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https://www.readbyqxmd.com/read/28206954/rassf1a-promoter-methylation-in-high-grade-serous-ovarian-cancer-a-direct-comparison-study-in-primary-tumors-adjacent-morphologically-tumor-cell-free-tissues-and-paired-circulating-tumor-dna
#1
Lydia Giannopoulou, Issam Chebouti, Kitty Pavlakis, Sabine Kasimir-Bauer, Evi S Lianidou
The RASSF1A promoter is frequently methylated in high-grade serous ovarian cancer (HGSC). We examined RASSF1A promoter methylation in primary tumors, adjacent morphologically tumor cell-free tissues and corresponding circulating tumor DNA (ctDNA) samples of patients with HGSC, using a real-time methylation specific PCR (real-time MSP) and a methylation-sensitive high-resolution melting analysis (MS-HRMA) assay for the detection and semi-quantitative estimation of methylation, respectively. Two groups of primary HGSC tumor FFPE samples were recruited (Group A n=67 and Group B n=61), along with matched adjacent morphologically tumor cell-free tissues (n=58) and corresponding plasma samples (n=59) for group B...
February 10, 2017: Oncotarget
https://www.readbyqxmd.com/read/28202692/localization-of-phosphorylated-connexin-43-by-serial-section-immunogold-electron-microscopy
#2
Rachael P Norris, Valentina Baena, Mark Terasaki
Gap junction turnover occurs by the internalization of both plasma membranes of a gap junction plaque to form a double membrane-enclosed vesicle, or connexosome. Phosphorylation has a key role in regulation, but further progress requires clearly distinguishing gap junctions and connexosomes and precisely localizing proteins to them. We examined by electron microscopy serial sections of mouse preovulatory ovarian follicles collected with an automated tape collecting ultramicrotome (ATUM). We found connexosomes may form from adjacent cell bodies, from thin cell processes, or from the same cell...
February 15, 2017: Journal of Cell Science
https://www.readbyqxmd.com/read/28199067/human-epididymis-protein-4-immunostaining-of-malignant-ascites-differentiates-cancer-of-m%C3%A3-llerian-origin-from-gastrointestinal-cancer
#3
Anna Stiekema, Koen K Van de Vijver, Henk Boot, Annegien Broeks, Catharina M Korse, Willemien J van Driel, Gemma G Kenter, Christianne A R Lok
BACKGROUND: An accurate diagnosis of cancer of Müllerian origin is required before the initiation of treatment. An overlap in clinical presentation and cytological, histological, or imaging studies with other nongynecological tumors does occur. Therefore, immunocytochemistry markers are used to determine tumor origin. Human epididymis protein 4 (HE4) is overexpressed in tissue of epithelial ovarian cancer (EOC). It has shown to be a sensitive and specific serum marker for EOC and to be of value for the differentiation between EOC and ovarian metastases of gastrointestinal origin...
February 15, 2017: Cancer
https://www.readbyqxmd.com/read/28194593/synchronous-endometrial-and-ovarian-carcinomas-predictors-of-risk-and-associations-with-survival-and-tumor-expression-profiles
#4
Linda E Kelemen, Peter F Rambau, Jennifer M Koziak, Helen Steed, Martin Köbel
PURPOSE: Synchronous endometrial and ovarian tumors (SEOs) are diagnosed in 10% of ovarian cancer patients. We examined predictors of SEOs, evaluated associations of SEOs with survival and characterized ovarian tumor profiles using immunohistochemistry. METHODS: We included patients with endometrioid (n = 180) and clear cell (n = 165) ovarian carcinoma identified from the Alberta Cancer Registry between 1979 and 2010 for whom we abstracted medical records and constructed tumor tissue microarrays (TMAs)...
February 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28187748/characterization-of-ovarian-clear-cell-carcinoma-using-target-drug-based-molecular-biomarkers-implications-for-personalized-cancer-therapy
#5
Mengjiao Li, Haoran Li, Fei Liu, Rui Bi, Xiaoyu Tu, Lihua Chen, Shuang Ye, Xi Cheng
BACKGROUND: It has long been appreciated that different subtypes (serous, clear cell, endometrioid and mucinous) of epithelial ovarian carcinoma (EOC) have distinct pathogenetic pathways. However, clinical management, especially chemotherapeutic regimens, for EOC patients is not subtype specific. Ovarian clear cell carcinoma (CCC) is a rare histological subtype of EOC, which exhibits high rates of recurrence and low chemosensitivity. We assessed potential therapeutic targets for ovarian CCC patients through analyzing the variation of drug-based molecular biomarkers expression between ovarian CCC and high-grade serous carcinoma (HGSC)...
