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NSAID and breast cancer

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https://www.readbyqxmd.com/read/29788174/aspirin-abrogates-impairment-of-mammary-gland-differentiation-induced-by-early-in-life-second-hand-smoke-in-mice
#1
Julia Santucci-Pereira, Thomas J Pogash, Aman Patel, Navroop Hundal, Maria Barton, Anna Camoirano, Rosanna T Micale, Sebastiano La Maestra, Roumen Balansky, Silvio De Flora, Jose Russo
Epidemiological studies show that there is limited evidence that tobacco smoking causes breast cancer in humans. In rodents, many tobacco smoke chemicals cause mammary gland tumors. This study evaluated the mammary gland differentiation in mice exposed to environmental cigarette smoke (ECS), using 3R4F Kentucky reference cigarettes, starting after birth and continuing daily for 10 weeks (total particulate exposure 95 mg/m3; CO 610 ppm). We also analyzed the effects of oral administration of nonsteroidal anti-inflammatory drugs (NSAIDs), aspirin (1600mg/kg) or naproxen (320mg/kg), on mammary gland differentiation, either in unexposed or ECS-exposed mice...
May 17, 2018: Carcinogenesis
https://www.readbyqxmd.com/read/29746779/energy-metabolism-drugs-block-triple-negative-breast-metastatic-cancer-cell-phenotype
#2
Silvia Cecilia Pacheco-Velazquez, Diana Xochiquetzal Robledo-Cadena, Ileana Hernández-Reséndiz, Juan Carlos Gallardo-Pérez, Rafael Moreno-Sánchez, Sara Rodríguez-Enríquez
To establish alternative targeted therapies against triple negative (TN) breast cancer, (1) the energy metabolism and (2) the sensitivity of cell growth, migration and invasiveness towards metabolic, canonical and NSAID inhibitors was analyzed in MDA-MB-231 and MDA-MB-468, two TN metastatic breast cancer cell lines, under both normoxia (21% O2) and hypoxia (0.1% O2). For comparative purposes, analysis was also carried out in the less-metastatic breast MCF-7 cancer cells. Under normoxia, oxidative phosphorylation (OxPhos) was significantly higher (2-times) in MDA-MB-468 than in MDA-MB-231 and MCF-7 whereas their glycolytic fluxes and OxPhos and glycolytic protein contents were all similar...
May 10, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29718396/potential-benefit-of-intra-operative-administration-of-ketorolac-on-breast-cancer-recurrence-according-to-the-patient-s-body-mass-index
#3
Christine Desmedt, Romano Demicheli, Marco Fornili, Imane Bachir, Mariana Duca, Giulia Viglietti, Martine Berlière, Martine Piccart, Christos Sotiriou, Maurice Sosnowski, Patrice Forget, Elia Biganzoli
Background: Nonsteroidal anti-inflammatory drugs (NSAIDs) are currently used in some countries as analgesics in primary cancer surgery. Retrospective studies suggest that NSAIDs could reduce breast cancer recurrences. Because NSAIDs also act on biological mechanisms present in patients with increased adiposity, we aimed at assessing whether the intra-operative administration of ketorolac or diclofenac would be associated with a reduction of recurrence in patients with elevated body mass index (BMI)...
April 30, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29714143/cutaneous-application-of-celecoxib-for-inflammatory-and-cancer-diseases
#4
Oliesia Gonzales Quinones, Maria Bernadete Riemma Pierre
BACKGROUND: Nonsteroidal anti-inflammatory drugs (NSAIDs) and particularly selective cyclooxygenase-2 (COX-2) inhibitors such as celecoxib (Cxb) are considered promising cancer chemopreventive for colon, breast, prostate, lung, and skin cancers. However, the clinical application to the prevention is limited by concerns about safety, potential to serious toxicity (mainly for healthy individuals), efficacy and optimal treatment regimen. Cxb exhibits advantages as potent anti-inflammatory and gastrointestinal tolerance compared with conventional NSAID's...
