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Exosome AND cancer

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https://www.readbyqxmd.com/read/28211508/mvp-mediated-exosomal-sorting-of-mir-193a-promotes-colon-cancer-progression
#1
Yun Teng, Yi Ren, Xin Hu, Jingyao Mu, Abhilash Samykutty, Xiaoying Zhuang, Zhongbin Deng, Anil Kumar, Lifeng Zhang, Michael L Merchant, Jun Yan, Donald M Miller, Huang-Ge Zhang
Exosomes are emerging mediators of intercellular communication; whether the release of exosomes has an effect on the exosome donor cells in addition to the recipient cells has not been investigated to any extent. Here, we examine different exosomal miRNA expression profiles in primary mouse colon tumour, liver metastasis of colon cancer and naive colon tissues. In more advanced disease, higher levels of tumour suppressor miRNAs are encapsulated in the exosomes. miR-193a interacts with major vault protein (MVP)...
February 17, 2017: Nature Communications
https://www.readbyqxmd.com/read/28202351/exosomal-formulation-of-anthocyanidins-against-multiple-cancer-types
#2
Radha Munagala, Farrukh Aqil, Jeyaprakash Jeyabalan, Ashish K Agrawal, Ashley M Mudd, Al Hassan Kyakulaga, Inder P Singh, Manicka V Vadhanam, Ramesh C Gupta
Over the last two decades, berries and berry bioactives particularly anthocyanins and their aglycones anthocyanidins (Anthos) have demonstrated excellent anti-oxidant, anti-proliferative, apoptotic and anti-inflammatory properties. However, their physicochemical and pharmacokinetic limitations such as low solubility, low permeability, and poor oral bioavailability are considered as unfavorable properties for development as drugs. Therefore there is a need to develop systems for efficient systemic delivery and robust bioavailability...
February 12, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28198398/microrna-155-controls-exosome-synthesis-and-promotes-gemcitabine-resistance-in-pancreatic-ductal-adenocarcinoma
#3
Manabu Mikamori, Daisaku Yamada, Hidetoshi Eguchi, Shinichiro Hasegawa, Tomoya Kishimoto, Yoshito Tomimaru, Tadafumi Asaoka, Takehiro Noda, Hiroshi Wada, Koichi Kawamoto, Kunihito Gotoh, Yutaka Takeda, Masahiro Tanemura, Masaki Mori, Yuichiro Doki
The cancer drug gemcitabine (GEM) is a key drug for treating pancreatic ductal adenocarcinoma (PDAC), but PDAC cells develop chemoresistance after long-term administration. Since the tolerance was immediately spread to every PDAC tissue in a patient, it is assumed that some certain efficient mechanisms underlay in the development of chemoresistance. Changes in the levels of particular microRNAs or alterations in intercellular communication play a dominant role in chemoresistance development, and recent data also suggest that exosomes play an important role in this process...
February 15, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28197629/rab27a-rab27b-and-vps36-are-downregulated-in-advanced-prostate-cancer-and-show-functional-relevance-in-prostate-cancer-cells
#4
Thomas Stefan Worst, Yannic Meyer, Maria Gottschalt, Cleo-Aron Weis, Jost von Hardenberg, Christine Frank, Annette Steidler, Maurice Stephan Michel, Philipp Erben
Paracrine and long-range signaling via extracellular vesicles, such as exosomes and microvesicles, is deemed crucial for tumorigenesis, invasion and spread of solid tumors. The ESCRT machinery (endosomal sorting complexes required for transport) and Rab-proteins act as key players in vesicular trafficking and secretion. Yet, their role in prostate cancer (PCa) is unknown. Therefore, this study aimed to elucidate the relevance of these components in PCa. In silico reanalysis of genes with known involvement in vesicular trafficking and secretion in an existing microarray dataset revealed low expression of RAB27A, RAB27B and VPS36 to be predictive for reduced BCR-free survival in patients with localized PCa (p=0...
