Veena Somasundaram, Lisa A Ridnour, Robert Ys Cheng, Abigail J Walke, Noemi Kedei, Dibyangana D Bhattacharyya, Adelaide L Wink, Elijah F Edmondson, Donna Butcher, Andrew C Warner, Tiffany H Dorsey, David A Scheiblin, William Heinz, Richard J Bryant, Robert J Kinders, Stanley Lipkowitz, Stephen Tc Wong, Milind Pore, Stephen M Hewitt, Daniel W McVicar, Stephen K Anderson, Jenny Chang, Sharon A Glynn, Stefan Ambs, Stephen J Lockett, David A Wink
Antitumor immune polarization is a key predictor of clinical outcomes to cancer therapy. An emerging concept influencing clinical outcome involves the spatial location of CD8+ T cells, within the tumor. Our earlier work demonstrated immunosuppressive effects of NOS2 and COX2 tumor expression. Here, we show that NOS2/COX2 levels influence both the polarization and spatial location of lymphoid cells including CD8+ T cells. Importantly, elevated tumor NOS2/COX2 correlated with exclusion of CD8+ T cells from the tumor epithelium...
November 9, 2022: Redox Biology