February 10, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28184014/autophagy-inhibition-enhances-sunitinib-efficacy-in-clear-cell-ovarian-carcinoma
#6
Lindsay DeVorkin, Matthew Hattersley, Paul Kim, Jenna Ries, Jaeline Spowart, Michael S Anglesio, Samuel M Levi, David G Huntsman, Ravi K Amaravadi, Jeffrey D Winkler, Anna V Tinker, Julian J Lum
Clear cell ovarian carcinoma (CCOC) is an aggressive form of epithelial ovarian cancer that exhibits low response rates to systemic therapy and poor patient outcomes. Multiple studies in CCOC have revealed expression profiles consistent with increased hypoxia, and our previous data suggest that hypoxia is correlated with increased autophagy in CCOC. Hypoxia-induced autophagy is a key factor promoting tumor cell survival and resistance to therapy. Recent clinical trials with the molecular-targeted receptor tyrosine kinase (RTK) inhibitor sunitinib have demonstrated limited activity...
February 9, 2017: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/28181328/protein-and-mrna-expression-of-follicle-stimulating-hormone-receptor-and-luteinizing-hormone-receptor-during-the-oestrus-in-the-yak-bos-grunniens
#7
S-D Huo, S-E Chen, R-J Long, J-T Yang, J-X Lu, R-X Zang, T-J Zhang, A Abudureyimu, J-L Liu, G-H Zhang, Y-Q Zhao, Z-R Ma
Follicle-stimulating hormone (FSH) and luteinizing hormone (LH) have a central role in follicle growth, maturation and oestrus, but no clear pathway in the seasonal oestrus of yak (Bos grunniens) has been found. To better understand the role of FSH and LH in seasonal oestrus in the yak, six yaks were slaughtered while in oestrus, and the pineal gland, hypothalamus, pituitary gland, and gonads were collected. Using real-time PCR and immunohistochemical assays, we determined the mRNA and protein expression of the FSH and LH receptors (FSHR and LHR) in these organs...
February 8, 2017: Reproduction in Domestic Animals, Zuchthygiene
https://www.readbyqxmd.com/read/28179304/imp3-expression-in-borderline-tumors-of-the-ovary
#8
Ahmed El-Balat, Nicole Sänger, Thomas Karn, Sven Becker, Uwe Holtrich, Zelal Muallem, Ruza Arsenic
BACKGROUND/AIM: Borderline ovarian tumors (BOTs) have a less aggressive behavior than invasive epithelial ovarian tumors. Still some patients relapse or succumb to disease. Molecular markers that reliably predict prognosis are lacking. Insulin-like growth factor II mRNA-binding protein (IMP3) has been suggested as a prognostic marker in colorectal, hepatocellular, and ovarian clear-cell carcinomas. MATERIALS AND METHODS: We analyzed the expression of IMP3 by immunohistochemistry in a cohort of 140 BOT and its association with histopathological features...
2017: Anticancer Research
https://www.readbyqxmd.com/read/28173214/ugt1a1-polymorphism-as-a-prognostic-indicator-of-stage-i-ovarian-clear-cell-carcinoma-patients-treated-with-irinotecan
#9
Tomoko Yoshihama, Akira Hirasawa, Hiroyuki Nomura, Tomoko Akahane, Yoshiko Nanki, Wataru Yamagami, Fumio Kataoka, Eiichiro Tominaga, Nobuyuki Susumu, Taisei Mushiroda, Daisuke Aoki
No abstract text is available yet for this article.
February 4, 2017: Japanese Journal of Clinical Oncology
https://www.readbyqxmd.com/read/28161486/microrna-424-inhibits-cell-migration-invasion-and-epithelial-mesenchymal-transition-by-downregulating-doublecortin-like-kinase-1-in-ovarian-clear-cell-carcinoma
#10
Xin Wu, Yuanyuan Ruan, Hua Jiang, Congjian Xu
Doublecortin-like kinase 1 (DCLK1) is overexpressed in many cancers and acts as a tumor stem cell marker. Here, we investigated the role of DCLK1 and microRNA-424 (miR-424) in ovarian clear cell carcinoma (OCCC), a histopathologically distinct subtype of epithelial ovarian cancer associated with poor prognosis and chemotherapy resistance. Analysis of samples from 30 OCCC patients showed that DCLK1 was upregulated and miR-424 was downregulated in tumors compared with adjacent non-tumor tissues. DCLK1 overexpression promoted OCCC cell proliferation, migration, and invasion, whereas DCLK1 knockdown reduced cell viability and invasion and induced growth arrest in vitro and in vivo...