February 10, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28197368/immunosuppressive-cd14-hla-dr-lo-neg-monocytes-are-elevated-in-pancreatic-cancer-and-primed-by-tumor-derived-exosomes
#5
Naureen Javeed, Michael P Gustafson, Shamit K Dutta, Yi Lin, William R Bamlet, Ann L Oberg, Gloria M Petersen, Suresh T Chari, Allan B Dietz, Debabrata Mukhopadhyay
Immunological strategies to treat pancreatic cancer offer new therapeutic approaches to improve patient outcomes. Understanding alterations in the immune systems of pancreatic cancer patients will likely lead to advances in immunotherapy for the disease. We profiled peripheral blood leukocytes from pancreatic cancer patients (n = 22) and age-matched controls (n = 20) using flow cytometry. Immune profiling of pancreatic cancer patients identified phenotypic changes in various immune cell populations, including a population of immunosuppressive monocytes (CD14(+)HLA-DR(lo/neg)), which were shown to be increased in these patients...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28192938/size-dependent-lipidomic-analysis-of-urinary-exosomes-from-patients-with-prostate-cancer-by-flow-field-flow-fractionation-and-nanoflow-liquid-chromatography-tandem-mass-spectrometry
#6
Joon Seon Yang, Jong Cheol Lee, Seul Kee Byeon, Koon Ho Rha, Myeong Hee Moon
Exosomes are membrane-bound extracellular vesicles involved in intercellular communication and tumor cell metastasis. In this study, flow field-flow fractionation (FlFFF) was utilized to separate urinary exosomes by size, demonstrating a significant difference in exosome sizes between healthy controls and patients with prostate cancer (PCa). Exosome fractions of different sizes were collected for microscopic analysis during an FlFFF run and evaluated with exosome marker proteins using Western blot analysis...
February 2, 2017: Analytical Chemistry
https://www.readbyqxmd.com/read/28192399/c-met-mir-130b-axis-as-novel-mechanism-and-biomarker-for-castration-resistance-state-acquisition
#7
A Cannistraci, G Federici, A Addario, A L Di Pace, L Grassi, G Muto, D Collura, M Signore, L De Salvo, S Sentinelli, G Simone, M Costantini, S Nanni, A Farsetti, V Coppola, R De Maria, D Bonci
Although a significant subset of prostate tumors remain indolent during the entire life, the advanced forms are still one of the leading cause of cancer-related death. There are not reliable markers distinguishing indolent from aggressive forms. Here we highlighted a new molecular circuitry involving microRNA and coding genes promoting cancer progression and castration resistance. Our preclinical and clinical data demonstrated that c-Met activation increases miR-130b levels, inhibits androgen receptor expression, promotes cancer spreading and resistance to hormone ablation therapy...
February 13, 2017: Oncogene
https://www.readbyqxmd.com/read/28191696/a-new-approach-in-stem-cell-research-exosomes-their-mechanism-of-action-via-cellular-pathways
#8
REVIEW
Burak Derkus, Kaan C Emregul, Emel Emregul
Exosomes are nano-sized vesicles surrounded by a lipid membrane, which tend to be secreted towards extra-cellular environments. Despite being defined as vesicles involved in excretion of molecular wastes by Rose Johnstone in the 1970's, further studies revealed them to be effective in various biological processes such as cancer development, regulation of the immune system, intercellular communication, stem cell biology and tissue/organ regeneration. Although many studies dealing with the role of exosomes in stem cell differentiation and the use of exosomes isolated from stem cells, for treatment of several diseases have been published, the involved mechanisms remain largely unknown...
February 13, 2017: Cell Biology International
https://www.readbyqxmd.com/read/28178672/comparative-analysis-of-microrna-expression-profiles-between-a549-a549-ddp-and-their-respective-exosomes
#9
Xiaobing Qin, Shaorong Yu, Xiaoyue Xu, Bo Shen, Jifeng Feng
Exosomes were reported to transport bioactive molecules and influence the biology behavior of recipient cells. In order to study the role of exosomal microRNAs in the mechanism of cisplatin resistance to lung cancer cells, we analyzed the expression profiles of microRNAs in A549, A549/DDP cells and their exosomes by microarray. The results showed that a certain proportion of microRNAs were co-expressed in the cells and exosomes. Linear regression analysis showed that the expression of microRNAs in A549 and A549/DDP cells were strongly correlated with those in their respective exosomes...
