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https://www.readbyqxmd.com/read/29235043/effects-of-physical-exercise-on-markers-of-inflammation-in-breast-cancer-patients-during-adjuvant-chemotherapy
#1
Jonna K van Vulpen, Martina E Schmidt, Miranda J Velthuis, Joachim Wiskemann, Andreas Schneeweiss, Roel C H Vermeulen, Nina Habermann, Cornelia M Ulrich, Petra H M Peeters, Elsken van der Wall, Anne M May, Karen Steindorf
PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy. METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue...
December 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29231267/contribution-of-the-two-dsrbm-motifs-to-the-double-stranded-rna-binding-and-protein-interactions-of-pact
#2
Evelyn Chukwurah, Victoria Willingham, Madhurima Singh, David Castillo-Azofeifa, Rekha C Patel
PACT is a stress-modulated activator of protein kinase PKR (protein kinase, RNA activated), which is involved in antiviral innate immune responses and stress-induced apoptosis. Stress-induced phosphorylation of PACT is essential for PACT's increased association with PKR leading to PKR activation, phosphorylation of translation initiation factor eIF2α, inhibition of protein synthesis, and apoptosis. PACT-induced PKR activation is negatively regulated by TRBP (Transactivation response element RNA-binding protein), which dissociates from PACT after PACT phosphorylation in response to stress signals...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227279/drug-eluting-balloon-design-technology-and-clinical-aspects
#3
Meenasree Bukka, Poorna Jyothi Rednam, Mukty Sinha
Drug eluting balloon is a non-stent technology in which an effective homogenous delivery of anti-proliferative drug processed to the vessel wall through inflated balloon. This is done to restore luminal vascularity in order to treat atherosclerosis, in-stent restenosis and reduce risk of late thrombosis without implanting a permanent foreign object. The balloon technology relies on the concept of targeted delivery of drug which helps in rapid healing of vessel wall and prevents the proliferation of smooth muscle cell...
December 11, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/29221859/photodynamic-antimicrobial-chemotherapy-pact-using-toluidine-blue-o-inhibits-the-viability-of-biofilm-produced-by-candida-albicans-at-different-stages-of-development
#4
Ana Paula Pinto, Isabela Bueno Rosseti, Moisés Lopes Carvalho, Bruna Graziele Marques da Silva, Carlos Alberto-Silva, Maricilia Silva Costa
BACKGROUND: Candida albicans is an opportunistic fungus producing both superficial and systemic infections, especially in immunocompromised individuals. It has been demonstrated that C. albicans ability to form biofilms is a crucial process for colonization and virulence. Furthermore, a correlation between the development of drug resistance and biofilm maturation at Candida biofilms has been shown. Photodynamic Antimicrobial Chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a non-toxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells...
December 5, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/29220545/effects-of-the-bidentate-ligand-on-the-photophysical-properties-cellular-uptake-and-phototoxicity-of-glycoconjugates-based-upon-the-ru-tpy-nn-l-2-scaffold
#5
Lucien N Lameijer, Tobias G Brevé, Vincent H S van Rixel, Sven H C Askes, Maxime A Siegler, Sylvestre Bonnet
Ruthenium polypyridyl complexes have received widespread attention as potential chemotherapeutics in photodynamic therapy (PDT) and in photochemotherapy (PACT). Herein we investigate a series of sixteen ruthenium polypyridyl complexes with general formula [Ru(tpy)(N-N)(L)]+/2+ (tpy = 2,2':6',2''-terpyridine, N-N = bpy (2,2'-bipyridine), phen (1,10-phenanthroline), dpq (pyrazino[2,3-f][1,10]phenanthroline), dppz (dipyrido[3,2-a:2',3'-c]phenazine, dppn (benzo[i]dipyrido[3,2-a:2',3'-c]phenazine), pmip (2-(4-methyl-phen-yl)-1H-imidazo[4,5-f][1,10]phenanthroline), pymi ((E)-N-phenyl-1-(pyridin-2-yl)methanimine), or azpy (2-(phenylazo)pyridine), L = Cl or 2-(2-(2-(methylthio)ethoxy)ethoxy)ethyl-β-d-glucopyranoside) and their potential for either PDT or PACT...
