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Autism AND Swimming

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https://www.readbyqxmd.com/read/28948999/16p11-2-deletion-syndrome-mice-perseverate-with-active-coping-response-to-acute-stress-rescue-by-blocking-5-ht2a-receptors
#1
Chris M Panzini, Daniel G Ehlinger, Adele M Alchahin, Yueping Guo, Kathryn G Commons
In humans a chromosomal hemideletion of the 16p11.2 region results in variable neurodevelopmental deficits including developmental delay, intellectual disability and features of autism spectrum disorder (ASD). Serotonin is implicated in ASD but its role remains enigmatic. In this study we sought to determine if and how abnormalities in serotonin neurotransmission could contribute to the behavioral phenotype of the 16p11.2 deletion syndrome in a mouse model (Del mouse). Since ASD is frequently associated with altered response to acute stress and stress may exacerbate repetitive behavior in ASD, we studied the Del mouse behavior in the context of an acute stress using the forced swim test, a paradigm well characterized with respect to serotonin...
September 26, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28921675/altered-cav1-2-function-in-the-timothy-syndrome-mouse-model-produces-ascending-serotonergic-abnormalities
#2
Daniel G Ehlinger, Kathryn G Commons
Polymorphism in the gene CACNA1C, encoding the pore-forming subunit of Cav1.2 L-type calcium channels, has one of the strongest genetic linkages to schizophrenia, bipolar disorder and major depressive disorder: psychopathologies in which serotonin signaling has been implicated. Additionally, a gain-of-function mutation in CACNA1C is responsible for the neurodevelopmental disorder Timothy syndrome that presents with prominent behavioral features on the autism spectrum. Given an emerging role for serotonin in the etiology of autism spectrum disorders (ASD), we investigate the relationship between Cav1...
October 2017: European Journal of Neuroscience
https://www.readbyqxmd.com/read/28864911/the-effectiveness-of-aquatic-group-therapy-for-improving-water-safety-and-social-interactions-in-children-with-autism-spectrum-disorder-a-pilot-program
#3
Michele L Alaniz, Sheila S Rosenberg, Nicole R Beard, Emily R Rosario
Drowning is the number one cause of accidental death in children with Autism Spectrum Disorder (ASD). Few studies have examined the effectiveness of swim instruction for improving water safety skills in children with moderate to severe ASD. This study examines the feasibility and effectiveness of an aquatic therapy program on water safety and social skills in children with mild to severe ASD (n = 7). Water safety skills were evaluated using the Aquatics Skills Checklist and social skills were measured using the Social Skills Improvement Scale...
September 1, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/28647593/features-of-emotional-and-social-behavioral-phenotypes-of-calsyntenin2-knockout-mice
#4
S V Ranneva, K S Pavlov, A V Gromova, T G Amstislavskaya, T V Lipina
Calsyntenin-2 (Clstn2) is the synaptic protein that belongs to the super family of cadherins, playing an important role in learning and memory. We recently reported that Clstn2 knockout mice (Clstn2-KO) have a deficit of GABAergic interneurons coupled with hyperactivity and deficient spatial memory. Given, that impaired functioning of GABA receptors is linked to several psychopathologies, including anxiety and autism, we sought to further characterize Clstn2-KO mice with respect to emotional and social behavior...
June 21, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28287253/the-rodent-forced-swim-test-measures-stress-coping-strategy-not-depression-like-behavior
#5
Kathryn G Commons, Aram B Cholanians, Jessica A Babb, Daniel G Ehlinger
The forced swim test (FST) measures coping strategy to an acute inescapable stress and thus provides unique insight into the neural limb of the stress response. Stress, particularly chronic stress, is a contributing factor to depression in humans and depression is associated with altered response to stress. In addition, drugs that are effective antidepressants in humans typically promote active coping strategy in the FST. As a consequence, passive coping in the FST has become loosely equated with depression and is often referred to as "depression-like" behavior...