April 30, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29707771/nonsteroidal-anti-inflammatory-drug-use-and-breast-cancer-risk-in-a-european-prospective-cohort-study
#5
Manon Cairat, Agnès Fournier, Neil Murphy, Carine Biessy, Augustin Scalbert, Sabina Rinaldi, Anne Tjønneland, Anja Olsen, Kim Overvad, Patrick Arveux, Marie-Christine Boutron-Ruault, Claire Cadeau, Renée Turzanski Fortner, Rudolf Kaaks, Heiner Boeing, Krasimira Aleksandrova, Petra H M Peeters, Carla H Van Gils, Nicholas J Wareham, Kay-Tee Khaw, Dagfinn Aune, Elio Riboli, Marc J Gunter, Laure Dossus
Experimental studies have shown a protective effect of nonsteroidal anti-inflammatory drugs (NSAIDs) on breast cancer development. However, results from epidemiological cohort studies are less consistent. Our objective was to assess the association between NSAID use and breast cancer risk within the European Prospective Investigation into Cancer and Nutrition (EPIC). EPIC is a prospective cohort study initiated in 1992 in 10 European countries. Self-reported information on NSAID use at baseline has been collected in five EPIC countries...
April 29, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29650881/-combination-therapy-of-oxycodone-and-tapentadol-was-effective-for-intractable-pain-caused-by-breast-cancer-bone-metastasis-a-case-report
#6
Tetsuya Matsuura, Akihiko Kusakabe, Takaomi Kessoku, Yasushi Honda, Asuka Yoshimi, Ayumu Goto, Haruhisa Yoshida, Akiko Sukegawa, Atsushi Nakajima, Yasushi Ichikawa
A 52-year-old woman had been prescribed oral medication of acetaminophen, non-steroidal anti-inflammatory drugs (NSAIDs), and oxycodone for intractable pain associated with thoracic metastasis of breast cancer. However, the pain control was poor. Although pregabalin and gabapentin were used as supplementary analgesics, they could not be continued because of their side effects. Based on the noradrenalin reincorporation-inhibiting action of tapentadol, a combination therapy of tapentadol and oxycodone was introduced and satisfactory pain control was achieved...
March 2018: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29571248/anti-inflammatory-and-anti-tumor-effects-of-l-guluronic-acid-g2013-on-cancer-related-inflammation-in-a-murine-breast-cancer-model
#7
Fatemeh Hosseini, Ahmad Mahdian-Shakib, Farhad Jadidi-Niaragh, Seyed Ehsan Enderami, Hamed Mohammadi, Maryam Hemmatzadeh, Hussaini Alhassan Mohammed, Ali Anissian, Parviz Kokhaei, Abbas Mirshafiey, Hadi Hassannia
Cancer-related inflammation (CRI) is associated with the malignant progression of several cancer types. Targeting these pathways is a novel promising strategy for cancer prevention and treatment. In this present study, we evaluated the efficacy of ?-l-guluronic acid (ALG), a potent anti-inflammatory agent on breast cancer-related inflammation both in vitro and in vivo conditions. Our results indicated that ALG can effectively inhibit the CRI and tumor-promoting mediators (COX-2, MMP2, MMP9, VEGF and proinflammatory cytokines) without direct toxic effects on the cells...
February 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29554350/nsaids-to-prevent-breast-cancer-recurrence-an-unanswered-question
#8
Ernest Hawk, Karen Colbert Maresso, Powel Brown
No abstract text is available yet for this article.
March 15, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29553987/chronic-postsurgical-pain-and-cancer-the-catch-of-surviving-the-unsurvivable
#9
Stephen R Humble, Nicolas Varela, Asantha Jayaweera, Arun Bhaskar
PURPOSE OF REVIEW: Chronic postsurgical pain (CPSP) is an important and well recognized cause of much long-term suffering, which in some cases may be preventable and affects many people living with cancer. Unfortunately, general consensus is lacking as to how best reduce the risk of developing CPSP. RECENT FINDINGS: Cancer is now not always a short-lived, fatal disease and is now moving towards a chronic illness. Poorly managed perioperative pain is the greatest risk factor for CPSP...
June 2018: Current Opinion in Supportive and Palliative Care
https://www.readbyqxmd.com/read/29516320/pre-diagnostic-aspirin-use-and-mortality-after-breast-cancer
#10
Tengteng Wang, Humberto Parada, Kathleen M McClain, Patrick T Bradshaw, Mary Beth Terry, Susan L Teitelbaum, Alfred I Neugut, Marilie D Gammon
BACKGROUND: Whether aspirin or other nonsteroidal anti-inflammation drug (NSAID) use is associated with mortality following breast cancer remains unclear. Consideration of use patterns and interaction with obesity may help to clarify the inconsistent results. METHODS: Pre-diagnosis NSAID use, weight, and height were assessed ~ 3 months after diagnosis through in-person interviews with a population-based cohort of 1,442 women with first primary breast cancer...
