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https://www.readbyqxmd.com/read/28930811/significance-of-ovarian-endometriosis-on-the-prognosis-of-ovarian-clear-cell-carcinoma
#1
Jeong-Yeol Park, Dae-Yeon Kim, Dae-Shik Suh, Jong-Hyeok Kim, Yong-Man Kim, Young-Tak Kim, Joo-Hyun Nam
INTRODUCTION: The aim of this study was to evaluate the significance of ovarian endometriosis on the prognosis of ovarian clear cell carcinoma (OCCC). METHODS: Patients with OCCC were divided into 2 groups according to the presence of ovarian endometriosis: group 1, no coexisting ovarian endometriosis; group 2, clear cell carcinoma arising from ovarian endometriosis or the presence of ovarian endometriosis elsewhere in the ovary. Clinicopathologic characteristics, disease-free survival (DFS), and overall survival (OS) were compared between the 2 groups...
September 19, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28929490/histological-subtypes-of-ovarian-cancer-associated-with-parity-and-breastfeeding-in-the-prospective-million-women-study
#2
Kezia Gaitskell, Jane Green, Kirstin Pirie, Isobel Barnes, Carol Hermon, Gillian K Reeves, Valerie Beral
Ovarian cancer risk is known to be reduced amongst women who have had children, but reported associations with breastfeeding are varied. Few studies have had sufficient power to explore reliably these associations by tumour histotype. In a prospective study of 1.1 million UK women, 8719 developed ovarian cancer during follow-up. Cox regression yielded adjusted relative risks (RRs) overall and by tumour histotype amongst women with different childbearing patterns. Nulliparous women had a 24% greater ovarian cancer risk than women with one child, with significant heterogeneity by histotype (p=0...
September 20, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28926955/identification-of-novel-bisbenzimidazole-derivatives-as-anticancer-vacuolar-h%C3%A2-%C2%BA-atpase-inhibitors
#3
Renukadevi Patil, Arpita Kulshrestha, Anjali Tikoo, Sara Fleetwood, Gajendra Katara, Bala Kolli, William Seibel, Alice Gilman-Sachs, Shivaputra A Patil, Kenneth D Beaman
The vacuolar (H⁺)-ATPases (V-ATPases) are a family of ATP-driven proton pumps and they have been associated with cancer invasion, metastasis, and drug resistance. Despite the clear involvement of V-ATPases in cancer, the therapeutic use of V-ATPase-targeting small molecules has not reached human clinical trials to date. Thus, V-ATPases are emerging as important targets for the identification of potential novel therapeutic agents. We identified a bisbenzimidazole derivative (V) as an initial hit from a similarity search using four known V-ATPase inhibitors (I-IV)...
September 16, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28920005/the-frequency-of-neoantigens-per-somatic-mutation-rather-than-overall-mutational-load-or-number-of-predicted-neoantigens-per-se-is-a-prognostic-factor-in-ovarian-clear-cell-carcinoma
#4
Hirokazu Matsushita, Kosei Hasegawa, Katsutoshi Oda, Shogo Yamamoto, Akira Nishijima, Yuichi Imai, Kayo Asada, Yuji Ikeda, Takahiro Karasaki, Keiichi Fujiwara, Hiroyuki Aburatani, Kazuhiro Kakimi
Neoantigens derived from tumor-specific somatic mutations are excellent targets for anti-tumor immune responses. In ovarian clear cell carcinoma (OCCC), checkpoint blockade yields durable responses in a subset of patients. To approach the question of why only some patients respond, we first investigated neoantigen loads and immune signatures using exome sequencing and expression array data for 74 OCCC patients treated conventionally. Neither the number of missense mutations nor total predicted neoantigens assessed in the tumor correlated with clinical outcomes...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28915830/biological-effects-of-combined-resveratrol-and-vitamin-d3-on-ovarian-tissue
#5
Francesca Uberti, Vera Morsanuto, Silvio Aprile, Sabrina Ghirlanda, Ian Stoppa, Andrea Cochis, Giorgio Grosa, Lia Rimondini, Claudio Molinari
BACKGROUND: Resveratrol (3,5,4'-trihydroxy-trans-stilbene) is a natural antioxidant polyphenol able to exert a wide range of biological effect on several tissues. Despite its important beneficial properties, it has a low water solubility, which limits its therapeutic applications in humans. Resveratrol also acts as a phytoestrogen that modulates estrogen receptor (ER)-mediated transcription. In addition, it has been shown that ovarian tissues benefit greatly from vitamin D3, which exerts its beneficial effects through VDR receptors...
