 11, 2017: Journal of Hepato-biliary-pancreatic Sciences
https://www.readbyqxmd.com/read/29127370/exosomal-mir-126-as-a-circulating-biomarker-in-non-small-cell-lung-cancer-regulating-cancer-progression
#14
Franco Grimolizzi, Federica Monaco, Francesca Leoni, Massimo Bracci, Sara Staffolani, Cristiana Bersaglieri, Simona Gaetani, Matteo Valentino, Monica Amati, Corrado Rubini, Franca Saccucci, Jiri Neuzil, Marco Tomasetti, Lory Santarelli
Lung cancer is one of the leading causes of cancer-related deaths. It is diagnosed mostly at the locally advanced or metastatic stage. Recently, micro RNAs (miRs) and their distribution in circulation have been implicated in physiological and pathological processes. In this study, miR-126 was evaluated in serum, exosome and exosome-free serum fractions in non-small cell lung cancer (NSCLC) patients at early and advanced stages, and compared with healthy controls. Down-regulation of miR-126 was found in serum of advanced stage NSCLC patients...
November 10, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29127037/exosome-function-in-aerodigestive-mucosa
#15
REVIEW
Sarina K Mueller, Angela L Nocera, Benjamin S Bleier
Exosomes are 30-150nm membrane-bound vesicles which are secreted by virtually all cell types. Exosomes have been studied in a wide range of both normal and pathologic human tissues, most notably cancer. The role of exosomes in immune surveillance, non-invasive biomarker sampling, and their potential to act as therapeutic carriers lends particular importance to mucosal barrier derived exosomes. This review focuses specifically on current knowledge regarding exosomes derived from aerodigestive membranes. Specific topics covered include: isolation and characterization techniques, physiological function, protein expression, function as biomarkers of disease, and potential therapeutic uses...
November 7, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/29122679/extracellular-vesicles-novel-mediator-for-cell-to-cell-communications-in-liver-pathogenesis
#16
REVIEW
Pradip B Devhare, Ratna B Ray
Extracellular vesicles (EVs) are membrane derived nanometer-sized vesicles. EVs are released by normal, diseased, and transformed cells in vitro and in vivo, and carry lipids, proteins, mRNAs, non-coding RNAs, and even DNA out of cells. Transferring biological information via EVs to neighboring cells and inter-cellular communication not only maintain physiological functions, but also involve in the pathogenesis of several diseases, including cancer. The aim of this review is to discuss the emerging role of EVs in viral hepatitis, non-alcoholic or alcoholic liver disease and liver cancers...
November 10, 2017: Molecular Aspects of Medicine
https://www.readbyqxmd.com/read/29121557/a-ratiometric-electrochemical-biosensor-for-the-exosomal-micrornas-detection-based-on-bipedal-dna-walkers-propelled-by-locked-nucleic-acid-modified-toehold-mediate-strand-displacement-reaction
#17
Jing Zhang, Liang-Liang Wang, Mei-Feng Hou, Yao-Kun Xia, Wen-Hui He, An Yan, Yun-Ping Weng, Lu-Peng Zeng, Jing-Hua Chen
Sensitive and selective detection of microRNAs (miRNAs) in cancer cells derived exosomes have attracted rapidly growing interest owing to their potential in diagnostic and prognostic applications. Here, we design a ratiometric electrochemical biosensor based on bipedal DNA walkers for the attomolar detection of exosomal miR-21. In the presence of miR-21, DNA walkers are activated to walk continuously along DNA tracks, resulting in conformational changes as well as considerable increases of the signal ratio produced by target-respond and target-independent reporters...
November 1, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/29118908/mir-25-is-upregulated-before-the-occurrence-of-esophageal-squamous-cell-carcinoma
#18
Yaxu Jia, Heng Lu, Cheng Wang, Junjun Wang, Chenyu Zhang, Fangyu Wang, Chunni Zhang
MicroRNAs (miRNAs) are potential biomarkers for cancer detection including esophageal squamous cell carcinoma (ESCC); however, little is known about their expression profile and diagnostic impact in esophageal squamous cell intraepithelial neoplasia, the pathological precancerous lesion of ESCC. In this study, we examined the expression levels of eight miRNAs that were reported to be deregulated in ESCC, including miR-25, let-7a, miR-100, miR-133a, miR-223, miR-375, miR-483-5p and miR-1322, in 30 pairs of esophageal squamous cell neoplasia lesion tissues and corresponding adjacent normal tissues using quantitative real-time PCR (qRT-PCR)...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/29116068/-hydrogel-microchip-as-a-tool-for-studying-exosomes-in-human-serum
#19
V I Butvilovskaya, A A Tikhonov, E N Savvateeva, A A Ragimov, E L Salimov, S A Voloshin, D V Sidorov, M A Chernichenko, A P Polyakov, M M Filushin, M V Tsybulskaya, A Yu Rubina
Exosomes are cell-derived vesicles that are secreted by both normal and cancer cells. Over the last decade, a few studies have revealed that exosomes cross talk and/or influence major tumor-related pathways such as angiogenesis and metastasis involving many cell types within the tumor microenvironment. The protein composition of the membrane of an exosome reflects that of the membrane of the cell of origin. Because of this, tumor-derived exosomes differ from exosomes that are derived from normal cells. The detection of tumor exosomes and analysis of their molecular composition hold promise for diagnosis and prognosis of cancer...
September 2017: Molekuliarnaia Biologiia
https://www.readbyqxmd.com/read/29116061/-exosomal-surface-protein-markers-in-diagnosis-of-colorectal-cancer
#20
E N Savvateeva, A A Tikhonov, V I Butvilovskaya, M V Tsybulskaya, A Yu Rubina
Colorectal cancer (CRC) is one of the most common primary malignancies. Early stages of the disease are asymptomatic in the majority of cases, leading to late detection and high mortality. Available noninvasive diagnostic techniques are limited in sensitivity and specificity, and designing new ones is still a pressing problem. Exosomes are membrane-derived microvesicles secreted into human biological fluids and provide a novel way to assess the course of an oncology disease. The review describes the repertoire of exosomal surface biomarkers found in the blood of CRC patients and the prospects of employing multiplexed tests for exosomal markers in early noninvasive diagnosis of cancer...
September 2017: Molekuliarnaia Biologiia
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