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https://www.readbyqxmd.com/read/29656364/characteristic-appearances-of-fundus-autofluorescence-in-treatment-naive-and-active-polypoidal-choroidal-vasculopathy-a-retrospective-study-of-170-patients
#1
Xinyu Zhao, Song Xia, Youxin Chen
PURPOSE: To investigate the characteristic appearances of fundus autofluorescence (FAF) in patients with treatment-naive and active polypoidal choroidal vasculopathy (PCV). METHOD: Cases with the diagnosis of treatment-naive and active PCV from November 2012 to May 2017 at Peking Union Medical College Hospital were retrospectively reviewed. All patients underwent comprehensive ophthalmologic examination. Autofluorescence (AF) findings were described at the retinal sites of the corresponding lesions identified and diagnosed using indocyanine green angiography and spectral-domain optical coherence tomography...
April 14, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29655846/telocyte-like-cells-containing-weibel-palade-bodies-in-rat-lamina-fusca
#2
C E Petrea, M C Rusu, V S Mănoiu, A D Vrapciu
Telocytes (TCs) are cells with long, thin and moniliform processes called telopodes. These cells have been found in numerous tissues, including the eye choroid and sclera. Lamina fusca (LF), an anatomical structure located at the sclera-choroid junction, has outer fibroblastic lamellae containing cells with long telopodes. The purpose of this study was to evaluate, via transmission electron microscopy, the LF for the presence of endothelial-specific ultrastructural features, such as Weibel-Palade bodies (WPBs), in the residing TCs...
April 12, 2018: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/29655645/proton-beam-irradiation-a-safe-procedure-in-post-equatorial-extraocular-extension-from-uveal-melanoma
#3
Ira Seibel, Aline I Riechardt, Katharina Erb-Eigner, Alexander Böker, Dino Cordini, Jens Heufelder, Antonia M Joussen
PURPOSE: This study was performed to show long-term outcomes concerning metastasis rates and local recurrence rates after primary proton beam therapy in uveal melanoma with posterior extraocular extension (EOE) with the main focus on optic nerve invasion. DESIGN: Retrospective case series METHODS: All patients treated with primary proton beam therapy for choroidal or ciliary body melanoma with posterior EOE between July 1998 and August 2010 were included. EOE was either detected upon sonography at primary examination or during the surgical application of tantalum clips onto the sclera...
April 12, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29652691/visual-acuity-in-pseudoxanthoma-elasticum
#4
Sara Risseeuw, Jeannette Ossewaarde-van Norel, Caroline C W Klaver, Johanna M Colijn, Saskia M Imhof, Redmer van Leeuwen
PURPOSE: To assess the age-specific proportion of visual impairment in patients with pseudoxanthoma elasticum (PXE) and to compare this with foveal abnormality and similar data of late age-related macular degeneration patients. METHODS: Cross-sectional data of 195 patients with PXE were reviewed, including best-corrected visual acuity and imaging. The World Health Organisation criteria were used to categorize bilateral visual impairment. These results were compared with similar data of 131 patients with late age-related macular degeneration from the Rotterdam study...
April 12, 2018: Retina
https://www.readbyqxmd.com/read/29652440/long-term-visual-outcomes-for-treatment-of-submacular-hemorrhage-secondary-to-polypoidal-choroidal-vasculopathy
#5
Hyun Goo Kang, Hyunseung Kang, Suk Ho Byeon, Sung Soo Kim, Hyoung Jun Koh, Sung Chul Lee, Min Kim
IMPORTANCE: There is no consensus on the optimal management of submacular hemorrhage (SMH) secondary to polypoidal choroidal vasculopathy (PCV). BACKGROUND: To compare the long-term outcome of 3 treatment strategies for PCV with SMH. DESIGN: Retrospective case series at 2 tertiary hospitals. SAMPLES: A total of 48 consecutive eyes treated between July 2006 and March 2016. METHODS: Patients were grouped according to the treatment received: 22 eyes with intravitreal bevacizumab (IVB), 14 with a combination of IVB and pneumatic displacement (PD), and 12 with IVB and vitrectomy (TPPV)...