May 17, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28025742/loss-of-function-of-ptpr-%C3%AE-and-%C3%AE-observed-in-sporadic-schizophrenia-causes-brain-region-specific-deregulation-of-monoamine-levels-and-altered-behavior-in-mice
#6
Arnaud Cressant, Veronique Dubreuil, Jing Kong, Thorsten Manfred Kranz, Francoise Lazarini, Jean-Marie Launay, Jacques Callebert, Jan Sap, Dolores Malaspina, Sylvie Granon, Sheila Harroch
RATIONALE: The receptor protein tyrosine phosphatase PTPRG has been genetically associated with psychiatric disorders and is a ligand for members of the contactin family, which are themselves linked to autism spectrum disorders. OBJECTIVE: Based on our finding of a phosphatase-null de novo mutation in PTPRG associated with a case of sporadic schizophrenia, we used PTPRG knockout (KO) mice to model the effect of a loss-of-function mutation. We compared the results with loss-of-function in its close paralogue PTPRZ, previously associated with schizophrenia...
February 2017: Psychopharmacology
https://www.readbyqxmd.com/read/27591973/perinatal-exposure-to-the-selective-serotonin-reuptake-inhibitor-citalopram-alters-spatial-learning-and-memory-anxiety-depression-and-startle-in-sprague-dawley-rats
#7
Jenna L N Sprowles, Jillian R Hufgard, Arnold Gutierrez, Rebecca A Bailey, Sarah A Jablonski, Michael T Williams, Charles V Vorhees
Selective serotonin reuptake inhibitors (SSRIs) block the serotonin (5-HT) reuptake transporter (SERT) and increase synaptic 5-HT. 5-HT is also important in brain development; hence when SSRIs are taken during pregnancy there exists the potential for these drugs to affect CNS ontogeny. Prenatal SSRI exposure has been associated with an increased prevalence of autism spectrum disorder (ASD), and peripheral 5-HT is elevated in some ASD patients. Perinatal SSRI exposure in rodents has been associated with increased depression and anxiety-like behavior, decreased sociability, and impaired learning in the offspring, behaviors often seen in ASD...
November 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/27573365/maternal-exposure-to-the-water-soluble-fraction-of-crude-oil-lead-and-their-mixture-induces-autism-like-behavioral-deficits-in-zebrafish-danio-rerio-larvae
#8
Yuanchuan Wang, Hongxiu Zhong, Chonggang Wang, Dongxu Gao, Yulin Zhou, Zhenghong Zuo
Autism spectrum disorder (ASD) is a serious debilitating mental illness with complex symptoms and multi-factorial pathogenesis. Although the pathogenesis of ASD remains unclear, etiology is thought to involve complex, multigenic interactions and possible environmental contributions. In the present study, we used zebrafish (Danio rerio) as a model to investigate whether maternal exposure to the water soluble fraction of crude oil (WSF, 5μg/L), lead (Pb, 20μg/L) and their mixture (5 μg/L WSF+20 μg/L Pb) could induce autism-like behavior in larvae...
August 26, 2016: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/27548863/sensory-patterns-obesity-and-physical-activity-participation-of-children-with-autism-spectrum-disorder
#9
Lisa Mische Lawson, Lauren Foster
Obesity is a public health concern for the population in general and for children with autism spectrum disorder (ASD) specifically. The purpose of this study was to understand relationships between sensory patterns, obesity, and physical activity engagement of children with ASD (N = 77) sampled from a specialized community-based swimming program. This retrospective correlational study analyzed program data. Results show that almost half (42.2%) of the children were overweight or obese, and sensory avoiding behaviors were related to higher body mass index (BMI)...
September 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
https://www.readbyqxmd.com/read/27503008/fragile-x-mental-retardation-protein-knockdown-in-the-developing-xenopus-tadpole-optic-tectum-results-in-enhanced-feedforward-inhibition-and-behavioral-deficits
#10
Torrey L S Truszkowski, Eric J James, Mashfiq Hasan, Tyler J Wishard, Zhenyu Liu, Kara G Pratt, Hollis T Cline, Carlos D Aizenman
BACKGROUND: Fragile X Syndrome is the leading monogenetic cause of autism and most common form of intellectual disability. Previous studies have implicated changes in dendritic spine architecture as the primary result of loss of Fragile X Mental Retardation Protein (FMRP), but recent work has shown that neural proliferation is decreased and cell death is increased with either loss of FMRP or overexpression of FMRP. The purpose of this study was to investigate the effects of loss of FMRP on behavior and cellular activity...
