keyword
https://read.qxmd.com/read/38380572/integrating-serum-pharmacochemistry-and-network-pharmacology-to-explore-the-molecular-mechanisms-of-acanthopanax-senticosus-rupr-maxim-harms-on-attenuating-doxorubicin-induced-myocardial-injury
#1
JOURNAL ARTICLE
Xiaoxu Zhang, Qi Zhang, Menghan Yu, Yanfei Zhang, Tianzhu He, Zhidong Qiu, Ye Qiu, Weinan Wang
ETHNOPHARMACOLOGICAL RELEVANCE: Acanthopanax senticosus (Rupr. & Maxim.) Harms (AS), also known as Eleutherococcus senticosus (Rupr. & Maxim.) Maxim. or Siberian ginseng, has a rich history of use as an adaptogen, a substance believed to increase the body's resistance to stress, fatigue, and infectious diseases. As a traditional Chinese medicine, AS is popular for its cardioprotective effects which can protect the cardiovascular system from hazardous conditions. Doxorubicin (DOX), on the other hand, is a first-line chemotherapeutic agent against a variety of cancers, including breast cancer, lung cancer, gastric cancer, and leukemia, etc...
January 30, 2024: Journal of Ethnopharmacology
https://read.qxmd.com/read/38179774/plant-derived-extracts-plus-vitamin-e-and-or-aloe-vera-protect-against-intrinsic-extrinsic-stressor-in-human-skin-in-vitro-and-clinical-evidence
#2
JOURNAL ARTICLE
Ganesh Diwakar, Lisa Barnes, Melanie Riggs, Helen Knaggs, Zoe Diana Draelos
BACKGROUND: Humans are exposed to physical, biological, chemical, and psychological stressor throughout their life span. In recent years many medicinal plants have been shown to induce stress adapting and protective functions. Plant-derived extracts and vitamin E exhibit stress protection or resistance by normalizing cellular homeostasis and enhancing resistance to toxic stimuli to overcome cellular damage. Here we report the evaluation of a topical preparation (product test materials; PTM) containing an ingredient blend of Rhodiola Rosea, Eleutherococcus Senticosus (Siberian Ginseng), Rhaponticum Carthamoides, Inonotus Obliqus, and Slegainella Lepidophylla as the base formula and tested the addition of Lespedeza Capitata (leaf/stem) extract plus vitamin E and/or Aloe Vera to determine the induced protective functions in human skin when challenged with intrinsic and extrinsic stressors...
December 29, 2023: Frontiers in Bioscience (Landmark Edition)
https://read.qxmd.com/read/37979523/precursor-ions-guided-comprehensive-profiling-of-triterpenoid-saponins-from-the-eleutherococcus-senticosus-stems-and-their-neuroprotective-effect-evaluation
#3
JOURNAL ARTICLE
Ying-Xin Zhou, Wen-Jie Luo, Tian-Tian Zhou, Yu Zhou, Hui-Lin Li, Fei Sun, Yue-Wei Ge, Xiu-Hong Piao
Triterpenoid saponins (TS) are the main constituents of Eleutherococcus senticosus, also termed as Siberian ginseng or Ciwujia, a widely used herb in China, Japan, Korea, and Russia for its beneficial effects on memory enhancement, tonifying, heart-nourishing, and tranquilizing. Although the stems, rhizomes, and roots are used identically, a preliminary experiment found TS were specifically distributed in stems rather than the underground parts. However, a comprehensive profiling of the TS compounds in E. senticosus stems (ESS) is still absent...
