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https://www.readbyqxmd.com/read/29666155/sil1-the-er-hsp70-co-chaperone-plays-a-critical-role-in-maintaining-skeletal-muscle-proteostasis-and-physiology
#1
Viraj P Ichhaporia, Jieun Kim, Kanisha Kavdia, Peter Vogel, Linda Horner, Sharon Frase, Linda M Hendershot
Mutations in SIL1 , a co-factor for the endoplasmic reticular (ER) chaperone BiP, cause Marinesco-Sjögren syndrome (MSS), an autosomal recessive disorder. Using a mouse model, we characterized molecular aspects of the progressive myopathy associated with MSS. Proteomic-profiling of quadriceps at the onset of myopathy revealed that SIL1 deficiency affected multiple pathways critical to muscle physiology. We observed an increase in ER chaperones prior to the onset of muscle weakness, which was complemented by up-regulation of multiple components of cellular protein degradation pathways...
April 9, 2018: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/29655325/an-atomic-mean-field-spin-orbit-approach-within-exact-two-component-theory-for-a-non-perturbative-treatment-of-spin-orbit-coupling
#2
Junzi Liu, Lan Cheng
An atomic mean-field (AMF) spin-orbit (SO) approach within exact two-component theory (X2C) is reported, thereby exploiting the exact decoupling scheme of X2C, the one-electron approximation for the scalar-relativistic contributions, the mean-field approximation for the treatment of the two-electron SO contribution, and the local nature of the SO interactions. The Hamiltonian of the proposed SOX2CAMF scheme comprises the one-electron X2C Hamiltonian, the instantaneous two-electron Coulomb interaction, and an AMF SO term derived from spherically averaged Dirac-Coulomb Hartree-Fock calculations of atoms; no molecular relativistic two-electron integrals are required...
April 14, 2018: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29653387/bovine-uterus-derived-exosomes-improve-developmental-competence-of-somatic-cell-nuclear-transfer-embryos
#3
Fang Qiao, Hui Ge, Xiaonan Ma, Ying Zhang, Zhenzi Zuo, Mengyun Wang, Yong Zhang, Yongsheng Wang
Exosomes widely exist in various tissues and body fluids, including blood, tissue fluid, and urine. In the present study, exosomes were first isolated from the early luteal phase uterus and confirmed through morphological examination, immunofluorescence (IF) staining of special membrane antigen, and Western blot. The effects of exosomes on the developmental competence of somatic cell nuclear transfer (SCNT) embryos were investigated. Transmission electron microscopy results showed that the isolated exsomes were spherical particles with a 50 nm-150 nm diameter...
March 22, 2018: Theriogenology
https://www.readbyqxmd.com/read/29651609/the-delta-opioid-peptide-dadle-represses-hypoxia-reperfusion-mimicked-stress-mediated-apoptotic-cell-death-in-human-mesenchymal-stem-cells-in-part-by-downregulating-the-unfolded-protein-response-and-ros-along-with-enhanced-anti-inflammatory-effect
#4
Madhubanti Mullick, Dwaipayan Sen
Hypoxia-reperfusion (H/R) emblems a plethora of pathological conditions which is potent in contributing to the adversities encountered by human mesenchymal stem cells (hMSCs) in post-transplant microenvironment, resulting in transplant failure. D-Alanine 2, Leucine 5 Enkephaline (DADLE)-mediated delta opioid receptor (DOR) activation is well-known for its recuperative properties in different cell types like neuronal and cardiomyocytes. In the current study its effectiveness in assuaging hMSC mortality under H/R-like insult has been delineated...
April 12, 2018: Stem Cell Reviews
https://www.readbyqxmd.com/read/29651333/a-novel-organ-preservation-solution-with-efficient-clearance-of-red-blood-cells-improves-kidney-transplantation-in-a-canine-model
#5
Sheng Wang, Kristyn Gumpper, Tao Tan, Xianzhang Luo, Hui Guo, Changsheng Ming, Hanying Jiang, Jiangguo Fang, Guang Du, Hua Zhu, Jianjie Ma, Zhishui Chen, Nianqiao Gong
Organ preservation solutions are designed to minimize organ damage during transplantation. A novel preservation solution, WMO-II, was developed to have a low viscosity and to improve microvasculature perfusion for kidneys. In an autologous canine transplantation model, kidney function and recovery were evaluated after organs were flushed and cold-stored with WMO-II or HTK solution, a perfusate currently approved for clinical use. The average number of red blood cells remaining in a single glomerulus after flushing with WMO-II was significantly reduced when compared with HTK solution...
