keyword
MENU ▼
Read by QxMD icon Read
search

Choroiditis

keyword
https://www.readbyqxmd.com/read/28088658/exposure-to-chronic-early-life-stress-lastingly-alters-the-adipose-tissue-the-leptin-system-and-changes-the-vulnerability-to-western-style-diet-later-in-life-in-mice
#1
K Y Yam, E F G Naninck, M R Abbink, S E la Fleur, L Schipper, J C van den Beukel, A Grefhorst, A Oosting, E M van der Beek, P J Lucassen, A Korosi
Early-life stress (ES) increases the vulnerability to develop psychopathologies and cognitive decline in adulthood. Interestingly, this is often comorbid with metabolic disorders, such as obesity. However, it is unclear whether ES leads to lasting metabolic changes and to what extent this is associated with the ES-induced cognitive impairments. Here, we used an established chronic ES mouse model (from postnatal day (P) 2 to P9) to investigate the short- and long-term effects of ES exposure on parameters of the adipose tissue and the leptin system (i...
December 23, 2016: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28088625/absence-of-dj-1-causes-age-related-retinal-abnormalities-in-association-with-increased-oxidative-stress
#2
Vera L Bonilha, Brent A Bell, Mary E Rayborn, Ivy S Samuels, Anna King, Joe G Hollyfield, Chengsong Xie, Huaibin Cai
Oxidative stress alters physiological function in most biological tissues and can lead to cell death. In the retina, oxidative stress initiates a cascade of events leading to focal loss of RPE and photoreceptors, which is thought to be a major contributing factor to geographic atrophy. Despite these implications, the molecular regulation of RPE oxidative stress under normal and pathological conditions remains largely unknown. A better understanding of the mechanisms involved in regulating RPE and photoreceptors oxidative stress response is greatly needed...
January 11, 2017: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/28088509/choroidal-neovascularization-in-malattia-leventinese-diagnosed-using-optical-coherence-tomography-angiography
#3
Rita Serra, Florence Coscas, Nabil Messaoudi, Mayer Srour, Eric Souied
PURPOSE: To compare Optical Coherence Tomography Angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese DESIGN: Retrospective case series. METHODS: Eight eyes of four consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmological examination including color fundus photography, fluorescein and indocyanine green angiographies, Spectral Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28080168/corneal-melt-after-boston-keratoprosthesis-clinical-presentation-management-outcomes-and-risk-factor-analysis
#4
Soumaya Bouhout, Marie-Claude Robert, Sousans Deli, Mona Harissi-Dagher
PURPOSE: To determine the presentation, risk factors, and outcomes of keratolysis after Boston type I keratoprosthesis (B-KPro). METHODS: Retrospective chart review. RESULTS: A total of 16 (14%) of the 110 eyes (96 patients) which underwent B-KPro implantation developed keratolysis at an average 20 ± 11 months. Retroprosthetic membrane (RPM), infectious keratitis, and corneal dellen were identified in 31%, 25%, and 13% of corneal melts, respectively...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28080153/long-term-change-of-subfoveal-choroidal-thickness-in-beh%C3%A3-et-s-disease-patients-with-posterior-uveitis
#5
UnChul Park, In Hwan Cho, Sang Woong Moon, Hyeong Gon Yu
PURPOSE: To evaluate long-term changes of subfoveal choroidal thickness (SCT) in Behçet's disease (BD) patients with posterior uveitis. METHODS: Changes in SCT measured with enhanced depth imaging optical coherence tomography during quiescent phase were assessed during >24 months in 63 BD patients and control group. RESULTS: Baseline characteristics showed no difference, but the BD group showed poorer visual acuity (p = 0.013) and smaller SCT (p = 0...
January 12, 2017: Ocular Immunology and Inflammation
https://www.readbyqxmd.com/read/28079650/pneumatic-displacement-of-limited-traumatic-submacular-hemorrhage-without-tissue-plasminogen-activator-a-case-series
#6
Poornachandra Balughatta, Venkatesh Kadri, Sherine Braganza, Chaitra Jayadev, Ruchir A Mehta, Vikram Nakhate, Naresh K Yadav, Rohit Shetty
PURPOSE: To evaluate the efficacy of intravitreal gas (perfluoropropane, C3F8)-assisted displacement of submacular hemorrhage (SMH) secondary to recent or old blunt trauma. METHODS: An interventional case series of three patients who presented with SMH after blunt trauma, ranging from 2 days to 2 weeks back. All three patients were treated with an intravitreal injection of 0.3 cc of 100% C3F8 with anterior chamber paracentesis. Strict prone position was advised for 2 weeks with a minimum of 6 to 8 hours per day...
