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Secondary amenorrhea

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https://www.readbyqxmd.com/read/29757049/prevalence-of-indicators-of-low-energy-availability-in-elite-female-sprinters
#1
Jennifer Sygo, Alexandra M Coates, Erik Sesbreno, Margo L Mountjoy, Jamie F Burr
Low energy availability (LEA), and subsequent relative energy deficiency in sport (RED-S), has been observed in endurance, aesthetic, and team sport athletes, with limited data on prevalence in athletes in short-burst activities such as sprinting. We examined prevalence of signs and symptoms of LEA in elite female sprinters at the start of the training season (PRE), and at the end of a 5-month indoor training period (POST). Four of 13 female sprinters (31%) presented at PRE testing with at least one primary (amenorrhea, low BMD, low FSH, LH, or estradiol, RMR ≤ 29kcal/kg FFM, Low Energy Availability in Females Questionnaire (LEAF-Q) score ≥8) and one secondary indicator of LEA (fasting blood glucose < 4mmol/L, free triiodothyronine < 3...
May 14, 2018: International Journal of Sport Nutrition and Exercise Metabolism
https://www.readbyqxmd.com/read/29739679/low-trabecular-bone-score-in-adolescent-female-inpatients-with-anorexia-nervosa
#2
Yael Levy-Shraga, Liana Tripto-Shkolnik, Dana David, Iris Vered, Daniel Stein, Dalit Modan-Moses
BACKGROUND & AIMS: Trabecular bone score (TBS) is an emerging technology that provides information regarding bone microarchitecture. A recent study showed that in healthy girls normal TBS (≥1.35) was achieved within the first year post-menarche. The aims of our study was to assess TBS in adolescents with anorexia nervosa (AN) and to evaluate correlations with clinical, laboratory and densitometric variables. METHODS: A cohort study of 208 adolescent females (mean age 15...
April 26, 2018: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/29657689/successful-management-of-abdominal-pregnancy-two-case-reports
#3
Shabnam Saquib, Wafa Elhussein Mohammed Talha
Abdominal pregnancy is a rare, life-threatening condition defined as pregnancy in the peritoneal cavity exclusive of tubal, ovarian, or intraligamentary locations. It can be primarily located in the peritoneal cavity or secondary to a ruptured ectopic pregnancy or tubal abortion. We present two cases of abdominal pregnancy, one primary and another secondary, both diagnosed and successfully managed in our institution. The first patient, a para 2 at 14 weeks gestation, presented with abdominal pain, distension, and dizziness, which had started four days prior...
March 2018: Oman Medical Journal
https://www.readbyqxmd.com/read/29605411/efficacy-and-safety-of-pulsatile-gonadotropin-releasing-hormone-therapy-among-patients-with-idiopathic-and-functional-hypothalamic-amenorrhea-a-systematic-review-of-the-literature-and-a-meta-analysis
#4
Anastasios Tranoulis, Alexandros Laios, Andreas Pampanos, Drakoulis Yannoukakos, Dimitrios Loutradis, Lina Michala
OBJECTIVE: To systematically review and appraise the existing evidence in relation to the efficacy and safety of pulsatile gonadotropin-releasing hormone (pGnRH) for the treatment of women with hypothalamic amenorrhea (HA). DESIGN: Systematic review and meta-analysis. SETTING: Not applicable. PATIENT(S): A total of 35 studies (three randomized and 32 observational) encompassing 1,002 women with HA. INTERVENTION(S): None...
March 28, 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29601346/low-bone-mineral-density-in-elite-female-athletes-with-a-history-of-secondary-amenorrhea-in-their-teens
#5
Sayaka Nose-Ogura, Osamu Yoshino, Michiko Dohi, Mika Kigawa, Miyuki Harada, Takashi Kawahara, Yutaka Osuga, Shigeru Saito
OBJECTIVE: To determine whether secondary amenorrhea during teenage years influences bone mineral density (BMD) in female athletes in their 20s. DESIGN: Original research. SETTING: Japan Institute of Sports Sciences. PARTICIPANTS: Two hundred ten elite female athletes older than 20 years were included in the study. MAIN OUTCOME MEASURES: Information on the participants' past (ie, during their teenage years) and current menstrual cycle, training time, history of stress fractures, and blood tests for hormones received was obtained...
