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https://www.readbyqxmd.com/read/28544778/differential-regulation-of-protein-tyrosine-kinase-signaling-by-dock-and-the-ptp61f-variants
#1
Lee F Willoughby, Jan Manent, Kirsten Allan, Han Lee, Marta Portela, Florian Wiede, Coral Warr, Tzu-Ching Meng, Tony Tiganis, Helena E Richardson
Tyrosine phosphorylation-dependent signalling is coordinated by the opposing actions of protein tyrosine kinases (PTKs) and protein tyrosine phosphatases (PTPs). There is a growing list of adaptor proteins that interact with PTPs and facilitate the dephosphorylation of substrates. The extent to which any given adaptor confers selectivity for any given substrate in vivo remains unclear. Here we have taken advantage of Drosophila melanogaster as a model organism to explore the influence of the SH3/SH2 adaptor protein Dock on the abilities of the membrane (PTP61Fm)- and nuclear (PTP61Fn)-targeted variants of PTP61F (the Drosophila othologue of the mammalian enzymes PTP1B and TCPTP respectively) to repress PTK signaling pathways in vivo...
May 23, 2017: FEBS Journal
https://www.readbyqxmd.com/read/28543813/inhaled-pulmonary-vasodilator-therapy-for-management-of-right-ventricular-dysfunction-after-left-ventricular-assist-device-placement-and-cardiac-transplantation
#2
Leah A Sabato, David M Salerno, Jeremy D Moretz, Douglas L Jennings
Right ventricular failure (RVF) after cardiac transplant (CTX) or implantation of a continuous-flow left ventricular assist device (CF-LVAD) is associated with significant post-operative morbidity and mortality. A variety of modalities have been used to treat post-operative RVF, including management of volume status, intravenous inotropes and vasodilators, and right-sided mechanical support. Inhaled vasodilator agents are a unique treatment option aimed at minimizing systemic absorption by delivering therapy directly to the pulmonary vasculature...
May 24, 2017: Pharmacotherapy
https://www.readbyqxmd.com/read/28537696/electron-microscopic-changes-of-detrusor-in-benign-enlargement-of-prostate-and-its-clinical-correlation
#3
Sher Singh Yadav, Rohit Bhattar, Lokesh Sharma, Gautam Banga, Trilok Chandra Sadasukhi
AIMS: To study the ultra structural changes in bladder musculature in cases of BPE and their clinical relevance. MATERIAL AND METHODS: In this descriptive longitudinal, controlled, observational study patients were enrolled into three groups, group 1, group 2A and group 2B. Control group (group-1) consisted of age matched normal male patients, who underwent surveillance or diagnostic cystoscopy for microscopic hematuria or irritative symptoms. Case group (group-2) comprised of patients with BPE, undergoing TURP...
May 23, 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
https://www.readbyqxmd.com/read/28533577/the-interaction-between-trolox-and-4-4-diisothiocyanatostilbene-2-2-disulfonic-acid-on-hypoxic-pulmonary-vasoconstriction-in-the-isolated-rabbit-lung
#4
Somayh Mansoori, Seyed Mostafa Shid Moosavi, Farzaneh Ketabchi
BACKGROUND: The mechanism of hypoxic pulmonary vasoconstriction (HPV) is still debatable. It has been proposed that reactive oxygen species (ROS) might be involved in HPV. However, there is no special transporter for superoxide anion in the cell membrane and it may release from the cells via anion exchanger. Therefore, the aim of this study was to investigate the interaction of ROS and anion exchanger in acute HPV. METHODS: The present study was performed in the isolated rabbit lung...
May 2017: Iranian Journal of Medical Sciences
https://www.readbyqxmd.com/read/28521513/astragalus-polysaccharides-attenuate-monocrotaline-induced-pulmonary-arterial-hypertension-in-rats
#5
Lin-Bo Yuan, Chun-Yan Hua, Sheng Gao, Ya-Ling Yin, Mao Dai, Han-Yan Meng, Piao-Piao Li, Zhong-Xin Yang, Qing-Hua Hu
Astragalus polysaccharides (APS) have been shown to possess a variety of biological activities including anti-oxidant and anti-inflammation functions in a number of diseases. However, their function in pulmonary arterial hypertension (PAH) is still unknown. Rats received APS (200[Formula: see text]mg/kg once two days) for 2 weeks after being injected with monocrotaline (MCT; 60[Formula: see text]mg/kg). The pulmonary hemodynamic index, right ventricular hypertrophy, and lung morphological features of the rat models were examined, as well as the NO/eNOS ratio of wet lung and dry lung weight and MPO...