April 13, 2018: Clinical & Experimental Ophthalmology
https://www.readbyqxmd.com/read/29651354/evolution-of-choroidal-neovascularization-due-to-presumed-ocular-histoplasmosis-syndrome-on-multimodal-imaging-including-optical-coherence-tomography-angiography
#6
T Y Alvin Liu, Alice Yang Zhang, Adam Wenick
A 37-year-old Caucasian woman presented with acute decrease in central vision in her right eye and was found to have subfoveal choroidal neovascularization (CNV) due to presumed ocular histoplasmosis syndrome (POHS). Her visual acuity improved from 20/70 to 20/20 at her 6-month follow-up, after 3 consecutive monthly intravitreal bevacizumab injections were initiated at her first visit. Although no CNV activity was seen on fluorescein angiography (FA) or spectral-domain optical coherence tomography (SD-OCT) at her 2-month, 4-month, and 6-month follow-up visits, persistent flow in the CNV lesion was detected on optical coherence tomography angiography (OCTA)...
2018: Case Reports in Ophthalmological Medicine
https://www.readbyqxmd.com/read/29651346/choriocapillaris-loss-in-advanced-age-related-macular-degeneration
#7
REVIEW
Carlos A Moreira-Neto, Eric M Moult, James G Fujimoto, Nadia K Waheed, Daniela Ferrara
The purpose of this review is to summarize the current knowledge on choriocapillaris loss in advanced age macular degeneration (AMD). Several histopathological studies in animal models and human eyes had showed that the choriocapillaris density decreases with age. However, the role of choriocapillaris loss is still unclear in AMD and its advanced forms, either choroidal neovascularization (CNV) or geographic atrophy (GA). Some authors have hypothesized that choriocapillaris loss might precede overt retinal pigment epithelium atrophy...
2018: Journal of Ophthalmology
https://www.readbyqxmd.com/read/29650401/opthalmological-sequelae-due-to-paintball-injuries-case-studies
#8
A C Peñaranda, A Montoya, A P Arciniegas, C López-de-Mesa
OBJECTIVE: Describe the ophthalmological sequelae of patients diagnosed with blunt eye injury by paintball. MATERIAL AND METHODS: There were a total 14 cases with a diagnosis of blunt trauma by paintball were treated at the ophthalmology emergency department of the Barraquer Clinic in Bogotá, Colombia. All patients underwent a complete ophthalmological examination with their respective controls according to their outcome. RESULTS: The frequency of eye trauma by paintball was 3...
April 9, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29649987/multimodal-imaging-of-foveoschisis-and-macular-pseudohole-associated-with-gyrate-atrophy-a-family-report
#9
Imène Zhioua Braham, Imen Ammous, Rim Maalej, Majdi Boukari, Ilhem Mili Boussen, Khalil Errais, Raja Zhioua
BACKGROUND: To report the results of multimodal imaging of a biochemically confirmed case of a family with gyrate atrophy (GA) associated with foveoschisis and macular pseudohole. CASE PRESENTATION: Two sisters presented to us with progressive bilateral decreased vision. The 26-year old sister had a best corrected visual acuity (BCVA) of 20/32 in the right eye (RE) and 20/100 in the left eye (LE). Dilated fundus examination revealed multiple bilateral chorioretinal atrophy areas in the midperipheral and peripheral retina...
April 12, 2018: BMC Ophthalmology
https://www.readbyqxmd.com/read/29643788/polypoidal-choroidal-vasculopathy-associated-with-optic-disc-coloboma
#10
Yumiko Nakano, Akiko Miki, Shigeru Honda, Makoto Nakamura
Purpose: To report a case of polypoidal choroidal vasculopathy associated with optic disc coloboma. Methods: Case report. Results: A 50-year-old woman presented with optic disc coloboma and retinochoroidal coloboma associated with subretinal hemorrhage and serous retinal detachment (SRD) in her left eye. Optical coherence tomography (OCT) confirmed SRD at the macula and showed a sharply elevated retinal epithelial detachment at the choroidal excavation...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29643777/a-case-of-retinal-detachment-with-unique-optical-coherence-tomography-findings-after-gamma-knife%C3%A2-radiosurgery-treatment-for-choroidal-melanoma
#11
Daisaku Kimura, Teruyo Kida, Takaki Sato, Masanori Fukumoto, Ryohsuke Kohmoto, Shota Kojima, Hiroshi Mizuno, Hitoshi Sakaguchi, Jun Sugasawa, Tsunehiko Ikeda
Purpose: To report a case of retinal detachment with unique optical coherence tomography (OCT) findings after Gamma Knife® (GK; Elekta Instrument AB, Stockholm, Sweden) treatment for choroidal melanoma (CM). Case Report: A 48-year-old woman underwent GK therapy for CM in her right eye from the macula to the temporal side. While the tumor subsequently shrank, the patient developed radiation retinopathy, which was treated with laser photocoagulation. The tumor lesions later subsided; however, her visual acuity (VA) decreased 8 years after the initial treatment...
