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https://www.readbyqxmd.com/read/27612729/research-on-a-zn-cu-alloy-as-a-biodegradable-material-for-potential-vascular-stents-application
#1
Jialin Niu, Zibo Tang, Hua Huang, Jia Pei, Hua Zhang, Guangyin Yuan, Wenjiang Ding
Zn-based alloys have been viewed as new potential materials for biodegradable implants, such as cardiovascular stents, mainly in consideration of their lower corrosion rate when compared with that of Mg alloys. In this study we developed a new Zinc-4wt.%Copper (Zn-4Cu) alloy as a biodegradable material. Hot extrusion was applied to Zn-4Cu to refine the microstructure and consequently improve its mechanical properties and corrosion resistance. After extrusion, dendritic CuZn5 phases were broken and distributed along the extrusion direction...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/27248371/bioabsorbable-zinc-ion-induced-biphasic-cellular-responses-in-vascular-smooth-muscle-cells
#2
Jun Ma, Nan Zhao, Donghui Zhu
Bioabsorbable metal zinc (Zn) is a promising new generation of implantable scaffold for cardiovascular and orthopedic applications. In cardiovascular stent applications, zinc ion (Zn(2+)) will be gradually released into the surrounding vascular tissues from such Zn-containing scaffolds after implantation. However, the interactions between vascular cells and Zn(2+) are still largely unknown. We explored the short-term effects of extracellular Zn(2+) on human smooth muscle cells (SMCs) up to 24 h, and an interesting biphasic effect of Zn(2+) was observed...
2016: Scientific Reports
https://www.readbyqxmd.com/read/27094868/biodegradable-metals-for-cardiovascular-stents-from-clinical-concerns-to-recent-zn-alloys
#3
Patrick K Bowen, Emily R Shearier, Shan Zhao, Roger J Guillory, Feng Zhao, Jeremy Goldman, Jaroslaw W Drelich
Metallic stents are used to promote revascularization and maintain patency of plaqued or damaged arteries following balloon angioplasty. To mitigate the long-term side effects associated with corrosion-resistant stents (i.e., chronic inflammation and late stage thrombosis), a new generation of so-called "bioabsorbable" stents is currently being developed. The bioabsorbable coronary stents will corrode and be absorbed by the artery after completing their task as vascular scaffolding. Research spanning the last two decades has focused on biodegradable polymeric, iron-based, and magnesium-based stent materials...
May 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27031652/transition-metal-mediated-release-of-nitric-oxide-no-from-s-nitroso-n-acetyl-d-penicillamine-snap-potential-applications-for-endogenous-release-of-no-at-the-surface-of-stents-via-corrosion-products
#4
Connor W McCarthy, Roger J Guillory, Jeremy Goldman, Megan C Frost
Nitric oxide (NO), identified over the last several decades in many physiological processes and pathways as both a beneficial and detrimental signaling molecule, has been the subject of extensive research. Physiologically, NO is transported by a class of donors known as S-nitrosothiols. Both endogenous and synthetic S-nitrosothiols have been reported to release NO during interactions with certain transition metals, primarily Cu(2+) and Fe(2+). Ag(+) and Hg(2+) have also been identified, although these metals are not abundantly present in physiological systems...
April 27, 2016: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/26249616/metallic-zinc-exhibits-optimal-biocompatibility-for-bioabsorbable-endovascular-stents
#5
Patrick K Bowen, Roger J Guillory, Emily R Shearier, Jan-Marten Seitz, Jaroslaw Drelich, Martin Bocks, Feng Zhao, Jeremy Goldman
Although corrosion resistant bare metal stents are considered generally effective, their permanent presence in a diseased artery is an increasingly recognized limitation due to the potential for long-term complications. We previously reported that metallic zinc exhibited an ideal biocorrosion rate within murine aortas, thus raising the possibility of zinc as a candidate base material for endovascular stenting applications. This study was undertaken to further assess the arterial biocompatibility of metallic zinc...
