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https://www.readbyqxmd.com/read/28818052/proteomic-analysis-during-of-spore-germination-of-moniliophthora-perniciosa-the-causal-agent-of-witches-broom-disease-in-cacao
#1
Joise Hander Mares, Karina Peres Gramacho, Everton Cruz Santos, André da Silva Santiago, Juliano Oliveira Santana, Aurizângela Oliveira de Sousa, Fátima Cerqueira Alvim, Carlos Priminho Pirovani
BACKGROUND: Moniliophthora perniciosa is a phytopathogenic fungus responsible for witches' broom disease of cacao trees (Theobroma cacao L.). Understanding the molecular events during germination of the pathogen may enable the development of strategies for disease control in these economically important plants. In this study, we determined a comparative proteomic profile of M. perniciosa basidiospores during germination by two-dimensional SDS-PAGE and mass spectrometry. RESULTS: A total of 316 proteins were identified...
August 17, 2017: BMC Microbiology
https://www.readbyqxmd.com/read/28807099/role-of-endoplasmic-reticulum-stress-in-silica-induced-apoptosis-in-raw264-7-cells
#2
Yong Bin Hu, Xia Wu, Xiao Feng Qin, Lei Wang, Pin Hua Pan
OBJECTIVE: We investigated the role of endoplasmic reticulum stress (ERS) in silica-induced apoptosis in alveolar macrophages in vitro. METHODS: RAW264.7 cells were incubated with 200 μg/mL silica for different time periods. Cell viability was assayed by the MTT assay. Cell apoptosis was evaluated by DAPI staining, flow cytometry analysis, and Western blot analysis of caspase-3. Morphological changes in the endoplasmic reticulum were observed by transmission electron microscopy...
August 2017: Biomedical and Environmental Sciences: BES
https://www.readbyqxmd.com/read/28802884/astrocytes-and-endoplasmic-reticulum-stress-a-bridge-between-obesity-and-neurodegenerative-diseases
#3
REVIEW
Cynthia A Martin-Jiménez, Ángela García-Vega, Ricardo Cabezas, Gjumrakch Aliev, Valentina Echeverria, Janneth González, George E Barreto
Endoplasmic reticulum (ER) is a subcellular organelle involved in protein folding and processing. ER stress constitutes a cellular process characterized by accumulation of misfolded proteins, impaired lipid metabolism and induction of inflammatory responses. ER stress has been suggested to be involved in several human pathologies, including neurodegenerative diseases and obesity. Different studies have shown that both neurodegenerative diseases and obesity trigger similar cellular responses to ER stress. Moreover, both diseases are assessed in astrocytes as evidences suggest these cells as key regulators of brain homeostasis...
August 9, 2017: Progress in Neurobiology
https://www.readbyqxmd.com/read/28801170/pgc-1%C3%AE-in-aging-and-lifelong-exercise-training-mediated-regulation-of-upr-in-mouse-liver
#4
Caroline M Kristensen, Christina T Brandt, Stine Ringholm, Henriette Pilegaard
Aging is associated with changes in several metabolic pathways affecting liver function including the adaptive unfolded protein response (UPR). On the other hand, exercise training has been shown to exert beneficial effects on metabolism including the liver and exercise training has been reported to affect hepatic UPR. PGC-1α is a transcriptional coactivator involved in exercise training-induced adaptations in skeletal muscle and liver. Therefore, the aim of the present study was to examine the impact of PGC-1α in aging and lifelong exercise training-induced hepatic UPR in mice...
August 8, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28797762/ceramide-enhances-cox-2-expression-and-vsmc-contractile-hyperreactivity-via-er-stress-signal-activation
#5
Huina Zhang, Juanfen Li, Linghai Li, Pingsheng Liu, Yongxiang Wei, Zongjie Qian
Ceramide accumulation in blood vessels has been attributed to vascular dysfunction in progressive vascular complications in metabolic diseases. The present study showed that ceramide pretreatment promoted PE-induced vasoconstriction in rat endothelium-denuded vascular rings in a time- and dose-dependent manner. Endoplasmic reticulum (ER) stress inhibitors, 4-PBA and TUDCA, COX-2 inhibitors, Celecoxib and NS398, as well as PGE2 receptor antagonist AH-6809 attenuated ceramide-promoted vascular hyperreactivity...
