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Na k atpase

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https://www.readbyqxmd.com/read/28100217/variation-in-branchial-expression-among-insulin-like-growth-factor-binding-proteins-igfbps-during-atlantic-salmon-smoltification-and-seawater-exposure
#1
Jason P Breves, Chelsea K Fujimoto, Silas K Phipps-Costin, Ingibjörg E Einarsdottir, Björn Thrandur Björnsson, Stephen D McCormick
BACKGROUND: In preparation for migration from freshwater to marine habitats, Atlantic salmon (Salmo salar L.) undergo smoltification, a transformation that includes the acquisition of hyposmoregulatory capacity. The growth hormone (Gh)/insulin-like growth-factor (Igf) axis promotes the development of branchial ionoregulatory functions that underlie ion secretion. Igfs interact with a suite of Igf binding proteins (Igfbps) that modulate hormone activity. In Atlantic salmon smolts, igfbp4,-5a,-5b1,-5b2,-6b1 and-6b2 transcripts are highly expressed in gill...
January 18, 2017: BMC Physiology
https://www.readbyqxmd.com/read/28100180/extensive-bilateral-corneal-edema-6%C3%A2-weeks-after-cataract-surgery-keratopathy-due-to-asclepias-physocarpa-a-case-report
#2
Kazuki Matsuura, Shiro Hatta, Yuki Terasaka, Yoshitsugu Inoue
BACKGROUND: Surgeons may be unaware of the ability of plant toxins to cause corneal damage. Therefore, corneal damage following intraocular surgery due to plant toxins may be misdiagnosed as postoperative infection. CASE PRESENTATION: A 74-year-old man presented with hyperemia and reduced visual acuity in both eyes 6 weeks after uneventful cataract surgery. We observed extensive hyperemia and corneal stromal edema with Descemet's folds in both eyes. After obtaining a detailed patient history, we diagnosed plant toxin-induced corneal edema due to Asclepias physocarpa, which can induce corneal edema by inhibiting the Na(+)/K(+) ATPase activity of the corneal endothelium...
January 18, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28089998/first-clinical-experience-with-targeted-renal-nerve-demodulation-trend-1-using-a-neurotropic-agent-for-the-treatment-of-sympathetic-hypertension
#3
Nicholas Kipshidze, Horst Sievert, Michael H Wholey, Konstantin Kipiani, Vakhtang Kipiani, Tea Mukhuradze, Mark Wholey, Emily Stein, K T Venkateswara Rao
AIMS: To evaluate the feasibility and safety of a novel targeted neuromodulatory treatment for sympathetic hypertension involving a one-time local injection of neurotropic agents near renal nerves. METHODS AND RESULTS: Seven patients suffering from uncontrolled hypertension per ESH-ESC guidelines were treated using a single dose of NW2013, a neurotropic Na+/K+ ATPase antagonist. A microneedle catheter was used to administer 1.2 mL of NW2013 (0.6 mL per artery) to the perivascular space surrounding renal arteries using percutaneous endovascular procedures under fluoroscopic guidance...
January 15, 2017: Journal of Invasive Cardiology
https://www.readbyqxmd.com/read/28089857/na-k-atpase-activity-in-the-anoxic-turtle-trachemys-scripta-brain-at-different-acclimation-temperature
#4
Jonathan A W Stecyk, Anthony P Farrell, Matti Vornanen
Survival of prolonged anoxia requires a balance between cellular ATP demand and anaerobic ATP supply from glycolysis, especially in critical tissues such as the brain. To add insight into the ATP demand of the brain of the anoxia-tolerant red-eared slider turtle (Trachemys scripta) during prolonged periods of anoxic submergence, we quantified and compared the number of Na(+)-K(+)-ATPase units and their molecular activity in brain tissue from turtles acclimated to either 21°C or 5°C and exposed to either normoxia or anoxia (6h 21°C; 14 d at 5°C)...
January 12, 2017: Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology
https://www.readbyqxmd.com/read/28079752/changes-in-dorsal-root-ganglion-gene-expression-in-response-to-spinal-cord-stimulation
#5
Dana M Tilley, David L Cedeño, Courtney A Kelley, Margaret DeMaegd, Ramsin Benyamin, Ricardo Vallejo
BACKGROUND AND OBJECTIVES: Spinal cord stimulation (SCS) has been shown to influence pain-related genes in the spinal cord directly under the stimulating electrodes. There is limited information regarding changes occurring at the dorsal root ganglion (DRG). This study evaluates gene expression in the DRG in response to SCS therapy. METHODS: Rats were randomized into experimental or control groups (n = 6 per group). Experimental animals underwent spared-nerve injury, implantation of lead, and continuous SCS (72 hours)...