May 2018: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/29492166/amine-containing-analogs-of-sulindac-for-cancer-prevention
#11
Bini Mathew, Judith V Hobrath, Michele C Connelly, R Kiplin Guy, Robert C Reynolds
Background: Sulindac belongs to the chemically diverse family of Non-Steroidal Anti-Inflammatory Drugs (NSAIDs) that effectively prevent adenomatous colorectal polyps and colon cancer, especially in patients with familial adenomatous polyposis. Sulindac sulfide amide (SSA), an amide analog of sulindac sulfide, shows insignificant COX-related activity and toxicity while enhancing anticancer activity in vitro and demonstrating in vivo xenograft activity. Objective: Develop structure-activity relationships in the sulindac amine series and identify analogs with promising anticancer activities...
2018: Open Medicinal Chemistry Journal
https://www.readbyqxmd.com/read/29412868/aspirin-and-ibuprofen-in-bulk-and-nanoforms-effects-on-dna-damage-in-peripheral-lymphocytes-from-breast-cancer-patients-and-healthy-individuals
#12
Osama Dandah, Mojgan Najafzadeh, Mohammed Isreb, Richard Linforth, Catherine Tait, Adi Baumgartner, Diana Anderson
Regular use of non-steroidal anti-inflammatory drugs (NSAIDs) may be protective against tumours, including breast cancer. We have studied the effects of ibuprofen and aspirin on DNA damage in lymphocytes obtained from breast cancer patients and healthy female controls. Both nanoparticle (NPs) and bulk formulations were used in the comet and micronucleus (MN) assays. Non-toxic doses (250 ng/ml ibuprofen; 500 ng/ml aspirin) were tested. Aspirin, both bulk and nano formulations, significantly reduced DNA damage measured with the comet and micronucleus assays; the nano formulation was more effective...
February 2018: Mutation Research
https://www.readbyqxmd.com/read/29394713/-a-case-report-of-ipsilateral-nipple-skin-recurrence
#13
Mina Waraya, Keiko Hayashi, Sayuri Oshida, Kouichi Yamamoto, Satoshi Hosoya, Takeyoshi Habiro, Madoka Inukai, Yoshimasa Kosaka, Norihiko Sengoku, Masahiko Watanabe
We report our experience with a patient with breast cancer who showed recurrence in the nipple skin 5 years and 10 months after a breast-preserving surgery. The patient was a woman, and was 65-years old at the time of initial surgery. Breast-preserving surgery and axillary lymph-node dissection were performed for left breast cancer. Invasive ductal carcinoma of the breast(pT3N0M0)was triple-negative, and the patient postoperatively received adjuvant chemotherapy. Left breast pain developed 5 years and 6 months after surgery...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29383157/celecoxib-targets-breast-cancer-stem-cells-by-inhibiting-the-synthesis-of-prostaglandin-e-2-and-down-regulating-the-wnt-pathway-activity
#14
Chaolin Huang, Yuanhong Chen, Hang Liu, Jing Yang, Xuejing Song, Junping Zhao, Na He, Chengji J Zhou, Yongping Wang, Changjiang Huang, Qiaoxiang Dong
Pharmacological targeting of breast cancer stem cells (CSCs) is highly promising for the treatment of breast cancer, as the small population of CSCs is responsible for tumor initiation, progression, recurrence and chemo-resistance. Celecoxib is one of the most commonly used non-steroidal anti-inflammatory drugs (NSAIDs), which have chemo-preventive activity against cancers, including breast cancer and colorectal cancer. However, the mechanisms by which NSAIDs exert its cancer prevention effects have yet been completely understood...
December 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/29377693/antibodies-as-carrier-molecules-encapsulating-anti-inflammatory-drugs-inside-herceptine
#15
José Pedro Cerón-Carrasco, Horacio Pérez-Sánchez, José Zúñiga, Alberto Requena
The human epidermal growth factor receptor 2 (HER2) is overexpressed in about a third of breast cancer patients, with a strong involvement of the cyclooxygenase-2 (COX-2) enzyme in the tumor progress. HER2 and COX-2 are consequently potential targets for inhibiting carcionogenesis. Herceptin (trastuzumab) is an antibody that partially blocks HER2-positive cancers at their initial stage. Unfortunately, the overall response rate to the single treatment with this antibody is still modest, and therefore, it needs to be improved by combining several chemotherapeutic agents...
