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https://www.readbyqxmd.com/read/28214405/our-faustian-pact-with-the-digital-world
#1
Catriona M McNeil, Paul R Harnett
No abstract text is available yet for this article.
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28211501/high-resolution-3d-imaging-of-whole-organ-after-clearing-taking-a-new-look-at-the-zebrafish-testis
#2
Maxence Frétaud, Laurie Rivière, Élodie De Job, Stéphanie Gay, Jean-Jacques Lareyre, Jean-Stéphane Joly, Pierre Affaticati, Violette Thermes
Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications in applied and basic research. Many studies have focused on 2D images, which is time consuming and implies extrapolation of results. Three-dimensional imaging of whole organs recently became an important challenge to better understand their architecture and allow cell enumeration. Several protocols have thus been developed to enhance sample transparency, a limiting step for imaging large biological samples...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207883/application-of-an-optimized-flow-cytometry-based-quantification-of-platelet-activation-pact-monitoring-platelet-activation-in-platelet-concentrates
#3
Cécile H Kicken, Mark Roest, Yvonne M C Henskens, Bas de Laat, Dana Huskens
BACKGROUND: Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist induced platelet activation (PACT) to a labor, time and more cost-efficient test. Currently the quality of PCs is only monitored by visual inspection, because available assays are unreliable or too laborious for use in a clinical transfusion laboratory...
2017: PloS One
https://www.readbyqxmd.com/read/28178523/the-mitochondrial-rhomboid-protease-parl-is-regulated-by-pdk2-to-integrate-mitochondrial-quality-control-and-metabolism
#4
Guang Shi, G Angus McQuibban
Mitochondrial quality control (MQC) systems are essential for mitochondrial health and normal cellular function. Dysfunction of MQC is emerging as a central mechanism for the pathogenesis of various diseases, including Parkinson's disease. The mammalian mitochondrial rhomboid protease, PARL, has been proposed as a regulator of PINK1/PARKIN-mediated mitophagy, which is an essential component of MQC. PARL undergoes an N-terminal autocatalytic cleavage (β cleavage), which is required for efficient mitophagy...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28167698/adar1-and-pact-contribute-to-efficient-translation-of-transcripts-containing-hiv-1-trans-activating-response-tar-element
#5
Evelyn Chukwurah, Indhira Handy, Rekha C Patel
Human immunodeficiency virus type 1 (HIV-1) has evolved various measures to counter the host cell's innate antiviral response during the course of infection. Interferon (IFN)-stimulated gene products are produced following HIV-1 infection to limit viral replication, but viral proteins and RNAs counteract their effect. One such mechanism is specifically directed against the IFN-induced Protein Kinase R (PKR), which is centrally important to the cellular antiviral response. In the presence of viral RNAs, PKR is activated and phosphorylates the translation initiation factor, eIF2α...
February 6, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28139694/elevated-temperature-induced-acceleration-of-pact-clearing-process-of-mouse-brain-tissue
#6
Tingting Yu, Yisong Qi, Jingtan Zhu, Jianyi Xu, Hui Gong, Qingming Luo, Dan Zhu
Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffers from long processing time. Previous studies indicated that increasing temperature can speed up the clearing. In this work, we aim to systematacially and quantitatively study this influence based on PACT with graded increase of temperatures...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129958/cell-based-therapeutics-making-a-faustian-pact-with-biology
#7
REVIEW
Daniel J Woodsworth, Robert A Holt
The diversity and specialization found in biological molecules, pathways, and cells is staggering, and should be exploited for therapeutic use. Through evolution these biological systems have attained a level of functionality that would be impossible to recapitulate with de novo assembly. To adapt these systems for therapeutic applications it will be often necessary to re-engineer molecules and pathways to yield novel sensory, control, and effector modules for insertion into existing, specialized cellular chassis...
