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transitive inference

Daniel V Guebel, Néstor V Torres
Motivation: In the brain of elderly-healthy individuals, the effects of sexual dimorphism and those due to normal aging appear overlapped. Discrimination of these two dimensions would powerfully contribute to a better understanding of the etiology of some neurodegenerative diseases, such as "sporadic" Alzheimer. Methods: Following a system biology approach, top-down and bottom-up strategies were combined. First, public transcriptome data corresponding to the transition from adulthood to the aging stage in normal, human hippocampus were analyzed through an optimized microarray post-processing (Q-GDEMAR method) together with a proper experimental design (full factorial analysis)...
2016: Frontiers in Aging Neuroscience
Sean Yiu, Brian Tom
Multistate processes provide a convenient framework when interest lies in characterising the transition intensities between a set of defined states. If, however, there is an unobserved event of interest (not known if and when the event occurs), which when it occurs stops future transitions in the multistate process from occurring, then drawing inference from the joint multistate and event process can be problematic. In health studies, a particular example of this could be resolution, where a resolved patient can no longer experience any further symptoms, and this is explored here for illustration...
October 17, 2016: Statistics in Medicine
Micah Amd, Bryan Roche
According to the literature on emotional dissonance, information that is emotionally incongruous with self-concepts can produce feelings of unease. At a process level, this suggests that embedding such information in newly formed relational structures would have little effect on their a priori emotive properties. Alternatively, an instrumental account of symbolic relations (e.g., Dymond & Roche, 2013) highlights the importance of contextualized stimulus-stimulus relations, where the structure of a relational series is key in determining the function of its elements...
October 13, 2016: Quarterly Journal of Experimental Psychology: QJEP
Maria Muzik, Diana Morelen, Jessica Hruschak, Katherine Lisa Rosenblum, Erika Bocknek, Marjorie Beeghly
BACKGROUND: The postpartum period represents a major transition in the lives of many women, a time when women are at increased risk for the emergence of psychopathology including depression and PTSD. The current study aimed to better understand the unique contributions of clinically significant postpartum depression, PTSD, and comorbid PTSD/depression on mother-infant bonding and observed maternal parenting behaviors (i.e., behavioral sensitivity, negative affect, positive affect) at 6 months postpartum...
October 3, 2016: Journal of Affective Disorders
Zhao Lei, Xiao Dong Chen, Ruben Mercadé-Prieto
N-ethylmaleimide (NEM) was used to verify that no new disulfide crosslinks were formed during the fascinating rheology of the alkali cold-gelation of whey proteins, which show Sol-Gel-Sol transitions with time at pH > 11.5. These dynamic transitions involve the formation and subsequent destruction of non-covalent interactions between soluble whey aggregates. Therefore, incubation of aggregates with NEM was expected not to affect much the rheology. Experiments show that very little additions of NEM, such as 0...
2016: PloS One
Mario Borgwardt, Martin Wilke, Igor Yu Kiyan, Emad F Aziz
Room-temperature ionic liquids (ILs) represent a well-known class of materials exhibiting extremely low vapor pressures and high electrochemical stability. These properties make ILs attractive for various applications requiring UHV conditions. Here, we apply 1-ethyl-3-methylimidazolium trifluoromethanesulfonate [EMIM][TfO] as a solvent to investigate the excited state dynamics of the transition metal complex [Ru(bpy)3](2+) with the use of ultrafast XUV photoelectron spectroscopy. This study is aimed to reveal the effect of the IL environment when the frontier molecular orbitals and the states dynamics of the solute need to be addressed...
October 10, 2016: Physical Chemistry Chemical Physics: PCCP
Dalila Vescovi, Stefan Luding
Simple homogeneous shear flows of frictionless, deformable particles are studied by particle simulations at large shear rates and for differently soft, deformable particles. Particle stiffness sets a time-scale that can be used to scale the physical quantities; thus the dimensionless shear rate, i.e. the inertial number I (inversely proportional to pressure), can alternatively be expressed as inversely proportional to the square root of particle stiffness. Asymptotic scaling relations for the field variables pressure, shear stress and granular temperature are inferred from simulations in both fluid and solid regimes, corresponding to unjammed and jammed conditions...