November 7, 2023: Journal of Pharmaceutical and Biomedical Analysis
https://read.qxmd.com/read/37101730/a-comprehensive-review-of-herbal-supplements-used-for-persistent-symptoms-attributed-to-lyme-disease
#4
REVIEW
Allison Thompson, Lauren M Hynicka, Kalpana D Shere-Wolfe
CONTEXT: Lyme disease is the most common, tick-borne disease in the USA. While most patients successfully recover with antibiotics, some patients experience persistent symptoms for months to years. Patients who attribute chronic symptoms to Lyme disease commonly use herbal supplements. The complexity, variability in dose and formulation, and lack of data for these herbal compounds make it difficult to assess their efficacy and safety. OBJECTIVE: This review examines the evidence for the antimicrobial activity, safety, and drug-drug interactions of 18 herbal supplements that patients commonly use for treatment of persistent symptoms attributed to Lyme disease...
March 2023: Integrative Medicine
https://read.qxmd.com/read/36576665/molecular-mechanism-of-acanthopanax-senticosus-in-the-treatment-of-alzheimer-s-disease-based-on-network-pharmacology-and-molecular-docking
#5
JOURNAL ARTICLE
Feng Kuang, Tao Xiang
Alzheimer's disease is the most common neurodegenerative disease. Acanthopanax senticosus, also known as Ciwujia or Siberian ginseng in Chinese, has a wide range of antioxidant and anti-inflammatory activities. The study aims to explore the action mechanism of A. senticosus against Alzheimer's disease using network pharmacology and molecular docking. The active ingredients and targets of A. senticosus were searched through the ETCM database, and Alzheimer's disease-related targets were obtained through the OMIM and GeneCards databases...
December 28, 2022: Molecular Diversity
https://read.qxmd.com/read/35921056/protective-effects-of-isofraxidin-against-scopolamine-induced-cognitive-and-memory-impairments-in-mice-involve-modulation-of-the-bdnf-creb-erk-signaling-pathway
#6
JOURNAL ARTICLE
Bingliang Lian, Jingwen Gu, Chen Zhang, Zhicong Zou, Meng Yu, Fanghong Li, Xiaoli Wu, Allan Zijian Zhao
BACKGROUND: Isofraxidin is a coumarin compound mainly isolated from several traditional and functional edible plants beneficial for neurodegenerative diseases, including Sarcandra glabra and Apium graveolens, and Siberian Ginseng. OBJECTIVE: This study aimed to assess effects of isofraxidin against memory impairments and cognition deficits in a scopolamine-induced mouse model. MATERIALS & METHODS: Animals were randomly divided into 6 groups, control, vehicle, donepezil (10 mg/kg, p...
August 3, 2022: Metabolic Brain Disease
https://read.qxmd.com/read/33891787/chromosomal-scale-genome-assembly-of-eleutherococcus-senticosus-provides-insights-into-chromosome-evolution-in-araliaceae
#7
JOURNAL ARTICLE
Zijiang Yang, Shanshan Chen, Shufen Wang, Ying Hu, Guanghui Zhang, Yang Dong, Shengchao Yang, Jianhua Miao, Wei Chen, Jun Sheng
Siberian ginseng (Eleutherococcus senticosus, also known as ciwujia) belongs to the Araliaceae family, which contains more than 1,500 species in 41 genera with diverse chromosome numbers and genome sizes. General consensus posits that ancient whole-genome duplication events and rapid evolutionary radiation are the driving forces for this variation in genome properties. In an attempt to generate more genomic information for the Araliaceae family, we report a 1.30 Gb high-quality draft genome assembly (contig N50 = 309...
April 23, 2021: Molecular Ecology Resources
https://read.qxmd.com/read/33650944/modulation-of-the-hypothalamic-pituitary-adrenal-hpa-axis-by-plants-and-phytonutrients-a-systematic-review-of-human-trials
#8
JOURNAL ARTICLE
Adrian L Lopresti, Stephen J Smith, Peter D Drummond
INTRODUCTION: The hypothalamic-pituitary-adrenal (HPA) axis plays a central role in the stress response. Plants, herbs, spices, and plant-based nutrients may influence HPA-axis activity. OBJECTIVE: To evaluate randomised controlled, human trials assessing the effects of single plants or phytonutrients on HPA-axis related hormones. METHODS: A systematic review of PubMed, Cochrane library, and the Cumulative Index to Nursing and Allied Health Literature was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines...