January 24, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28128927/ru-ii-complex-based-dna-photocleaver-having-intense-absorption-in-the-phototherapeutic-window
#8
Yangyang Zhang, Qianxiong Zhou, Na Tian, Chao Li, Xuesong Wang
Ru(II)-complex-based DNA photocleavers have been extensively studied for their potential application in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT). However, their MLCT absorption maxima are generally shorter than 600 nm, limiting PDT/PACT application severely. In this work, by incorporating a 5-chloro-8-oxyquinolate-based noninnocent ligand into a merocyanine scaffold Cl-7-IVQ, we obtained a new Ru complex of this ligand, [Ru(bpy)2(Cl-7-IVQ)](2+), which has intense absorption in the window 600-700 nm and enables an efficient (•)OH-mediated DNA photocleavage...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28121497/effect-of-photodynamic-antimicrobial-chemotherapy-on-mono-and-multi-species-cariogenic-biofilms-a-literature-review
#9
Maria Tayara Marques de Freitas, Talyta Teixeira Soares, Maria Gerusa Brito Aragão, Ramille Araújo Lima, Simone Duarte, Iriana Carla Junqueira Zanin
OBJECTIVE: The aim of this literature review is to study the effect of photodynamic antimicrobial chemotherapy (PACT) on mono and multi-species cariogenic biofilms. METHODS: To this purpose, the database, PubMed, was searched using the descriptors, photodynamic therapy, antimicrobial photodynamic chemotherapy, and photoinactivation, associated with the mandatory presence of the word biofilm. A total of 98 references published from 2003 to 2016 were selected. Moreover, literature reviews (15), investigations that did not have biofilms related to dental caries (65), and those that did not have Streptococcus mutans count as an outcome (7) were excluded, yielding a final amount of 11 publications...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28112705/antibiotics-alone-for-uncomplicated-acute-appendicitis-in-high-operative-risk-adult-patients-analytical-review-of-rcts-and-proposal-of-evidence-based-treatment-decision
#10
Hariscine Keng Abongwa, G Cervellin, A Tarasconi, G Perrone, G Baiocchi, N Portolani, F Catena
BACKGROUND: Clinical trials have so far shown controversial results as regards the standard of care for treating uncomplicated acute appendicitis (uC-AA). High operational risk adult patients (HORAP) could represent selected patients where primary antibiotic conservative therapy (pACT or A) could be indicated. METHODS: We carried a comprehensive search of the PubMed searching engine in the English language scientific literature from 1995 to 2015, using medical subject headings "antibiotics", "uncomplicated appendicitis", "appendicectomy", "conservative treatment", "surgery" and "randomized clinical trial"...
January 16, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28106370/redox-active-cation-intercalation-deintercalation-in-two-dimensional-layered-mno2-nanostructures-for-high-rate-electrochemical-energy-storage
#11
Pan Xiong, Renzhi Ma, Nobuyuki Sakai, Xueyin Bai, Shen Li, Takayoshi Sasaki
Two-dimensional (2D) layered materials with high intercalation pseudocapacitance have long been investigated for Li+-ion-based electrochemical energy storage. By contrast, the exploration of guest ions other than Li+ has been limited, although promising. The present study investigate the intercalation/deintercalation behaviors of various metal ions in 2D layered MnO2 with various interlayer distances, K-birnessite nanobelt (K-MnO2), its protonated form (H-MnO2), and a freeze-dried sample of exfoliated nanosheets...
January 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28101405/deep-tissue-photoacoustic-computed-tomography-with-a-fast-and-compact-laser-system
#12
Depeng Wang, Yuehang Wang, Weiran Wang, Dandan Luo, Upendra Chitgupi, Jumin Geng, Yang Zhou, Lidai Wang, Jonathan F Lovell, Jun Xia
Photoacoustic computed tomography (PACT) holds great promise for biomedical imaging, but wide-spread implementation is impeded by the bulkiness of flash-lamp-pumped laser systems, which typically weigh between 50 - 200 kg, require continuous water cooling, and operate at a low repetition rate. Here, we demonstrate that compact lasers based on emerging diode technologies are well-suited for preclinical and clinical PACT. The diode-pumped laser used in this study had a miniature footprint (13 × 14 × 7 cm(3)), weighed only 1...
January 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/28063848/challenges-with-implementing-a-patient-centered-medical-home-model-for-women-veterans
#13
Emmeline Chuang, Julian Brunner, Selene Mak, Alison B Hamilton, Ismelda Canelo, Jill Darling, Lisa V Rubenstein, Elizabeth M Yano
BACKGROUND: The Veterans Health Administration (VA) Patient Aligned Care Team (PACT) initiative aims to ensure that all patients receive care consistent with medical home principles. Women veterans' unique care needs and minority status within the VA pose challenges to delivery of equitable, comprehensive primary care for this population. Currently, little is known about whether and/or how PACT should be tailored to better meet women veteran needs. METHODS: In 2014, we conducted semistructured interviews with 73 primary care providers and staff to examine facilitators and barriers encountered in providing PACT-principled care to women veterans...
January 4, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28063245/dosing-algorithms-for-vitamin-k-antagonists-across-vkorc1-and-cyp2c9-genotypes
#14
Ekaterina V Baranova, Talitha I Verhoef, Georgia Ragia, Saskia Le Cessie, Folkert W Asselbergs, Anthonius de Boer, Vangelis G Manolopoulos, Anke H Maitland-van der Zee
BACKGROUND: The multicenter, single-blind, randomized EU-PACT trial compared safety and efficacy of genotype-guided and non-genetic dosing algorithms for acenocoumarol and phenprocoumon in patients with atrial fibrillation or deep venous thrombosis. The trial showed no differences in the primary outcome between the two dosing strategies. OBJECTIVES: To explore possible reasons for the lack of differences between trial arms this secondary analysis of EU-PACT data evaluated the performance of both dosing algorithms across VKORC1-CYP2C9 genetic sub-groups...
