keyword
https://read.qxmd.com/read/38472715/oxidative-stress-endoplasmic-reticulum-stress-and-apoptosis-in-the-pathology-of-alzheimer-s-disease
#21
REVIEW
Bidemi Emmanuel Ekundayo, Tajudeen Olabisi Obafemi, Olusola Bolaji Adewale, Blessing Ariyo Obafemi, Babatunji Emmanuel Oyinloye, Stella Kemilola Ekundayo
Alzheimer's disease (AD) accounts for a major statistic among the class of neurodegenerative diseases. A number of mechanisms have been identified in its pathogenesis and progression which include the amyloid beta (Aβ) aggregation, hyperphosphorylation of tau protein, oxidative stress, endoplasmic reticulum (ER) stress and apoptosis. These processes are interconnected and contribute significantly to the loss of neurons, brain mass and consequential memory loss and other cognitive difficulties. Oxidative stress in AD appears to be caused by excess of oxygen free radicals and extracellular Aβ deposits that cause local inflammatory processes and activate microglia, another possible source of reactive oxygen species (ROS)...
March 12, 2024: Cell Biochemistry and Biophysics
https://read.qxmd.com/read/38470551/association-between-blood-lead-levels-and-unfavorable-ivf-outcomes-potential-involvement-of-endoplasmic-reticulum-stress-response-in-granulosa-cells
#22
JOURNAL ARTICLE
Dan Shan, Yanning Lv, Junzhao Zhao, Fan Zhang, Haitao Xi, Haifan Qiu, Jieqiang Lv, Haolin Chen
PURPOSE: To investigate the relationship between blood lead levels (BLLs) and IVF clinical outcomes in infertile females and to further explore the possible involvement of granulosa cell (GC) endoplasmic reticulum (ER) stress in the process. METHODS: One hundred twenty-three infertile women undergoing IVF cycles were included in the current study. All participants were divided into three (low, medium, and high) groups determined by BLL tertiles. Gonadotropin releasing hormone (GnRH) agonist regimen for ovarian stimulation was used for all patients, with follicular fluids being collected on the day of oocyte retrieval...
March 12, 2024: Journal of Assisted Reproduction and Genetics
https://read.qxmd.com/read/38467911/forsythoside-a-protects-against-zearalenone-induced-cell-damage-in-chicken-embryonic-fibroblasts-via-mitigation-of-endoplasmic-reticulum-stress
#23
JOURNAL ARTICLE
Hui Hu, Qiang Yu, Yu Zheng, Hongjie Cui, Xiaohong Huang, Kaizhao Zhang
Zearalenone (ZEA) is a non-steroidal estrogenic mycotoxin that exerts its toxic effects through various damage mechanisms such as oxidative stress, endoplasmic reticulum stress (ERS), mitochondrial damage, cell cycle arrest, and apoptosis. At present, there are few studies on drugs that can rescue ZEA-induced chicken embryonic fibroblasts damage. Forsythoside A (FA) is one of effective ingredients of traditional Chinese medicine that plays a role in various biological functions, but its antitoxin research has not been investigated so far...
March 12, 2024: Veterinary Research Communications
https://read.qxmd.com/read/38467208/enhancing-precision-medicine-bispecific-antibody-mediated-targeted-delivery-of-lipid-nanoparticles-for-potential-cancer-therapy
#24
JOURNAL ARTICLE
Yue Zhang, Xiaoyan Gu, Lili Huang, Yani Yang, Jun He
The precise delivery of therapeutic agents to specific cell populations, including cancer cells, remains a target in modern medicine, to enhance treatment efficacy, while minimizing unintended side effects. This study presents a strategy utilizing bispecific antibodies for the targeted delivery of nucleic acid drugs to the surface of glucose-regulated protein 78 (GRP78)-overexpressing cancer cells. Strong binding affinity of the bispecific antibodies to GRP78-overexpressing cancer cells, including HEPG2 cells, confirmed the tumor-targeting potential of this platform...
March 9, 2024: International Journal of Pharmaceutics
https://read.qxmd.com/read/38467086/discovery-of-novel-peptide-dehydroepiandrosterone-hybrids-inducing-endoplasmic-reticulum-stress-with-effective-in-vitro-and-in-vivo-anti-melanoma-activities
#25
JOURNAL ARTICLE
Juan Feng, Yidong Liu, Xia Tian, Chen Shen, Zhiqiang Feng, Jingxu Zhang, Xiangli Yao, Meilin Pu, Xuguang Miao, Lan Ma, Shouxin Liu
Steroid hybrids have emerged as a type of advantageous compound as they could offer improved pharmacological and pharmaceutical properties. Here, we report a series of novel peptide-dehydroepiandrosterone hybrids, which would effectively induce endoplasmic reticulum stress (ERS) and lead to apoptosis with outstanding in vitro and in vivo anti-melanoma effects. The lead compound IId among various steroids conjugated with peptides and pyridines showed effective in vivo activity in B16 xenograft mice: in medium- and high-dose treatment groups (60 and 80 mg/kg), compound IId would significantly inhibit the growth of tumours by 98%-99% compared to the control group, with the highest survival rate as well...