March 27, 2018: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/29549685/the-traditional-medicine-aspects-biological-activity-and-phytochemistry-of-arnebia-spp
#6
Amirsaeed Hosseini, Fatemeh Mirzaee, Ali Davoodi, Hossein Bakhshi Jouybari, Mohammad Azadbakh
Arnebia, a sub cosmopolitan and important genus of the Boraginaceae family, comprises 25 species distributed among the world. Based on the studies of Persian medicine texts, there are some promising bioactivities for this genus that is unknown in modern medicine and some of them are still the basis of new remedies. This article presents Arnebia according to the most important ancient information by the most famous Persian medicine books like Makhzan Al Advieh, Tohfat Al-Momenin, Al-Qanun, Al-Seidaneh and Ekhtiarate Badiei...
February 1, 2018: Medicinski Glasnik
https://www.readbyqxmd.com/read/29463142/levonorgestrel-emergency-contraceptive-pills-use-during-breastfeeding-effect-on-infants-health-and-development
#7
Omar M Shaaban, Ahmed M Abbas, Hanaa R Mahmoud, Entsar M Yones, Ahmed Mahmoud, Mahmoud S Zakherah
OBJECTIVE: The current study aims to evaluate the effect of the use of single packet of levonorgestrel emergency contraceptive pills (LNG-ECPs) during breastfeeding on the health and development of the nursing infant. MATERIALS AND METHODS: The current study was an ancillary observational cohort study carried out in a university hospital. We counseled all women delivered and planning birth-space and breastfeed for at least 1 year for participation during postpartum hospital stay...
February 20, 2018: Journal of Maternal-fetal & Neonatal Medicine
https://www.readbyqxmd.com/read/29454033/cause-or-coincidence-spontaneous-hematometra-in-young-women-receiving-depomedroxyprogesterone-acetate-a-small-case-series
#8
Julie G Thorne, Elizabeth H Russell, Danielle Rumbolt, Mary Anne Jamieson
BACKGROUND: Abdominal pain, secondary amenorrhea, and abnormal uterine bleeding are common gynecologic presentations in adolescence. Rarely this can be associated with an acquired hematometra. Hematometra is a condition of retained blood or clot within the uterus. High-dose progestogenic agents in this age group have been implicated in the accumulation of a hematometra without other explanation. CASES: We present 4 cases of hematometra after depomedroxyprogesterone acetate (DMPA) therapy in previously menstruating adolescents...
February 14, 2018: Journal of Pediatric and Adolescent Gynecology
https://www.readbyqxmd.com/read/29440927/adrenal-myelolipoma-with-hyperandrogenemia-and-schizophrenia
#9
Ningning Liu, Wenhua Zhang, Jiangshan Tan, Jiaxin Zhou, Xiaopeng Yu, Ningxin Ren, Zhiqing Fang, Wei Jiao, Yidong Fan, Cheng Liu
Adrenal myelolipoma with hyperandrogenemia is extremely rare. We report a case of a 26-year-old Chinese female with schizophrenia, who presented with a hormonally active tumor causing hyperandrogenemia. The mass was found by computerized tomography when she had her gynecologic examination for secondary amenorrhea, and it was confirmed to be an adrenal myelolipoma after a histopathological study. She was referred for a left adrenal laparoscopic excision, and the size of adrenal myelolipoma was found to be more than 10 cm...
2018: Cancer Management and Research
https://www.readbyqxmd.com/read/29430160/a-case-of-primary-amenorrhea-with-swyer-syndrome
#10
Pritti K Priya, Vineet V Mishra, Sumesh Choudhary, Jamal S Rizvi
Swyer syndrome with complete gonadal dysgenesis is associated with an absence of testicular differentiation in a phenotypic female with a 46, XY karyotype. A 14-year-old unmarried girl was referred with complaints of primary amenorrhea and nondevelopment of breast. Her built was normal. Examination of her secondary sexual characteristics revealed no breast development, absent axillary hairs, and sparse pubic hairs. External genitalia was of female type. Karyotype showed genotype of 46, XY. Magnetic resonance imaging revealed hypoplastic uterus with absent fallopian tubes and ovaries...