September 26, 2016: Soft Matter
Andreas V Stier, Nathan P Wilson, Genevieve Clark, Xiaodong Xu, Scott A Crooker
Excitons in atomically-thin semiconductors necessarily lie close to a surface, and therefore their properties are expected to be strongly influenced by the surrounding dielectric environment. However, systematic studies exploring this role are challenging, in part because the most readily accessible exciton parameter -- the exciton's optical transition energy -- is largely \textit{un}affected by the surrounding medium. Here we show that the role of the dielectric environment is revealed through its systematic influence on the \textit{size} of the exciton, which can be directly measured via the diamagnetic shift of the exciton transition in high magnetic fields...
October 10, 2016: Nano Letters
Lin X Chen, Megan L Shelby, Patrick J Lestrange, Nicholas E Jackson, Kristoffer Haldrup, Michael W Mara, Andrew B Stickrath, Diling Zhu, Henrik Lemke, Matthieu Chollet, Brian M Hoffman, Xiaosong Li
This report will describe our recent studies of transition metal complex structural dynamics on the fs and ps time scales using an X-ray free electron laser source, Linac Coherent Light Source (LCLS). Ultrafast XANES spectra at the Ni K-edge of nickel(ii) tetramesitylporphyrin (NiTMP) were measured for optically excited states at a timescale from 100 fs to 50 ps, providing insight into its sub-ps electronic and structural relaxation processes. Importantly, a transient reduced state Ni(i) (π, 3dx(2)-y(2)) electronic state is captured through the interpretation of a short-lived excited state absorption on the low-energy shoulder of the edge, which is aided by the computation of X-ray transitions for postulated excited electronic states...
September 14, 2016: Faraday Discussions
Julio Blas, Teresa Abaurrea, Marcello D'Amico, Francesca Barcellona, Eloy Revilla, Jacinto Román, Martina Carrete
Traffic is often acknowledged as a threat to biodiversity, but its effects have been mostly studied on roads subjected to high traffic intensity. The impact of lower traffic intensity such as those affecting protected areas is generally neglected, but conservation-oriented activities entailing motorized traffic could paradoxically transform suitable habitats into ecological traps. Here we questioned whether roadside-nesting bee-eaters Merops apiaster perceived low traffic intensity as a stressor eliciting risk-avoidance behaviors (alarm calls and flock flushes) and reducing parental care...
2016: PloS One
Josef B G Gluyas, Simon Gückel, Martin Kaupp, Paul J Low
The electronic characteristics of mixed-valence complexes are often inferred from the shape of the inter-valence charge transfer (IVCT) band, which usually falls in the near infrared (NIR) region, and relationships derived from Marcus-Hush theory. These analyses typically assume one single, dominant molecular conformation. The NIR spectra of the prototypical delocalised (Class III Robin-Day mixed-valence) complexes [{Ru(pp)Cp'}2 (μ-C≡C-C≡C)](+) ([1](+) : Cp'=Cp, pp=(PPh3 )2 ; [2](+) : Cp'=Cp, pp=dppe; [3](+) : Cp'=Cp*, pp=dppe) feature a 'two-band' pattern, which complicates band-shape analysis using these traditional methods...
November 2, 2016: Chemistry: a European Journal
Sarah J Ivory, Margaret W Blome, John W King, Michael M McGlue, Julia E Cole, Andrew S Cohen
Long paleoecological records are critical for understanding evolutionary responses to environmental forcing and unparalleled tools for elucidating the mechanisms that lead to the development of regions of high biodiversity. We use a 1.2-My record from Lake Malawi, a textbook example of biological diversification, to document how climate and tectonics have driven ecosystem and evolutionary dynamics. Before ∼800 ka, Lake Malawi was much shallower than today, with higher frequency but much lower amplitude water-level and oxygenation changes...
October 3, 2016: Proceedings of the National Academy of Sciences of the United States of America
Defeng Kuang, Xiaoping Zhang, Shaofang Hua, Wei Dong, Zhiguo Li
Ovarian cancer is the fifth leading cause of cancer-related death in women worldwide, and recent studies have highlighted the role of long non-coding RNAs (lncRNAs) in cancer development. However, the role of lncRNAs in ovarian cancer is largely unclear. In this study, we focused on the taurine up-regulated gene 1 (TUG1) and examined its molecular mechanism in ovarian cancer. Here, we reported that TUG1 was up-regulated in ovarian cancer tissues and ovarian cancer cells, and TUG1 expression was positively correlated with tumor grade and FIGO stage...