March 7, 2024: European Journal of Medicinal Chemistry
https://read.qxmd.com/read/38449627/prospective-role-of-lusianthridin-in-attenuating-cadmium-induced-functional-and-cellular-damage-in-rat-thyroid
#26
JOURNAL ARTICLE
Teng Gao, Sijia Luo, Hongguang Li, Zijie Su, Qinghui Wen
The thyroid represents the most prevalent form of head and neck and endocrine cancer. The present investigation demonstrates the anticancer effects of Lusianthridin against cadmium (Cd)-induced thyroid cancer in rats. Swiss Wistar rats were utilized in this experimental study. Cd was employed to induce thyroid cancer, and the rats were divided into different groups, receiving oral administration of Lusianthridin (20 mg/kg) for 14 days. Thyroid parameters, deiodinase levels, hepatic parameters, lipid parameters, and antioxidant parameters were respectively estimated...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38447334/effects-of-endoplasmic-reticulum-stress-on-chondrocyte-apoptosis-via-the-pi3k-akt-signaling-pathway
#27
JOURNAL ARTICLE
Libo Zhou, Fan Wu, Jing Wang, Yuqing Zhao, Gaoyi Wu, Yucheng Su
Chondrocytes undergo endoplasmic reticulum stress (ERS)-induced apoptosis under abnormal stimulation. However, the underlying molecular mechanism remains unclear. We investigated the regulatory effect of the PI3K/AKT signaling pathway on ERS and its effect on chondrocyte apoptosis. In addition, we established a unilateral anterior crossbite (UAC) model in rats to induce temporomandibular joint osteoarthritis (TMJOA). Chondrocytes were isolated from the temporomandibular joints and treated with lipopolysaccharide (LPS) in vitro...
February 25, 2024: Tissue & Cell
https://read.qxmd.com/read/38443366/retraction-note-grp78-determines-glioblastoma-sensitivity-to-uba1-inhibition-induced-upr-signaling-and-cell-death
#28
Guanzheng Liu, Jiefeng Yu, Runqiu Wu, Lin Shi, Xu Zhang, Wanhong Zhang, Xiaomin Zhong, Yifeng Wang, Huan Li, Yang Shen, Changyong Wu, Rutong Yu, Mingshan Niu, Xuejiao Liu
No abstract text is available yet for this article.
March 5, 2024: Cell Death & Disease
https://read.qxmd.com/read/38439529/%C3%AE-sitosterol-attenuates-anlotinib-resistance-in-non-small-cell-lung-cancer-cells-by-inhibiting-mir-181a-3p-shq1-signaling
#29
JOURNAL ARTICLE
Li-Huai Wang, Yin-Hui Sun, Hua Liu, Xiao Yang, Zhi Wen, Xue-Fei Tian
Anlotinib is used for the treatment of advanced non-small cell lung cancer; however, the emergence of drug resistance limits its clinical application. β-sitosterol may also be used to treat lung cancer, but there have been no studies evaluating β-sitosterol against anlotinib-resistant lung cancer. The purpose of this study was to determine the mechanism by which β-sitosterol enhances the sensitivity of lung cancer cells to anlotinib. A549 cells were treated with different concentrations of anlotinib to generate anlotinib-resistant cells (A549/anlotinib cells)...
March 2024: Chemical Biology & Drug Design
https://read.qxmd.com/read/38434585/maresin-1-attenuates-sepsis-associated-acute-kidney-injury-via-suppressing-inflammation-endoplasmic-reticulum-stress-and-pyroptosis-by-activating-the-ampk-sirt3-pathway
#30
JOURNAL ARTICLE
Miaomiao Sun, Fuquan Wang, Haopeng Li, Mengyu Li, Yu Wang, Chenchen Wang, Yan Zhang, Dingyu Zhang, Jianhua Li, Shanglong Yao
BACKGROUND: Sepsis-associated acute kidney injury (SA-AKI) is a common complication in patients with sepsis, triggering high morbidity and mortality. Maresin-1 (MaR1) is a pro-resolution lipid mediator that promotes the resolution of acute inflammation and protects organs from inflammation. METHODS: In this study, we established an SA-AKI model using cecal ligation and puncture (CLP) and investigated the effect and mechanism of MaR1. The blood and kidneys were harvested 24 hours after surgery...
