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https://www.readbyqxmd.com/read/29216915/rheumatoid-arthritis-bone-marrow-environment-supports-th17-response
#1
Ewa Kuca-Warnawin, Weronika Kurowska, Monika Prochorec-Sobieszek, Anna Radzikowska, Tomasz Burakowski, Urszula Skalska, Magdalena Massalska, Magdalena Plebańczyk, Barbara Małdyk-Nowakowska, Iwona Słowińska, Robert Gasik, Włodzimierz Maśliński
BACKGROUND: Rheumatoid arthritis (RA) is a systemic, autoimmune disease leading to joint destruction and ultimately disability. Bone marrow (BM) is an important compartment in RA, where pathological processes from "outside the joint" can occur. IL-17 is a cytokine that exerts proinflammatory effects and participates in the process of bone destruction. It is believed that IL-17 is involved in pathogenesis of RA. However, little is known about the biology of this cytokine in BM. In the present study we investigated Th17-related cytokines in RA BM...
December 8, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29216697/-case-report-total-hip-replacement-in-osteogenesis-imperfecta
#2
T Ferrer-Catasús, A León-García, M Tey-Pons, A L Arenas-Díaz, F Marqués-López
We study, apropos of a case, a total hip arthroplasty in a patient with osteogenesis imperfecta. The characteristics of this disease, such as high risk of fracture and the presence of deformities, make this surgery a challenge for the orthopedic surgeon. In this manuscript, we review for the first time in this indication the preoperative planning and the selection of implants, with special emphasis on measures for the prevention of complications.
July 2017: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/29209491/a-3d-printed-sensor-for-monitoring-biosignals-in-small-animals
#3
Sung-Joon Cho, Donghak Byun, Tai-Seung Nam, Seok-Yong Choi, Byung-Geun Lee, Myeong-Kyu Kim, Sohee Kim
Although additive manufacturing technologies, also known as 3D printing, were first introduced in the 1980s, they have recently gained remarkable popularity owing to decreased costs. 3D printing has already emerged as a viable technology in many industries; in particular, it is a good replacement for microfabrication technology. Microfabrication technology usually requires expensive clean room equipment and skilled engineers; however, 3D printing can reduce both cost and time dramatically. Although 3D printing technology has started to emerge into microfabrication manufacturing and medical applications, it is typically limited to creating mechanical structures such as hip prosthesis or dental implants...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29208013/patients-and-surgeons-provide-endorsement-of-core-domains-for-total-joint-replacement-clinical-trials
#4
Anh Hoang, Susan M Goodman, Iris Y Navarro-Millán, Lisa A Mandl, Mark P Figgie, Mathias P Bostrom, Douglas E Padgett, Peter K Sculco, Alexander S McLawhorn, Jasvinder A Singh
BACKGROUND: Our objective in this study was to examine whether stakeholders further endorse the core domain set proposed by the Outcome Measures in Rheumatology Trials (OMERACT) total joint replacement (TJR) working group. METHODS: We emailed a survey to 3810 hip/knee arthroplasty patients and 49 arthroplasty surgeons at a high-volume arthroplasty center to rate the importance of each core domain (i.e., pain, function, patient satisfaction, revision surgery, adverse events, and death) and two additional domains (i...
December 6, 2017: Arthritis Research & Therapy
https://www.readbyqxmd.com/read/29206792/direct-anterior-hip-replacement-does-not-pose-undue-radiation-exposure-risk-to-the-patient-or-surgeon
#5
David Clinton McNabb, Jason M Jennings, Daniel L Levy, Todd M Miner, Charlie C Yang, Raymond H Kim
BACKGROUND: The fluoroscopically assisted direct anterior approach for total hip arthroplasty has gained interest in recent years. One of the perceived advantages is the use of fluoroscopy to aid in the positioning of implants. The purpose of this study was to measure the radiation entrance surface dose to anatomically important areas of both patients and surgeons during direct anterior approach total hip arthroplasty. METHODS: Radiation dosimetry badges were placed at the sternal notch and pubic symphysis of 50 patients undergoing direct anterior approach total hip arthroplasty...