January 10, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28079023/incidence-and-growth-of-geographic-atrophy-during-5-years-of-comparison-of-age-related-macular-degeneration-treatments-trials
#7
Juan E Grunwald, Maxwell Pistilli, Ebenezer Daniel, Gui-Shuang Ying, Wei Pan, Glenn J Jaffe, Cynthia A Toth, Stephanie A Hagstrom, Maureen G Maguire, Daniel F Martin
PURPOSE: To estimate the incidence, size, and growth rate of geographic atrophy (GA) during 5 years of follow-up among participants in the Comparison of Age-Related Macular Degeneration Treatments Trials (CATT). DESIGN: Cohort within a clinical trial. PARTICIPANTS: Participants included in CATT. METHODS: A total of 1185 CATT participants were randomly assigned to ranibizumab or bevacizumab treatment and to 3 treatment regimens...
January 2017: Ophthalmology
https://www.readbyqxmd.com/read/28078992/smoking-and-eye-pathologies-a-systemic-review-part-ii-retina-diseases-uveitis-optic-neuropathies-thyroid-associated-orbitopathy
#8
Małgorzata Nita, Andrzej Grzybowski
BACKGROUND: Tobacco smoking has detrimental influence on human health. AIM: The analysis of influence of tobacco smoking on retina diseases, uveitis, optic neuropathies, and thyroid-associated orbitopathy in adults and children. METHODS: A comprehensive review of the literature performed through MEDLINE and PubMed searches, covering the years 2000-2016. RESULTS: In adults, tobacco smoking is a strong risk factor for age-related macular degeneration, polypoidal choroidal vasculopathy, uveitis and inflamed cystoid macular edema as well as Grave`s ophthalmopathy...
January 10, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/28078103/the-potential-of-spectral-domain-optical-coherence-tomography-imaging-based-retinal-biomarkers
#9
REVIEW
Prateep Phadikar, Sandeep Saxena, Surabhi Ruia, Timothy Y Y Lai, Carsten H Meyer, Dean Eliott
BACKGROUND: Biomarker", a merged word of "biological marker", refers to a broad subcategory of medical signs that objectively indicate the state of health, and well-being of an individual. Biomarkers hold great promise for personalized medicine as information gained from diagnostic or progression markers can be used to tailor treatment to the individual for highly effective intervention in the disease process. Optical coherence tomography (OCT) has proved useful in identifying various biomarkers in ocular and systemic diseases...
2017: International Journal of Retina and Vitreous
https://www.readbyqxmd.com/read/28077397/relationships-between-flortaucipir-pet-tau-binding-and-amyloid-burden-clinical-diagnosis-age-and-cognition
#10
Michael J Pontecorvo, Michael D Devous, Michael Navitsky, Ming Lu, Stephen Salloway, Frederick W Schaerf, Danna Jennings, Anupa K Arora, Anne McGeehan, Nathaniel C Lim, Hui Xiong, Abhinay D Joshi, Andrew Siderowf, Mark A Mintun
The advent of tau-targeted positron emission tomography tracers such as flortaucipir ((18)F-AV-1451, also known as (18)F-T807) have made it possible to investigate the sequence of development of tau and amyloid-β in relationship to age, and to the development of cognitive impairment due to Alzheimer's disease. In this study, flortaucipir tau and florbetapir amyloid positron emission tomography were obtained for 217 subjects including 16 young and 58 older cognitively normal subjects, 95 subjects with mild cognitive impairment (Mini-Mental State Examination 24-30) and 48 subjects with clinically-defined possible or probable Alzheimer's disease (Mini-Mental State Examination >10)...
January 11, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28076857/the-journey-of-geographic-atrophy-through-past-present-and-future
#11
Steffen Schmitz-Valckenberg
"Geographic atrophy" is a concise term that has been firmly established for the description of the end-stage manifestation of nonexudative age-related macular degeneration (AMD). "Geographic lesions" resembling sharply demarcated continents on a map have been originally described in the German literature in 1854 (landkartenartiger/inselförmiger Zungenfratt) for a manifestation later called "geographic tongue" in English. In 1970, Gass was the first to describe "geographic areas of atrophy" in "senile macular choroidal degeneration...
