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https://www.readbyqxmd.com/read/29440064/follow-up-for-patients-with-metal-on-metal-hip-replacements-are-the-new-mhra-recommendations-justified
#1
Gulraj S Matharu, Andrew Judge, Hemant G Pandit, David W Murray
No abstract text is available yet for this article.
February 13, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29436472/a-novel-variant-in-glis3-is-associated-with-osteoarthritis
#2
Elisabetta Casalone, Ioanna Tachmazidou, Eleni Zengini, Konstantinos Hatzikotoulas, Sophie Hackinger, Daniel Suveges, Julia Steinberg, Nigel William Rayner, arcOGEN Consortium, Jeremy Mark Wilkinson, Kalliope Panoutsopoulou, Eleftheria Zeggini
OBJECTIVES: Osteoarthritis (OA) is a complex disease, but its genetic aetiology remains poorly characterised. To identify novel susceptibility loci for OA, we carried out a genome-wide association study (GWAS) in individuals from the largest UK-based OA collections to date. METHODS: We carried out a discovery GWAS in 5414 OA individuals with knee and/or hip total joint replacement (TJR) and 9939 population-based controls. We followed-up prioritised variants in OA subjects from the interim release of the UK Biobank resource (up to 12 658 cases and 50 898 controls) and our lead finding in operated OA subjects from the full release of UK Biobank (17 894 cases and 89 470 controls)...
February 7, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29435896/readmission-rates-and-diagnoses-following-total-hip-replacement-in-relation-to-insurance-payer-status-race-and-ethnicity-and-income-status
#3
Robert S White, Dahniel L Sastow, Licia K Gaber-Baylis, Virginia Tangel, Andrew D Fisher, Zachary A Turnbull
BACKGROUND: Total hip replacements (THRs) are the sixth most common surgical procedure performed in the USA. Readmission rates are estimated at between 4.0 and 10.9%, and mean costs are between $10,000 and $19,000. Readmissions are influenced by the quality of care received. We sought to examine differences in readmissions by insurance payer, race and ethnicity, and income status. METHODS: We analyzed all THRs from 2007 to 2011 in California, Florida, and New York from the State Inpatient Databases, Healthcare Cost and Utilization Project, Agency for Healthcare Research and Quality...
February 12, 2018: Journal of Racial and Ethnic Health Disparities
https://www.readbyqxmd.com/read/29435622/high-bacterial-contamination-rate-of-electrocautery-tips-during-total-hip-and-knee-arthroplasty
#4
Hussein Abdelaziz, Akos Zahar, Christian Lausmann, Thorsten Gehrke, Helmut Fickenscher, Eduardo M Suero, Matthias Gebauer, Mustafa Citak
PURPOSE: The aim of the study was to quantify the bacterial contamination rate of electrocautery tips during primary total joint replacement (TJR), as well as during aseptic and septic revision TJR. METHODS: A total of 150 electrocautery tips were collected between April and July 2017. TJR surgeries were divided into three groups: (1) primary, (2) aseptic and (3) septic revisions. In each group, a total of 50 electrocautery tips were collected. A monopolar electrocautery with a reusable stainless-steel blade tip was used in all cases...
February 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29434715/relationship-between-osteoporosis-and-expression-of-bcl-2-and-cxcl12
#5
Tongtao Pang, Mingzhi Gong, Jiangtao Han, Dan Liu
The changes of expression of anti-apoptotic factor B-cell lymphoma 2 (Bcl-2) and chemokine C-X-C motif ligand 12 (CXCL12) in the pathological process of osteoporosis (OP) were investigated, to provide new ideas for the diagnosis and treatment of OP. A total of 60 postmenopausal women who needed to undergo hip replacement surgery were enrolled and divided into osteoporosis group (OP, n=32) and control group (CK, n=28) according to the results of dual-energy X-ray bone density measure; after operation, cancellousbone from the femoral head or femoral neck was removed, and osteoblasts and osteoclasts were isolated and cultured in vitro...