May 18, 2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/28514643/yorkie-regulates-epidermal-wound-healing-in-drosophila-larvae-independently-of-cell-proliferation-and-apoptosis
#6
Chang-Ru Tsai, Aimee E Anderson, Sirisha Burra, Juyeon Jo, Michael J Galko
Yorkie (Yki), the transcriptional co-activator of the Hippo signaling pathway, has well-characterized roles in balancing apoptosis and cell division during organ growth control. Yki is also required in diverse tissue regenerative contexts. In most cases this requirement reflects its well-characterized roles in balancing apoptosis and cell division. Whether Yki has repair functions outside of the control of cell proliferation, death, and growth is not clear. Here we show that Yki and Scalloped (Sd) are required for epidermal wound closure in the Drosophila larval epidermis...
May 14, 2017: Developmental Biology
https://www.readbyqxmd.com/read/28514266/pulmonary-vascular-function-and-aerobic-exercise-capacityat-moderate-altitude
#7
Vitalie Faoro, Gael Deboeck, Marco Vicenzi, Anne-Fleur Gaston, Bamodi Simaga, Grégory Doucende, Ilona Hapkova, Emma Roca, Enric Subirats, Fabienne Durand, Robert Naeije
PURPOSE: There has been suggestion that a greater "pulmonary vascular reserve" defined by a low pulmonary vascular resistance (PVR) and a high lung diffusing capacity (DL) allows for a superior aerobic exercise capacity. How pulmonary vascular reserve might affect exercise capacity at moderate altitude is not known. METHODS: Thirty-eight healthy subjects underwent an exercise stress echocardiography of the pulmonary circulation, combined with measurements of DL for nitric oxide (NO) and carbon monoxide (CO) and a cardio-pulmonary exercise test at sea level and at the altitude of 2250m...
May 17, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28510688/two-component-systems-required-for-virulence-in-pseudomonas-aeruginosa
#8
V I Francis, E C Stevenson, S L Porter
Pseudomonas aeruginosa is a versatile opportunistic pathogen capable of infecting a broad range of hosts, in addition to thriving in a broad range of environmental conditions outside of hosts. With this versatility comes the need to tightly regulate its genome to optimise its gene expression and behaviour to the prevailing conditions. Two-component systems (TCSs) comprising sensor kinases and response regulators, play a major role in this regulation. This minireview discusses the growing number of two-component systems that have been implicated in the virulence of Pseudomonas aeruginosa, with a special focus on the emerging theme of multikinase networks, which are networks comprising multiple sensor kinases working together, sensing and integrating multiple signals to decide upon the best response...
May 16, 2017: FEMS Microbiology Letters
https://www.readbyqxmd.com/read/28503470/falsely-elevated-postvoid-residual-urine-volume-in-uterine-myoma
#9
Tae Hee Kim, Hyo Sang Kim, Jung Wook Park, Oh Kyung Lim, Ki Deok Park, Ju Kang Lee
Precise measurement of postvoid residual (PVR) urine volume is a key factor in assessing patients with voiding dysfunction, including those with lower urinary tract problems. The safe and noninvasive ultrasound bladder scan is the preferred mode to measure PVR volume. However, this procedure has a false-positive rate up to 9%, in the presence of ovarian cysts, renal cysts, ascites, or uterine myoma with cystic degeneration. Until now, cystic lesions are known to cause false positivity in ultrasound bladder scanner...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28503452/relation-of-urinary-retention-and-functional-recovery-in-stroke-patients-during-rehabilitation-program
#10
Seok Beom Son, Seong Yun Chung, Seok Kang, Joon Shik Yoon
OBJECTIVE: To investigate the relationship between urinary retention and short-term functional recovery in subacute stage after stroke. METHODS: The medical records of 94 patients admitted to the rehabilitation unit of Korea University Guro Hospital were reviewed retrospectively. The postvoid residual urine (PVR) was measured at least once a day using a bladder scan, and urinary retention (UR) was defined when the daily PVR volume consistently checked more than 100 mL...