January 12, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28076572/iris-metastases-from-systemic-cancer-a-report-of-three-cases
#12
Patrícia Correa de Mello, Oswaldo Ferreira Moura Brasil, André Vidoris, Melina Correia Morales, Rubens N Belfort
Ocular metastasis is relatively uncommon, with a reported incidence of approximately 8%, according to the results of autopsy evaluation. The majority of ocular metastases are located within the choroid, while metastatic tumors affecting the iris are rare. Metastatic tumors may manifest as stromal nodules or ill-defined iris thickening, or they may present with nonspecific features such as pain, iridocyclitis, and hyphema. Here, we describe three patients with iris metastasis and discuss the diagnostic challenges and unusual findings associated with these cases...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28076569/optical-coherence-tomography-of-macular-atrophy-associated-with-microcephaly-and-presumed-intrauterine-zika-virus-infection
#13
Adriana Gondim de Moura Campos, Rodrigo Pessoa Cavalcanti Lira, Tiago Eugenio Faria E Arantes
This case report describes the retinal optical coherence tomography (OCT) findings in a microcephalic infant with macular atrophy presumably caused by intrauterine Zika virus infection. OCT demonstrated atrophy of the outer retinal layers and choriocapillaris, including the outer nuclear layer and ellipsoid zone, associated with retinal pigment epithelium hyper-reflectivity and increased OCT penetration into deeper layers of the choroid and sclera. A major concern associated with this infection is the apparent increased incidence of microcephaly in fetuses born to mothers infected with the Zika virus...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28076568/immunohistochemical-analysis-of-retinoblastoma-cell-phenotype-using-neuronal-and-glial-cell-markers
#14
María Eugenia Orellana, Rubens Belfort, Emilia Antecka, Miguel Noel Burnier
Purpose: The cellular origin of retinoblastoma is uncertain as constituent tumor cells heterogeneously express markers of both immature and mature retinal cells. An immunohistochemical analysis of cellular origin may yield valuable insights into disease progression and treatment options. This study aimed to determine the cellular origin of retinoblastoma in a large case series and correlate these findings with histopathological prognostic factors. Methods: Thirty-nine retinoblastoma cases were histopathologically diagnosed and analyzed by immunohistochemistry using monoclonal antibodies against the immature neural cell marker SRY-box containing gene 2 (SOX-2), the mature neuronal cell marker microtubule-associated protein 2 (MAP2), and the mature glial cell marker glial fibrillary acidic protein (GFAP)...
November 2016: Arquivos Brasileiros de Oftalmologia
https://www.readbyqxmd.com/read/28076442/subfoveal-choroidal-thickness-in-central-serous-chorioretinopathy-a-meta-analysis
#15
Guohai Chen, Radouil Tzekov, Wensheng Li, Fangzheng Jiang, Sihong Mao, Yuhua Tong
PURPOSE: To evaluate the relationship between subfoveal choroidal thickness (SFCT) and eyes with central serous chorioretinopathy (CSC) versus fellow or control eyes. METHODS: We performed a meta-analysis using databases including PubMed, Embase and ISI Web of Science to find relevant studies. Weighted mean difference (WMD) was calculated for the SFCT in CSC eyes, the unaffected fellow eyes and normal controls. RESULTS: Twelve studies were selected for this meta-analysis, including 1108 eyes (397 CSC eyes, 228 unaffected fellow eyes and 483 eyes of normal controls)...
2017: PloS One
https://www.readbyqxmd.com/read/28074532/pathogenesis-of-developmental-anomalies-of-the-central-nervous-system-induced-by-congenital-cytomegalovirus-infection
#16
REVIEW
Hideya Kawasaki, Isao Kosugi, Shiori Meguro, Toshihide Iwashita
In humans, the herpes virus family member cytomegalovirus (CMV) is the most prevalent mediator of intrauterine infection-induced congenital defect. Central nervous system (CNS) dysfunction is a distinguishing symptom of CMV infection, and characterized by ventriculoencephalitis and microglial nodular encephalitis. Reports on the initial distribution of CMV particles and its receptors on the blood brain barrier (BBB) are rare. Nevertheless, several factors are suggested to affect CMV etiology. Viral particle size is the primary factor in determining the pattern of CNS infections, followed by the expression of integrin β1 in endothelial cells, pericytes, meninges, choroid plexus, and neural stem progenitor cells (NSPCs), which are the primary targets of CMV infection...
