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Choroiditis

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https://www.readbyqxmd.com/read/29045946/subfoveal-choroidal-and-macular-thickness-changes-after-phacoemulsification-using-enhanced-depth-imaging-optical-coherence-tomography
#1
Huizhong Jiang, Zhen Li, Ran Sun, Dachuan Liu, Ningpu Liu
PURPOSE: To assess changes in the thickness of the subfoveal retina and choroid after phacoemulsification using enhanced depth imaging optical coherence tomography (EDI-OCT). METHODS: A prospective study was conducted on 100 patients. The subfoveal choroidal thickness (SFCT) was measured at 7 points and the retinal thickness was measured at 5 points (before surgery, and 1 day, 1 week, 1 month, and 3 months after surgery). RESULTS: The foveal choroidal thickness showed a thickening trend (but p > 0...
October 19, 2017: Ophthalmic Research
https://www.readbyqxmd.com/read/29044669/the-advantages-of-intermediate-tier-inter-optometric-referral-of-low-risk-pigmented-lesions
#2
Angelica Ly, Lisa Nivison-Smith, Michael Hennessy, Michael Kalloniatis
PURPOSE: Pigmented ocular lesions are commonly encountered by eye-care professionals, and range from benign to sight or life-threatening. After identifying a lesion, the primary care professional must establish the likely diagnosis and decide either to reassure, to monitor or to refer. The increasing use of ocular imaging technologies has contributed to an increase in the detection rate of pigmented lesions and a higher number of referrals, which may challenge existing pathways of health-care delivery...
November 2017: Ophthalmic & Physiological Optics: the Journal of the British College of Ophthalmic Opticians (Optometrists)
https://www.readbyqxmd.com/read/29044086/optical-coherence-tomography-angiography-of-circumscribed-choroidal-hemangioma-treated-with-photodynamic-therapy
#3
Giuseppe Lo Giudice, Alessandro Galan
We describe features of a circumscribed choroidal hemangioma (CCH) treated with photodynamic therapy (PDT) by means of optical coherence tomography angiography (OCT-A). A 40-year-old man had a complaint of decreasing visual acuity in his left eye for 10 days. A diagnosis of CCH was confirmed by fundus examination, fluorescein angiography, and indocyanine green angiography. An OCT-A study of choroidal lesion before and after PDT was carried out. Segmented en face OCT-A of CCH showed multiple irregular connected vascular channels with hyperflow and a capillary-like lesion...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044080/amalric-sign-an-augur-of-ophthalmic-artery-occlusion
#4
Prathibha Hande, Babi Sinha, Shivani Nayak, Srilakshmi Srinivasan, Jyothi Shetty
A 75-year-old man presented to us with sudden onset of profound vision loss in his right eye and was identified as suffering from an ophthalmic artery occlusion. Apart from the retinal whitening and box-carring of the retinal arteries, there were characteristic triangular patches of retinal whitening in the midperipheral temporal fundus indicating a previous lateral posterior choroidal artery occlusion. The patient was a chronic smoker and had dyslipidemia. The carotid Doppler study showed complete occlusion of the internal carotid artery...
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29044079/ultrasonographic-evaluation-of-transition-from-normal-to-ectatic-area-a-comparison-between-myopic-staphylomata-and-coloboma
#5
Anubha Rathi, Brijesh Takkar, Pradeep Venkatesh, Nripen Gaur, Atul Kumar
Choroidal coloboma and posterior staphyloma are two clinically distinct entities, with choroidal excavation being a unifying feature. They are associated with early onset cataract which can make ophthalmoscopy difficult. This report studies the transition between the normal and ectatic area in these cases with ultrasound. We evaluate "posterior hump" as a sign of differentiation between these two conditions.