January 7, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28048581/su-c-204-06-monte-carlo-dose-calculation-for-kilovoltage-x-ray-psoralen-activated-cancer-therapy-x-pact-preliminary-results
#15
S Mein, R Gunasingha, M Nolan, M Oldham, J Adamson
PURPOSE: X-PACT is an experimental cancer therapy where kV x-rays are used to photo-activate anti-cancer therapeutics through phosphor intermediaries (phosphors that absorb x-rays and re-radiate as UV light). Clinical trials in pet dogs are currently underway (NC State College of Veterinary Medicine) and an essential component is the ability to model the kV dose in these dogs. Here we report the commissioning and characterization of a Monte Carlo (MC) treatment planning simulation tool to calculate X-PACT radiation doses in canine trials...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047541/we-fg-bra-01-cancer-treatment-utilizing-photo-activation-of-psoralen-with-kv-x-rays
#16
M Oldham, S Yoon, B Meng, Z Fathi, W Beyer, J Adamson, D Alcorta, T Osada, K Lyerly, M Dewhirst, P Fecci, H Walder, N Spector
PURPOSE: This work investigates X-PACT (X-ray Psoralen Activated Cancer Therapy): a new approach for the treatment of cancer. X-PACT utilizes psoralen, a potent anti-cancer therapeutic with immunogenic anti-cancer potential. Psoralen therapies have been limited due to the requirement for psoralen activation by UVA light. X-PACT solves this challenge by activating psoralen with UV light emitted from novel non-tethered phosphors (co-incubated with psoralen) that absorb x-rays and reradiate (phosphoresce) at UV wavelengths...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28027338/effect-of-an-intensive-outpatient-program-to-augment-primary-care-for-high-need-veterans-affairs-patients-a-randomized-clinical-trial
#17
Donna M Zulman, Christine Pal Chee, Stephen C Ezeji-Okoye, Jonathan G Shaw, Tyson H Holmes, James S Kahn, Steven M Asch
Importance: Many organizations are adopting intensive outpatient care programs for high-need patients, yet little is known about their effectiveness in integrated systems with established patient-centered medical homes. Objective: To evaluate how augmenting the Veterans Affairs (VA) medical home (Patient Aligned Care Teams [PACT]) with an Intensive Management program (ImPACT) influences high-need patients' costs, health care utilization, and experience. Design, Setting, and Participants: Randomized clinical trial at a single VA facility...
February 1, 2017: JAMA Internal Medicine
https://www.readbyqxmd.com/read/28007226/role-expansion-on-interprofessional-primary-care-teams-barriers-of-role-self-efficacy-among-clinical-associates
#18
Karleen F Giannitrapani, Lynn Soban, Alison B Hamilton, Hector Rodriguez, Alexis Huynh, Susan Stockdale, Elizabeth M Yano, Lisa V Rubenstein
BACKGROUND: Interprofessional team-based models of primary care that expand the role of clinical associates (CAs) are increasingly adopted in primary care practices. In this study we query team members of a newly implemented patient centered medical home (PCMH) to identify facilitators and barriers of occupational role self-efficacy, a belief of possessing the capacity to execute their new team based role effectively. METHODS: 79 key informants, members of primary care teams at six Veterans Health Administration (VA) clinics, were interviewed to assess their experiences with implementing expanded roles for CAs...
December 2016: Healthcare
https://www.readbyqxmd.com/read/27992949/age-stratified-outcome-of-genotype-guided-dosing-algorithm-for-acenocoumarol-and-phenprocoumon
#19
Yumao Zhang, Anthonius de Boer, Talitha I Verhoef, Felix Jm van der Meer, Saskia Le Cessie, Vangelis G Manolopoulos, Anke H Maitland-van der Zee
BACKGROUND: Age seemed to affect the interaction between coumarins and genotype in the acenocoumarol and phenprocoumon arm of the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial. OBJECTIVES: To investigate the effect of genotype-guided dosing stratified by age and the potential factors causing a difference. PATIENTS/METHODS: Data from the acenocoumarol/phenprocoumon arm of the EU-PACT trial was used. The percentage of time below, above and in the therapeutic range (TTR) during the initial 12 weeks of therapy were compared between the genotype-guided group and the control group among younger (<75 years) and older (≥75 years) patients using independent t-test and adjust for sex, height, weight and co-medications using linear regression...
December 19, 2016: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/27980029/risk-stratification-for-opioid-misuse-in-children-adolescents-and-young-adults-a-quality-improvement-project
#20
Rachel Thienprayoon, Kelly Porter, Michelle Tate, Marshall Ashby, Mark Meyer
BACKGROUND: The Pediatric Palliative and Comfort Care Team (PACT) at Cincinnati Children's Hospital Medical Center (CCHMC) provides opioids to a large population of patients in the ambulatory setting. Before this project, PACT had no reliable system to risk stratify patients for opioid misuse. METHODS: The global aim was safe opioid prescribing by the palliative care team. The specific, measurable, achievable, realistic, and timely aim was as follows: "In patients who present for follow up with PACT, we will use the "opioid bundle" to increase risk stratification for opioid misuse from 0% to 90% over 5 months...
January 2017: Pediatrics
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