February 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29432270/what-is-the-long-term-survival-for-primary-tha-with-small-head-metal-on-metal-bearings
#6
Richard de Steiger, Andrea Peng, Peter Lewis, Stephen Graves
BACKGROUND: Large-head metal-on-metal (MoM) bearing hip replacements have been shown to have a much higher rate of revision than other bearing surfaces. However, small-head (≤ 32 mm) MoM bearing surfaces have been in use for many years with several reports of satisfactory mid- to long-term survivorship. It is unclear whether the long-term survival of small-head MoM devices will continue to be satisfactory or whether the same concerns seen with the large-head MoM devices will ultimately become more prevalent...
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29432264/longitudinal-growth-and-pqct-measures-in-hutterite-children-and-grandchildren-are-associated-with-prevalence-of-hip-or-knee-replacement-resulting-from-osteoarthritis-in-parents-and-grandparents
#7
Lee Weidauer, Tianna Beare, Teresa Binkley, Maggie Minett, Bonny Specker
BACKGROUND: Osteoarthritis (OA) is one of the leading causes of disability in the world. Several genes are associated with the development of OA, and previous studies have shown adult children of individuals with OA have higher areal bone mineral density (BMD). Because childhood is an important period of growth and bone development, and body composition is known to be associated with BMD, we speculated that there may be differences in growth and bone measures among young children with a genetic predisposition to OA...
February 8, 2018: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/29431491/customizable-pre-printed-consent-forms-a-solution-in-light-of-the-montgomery-ruling
#8
Deborah Owen, Nick Aresti, Alex Mulligan, Dennis Kosuge
INTRODUCTION: This article presents an audit cycle supported quality improvement project addressing best practice in the consent process for lower limb arthroplasty which takes into account the new standard in surgical consent and the importance of material risks. METHODS: 50 consecutive total hip and total knee replacement consent forms over a 3-month period were reviewed for legibility and completeness. Following the introduction of a new, pre-printed but customizable consent form the review process was repeated...
February 2, 2018: British Journal of Hospital Medicine
https://www.readbyqxmd.com/read/29430492/a-single-femoral-component-for-all-total-hip-replacements-performed-by-a-trust-does-this-affect-early-clinical-and-radiological-outcomes
#9
James Ricketts, Paul Sherry
Background: Hospitals may be under pressure to implement cost saving strategies regarding prosthesis choice. This may involve the use of components which are not the first preference of individual surgeons, or those they have little experience with. We aim to examine the effect of standardizing the type of femoral stem used in a single trust, and determine whether this is safe practice, particularly in those who have never used this particular stem before. Methods: We report results at 2 years of 151 primary total hip arthroplasties performed using a single femoral stem...
January 2018: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/29429942/pooled-human-serum-a-new-culture-supplement-for-bioreactor-based-cell-therapies-preliminary-results
#10
Sara Savelli, Luisa Trombi, Delfo D'Alessandro, Stefania Moscato, Simone Pacini, Simone Lapi, Fabrizio Scatena, Stefano Giannotti, Mario Petrini
BACKGROUND AIMS: Bone marrow mesenchymal stromal cells (MSCs) are an appealing source for several cell-based therapies. Many bioreactors, such as the Quantum Cell Expansion System, have been developed to generate a large number of MSCs under Good Manufacturing Practice conditions by using human platelet lysate (HPL). Previously, we isolated a novel cell population in human bone marrow, mesodermal progenitor cells (MPCs), which we identified as precursors of MSCs. MPCs may represent an important cell source for regenerative medicine applications...
February 8, 2018: Cytotherapy
https://www.readbyqxmd.com/read/29429889/comparison-with-the-osteoconductivity-and-bone-bonding-ability-of-the-iodine-supported-titanium-titanium-with-porous-oxide-layer-and-the-titanium-alloy-in-the-rabbit-model
#11
Tadashi Taga, Tamon Kabata, Yoshitomo Kajino, Daisuke Inoue, Takaaki Ohmori, Takashi Yamamoto, Tomoharu Takagi, Hiroyuki Tsuchiya
BACKGROUND: One of the serious postoperative complications associated with joint replacement is bacterial infection. In our recent investigations, iodine supported titanium implants demonstrated antibacterial activity in both in vitro and in vivo studies. The surfaces of the implants have porous anodic oxide layer with the antiseptic properties of iodine. According to the literature the titanium with porous anodic oxide have good osteoconductivity. But it is not clear whether the properties of iodine influence bone bonding of implants...