August 7, 2017: Vascular Pharmacology
https://www.readbyqxmd.com/read/28782832/aav-delivery-of-grp78-bip-promotes-adaptation-of-human-rpe-cell-to-er-stress
#6
Shima Ghaderi, Shahin Ahmadian, Zahra-Soheila Soheili, Hamid Ahmadieh, Shahram Samiei, Samira Kheitan, Ehsan Ranaei Pirmardan
Adeno associated virus (AAV)-mediated gene delivery of GRP78 (78kDa glucose-regulated protein) attenuates the condition of endoplasmic reticulum (ER) stress and prevents apoptotic loss of photoreceptors in retinitis pigmentosa (RP) rats. In the current study we overexpressed Grp78 with the help of AAV-2 in primary human retinal pigmented epithelium (hRPE) cell cultures and examined its effect on cell response to ER stress. The purpose of this work was studying potential stimulating effect of GRP78 on adaptation/pro-survival of hRPE cells under ER stress, as an in vitro model for RPE degeneration...
August 7, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28769758/the-role-of-bip-retrieval-by-the-kdel-receptor-in-the-early-secretory-pathway-and-its-effect-on-protein-quality-control-and-neurodegeneration
#7
REVIEW
Hisayo Jin, Mari Komita, Tomohiko Aoe
Protein quality control in the early secretory pathway is a ubiquitous eukaryotic mechanism for adaptation to endoplasmic reticulum (ER) stress. An ER molecular chaperone, immunoglobulin heavy chain-binding protein (BiP), is one of the essential components in this process. BiP interacts with nascent proteins to facilitate their folding. BiP also plays an important role in preventing aggregation of misfolded proteins and regulating the ER stress response when cells suffer various injuries. BiP is a member of the 70-kDa heat shock protein (HSP70) family of molecular chaperones that resides in the ER...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28767194/echinacoside-s-nigrostriatal-dopaminergic-protection-against-6-ohda-induced-endoplasmic-reticulum-stress-through-reducing-the-accumulation-of-seipin
#8
Yajie Zhang, Hongyan Long, Fuqiong Zhou, Weina Zhu, Jie Ruan, Yang Zhao, Yan Lu
Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Recent epidemiological studies suggest that echinacoside (ECH), a phenylethanoid glycoside found in Cistanche deserticola, has a protective effect against the development of PD. However, the detailed mechanisms of how ECH suppresses neuronal death have not been fully elucidated. In this study, we confirmed that ECH protects nigrostriatal neurons against 6-hydroxydopamine (6-OHDA)-induced endoplasmic reticulum stress (ERS) in vivo and in vitro...
August 2, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28764439/comparing-malleability-of-phonetic-category-between-i-and-u
#9
Reiko Kataoka, Hahn Koo
This study reports differential category retuning effect between [i] and [u]. Two groups of American listeners were exposed to ambiguous vowels ([i/u]) within words that index a phoneme /i/ (e.g., athl[i/u]t) (i-group) or /u/ (e.g., aftern[i/u]n) (u-group). Before and after the exposure these listeners categorized sounds from a [bip]-[bup] continuum. The i-group significantly increased /bip/ responses after exposure, but the u-group did not change their responses significantly. These results suggest that the way mental representation handles phonetic variation may influence malleability of each category, highlighting the complex relationship among distribution of sounds, their mental representation, and speech perception...
July 2017: Journal of the Acoustical Society of America
https://www.readbyqxmd.com/read/28748915/the-endoplasmic-reticulum-stress-autophagy-pathway-is-involved-in-apelin-13-induced-cardiomyocyte-hypertrophy-in-vitro
#10
Feng Xie, Di Wu, Shi-Fang Huang, Jian-Gang Cao, He-Ning Li, Lu He, Mei-Qing Liu, Lan-Fang Li, Lin-Xi Chen
Apelin is the endogenous ligand for the G protein-coupled receptor APJ, and plays important roles in the cardiovascular system. Our previous studies showed that apelin-13 promotes the hypertrophy of H9c2 rat cardiomyocytes through the PI3K-autophagy pathway. The aim of this study was to explore what roles ER stress and autophagy played in apelin-13-induced hypertrophy of cardiomyocytes in vitro. Treatment of H9c2 cells with apelin-13 (0.001-2 μmol/L) dose-dependently increased the production of ROS and the expression levels of NADPH oxidase 4 (NOX4)...