December 8, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29203501/effect-of-a-newly-designed-observation-response-and-discharge-chart-in-the-post-anaesthesia-care-unit-on-patient-outcomes-a-quasi-expermental-study-in-australia
#6
Maryann Street, Nicole M Phillips, Mohammadreza Mohebbi, Bridie Kent
OBJECTIVES: This study aimed to evaluate whether use of a discharge criteria tool for nursing assessment of patients in Post Anaesthesia Care Unit (PACU) would enhance nurses' recognition and response to patients at-risk of deterioration and improve patient outcomes. METHODS: A prospective non-randomised pre-post intervention study was conducted in three hospitals in Australia. Participants were adults undergoing elective surgery before (n=723) and after (n=694) implementation of the Post-Anaesthetic Care Tool (PACT)...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29200939/photochemical-properties-and-structure-activity-relationships-of-ruii-complexes-with-pyridylbenzazole-ligands-as-promising-anticancer-agents
#7
Dmytro Havrylyuk, David K Heidary, Leona Nease, Sean Parkin, Edith C Glazer
Ruthenium complexes capable of light-triggered cytotoxicity are appealing potential prodrugs for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT). Two groups of Ru(II) polypyridyl complexes with 2-(2-pyridyl)-benzazole ligands were synthesized and investigated for their photochemical properties and anticancer activity to compare strained and unstrained systems that are likely to have different biological mechanisms of action. The structure-activity relationship was focused on the benzazole core bioisosterism and replacement of coligands in Ru(II) complexes...
March 27, 2017: European Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29200447/design-and-validation-of-patient-centered-communication-tools-pact-to-measure-students-communication-skills
#8
Gloria R Grice, Nicole M Gattas, Theresa Prosser, Mychal Voorhees, Clark Kebodeaux, Amy Tiemeier, Tricia M Berry, Alexandria Garavaglia Wilson, Janelle Mann, Paul Juang
Objective. To develop a comprehensive instrument specific to student pharmacist-patient communication skills, and to determine face, content, construct, concurrent, and predictive validity and reliability of the instrument. Methods. A multi-step approach was used to create and validate an instrument, including the use of external experts for face and content validity, students for construct validity, comparisons to other rubrics for concurrent validity, comparisons to other coursework for predictive validity, and extensive reliability and inter-rater reliability testing with trained faculty assessors...
October 2017: American Journal of Pharmaceutical Education
https://www.readbyqxmd.com/read/29196483/partners-at-care-transitions-pact-e-xploring-older-peoples-experiences-of-transitioning-from-hospital-to-home-in-the-uk-protocol-for-an-observation-and-interview-study-of-older-people-and-their-families-to-understand-patient-experience-and-involvement-in-care
#9
Natasha Kate Hardicre, Yvonne Birks, Jenni Murray, Laura Sheard, Lesley Hughes, Jane Heyhoe, Alison Cracknell, Rebecca Lawton
INTRODUCTION: Length of hospital inpatient stays have reduced. This benefits patients, who prefer to be at home, and hospitals, which can treat more people when stays are shorter. Patients may, however, leave hospital sicker, with ongoing care needs. The transition period from hospital to home can be risky, particularly for older patients with complex health and social needs. Improving patient experience, especially through greater patient involvement, may improve outcomes for patients and is a key indicator of care quality and safety...
December 1, 2017: BMJ Open
https://www.readbyqxmd.com/read/29177606/the-association-between-child-and-family-characteristics-and-the-mental-health-and-wellbeing-of-caregivers-of-children-with-autism-in-mid-childhood
#10
Erica Salomone, Kathy Leadbitter, Catherine Aldred, Barbara Barrett, Sarah Byford, Tony Charman, Patricia Howlin, Jonathan Green, Ann Le Couteur, Helen McConachie, Jeremy R Parr, Andrew Pickles, Vicky Slonims
We examined predictors of mental health difficulties and wellbeing in caregivers of children with autism in the Pre-school Autism Communication Trial cohort in middle childhood (N = 104). Child's intellectual disability, daily living skills impairment, elevated emotional and behavioural difficulties, high educational level of caregiver and household income below the median significantly predicted caregivers' mental health difficulties, but autism severity, child communication skills and family circumstances did not...