2018: Cell & Bioscience
https://www.readbyqxmd.com/read/29650257/neuropeptide-y-mitigates-er-stress-induced-neuronal-cell-death-by-activating-the-pi3k-xbp1-pathway
#6
Do Yeon Lee, Seung Hyun Hong, Bokyung Kim, Dong-Seok Lee, Kweon Yu, Kyu-Sun Lee
The unfolded protein response (UPR) is an evolutionarily conserved adaptive reaction that increases cell survival under endoplasmic reticulum (ER) stress conditions. ER stress-associated neuronal cell death pathways play roles in the pathogenesis of neurodegenerative diseases, including Alzheimer's, Parkinson's, and Huntington's disease. Neuropeptide Y (NPY) has an important role in neuroprotection against neurodegenerative diseases. In this study, we investigated whether NPY has a protective role in ER stress-induced neuronal cell death in SK-N-SH human neuroblastoma cells...
April 6, 2018: European Journal of Cell Biology
https://www.readbyqxmd.com/read/29648853/individualized-motivational-plans-in-batterer-intervention-programs-a-randomized-clinical-trial
#7
Marisol Lila, Enrique Gracia, Alba Catalá-Miñana
OBJECTIVE: Treatment compliance and motivation to change are among the main challenges to improving batterer intervention program (BIP) effectiveness. This study examined whether adding an individualized motivational plan (IMP) to a standard BIP (SBIP) increased intervention effectiveness relative to BIP alone. METHOD: One hundred sixty males convicted of intimate partner violence were randomly assigned to receive 70 hr of either SBIP or SBIP plus IMP. The IMP is based on motivational interviewing, stages of change, and strength-based theory principles...
April 2018: Journal of Consulting and Clinical Psychology
https://www.readbyqxmd.com/read/29623310/identification-of-pp1-gadd34-substrates-involved-in-the-unfolded-protein-response-using-k-bips-a-method-for-phosphatase-substrate-identification
#8
Pavithra M Dedigama-Arachchige, Nuwan P N Acharige, Mary Kay H Pflum
Phosphorylation is a key post-translational modification in cell signaling, which is regulated by the equilibrium activities of kinases and phosphatases. The biological significance of many phosphorylation events remains poorly characterized due to the scarcity of tools to discover phosphatases substrates. In prior work, we established kinase-catalyzed biotinylation where kinases accept the γ-modified ATP analog, ATP-biotin, to label phosphoproteins. Here, we developed a novel method to study substrates of phosphatases using kinase-catalyzed biotinylation termed K-BIPS (Kinase-catalyzed Biotinylation to Identify Phosphatase Substrates)...
April 6, 2018: Molecular omics
https://www.readbyqxmd.com/read/29617857/fic-proteins-from-bacteria-to-humans-and-back-again
#9
Simon Veyron, Gérald Peyroche, Jacqueline Cherfils
During the last decade, FIC proteins have emerged as a large family comprised of a variety of bacterial enzymes and a single member in animals. The air de famille of FIC proteins stems from a domain of conserved structure, which catalyzes the post-translational modification of proteins (PTM) by a phosphate-containing compound. In bacteria, examples of FIC proteins include the toxin component of toxin/antitoxin modules, such as Doc-Phd and VbhT-VbhA, toxins secreted by pathogenic bacteria to divert host cell processes, such as VopS, IbpA and AnkX, and a vast majority of proteins of unknown functions...
March 1, 2018: Pathogens and Disease
https://www.readbyqxmd.com/read/29617697/proteomic-profiling-of-diffuse-large-b-cell-lymphomas
#10
Anna Kwiecińska, Anna Porwit, Nazariy Souchelnytskyi, Ann Kaufeldt, Catharina Larsson, Svetlana Bajalica-Lagercrantz, Serhiy Souchelnytskyi
OBJECTIVE: The aim of this study was to identify differences in proteome profiles of diffuse large B-cell lymphoma (DLBCL) of nongerminal center (non-GC) versus GC type in the search for new markers and drug targets. METHODS: Six DLBCL, with 3 repeats for each, were used for the initial study by proteomics: 3 non-GC and 3 GC DLBCL cases. For immunohistochemistry, tissue microarrays were made from 31 DLBCL samples: 16 non-GC de novo lymphomas and 15 GC cases (11 transformed from follicular lymphomas and 4 de novo GC lymphomas)...