August 8, 2016: Neural Development
https://www.readbyqxmd.com/read/26823546/a-systematic-review-of-the-behavioural-outcomes-following-exercise-interventions-for-children-and-youth-with-autism-spectrum-disorder
#11
REVIEW
Emily Bremer, Michael Crozier, Meghann Lloyd
The purpose of this review was to systematically search and critically analyse the literature pertaining to behavioural outcomes of exercise interventions for individuals with autism spectrum disorder aged ⩽16 years. This systematic review employed a comprehensive peer-reviewed search strategy, two-stage screening process and rigorous critical appraisal, which resulted in the inclusion of 13 studies. Results demonstrated that exercise interventions consisting individually of jogging, horseback riding, martial arts, swimming or yoga/dance can result in improvements to numerous behavioural outcomes including stereotypic behaviours, social-emotional functioning, cognition and attention...
November 2016: Autism: the International Journal of Research and Practice
https://www.readbyqxmd.com/read/26210514/leisure-activity-enjoyment-of-children-with-autism-spectrum-disorders
#12
Megan Eversole, Diane M Collins, Amol Karmarkar, Lisa Colton, Jill Phillips Quinn, Rita Karsbaek, Jessica Reinken Johnson, Nicolle Patricia Callier, Claudia L Hilton
Enjoyment is a fundamental component of activity participation. This study compared leisure activity enjoyment experienced by typically developing children (TD; n = 64) and those with autism spectrum disorders (ASD; n = 67) from age 6 to 13. The TD children enjoyed formal and physical activities significantly more than the children with ASD. Symptom severity was negatively related to enjoyment of overall, formal, physical and social activities. Older children with ASD enjoyed overall, informal, recreational, and self-improvement activities significantly less than younger children, but no differences were seen across TD age groups...
January 2016: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/25882707/two-knockdown-models-of-the-autism-genes-syngap1-and-shank3-in-zebrafish-produce-similar-behavioral-phenotypes-associated-with-embryonic-disruptions-of-brain-morphogenesis
#13
Robert A Kozol, Holly N Cukier, Bing Zou, Vera Mayo, Silvia De Rubeis, Guiqing Cai, Anthony J Griswold, Patrice L Whitehead, Jonathan L Haines, John R Gilbert, Michael L Cuccaro, Eden R Martin, James D Baker, Joseph D Buxbaum, Margaret A Pericak-Vance, Julia E Dallman
Despite significant progress in the genetics of autism spectrum disorder (ASD), how genetic mutations translate to the behavioral changes characteristic of ASD remains largely unknown. ASD affects 1-2% of children and adults, and is characterized by deficits in verbal and non-verbal communication, and social interactions, as well as the presence of repetitive behaviors and/or stereotyped interests. ASD is clinically and etiologically heterogeneous, with a strong genetic component. Here, we present functional data from syngap1 and shank3 zebrafish loss-of-function models of ASD...
July 15, 2015: Human Molecular Genetics
https://www.readbyqxmd.com/read/25549857/effects-of-npas4-deficiency-on-anxiety-depression-like-cognition-and-sociability-behaviour
#14
Emily J Jaehne, Thomas S Klarić, Simon A Koblar, Bernhard T Baune, Martin D Lewis
The transcription factor neuronal PAS domain-containing protein 4 (Npas4), which regulates the formation of inhibitory synapses on excitatory neurons, has been suggested as a candidate gene for neurological and psychiatric conditions such as bipolar depression, autism spectrum and cognitive disorders. A mouse model of Npas4 deficiency has been developed to investigate any role in these disorders. Behavioural characterisation of Npas4(-/-), Npas4(+/-) and Npas4(+/+) mice has been conducted using the open field, elevated zero maze (EZM), Y-maze, sociability test and forced swim test (FST) to investigate a range of behaviours...
March 15, 2015: Behavioural Brain Research
https://www.readbyqxmd.com/read/25069191/-influence-of-acupuncture-of-changqiang-gv-1-on-learning-memory-ability-and-gap-junction-related-protein-expression-in-the-prefrontal-cortex-in-autism-rats
#15
Yu-Zhu Hong, Xue-Jun Zhang, Lin Hong, Qian-Ru Huang, Qiang Wu
OBJECTIVE: To observe the effect of acupuncture stimulation of "Changqiang" (GV 1) on learning-memory ability and gap junction-related protein expression in the prefrontal cortex in autism rats. METHODS: Forty Wistar rats were equally randomized into control, model, GV 1 and non-acupoint groups. For establishing autism model, Valproate acid (VPA) sodium (600 mg/kg) was given (i. p.) to pregnancy rats whose intimate filial generation was confirmed to be successful autism by eye-open tests, swimming test and Morris water maze swimming tasks...