November 25, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29173037/can-women-facilitate-men-s-prostate-cancer-screening-informed-decision-making-the-m-pact-trial
#11
Cheryl L Holt, Daisy Le, Jimmie L Slade, Bettye Muwwakkil, Darlene R Saunders, Ralph Williams, Nancy L Atkinson, Michael Naslund
The M-PACT study compared an all-male with a mixed-sex intervention to increase informed decision-making for prostate cancer screening among African-American men in church settings. We recruited 262 men in 18 churches randomized to the two intervention approaches. Trained and certified lay peer community health advisors in each church led a series of four men's health workshops on informed decision-making for prostate cancer screening. African-American male workshop participants completed baseline, post-workshop, and 12-month follow-up surveys...
November 27, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/29170442/inhibition-of-the-inflammatory-response-to-stress-by-targeting-interaction-between-pkr-and-its-cellular-activator-pact
#12
Stephanie Dabo, Patrick Maillard, Milagros Collados Rodriguez, Marianne Doré Hansen, Sabrina Mazouz, Donna-Joe Bigot, Marion Tible, Geneviève Janvier, Olivier Helynck, Patricia Cassonnet, Yves Jacob, Jacques Bellalou, Anne Gatignol, Rekha C Patel, Jacques Hugon, Hélène Munier-Lehmann, Eliane F Meurs
PKR is a cellular kinase involved in the regulation of the integrative stress response (ISR) and pro-inflammatory pathways. Two N-terminal dsRNA Binding Domains (DRBD) are required for activation of PKR, by interaction with either dsRNA or PACT, another cellular DRBD-containing protein. A role for PKR and PACT in inflammatory processes linked to neurodegenerative diseases has been proposed and raised interest for pharmacological PKR inhibitors. However, the role of PKR in inflammation is subject to controversy...
November 23, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29163327/the-state-of-neurocritical-care-fellowship-training-and-attitudes-toward-accreditation-and-certification-a-survey-of-neurocritical-care-fellowship-program-directors
#13
Rajat Dhar, Venkatakrishna Rajajee, Anna Finley Caulfield, Matthew B Maas, Michael L James, Avinash Bhargava Kumar, Stephen A Figueroa, David McDonagh, Agnieszka Ardelt
Neurocritical care as a recognized and distinct subspecialty of critical care has grown remarkably since its inception in the 1980s. As of 2016, there were 61 fellowship training programs accredited by the United Council for Neurologic Subspecialties (UCNS) in the United States and more than 1,000 UCNS-certified neurointensivists from diverse medical backgrounds. In late 2015, the Program Accreditation, Physician Certification, and Fellowship Training (PACT) Committee of the Neurocritical Care Society (NCS) was convened to promote and support excellence in the training and certification of neurointensivists...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/29154464/patient-centered-medical-home-implementation-and-improved-chronic-disease-quality-a-longitudinal-observational-study
#14
Ann-Marie Rosland, Edwin Wong, Matthew Maciejewski, Donna Zulman, Rebecca Piegari, Stephan Fihn, Karin Nelson
OBJECTIVE: To examine associations between clinics' extent of patient-centered medical home (PCMH) implementation and improvements in chronic illness care quality. DATA SOURCE: Data from 808 Veterans Health Administration (VHA) primary care clinics nationwide implementing the Patient Aligned Care Teams (PACT) PCMH initiative, begun in 2010. DESIGN: Clinic-level longitudinal observational study of clinics that received training and resources to implement PACT...
November 20, 2017: Health Services Research
https://www.readbyqxmd.com/read/29150738/the-autism-family-experience-questionnaire-afeq-an-ecologically-valid-parent-nominated-measure-of-family-experience-quality-of-life-and-prioritised-outcomes-for-early-intervention
#15
Kathy Leadbitter, Catherine Aldred, Helen McConachie, Ann Le Couteur, Dharmi Kapadia, Tony Charman, Wendy Macdonald, Erica Salomone, Richard Emsley, Jonathan Green
There is a lack of measures that reflect the intervention priorities of parents of children with autism spectrum disorder (ASD) and that assess the impact of interventions on family experience and quality of life. The Autism Family Experience Questionnaire (AFEQ) was developed through focus groups and online consultation with parents, and reflected parental priorities. It was then administered to the parents of children enrolled in the Pre-school Autism Communication Trial and its 6-year follow-up study. The AFEQ showed good convergent validity with well-established measures of child adaptive functioning, parental mental health and parental wellbeing...