September 15, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28888784/malignant-ascites-determine-the-transmesothelial-invasion-of-ovarian-cancer-cells
#6
Justyna Mikuła-Pietrasik, Paweł Uruski, Sebastian Szubert, Dariusz Szpurek, Stefan Sajdak, Andrzej Tykarski, Krzysztof Książek
The exact role of malignant ascites in the development of intraperitoneal ovarian cancer metastases remains unclear. In this report we sought to establish if ascites can determine the efficiency of transmesothelial invasion of ovarian cancer cells, and, if so, whether the fluid generated by highly aggressive serous and undifferentiated tumors will promote the invasion more effectively than ascites from less aggressive clear cell and endometrioid cancers. The study showed that the invasion of ovarian cancer cells (SKOV-3 and primary cancer cells) across monolayered peritoneal mesothelial cells was elevated upon mesothelial cell exposure to fluid produced by serous and undifferentiated cancers, as compared with cells subjected to ascites from clear cell and endometrioid tumors...
September 6, 2017: International Journal of Biochemistry & Cell Biology
https://www.readbyqxmd.com/read/28888422/exome-sequencing-landscape-analysis-in-ovarian-clear-cell-carcinoma-shed-light-on-key-chromosomal-regions-and-mutation-gene-networks
#7
Ryusuke Murakami, Noriomi Matsumura, J B Brown, Koichiro Higasa, Takanobu Tsutsumi, Mayumi Kamada, Hisham Abou-Taleb, Yuko Hosoe, Sachiko Kitamura, Ken Yamaguchi, Kaoru Abiko, Junzo Hamanishi, Tsukasa Baba, Masafumi Koshiyama, Yasushi Okuno, Ryo Yamada, Fumihiko Matsuda, Ikuo Konishi, Masaki Mandai
Previous studies have reported genome-wide mutation profile analyses in ovarian clear cell carcinomas (OCCCs). This study aims to identify specific novel molecular alterations by combined analyses of somatic mutation and copy number variation. We performed whole exome sequencing of 39 OCCC samples with 16 matching blood tissue samples. Four hundred twenty-six genes had recurrent somatic mutations. Among the 39 samples, ARID1A (62%) and PIK3CA (51%) were frequently mutated, as were genes such as KRAS (10%), PPP2R1A (10%), and PTEN (5%), that have been reported in previous OCCC studies...
October 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28882592/polyunsaturated-fatty-acids-induce-ovarian-cancer-cell-death-through-ros-dependent-map-kinase-activation
#8
Aiko Tanaka, Akane Yamamoto, Kaeko Murota, Toshifumi Tsujiuchi, Masao Iwamori, Nobuyuki Fukushima
Free fatty acids not only play a role in cell membrane construction and energy production but also exert diverse cellular effects through receptor and non-receptor mechanisms. Moreover, epidemiological and clinical studies have so far suggested that polyunsaturated fatty acids (PUFAs) could have health benefits and the advantage as therapeutic use in cancer treatment. However, the underlying mechanisms of PUFA-induced cellular effects remained to be cleared. Here, we examined the effects of ω-3 and ω-6 PUFAs on cell death in ovarian cancer cell lines...
September 4, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28872817/carboplatin-loaded-raman-encoded-chitosan-coated-silver-nanotriangles-as-multimodal-traceable-nanotherapeutic-delivery-systems-and-ph-reporters-inside-human-ovarian-cancer-cells
#9
Monica Potara, Timea Nagy-Simon, Ana Maria Craciun, Sorina Suarasan, Emilia Licarete, Florica Imre-Lucaci, Simion Astilean
Ovarian cancer is a common cause of cancer death in women and is associated with the highest mortality rates of all gynecological malignancies. Carboplatin (CBP) is the most used cytotoxic agent in the treatment of ovarian cancer. Herein, we design and assess a CBP nanotherapeutic delivery system which allows combinatorial functionalities of chemotherapy, pH sensing, and multimodal traceable properties inside live NIH:OVCAR-3 ovarian cancer cells. In our design, a pH-sensitive Raman reporter, 4-mercaptobenzoic acid (4MBA) is anchored onto the surface of chitosan-coated silver nanotriangles (chit-AgNTs) to generate a robust surface-enhanced Raman scattering (SERS) traceable system...