October 2017: Indian Journal of Ophthalmology
https://www.readbyqxmd.com/read/29043448/-retinoblastoma-and-retinocytoma-retinoma
#6
REVIEW
K A Metz, D Westerwick, F Driever, K W Schmid, C H D Le Guin
Retinoblastomas are extremely rare withabout half of the cases being hereditary eye neoplasms in young children. They show highly proliferative, CRX-positive undifferentiated tumour cells (occasionally forming rosettes). Staging is performed according to the pTNM classification and the International Retinoblastoma Staging System (IRSS). The diagnostic basis for systemic administration of chemotherapy and/or radiation is postlaminar optic nerve invasion, massive choroidal tumour infiltration, scleral invasion or even extraocular invasion...
October 17, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29042922/endoscopy-in-the-treatment-of-slit-ventricle-syndrome
#7
Jiaping Zheng, Guoqiang Chen, Qing Xiao, Yiyang Huang, Yupeng Guo
The present study aimed to investigate the efficacy of endoscopy in the treatment of post-shunt placement for slit ventricle syndrome (SVS). Endoscopic surgery was performed on 18 patients with SVS between October 2004 and December 2012. Sex, age, causes of the hydrocephalus, ventricular size and imaging data were collected and analyzed. All patients were divided into two groups according to ventricular size and underwent endoscopic surgeries, including endoscopic third ventriculostomy (ETV), endoscopic aqueductoplasty and cystocisternostomy...
October 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29040677/navigation-linked-heads-up-display-in-intracranial-surgery-early-experience
#8
Justin R Mascitelli, Leslie Schlachter, Alexander G Chartrain, Holly Oemke, Jeffrey Gilligan, Anthony B Costa, Raj K Shrivastava, Joshua B Bederson
BACKGROUND: The use of intraoperative navigation during microscope cases can be limited when attention needs to be divided between the operative field and the navigation screens. Heads-up display (HUD), also referred to as augmented reality, permits visualization of navigation information during surgery workflow. OBJECTIVE: To detail our initial experience with HUD. METHODS: We retrospectively reviewed patients who underwent HUD-assisted surgery from April 2016 through April 2017...
October 10, 2017: Operative Neurosurgery (Hagerstown, Md.)
https://www.readbyqxmd.com/read/29040008/analysis-of-the-clinical-profile-and-management-of-inflammatory-choriodal-neovascular-membranes-in-uveitic-eyes-a-study-from-a-tertiary-referral-center
#9
Sudha Ganesh, Arshee Ahmed, Jyotirmay Biswas
PURPOSE: To analyze clinical profile and management of inflammatory choroidal neovascularization (CNV) seen at a referral uveitis clinic. METHODS: Records of patients with uveitis and inflammatory CNV from January 1989 to April 2012 were retrieved and the data was analyzed. RESULTS: Forty-nine eyes of 43 patients were included. Mean age at presentation was 35.81 years. Eighteen eyes (36.7%) had infective etiology and 31 eyes (63.2%) had non-infective etiology...
October 17, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/29039988/the-intraoperative-use-of-polydioxanone-foil-to-reduce-the-risk-of-sino-orbital-fistula-formation-in-orbital-exenteration
#10
Aws Al-Hity, Maria Elena Gregory, Ewan G Kemp
BACKGROUND: Orbital exenteration is a radical surgical procedure resulting in deformity. It involves removal of the globe, optic nerve, extra-ocular muscles, orbital fat, lacrimal gland, and peri-osteum. Sino-orbital fistula (SOF) formation is a common documented post-operative complication, usually connecting the orbit and the ethmoid sinus. SOFs can cause leaks of serous fluid, and act as an entry site for pathogens into the orbit leading to socket infection and breakdown. METHODS: This retrospective study analyzed exenterations performed over a 22-year period (1993-2015) at the National Ocular Oncology Service Centre for Scotland...