November 1, 2015: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/26224391/effectiveness-of-biodegradable-magnesium-alloy-stents-in-coronary-artery-and-femoral-artery
#6
Yunan Yue, Lili Wang, Nuo Yang, Jinglin Huang, Licheng Lei, Huiming Ye, Lihui Ren, Shuixiang Yang
OBJECTIVES: To access the biocompatibility, effectiveness, and safety of biodegradable magnesium (Mg) alloy stent (BMAS) in the coronary artery and femoral artery. BACKGROUND: Atherosclerosis is a lesion of cardiovascular system, including the diseases in heart and blood vessels. METHODS: The aluminum (Al) and zinc (Zn)-based BMAS was designed by cold drawing methods. Forty healthy immunized mongrel dogs were randomly divided into 8 groups...
August 2015: Journal of Interventional Cardiology
https://www.readbyqxmd.com/read/26172399/recent-advances-in-biodegradable-metals-for-medical-sutures-a-critical-review
#7
REVIEW
Jan-Marten Seitz, Martin Durisin, Jeremy Goldman, Jaroslaw W Drelich
Sutures that biodegrade and dissolve over a period of several weeks are in great demand to stitch wounds and surgical incisions. These new materials are receiving increased acceptance across surgical procedures whenever permanent sutures and long-term care are not needed. Unfortunately, both inflammatory responses and adverse local tissue reactions in the close-to-stitching environment are often reported for biodegradable polymeric sutures currently used by the medical community. While bioabsorbable metals are predominantly investigated and tested for vascular stent or osteosynthesis applications, they also appear to possess adequate bio-compatibility, mechanical properties, and corrosion stability to replace biodegradable polymeric sutures...
September 16, 2015: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/25690931/in-vitro-interactions-of-blood-platelet-and-fibroblast-with-biodegradable-magnesium-zinc-strontium-alloys
#8
T Y Nguyen, A F Cipriano, Ren-Guo Guan, Zhan-Yong Zhao, Huinan Liu
Magnesium (Mg) alloy is an attractive class of metallic biomaterial for cardiovascular applications due to its biodegradability and mechanical properties. In this study, we investigated the degradation in blood, thrombogenicity, and cytocompatibility of Magnesium-Zinc-Strontium (Mg-Zn-Sr) alloys, specifically four Mg-4 wt % Zn-xSr (x = 0.15, 0.5, 1, and 1.5 wt %) alloys, together with pure Mg control and relevant reference materials for cardiovascular applications. Human whole blood and platelet rich plasma (PRP) were used as the incubation media to investigate the degradation behavior of the Mg-Zn-Sr alloys...
September 2015: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/24440188/characterization-of-the-kallikrein-kinin-system-metalloproteinases-and-their-tissue-inhibitors-in-the-in-stent-restenosis-after-peripheral-percutaneous-angioplasty
#9
Maurício S Ribeiro, Renata Dellalibera-Joviliano, Christiane Becari, Felipe Roberti Teixeira, Paula Vasconcelos Araujo, Carlos E Piccinato, Cesar Presto Campos, Paulo Roberto B Evora, Edwaldo E Joviliano
BACKGROUND: The kallikrein-kinin system (KKS) has several direct and indirect effects on cells and cellular mediators involved in the inflammatory process. Studies about inflammation on percutaneous transluminal angioplasty with stent (PTA/stent) to treat peripheral arterial disease (PAD) in humans are scarce. The matrix metalloproteinases (MMPs) are calcium-dependent zinc-containing endopeptidases expressed in various cells and tissues such as fibroblasts, inflammatory cells, and, smooth muscle cells...
May 2014: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/24243223/in-vitro-and-in-vivo-assessment-of-the-biocompatibility-of-an-mg-6z-n-alloy-in-the-bile
#10
Yigang Chen, Jun Yan, Changli Zhao, Shaoxiang Zhang, Song Yu, Zigang Wang, Xiaohu Wang, Xiaonong Zhang, Qi Zheng
There is a great clinical need for biodegradable bile duct stents. Biodegradable stents made of an Mg-6Zn alloy were investigated in both vivo animal experiment and in vitro cell experiments. During the in vivo experiments, blood biochemical tests were performed to determine serum magnesium, serum creatinine (CREA), blood urea nitro-gen (BUN), serum lipase (LPS), total bilirubin (TB) and glutamic-pyruvic transaminase (GPT) levels. Moreover, tissue samples of common bile duct (CBD), liver and kidney were taken for histological evaluation...