August 2022: Nutritional Neuroscience
https://read.qxmd.com/read/33650674/acanthopanax-senticosus-harms-extract-causes-g0-g1-cell-cycle-arrest-and-autophagy-via-inhibition-of-rubicon-in-human-liver-cancer-cells
#9
JOURNAL ARTICLE
Yutaka Kawano, Maki Tanaka, Masaki Fujishima, Eri Okumura, Hideo Takekoshi, Kohichi Takada, Osamu Uehara, Yoshihiro Abiko, Hidekatsu Takeda
Acanthopanax senticosus (Rupr. et Maxim) Harms (ASH), also known as Siberian ginseng or eleuthero, is a hardy shrub native to China, Korea, Russia and the northern region of Japan. ASH is used for the treatment of several diseases such as heart disease, hypertension, rheumatoid arthritis, allergies, chronic bronchitis, diabetes and cancer. In the present study, the inhibitory effect of the root extract of ASH (ASHE) on HuH‑7 and HepG2 liver cancer cells was examined. ASHE suppressed liver cancer cell proliferation by inducing cell cycle arrest at the G0/G1 phase, as well as apoptosis, as indicated by the increased number of Annexin V and 7‑AAD‑positive cells...
March 2021: Oncology Reports
https://read.qxmd.com/read/33571255/growth-performance-physiological-parameters-and-transcript-levels-of-lipid-metabolism-related-genes-in-hybrid-yellow-catfish-tachysurus-fulvidraco-%C3%A2-%C3%A3-pseudobagrus-vachellii-%C3%A2-fed-diets-containing-siberian-ginseng
#10
JOURNAL ARTICLE
Ming Xiao Li, Jun Qiang, Jing Wen Bao, Yi Fan Tao, Hao Jun Zhu, Pao Xu
In high-density aquaculture, fish health can suffer because of excessive feeding, which causes fatty liver disease. Siberian ginseng (Acanthopanax senticosus) has been used as a feed additive to promote animal growth, immunity, and lipid metabolism. In this study, we explored the effects of A. senticosus on the physiology of hybrid yellow catfish (Tachysurus fulvidraco ♀ × Pseudobagrus vachellii ♂). A control group and five groups fed diets containing A. senticosus (0.5, 1, 2, 4, and 8 g A. senticosus/kg feed) were established and maintained for 8 weeks...
2021: PloS One
https://read.qxmd.com/read/33549279/traditional-and-current-use-of-ginseng
#11
REVIEW
Amanda J Flagg
Ginseng is one of the oldest documented herbs still in use today. It is known as a panacea for many disease states and for the enhancement of wellness affecting most body systems. Very few side effects are experienced, but there are considerations with its use. Three major types of ginseng are described. Asian ginseng is more potent than American ginseng; however, most supplements come from American and Asian types of ginseng. Purchases should be made from reputable sources owing to the lack of standardization of the production of herbal supplements...
March 2021: Nursing Clinics of North America
https://read.qxmd.com/read/33373286/leaf-spot-caused-by-boeremia-linicola-on-siberian-ginseng-in-china
#12
JOURNAL ARTICLE
Yi Ming Guan, Shu Na Zhang, Ying Ying Ma, Yue Zhang
Siberian ginseng ( Eleutherococcus sessiliflorus (Rupr. & Maxim.) S. Y. Hu, Araliaceae), is a perennial medicinal plant that is widely cultivated in China. Leaf spot was observed in 2- and 3-year-old Siberian ginseng in Zuojia County (126°05'23.2″E, 44°03'09.5″N), northeast China, in August 2019. Polygonal or irregular black spots ranging from 2 to 9 mm in diameter were found on infected leaves, and each leaf had dozens of spots. The green color around the lesions gradually faded. As the disease progressed, the spots withered and multiple lesions merged into large disease spots, causing leaf wilting (Fig...