October 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/29420395/ulipristal-acetate-for-treatment-of-symptomatic-uterine-leiomyomas-a-randomized-controlled-trial
#11
James A Simon, William Catherino, James H Segars, Rick E Blakesley, Anna Chan, Vilma Sniukiene, Ayman Al-Hendy
OBJECTIVE: To assess efficacy and tolerability of ulipristal acetate, a selective progesterone receptor modulator, for treatment of symptomatic uterine leiomyomas. METHODS: This phase 3, double-blind, placebo-controlled study enrolled premenopausal women (aged 18-50 years) with abnormal uterine bleeding, one or more discrete leiomyomas, and uterine size 20 weeks of gestation or less. Patients were randomized 1:1:1 to 5 mg ulipristal, 10 mg ulipristal, or placebo once daily for 12 weeks followed by 12-week drug-free follow-up...
March 2018: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/29415121/mayer-rokitansky-kuster-hauser-syndrome-a-unique-case-presentation
#12
Bao T Nguyen, Katherine L Dengler, Rhiana D Saunders
Background: Mayer-Rokitansky-Kuster-Hauser (MRKH) syndrome is a congenital condition characterized by aplasia of the vagina with or without concurrent uterine and/or cervical aplasia. Type II (MURCS) is a rare form involving MUllerian agenesis, Renal agenesis, and Cervicothoracic Somite anomalies. Case: A 17-yr-old virginal female presented for evaluation of primary amenorrhea and pelvic pain. Her medical history was significant for a bicuspid aortic valve and right radial dysplasia...
February 5, 2018: Military Medicine
https://www.readbyqxmd.com/read/29366348/case-report-an-identical-twin-with-sertoli-leydig-cell-tumor
#13
Kristy Cho, Jon C Havelock, Blake Gilks, Caitlin Dunne
Our report details the workup and management of a 43-year-old woman with an identical twin who presented with 2 years of virilization and secondary amenorrhea. Serum total testosterone was elevated. An MRI did not identify adnexal or adrenal pathology. Subsequent ovarian vein sampling demonstrated unilateral testosterone elevation. The patient underwent laparoscopic unilateral oophorectomy resulting in the diagnosis of Sertoli-Leydig cell tumor (SLCT). Although SLCT is a rare sex-cord ovarian tumor, it is associated with endometrial hyperplasia and malignancy...
January 24, 2018: Gynecological Endocrinology
https://www.readbyqxmd.com/read/29332135/sequential-versus-simultaneous-use-of-chemotherapy-and-gonadotropin-releasing-hormone-agonist-gnrha-among-estrogen-receptor-er-positive-premenopausal-breast-cancer-patients-effects-on-ovarian-function-disease-free-survival-and-overall-survival
#14
Ying Zhang, Yajie Ji, Jianwei Li, Li Lei, Siyu Wu, Wenjia Zuo, Xiaoqing Jia, Yujie Wang, Miao Mo, Na Zhang, Zhenzhou Shen, Jiong Wu, Zhimin Shao, Guangyu Liu
OBJECTIVE: To investigate ovarian function and therapeutic efficacy among estrogen receptor (ER)-positive, premenopausal breast cancer patients treated with gonadotropin-releasing hormone agonist (GnRHa) and chemotherapy simultaneously or sequentially. METHOD: This study was a phase 3, open-label, parallel, randomized controlled trial (NCT01712893). Two hundred sixteen premenopausal patients (under 45 years) diagnosed with invasive ER-positive breast cancer were enrolled from July 2009 to May 2013 and randomized at a 1:1 ratio to receive (neo)adjuvant chemotherapy combined with sequential or simultaneous GnRHa treatment...
April 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29285373/successful-detection-of-sry-gene-via-fine-needle-biopsy-a-case-of-extragenital-gestational-choriocarcinoma-in-the-kidney
#15
Shunsuke Orisaka, Kyosuke Kagami, Yasunari Mizumoto, Wataru Koda, Masanori Ono, Mitsuhiro Nakamura, Hiroshi Fujiwara
The current report describes a case of extragenital gestational choriocarcinoma in the kidney. A 36-year-old woman with a history of two deliveries of male babies visited the present hospital due to secondary amenorrhea following a positive urinary pregnancy test. Despite a high serum level of human chorionic gonadotropin, at 51,800 mIU/ml, diagnostic imaging methods and pathological examination did not detect any conceptus in the genital tract. Positron emission tomography-computed tomography detected18 F-FDG-positive tumors in the left kidney and right lung...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29241916/etiology-and-management-of-primary-amenorrhoea-a-study-of-102-cases-at-tertiary-centre
#16
Alka Kriplani, Manu Goyal, Garima Kachhawa, Reeta Mahey, Vidushi Kulshrestha
OBJECTIVE: To determine the prevalence of etiologic causes of primary amenorrhea in Indian population. MATERIALS AND METHODS: A retrospective study was performed using 102 complete medical records of women with primary amenorrhea who attended the Gynaecologic Endocrinology Clinic, Department of Obstetrics and Gynaecology, AIIMS, New Delhi from September 2012 to September 2015. Cases were analysed according to clinical profile, development of secondary sexual characteristics, physical examination, pelvic and rectal examination, X-ray of chest and lumbo-sacral spine, hormone profile, pelvic USG, MRI, and cytogenetic study including karyotype...