February 2014: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/23495090/zinc-exhibits-ideal-physiological-corrosion-behavior-for-bioabsorbable-stents
#11
Patrick K Bowen, Jaroslaw Drelich, Jeremy Goldman
Zinc is proposed as an exciting new biomaterial for use in bioabsorbable cardiac stents. Not only is zinc a physiologically relevant metal with behavior that promotes healthy vessels, but it combines the best behaviors of both current bioabsorbable stent materials: iron and magnesium. Shown here is a composite image of zinc degradation in a murine (rat) artery.
May 14, 2013: Advanced Materials
https://www.readbyqxmd.com/read/23407712/site-specific-gene-delivery-to-stented-arteries-using-magnetically-guided-zinc-oleate-based-nanoparticles-loaded-with-adenoviral-vectors
#12
Michael Chorny, Ilia Fishbein, Jillian E Tengood, Richard F Adamo, Ivan S Alferiev, Robert J Levy
Gene therapeutic strategies have shown promise in treating vascular disease. However, their translation into clinical use requires pharmaceutical carriers enabling effective, site-specific delivery as well as providing sustained transgene expression in blood vessels. While replication-deficient adenovirus (Ad) offers several important advantages as a vector for vascular gene therapy, its clinical applicability is limited by rapid inactivation, suboptimal transduction efficiency in vascular cells, and serious systemic adverse effects...
June 2013: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/23203562/degradable-magnesium-based-implant-materials-with-anti-inflammatory-activity
#13
Qiuming Peng, Kun Li, Zengsheng Han, Erde Wang, Zhigang Xu, Riping Liu, Yongjun Tian
The objective of this study was to prepare a new biodegradable Mg-based biomaterial, which provides good mechanical integrity in combination with anti-inflammatory function during the degradation process. The silver element was used, because it improved the mechanical properties as an effective grain refiner and it is also treated as a potential anti-inflammatory core. The new degradable Mg-Zn-Ag biomaterial was prepared by zone solidification technology and extrusion. The mechanical properties were mostly enhanced by fine grain strengthening...
July 2013: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/22927340/on-the-biodegradability-mechanical-behavior-and-cytocompatibility-of-amorphous-mg72-zn23-ca5-and-crystalline-mg70-zn23-ca5-pd2-alloys-as-temporary-implant-materials
#14
E Pellicer, S González, A Blanquer, S Suriñach, M D Baró, L Barrios, E Ibáñez, C Nogués, J Sort
The evolution of microstructure and mechanical properties of almost fully amorphous Mg(72) Zn(23) Ca(5) and crystalline Mg(70) Zn(23) Ca(5) Pd(2) alloys during immersion in Hank's balanced salt solution (HBSS), as well as their cytocompatibility, are investigated in order to assess the feasibility of both materials as biodegradable implants. Though the crystalline Mg(70) Zn(23) Ca(5) Pd(2) sample shows lower wettability and more positive corrosion potential, this sample degrades much faster upon incubation in HBSS as a consequence of the formation of micro-galvanic couples between the nobler Pd-rich dendrites and the surrounding phases...
February 2013: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/22402149/the-microstructure-and-properties-of-cyclic-extrusion-compression-treated-mg-zn-y-nd-alloy-for-vascular-stent-application
#15
Qiong Wu, Shijie Zhu, Liguo Wang, Qian Liu, Gaochao Yue, Jun Wang, Shaokang Guan
Magnesium alloys are promising candidate materials for cardiovascular stents due to their good biocompatibility and degradation properties in the human body. However, in vivo tests also show that improvement in their mechanical properties and corrosion resistance is necessary before wide application. In this study, cyclic extrusion compression (CEC) was used to enhance the mechanical properties and corrosion resistance of Mg-Zn-Y-Nd alloy. The results show that the grain size was greatly refined to 1 μm after CEC treatment...
