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Colorectal cancer in egypt

Amira B Kassem, Salem Eid Salem, Mohamed E Abdelrahim, Amira S A Said, Ahmad Salahuddin, Marwa Mahmoud Hussein, Abeer A Bahnassy
BACKGROUND: The impact of Excision repair cross-complementation group 1 (ERCC1) and group 2 (ERCC2) expression levels on the efficacy of oxaliplatin-based chemotherapy is still controversial. The present study was conducted to determine the predictive value of these molecular biomarkers in stage III and IV colorectal cancer (CRC) patients receiving oxaliplatin (OX)-based chemotherapy as first-line treatment. METHODS: The study included 80 CRC patients who received first line oxaliplatin based chemotherapy The expression levels of ERCC1 and ERCC2-mRNA and proteins were determined in the primary tumors by quantitative real time reverse transcription polymerase chain reaction(RT-qPCR) and immunohistochemistry (IHC); respectively...
January 12, 2017: Experimental and Molecular Pathology
M F Ragab, R A Assal, M M Abdelrahman, G Elsisi
No abstract text is available yet for this article.
November 2016: Value in Health: the Journal of the International Society for Pharmacoeconomics and Outcomes Research
S P K Shiao, C H Yu
The methylenetetrahydrofolate reductase (MTHFR) gene is one of the most investigated of the genes associated with chronic human diseases because of its associations with hyperhomocysteinemia and toxicity. It has been proposed as a prototype gene for the prevention of colorectal cancer (CRC). The major objectives of this meta-analysis were to examine the polymorphism-mutation patterns of MTHFR and their associations with risk for CRC as well as potential contributing factors for mutations and disease risks. This analysis included 33,626 CRC cases and 48,688 controls across 92 studies for MTHFR 677 and 16,367 cases and 24,874 controls across 54 studies for MTHFR 1298, comprising data for various racial and ethnic groups, both genders, and multiple cancer sites...
July 2016: Biological Research for Nursing
Livia Giordano, Luigi Bisanti, Giuseppe Salamina, Rosemary Ancelle Park, Hélène Sancho-Garnier, Josep Espinas, Christine Berling, Gad Rennert, Roberta Castagno, Marta Dotti, Lina Jaramillo, Nereo Segnan
BACKGROUND: The EUROMED CANCER Network project aims to support non-EU Mediterranean countries in the development of cancer early detection and screening policies. METHODS: Through a structured questionnaire information from 15 countries (Albania, Algeria, Bosnia and Herzegovina (BiH), Croatia, Egypt, Jordan, UN Interim Administration Mission in Kosovo, Lebanon, Montenegro, Morocco, Palestinian National Authority, Serbia, Syria, Tunisia and Turkey) were collected on cancer epidemiology and control...
February 2016: European Journal of Public Health
Anwar Tawfik Amin, Badawy M Ahmed, Salah Mabrouk Khallaf
BACKGROUND: Laparoscopic colectomy has been shown to have significant short- and long-term benefits compared to open approach. The incorporation of laparoscopy in developing countries is challenging, due to the high costs of equipment and lack of expertise. The aim of this study was to evaluate the safety and feasibility of laparoscopic colorectal surgery for cancer that could be performed in developing countries under different circumstances in developed countries. METHODS: Thirty-seven patients (23 males and 14 females) with colorectal cancer with a median age of 46 years (39-72) have been enrolled for laparoscopic colo-rectal surgery in a tertiary center in Egypt (South Egypt Cancer Institute) with the trend of reuse of some disposable laparoscopic instruments...
June 2015: Journal of the Egyptian National Cancer Institute
Eman Mohamed Mahfouz, Refaat Raouf Sadek, Wafaa Mohamed Abdel-Latief, Fadia Abdel-Hamed Mosallem, Ebtesam Esmail Hassan
BACKGROUND: Colorectal cancer (CRC) is the third most common cancer worldwide, after lung and breast cancer, and is associated with the population dietary and lifestyle factors. AIM: To determine the relation between dietary and lifestyle factors and development of CRC in patients attending Minia oncology centre and compare them with their control. METHODS: Study included 150 CRC patients attending Minia oncology centre and 300 control subjects matched by age and sex...
December 2014: Central European Journal of Public Health
Mona Abdel-Hadi, Yasser Ismail, Layla Younis
In Egypt colorectal carcinoma (CRC) is the most common type of malignancy of the digestive system. Selectively inhibiting neoangiogenesis by targeting tumor-associated blood vessels is an important therapeutic strategy. Prostate specific membrane antigen (PSMA) is expressed in the tumor-associated neovasculature of most solid cancers making it an interesting therapeutic target. We thought to study the expression of PSMA in a series of CRCs in order to test for its possible use as a target for antiangiogenic cancer therapy in Egyptian patients...
