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https://www.readbyqxmd.com/read/28818924/u-s-mexico-water-pact-aims-for-a-greener-colorado-delta
#1
Warren Cornwall
No abstract text is available yet for this article.
August 18, 2017: Science
https://www.readbyqxmd.com/read/28814505/the-molecular-architecture-of-the-yeast-spindle-pole-body-core-determined-by-bayesian-integrative-modeling
#2
Shruthi Viswanath, Massimiliano Bonomi, Seung Joong Kim, Vadim A Klenchin, Keenan C Taylor, King C Yabut, Neil T Umbreit, Heather A Van Epps, Janet Meehl, Michele H Jones, Daniel Russel, Javier A Velazquez-Muriel, Mark Winey, Ivan Rayment, Trisha N Davis, Andrej Sali, Eric G Muller
Microtubule organizing centers (MTOCs) form, anchor and stabilize the polarized network of microtubules in a cell. The central MTOC is the centrosome that duplicates during the cell cycle and during mitosis assembles a bipolar spindle to capture and segregate sister chromatids. Yet, despite their importance in cell biology, the physical structure of MTOCs is poorly understood. Here we determine the molecular architecture of the core of the yeast spindle pole body (SPB) by Bayesian integrative structure modeling based on in vivo FRET, small-angle X-ray scattering (SAXS), X-ray crystallography, electron microscopy and two-hybrid analysis...
August 16, 2017: Molecular Biology of the Cell
https://www.readbyqxmd.com/read/28806373/patient-aligned-care-team-engagement-to-connect-veterans-experiencing-homelessness-with-appropriate-health-care
#3
Adi V Gundlapalli, Andrew Redd, Daniel Bolton, Megan E Vanneman, Marjorie E Carter, Erin Johnson, Matthew H Samore, Jamison D Fargo, Thomas P O'Toole
BACKGROUND: Veterans experiencing homelessness frequently use emergency and urgent care (ED). OBJECTIVE: To examine the effect of a Patient-aligned Care Team (PACT) model tailored to the unique needs of Veterans experiencing homelessness (H-PACT) on frequency and type of ED visits in Veterans Health Administration (VHA) medical facilities. RESEARCH DESIGN: During a 12-month period, ED visits for 3981 homeless Veterans enrolled in (1) H-PACT at 20 VHA medical centers (enrolled) were compared with those of (2) 24,363 homeless Veterans not enrolled in H-PACT at the same sites (nonenrolled), and (3) 23,542 homeless Veterans at 12 non-H-PACT sites (usual care) using a difference-in-differences approach...
September 2017: Medical Care
https://www.readbyqxmd.com/read/28805422/stakeholder-perspectives-on-a-toolkit-to-enhance-caregiver-participation-in-community-based-child-mental-health-services
#4
Rachel Haine-Schlagel, Molly Mechammil, Lauren Brookman-Frazee
Client engagement in services is a critical element of effective community-based child and family mental health service delivery. Caregiver engagement is particularly important, as caregivers often serve as gatekeepers to child mental health care and typically must consent for services, facilitate service attendance, and are often the target of intervention themselves. Unfortunately, caregiver engagement has been identified as a significant challenge in community-based child mental health services. To address this gap, the Parent And Caregiver Active Participation Toolkit (PACT), which includes therapist training and participation tools for caregivers and therapists, was developed...
August 2017: Psychological Services
https://www.readbyqxmd.com/read/28760879/pact-facilitates-rna-induced-activation-of-mda5-by-promoting-mda5-oligomerization
#5
Pak-Yin Lui, Lok-Yin Roy Wong, Ting-Hin Ho, Shannon Wing Ngor Au, Chi-Ping Chan, Kin-Hang Kok, Dong-Yan Jin
MDA5 is a RIG-I-like cytoplasmic sensor of dsRNA and certain RNA viruses, such as encephalomyocarditis virus, for the initiation of the IFN signaling cascade in the innate antiviral response. The affinity of MDA5 toward dsRNA is low, and its activity becomes optimal in the presence of unknown cellular coactivators. In this article, we report an essential coactivator function of dsRNA-binding protein PACT in mediating the MDA5-dependent type I IFN response. Virus-induced and polyinosinic-polycytidylic acid-induced activation of MDA5 were severely impaired in PACT-knockout cells and attenuated in PACT-knockdown cells, but they were potentiated when PACT was overexpressed...
July 31, 2017: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/28745893/microbiota-host-transgenomic-metabolism-bioactive-molecules-from-the-inside
#6
Silvia Turroni, Patrizia Brigidi, Andrea Cavalli, Marco Candela
Molecular factors from the gut microbiota provide the host with the right metabolic, immunological, and neurological components to support health and well-being. However, certain circumstances can rupture the mutualistic pact with our intestinal counterpart, pushing the gut microbiome toward a dysbiotic layout, where microbiome-derived molecules may contribute to a disease state. We are now beginning to understand the microbiota-host co-regulated pathways underlying these processes, paving the way for a new era of rational piloting of the gut microbiome functions, through the design of a new generation of microbiome-targeting drugs...