December 29, 2020: Plant Disease
https://read.qxmd.com/read/32893745/vitamin-e-and-ginseng-supplementation-to-enhance-female-sexual-function-a-randomized-double-blind-placebo-controlled-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
Kiandokht Ghamari, Ladan Kashani, Morteza Jafarinia, Borna Tadayon Najafabadi, Kamyar Shokraee, Sophia Esalatmanesh, Shahin Akhondzadeh
Female sexual disorders (FSD) are a spectrum of disorders common among women, especially in their middle age, which can reduce the female quality of life substantially. We aimed to evaluate the effects of a combined vitamin E and ginseng supplement on amelioration of female sexual dysfunction. In a 6-week, double-blind, randomized, placebo-controlled clinical trial, participants, suffering from sexual dysfunction based on the female sexual function index (FSFI) questionnaire, were randomly allocated to receive the supplement (100 IU vitamin E, 67 mg Korean ginseng, and 40 mg Siberian ginseng) or placebo daily...
November 2020: Women & Health
https://read.qxmd.com/read/32757816/a-comprehensive-in-silico-exploration-of-pharmacological-properties-bioactivities-and-cox-2-inhibitory-potential-of-eleutheroside-b-from-eleutherococcus-senticosus-rupr-maxim-maxim
#14
JOURNAL ARTICLE
Sium Ahmed, Dil Afroj Moni, Kailas Dashrath Sonawane, Kee Yoeup Paek, Abdullah Mohammad Shohael
Eleutherococcus senticosus (Rupr. & Maxim.) Maxim., popularly known as 'Siberian ginseng', is an important medicinal plant. Pharmacologically active compounds of this plant are called eleutherosides and among them, eleutheroside B is the most prevalent. The E. senticosus has been reported to have many medicinal properties however; very few studies are reported to understand the medicinal properties of eleutheroside B. Consequently, in the present study various computational tools have been used to predict the drug-likeness, bioactivities, and pharmacokinetic properties of eleutheroside B...
August 6, 2020: Journal of Biomolecular Structure & Dynamics
https://read.qxmd.com/read/32315950/isofraxidin-ameliorated-influenza-viral-inflammation-in-rodents-via-inhibiting-platelet-aggregation
#15
JOURNAL ARTICLE
Lei Jin, Zhen-Hua Ying, Chen-Huan Yu, Huan-Huan Zhang, Wen-Ying Yu, Xiao-Ning Wu
Platelets have been proved to exacerbate influenza infection and its complications. Inhibition of platelet activation may be a feasible method for preventing severe infection and secondary acute lung injury (ALI). Isofraxidin (IFD) is a natural coumarin isolated from the plants Sarcandra glabra and Siberian ginseng, and exerts anticancer, antioxidant and antiinflammatory effects. In the present study, we examined the therapeutic effects of IFD in ADP- or arachidonic acid (AA)-induced platelet aggregation model and in influenza A virus (IAV)-induced ALI mouse model...
April 18, 2020: International Immunopharmacology
https://read.qxmd.com/read/32065954/a-comparative-study-on-root-and-bark-extracts-of-eleutherococcus-senticosus-and-their-effects-on-human-macrophages
#16
JOURNAL ARTICLE
Lu Jin, Michael Schmiech, Menna El Gaafary, Xinlei Zhang, Tatiana Syrovets, Thomas Simmet
BACKGROUND: Eleutherococcus senticosus or Siberian ginseng is a medicinal plant containing adaptogenic substances believed to regulate immune responses. Both, the root and stem bark are commonly used in traditional medicines. PURPOSE: The purpose of the present study is to chemically characterize E. senticosus root and bark extracts and to compare their effects on functions of human primary macrophages. STUDY DESIGN AND METHODS: HPLC-DAD-MS analysis was used to characterize chemical constituents of alcoholic extracts from E...