January 10, 2017: Pathology International
https://www.readbyqxmd.com/read/28067754/moderate-renal-failure-accentuates-t1-signal-enhancement-in-the-deep-cerebellar-nuclei-of-gadodiamide-treated-rats
#17
Marlène Rasschaert, Jean-Marc Idée, Philippe Robert, Nathalie Fretellier, Véronique Vives, Xavier Violas, Sébastien Ballet, Claire Corot
OBJECTIVES: The purpose of this preclinical study was to investigate whether moderate chronic kidney disease is a factor in potentiating gadolinium (Gd) uptake in the brain. MATERIALS AND METHODS: A comparative study was performed on renally impaired (subtotal nephrectomy) rats versus rats with normal renal function. The animals received 4 daily injections of 0.6 mmol Gd/kg a week for 5 weeks (cumulative dose of 12 mmol Gd/kg) of gadodiamide or saline solution. The MR signal enhancement in the deep cerebellar nuclei was monitored by weekly magnetic resonance imaging examinations...
November 28, 2016: Investigative Radiology
https://www.readbyqxmd.com/read/28067724/acute-central-serous-chorioretinopathy-factors-influencing-episode-duration
#18
Alejandra Daruich, Alexandre Matet, Laetitia Marchionno, Jean-Dominique De Azevedo, Aude Ambresin, Irmela Mantel, Francine Behar-Cohen
PURPOSE: To evaluate the influence of clinical and multimodal imaging parameters on the duration of acute central serous chorioretinopathy (CSCR) episodes. METHODS: Consecutive patients with first, treatment-naïve central serous chorioretinopathy episodes presenting within 20 days of symptoms onset were prospectively included. They were reevaluated 15 days to 20 days later, followed by monthly evaluation for 6 months. Subfoveal choroidal thickness (SFCT), fluorescein leakage intensity on fluorescein angiography, elevation of retinal pigment epithelium (RPE) lesions at leakage sites, focal/multifocal pattern of indocyanine green angiography (ICGA) at baseline, time-dependent pattern of subretinal fluid (SRF) resorption on OCT using volume segmentation, history of corticosteroid intake and mean blood pressure were evaluated using univariate (Log rank test) and multivariate (Cox proportional hazard regression) survival analysis...
January 6, 2017: Retina
https://www.readbyqxmd.com/read/28067720/swept-source-optical-coherence-tomography-evaluation-of-chorioretinal-changes-in-hypertensive-choroidopathy-related-to-hellp-syndrome
#19
Daniel Velazquez-Villoria, Pablo Marti Rodrigo, Maria L DeNicola, Miguel A Zapata Vitori, Antonio Segura García, Jose García-Arumí
PURPOSE: To report a case of hypertensive choroidopathy with detailed chorioretinal images obtained using swept source optical coherence tomography. METHODS: We report the case of a 36-year-old pregnant woman who presented with extensive bilateral exudative retinal detachments (visual acuity of hands movement bilaterally), high blood pressure, and severe alteration of the laboratory test results resulting in the diagnosis of HELLP syndrome. The baby was delivered by emergency cesarean section and the patient was hospitalized in the intensive care unit...
January 6, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28064423/pathophysiology-diagnosis-and-management-of-glaucoma-associated-with-sturge-weber-syndrome
#20
REVIEW
Usman Javaid, Muhammad Hassaan Ali, Samreen Jamal, Nadeem Hafeez Butt
PURPOSE: Sturge-Weber syndrome (SWS), also known as encephalotrigeminal angiomatosis, is a condition which includes leptomeningeal hemangioma, facial angiomatosis or nevus flammeus, and ocular changes. SWS can lead to severe complications of anterior segment involving conjunctiva and eyelids, whereas posterior segment of the eye may also be affected by diffuse choroidal hemorrhages. This article was written with the objectives to determine the pathophysiology, diagnosis, and treatment of glaucoma associated with this rare and challenging disorder...
January 7, 2017: International Ophthalmology
keyword
keyword
46606
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"