August 3, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28738685/assessing-the-effect-of-the-vha-pcmh-model-on-utilization-patterns-among-veterans-with-ptsd
#7
Ian Randall, Charles Maynard, Gary Chan, Beth Devine, Chris Johnson
OBJECTIVES: The Veterans Health Administration (VHA) implemented a patient-centered medical home (PCMH)-based Patient Aligned Care Teams (PACT) model in 2010. We examined its effects on the utilization of health services among US veterans with posttraumatic stress disorder (PTSD). STUDY DESIGN: We analyzed VHA clinical and administrative data to conduct an interrupted time series study. Encounter-level data were obtained for the period of April 1, 2005, through March 31, 2014...
May 2017: American Journal of Managed Care
https://www.readbyqxmd.com/read/28728966/advances-and-perspectives-in-tissue-clearing-using-clarity
#8
REVIEW
Kristian H Reveles Jensen, Rune W Berg
CLARITY is a tissue clearing method, which enables immunostaining and imaging of large volumes for 3D-reconstruction. The method was initially time-consuming, expensive and relied on electrophoresis to remove lipids to make the tissue transparent. Since then several improvements and simplifications have emerged, such as passive clearing (PACT) and methods to improve tissue staining. Here, we review advances and compare current applications with the aim of highlighting needed improvements as well as aiding selection of the specific protocol for use in future investigations...
July 17, 2017: Journal of Chemical Neuroanatomy
https://www.readbyqxmd.com/read/28726549/homeless-veterans-experiences-with-substance-use-recovery-and-treatment-through-photo-elicitation
#9
Samuel F Sestito, Keri L Rodriguez, Shaddy K Saba, James W Conley, Michael A Mitchell, Adam J Gordon
BACKGROUND: Homeless Veterans often have addictions and comorbidities that complicate utilization of longitudinal healthcare services, such as primary care. An understanding of experiences of Veterans enrolled in a Homeless Patient Aligned Care Team (H-PACT) may improve addiction treatment engagement in these settings. We aimed to describe H-PACT Veterans' experiences with substance use (SU), substance use recovery (SUR), and substance use treatment (SUT). METHODS: Homeless Veterans were recruited from a Veteran primary care medical home clinic between September 2014 and March 2015...
July 20, 2017: Substance Abuse
https://www.readbyqxmd.com/read/28723408/in-line-raman-spectroscopic-monitoring-and-feedback-control-of-a-continuous-twin-screw-pharmaceutical-powder-blending-and-tableting-process
#10
Brigitta Nagy, Attila Farkas, Martin Gyürkés, Szofia Komaromy-Hiller, Balázs Démuth, Bence Szabó, Dávid Nusser, Enikő Borbás, György Marosi, Zsombor Kristóf Nagy
The integration of Process Analytical Technology (PAT) initiative into the continuous production of pharmaceuticals is indispensable for reliable production. The present paper reports the implementation of in-line Raman spectroscopy in a continuous blending and tableting process of a three-component model pharmaceutical system, containing caffeine as model active pharmaceutical ingredient (API), glucose as model excipient and magnesium stearate as lubricant. The real-time analysis of API content, blend homogeneity, and tablet content uniformity was performed using a Partial Least Squares (PLS) quantitative method...
July 16, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28706092/development-of-an-intervention-to-support-patients-and-clinicians-with-advanced-lung-cancer-when-considering-systematic-anticancer-therapy-protocol-for-the-pact-study
#11
Despina Anagnostou, Stephanie Sivell, Simon Noble, Jason Lester, Anthony Byrne, Catherine Sampson, Mirella Longo, Annmarie Nelson
INTRODUCTION: Patient-centred care is essential to the delivery of healthcare; however, this necessitates direct patient involvement in clinical decision-making and can be challenging for patients diagnosed with advanced non-small cell lung cancer where there may be misunderstanding of the extent of disease, prognosis and aims of treatment. In this context, decisions are complex and there is a need to balance the risks and benefits, including treatment with palliative intent. The aim of the PACT study is to identify the information and decision support needs of patients, leading to the development of an intervention to support patients with advanced lung cancer when considering treatment options...
July 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28702357/a-numerical-analysis-of-a-semi-dry-coupling-configuration-in-photoacoustic-computed-tomography-for-infant-brain-imaging
#12
Najme Meimani, Nina Abani, Juri Gelovani, Mohammad R N Avanaki
In the application of photoacoustic human infant brain imaging, debubbled ultrasound gel or water is commonly used as a couplant for ultrasonic transducers due to their acoustic properties. The main challenge in using such a couplant is its discomfort for the patient. In this study, we explore the feasibility of a semi-dry coupling configuration to be used in photoacoustic computed tomography (PACT) systems. The coupling system includes an inflatable container consisting of a thin layer of Aqualene with ultrasound gel or water inside of it...
September 2017: Photoacoustics
https://www.readbyqxmd.com/read/28699913/viral-inhibitions-of-pact-induced-rig-i-activation
#13
EDITORIAL
Morgan Brisse, Hinh Ly
No abstract text is available yet for this article.