February 2, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28133347/-ovarian-cancer-rupture-causing-acute-abdomen-that-required-emergency-surgery-a-case-report
#11
Yoshihito Yamakoshi, Naoki Aomatsu, Noriyuki Yamasaki, Chihoko Nobori, Shigeaki Kurihara, En Wang, Daisuke Nagashima, Toshiki Hirakawa, Takehiko Iwauchi, Junya Morimoto, Seika Tei, Kazunori Nakazawa, Yasutake Uchima, Kazuhiro Takeuchi
A 50-year-old post-menopausal woman with sudden lower abdominal pain was transported to hospital by ambulance. Abdominal symptoms and computed tomography(CT)suggested a diagnosis of acute pan-peritonitis due to gastrointestinal perforation, and emergency surgery was performed. The intraoperative findings led to a diagnosis of a ruptured cyst in the left ovary, a portion of which was observed to be partially solid, and therefore, ovarian cancer was suspected. Accordingly, a unilateral(left)salpingo-oophorectomy and intraperitoneal drainage were performed with assistance from a gynecologist...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133240/-a-case-of-primary-peritoneal-cancer-successfully-treated-with-debulking-surgery-and-postoperative-chemotherapy
#12
Koki Maeda, Masami Tabata, Taiki Moriyama, Tatsuya Sakamoto, Yu Fujimura, Ichiro Ohsawa, Kenji Kato, Makoto Iwata, Takayuki Sanda
A 52-year-old woman with abdominal pain and a feeling of incomplete evacuation visited a local clinic. Enlargement of the right ovary was detected, and the patient was referred to the gynecological department of our hospital. CT and MRI revealed a round-shaped mass, 8 cm in diameter, with cystic and solid components in the Douglas pouch. The patient underwent a laparotomy under the diagnosis of ovarian cancer. Intraoperatively, both the ovaries appeared normal and the tumor strongly adhered to the rectum and uterus...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28123539/bilateral-ovarian-carcinomas-differ-in-the-expression-of-metastasis-related-genes
#13
Marianne Lislerud Smebye, Lisbeth Haugom, Ben Davidson, Claes Göran Trope, Sverre Heim, Rolf Inge Skotheim, Francesca Micci
The mechanisms behind bilaterality of ovarian carcinomas are not fully understood, as the two tumors could possibly represent two primary tumors, a primary tumor and a metastasis, or two metastases. The gene expression profiles from bilateral high-grade serous carcinomas (HGSCs) and clear cell carcinomas (CCCs) of the ovary were compared to study the association between the tumors of the two sides. A separate analysis of genes from chromosome 19 was also performed, since this chromosome is frequently rearranged in ovarian carcinomas...
January 2017: Oncology Letters
https://www.readbyqxmd.com/read/28115406/genetic-variants-in-epigenetic-pathways-and-risks-of-multiple-cancers-in-the-game-on-consortium
#14
Reka Toth, Dominique Scherer, Linda E Kelemen, Angela Risch, Aditi Hazra, Yesilda Balavarca, Jean-Pierre J Issa, Victor Moreno, Rosalind A Eeles, Shuji Ogino, Xifeng Wu, Yuanqing Ye, Rayjean J Hung, Ellen L Goode, Cornelia M Ulrich
BACKGROUND: Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background. METHODS: In a subsets (ASSET) meta-analytic approach, we investigated associations of genetic variants related to epigenetic mechanisms with risks of breast, lung, colorectal, ovarian and prostate carcinomas using 51,724 cases and 52,001 controls. False-discovery-rate corrected p-values (q-values < 0.05) were considered statistically significant...
January 23, 2017: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/28112439/abcf2-an-nrf2-target-gene-contributes-to-cisplatin-resistance-in-ovarian-cancer-cells
#15
Lingjie Bao, Jianfa Wu, Matthew Dodson, Elisa Montserrat Rojo de la Vega, Yan Ning, Zhenbo Zhang, Ming Yao, Donna D Zhang, Congjian Xu, Xiaofang Yi
Previously, we have demonstrated that NRF2 plays a key role in mediating cisplatin resistance in ovarian cancer. To further explore the mechanism underlying NRF2-dependent cisplatin resistance, we stably overexpressed or knocked down NRF2 in parental and cisplatin-resistant human ovarian cancer cells, respectively. These two pairs of stable cell lines were then subjected to microarray analysis, where we identified 18 putative NRF2 target genes. Among these genes, ABCF2, a cytosolic member of the ABC superfamily of transporters, has previously been reported to contribute to chemoresistance in clear cell ovarian cancer...