December 6, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/29204501/academic-productivity-among-fellowship-associated-adult-total-joint-reconstruction-surgeons
#6
Adam Z Khan, Benjamin V Kelley, Ankur D Patel, David R McAllister, Natalie L Leong
Background: The Hirsch index (h-index) is a measure that evaluates both research volume and quality-taking into consideration both publications and citations of a single author. No prior work has evaluated academic productivity and contributions to the literature of adult total joint replacement surgeons. This study uses h-index to benchmark the academic impact and identify characteristics associated with productivity of faculty members at joint replacement fellowships. Methods: Adult reconstruction fellowship programs were obtained via the American Association of Hip and Knee Surgeons website...
December 2017: Arthroplasty Today
https://www.readbyqxmd.com/read/29203035/-perspective-of-the-transition-from-reusable-instruments-to-single-use-ancillary-in-orthopedic-surgery
#7
J Steelandt, T Vaillant, C Duhamel, S Haghighat, J-M Féron, P Paubel, A-L Cordonnier
OBJECTIVES: Since 2009, single-use (SU) ancillaries for total knee arthroplasty (TKA) and total hip arthroplasty (THA) have been marketed to replace reusable ancillaries. The concept is not innovative but their use in orthopedics is still uncommon. An assessment has been done for the use of SU ancillary in Assistance publique-hôpitaux de Paris with the consequences for the patient, the surgeon and the hospital. METHODS: A technical and a clinical review has been done with those devices in 2015...
December 1, 2017: Annales Pharmaceutiques Françaises
https://www.readbyqxmd.com/read/29200355/comparing-the-effects-of-reference-pricing-and-centers-of-excellence-approaches-to-value-based-benefit-design
#8
Hui Zhang, David W Cowling, Matthew Facer
Various health insurance benefit designs based on value-based purchasing have been promoted to steer patients to high-value providers, but little is known about the designs' relative effectiveness and underlying mechanisms. We compared the impact of two designs implemented by the California Public Employees' Retirement System on inpatient hospital total hip or knee replacement: a reference-based pricing design for preferred provider organizations (PPOs) and a centers-of-excellence design for health maintenance organizations (HMOs)...
December 2017: Health Affairs
https://www.readbyqxmd.com/read/29196384/trends-in-joint-replacement-surgery-in-patients-with-rheumatoid-arthritis
#9
Bradley L Young, Shawna L Watson, Jorge L Perez, Gerald McGwin, Jasvinder A Singh, Brent A Ponce
OBJECTIVE: This study analyzed trends in large total joint arthroplasties (TJA) and in the proportion of these procedures performed on patients with rheumatoid arthritis (RA). METHODS: The US Nationwide Inpatient Sample (2002-2012) was used to identify the incidences of total shoulder (TSA), elbow (TEA), knee (TKA), hip (THA), and ankle (TAA) arthroplasty and the proportion of these performed with coexisting RA. RESULTS: The prevalence of RA among patients with TJA increased 3...
December 1, 2017: Journal of Rheumatology
https://www.readbyqxmd.com/read/29195854/hypothermia-in-total-joint-arthroplasty-a-wake-up-call
#10
Jordan B Simpson, Vijai S Thomas, Sabir K Ismaily, Pavel I Muradov, Philip C Noble, Stephen J Incavo
BACKGROUND: Total joint patients are particularly vulnerable to perioperative hypothermia (PH) (combined effects of anesthesia, radiation, and convective heat loss from exposed skin surfaces and cool temperatures in the operating room). There are limited studies on PH in these patients. METHODS: In a retrospective review of 204 patients undergoing primary hip and 179 undergoing primary knee replacement surgeries, time and temperature parameters were collected from the electronic health records from preoperative and postoperative recovery room nursing assessments, intraoperative anesthesia records, and floor nursing notes...