February 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28177881/a-panel-of-microrna-signature-in-serum-for-colorectal-cancer-diagnosis
#10
Mingxia Zhu, Zebo Huang, Danxia Zhu, Xin Zhou, Xia Shan, Lian-Wen Qi, Lirong Wu, Wenfang Cheng, Jun Zhu, Lan Zhang, Huo Zhang, Yan Chen, Wei Zhu, Tongshan Wang, Ping Liu
Dysregulated expression of specific microRNAs (miRNAs) in serum has been recognised as promising diagnostic biomarkers for colorectal cancer (CRC). In the initial screening phase, a total of 32 differentially expressed miRNAs were selected by quantitative reverse transcription polymerase chain reaction (qRT-PCR) based Exiqon panel with 3 CRC pool samples and 1 normal control (NC) pool. Using qRT-PCR, selected serum miRNAs were further confirmed in training (30 CRC VS. 30 NCs) and testing stages (136 CRC VS...
February 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28168600/the-role-of-pancreatic-cancer-derived-exosomes-in-cancer-progress-and-their-potential-application-as-biomarkers
#11
REVIEW
H Jin, Y Wu, X Tan
Pancreatic cancer is one of the most deadly cancers, with dismal prognosis due to its poor early detection rate and high metastatic rate. Thus, elucidation of the molecular mechanisms accounting for its metastasis and discovery of competent biomarkers is required. Exosomes are multivesicular body-derived small extracellular vesicles released by various cell types that serve as important message carriers during intercellular communication. They are also known to play critical roles during cancer-genesis, cancer-related immune reactions, and metastasis...
February 6, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28167415/a-visible-and-colorimetric-aptasensor-based-on-dna-capped-single-walled-carbon-nanotubes-for-detection-of-exosomes
#12
Yaokun Xia, Mengmeng Liu, Liangliang Wang, An Yan, Wenhui He, Mei Chen, Jianming Lan, Jiaoxing Xu, Lunhui Guan, Jinghua Chen
Recently, many studies have shown the potential use of circulating exosomes as novel biomarkers for monitoring and predicting a number of complex diseases, including cancer. However, reliable and cost-effective detection of exosomes in routine clinical settings, still remain a difficult task, mainly due to the lack of adequately easy and fast assay platforms. Therefore, we demonstrate here the development of a visible and simple method for the detection of exosomes by integrating single-walled carbon nanotubes that being excellent water solubility (s-SWCNTs) and aptamer...
January 28, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28167212/recruitment-of-rna-molecules-by-connexin-rna-binding-motifs-implication-in-rna-and-dna-transport-through-microvesicles-and-exosomes
#13
REVIEW
Marta Varela-Eirin, Adrian Varela-Vazquez, Marina Rodríguez-Candela Mateos, Anton Vila-Sanjurjo, Eduardo Fonseca, José L Mascareñas, M Eugenio Vázquez, Maria D Mayan
Connexins (Cxs) are integral membrane proteins that form high-conductance plasma membrane channels, allowing communication from cell to cell (via gap junctions) and from cells to the extracellular environment (via hemichannels). Initially described for their role in joining excitable cells (nerve and muscle), gap junctions (GJs) are found between virtually all cells in solid tissues and are essential for functional coordination by enabling the direct transfer of small signalling molecules, metabolites, ions, and electrical signals from cell to cell...
February 4, 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/28166442/exosomes-in-cancer-theranostic-diamonds-in-the-rough
#14
Marine Cordonnier, Gaëtan Chanteloup, Nicolas Isambert, Renaud Seigneuric, Pierre Fumoleau, Carmen Garrido, Jessica Gobbo
During the last 10 years, exosomes, which are small vesicles of 50-200 nm diameter of endosomal origin, have aroused a great interest in the scientific and clinical community for their roles in intercellular communication in almost all physiological and pathological processes. Most cells can potentially release these nanovesicles that share with the parent cell a similar lipid bilayer with transmembrane proteins and a panel of enclosed soluble proteins such as heat shock proteins and genetic material, thus acting as potential nanoshuttles of biomarkers...
February 6, 2017: Cell Adhesion & Migration
https://www.readbyqxmd.com/read/28166198/pancreatic-fibroblast-exosomes-regulate-survival-of-cancer-cells
#15
S Suklabaidya, P Dash, S Senapati
No abstract text is available yet for this article.