April 2012: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/21638154/comparison-of-high-efficiency-czt-spect-mpi-to-coronary-angiography
#16
COMPARATIVE STUDY
W Lane Duvall, Joseph M Sweeny, Lori B Croft, Maya H Barghash, Nitin K Kulkarni, Krista A Guma, Milena J Henzlova
BACKGROUND: The recently introduced cadmium zinc telluride (CZT) SPECT cameras have the potential to reduce radiation exposure to patients and shorten imaging time. So far, there has been only one small study comparing the results of high efficiency CZT SPECT myocardial perfusion imaging (MPI) to invasive coronary angiography. METHODS: All patients who had either a Tc-99m sestamibi or Tl-201 SPECT MPI study using a CZT camera (GE Discovery NM 530c) over a 1-year period followed by a coronary angiogram within 2 months were included...
August 2011: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/20625691/association-of-polymorphisms-of-zinc-metalloproteinases-with-clinical-response-to-stem-cell-therapy
#17
RANDOMIZED CONTROLLED TRIAL
R Panovsky, A Vasku, J Meluzin, M Kaminek, J Mayer, S Janousek, V Kincl, L Groch, M Navratil
AIM: The purpose of this study was to assess the associations of polymorphisms in two metalloproteinase genes-metalloproteinase-2 (MMP-2) and angiotensin converting enzyme (ACE)-with clinical response to autologous transplantation of mononuclear bone marrow cells (MBMC) in patients with acute myocardial infarction. METHODS: The double centre study included 48 patients with a first acute myocardial infarction treated with primary coronary angioplasty, stent implantation and transplantation of MBMC...
August 2010: Herz
https://www.readbyqxmd.com/read/20352299/microstructure-and-corrosion-properties-of-as-sub-rapid-solidification-mg-zn-y-nd-alloy-in-dynamic-simulated-body-fluid-for-vascular-stent-application
#18
Jun Wang, Liguo Wang, Shaokang Guan, Shijie Zhu, Chenxing Ren, Shusen Hou
Magnesium alloy stent has been employed in animal and clinical experiment in recent years. It has been verified to be biocompatible and degradable due to corrosion after being implanted into blood vessel. Mg-Y-Gd-Nd alloy is usually used to construct an absorbable magnesium alloy stent. However, the corrosion resistant of as cast Mg-Y-Gd-Nd alloy is poor relatively and the control of corrosion rate is difficult. Aiming at the requirement of endovascular stent in clinic, a new biomedical Mg-Zn-Y-Nd alloy with low Zn and Y content (Zn/Y atom ratio 6) was designed, which exists quasicrystals to improve its corrosion resistance...
July 2010: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/20186738/haemo-and-cytocompatibility-of-bioresorbable-homo-and-copolymers-prepared-from-1-3-trimethylene-carbonate-lactides-and-epsilon-caprolactone
#19
Jian Yang, Feng Liu, Song Tu, Yuanwei Chen, Xianglin Luo, Zhiqian Lu, Jia Wei, Suming Li
A series of bioresorbable polymers were prepared by ring-opening polymerization of L-lactide (LLA), DL-lactide (DLLA), epsilon-caprolactone (CL) and 1,3-trimethylene carbonate (TMC), using low toxic zinc lactate as catalyst. The various PLLA, PTMC, PCL homopolymers, and PLLA-TMC, PDLLA-TMC, PCL-TMC copolymers with 50/50 molar ratios were characterized by using analytical techniques such as proton nuclear magnetic resonance, gel permeation chromatography, tensiometer, and differential scanning calorimetry. The haemo- and cyto-compatibility were investigated in order to evaluate the potential of the polymers as coating material in drug eluting stents...
August 2010: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/19815099/on-the-in-vitro-and-in-vivo-degradation-performance-and-biological-response-of-new-biodegradable-mg-y-zn-alloys
#20
Anja C Hänzi, Isabel Gerber, Michael Schinhammer, Jörg F Löffler, Peter J Uggowitzer
A design strategy deployed in developing new biodegradable Mg-Y-Zn alloys is summarized and the key factors influencing their suitability for medical applications are described. The Mg-Y-Zn alloys reveal microstructural features and mechanical characteristics expected to be appropriate for vascular intervention applications. The focus of this article lies in the evaluation of the degradation performance and biological response of the alloys with respect to their potential as implant materials (stents). The degradation characteristics analyzed by immersion testing and electrochemical impedance spectroscopy in simulated physiological media reveal slow and homogeneous degradation...
May 2010: Acta Biomaterialia
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