February 22, 2018: Journal of Physical Chemistry. B
https://www.readbyqxmd.com/read/29295697/towards-prevention-of-ovarian-cancer
#16
Aus Tariq Ali
Ovarian cancer is the leading cause of death of all gynaecological cancers. To date, there is no reliable, specific screening procedure for detecting ovarian cancer. The risk factors of ovarian cancer include modifiable and non-modifiable factors. The main goal of the ovarian cancer prevention program is to significantly reduce the risk of development of ovarian cancer and other cancers such as breast and/or peritoneal cancer. The application of non-surgical preventive approaches such as oral contraceptives, parity and breastfeeding has been shown to be highly protective against ovarian cancer development...
January 1, 2018: Current Cancer Drug Targets
https://www.readbyqxmd.com/read/29273074/use-of-prescription-drugs-and-risk-of-postoperative-red-blood-cell-transfusion-in-breast-cancer-patients-a-danish-population-based-cohort-study
#17
Anne Marie L Thomsen, Alma B Pedersen, Nickolaj R Kristensen, Bjarne Kuno Møller, Christian Erikstrup, Peer M Christiansen, Mette Nørgaard, Deirdre Cronin-Fenton
BACKGROUND: Several frequently used prescription drugs may affect bleeding risk. We investigated use of aspirin, nonsteroidal anti-inflammatory drugs (NSAIDs), selective serotonin reuptake inhibitors (SSRIs), and statins and risk of postoperative red blood cell transfusion in breast cancer patients. METHODS: Using Danish population-based registries, we identified a cohort of women who underwent surgery for primary breast cancer (n = 22,238) during 2005-2012 and ascertained their use of aspirin, NSAIDs, SSRIs, and statins...
December 22, 2017: Breast Cancer Research: BCR
https://www.readbyqxmd.com/read/29202630/concurrent-new-drug-prescriptions-and-prognosis-of-early-breast-cancer-studies-using-the-danish-breast-cancer-group-clinical-database
#18
Deirdre Cronin-Fenton, Timothy L Lash, Thomas P Ahern, Per Damkier, Peer Christiansen, Bent Ejlertsen, Henrik T Sørensen
BACKGROUND: Myriad reports suggest that frequently used prescription drugs alter the viability of breast cancer cells in pre-clinical studies. Routine use of these drugs, therefore, may impact breast cancer prognosis, and could have important implications for public health. METHODS: The Danish Breast Cancer Group (DBCG) clinical database provides high-quality prospectively collected data on breast cancer diagnosis, treatment, and routine follow-up for breast cancer recurrence...
January 2018: Acta Oncologica
https://www.readbyqxmd.com/read/29133038/new-metalo-therapeutics-of-nsaids-against-human-breast-cancer-cells
#19
Christina N Banti, Constantina Papatriantafyllopoulou, Anastasios J Tasiopoulos, Sotiris K Hadjikakou
The non steroidal anti-inflammatory drugs (NSAID's)-silver(I) metallodrugs of aspirin (aspH), salicylic acid (salH2 ), naproxen (napH) acid or p-hydrobenzoic acid (pHbzaH) and the mitochondriotropic triphenylarsine (tpAs) with the formulae [Ag(asp)(tpAs)3 ] (1), [Ag(salH)(tpAs)3 ] (2), [Ag(nap)(tpAs)3 ] (3) and {[Ag(pHbza)(tpAs)3 ]∙(dmf)} (4) and [Ag(tpAs)3 (NO3 )] (5) have been synthesized and characterized by m.p., FT-IR, UV-vis and1 H NMR, spectroscopic techniques and X-ray crystallography. The in vitro cytotoxic activity of 1-5 against human breast adenocarcinoma cancer cells: MCF-7 (positive to estrogen receptors (ERs)) and MDA-MB-231 (negative to estrogen receptors (ERs)) was evaluated...
January 1, 2018: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29104411/synthesis-and-preliminary-assessment-of-the-anticancer-and-wnt-%C3%AE-catenin-inhibitory-activity-of-small-amide-libraries-of-fenamates-and-profens
#20
Bini Mathew, Judith V Hobrath, Wenyan Lu, Yonghe Li, Robert C Reynolds
As part of an ongoing program to study the anticancer activity of non-steroidal anti-inflammatory drugs (NSAIDs) through generating diversity libraries of multiple NSAID scaffolds, we synthesized a series of NSAID amide derivatives and screened these sets against three cancer cell lines (prostate, colon and breast) and Wnt/β-catenin signaling. The evaluated amide analog libraries show significant anticancer activity/cell proliferation inhibition, and specific members of the sets show inhibition of Wnt/β-catenin signaling...
2017: Medicinal Chemistry Research
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