February 6, 2017: Oncogene
https://www.readbyqxmd.com/read/28165027/potential-role-of-corneal-epithelial-cell-derived-exosomes-in-corneal-wound-healing-and-neovascularization
#16
Kyu-Yeon Han, Jennifer A Tran, Jin-Hong Chang, Dimitri T Azar, James D Zieske
Specific factors from the corneal epithelium underlying the stimulation of stromal fibrosis and myofibroblast formation in corneal wound healing have not been fully elucidated. Given that exosomes are known to transfer bioactive molecules among cells and play crucial roles in wound healing, angiogenesis, and cancer, we hypothesized that corneal epithelial cell-derived exosomes may gain access to the underlying stromal fibroblasts upon disruption of the epithelial basement membrane and that they induce signaling events essential for corneal wound healing...
February 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28163101/identification-of-mirnas-as-biomarkers-for-acquired-endocrine-resistance-in-breast-cancer
#17
Penn Muluhngwi, Carolyn M Klinge
Therapies targeting estrogen receptor α (ERα) including tamoxifen, a selective estrogen receptor modulator (SERM) and aromatase inhibitors (AI), e.g., letrozole, have proven successful in reducing the death rate for breast cancer patients whose initial tumors express ERα. However, about 40% of patients develop acquired resistance to these endocrine treatments. There is a critical need to develop sensitive circulating biomarkers that accurately identify signaling pathways altered in breast cancer patients resistant to endocrine therapies...
February 2, 2017: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/28161058/endogenous-and-exogenous-mir-520c-3p-modulates-cd44-mediated-extravillous-trophoblast-invasion
#18
Hironori Takahashi, Akihide Ohkuchi, Tomoyuki Kuwata, Rie Usui, Yosuke Baba, Hirotada Suzuki, Tha Thu Chaw Kyi, Shigeki Matsubara, Shigeru Saito, Toshihiro Takizawa
INTRODUCTION: Adequate extravillous trophoblast (EVT) invasion is essential for successful placentation. Although miR-520c-3p plays an important role in CD44-mediated invasion in cancer cells, there is little information on whether miR-520c-3p is involved in the regulatory mechanisms of CD44-mediated EVT invasion. METHODS: We screened first trimester trophoblast cells and trophoblast cell lines for expression of miR-520c-3p using real-time polymerase chain reaction...
February 2017: Placenta
https://www.readbyqxmd.com/read/28160560/exosome-secretome-and-mediated-signaling-in-breast-cancer-patients-with-nontuberculous-mycobacterial-disease
#19
Julie V Philley, Anbarasu Kannan, David E Griffith, Megan S Devine, Jeana L Benwill, Richard J Wallace Jr, Barbara A Brown-Elliott, Foram Thakkar, Varsha Taskar, James G Fox, Ammar Alqaid, Hernaina Bains, Sudeep Gupta, Santanu Dasgupta
Bronchiectasis Nontuberculous mycobacterium (NTMnb) infection is an emerging health problem in breast cancer (BCa) patients. We measured sera exosome proteome in BCa-NTMnb subjects and controls by Mass Spectroscopy. Extracellular matrix protein 1 (ECM1) was detected exclusively in the circulating exosomes of 82% of the BCa-NTMnb cases. Co-culture of ECM1+ exosomes with normal human mammary epithelial cells induced epithelial to mesenchymal transition accompanied by increased Vimentin/CDH1 expression ratio and Glutamate production...
February 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28160157/a-comparison-of-serum-mirnas-influencing-metastatic-growth-of-emt6-vs-4thm-tumor-cells-in-wild-type-and-cd200r1ko-mice
#20
Reginald M Gorczynski, Fang Zhu, Zhiqi Chen, Ohla Kos, Ismat Khatri
PURPOSE: We investigated whether miRNAs in exosomes from EMT6 or 4THM tumor-bearing mice played a role in regulating inflammatory cytokine expression and/or metastasis in WT mice injected with EMT6 and/or 4THM tumor cells. METHODS: EMT6 tumors in BALB/c CD200R1KO mice resolve following surgical resection of localized tumor and immunization with irradiated EMT6 cells along with CpG as adjuvant. Wild-type (WT) animals treated in the same fashion develop pulmonary and liver metastases within 20 days of surgery...
February 3, 2017: Breast Cancer Research and Treatment
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