January 2018: Case Reports in Ophthalmology
https://www.readbyqxmd.com/read/29628756/combination-of-ranibizumab-and-indomethacin-for-neovascular-age-related-macular-degeneration-randomized-controlled-trial
#12
Andrea Russo, Nicolò Scaroni, Elena Gambicorti, Raffaele Turano, Francesco Morescalchi, Ciro Costagliola, Francesco Semeraro
Purpose: The aim of this study was to evaluate whether indomethacin eye drops and intravitreal ranibizumab (IVR) injections would provide additional benefit over ranibizumab alone in the treatment of choroidal neovascularization (CNV). Participants and methods: This was a randomized, prospective pilot study of eyes with new-onset CNV. Fifty-eight patients were randomized 1:1 into a ranibizumab monotherapy (RM) group and a ranibizumab plus indomethacin (RI) group...
2018: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29627530/an-enriched-environment-restores-hepatitis-b-vaccination-mediated-impairments-in-synaptic-function-through-ifn-%C3%AE-arginase1-signaling
#13
Fangfang Qi, Zejie Zuo, Saisai Hu, Yucen Xia, Dan Song, Jiechen Kong, Yang Yang, Yingying Wu, Xiao Wang, Junhua Yang, Dandan Hu, Qunfang Yuan, Juntao Zou, Kaihua Guo, Jie Xu, Zhibin Yao
Activation of the neonatal immune system may contribute to deficits in neuronal plasticity. We have reported that neonatal vaccination with a hepatitis B vaccine (HBV) transiently impairs mood status and spatial memory involving a systemic T helper (Th) 2 bias and M1 microglial activation. Here, an EE induced microglial anti-inflammatory M2 polarization, as evidenced by selectively enhanced expression of the Arginase1 gene (Arg-1) in the hippocampus. Interestingly, knock-down of the Arg-1 gene prevented the effects of EE on restoring the dendritic spine density...
April 5, 2018: Brain, Behavior, and Immunity
https://www.readbyqxmd.com/read/29627289/mechanisms-of-neuropsychiatric-lupus-the-relative-roles-of-the-blood-cerebrospinal-fluid-barrier-versus-blood-brain-barrier
#14
Sivan Gelb, Ariel D Stock, Shira Anzi, Chaim Putterman, Ayal Ben-Zvi
The pathogenesis of neuropsychiatric lupus (NPSLE) is believed to include the entry of circulating neuropathic antibodies to the brain via a pathologically permeable blood-brain barrier (BBB). Nevertheless, direct evidence of BBB pathology or mechanisms underlying BBB dysfunction is missing. Here, we examined BBB integrity in an established NPSLE mouse model (MRL/faslpr/lpr ). Surprisingly, challenging the barrier with various exogenous tracers demonstrated insignificant changes in BBB permeability. Furthermore, electron microscopy showed no ultrastructure changes supporting hyper-permeability...
April 4, 2018: Journal of Autoimmunity
https://www.readbyqxmd.com/read/29627228/establishment-of-an-abnormal-vascular-patterning-model-in-the-mouse-retina
#15
Akane Morita, Shohei Sawada, Asami Mori, Shiho Arima, Kenji Sakamoto, Tohru Nagamitsu, Tsutomu Nakahara
Abnormalities in retinal blood vessels and neuronal function persist in eyes undergoing retinopathy of prematurity. In this study, we examined morphological and functional changes in retinal blood vessels and neurons in mice that had undergone short-term interruption of retinal vascular development through inhibition of vascular endothelial growth factor (VEGF) signaling. In mice treated with the VEGF receptor tyrosine kinase inhibitor KRN633 on postnatal day (P) 0 and 1, the vascular density in the retinal surface increased by P12, but development of deep retinal vascular plexus and choroidal vasculature was delayed until P14...
