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https://www.readbyqxmd.com/read/29657509/a-tensor-statistical-model-for-quantifying-dynamic-functional-connectivity
#1
Yingying Zhu, Xiaofeng Zhu, Minjeong Kim, Jin Yan, Guorong Wu
Functional connectivity (FC) has been widely investigated in many imaging-based neuroscience and clinical studies. Since functional Magnetic Resonance Image (MRI) signal is just an indirect reflection of brain activity, it is difficult to accurately quantify the FC strength only based on signal correlation. To address this limitation, we propose a learning-based tensor model to derive high sensitivity and specificity connectome biomarkers at the individual level from resting-state fMRI images. First, we propose a learning-based approach to estimate the intrinsic functional connectivity...
June 2017: Information Processing in Medical Imaging: Proceedings of the ... Conference
https://www.readbyqxmd.com/read/29652216/psychophysiological-measures-of-stress-in-caregivers-of-individuals-with-autism-spectrum-disorder-a-systematic-review
#2
Ciara Padden, Carolina Concialdi-McGlynn, Sinead Lydon
PURPOSE: Parents of children with autism spectrum disorder (ASD) often self-report heightened levels of stress and physical health problems. This paper reviewed studies assessing physiological measures of stress among parents of children with ASD. METHODS: Systematic database searches identified 15 studies meeting inclusion criteria. Studies were reviewed to determine: (a) control group characteristics; (b) caregiver and care recipient characteristics; (c) setting; (d) physiological measures employed; (e) physiological outcomes; and (f) stressor type...
April 13, 2018: Developmental Neurorehabilitation
https://www.readbyqxmd.com/read/29644474/risk-factors-for-parental-psychopathology-a-study-in-families-with-children-or-adolescents-with-psychopathology
#3
L W Wesseldijk, G C Dieleman, F J A van Steensel, M Bartels, J J Hudziak, R J L Lindauer, S M Bögels, C M Middeldorp
The parents of children with psychopathology are at increased risk for psychiatric symptoms. To investigate which parents are mostly at risk, we assessed in a clinical sample of families with children with psychopathology, whether parental symptom scores can be predicted by offspring psychiatric diagnoses and other child, parent and family characteristics. Parental depressive, anxiety, avoidant personality, attention-deficit/hyperactivity (ADHD), and antisocial personality symptoms were measured with the Adult Self Report in 1805 mothers and 1361 fathers of 1866 children with a psychiatric diagnosis as assessed in a child and adolescent psychiatric outpatient clinic...
April 11, 2018: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29628271/functional-network-abnormalities-consistent-with-behavioral-profile-in-autism-spectrum-disorder
#4
René Besseling, Rolf Lamerichs, Britt Michels, Stephan Heunis, Anton de Louw, Anton Tijhuis, Jan Bergmans, Bert Aldenkamp
Autism spectrum disorder (ASD) is a neurodevelopmental disorder in which the severity of symptoms varies over subjects. The iCAPs model (innovation-driven co-activation patterns) is a recently developed spatio-temporal model to describe fMRI data. In this study, the iCAPs model was employed to find functional imaging biomarkers for ASD in resting-state fMRI data. MRI data from 125 ASD patients and 243 healthy controls was selected from the online ABIDE data repository. Following standard fMRI preprocessing steps, the iCAP patterns were fitted to the data to obtain network time series...
February 21, 2018: Psychiatry Research
https://www.readbyqxmd.com/read/29619645/parent-expectations-and-preparatory-activities-as-adolescents-with-asd-transition-to-adulthood
#5
Laura G Holmes, Anne V Kirby, Donald S Strassberg, Michael B Himle
Community stakeholders, researchers, and providers are increasingly focused on individual, family, and systemic factors that contribute to positive outcomes for adults on the autism spectrum. Parent expectations for their youth's future are associated with adult outcomes (e.g., employment, school success, independence), yet the mechanism for this effect remains unclear. This study investigated how expectations were related to parent transition-related activities in a sample of 298 parents of adolescents on the autism spectrum (48% female adolescents), stratified by parent-reported IQ (average or above, borderline, or below 70)...