November 8, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29194186/the-impact-of-different-cross-training-modalities-on-performance-and-injury-related-variables-in-high-school-cross-country-runners
#11
Max R Paquette, Shelby A Peel, Ross E Smith, Mark Temme, Jeffrey N Dwyer
There are many different types of aerobic cross-training modalities currently available. It is important to consider the effects that these different modalities have on running performance and injury risks. The purpose of this study was to compare movement quality, running economy and performance, injury-related biomechanical variables and, hip muscle strength before and after training with different cross-training modalities in high school runners. Thirty-one high school male runners trained for four weeks in one of three cross-training modalities, in addition to a running-only (RUN, n=9) group, for which training sessions replaced two easy runs per week: cycling (CYCLE; n=6), indoor elliptical (ELLIP; n=7) and, outdoor elliptical bike (EBIKE; n=9)...
November 29, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29192736/operative-findings-and-complications-associated-with-adjunctive-hip-arthroscopy-in-95-hips-undergoing-periacetabular-osteotomy
#12
Gregory Maxwell Gosey, Michael P Muldoon, Robert M Healey, Richard F Santore
PURPOSE: to report our initial experience with adjunctive hip arthroscopy and periacetabular osteotomy (PAO). METHODS: Retrospective review of patients who underwent PAO and ipsilateral hip arthroscopy between 2003 and 2013. Indications for arthroscopy were mechanical symptoms and/or positive magnetic resonance imaging to suggest intra-articular pathology including chondrolabral lesions, ligamentum teres tears and hypertrophy, and synovitis. Preoperative Tönnis arthritis grades, age, sex, operative findings and treatment, complications, and, if available, hip survival were recorded...
December 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29192730/3-phase-technicium-99m-bone-scanning-in-patients-with-pain-in-the-hip-region-after-cemented-total-hip-replacement-a-multicentre-series-of-100-cases
#13
Daniel S Hill, Soulat Naim, Roy J Powell, Denis Kinsella, Andrew D Toms, Jonathan Howell
INTRODUCTION: The aim of this study was to assess the benefit of a Technetium-99M (HDP) 3-phase bone scan (TPBS) as an additional diagnostic test in the evaluation of pain in the hip region following cemented total hip replacement (THR) surgery. METHODS: A retrospective study over a 24-month period was performed comprising 100 patients investigated with a TPBS. Investigations were summarised and analysed, and were classified as entirely normal, possibly abnormal, and definitely abnormal...
November 21, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29192728/overestimation-of-the-risk-of-revision-with-kaplan-meier-presenting-the-long-term-outcome-of-total-hip-replacement-in-older-patients
#14
Kalliopi Lampropoulou-Adamidou, Theofilos S Karachalios, George Hartofilakidis
INTRODUCTION: The purpose of the present study was (i) to review the long-term outcome of cemented Charnley total hip replacements (THRs) performed by 1 surgeon (GH), 20 to 42 years ago, in patients ≥60 years, using both the Kaplan-Meier (KM) and the cumulative incidence (CI) methods, and (ii) to compare the estimations of the 2 statistical methods. METHODS: We evaluated the outcome of 306 consecutive primary cemented THRs that were performed in 265 patients. The final clinical, radiographic assessment and satisfaction of living patients were also included...
December 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29192727/which-is-the-best-bearing-surface-for-primary-total-hip-replacement-a-new-zealand-joint-registry-study
#15
Paul Sharplin, Michael C Wyatt, Alaistair Rothwell, Chris Frampton, Gary Hooper
INTRODUCTION: We have investigated the revision rates of all bearing surface combinations for primary total hip replacement (THR) registered on the New Zealand Joint Registry (NZJR) to determine which coupling has been the most durable and successful over the last 16 years. METHODS: There were 106,139 primary THRs registered, resulting in 4,960 revisions for any cause. We examined all-cause revision rates, reasons for revision and performed survival analyses. RESULTS: Ceramic-on-highly cross-linked polyethylene (CoPx) had the lowest all-cause revision rate of 0...