2024: Journal of Inflammation Research
https://read.qxmd.com/read/38434326/molecular-mechanism-of-atf6-in-unfolded-protein-response-and-its-role-in-disease
#31
REVIEW
Yingying Lei, Hong Yu, Shaoxue Ding, Hui Liu, Chunyan Liu, Rong Fu
Activating transcription factor 6 (ATF6), an important signaling molecule in unfolded protein response (UPR), plays a role in the pathogenesis of several diseases, including diseases such as congenital retinal disease, liver fibrosis and ankylosing spondylitis. After endoplasmic reticulum stress (ERS), ATF6 is activated after separation from binding immunoglobulin protein (GRP78/BiP) in the endoplasmic reticulum (ER) and transported to the Golgi apparatus to be hydrolyzed by site 1 and site 2 proteases into ATF6 fragments, which localize to the nucleus and regulate the transcription and expression of ERS-related genes...
March 15, 2024: Heliyon
https://read.qxmd.com/read/38422912/prediction-of-the-binding-location-between-the-nuclear-inhibitor-of-dna-binding-and-differentiation-2-id2-and-hspa5
#32
JOURNAL ARTICLE
Abdo A Elfiky
Glucose-regulated protein 78 (GRP78), also termed HSPA5, was widely studied in cancer. It was recently approved that GRP78 has nuclear localization potential that sheds light on its role in cancer development. The inhibitor of DNA binding and differentiation 2 (ID2) is the nuclear component that associates with GRP78. The interaction between these two proteins is not understood clearly. In the current study, the binding pattern of GRP78/ID2 is predicted using computational methods. Protein-protein docking is used along with molecular dynamics simulation...
February 17, 2024: Pathology, Research and Practice
https://read.qxmd.com/read/38419890/crocin-protects-against-endoplasmic-reticulum-stress-related-tubular-injury-in-diabetic-nephropathy-via-the-activation-of-the-pi3k-akt-nrf2-pathway
#33
JOURNAL ARTICLE
Guiying Wang, Jiuhon Deng, Zhou Hua
OBJECTIVES: Diabetic nephropathy (DN) is the main cause of end-stage renal disease, but the current treatment is not satisfactory. Crocin is a major bioactive compound of saffron with antioxidant and anti-endoplasmic reticulum stress (ERS) abilities used to treat diabetes. This study specifically investigated whether crocin has a regulatory role in renal injury in DN. MATERIALS AND METHODS: The experiment was divided into control, (db/m mice), model (db/db mice), and experimental groups (db/db mice were intraperitoneally injected with 40 mg/kg crocin)...
2024: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/38419883/protective-effects-of-naringin-against-oxaliplatin-induced-testicular-damage-in-rats-involvement-of-oxidative-stress-inflammation-endoplasmic-reticulum-stress-apoptosis-and-histopathology
#34
JOURNAL ARTICLE
Nurhan Akaras, Cihan Gür, Cuneyt Caglayan, Fatih Mehmet Kandemir
OBJECTIVES: Oxaliplatin (OXL) is a platinum-based chemotherapeutic agent widely used in the treatment of colorectal cancer. Unfortunately, this important drug also causes unwanted side effects such as neuropathy, ototoxicity, and testicular toxicity. This study aimed to investigate the possible protective effects of naringin (NRG) against OXL-induced testicular toxicity in rats. MATERIALS AND METHODS: In the present study, rats were injected with OXL (4 mg/kg, b...
2024: Iranian Journal of Basic Medical Sciences
https://read.qxmd.com/read/38412940/intestinal-heat-shock-proteins-in-metabolic-syndrome-novel-mediators-of-obesity-and-its-comorbidities-resolution-after-metabolic-surgery
#35
REVIEW
Giulia Angelini, Sara Russo, Geltrude Mingrone
Over the past 40 years, the prevalence of obesity has risen dramatically, reaching epidemic proportions. Metabolic surgery has proven to be highly effective in treating obesity, leading to significant improvements or complete resolution of obesity-related comorbidities. Research conducted in both animals and humans suggests that the metabolic benefits achieved through metabolic surgery cannot be solely attributed to weight loss. Indeed, there has been an increasing recognition of intestinal inflammation as a novel factor influencing obesity...