April 2017: Annals of Rehabilitation Medicine
https://www.readbyqxmd.com/read/28496549/phosphodiesterase-5-inhibitors-improve-clinical-outcomes-exercise-capacity-and-pulmonary-hemodynamics-in-patients-with-heart-failure-with-reduced-left-ventricular-ejection-fraction-a-meta-analysis
#11
Renato De Vecchis, Arturo Cesaro, Carmelina Ariano, Anna Giasi, Carmela Cioppa
BACKGROUND: Several studies have compared the use of phosphodiesterase-5 (PDE5) inhibitors sildenafil or udenafil with the placebo in patients suffering from pulmonary hypertension (PH) due to left chronic heart failure (CHF), corresponding to group 2 (PH due to left heart disease) of the PH classification (according to 2015 ESC/ERS guidelines for the diagnosis and treatment of PH). The results of the use of PDE5 inhibitors in the PH due to left heart disease were inconsistent and heterogeneous...
June 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28493606/micrornas-as-potential-biomarkers-to-predict-the-risk-of-urinary-retention-following-intradetrusor-onabotulinumtoxin-a-injection
#12
Christopher J Chermansky, Brian T Kadow, Mahendra Kashyap, Pradeep Tyagi
AIMS: MicroRNAs (miRs) control post-transcriptional gene expression, and this is relevant in understanding better chronic diseases and treatment outcomes. The role of miRs in the pathology and treatment outcomes of overactive bladder (OAB) is unknown. In this study, we assessed the differential expression of miRs in OAB patients responding with either normal or elevated post-void residual volumes (PVRs) ≥200 mL following intradetrusor injection of onabotulinumtoxin-A (onaBoNT-A). METHODS: Female OAB patients refractory to OAB drugs were consented for this study...
May 11, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/28483481/-outcomes-of-greenlight-xps-180w-laser-photovaporization-for-bph-larger-than-80ml
#13
M Thoulouzan, M-A Perrouin-Verbe, J Calves, C Deruelle, V Joulin, A Valeri, G Fournier
AIM: To evaluate the results of GreenLight XPS photovaporization (PVP/XPS) with intraoperative transrectal ultrasonographic monitoring for the treatment of large Benign Prostatic Hyperplasia (BPH) (>80mL). PATIENTS AND METHODS: Operative and perioperative data of 82 patients were collected prospectively. Complications and functional outcomes (IPSS, quality of life (QoL) score, maximal flow rate and post-void residual (PVR)) were evaluated at 1, 3, 12 months post-operatively prostate volume and PSA were assessed at 3 and 12 months post-operatively...
May 5, 2017: Progrès en Urologie
https://www.readbyqxmd.com/read/28482627/improvement-of-pulmonary-arterial-compliance-and-further-pulmonary-hemodynamic-effects-of-serelaxin-in%C3%A2-a%C3%A2-sheep-model
#14
René Schiffner, Juliane Reiche, Martin Schmidt, Christian Jung, Sebastian Walther, Andrey Irintchev, Sabine J Bischoff
BACKGROUND: The influence of the recombinant form of human relaxin-2 (serelaxin) on pulmonary hemodynamics under physiologic conditions have not been the subject of studies in an animal model up until now. METHODS: We therefore utilised the large animal model sheep, convenient in its similar cardiovascular physiology, to investigate said influence. All animals underwent right heart catheterization, a safe and reliable invasive procedure for the assessment of pulmonary hemodynamics, and then received either 30μg/kg serelaxin (n = 11) or saline (n = 13)...
May 2, 2017: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/28476520/distinctive-metabolomic-fingerprint-in-scleroderma-patients-with-pulmonary-arterial-hypertension
#15
Martino Deidda, Cristina Piras, Christian Cadeddu Dessalvi, Emanuela Locci, Luigi Barberini, Susanne Orofino, Mario Musu, Mario Nicola Mura, Paolo Emilio Manconi, Gabriele Finco, Luigi Atzori, Giuseppe Mercuro
BACKGROUND: Pulmonary arterial hypertension (PAH) in systemic sclerosis (SS) identifies a poor prognosis subset of patients. Recent studies suggested a "metabolic theory" on the development of pulmonary arterial hypertension. On this basis we performed a metabolomic study in order to evaluate whether differences in pulmonary arterial blood metabolites were identifiable in SS patients with increased pulmonary vascular resistance (PVR). METHODS: We studied 18 SS patients (age 58...
April 19, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28474349/refined-balloon-pulmonary-angioplasty-a-therapeutic-option-in-very-elderly-patients-with-chronic-thromboembolic-pulmonary-hypertension
#16
Marek Roik, Dominik Wretowski, Andrzej Łabyk, Katarzyna Irzyk, Barbara Lichodziejewska, Olga Dzikowska-Diduch, Dorota Piotrowska-Kownacka, Piotr Pruszczyk
INTRODUCTION/OBJECTIVES: Balloon pulmonary angioplasty (BPA) is a developing treatment for inoperable chronic thromboembolic pulmonary hypertension (CTEPH). However, to our knowledge there are no published data on BPA in CTEPH subjects aged 75 or over. The aim of the study was to analyze clinical and hemodynamic outcomes of sequential BPA in very elderly patients disqualified from pulmonary endarterectomy (PEA). PATIENTS AND METHODS: We enrolled 10 patients (4 male, 6 female, median age 81 [75-88]) with confirmed CTEPH, mPAP > 30 mmHg, and WHO class > II, disqualified from PEA...