January 11, 2017: Regional Anesthesia and Pain Medicine
https://www.readbyqxmd.com/read/28069354/bufadienolides-from-amphibians-a-promising-source-of-anticancer-prototypes-for-radical-innovation-apoptosis-triggering-and-na-k-atpase-inhibition
#6
REVIEW
Lívia Queiroz de Sousa, Kátia da Conceição Machado, Samara Ferreira de Carvalho Oliveira, Lidiane da Silva Araújo, Evaldo Dos Santos Monção-Filho, Ana Amélia de Carvalho Melo-Cavalcante, Gerardo Magela Vieira-Júnior, Paulo Michel Pinheiro Ferreira
Amphibians present pharmacologically active aliphatic, aromatic and heterocyclic molecules in their skin as defense against microorganisms, predators and infections, such as steroids, alkaloids, biogenic amines, guanidine derivatives, proteins and peptides. Based on the discovered bioactive potential of bufadienolides, this work reviewed the contribution of amphibians, especially from members of Bufonidae family, as source of new cytotoxic and antitumor molecules, highlighting the mechanisms responsible for such amazing biological potentialities...
January 7, 2017: Toxicon: Official Journal of the International Society on Toxinology
https://www.readbyqxmd.com/read/28066011/role-of-membrane-cholesterol-and-lipid-peroxidation-in-regulating-the-na-k-atpase-activity-in-schizophrenia
#7
Suparna Roy, Anindya Dasgupta, Ushasi Banerjee, Piali Chowdhury, Ashis Mukhopadhyay, Gautam Saha, Omprakash Singh
BACKGROUND: Na(+)/K(+)-ATPase (NKA) activity is compromised in several neuropsychiatric disorders. Oxidative stress and membrane lipid composition play important roles in regulating NKA activity. AIMS: The present study was undertaken to evaluate the effects of oxidative stress-induced membrane lipid damage and membrane cholesterol composition on NKA pump activity in schizophrenia. SETTINGS AND DESIGN: It was a hospital-based, cross-sectional, observational study in 49 cases and 51 controls for 1 year...
July 2016: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/28065737/osmoregulatory-role-of-vasotocinergic-and-isotocinergic-systems-in-the-gilthead-sea-bream-sparus-aurata-l
#8
Juan Miguel Mancera, Gonzalo Martínez-Rodríguez, Arleta Krystyna Skrzynska, Juan Antonio Martos-Sitcha
Gilthead sea bream, Sparus aurata L., is an important fish species for the Mediterranean aquaculture and is considered a good model for studying the osmoregulatory process, due to its capacity to cope with great changes in environmental salinity (5-60 ‰). Our group studied the osmoregulatory role of different endocrine systems in this species, focusing on the vasotocinergic and isotocinergic systems over several years. For this purpose, the cDNAs coding for pro-vasotocin (pro-vt), pro-isotocin (pro-it), two arginine vasotocin (AVT) receptors (avtr v1a2- and v2-types) and one IT receptor (itr) were cloned...
January 5, 2017: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/28065674/mitochondria-in-teleost-spermatozoa
#9
REVIEW
Patricio Ulloa-Rodríguez, Elías Figueroa, Rommy Díaz, Manuel Lee-Estevez, Stefania Short, Jorge G Farías
There is an extraordinary diversity of reproductive modes in teleost and this variability is related to the phylogenetic relationships and adaption to very different biotopes. As in all vertebrates, sperm is produced as the end product of the process of spermatogenesis, and regarding teleost the spermatozoa lack an acrosome in almost all species and motility is activated as a response to osmolarity and ion content of the aquatic medium where the sperm is released. In this context, mitochondria possess a fundamental role for fish spermatozoa motility and integrity, hence, fertilizing potential; they are the energy supplier that allows flagellar movement and their dysfunction could play a main role in structural and functional damage to the spermatozoa...