April 4, 2018: Pathobiology: Journal of Immunopathology, Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29616874/porphyromonas-gingivalis-traffics-into-endoplasmic-reticulum-rich-autophagosomes-for-successful-survival-in-human-gingival-epithelial-cells
#11
Kyulim Lee, JoAnn S Roberts, Chul Hee Choi, Kalina R Atanasova, Özlem Yilmaz
Porphyromonas gingivalis, an opportunistic pathogen usurps gingival epithelial cells (GECs) as primary intracellular niche for its colonization in the oral mucosa. However, the precise characterization of the intracellular trafficking and fate of P. gingivalis in GECs remains incomplete. Therefore, we employed high-resolution three-dimensional-transmission-electron-microscopy to determine the subcellular location of P. gingivalis in human primary GECs upon invasion. Serial sections of infected-GECs and their tomographic reconstruction depicted ER-rich-double-membrane autophagosomal-vacuoles harboring P...
April 4, 2018: Virulence
https://www.readbyqxmd.com/read/29607540/melatonin-improves-insulin-resistance-and-hepatic-steatosis-through-attenuation-of-alpha-2-hs-glycoprotein
#12
Jee-In Heo, Dae Wui Yoon, Ji Hee Yu, Nam Hoon Kim, Hye Jin Yoo, Ji A Seo, Sin Gon Kim, Kyung Mook Choi, Sei Hyun Baik, Dong Seop Choi, Nan Hee Kim
Melatonin plays an important role in regulating circadian rhythms. It also acts as a potent anti-oxidant and regulates glucose and lipid metabolism, although the exact action mechanism is not clear. The α2-HS-glycoprotein gene (AHSG) and its protein, fetuin-A (FETUA) is one of the hepatokines and is known to be associated with insulin resistance and type 2 diabetes. The aim of this study was to determine whether melatonin improves hepatic insulin resistance and hepatic steatosis in a FETUA-dependent manner...
April 1, 2018: Journal of Pineal Research
https://www.readbyqxmd.com/read/29600167/protective-effects-of-a-composition-of-chinese-herbs-gurigumu-13-on-retinal-ganglion-cell-apoptosis-in-dba-2j-glaucoma-mouse-model
#13
Qiu-Li Zhang, Wei Wang, Yan Jiang, Tian-Zi Zhang, Zhan-Jun Lu, Ao Jiang
AIM: To explore the concrete mechanism of a Mongolian compound medicine-Gurigumu-13 (GRGM) for glaucoma treatment. METHODS: DBA/2J mice, as glaucoma models, were intragastric administrated with GRGM to study the effect of GRGM on retinal ganglion cells (RGCs). The loss of RGCs was evaluated with the number of RGCs and axons. The expression of the target protein of RGCs or mouse retinas was determined by Western blot. The relative content of malondialdehyde (MDA) was examined by ELISA assay...
2018: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/29596872/caveolin-1-deficiency-protects-pancreatic-%C3%AE-cells-against-palmitate-induced-dysfunction-and-apoptosis
#14
Wen Zeng, Jiansong Tang, Haicheng Li, Haixia Xu, Hongyun Lu, Hangya Peng, Chuwen Lin, Rili Gao, Shuo Lin, Keyi Lin, Kunying Liu, Yan Jiang, Jianping Weng, Longyi Zeng
Lipotoxicity leads to insulin secretion deficiency, which is among the important causes for the onset of type 2 diabetes mellitus. Thus, the restoration of β-cell mass and preservation of its endocrine function are long-sought goals in diabetes research. Previous studies have suggested that the membrane protein caveolin-1 (Cav-1) is implicated in β-cell apoptosis and insulin secretion, however, the underlying mechanisms still remains unclear. Our objective is to explore whether Cav-1 depletion protects pancreatic β cells from lipotoxicity and what are the underlying mechanisms...
March 26, 2018: Cellular Signalling
https://www.readbyqxmd.com/read/29595074/alleviation-of-hippocampal-endoplasmic-reticulum-stress-by-allomyrina-dichotoma-larvae-extract
#15
Jongwan Kim, Md Nazmul Haque, Tae-Won Goo, Il Soo Moon
In the brain, endoplasmic reticulum (ER) stress results in synaptic dysfunction and eventually leads to neurodegeneration. Allomyrina dichotoma larvae are a Chinese ethnomedicine and are widely used in East Asia. In the present study, we investigated the ability of ethanol extract of A. dichotoma larvae (ADE) to improve synaptic structure and function by activating unfolded protein response (UPR) under ER stress in animal and neuron culture models. ER stress was induced in obese mice fed a high fat diet (HFD) or by treating dissociated cultures of rat embryonic (E19) hippocampal neurons with tunicamycin (TM)...