February 6, 2020: Phytomedicine
https://read.qxmd.com/read/31388349/a-review-on-the-immunomodulatory-activity-of-acanthopanax-senticosus-and-its-active-components
#17
REVIEW
Kit-Man Lau, Grace Gar-Lee Yue, Yuk-Yu Chan, Hin-Fai Kwok, Si Gao, Chun-Wai Wong, Clara Bik-San Lau
Acanthopanacis Senticosi Radix et Rhizoma seu Caulis, the dried root and rhizome or stem of Acanthopanax senticosus , is commonly known as Siberian ginseng or Ciwujia in Chinese. It is used all over the world as an adaptogen to enhance physical and mental performance for the sake of normal physiological functioning of human bodies under stress. In the theory of traditional Chinese medicine, Ciwujia can strengthen the spleen that is an essential organ for immunological response. Its traditional applications include inflammation, fatigue and cancer in which the immune-regulating function is always involved...
2019: Chinese Medicine
https://read.qxmd.com/read/31379212/biologically-synthesized-green-gold-nanoparticles-from-siberian-ginseng-induce-growth-inhibitory-effect-on-melanoma-cells-b16
#18
JOURNAL ARTICLE
Fenglian Wu, Jun Zhu, Guoliang Li, Jiaxin Wang, Vishnu Priya Veeraraghavan, Surapaneni Krishna Mohan, Qingfu Zhang
Siberian ginseng , perennial herb belongs to Araliaceae family used in traditional medicines to treat hypertension, thrombus, inflammation and cancer. In the present study, we biosynthesized goldnanoparticles using Siberian ginseng aqeous extract in a cost effective manner. The synthesized Siberian ginseng gold nanoparticle (SG-GNPs) were characterized using UV-Vis spec, HR-TEM, XRD, FTIR, SAED analysis. UV-Vis spectroscopic analysis showed a surface Plasmon resonance peak at 538 nm which does not reduce till 30 days of incubation...
December 2019: Artificial Cells, Nanomedicine, and Biotechnology
https://read.qxmd.com/read/30299441/isofraxidin-targets-the-tlr4-md-2-axis-to-prevent-osteoarthritis-development
#19
JOURNAL ARTICLE
Jialei Jin, Xingfang Yu, Zhichao Hu, Shangkun Tang, Xinyang Zhong, Jianchen Xu, Ping Shang, Yixing Huang, Haixiao Liu
Osteoarthritis (OA) is a major cause of joint pain and disability, resulting in large socioeconomic costs worldwide. Isofraxidin (ISO), a bioactive coumarin compound isolated from the functional foods Siberian ginseng and Apium graveolens, exerts anti-inflammatory effects in a variety of diseases. However, no studies have reported the protective effects of ISO against OA development. Accordingly, this study aimed to assess the therapeutic effect of ISO in human OA chondrocytes, and in a mouse model of OA induced by destabilisation of the medial meniscus (DMM)...
November 14, 2018: Food & Function
https://read.qxmd.com/read/29434755/anti-tumour-effects-of-polysaccharide-extracted-from-acanthopanax-senticosus-and-cell-mediated-immunity
#20
JOURNAL ARTICLE
Qinglong Meng, Jingzhi Pan, Yajing Liu, Li Chen, Yueying Ren
Acanthopanax senticosus , also known as Siberian ginseng, is widely distributed throughout northern Asia and used in traditional Chinese medicine; it has been reported to prevent a number of diseases. However, the association between the antitumour and immunostimulatory activities of polysaccharide extracted from A. senticosus (ASPS) remains to be elucidated. The aim of the present study was to investigate the anti-tumour and immunomodulatory effects of polysaccharide extracted from ASPS on Crocker sarcoma S180 , hepatic carcinoma H22 and uterine cervical carcinoma U14 tumour cell lines implanted in mice...
February 2018: Experimental and Therapeutic Medicine
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