October 17, 2017: Orbit
https://www.readbyqxmd.com/read/29038978/panuveitis-like-reaction-following-encircling-laser-retinopexy-cerclage-in-a-21-year-old-male
#11
David Francis Fullon Chan, Milagros Herrera-Arroyo, Darby E Santiago, Teresita R Castillo, Ma Florentina Q Fajardo-Gomez
BACKGROUND: Severe vision-impairing ocular inflammation is rarely reported following extensive laser. Previous cases have involved retinal photocoagulation for diabetic retinopathy resolving over days. This report documents a rare instance of this where encircling retinopexy/cerclage was done as fellow eye retinal detachment prophylaxis in a patient with no overt comorbidities. RESULTS: A panuveitis-like reaction with severe, near-total visual impairment was documented 1 day following single-sitting encircling laser retinopexy/cerclage done as fellow eye prophylaxis for a 21-year-old male presenting with total retinal detachment in the other eye...
October 16, 2017: Journal of Ophthalmic Inflammation and Infection
https://www.readbyqxmd.com/read/29038913/-ocular-melanomas-an-update
#12
REVIEW
H Kalirai, P L Müller, D Jaehne, S E Coupland
Melanoma is the most common type of primary cancer to affect the adult eye. Approximately 95% of ocular melanomas are intraocular and arise from the uvea (i. e. iris, ciliary body, and choroid), while the remaining 5% are located in the conjunctiva. Although both uveal and conjunctival melanomas are thought to derive from malignantly transformed melanocytes, uveal melanoma is clinically and biologically distinct from conjunctival melanoma, and indeed from its more common cutaneous counterpart. Intense efforts have been recently made to understand the molecular biology involved in the development of ocular melanomas, and in their progression...
October 16, 2017: Der Pathologe
https://www.readbyqxmd.com/read/29038011/macular-fluid-reduces-reproducibility-of-choroidal-thickness-measurements-on-enhanced-depth-optical-coherence-tomography
#13
Sophia S Wong, Vivian S Vuong, David Cunefare, Sina Farsiu, Ala Moshiri, Glenn Yiu
PURPOSE: To determine if different types of retinal fluid in the central macula affect the reproducibility of choroidal thickness (CT) measurements on enhanced depth imaging optical coherence tomography (EDI-OCT) DESIGN: retrospective, reliability analysis METHODS: EDI-OCT images were obtained and the choroidal-scleral junction was analyzed through semi-automated segmentation. CT was measured at the fovea and averaged across the central 3 mm horizontal segment. Demographic data, central macular thickness and type of fluid present were recorded...
October 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29034158/malignant-choroidal-melanoma-with-suspected-vitreous-seeding-a-case-report
#14
Wen-Hsin Cheng, Cheng-Hsien Chang, Hsien-Chung Lin, Ya-Chi Chen, Chun-Chieh Wu
Retinal perforation with vitreous seeding is an uncommon condition of treatment-naïve choroidal malignant melanoma. We reported a 52-year-old male who had a pigmented tumor protruding from choroid of his right eye. He had only black shadow sensation for 4 months then a rapid deterioration of vision. Fundus examination showed vitreous haze with many pigmented materials. B-scan ultrasonography revealed a mass with low internal reflectivity and vitreous opacity. The eyeball was enucleated and a stage IIIA melanoma was confirmed by the pathologist...
July 2017: Taiwan Journal of Ophthalmology
https://www.readbyqxmd.com/read/29033536/spotlight-on-reticular-pseudodrusen
#15
REVIEW
Alessandro Rabiolo, Riccardo Sacconi, Maria Vittoria Cicinelli, Lea Querques, Francesco Bandello, Giuseppe Querques
Age-related macular degeneration (AMD) is a leading cause of vision loss in patients >50 years old. The hallmark of the disease is represented by the accumulation of extracellular material between retinal pigment epithelium and the inner collagenous layer of Bruch's membrane, called drusen. Although identified almost 30 years ago, reticular pseudodrusen (RPD) have been recently recognized as a distinctive phenotype. Unlike drusen, they are located in the subretinal space. RPD are strongly associated with late AMD, especially geographic atrophy, type 2 and 3 choroidal neovascularization, which, in turn, are less common in typical AMD...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/29032831/-extrascleral-extension-of-choroidal-melanoma-through-a-sclerotomy-site
#16
S Lemaître, L Lumbroso-Le Rouic, G Bataillon, N Cassoux
No abstract text is available yet for this article.