March 29, 2018: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/29581037/the-association-of-body-mass-index-and-20-year-all-cause-mortality-among-patients-with-stable-coronary-artery-disease
#16
Anan Younis, Arwa Younis, Ronen Goldkorn, Ilan Goldenberg, Yael Peled, Boaz Tzur, Robert Klempfner
BACKGROUND: Limited data exist regarding the long-term association of body mass index (BMI) and all-cause mortality among patients with stable coronary artery disease (CAD). Accordingly, the aim of this study is to explore the association between BMI and long-term all-cause mortality among patients with stable CAD. METHODS: Our study included 15,357 patients with stable CAD who were enrolled in the Bezafibrate Infarction Prevention (BIP) registry between February, 1990 and October1992, and subsequently followed-up through December 2014...
March 3, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29569832/bone-marrow-derived-mesenchymal-stem-cells-protect-islet-grafts-against-endoplasmic-reticulum-stress-induced-apoptosis-during-the-early-stage-after-transplantation
#17
Ying He, Dongmei Zhang, Yi Zeng, Junlei Ma, Jing Wang, Hui Guo, Ji Zhang, Mengqin Wang, Weijie Zhang, Nianqiao Gong
Early loss of grafted islets is the main obstacle to achieve favorable outcomes of islet transplantation. Mesenchymal stem cells are known to have a protective effect; however, its mechanism remains unclear. We hypothesized that bone marrow-derived mesenchymal stem cells (BMSCs) can protect grafted islets against endoplasmic reticulum stress (ERS)-induced apoptosis. In syngeneic streptozocin-induced diabetic BALB/c mice, islet grafts decreased blood glucose levels; however, the effect was not fully functional from the immediate post-transplant phase...
March 23, 2018: Stem Cells
https://www.readbyqxmd.com/read/29563863/mitofusin-dependent-er-stress-triggers-glial-dysfunction-and-nervous-system-degeneration-in-a-drosophila-model-of-friedreich-s-ataxia
#18
Oliver Edenharter, Stephan Schneuwly, Juan A Navarro
Friedreich's ataxia (FRDA) is the most important recessive ataxia in the Caucasian population. It is caused by a deficit of the mitochondrial protein frataxin. Despite its pivotal effect on biosynthesis of iron-sulfur clusters and mitochondrial energy production, little is known about the influence of frataxin depletion on homeostasis of the cellular mitochondrial network. We have carried out a forward genetic screen to analyze genetic interactions between genes controlling mitochondrial homeostasis and Drosophila frataxin...
2018: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/29563563/the-transcriptional-profiles-and-functional-implications-of-long-non-coding-rnas-in-the-unfolded-protein-response
#19
Hongyang Quan, Qianqian Fan, Chuang Li, Yan-Ying Wang, Lin Wang
The unfolded protein response (UPR) is activated, when the folding capacity is compromised in the endoplasmic reticulum (ER). To date, most studies focused on the coding genes and microRNAs in UPR. Other non-coding RNAs affected by UPR and their roles in UPR have not been systematically studied. Long noncoding RNAs (lncRNAs) are increasingly recognized as powerful epigenetic regulators. In this study, we transcriptomically profiled the lncRNAs and mRNAs from mouse embryonic fibroblasts under ER stress, and identified many differentially expressed lncRNAs and mRNAs...
March 21, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29559889/endoplasmic-reticulum-stress-in-spinal-cord-contributes-to-the-development-of-morphine-tolerance
#20
Daiqiang Liu, Yaqun Zhou, Yawen Peng, Peng Su, Zheng Li, Qiaoqiao Xu, Ye Tu, Xuebi Tian, Hui Yang, Zhen Wu, Wei Mei, Feng Gao
Morphine tolerance remains an intractable problem, which hinders its prolonged use in clinical practice. Endoplasmic reticulum (ER) stress has been proved to play a fundamental role in the pathogenesis of Alzheimer's disease, diabetes, atherosclerosis, cancer, etc. In this study, we provide the first direct evidence that ER stress may be a significant driver of morphine tolerance. Binding immunoglobulin protein (BiP), the ER stress marker, was significantly upregulated in neurons in spinal dorsal horn in rats being treated with morphine for 7 days...
2018: Frontiers in Molecular Neuroscience
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