July 27, 2017: Acta Pharmacologica Sinica
https://www.readbyqxmd.com/read/28731173/anacardic-acid-induces-cell-apoptosis-of-prostatic-cancer-through-autophagy-by-er-stress-dapk3-akt-signaling-pathway
#11
Jing Tan, Xianzhen Jiang, Guangming Yin, Leye He, Jianye Liu, Zhi Long, Zhiqiang Jiang, Kun Yao
Anacardic acid, which is commonly seen in plants of Anacardiaceae, is an important composition of cashew, ginkgo leaf and fruit, and it has been suggested in previous research to show antitumor activity. The main aim of the present study was to evaluate the anticancer effects of anacardic acid on cell apoptosis of prostatic cancer and molecular mechanisms of this phenomenon. In this study we found that anacardic acid inhibited cell proliferation, induced apoptosis and caspase-3/9 activities and Bax protein expression of prostatic cancer...
July 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28728847/a-novel-role-for-bone-derived-cells-in-ankylosing-spondylitis-focus-on-il-23
#12
Sungsin Jo, Bon San Koo, Bitnara Lee, Eunji Kwon, Young Lim Lee, Heekyoung Chung, Il-Hoon Sung, Ye-Soo Park, Tae-Hwan Kim
The main aim of this study are to explore the role of bone-derived cells (BdCs) in ankylosing spondylitis (AS) and determine the underlying molecular mechanisms of IL-23 production. Primary BdCs were isolated from diced bone of facet joints obtained during surgery from seven AS patients and seven disease control (Ct) patients. Osteoblastic activity of BdCs was assessed by measuring their alkaline phosphatase activity and by alizarin red staining. Osteoblast and endoplasmic reticulum (ER) stress-related genes were assessed by quantitative PCR, immunoblotting, immunofluorescence, and immunohistochemistry...
July 17, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28706146/ros-independent-nrf2-activation-in-prostate-cancer
#13
Ilaria Bellezza, Paolo Scarpelli, Salvatore V Pizzo, Silvia Grottelli, Egidia Costanzi, Alba Minelli
In prostate cancer, oxidative stress and the subsequent Nrf2 activation promote the survival of cancer cells and acquired chemoresistance. Nrf2 links prostate cancer to endoplasmic reticulum stress, an event that triggers the unfolded protein response, aiming to restore cellular homeostasis as well as an adaptive survival mechanism. Glucose-regulated protein of 78 kD /immunoglobulin heavy chain binding protein (GRP78/BiP) is a key molecular chaperone in the endoplasmic reticulum that, when expressed at the cell surface, acts as a receptor for several signaling pathways enhancing antiapoptotic and proliferative signals...
June 28, 2017: Oncotarget
https://www.readbyqxmd.com/read/28703940/ebselen-impairs-cellular-oxidative-state-and-induces-endoplasmic-reticulum-stress-and-activation-of-crucial-mitogen-activated-protein-kinases-in-pancreatic-tumour-ar42j-cells
#14
Patricia Santofimia-Castaño, Alicia Izquierdo-Alvarez, María Plaza-Davila, Antonio Martinez-Ruiz, Miguel Fernandez-Bermejo, Jose M Mateos-Rodriguez, Gines M Salido, Antonio Gonzalez
Ebselen (2-phenyl-1,2-benzisoselenazol-3(2H)-one) is an organoselenium radical scavenger compound, which has strong antioxidant and anti-inflammatory effects. However, evidence suggests that this compound could exert deleterious actions on cell physiology. In this study we have analyzed the effect of ebselen on rat pancreatic AR42J cells. Cytosolic free-Ca2(+) concentration ([Ca(2+) ]c ), cellular oxidative status, setting of endoplasmic reticulum stress and phosphorylation of major mitogen-activated protein kinases were analyzed...