May 5, 2017: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/28474112/transperineal-laser-ablation-for-percutaneous-treatment-of-benign-prostatic-hyperplasia-a-feasibility-study
#17
Gianluigi Patelli, Antonio Ranieri, Aurelio Paganelli, Giovanni Mauri, Claudio Maurizio Pacella
PURPOSE: To assess the feasibility and safety of transperineal laser ablation (TPLA) for treating benign prostatic hyperplasia (BPH). MATERIALS AND METHODS: Institutional review board approval was obtained for this prospective non-randomized trial. Eightteen patients (age 71.7 ± 9.4 years) with urinary symptoms secondary to BPH underwent TPLA under local anesthesia. Under US guidance, up to four 21G applicators were inserted in the prostatic tissue. Each treatment was performed with diode laser operating at 1064 nm changing the illumination time according to prostate size...
May 4, 2017: Cardiovascular and Interventional Radiology
https://www.readbyqxmd.com/read/28471090/the-prognostic-importance-of-the-diastolic-pulmonary-gradient-transpulmonary-gradient-and-pulmonary-vascular-resistance-in-patients-undergoing-transcatheter-aortic-valve-replacement
#18
Nathan W Brunner, Su Fei Yue, Dion Stub, Jian Ye, Anson Cheung, Jonathon Leipsic, Sandra Lauck, Danny Dvir, Gidon Perlman, Nay Htun, Peter Fahmy, Roshan Prakash, Lim Eng, Kevin Ong, Michael Tsang, John A Cairns, John G Webb, David A Wood
OBJECTIVES: To evaluate the association between markers of precapillary pulmonary hypertension (PH) and survival in transcatheter aortic valve replacement (TAVR). BACKGROUND: The importance of precapillary PH has been sparsely investigated in patients undergoing TAVR. It may prove an important risk factor for poor outcomes. METHODS: We identified patients at our institution undergoing TAVR with a baseline right heart catheterization (RHC) demonstrating PH...
May 4, 2017: Catheterization and Cardiovascular Interventions
https://www.readbyqxmd.com/read/28466974/visualization-recording-and-storage-of-pressure-distribution-through-a-smart-matrix-based-on-the-piezotronic-effect
#19
Xun Han, Weiming Du, Mengxiao Chen, Xiandi Wang, Xiaojia Zhang, Xiaoyi Li, Jing Li, Zhengchun Peng, Caofeng Pan, Zhong Lin Wang
Pressure sensors that can both directly visualize and record applied pressure/stress are essential for e-skin and medical/health monitoring. Here, using a WO3 -film electrochromic device (ECD) array (10 × 10 pixels) and a ZnO-nanowire-matrix pressure sensor (ZPS), a pressure visualization and recording (PVR) system with a spatial resolution of 500 µm is developed. The distribution of external pressures can be recorded through the piezotronic effect from the ZPS and directly expressed by color changes in the ECD...
May 3, 2017: Advanced Materials
https://www.readbyqxmd.com/read/28464427/pulmonary-hypertension-due-to-left-heart-disease-analysis-of-survival-according-to-the-haemodynamic-classification-of-the-2015-esc-ers-guidelines-and-insights-for-future-changes
#20
Massimiliano Palazzini, Fabio Dardi, Alessandra Manes, Maria L Bacchi Reggiani, Enrico Gotti, Andrea Rinaldi, Alessandra Albini, Enrico Monti, Nazzareno Galiè
AIMS: Pulmonary hypertension (PH) is a relevant complication of left heart disease (LHD). The 2015 ESC/ERS PH guidelines report two different haemodynamic subsets of PH due to LHD (PH-LHD) based on levels of pulmonary vascular resistance (PVR) and diastolic pressure gradient (DPG): isolated post-capillary PH (Ipc-PH) and combined post- and pre-capillary PH (Cpc-PH). The objective of this study is to evaluate the prognostic value of Ipc-PH and Cpc-PH. METHODS AND RESULTS: Data from 276 consecutive incident patients with PH-LHD were included...
May 2, 2017: European Journal of Heart Failure
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