September 13, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28871344/tubal-ligation-and-ovarian-cancer-risk-in-african-american-women
#10
Chrissy McNamara, Sarah E Abbott, Elisa V Bandera, Bo Qin, Lauren C Peres, Fabian Camacho, Patricia G Moorman, Anthony J Alberg, Jill S Barnholtz-Sloan, Melissa Bondy, Michele L Cote, Ellen Funkhouser, Edward S Peters, Ann G Schwartz, Joellen M Schildkraut, Paul Terry
PURPOSE: Tubal ligation has been associated with reduced risk of epithelial ovarian cancer (EOC) in studies of primarily white women, but less is known about the association in African American (AA) women. We sought to evaluate the associations among 597 invasive ovarian cancer cases and 742 controls of AA descent recruited from the African American Cancer Epidemiology Study, a population-based case-control study in 11 geographical areas in the US. METHODS: Multivariable logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (CI) adjusted for potentially confounding factors...
September 4, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28871275/radiation-treatment-in-women-with-ovarian-cancer-past-present-and-future
#11
REVIEW
Emma C Fields, William P McGuire, Lilie Lin, Sarah M Temkin
Ovarian cancer is the most lethal of the gynecologic cancers, with 5-year survival rates less than 50%. Most women present with advanced stage disease as the pattern of spread is typically with dissemination of malignancy throughout the peritoneal cavity prior to development of any symptoms. Prior to the advent of platinum-based chemotherapy, radiotherapy was used as adjuvant therapy to sterilize micrometastatic disease. The evolution of radiotherapy is detailed in this review, which establishes radiotherapy as an effective therapy for women with micrometastatic disease in the peritoneal cavity after surgery, ovarian clear cell carcinoma, focal metastatic disease, and for palliation of advanced disease...
2017: Frontiers in Oncology
https://www.readbyqxmd.com/read/28870888/cell-secreted-vesicles-containing-micrornas-as-regulators-of-gamete-maturation
#12
Juliano C da Silveira, Ana Clara F C M de Avila, Hannah L Garrett, Jason Bruemmer, Quinton Winger, Gerrit Bouma
Mammalian gamete maturation requires extensive signaling between germ cells and their surrounding somatic cells. In the ovary, theca cells, mural granulosa cells, cumulus cells and the oocyte all secrete factors throughout follicle growth and maturation that are critical for ovulation of a high quality oocyte with the competence to develop into an embryo. Similarly, maturation of sperm occurs as it transits the epididymis during which epididymal epithelium and sperm exchange secretory factors that are required for sperm to gain motility and fertility...
September 4, 2017: Journal of Endocrinology
https://www.readbyqxmd.com/read/28863045/perineal-talc-use-and-ovarian-cancer-a-systematic-review-and-meta-analysis
#13
Ross Penninkilampi, Guy D Eslick
BACKGROUND: It has been posited that there is an association between perineal talc use and the incidence of ovarian cancer. To date, this has only been explored in observational studies. OBJECTIVES: To perform a meta-analysis to evaluate the association between perineal talc use and risk of ovarian cancer. METHODS: Studies were identified using six electronic databases. Observational studies involving at least 50 cases of ovarian cancer were eligible for inclusion...
August 31, 2017: Epidemiology
https://www.readbyqxmd.com/read/28862203/utility-of-cell-block-to-detect-malignancy-in-fluid-cytology-adjunct-or-necessity
#14
Sumedha Dey, Dipanwita Nag, Ayandip Nandi, Ranjana Bandyopadhyay
AIM OF THE STUDY: Cell block (CB) technique when supplemented with conventional smear, provides increased cellularity, preservation of architectural pattern with excellent morphology, and a clear background. We compare the utility of CB technique compared to conventional smear in detection of malignancy in serous effusions. MATERIALS AND METHODS: An institution-based observational and analytical study was carried out over 1 year on 50 patients with effusions. The residual amount of centrifuged deposit after preparation of conventional smear was mixed with 10% alcohol-formalin solution, and CBs were prepared...
July 2017: Journal of Cancer Research and Therapeutics
https://www.readbyqxmd.com/read/28860440/-a-retrospective-analysis-of-systematic-lymphadenectomy-for-loco-regional-pt1-epithelial-ovarian-cancer
#15
Rieko Okubo, Kimihiko Ito, Shinichi Nakatsuka, Hitoshi Watanabe, Taro Yagi, Chihiro Odani, Hitomi Ono, Kanoko Shimoji, Mio Nakagawa, Mayako Goto, Tomohiko Tsuruta, Kensuke Hori, Lena Tashima
BACKGROUND: The incidence of lymph node metastasis in pT1 epithelial ovarian cancer is between 5% and 21%. Most cases with lymph node metastasis are those of serous carcinoma; it is relatively rare in mucinous carcinoma. Therefore, there is a recent trend to omit systematic lymphadenectomy in early stage mucinous carcinoma. The purpose of this study was to verify whether the omission of systematic lymphadenectomy in mucinous carcinoma is oncologically safe. METHODS: We reviewed all pT1 epithelial ovarian cancer cases that were treated in our hospital between January 2002 and December 2015...