April 4, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29610457/cntnap2-stabilizes-interneuron-dendritic-arbors-through-cask
#6
Ruoqi Gao, Nicolas H Piguel, Alexandria E Melendez-Zaidi, Maria Dolores Martin-de-Saavedra, Sehyoun Yoon, Marc P Forrest, Kristoffer Myczek, Gefei Zhang, Theron A Russell, John G Csernansky, D James Surmeier, Peter Penzes
Contactin associated protein-like 2 (CNTNAP2) has emerged as a prominent susceptibility gene implicated in multiple complex neurodevelopmental disorders, including autism spectrum disorders (ASD), intellectual disability (ID), and schizophrenia (SCZ). The presence of seizure comorbidity in many of these cases, as well as inhibitory neuron dysfunction in Cntnap2 knockout (KO) mice, suggests CNTNAP2 may be crucial for proper inhibitory network function. However, underlying cellular mechanisms are unclear. Here we show that cultured Cntnap2 KO mouse neurons exhibit an inhibitory neuron-specific simplification of the dendritic tree...
April 2, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29610413/transition-of-individuals-with-autism-to-adulthood-a-review-of-qualitative-studies
#7
Kristy A Anderson, Collette Sosnowy, Alice A Kuo, Paul T Shattuck
Many young adults with autism spectrum disorder experience poor transition outcomes in key areas, including postsecondary employment, higher education, health care, social connectedness, and independent living, yet we lack a clear understanding of the specific factors that impact these outcomes. We reviewed qualitative research in which the perspectives of youth and young adults with autism spectrum disorder, parents, services providers, and other stakeholders were gathered to identify barriers and facilitators to optimal outcomes...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29610409/network-measures-of-collaborative-support-for-young-adults-with-autism
#8
Elizabeth McGhee Hassrick, Paul Shattuck, Kathleen Carley
OBJECTIVES: The treatment of autism requires complex, multimodal interventions, provided by parents and providers across settings. As young adults with autism spectrum disorder (ASD) transition into adulthood, new stakeholders are added to support planning for postsecondary employment. In this article, we investigate the use of dynamic social network measures that describe the resources of young adults throughout transition. METHODS: A longitudinal, dynamic social network survey (Social Dynamics of Intervention [SoDI]) was conceptualized, designed, and conducted as a feasibility test, measuring changes in collaboration among parents and school staff members who provided interventions for children with ASD in 2 urban public schools...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29610408/family-characteristics-and-children-s-receipt-of-autism-services-in-low-resourced-families
#9
Elizabeth A Karp, Rebecca Dudovitz, Bergen B Nelson, Wendy Shih, Amanda Gulsrud, Felice Orlich, Costanza Colombi, Alice A Kuo
OBJECTIVES: Parents of children with autism spectrum disorder (ASD) face competing demands when caring for their child and fulfilling family commitments. It remains unknown whether family obligations and parental stress might decrease the use of intervention services for young children with ASD. METHODS: The current study is a secondary analysis of baseline date from a published randomized control trial with 147 low-resourced caregiver-child dyads. Demographic information, data on service use, maternal employment, parent's perception of their child's development, and parental stress were collected for primary caregivers of 2- to 5-year-old children with ASD from 5 sites...
April 2018: Pediatrics
https://www.readbyqxmd.com/read/29609811/the-effect-of-feature-selection-on-multivariate-pattern-analysis-of-structural-brain-mr-images
#10
Ayşe Demirhan
Clinical predictions performed using structural magnetic resonance (MR) images are crucial in neuroimaging studies and can be used as a successful complementary method for clinical decision making. Multivariate pattern analysis (MVPA) is a significant tool that helps correct predictions by exhibiting a compound relationship between disease-related features. In this study, the effectiveness of determining the most relevant features for MVPA of the brain MR images are examined using ReliefF and minimum Redundancy Maximum Relevance (mRMR) algorithms to predict the Alzheimer's disease (AD), schizophrenia, autism, and attention deficit and hyperactivity disorder (ADHD)...