January 23, 2017: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/28112360/low-uptake-of-fluorodeoxyglucose-in-positron-emission-tomography-computed-tomography-in-ovarian-clear-cell-carcinoma-may-reflect-glutaminolysis-of-its-cancer-stem-cell-like-properties
#16
Masakazu Sato, Kei Kawana, Katsuyuki Adachi, Asaha Fujimoto, Ayumi Taguchi, Tomona Fujikawa, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Juri Ogishima, Satoko Eguchi, Aki Yamashita, Kensuke Tomio, Takahide Arimoto, Osamu Wada-Hiraike, Katsutoshi Oda, Takeshi Nagamatsu, Yutaka Osuga, Tomoyuki Fujii
The characteristics of ovarian cancers that showed low activation of glycolysis were investigated. Using medical records of patients with ovarian cancers who had undergone fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT) prior to their primary surgery at the University of Tokyo Hospital between 2010 and 2015, we identified cases with a low uptake of FDG in PET/CT. We considered the maximum standardized uptake value (SUVmax) as the degree of glucose uptake. We investigated the properties which may account for the low activation of glycolysis in vitro...
January 20, 2017: Oncology Reports
https://www.readbyqxmd.com/read/28111949/biocompatible-lipid-nanoparticles-as-carriers-to-improve-curcumin-efficacy-in-ovarian-cancer-treatment
#17
Maria Luisa Bondì, Maria Rita Emma, Chiara Botto, Giuseppa Augello, Antonina Azzolina, Francesca Di Gaudio, Emanuela Fabiola Craparo, Gennara Cavallaro, Dimcho Bachvarov, Melchiorre Cervello
Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumoral activity of curcumin, by entrapping it into nanostructured lipid carriers (NLCs). For this purpose here we describe the preparation and characterization of three kinds of curcumin-loaded NLCs...
February 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28107515/regulatory-mechanisms-underlying-the-expression-of-prolactin-receptor-in-chicken-granulosa-cells
#18
Shenqiang Hu, Raj Duggavathi, David Zadworny
Prolactin (PRL) has both pro- and anti-gonadal roles in the regulation of avian ovarian functions through its interaction with the receptor (PRLR). However, neither the pattern of expression of PRLR nor its regulatory mechanisms during follicle development have been clearly defined. The objective of the present study was to investigate mechanisms of PRLR expression in chicken granulosa cells. Levels of PRLR transcript were highest in the stroma and walls of follicles < 2 mm in diameter and progressively declined with the maturation of follicles...
2017: PloS One
https://www.readbyqxmd.com/read/28105136/arid1a-gene-silencing-reduces-the-sensitivity-of-ovarian-clear-cell-carcinoma-to-cisplatin
#19
Changshuai Lyu, Yinglan Zhang, Xingnan Zhou, Jinghe Lang
In ovarian clear cell carcinoma (OCCC), the mutation rate of the AT-rich interaction domain 1A (ARID1A) gene is 46-57%. However, the effects of ARID1A gene silencing by small interfering RNA (siRNA) on the sensitivity of OCCC to cisplatin have not been investigated. Thus, this study aimed to elucidate the association between ARID1A gene silencing and drug resistance in OCCC. Three pairs of ARID1A gene siRNA fragments (siRNA-1, siRNA-2 and siRNA-3) were designed and transiently transfected into ES2 OCCC cells using RNAi Max reagent...
December 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/28077793/integrated-proteomic-and-n-glycoproteomic-analyses-of-doxorubicin-sensitive-and-resistant-ovarian-cancer-cells-reveal-glycoprotein-alteration-in-protein-abundance-and-glycosylation
#20
Yanlong Ji, Shasha Wei, Junjie Hou, Chengqian Zhang, Peng Xue, Jifeng Wang, Xiulan Chen, Xiaojing Guo, Fuquan Yang
Ovarian cancer is one of the most common cancer among women in the world, and chemotherapy remains the principal treatment for patients. However, drug resistance is a major obstacle to the effective treatment of ovarian cancers and the underlying mechanism is not clear. An increased understanding of the mechanisms that underline the pathogenesis of drug resistance is therefore needed to develop novel therapeutics and diagnostic. Herein, we report the comparative analysis of the doxorubicin sensitive OVCAR8 cells and its doxorubicin-resistant variant NCI/ADR-RES cells using integrated global proteomics and N-glycoproteomics...
January 6, 2017: Oncotarget
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