November 2014: Pathology, Research and Practice
Yasser Abd El Kader, Gamal Emera, Ezzat Safwat, Heba A Kassem, Neemat M Kassem
BACKGROUND: Epidermal growth factor receptor (EGFR) and its downstream factors KRAS and BRAF are mutated in several types of cancer, affecting the clinical response to EGFR inhibitors. Mutations in the EGFR kinase domain predict sensitivity to the tyrosine kinase inhibitors gefitinib and erlotinib in lung adenocarcinoma, while activating point mutations in KRAS and BRAF confer resistance to the anti-EGFR monoclonal antibody cetuximab in colorectal cancer. The development of new generation methods for systematic mutation screening of these genes will allow more appropriate therapeutic choices...
March 2013: Journal of the Egyptian National Cancer Institute
Rehab M Samaka, Moshira M Abd El-Wahed, Hayam A Aiad, Mona A Kandil, Dalia R Al-Sharaky
John Cunningham virus (JCV) encodes an oncogenic T-antigen, which is capable of interacting with key growth regulatory pathways. JCV definite role as causal agent of human cancer, still awaits final confirmation. The present study was conducted to assess the possible role of JCV in Egyptian colorectal carcinoma (CRC) and correlate the expression with the clinicopathological features and survival. JCV in situ hybridization (ISH) signals and large T antigen immunoreactivity were examined in 87 colonic specimens...
April 2013: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
Darlene Veruttipong, Amr S Soliman, Samuel F Gilbert, Taylor S Blachley, Ahmed Hablas, Mohamed Ramadan, Laura S Rozek, Ibrahim A Seifeldin
AIM: To describe the clinical and epidemiologic profiles of the disease and to compare the findings with those generated from the previous hospital-based studies. METHODS: The Gharbiah cancer registry is the only population-based cancer registry in Egypt since 1998. We analyzed the data of all colorectal cancer patients included in the registry for the period of 1999-2007. All medical records of the 1364 patients diagnosed in Gharbiah during the study period were retrieved and the following information abstracted: age, residence, diagnosis date, grade, stage, topology, clinical characteristics, and histology variables...
August 14, 2012: World Journal of Gastroenterology: WJG
Ahmed A Zeeneldin, Fatma M Taha
BACKGROUND AND OBJECTIVE: Muslims constitute more than 20% of the world's population and have a significant share of its cancer cases. Many Muslim cancer patients witness the fasting month of Ramadan but we do not know which individuals elect to fast. DESIGN AND SETTING: Cross-sectional study conducted among Muslim cancer patients at the National Cancer Institute (NCI), Egypt, during Ramadan, Hijri 1430 (the month of fasting) August-September 2009. SUBJECTS AND METHODS: One-hundred and two patients being treated at the NCI were interviewed...
May 2012: Annals of Saudi Medicine
Ola M Omran, Mostafa Thabet
AIM: Prognosis of colorectal carcinoma depends on many factors, such as age and sex of patient; location; multiplicity; local extent and size of tumor, bowel obstruction, or perforation; as well as tumor microscopic type and grade; vascular and perineural invasion; and nodal and distant metastasis. The matrix metalloproteinases (MMPs) are a family of proteolytic enzymes strongly implicated in tumor invasion and metastasis, hence in tumor prognosis. The purpose of this study was to assess the role of MMP-2 and MMP-9 expression in colorectal tumorigenesis, invasion, and metastasis, hence their prognostic values...
April 2012: Ultrastructural Pathology
Hesham M El-Wakil, Fatma A Ali-Eldin, Amal S M Bakir, Nadia A Abdel-Kader, Mahmoud A Ellithy
Carcinoma of the large bowel is the fourth commonest cancer worldwide. The most frequent site for metastasis is the liver. Overall 30% of patients develop liver metastasis during the course of their illness; of these, 23% to 47% are synchronous lesions. These data are based on western studies. No data are published on patients with colorectal cancer from Egypt. We aimed to assess the incidence of colorectal liver metastasis in Egyptian patients and to evaluate the differences in the clinicopathological features and tumor behavior in patients with and without liver metastasis...
December 2011: Journal of the Egyptian Society of Parasitology
Taina T Nieminen, Soheir Shoman, Saad Eissa, Päivi Peltomäki, Wael M Abdel-Rahman
BACKGROUND: The outcome of colorectal cancer varies depending on ethnic origin. Egyptian colorectal carcinoma is surprisingly young-age disease with high proportion of rectal and advanced stage cancers. METHODS: We characterized 69 sporadic Egyptian colorectal cancers for promoter methylation at 24 tumor suppressor genes, microsatellite instability, and expression of mismatch repair, p53, and β-catenin proteins. Data were compared with 80 Western colorectal carcinoma of sporadic and familial origin from Finland...