March 2018: Physica Medica: PM
https://www.readbyqxmd.com/read/29602272/connectivity-dynamics-in-typical-development-and-its-relationship-to-autistic-traits-and-autism-spectrum-disorder
#11
Barnaly Rashid, Laura M E Blanken, Ryan L Muetzel, Robyn Miller, Eswar Damaraju, Mohammad R Arbabshirani, Erik B Erhardt, Frank C Verhulst, Aad van der Lugt, Vincent W V Jaddoe, Henning Tiemeier, Tonya White, Vince Calhoun
Recent advances in neuroimaging techniques have provided significant insights into developmental trajectories of human brain function. Characterizations of typical neurodevelopment provide a framework for understanding altered neurodevelopment, including differences in brain function related to developmental disorders and psychopathology. Historically, most functional connectivity studies of typical and atypical development operate under the assumption that connectivity remains static over time. We hypothesized that relaxing stationarity assumptions would reveal novel features of both typical brain development related to children on the autism spectrum...
March 30, 2018: Human Brain Mapping
https://www.readbyqxmd.com/read/29580218/education-and-employment-status-of-adults-with-autism-spectrum-disorders-in-germany-a-cross-sectional-survey
#12
Fabian Frank, Martina Jablotschkin, Tobias Arthen, Andreas Riedel, Thomas Fangmeier, Lars P Hölzel, Ludger Tebartz van Elst
BACKGROUND: Adults with autism spectrum disorders (ASD) experience challenges in participating in the labour market and struggle to achieve and maintain appropriate professional positions, possibly due to impairments of communication and social interaction. Studies have shown high rates of unemployment as well as evidence of inadequate employment. As knowledge on the participation in the German labour market is scarce, the aim of our study was to examine employment status, type of occupation and inadequate employment in a sample of clinically mostly late-diagnosed and most likely not intellectually disabled adults with ASD in Germany...
March 27, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29579089/to-be-understood-transitioning-to-adult-life-for-people-with-autism-spectrum-disorder
#13
Craig Thompson, Sven Bölte, Torbjörn Falkmer, Sonya Girdler
INTRODUCTION: The purpose of this study was to explore the viewpoints of parents of young people with Autism Spectrum Disorder (ASD) in relation to their child's transition to adulthood. METHODS: Data were collected during four structured focus groups with 19 parents of young people with ASD with average to high intellectual capacities. Condensed meaning units were identified and checked during focus groups, and were subsequently linked to the International Classification of Functioning, Disability and Health (ICF)...
2018: PloS One
https://www.readbyqxmd.com/read/29574736/commentary-randomized-controlled-trials-in-autism-spectrum-disorder-state-of-the-field-and-challenges-for-the-future
#14
Emily Simonoff
This issue of the Journal includes two articles summarizing the evidence from clinical trials aimed at improving symptoms of autism. French and Kennedy (Journal of Child Psychology and Psychiatry, 2018, xx, xxxx) systematically review randomized controlled trials (RCTs) aimed at an "early intervention" and focus on trials including children with or at risk of autism under age 6 years. Although no type of intervention were excluded from their review, none of the included 48 RCTs employed pharmacological modalities and the overwhelming majority tested psychological/behavioural interventions aimed at modifying aspects of observed behaviours that are abnormal in children with autism...
April 2018: Journal of Child Psychology and Psychiatry, and Allied Disciplines
https://www.readbyqxmd.com/read/29556445/promoting-social-learning-at-recess-for-children-with-asd-and-related-social-challenges
#15
Lori B Vincent, Daniel Openden, Joseph A Gentry, Lori A Long, Nicole L Matthews
The school playground provides an ideal opportunity for social inclusion; however, children with autism spectrum disorder (ASD) often struggle to engage in appropriate social interactions in this unstructured environment. Thus, they may spend recess time alone. The FRIEND Playground Program is a structured, play-based intervention aimed at improving social interactions of children with ASD and other social challenges during recess. The current research study employed a multiple baseline across participant design to systematically evaluate whether this intervention yields increased social engagement and initiations with peers during recess...