July 13, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/28702041/characterization-of-bip-genes-from-pepper-capsicum-annuum-l-and-the-role-of-cabip1-in-response-to-endoplasmic-reticulum-and-multiple-abiotic-stresses
#15
Hu Wang, Huanhuan Niu, Yufei Zhai, Minghui Lu
Adverse environmental conditions have a detrimental impact on crop growth and development, and cause protein denaturation or misfolding. The binding protein (BiP) plays an important protective role by alleviating endoplasmic reticulum (ER) stress induced by misfolded proteins. In this study, we characterized three BiP genes (CaBiP1, CaBiP2, and CaBiP3) in pepper, an economically important vegetable and spice species. The role of CaBiP1 in plant tolerance to ER stress and adverse environmental conditions (including heat, salinity, osmotic and drought stress) were investigated...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28687316/levodopa-l-dopa-attenuates-endoplasmic-reticulum-stress-response-and-cell-death-signaling-through-drd2-in-sh-sy5y-neuronal-cells-under-%C3%AE-synuclein-induced-toxicity
#16
Juhyun Song, Byeong C Kim, Dai-Trang T Nguyen, Manikandan Samidurai, Seong-Min Choi
Parkinson's disease (PD) is characterized by the formation of Lewy bodies (LBs) in dopaminergic neurons. α-Synuclein (α-syn), a major protein component of LBs, is known to regulate synaptic plasticity, with a crucial role in memory and motor function in the central nervous system. Levodopa (L-3,4-dihydroxyphenylalanine; also known as L-DOPA) is considered the most effective medication for controlling the symptoms of PD. However, it is unclear whether L-DOPA improves the neuropathology of PD. In the present study, we investigated the effect of L-DOPA on SH-SY5Y neuronal cells under α-syn-induced toxicity...
July 4, 2017: Neuroscience
https://www.readbyqxmd.com/read/28684299/cyperus-amuricus-induces-g1-arrest-and-apoptosis-through-endoplasmic-reticulum-stress-and-mitochondrial-signaling-in-human-hepatocellular-carcinoma-hep3b-cells
#17
Hai Ha Thi Pham, Yeong-Ae Seong, Daniel Ngabire, Chul-Woong Oh, Gun-Do Kim
ETHNOPHARMACOLOGY RELEVANCE: Cyperus amuricus (C. amuricus), belongs to the family Cyperaceae, was used to exert wound healing, diuretic, astringent and other intestinal problems in oriental medicine. However, only a few studies have reported its anticancer activities. AIM OF THE STUDY: In this study, we determined the activity of C. amuricus on ER stress-induced cell death and G1 cell cycle arrest in human hepatocellular carcinoma (HCC) Hep3B cells. MATERIALS AND METHODS: The in vitro cell proliferation assay of C...
July 4, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28679068/berberine-hydrochloride-counteracts-enhanced-il-8-expression-induced-by-sn-38-in-ags-cells
#18
Jin Chen, De-Ning Ma, Yuan Fang, Ning Zhang, Jia-Min Zhou, Xiao-Lan Yin, Feng Liu, Zong-Tao Chai
IL-8 over-expression could enhance cancer metastasis. In present study, berberine hydrochloride (BER) triggered proliferative inhibition and G2/M arrest in AGS cells, down-regulated protein expression of cyclin B1, Bcl-2, up-regulated expression of p21, p53 and cleaved caspase 3, but showed no effect on protein expression of CHOP, Bip, and caspase 4. BER could down-regulate the enhanced IL-8 expression through down-regulating ERK1/2 and p38 MAPK over-activation induced by SN 38. The increased IL-8 mediated adhesive ability of AGS cells to HUVECs induced by SN 38, could be reduced by BER...
July 5, 2017: Journal of Asian Natural Products Research
https://www.readbyqxmd.com/read/28678786/bidirectional-interplay-of-hsf1-degradation-and-upr-activation-promotes-tau-hyperphosphorylation
#19
Eunhee Kim, Kazuko Sakata, Francesca-Fang Liao
The unfolded protein response (UPR) in the endoplasmic reticulum (ER) and the cytoplasmic heat stress response are two major stress response systems necessary for maintaining proteostasis for cellular health. Failure of either of these systems, such as in sustained UPR activation or in insufficient heat shock response activation, can lead to the development of neurodegeneration. Alleviation of ER stress and enhancement of heat shock response through heat shock factor 1 (HSF1) activation have previously been considered as attractive potential therapeutic targets for Alzheimer's disease (AD)-a prevalent and devastating tauopathy...
July 2017: PLoS Genetics
https://www.readbyqxmd.com/read/28656015/bip-master-regulator-of-the-unfolded-protein-response-and-crucial-factor-in-flavivirus-biology%C3%A2
#20
REVIEW
Tyler G Lewy, Jeffrey M Grabowski, Marshall E Bloom
Flaviviruses have an intimate relationship with their host cells, utilizing host proteins during replication. Much of viral genome replication and virion assembly occurs on and within the endoplasmic reticulum (ER). As a cellular protein folding hub, the ER provides an ideal environment for flaviviruses to replicate. Flaviviruses can interact with several ER processes, including the unfolded protein response (UPR), a cellular stress mechanism responsible for managing unfolded protein accumulation and ER stress...
June 2017: Yale Journal of Biology and Medicine
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