January 2012: Cancer Epidemiology, Biomarkers & Prevention
Abdel Meguid Kassem, Nadia El-Guendy, Marwa Tantawy, Hala Abdelhady, Akmal El-Ghor, Abdel Hady Abdel Wahab
Mutations in the mitochondrial genome (mtDNA) are associated with different types of cancer, specifically colorectal cancer (CRC). However, few studies have been performed on precancerous lesions, such as ulcerative colitis (UC) lesions and adenomatous polyps (AP). The aim of this study was to identify mtDNA mutations in the cancerous and precancerous lesions of Egyptian patients. An analysis of the mutations found in six regions of the mtDNA genome (ND1, ND5, COI, tRNAser, D-loop 1, and 2) in 80 Egyptian patients (40 CRC, 20 UC, and 20 AP) was performed using polymerase chain reaction-single-strand conformational polymorphism techniques and followed up by direct sequencing...
November 2011: DNA and Cell Biology
Abdel Hady A Abdel Wahab, Abdel Meguid Kassem, Salwa Matter, Amany F Nour El Deen, Azza S Helmy, Mohsein M Ismaeil, Mohamed S Zakaria
BACKGROUND/AIMS: Colorectal cancer is one of the common cancers of the gastrointestinal tract in Egypt. It is characterized by a relatively earlier onset compared to that in the western world. Studying genetic alterations involved in colorectal cancer progression may help in identifying molecular biomarkers that can be used for early detection. METHODOLOGY: We analyzed DNA isolated from 83 cases including 38 colorectal carcinomas, 23 polyps (16 of which were adenomatous) and 22 cases with inflammatory bowel disease (IBD)...
November 2010: Hepato-gastroenterology
I H El-Sayed, M Lotfy, M Moawad
OBJECTIVE: Colorectal cancer (CRC) is more common in developed countries and is the third most common cancer among both men and women. CRC provides an attractive model of tumour biology with normal mucosa to adenoma to carcinoma sequence. The TF-antigen (Thomsen-Friedenreich) can be identified by galactose oxidase-Schiff's (GOS) reaction either on tissues or on rectal mucus samples from patients with CRC. TF antigen is expressed in the neoplastic mucosa and not expressed in colonic mucosa of normal subjects...
January 2011: European Review for Medical and Pharmacological Sciences
Hasan Elbatea, Mohamed Enaba, Galal Elkassas, Ferial El-Kalla, Asem Ahmed Elfert
BACKGROUND: In Egypt, few data are available on the outcome of colonoscopy. Epidemiologic studies have shown that inflammatory bowel disease (IBD) tends to increase. Endoscopists have reported an increasing incidence of IBD and colorectal cancer (CRC). This may be explained by an increasing index of suspicion and the availability of endoscopy. Population-based studies are lacking. AIM: The aim of our study was to retrospectively evaluate the patient characteristics and final diagnosis in patients subjected to colonoscopy in Tanta University Hospital and affiliated hospitals at the middle of Nile delta of Egypt, which is one of the most densely populated regions in the country...
July 2011: Digestive Diseases and Sciences
Fatma A Auf, Gamal K El-Eibdy, Youssef M Mosaad, Doaa M El-Ghannam, Emad E El-Masry
PURPOSE: To investigate the expression of cytokeratin 20 (CK20) and vascular endothelial growth factor (VEGF) in the peripheral blood of colorectal cancer (CRC) patients, and correlate the findings with the pathologic data of the patients. METHODS: This study was carried out on 50 subjects, 40 patients with histologically confirmed colorectal carcinoma undergoing elective surgery and 10 healthy individuals matched for age and sex. Total RNA extraction followed by real time quantitative RT-PCR and real time TaqMan quantitative assay for peripheral blood expression of CK20 and VEGF was done for both patients and controls...
September 2011: Journal of Oncology Pharmacy Practice
An-Chi Lo, Amr S Soliman, Hussein M Khaled, Ahmed Aboelyazid, Joel K Greenson
PURPOSE: Lifestyle factors and environmental exposures might help explain the risk of colorectal carcinoma in countries where the incidence is low, but unique patterns of young onset and a high proportion of rectal cancer exist. METHODS: We obtained detailed lifestyle information from 421 patients with colorectal cancer and 439 hospital-controls in Egypt. Logistic regression models were computed to evaluate the risk factors of colorectal carcinoma. RESULTS: A history of pesticide exposure and more frequently eating food directly from farms were significantly associated with a higher risk of colorectal carcinoma (odds ratio = 2...
May 2010: Diseases of the Colon and Rectum
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