August 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28859612/differential-expression-of-estrogen-receptor-subtypes-and-variants-in-ovarian-cancer-effects-on-cell-invasion-proliferation-and-prognosis
#16
Karen K L Chan, Michelle K Y Siu, Yu-Xin Jiang, Jing-Jing Wang, Yan Wang, Thomas H Y Leung, Stephanie S Liu, Annie N Y Cheung, Hextan Y S Ngan
BACKGROUND: Due to the presence of both classical estrogen receptor (ERα) and another ER subtype (ERβ) in ovarian cancer, hormonal treatment is an attractive option. However, response to tamoxifen in ovarian cancer is modest. The presence of ERβ variants further complicated the issue. We have recently shown that specifically targeting ER subtypes using selective ER modulators showed opposing functions of ER subtypes on cell growth. In the present study, the clinical significance of ERα and ERβ variants (β1, β2 and β5) and the functional effects of ERβ2 and ERβ5 in ovarian cancer was investigated...
August 31, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28857608/proteomic-alterations-of-fibroblasts-induced-by-ovarian-cancer-cells-reveal-potential-cancer-targets
#17
X Y Zhang, S S Hong, M Zhang, Q Q Cai, M X Zhang, C J Xu
The common spread pattern of ovarian cancer is peritoneal implantation. The growth of the shed ovarian cancer cells in the peritoneal cavity is closely related to the tumor microenvironment. Cancer-associated fibroblasts are vital in the tumor microenvironment. It is not clearly defined that the protein expression alters during the activating process of fibroblasts. This study detected the protein alterations in fibroblasts induced by ovarian cancer cells and explored the potential biological relevance through two-dimensional gel electrophoresis and mass spectrometry...
August 31, 2017: Neoplasma
https://www.readbyqxmd.com/read/28846697/prognostic-relevance-of-a-t-type-calcium-channels-gene-signature-in-solid-tumours-a-correlation-ready-for-clinical-validation
#18
Lorenzo Fornaro, Caterina Vivaldi, Dong Lin, Hui Xue, Alfredo Falcone, Yuzhuo Wang, Francesco Crea, Martin D Bootman
BACKGROUND: T-type calcium channels (TTCCs) mediate calcium influx across the cell membrane. TTCCs regulate numerous physiological processes including cardiac pacemaking and neuronal activity. In addition, they have been implicated in the proliferation, migration and differentiation of tumour tissues. Although the signalling events downstream of TTCC-mediated calcium influx are not fully elucidated, it is clear that variations in the expression of TTCCs promote tumour formation and hinder response to treatment...
2017: PloS One
https://www.readbyqxmd.com/read/28835089/-a-case-of-everolimus-maintenance-therapy-of-primary-platinum-resistant-ovarian-clear-cell-carcinoma
#19
Z Yu, H R Liu, K Jiang
No abstract text is available yet for this article.
August 23, 2017: Zhonghua Zhong Liu za Zhi [Chinese Journal of Oncology]
https://www.readbyqxmd.com/read/28833087/menstrual-pain-and-risk-of-epithelial-ovarian-cancer-results-from-the-ovarian-cancer-association-consortium
#20
Ana Babic, Holly R Harris, Allison F Vitonis, Linda J Titus, Susan J Jordan, Penelope M Webb, Harvey A Risch, Mary Anne Rossing, Jennifer A Doherty, Kristine Wicklund, Marc T Goodman, Francesmary Modugno, Kirsten B Moysich, Roberta Ness, Susanne K Kjaer, Joellen Schildkraut, Andrew Berchuck, Celeste L Pearce, Anna H Wu, Daniel W Cramer, Kathryn L Terry
Menstrual pain, a common gynecological condition, has been associated with increased risk of ovarian cancer in some, but not all studies. Furthermore, potential variations in the association between menstrual pain and ovarian cancer by histologic subtype have not been adequately evaluated due to lack of power. We assessed menstrual pain using either direct questions about having experienced menstrual pain, or indirect questions about menstrual pain as indication for use of hormones or medications. We used multivariate logistic regression to calculate the odds ratio (OR) for the association between severe menstrual pain and ovarian cancer, adjusting for potential confounders, and multinomial logistic regression to calculate odds ratios for specific histologic subtypes...
August 22, 2017: International Journal of Cancer. Journal International du Cancer
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