February 25, 2024: Cell Stress & Chaperones
https://read.qxmd.com/read/38403724/betulinic-acid-induces-apoptosis-of-hela-cells-via-ros-dependent-er-stress-and-autophagy-in-vitro-and-in-vivo
#36
JOURNAL ARTICLE
Ping Chen, Xueer Zhang, Qiaomiao Fang, Zhongxiang Zhao, Chaozhan Lin, Yuan Zhou, Fangle Liu, Chenchen Zhu, Aizhi Wu
Betulinic acid (BA), a naturally occurring lupane-type triterpenoid, possesses a wide range of potential activities against different types of cancer. However, the molecular mechanisms involved in anti-cervical cancer about BA were rarely investigated. Herein, the role of BA in cervical cancer suppression by ROS-mediated endoplasmic reticulum stress (ERS) and autophagy was deeply discussed. The findings revealed that BA activated Keap1/Nrf2 pathway and triggered mitochondria-dependent apoptosis due to ROS production...
February 25, 2024: Journal of Natural Medicines
https://read.qxmd.com/read/38403685/-blood-brain-barrier-breakdown-and-autoimmune-cerebellar-ataxia
#37
JOURNAL ARTICLE
Fumitaka Shimizu
Autoimmune cerebellar ataxia is a disease entity that affects the cerebellum and is induced by autoimmune mechanisms. The disease is classified into several etiologies, including gluten ataxia, anti-glutamate decarboxylase (GAD) ataxia, paraneoplastic cerebellar degeneration, primary autoimmune cerebellar ataxia and postinfectious cerebellar ataxia. The autoimmune response in the periphery cross-reacts with similar antigens in the cerebellum due to molecular mimicry. Breakdown of the blood‒brain barrier (BBB) could potentially explain the vulnerability of the cerebellum during the development of autoimmune cerebellar ataxia, as it gives rise to the entry of pathogenic autoantibodies or lymphocytes into the cerebellum...
February 23, 2024: Rinshō Shinkeigaku, Clinical Neurology
https://read.qxmd.com/read/38401021/inhibition-of-endoplasmic-reticulum-stress-improves-chronic-ischemic-hippocampal-damage-associated-with-suppression-of-ire1%C3%AE-traf2-ask1-jnk-dependent-apoptosis
#38
JOURNAL ARTICLE
Kai Kang, Shu-Hui Chen, Da-Peng Wang, Feng Chen
Chronic cerebral ischemia is a complex form of stress, of which the most common hemodynamic characteristic is chronic cerebral hypoperfusion (CCH). Lasting endoplasmic reticulum (ER) stress can drive neurological disorders. Targeting ER stress shows potential neuroprotective effects against stroke. However, the role of ER stress in CCH pathological processes and the effects of targeting ER stress on brain ischemia are unclear. Here, a CCH rat model was established by bilateral common carotid artery occlusion...
February 24, 2024: Inflammation
https://read.qxmd.com/read/38395010/microplastics-induced-endoplasmic-reticulum-stress-to-format-an-inflammation-and-cell-death-in-hepatocytes-of-carp-cyprinus-carpio
#39
JOURNAL ARTICLE
Jie Cui, Mengran Zhu, Xiaoran Sun, Jie Yang, Mengyao Guo
Microplastics (MPs) are a serious threat to the living environment of aquatic organisms. However, there are fewer studies on the toxicity of microplastics to freshwater organisms. This study aimed to establish a polystyrene microplastics (PS-MPs) model by feeding carp (Cyprinus carpio) PS-MP (1000 ng/L) particles 8 μm in size. HE staining revealed a mass of inflammatory cells infiltrated in the carp hepatopancreas. The activities of alkaline phosphatase (AKP), aspartate transaminase (AST), lactate dehydrogenase (LDH), and alanine transaminase (ALT) were strengthened considerably, suggesting that PS-MPs cause injury to the hepatopancreas of carp...
February 19, 2024: Aquatic Toxicology
https://read.qxmd.com/read/38394641/grp78-contributes-to-the-beneficial-effects-of-sglt2-inhibitor-on-proximal-tubular-cells-in-dkd
#40
JOURNAL ARTICLE
Atsuko Nakatsuka, Satoshi Yamaguchi, Jun Wada
Beneficial effects of SGLT2 inhibitors on kidney function are well-known; however, their molecular mechanisms are not fully understood. We focused on 78 kDa glucose-regulated protein (GRP78) and its interaction with SGLT2 and Integrin ß1 beyond the chaperone property of GRP78. In STZinduced diabetic mouse kidneys, GRP78, SGLT2, and Integrin ß1 increased in the plasma membrane fraction, while they were suppressed by canagliflozin. The altered subcellular localization of GRP78/Integrin ß1 in STZ mice promoted epithelial mesenchymal transition (EMT) and fibrosis, which were mitigated by canagliflozin...
February 23, 2024: Diabetes
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