October 9, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/29030904/development-and-maintenance-of-the-brain-s-immune-toolkit-microglia-and-non-parenchymal-brain-macrophages
#17
REVIEW
Jose P Lopez-Atalaya, Katharine E Askew K, Amanda Sierra, Diego Gomez-Nicola
Microglia and non-parenchymal macrophages located in the perivascular space, the meninges and the choroid plexus are independent immune populations that play vital roles in brain development, homeostasis, and tissue healing. Resident macrophages account for a significant proportion of cells in the brain and their density remains stable throughout the lifespan thanks to constant turnover. Microglia develop from yolk sac progenitors, later evolving through intermediate progenitors in a fine-tuned process in which intrinsic factors and external stimuli combine to progressively sculpt their cell-type specific transcriptional profiles...
October 14, 2017: Developmental Neurobiology
https://www.readbyqxmd.com/read/29030613/lipopolysaccharide-enters-the-rat-brain-by-a-lipoprotein-mediated-transport-mechanism-in-physiological-conditions
#18
Alejandra Vargas-Caraveo, Aline Sayd, Sandra R Maus, Javier R Caso, José L M Madrigal, Borja García-Bueno, Juan C Leza
Physiologically, lipopolysaccharide (LPS) is present in the bloodstream and can be bound to several proteins for its transport (i.e.) LPS binding protein (LBP) and plasma lipoproteins). LPS receptors CD14 and TLR-4 are constitutively expressed in the Central Nervous System (CNS). To our knowledge, LPS infiltration in CNS has not been clearly demonstrated. A naturalistic experiment with healthy rats was performed to investigate whether LPS is present with its receptors in brain. Immunofluorescences showed that lipid A and core LPS were present in circumventricular organs, choroid plexus, meningeal cells, astrocytes, tanycytes and endothelial cells...
October 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29028172/influences-of-histidine-1-and-azaphenylalanine-4-on-the-affinity-anti-inflammatory-and-antiangiogenic-activities-of-azapeptide-cluster-of-differentiation-36-receptor-modulators
#19
Kelvine Chignen Possi, Mukandila Mulumba, Samy Omri, Yesica Garcia-Ramos, Houda Tahiri, Sylvain Chemtob, Huy Ong, William D Lubell
Azapeptide analogs of growth hormone releasing peptide-6 (GHRP-6) exhibit promising affinity, selectivity and modulator activity on the cluster of differentiation 36 receptor (CD36). For example, [A(1), azaF(4)]- and [azaY(4)]-GHRP-6 (1a and 2b) were previously shown to bind selectively to CD36, and exhibited respectively significant antiangiogenic and slight angiogenic activities in a microvascular sprouting assay using choroid explants. The influences of the 1- and 4-position residues on the affinity, anti-inflammatory and antiangiogenic activity of these azapeptides have now been studied in detail by the synthesis and analysis of a set of 25 analogs featuring Ala1 or His1 and a variety aromatic side chains at the aza-amino acid residue in the 4-position...
October 13, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29027964/microglia-and-monocytes-macrophages-polarization-reveal-novel-therapeutic-mechanism-against-stroke
#20
REVIEW
Masato Kanazawa, Itaru Ninomiya, Masahiro Hatakeyama, Tetsuya Takahashi, Takayoshi Shimohata
Stroke is a leading cause of morbidity and mortality worldwide, and consists of two types, ischemic and hemorrhagic. Currently, there is no effective treatment to increase the survival rate or improve the quality of life after ischemic and hemorrhagic stroke in the subacute to chronic phases. Therefore, it is necessary to establish therapeutic strategies to facilitate functional recovery in patients with stroke during both phases. Cell-based therapies, using microglia and monocytes/macrophages preconditioned by optimal stimuli and/or any therapies targeting these cells, might be an ideal therapeutic strategy for managing stroke...
October 13, 2017: International Journal of Molecular Sciences
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