February 8, 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29428465/survival-rate-of-short-stem-hip-prostheses-a-comparative-analysis-of-clinical-studies-and-national-arthroplasty-registers
#12
Georg Hauer, Ines Vielgut, Florian Amerstorfer, Werner Maurer-Ertl, Andreas Leithner, Patrick Sadoghi
BACKGROUND: The primary aim was to evaluate the outcome of short-stem hip prostheses in terms of overall revision rates. Data were taken from published literature and national arthroplasty registers. The second study aim was to evaluate a potentially superior outcome of dependent compared to independent clinical studies. METHODS: All clinical studies on short-stem hip prostheses between 2006 and 2016 were reviewed and evaluated with a special interest on revision rates...
February 3, 2018: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29428222/cost-utility-analysis-in-orthopaedic-trauma-what-pays-a-systematic-review
#13
S Coyle, S Kinsella, B Lenehan, J M Queally
BACKGROUND: As healthcare systems come under ever-increasing pressure to provide more care with fewer resources, emphasis is being placed on value-based systems that maximise quality and minimize cost. The aim of this study was to determine which interventions in fracture care have been demonstrated to be cost effective. METHODS: A systemic review of cost-utility studies on the management of fractures from 1976 to 2015 was carried out using a search of the Cost-Effectiveness Analysis Registry, National Health Service Economic Evaluation Database (NHS EED) and MEDLINE...
January 31, 2018: Injury
https://www.readbyqxmd.com/read/29427750/is-dynamic-locking-plate-targon-fn-a-better-choice-for-treating-of-intracapsular-hip-fracture-a-meta-analysis
#14
REVIEW
Hao Yin, Zhengjun Pan, Hua Jiang
PURPOSE: The aim of this study was to assess the outcomes of dynamic locking plate (Targon FN) and other alternative implant (cannulated cancellous screws or sliding hip screw) for treating of intracapsular hip fracture. METHODS: Relevant clinical trials on the dynamic locking plate and alternative implant treatment for intracapsular hip fracture were retrieved through searching the databases, PubMed, Embase and the Cochrane Central Register of Controlled Trials up to August 2017...
February 7, 2018: International Journal of Surgery
https://www.readbyqxmd.com/read/29426007/how-do-patients-trade-off-surgeon-choice-and-waiting-times-for-total-joint-replacement-a-discrete-choice-experiment
#15
Deborah A Marshall, Ken Deal, Barbara Conner-Spady, Eric Bohm, Gillian Hawker, Lynda Loucks, Karen V MacDonald, Tom Noseworthy
OBJECTIVE: Patients face significant waiting times for hip and knee total joint replacement (TJR) in publicly funded healthcare systems. We aimed to assess how surgeon selection and reputation affect patients' willingness to wait for TJR. DESIGN: We assessed patient preferences using a discrete choice experiment questionnaire with 12 choice scenarios administered to patients referred for TJR. Based on qualitative research, pre- and pilot-testing, we characterized each scenario by five attributes: surgeon reputation, surgeon selection, waiting time to surgeon visit (initial consultation), waiting time to surgery, and travel time to hospital...
February 6, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29424145/-mid-term-follow-up-study-of-hip-arthroplasty-for-internal-fixation-failure-of-femoral-intertrochanteric-fractures-in-the-elderly
#16
Qi-Cai Sun, Xuan-Liang Ru, Zhi-Gang Qian, Li-Dong Wu, Shi-Gui Yan, Xiang-Hua Wang
OBJECTIVE: To retrospective analysis the mid-term follow-up effect of hip joint replacement in elderly patients with failure of intertrochanteric fractures of the hip joint internal fixation. METHODS: From December 2008 to December 2011, 32 elderly patients underwent arthroplasty after intertrochanteric fracture fixation failure, of which, 4 death cases were excluded from the study, and the remaining 28 cases were in the study group. The age of patients ranged from 69 to 83 years old with a mean of 75 years old...