September 28, 2016: Experimental and Molecular Pathology
(no author information available yet)
Reports an error in "Temporal Attitudes Profile Transition Among Adolescents: A Longitudinal Examination Using Mover-Stayer Latent Transition Analysis" by Grant B. Morgan, Kevin E. Wells, James R. Andretta and Michael T. McKay (Psychological Assessment, Advanced Online Publication, Sep 5, 2016, np). In the original article, the affiliation for Michael T. McKay should be Department of Psychological Sciences, University of Liverpool. All versions of this article have been corrected. (The following abstract of the original article appeared in record 2016-42727-001...
October 3, 2016: Psychological Assessment
Ran Pang, Li-Juan Yu, Meng Zhang, Zhong-Qun Tian, De-Yin Wu
Strong hydrogen-bonding interaction and Raman spectra of hydrated proton have been investigated using hybrid density functional theory method B3LYP. The solvation model of density (SMD) approach is employed in the present calculation to simulate hydrated protons in aqueous solution. Focusing on the different hydrogen-bonded Eigen-water and Zundel-water interactions, we present a better assignment of Raman signals of hydrated proton on the basis of vibrational analysis in different environments. Our results showed that B3LYP calculations could give a good prediction for characteristic vibrational frequencies of Eigen and Zundel isomers in liquid phase...
October 12, 2016: Journal of Physical Chemistry. A
Mariela Acuña Mora, Philip Moons, Carina Sparud-Lundin, Ewa-Lena Bratt, Eva Goossens
BACKGROUND: Life-long specialized care is of the utmost importance to safeguard longevity as well as the quality of life in children diagnosed with a chronic condition (CC). Provision of life-long care, however, infers transfers to different settings in line with person's development status. Young people with CC (10-25 years) will transfer care from a pediatric towards an adult-oriented care setting. As a transfer of care is associated with a change of care context, healthcare team, responsibilities, expectations, and roles, patients need to be prepared for this alteration...
September 29, 2016: Systematic Reviews
Menahem Yeari, Adi Avramovich, Rachel Schiff
INTRODUCTION: Previous studies have demonstrated that students with attention-deficit/hyperactivity disorder (ADHD) struggle particularly with grasping the implicit, inferential level of narratives that is crucial for story comprehension. However, these studies used offline tasks (i.e., after story presentation), used indirect measurements (e.g., identifying main ideas), and/or yielded inconclusive results using think-aloud techniques. Moreover, most studies were conducted with preschool or elementary school children with ADHD, using listening or televised story comprehension...
September 29, 2016: Journal of Clinical and Experimental Neuropsychology
Antonella De Pasquale, Davide Rossini, Rosario Fazio, Vittorio Giovannetti
Thermodynamics relies on the possibility to describe systems composed of a large number of constituents in terms of few macroscopic variables. Its foundations are rooted into the paradigm of statistical mechanics, where thermal properties originate from averaging procedures which smoothen out local details. While undoubtedly successful, elegant and formally correct, this approach carries over an operational problem, namely determining the precision at which such variables are inferred, when technical/practical limitations restrict our capabilities to local probing...
2016: Nature Communications
Yuanyang Zhang, Tie Bo Wu, Bernie J Daigle, Mitchell Cohen, Linda Petzold
BACKGROUND: Trauma is the leading cause of death between the ages of 1 to 44 in the United States. Blood loss is the primary cause of these deaths. The discrimination of states through which patients transition would be helpful in understanding the disease process, and in identification of critical states and appropriate interventions. Even though these states are strongly associated with patients' blood composition data, there has not been a way to directly identify them. Statistical tools such as hidden Markov models can be used to infer the discrete latent states from the blood composition data...
2016: BMC Medical Informatics and Decision Making
Pingbo Zhang, Min Zhu, Minghui Geng-Spyropoulos, Michelle Shardell, Marta Gonzalez-Freire, Vilmundur Gudnason, Gudny Eiriksdottir, Debra Schaumberg, Jennifer E Van Eyk, Luigi Ferrucci, Richard D Semba
Age-related macular degeneration (AMD) is a leading cause of visual loss among older adults. Two variants in the complement factor H (CFH) gene, Y402H and I62V, are strongly associated with risk of AMD. CFH is encoded in Regulator of Complement Activation gene cluster in chromosome 1q32, which includes complement factor-related (CFHR) proteins, CFHR1 to CFHR5, with high amino acid sequence homology to CFH. Our goal was to build a selected reaction monitoring (SRM) assay to measure plasma concentrations of CFH variants Y402, H402, I62, and V62, and CFHR1-5...
September 20, 2016: Proteomics
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