March 2018: Behavior Analysis in Practice
https://www.readbyqxmd.com/read/29551006/brief-report-developmental-trajectories-of-adaptive-behavior-in-children-and-adolescents-with-asd
#16
Allison T Meyer, Patrick S Powell, Nicole Butera, Mark R Klinger, Laura G Klinger
Research suggests that individuals with autism spectrum disorder (ASD) have significant difficulties with adaptive behavior skills including daily living and functional communication skills. Few studies have examined the developmental trajectory of adaptive behavior across childhood and adolescence. The present study examined longitudinal trajectories of adaptive behavior in a community-based clinic sample of 186 individuals with ASD. The overall pattern indicated an initial increase in adaptive behavior during early childhood followed by a plateau in skills during adolescence for individuals of all IQ groups...
March 17, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29549871/autistic-adults-show-preserved-normalisation-of-sensory-responses-in-gaze-processing
#17
Colin J Palmer, Rebecca P Lawson, Shravanti Shankar, Colin W G Clifford, Geraint Rees
Progress in our understanding of autism spectrum disorder (ASD) has recently been sought by characterising how systematic differences in canonical neural computations employed across the sensory cortex might contribute to clinical symptoms in diverse sensory, cognitive, and social domains. A key proposal is that ASD is characterised by reduced divisive normalisation of sensory responses. This provides a bridge between genetic and molecular evidence for an increased ratio of cortical excitation to inhibition in ASD and the functional characteristics of sensory coding that are relevant for understanding perception and behaviour...
February 21, 2018: Cortex; a Journal Devoted to the Study of the Nervous System and Behavior
https://www.readbyqxmd.com/read/29532353/evidence-of-validity-of-the-autism-mental-status-examination-amse-in-a-brazilian-sample
#18
Marlene Pereira Galdino, Luiz Fernando Longuim Pegoraro, Laura Olalla Saad, David Grodberg, Eloisa Helena Rubello Valler Celeri
This study investigated the psychometric properties of the Autism Mental Status Examination (AMSE) in a Brazilian sample of children and adolescents with autism spectrum disorder (ASD). A sample of 260 children and adolescents, comprising 56 (21.5%) females and 204 (78.5%) males, was assessed. The participants were submitted to both the childhood autism rating scale (CARS-BR) and the AMSE. The CARS-BR was used to estimate ASD severity and the cutoff point on the AMSE. Spearman's correlation test was employed to determine the correlation between the AMSE and CARS-BR scales...
March 12, 2018: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29527157/computational-neuropsychology-and-bayesian-inference
#19
REVIEW
Thomas Parr, Geraint Rees, Karl J Friston
Computational theories of brain function have become very influential in neuroscience. They have facilitated the growth of formal approaches to disease, particularly in psychiatric research. In this paper, we provide a narrative review of the body of computational research addressing neuropsychological syndromes, and focus on those that employ Bayesian frameworks. Bayesian approaches to understanding brain function formulate perception and action as inferential processes. These inferences combine 'prior' beliefs with a generative (predictive) model to explain the causes of sensations...
2018: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29516625/anatomy-guided-joint-tissue-segmentation-and-topological-correction-for-6-month-infant-brain-mri-with-risk-of-autism
#20
Li Wang, Gang Li, Ehsan Adeli, Mingxia Liu, Zhengwang Wu, Yu Meng, Weili Lin, Dinggang Shen
Tissue segmentation of infant brain MRIs with risk of autism is critically important for characterizing early brain development and identifying biomarkers. However, it is challenging due to low tissue contrast caused by inherent ongoing myelination and maturation. In particular, at around 6 months of age, the voxel intensities in both gray matter and white matter are within similar ranges, thus leading to the lowest image contrast in the first postnatal year. Previous studies typically employed intensity images and tentatively estimated tissue probabilities to train a sequence of classifiers for tissue segmentation...
March 8, 2018: Human Brain Mapping
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