June 2014: Zhen Ci Yan Jiu, Acupuncture Research
https://www.readbyqxmd.com/read/24768643/mice-over-expressing-bdnf-in-forebrain-neurons-develop-an-altered-behavioral-phenotype-with-age
#16
Kate L Weidner, Diego F Buenaventura, Kathryn K Chadman
Evidence from clinical studies suggests that abnormal activity of brain derived neurotrophic factor (BDNF) contributes to the pathogenesis of autism spectrum disorders (ASDs). A genetically modified line of mice over-expressing a BDNF transgene in forebrain neurons was used to investigate if this mutation leads to changes in behavior consistent with ASD. The mice used in these experiments were behaviorally tested past 5 months of age when spontaneous seizures were evident. These seizures were not observed in age-matched wildtype (WT) mice or younger mice from this transgenic line...
July 15, 2014: Behavioural Brain Research
https://www.readbyqxmd.com/read/24730055/chronic-desipramine-treatment-rescues-depression-related-social-and-cognitive-deficits-in-engrailed-2-knockout-mice
#17
J Brielmaier, J M Senerth, J L Silverman, P G Matteson, J H Millonig, E DiCicco-Bloom, J N Crawley
Engrailed-2 (En2) is a homeobox transcription factor that regulates neurodevelopmental processes including neuronal connectivity and elaboration of monoaminergic neurons in the ventral hindbrain. We previously reported abnormalities in brain noradrenergic concentrations in En2 null mutant mice that were accompanied by increased immobility in the forced swim test, relevant to depression. An EN2 genetic polymorphism has been associated with autism spectrum disorders, and mice with a deletion in En2 display social abnormalities and cognitive deficits that may be relevant to multiple neuropsychiatric conditions...
March 2014: Genes, Brain, and Behavior
https://www.readbyqxmd.com/read/24631552/ncs-1-deficiency-causes-anxiety-and-depressive-like-behavior-with-impaired-non-aversive-memory-in-mice
#18
Vitor Bortolo de Rezende, Daniela Valadão Rosa, Clarissa Martinelli Comim, Luiz Alexandre Viana Magno, Ana Lucia Severo Rodrigues, Paula Vidigal, Andreas Jeromin, João Quevedo, Marco Aurélio Romano-Silva
Sensing and regulating intracellular levels of calcium are essential for proper cellular function. In neurons, calcium sensing plays important roles in neuronal plasticity, neurotransmitter release, long-term synapse modification and ion channel activity. Neuronal calcium sensor-1 (NCS-1) is a member of the highly conserved neuronal calcium sensor family. Although NCS-1 has been associated with psychiatric conditions including autism, bipolar disorder and schizophrenia, it is unclear which role NCS-1 plays in behavior...
May 10, 2014: Physiology & Behavior
https://www.readbyqxmd.com/read/24617090/-aquatic-therapy-for-children-with-autism
#19
Estelle Amoros, Alexandra Tzvetkovitch
Nursing practices with autistic children in child psychiatry can be approached through the experience of a body-centred therapy group. The support favours creativity, holding, vocal interaction, team work around the clinical aspect, multi-disciplinary perspectives and exchanges with the parents. An example of a workshop in a swimming pool in which holding is particularly important.
January 2014: Soins. Pédiatrie, Puériculture
https://www.readbyqxmd.com/read/24326014/strain-dependent-effects-of-prenatal-maternal-immune-activation-on-anxiety-and-depression-like-behaviors-in-offspring
#20
Shirin Babri, Mohammad-Hossein Doosti, Ali-Akbar Salari
There is converging evidence that prenatal maternal infection can increase the risk of occurrence of neuropsychiatric disorders like schizophrenia, autism, anxiety and depression in later life. Experimental studies have shown conflicting effects of prenatal maternal immune activation on anxiety-like behavior and hypothalamic-pituitary-adrenal (HPA) axis development in offspring. We investigated the effects of maternal immune activation during pregnancy on anxiety- and depression-like behaviors in pregnant mice and their offspring to determine whether these effects are dependent on strain...
March 2014: Brain, Behavior, and Immunity
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