March 14, 2018: Journal of Pharmacological Sciences
https://www.readbyqxmd.com/read/29625839/choroidal-and-sub-retinal-pigment-epithelium-caverns-multimodal-imaging-and-correspondence-with-friedman-lipid-globules
#16
Rosa Dolz-Marco, Jay P Glover, Orly Gal-Or, Katie M Litts, Jeffrey D Messinger, Yuhua Zhang, Mariano Cozzi, Marco Pellegrini, K Bailey Freund, Giovanni Staurenghi, Christine A Curcio
PURPOSE: To survey Friedman lipid globules by high-resolution histologic examination and to compare with multimodal imaging of hyporeflective caverns in eyes with geographic atrophy (GA) secondary to age-related macular (AMD) and other retinal diseases. DESIGN: Histologic survey of donor eyes with and without AMD. Clinical case series with multimodal imaging analysis. PARTICIPANTS: Donor eyes (n = 139; 26 with early AMD, 13 with GA, 40 with nAMD, 52 with a healthy macula, and 8 with other or unknown characteristics) and 41 eyes of 28 participants with GA (n = 16), nAMD (n = 8), Stargardt disease (n = 4), cone dystrophy (n = 2), pachychoroid spectrum (n = 6), choroidal hemangioma (n = 1), and healthy eyes (n = 4)...
April 3, 2018: Ophthalmology
https://www.readbyqxmd.com/read/29625482/distribution-pattern-of-choroidal-thickness-at-the-posterior-pole-in-chinese-children-with-myopia
#17
Junjie Deng, Xiaoli Li, Jiali Jin, Bo Zhang, Jianfeng Zhu, Haidong Zou, Xun Xu, Jingbo Xie, Ling Wang, Shaopin Zhu, Xiangui He
Purpose: To determine the relationship between choroidal thickness (ChT) at the posterior pole and refractive error and to explore the difference between the macular and peripapillary regions in children with myopia. Methods: A total of 340 healthy Chinese children underwent a series of comprehensive ocular examinations including cycloplegic refraction. Swept-source optical coherence tomography was used to measure the ChT in the macular and peripapillary regions...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625478/genetic-risk-factors-for-radiation-vasculopathy
#18
Thanos D Papakostas, Margaux A Morrison, Anne Marie Lane, Caroline Awh, Margaret M DeAngelis, Evangelos S Gragoudas, Ivana K Kim
Purpose: The purpose of this study was to perform a genome-wide scan for polymorphisms associated with risk of vision loss from radiation complications in patients treated with proton beam irradiation for choroidal melanoma. Methods: We identified a cohort of 126 patients at high risk of radiation complications due to tumor location within 2 disc diameters of the optic nerve and/or fovea who provided a blood sample to the Massachusetts Eye and Ear Uveal Melanoma Repository...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625464/safety-studies-for-a-44-channel-suprachoroidal-retinal-prosthesis-a-chronic-passive-study
#19
Carla J Abbott, David A X Nayagam, Chi D Luu, Stephanie B Epp, Richard A Williams, Cesar M Salinas-LaRosa, Joel Villalobos, Ceara McGowan, Mohit N Shivdasani, Owen Burns, Jason Leavens, Jonathan Yeoh, Alice A Brandli, Patrick C Thien, Jenny Zhou, Helen Feng, Chris E Williams, Robert K Shepherd, Penelope J Allen
Purpose: Following successful clinical outcomes of the prototype suprachoroidal retinal prosthesis, Bionic Vision Australia has developed an upgraded 44-channel suprachoroidal retinal prosthesis to provide a wider field of view and more phosphenes. The aim was to evaluate the preclinical passive safety characteristics of the upgraded electrode array. Methods: Ten normal-sighted felines were unilaterally implanted with an array containing platinum electrodes (44 stimulating and 2 returns) on a silicone carrier near the area centralis...
March 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29625461/allogeneic-ipsc-derived-rpe-cell-graft-failure-following-transplantation-into-the-subretinal-space-in-nonhuman-primates
#20
Trevor J McGill, Jonathan Stoddard, Lauren M Renner, Ilhem Messaoudi, Kapil Bharti, Shoukhrat Mitalipov, Andreas Lauer, David J Wilson, Martha Neuringer
Purpose: To characterize the intraocular immune response following transplantation of iPS-derived allogeneic RPE cells into the subretinal space of non-immune-suppressed rhesus macaques. Methods: GFP-labeled allogeneic iPS-derived RPE cells were transplanted into the subretinal space of one eye (n = 6), and into the contralateral eye 1 day to 4 weeks later, using a two-stage transretinal and transscleral approach. Retinas were examined pre- and post-surgery by color fundus photography, fundus autofluorescence, and optical coherence tomography (OCT) imaging...
March 1, 2018: Investigative Ophthalmology & Visual Science
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