December 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29182666/gnrh-receptor-gene-mutations-in-adolescents-and-young-adults-presenting-with-signs-of-partial-gonadotropin-deficiency
#17
Johanna Hietamäki, Matti Hero, Elina Holopainen, Johanna Känsäkoski, Kirsi Vaaralahti, Anna-Pauliina Iivonen, Päivi J Miettinen, Taneli Raivio
Biallelic, partial loss-of-function mutations in GNRHR cause a wide spectrum of reproductive phenotypes from constitutional delay of growth and puberty to complete congenital hypogonadotropic hypogonadism. We studied the frequency of GNRHR, FGFR1, TAC3, and TACR3 mutations in nine adolescent and young adult females with clinical cues consistent with partial gonadotropin deficiency (stalled puberty, unexplained secondary amenorrhea), and describe phenotypic features and molecular genetic findings of monozygotic twin brothers with stalled puberty...
2017: PloS One
https://www.readbyqxmd.com/read/29117655/genetic-etiology-of-primary-premature-ovarian-insufficiency
#18
REVIEW
Maja Franić-Ivanišević, Damir Franić, Miomira Ivović, Milina Tančić-Gajić, Ljiljana Marina, Marija Barac, Svetlana Vujović
Primary premature ovarian insufficiency (PPOI) is characterized by hypergonadotropic amenorrhea and hypoestrogenism in women under 40 years of age. PPOI incidence is 1:10,000 in women aged 18-25, 1:1000 in women aged 25-30 and 1:100 in women aged 35-40. In 10%-28% of cases, PPOI causes primary and in 4%-18% secondary amenorrhea. The process is a consequence of accelerated oocyte atresia, diminished number of germinated cells, and central nervous system aging. Specific genes are responsible for the control of oocyte number undergoing the ovulation process and the time to cessation of the reproductive function...
December 2016: Acta Clinica Croatica
https://www.readbyqxmd.com/read/29101609/assessment-of-ovarian-function-after-chemotherapy-in-women-with-early-and-locally-advanced-breast-cancer-from-serbia
#19
Emina Malisic, Snezana Susnjar, Jelena Milovanovic, Natasa Todorovic-Rakovic, Vesna Kesic
PURPOSE: Among harmful effects of chemotherapy is the reduction of ovarian function. The aim was to determine the serum levels of FSH, LH, estradiol and AMH after chemotherapy followed by endocrine therapy in breast cancer patients. METHODS: The study included 40 premenopausal hormone receptor-positive breast cancer patients aged 33-50 years. Anthracycline-based chemotherapy received 14/40 while anthracycline-taxane combination received 26/40 of patients, followed by tamoxifen (30/40) or tamoxifen plus goserelin (10/40)...
February 2018: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/29091146/how-polymorphic-markers-contribute-to-genetic-diseases-in-different-populations-the-study-of-inhibin-a-for-premature-ovarian-insufficiency
#20
Denise Maria Christofolini, Emerson Barchi Cordts, Fernando Santos-Pinheiro, Erika Azuma Kayaki, Mayla Cristina Fernandes Dornas, Monise de Castro Santos, Bianca Bianco, Caio Parente Barbosa
OBJECTIVE: To verify the incidence of the G679A mutation in exon 2 of the gene inhibin alpha (INHA), in women with secondary amenorrhea and diagnosis of premature ovarian insufficiency, and in controls. METHODS: A 5mL sample of peripheral blood was collected from all study participants in an EDTA tube and was used for DNA extraction. For the patient group, 5mL of blood were also collected in a tube containing heparin for karyotype, and 5mL were collected in a dry tube for follicle stimulant hormone dosage...
July 2017: Einstein
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