December 1, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/29192099/metal-on-metal-hip-replacements-implications-for-general-practice
#16
EDITORIAL
Victoria K Matharu, Gulraj S Matharu
No abstract text is available yet for this article.
December 2017: British Journal of General Practice: the Journal of the Royal College of General Practitioners
https://www.readbyqxmd.com/read/29188590/characteristics-of-cobalt-related-cardiomyopathy-in-metal-hip-implant-patients-an-evaluation-of-15-published-reports
#17
REVIEW
Ernest S Fung, Andrew Monnot, Michael Kovochich, Kenneth M Unice, Brooke E Tvermoes, David Galbraith, Brent L Finley, Dennis J Paustenbach
Over 300,000 hip replacements occurred in the USA in 2010, and the frequency is likely increasing annually. Blood Cobalt (Co) concentrations in patients with well-functioning cobalt-chromium (Co-Cr) hip implants are usually elevated above background concentrations relative to the general population. Excessive Co exposure, in rare cases, can result in cardiomyopathy. The purpose of this review was to identify cases of cardiomyopathy in metal-containing hip implant patients and to evaluate the possible cause of each patient's cardiomyopathy...
November 29, 2017: Cardiovascular Toxicology
https://www.readbyqxmd.com/read/29188174/diagnosis-of-persistent-infection-in-prosthetic-two-stage-exchange-pcr-analysis-of-sonication-fluid-from-bone-cement-spacers
#18
Sandrine Mariaux, Ulrika Furustrand Tafin, Olivier Borens
Introduction: When treating periprosthetic joint infections with a two-stage procedure, antibiotic-impregnated spacers are used in the interval between removal of prosthesis and reimplantation. According to our experience, cultures of sonicated spacers are most often negative. The objective of our study was to investigate whether PCR analysis would improve the detection of bacteria in the spacer sonication fluid. Methods: A prospective monocentric study was performed from September 2014 to January 2016. Inclusion criteria were two-stage procedure for prosthetic infection and agreement of the patient to participate in the study...
2017: Journal of Bone and Joint Infection
https://www.readbyqxmd.com/read/29186945/correlation-between-gamma-glutamyltransferase-fractions-and-bone-quality
#19
M Franzini, A Nesti, D Panetta, V Fierabracci, S Marchetti, P D Parchi, L Caponi, A Paolicchi, V Musetti, P Salvadori, M Edmin, A Pucci, E Bonicoli, M Scaglione, N Piolanti
Gamma-glutamyltransferase (GGT) has been recently identified as a bone-resorbing factor. The aim of this study was to investigate the association between plasma GGT fractions levels and bone quality. Plasma GGT fractions were analysed by gel-filtration chromatography. Bone quality was established quantitatively by two micro-CT derived microarchitectural parameters: the BV/TV (mineralised bone volume/total volume), and the SMI (structure model index) that describes the rod-like (low resistant) or plate-like (high-resistant) shape of bone trabeculae...
October 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/29185279/metal-on-metal-hip-replacement-mri-signal-intensities-of-different-body-tissues-and-their-relations-to-blood-metal-ion-levels
#20
Einat Slonimsky, Tammar Kushnir, Assaf Kadar, Aharon Menahem, Alon Grundshtein, Steven Velekes, Merav Lidar, Shmuel Dekel, Iris Eshed
BACKGROUND: Metal-on-metal total hip prostheses (MoM-THR) have been shown to produce hypersensitivity reactions and fluid collection (pseudotumor) by the hip as well as high blood metal ions levels (BMILs). OBJECTIVES: To evaluate the magnetic resonance imaging (MRI) signal-to-noise ratio (S/N) in selected body tissues around the hip of patients who underwent MoM hip replacement and to correlate to BMILs. METHODS: Sixty-one MRI hip examinations in 54 post-MoM-THR patients (18 males, 36 females, mean age 65 years) were retrospectively evaluated independently by two readers...
November 2017: Israel Medical Association Journal: IMAJ
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