January 5, 2017: Mitochondrion
https://www.readbyqxmd.com/read/28064049/anti-diarrhoeal-therapeutic-potential-and-safety-assessment-of-sulphated-polysaccharide-fraction-from-gracilaria-intermedia-seaweed-in-mice
#10
Ana Carolina M Leódido, Luis E C Costa, Thiago S L Araújo, Douglas S Costa, Nayara A Sousa, Luan K M Souza, Francisca B M Sousa, Manoel D S Filho, Daniel F P Vasconcelos, Felipe R P Silva, Kerolayne M Nogueira, Alyne R Araújo, Francisco Clark N Barros, Ana Lúcia P Freitas, Jand Venes R Medeiros
Sulphated polysaccharides extracted from algae have been extensively studied for their diverse biological activities. Thus, the purpose of this study was to evaluate the chemical composition, the anti-diarrhoeal effect and acute toxicity of a sulphated polysaccharide fraction obtained from Gracilaria intermedia (SP-Gi). Initially, the FT-IR of SP-Gi revealed to be an agaran with sulphation at C-6 of the l-galactosyl residues. The anti-diarrhoeal activity of SP-Gi was evaluated in a castor oil-induced diarrhoea model...
January 5, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28063409/tinospora-cordifolia-extract-attenuates-cadmium-induced-biochemical-and-histological-alterations-in-the-heart-of-male-wistar-rats
#11
Lohanathan Bharathi Priya, Rathinasamy Baskaran, Pitchai Elangovan, Velumani Dhivya, Chih-Yang Huang, Viswanadha Vijaya Padma
Persistence of cadmium (Cd) in the environment causes serious ecological problems. Tinospora cordifolia is a medicinal herb used in Ayurveda for treating various metabolic disorders and toxic conditions. The present study investigates the protective effect of T. cordifolia stem methanolic extract (TCME) on a heavy metal, Cd-induced cardiotoxicity in male Wistar rats. Male albino Wistar rats were divided into four groups (n=6). The animals after treatment for 28days with Cd and TCME were analysed for biochemical and histological changes in the serum and heart tissues...
January 4, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28062481/sex-specific-effects-of-sex-steroids-on-alveolar-epithelial-na-transport
#12
Melanie Haase, Mandy Laube, Ulrich H Thome
Alveolar fluid clearance mediates perinatal lung transition to air breathing in newborn infants, which is accomplished by epithelial Na+ channels (ENaC) and the Na,K-ATPase. Male sex represents a major risk factor for developing respiratory distress, especially in preterm infants. We previously showed that male sex is associated with reduced epithelial Na+ transport, possibly contributing to the sexual dimorphism in newborn respiratory distress. This study aimed to determine sex-specific effects of sex steroids on epithelial Na+ transport...
January 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28043416/antidiarrhoeal-investigation-of-apium-leptophyllum-pers-by-modulation-of-na-k-atpase-nitrous-oxide-and-intestinal-transit-in-rats
#13
Himanshu Bhusan Sahoo, Rakesh Sagar, Anjan Kumar, Amrita Bhaiji, Subrat Kumar Bhattamishra
BACKGROUND: Apium leptophyllum (Pers.) is an annual herb with traditional appreciation for various pharmacological properties; however, the scientific information on this herb is insufficient. The aim of the present investigation was undertaken to evaluate flavonoidal fraction of A. leptophyllum fruit (FFALF) against diarrhoea on albino rats. METHODS: The antidiarrhoeal study was conducted by castor oil induce diarrhoea, prostaglandin E2 (PGE2) induced enteropooling and intestinal transit by charcoal meal test...
December 2016: Biomedical Journal
https://www.readbyqxmd.com/read/28039090/effects-of-previous-physical-exercise-to-chronic-stress-on-long-term-aversive-memory-and-oxidative-stress-in-amygdala-and-hippocampus-of-rats
#14
Tiago Marcon Dos Santos, Janaína Kolling, Cassiana Siebert, Helena Biasibetti, Carolina Gessinger Bertó, Lucas Kich Grun, Carla Dalmaz, Florencia María Barbé-Tuana, Angela T S Wyse
Since stressful situations are considered risk factors for the development of depression and there are few studies evaluating prevention therapies for this disease, in the present study we evaluated the effect of previous physical exercise in animals subjected to chronic variable stress (CVS), an animal model of depression, on behavior tasks. We also investigated some parameters of oxidative stress and Na(+), K(+)-ATPase activity, immunocontent and gene expression of alpha subunits in amygdala and hippocampus of rats...