July 25, 2017: Zhongguo Gu Shang, China Journal of Orthopaedics and Traumatology
https://www.readbyqxmd.com/read/29424129/micro-perfusion-and-quantitative-analysis-of-the-femoral-head-intraosseous-artery
#17
Xing Qiu, Liang-Liang Cheng, Ben-Jie Wang, Bao-Yi Liu, Lei Yang, Mingyang Yu, Guishan Gu, De-Wei Zhao
The present study investigates the feasibility of micro perfusion of femoral head specimens from femoral neck fracture patients by the inferior retinacular arteries and performing intraosseous artery quantitative analysis of the femoral head. Twelve femoral neck fracture patients who had undergone conventional hip replacement surgery were included in this study. Femoral head specimen arteries were first dissected and exposed and then perfused by the inferior retinacular arteries and all the femoral heads underwent micro-CT scanning...
February 9, 2018: Orthopaedic Surgery
https://www.readbyqxmd.com/read/29423757/comparing-the-validity-and-responsiveness-of-the-eq-5d-5l-to-the-oxford-hip-and-knee-scores-and-sf-12-in-osteoarthritis-patients-1-year-following-total-joint-replacement
#18
Barbara L Conner-Spady, Deborah A Marshall, Eric Bohm, Michael J Dunbar, Tom W Noseworthy
PURPOSE: (1) To assess responsiveness of the EQ-5D-5L compared to Oxford hip and knee scores and the SF-12 in osteoarthritis patients undergoing total hip (THR) or knee (TKR) replacement surgery; (2) to compare distribution and anchor-based methods of assessing responsiveness. METHODS: Questionnaires were mailed to consecutive patients following surgeon referral for primary THR or TKR and 1 year post-surgery. We assessed effect size (ES), standardized response mean (SRM), and standard error of measurement (SEM)...
February 8, 2018: Quality of Life Research
https://www.readbyqxmd.com/read/29422350/the-ideal-total-hip-replacement-bearing-surface-in-the-young-patient-%C3%A2-a-prospective-randomized-trial-comparing-alumina-ceramic-on-ceramic-with-ceramic-on-conventional-polyethylene-15-year-follow-up
#19
Amit Atrey, Jesse I Wolfstadt, Nasir Hussain, Amir Khoshbin, Sarah Ward, Emil H Schemitsch, James P Waddell
BACKGROUND: The optimum bearing surface for total hip arthroplasty remains debatable. We have previously published our outcome at 10 years and this represents the 15-year follow-up. METHODS: A total of 58 hips (in 57 patients with a mean age of 42 years) were randomized to receive either ceramic-on-ceramic (CoC) or ceramic-on-polyethylene (CoP) total hip arthroplasty. We prospectively followed for survivorship, functional outcomes (using the Harris Hip Score and the St Michael's Hip Score [SMH]), and radiological outcomes...
December 6, 2017: Journal of Arthroplasty
https://www.readbyqxmd.com/read/29419677/risk-of-major-comorbidities-among-workers-with-hemophilia-a-14-year-population-based-study
#20
Wei-Min Chu, Hsin-En Ho, Jiaan-Der Wang, Wei-Cheng Chan, Yi-Sheng Liou, Wen-Chao Ho, Sung-Yuan Hu, Yu-Tse Tsan
Multiple comorbidities, especially musculoskeletal dysfunction and cerebrovascular disease, remain barriers to normal social participation among persons with hemophilia (PWH). However, the relative health effects of such comorbidities on workers with hemophilia have seldom been explored. In this study, we investigated the incidence of comorbidities and their risk factors among workers with hemophilia.The study compared the incidence and risk factors of the major comorbidities of 411 workers with hemophilia enrolled in Taiwan's National Health Insurance Research Database between 1997 and 2010 with an age- and sex-matched general population...
February 2018: Medicine (Baltimore)
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