July 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/28684136/open-innovation-towards-sharing-of-data-models-and-workflows
#14
Daniela J Conrado, Mats O Karlsson, Klaus Romero, Céline Sarr, Justin J Wilkins
Sharing of resources across organisations to support open innovation is an old idea, but which is being taken up by the scientific community at increasing speed, concerning public sharing in particular. The ability to address new questions or provide more precise answers to old questions through merged information is among the attractive features of sharing. Increased efficiency through reuse, and increased reliability of scientific findings through enhanced transparency, are expected outcomes from sharing...
July 3, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28665008/understanding-how-coping-strategies-and-quality-of-life-maintain-hope-in-patients-deliberating-phase-i-trial-participation
#15
Diane A van der Biessen, Peer G van der Helm, Dennis Klein, Simone van der Burg, Ron H Mathijssen, Martijn P Lolkema, Maja J de Jonge
OBJECTIVE: This study aimed to understand how hope and motivation of patients considering phase-I trial participation are affected by psychological factors such as coping strategies and locus of control (LoC), and general well-being as measured by the quality of life (QoL). METHODS: An exploratory cross-sectional study was performed in patients with incurable cancer (N=135) referred to our phase-I unit for the first time. Patients were potentially eligible for phase-I trial participation and participated in our study while deliberating phase-I trial participation...
June 30, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28659157/supporting-medication-discontinuation-provider-preferences-for-interventions-to-facilitate-deprescribing
#16
Amy Linsky, Mark Meterko, Kelly Stolzmann, Steven R Simon
BACKGROUND: One approach to prevent adverse drug events is to discontinue ("deprescribe") medications that are outdated, not indicated, or of limited benefit relative to risk for a particular patient. However, there is little guidance to clinicians about how to integrate the process of deprescribing into the workflow of clinical practice. We sought to determine clinical prescribers' preferences for interventions that would improve their ability to appropriately and proactively discontinue medications...
June 28, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28635056/high-resolution-deep-functional-imaging-of-the-whole-mouse-brain-by-photoacoustic-computed-tomography-in%C3%A2-vivo
#17
Pengfei Zhang, Lei Li, Li Lin, Peng Hu, Junhui Shi, Yun He, Liren Zhu, Yong Zhou, Lihong V Wang
Photoacoustic computed tomography (PACT) is a non-invasive imaging technique offering high contrast, high resolution, and deep penetration in biological tissues. We report a PACT system equipped with a high frequency linear transducer array for mapping the microvascular network of a whole mouse brain with the skull intact and studying its hemodynamic activities. The linear array was scanned in the coronal plane to collect data from different angles, and full-view images were synthesized from the limited-view images in which vessels were only partially revealed...
June 21, 2017: Journal of Biophotonics
https://www.readbyqxmd.com/read/28634830/the-microrna-effector-rna-induced-silencing-complex-in-hidradenitis-suppurativa-a-significant-dysregulation-within-active-inflammatory-lesions
#18
S Hessam, M Sand, M Skrygan, Falk G Bechara
Recently, we could show that the expression levels of the key regulators of the microRNA (miRNA) maturation and transport were dysregulated in inflamed hidradenitis suppurativa (HS) tissue (Heyam et al. in Wiley Interdiscip Rev RNA 6:271-289, 2015). The RNA-induced silencing complex (RISC) is the central element of the miRNA pathway and regulates miRNA formation and function. We investigated the expression of the RISC components, namely transactivation-responsive RNA-binding protein-1 (TRBP1), TRBP2, protein activator (PACT) of the interferon-induced protein kinase R, Argonaute RISC Catalytic Component-1 (AGO1) and Component-2 (AGO2), metadherin, and staphylococcal nuclease and Tudor domain-containing-1 (SND1) in inflamed HS tissue compared to healthy and psoriatic controls by real-time reverse transcription polymerase chain reaction...
June 20, 2017: Archives of Dermatological Research
https://www.readbyqxmd.com/read/28608988/dosing-algorithms-for-vitamin-k-antagonists-across-vkorc1-and-cyp2c9-genotypes-comment
#19
LETTER
T Gaikwad, K Ghosh, S Shetty
No abstract text is available yet for this article.
June 13, 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28604507/visits-to-registered-nurses-an-opportunity-to-increase-contraceptive-access-in-california
#20
Emese C Parker, Kevin Kong, Leslie A Watts, Eleanor B Schwarz, Philip D Darney, Heike Thiel de Bocanegra
BACKGROUND: In 2013, California passed Assembly Bill (A.B.) 2348, approving registered nurses (RNs) to dispense patient self-administered hormonal contraceptives and administer injections of hormonal contraceptives. The Family Planning, Access, Care and Treatment (Family PACT) program, which came into effect in 1997 to expand low-income, uninsured California resident access to contraceptives at no cost, is one program in which qualified RNs can dispense and administer contraceptives. AIMS: The aims of this study were to (a) describe utilization of RN visits within California's Family PACT program and (b) evaluate the impact of RN visits on client birth control acquisition during the first 18 months after implementation of A...
July 2017: Nursing Research
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