December 27, 2016: International Journal of Developmental Neuroscience
https://www.readbyqxmd.com/read/28028214/arginine-substitution-of-a-cysteine-in-transmembrane-helix-m8-converts-na-k-atpase-to-an-electroneutral-pump-similar-to-h-k-atpase
#15
Rikke Holm, Jaanki Khandelwal, Anja P Einholm, Jens P Andersen, Pablo Artigas, Bente Vilsen
Na(+),K(+)-ATPase and H(+),K(+)-ATPase are electrogenic and nonelectrogenic ion pumps, respectively. The underlying structural basis for this difference has not been established, and it has not been revealed how the H(+),K(+)-ATPase avoids binding of Na(+) at the site corresponding to the Na(+)-specific site of the Na(+),K(+)-ATPase (site III). In this study, we addressed these questions by using site-directed mutagenesis in combination with enzymatic, transport, and electrophysiological functional measurements...
January 10, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28027877/hydrogen-sulfide-may-attenuate-methylmercury-induced-neurotoxicity-via-mitochondrial-preservation
#16
Junyan Han, Xuelian Yang, Xuehua Chen, Zhiqiang Li, Ming Fang, Bing Bai, Dehong Tan
Hydrogen sulfide (H2S) is a protective molecule and a novel gaseous mediator. Here we explored whether H2S donor (NaHS) could attenuate methylmercury (MeHg)-induced neurotoxicity in rats. The adult rats were randomly divided into four groups, i.e., control, NaHS, MeHg, and NaHS + MeHg groups. Rats of the NaHS + MeHg group were intraperitoneally (i.p) injected with 5.6 mg/kg/d of NaHS together with 5 μg/kg/d of MeHg. Rats of the MeHg group and NaHS group were injected with 5 μg/kg/d of MeHg and 5.6 mg/kg/d of NaHS, respectively...
December 24, 2016: Chemico-biological Interactions
https://www.readbyqxmd.com/read/28027400/elevated-intracellular-na-concentrations-in-developing-spinal-neurons
#17
Casie Lindsly, Carlos Gonzalez-Islas, Peter Wenner
Over 25 years ago it was first reported that intracellular chloride levels (Cl(-)in ) were higher in developing neurons than in maturity. This finding has had significant implications for understanding the excitability of developing networks and recognizing the underlying causes of hyperexcitability associated with disease and neural injury. While there is some evidence that intracellular sodium levels (Na(+)in ) change during the development of non-neural cells, it has largely been assumed that Na(+)in is the same in developing and mature neurons...
December 27, 2016: Journal of Neurochemistry
https://www.readbyqxmd.com/read/28018232/membrane-lipid-microenvironment-modulates-thermodynamic-properties-of-the-na-k-atpase-in-branchial-and-intestinal-epithelia-in-euryhaline-fish-in-vivo
#18
Mario Díaz, Rosa Dópido, Tomás Gómez, Covadonga Rodríguez
We have analyzed the effects of different native membrane lipid composition on the thermodynamic properties of the Na(+)-K(+)-ATPase in different epithelia from the gilthead seabream Sparus aurata. Thermodynamic parameters of activation for the Na(+)-K(+)-ATPase, as well as contents of lipid classes and fatty acids from polar lipids were determined for gill epithelia and enterocytes isolated from pyloric caeca, anterior intestine and posterior intestine. Arrhenius analyses of control animals revealed differences in thermal discontinuity values (Td) and activation energies determined at both sides of Td between intestinal and gill epithelia...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/28018231/slowly-adapting-sensory-units-have-more-receptors-in-large-airways-than-in-small-airways-in-rabbits
#19
Jun Liu, Nana Song, Juan Guardiola, Jesse Roman, Jerry Yu
Sensory units of pulmonary slowly adapting receptors (SARs) are more active in large airways than in small airways. However, there is no explanation for this phenomenon. Although sensory structures in large airways resemble those in small airways, they are bigger and more complex. Possibly, a larger receptor provides greater surface area for depolarization, and thus has a lower activating threshold and/or a higher sensitivity to stretch, leading to more nerve electrical activities. Recently, a single sensory unit has been reported to contain multiple receptors...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/28012845/role-of-melatonin-in-mitigating-nonylphenol-induced-toxicity-in-frontal-cortex-and-hippocampus-of-rat-brain
#20
Heena Tabassum, Mohammad Ashafaq, Suhel Parvez, Sheikh Raisuddin
Nonylphenol (NP), an environmental endocrine disruptor mimics estrogen and is a potential toxicant both under in vitro and in vivo conditions. In this study, the effect of melatonin on NP- induced neurotoxicity and cognitive alteration was investigated in adult male Wistar rats. Melatonin supplementation has been known to protect cells from neurotoxic injury. The animals were divided into three groups namely, control (vehicle) which received olive oil orally and treated rats received NP (25 mg/kg, per os) thrice a week for 45 days while the third group i...
December 21, 2016: Neurochemistry International
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