November 18, 2017: Journal of Autism and Developmental Disorders
https://www.readbyqxmd.com/read/29131179/improved-back-projection-method-for-circular-scanning-based-photoacoustic-tomography-with-improved-tangential-resolution
#16
Jiaying Xiao, Xiaofei Luo, Kuan Peng, Bo Wang
While photoacoustic computed tomography (PACT) is generally built with planar transducers of finite size, most current reconstruction algorithms assume the transducer to be an ideal point, which leads to a spinning blur in the consequently obtained PACT images due to the model mismatch. In this work, we put forward an improved back-projection method that factors in the geometry of the transducers to improve the tangential resolution for the reconstruction of 2D circular-scanning-based photoacoustic tomography...
November 10, 2017: Applied Optics
https://www.readbyqxmd.com/read/29123559/factors-associated-with-success-in-the-oral-part-of-the-european-diploma-in-intensive-care
#17
Petr Waldauf, Francesca Rubulotta, Christian Sitzwohl, Paul Elbers, Armand Girbes, Rajnish Saha, Brian Marsh, Ravindra Kumar, Marco Maggiorini, František Duška
Introduction: The oral part of European Diploma in Intensive Care diploma examinations changed in 2013 into an objective structured clinical examination-type exam. This step was undertaken to provide a fair and reproducible clinical exam. All candidates face identical questions with predefined correct answers simultaneously in seven high throughput exam centres on the same day. We describe the factors that are associated with success in part 2 European Diploma in Intensive Care exam. Methods: We prospectively collected self-reported data from all candidates sitting European Diploma in Intensive Care part 2 in 2015, namely demographics, professional background and attendance to a European Diploma in Intensive Care part 2 or generic objective structured clinical examination preparatory courses...
November 2017: Journal of the Intensive Care Society
https://www.readbyqxmd.com/read/29117951/long-term-benefit-of-enzyme-replacement-therapy-in-pompe-disease-a-5-year-prospective-study
#18
Esther Kuperus, Michelle E Kruijshaar, Stephan C A Wens, Juna M de Vries, Marein M Favejee, Jan C van der Meijden, Dimitris Rizopoulos, Esther Brusse, Pieter A van Doorn, Ans T van der Ploeg, Nadine A M E van der Beek
OBJECTIVE: To determine the effect of enzyme replacement therapy (ERT) after 5 years and to identify predictors for a favorable response because few data are available on the long-term efficacy of ERT in Pompe disease. METHODS: We included 102 adult patients with Pompe disease in a nationwide, prospective cohort study. We assessed muscle strength (manual muscle testing with Medical Research Council [MRC] grading, handheld dynamometry [HHD]), muscle function (6-minute walk test, Quick Motor Function Test), daily life activities (Rasch-Built Pompe-Specific Activity [R-PAct] Scale), and pulmonary function (forced vital capacity [FVC] in upright and supine positions, maximum inspiratory and expiratory pressures) at 3- to 6-month intervals before and after the start of ERT...
November 8, 2017: Neurology
https://www.readbyqxmd.com/read/29090091/cost-effectiveness-of-ceftolozane-tazobactam-plus-metronidazole-versus-piperacillin-tazobactam-as-initial-empiric-therapy-for-the-treatment-of-complicated-intra-abdominal-infections-based-on-pathogen-distributions-drawn-from-national-surveillance-data-in-the
#19
Vimalanand S Prabhu, Joseph S Solomkin, Goran Medic, Jason Foo, Rebekah H Borse, Teresa Kauf, Benjamin Miller, Shuvayu S Sen, Anirban Basu
BACKGROUND: The prevalence of antimicrobial resistance among gram-negative pathogens in complicated intra-abdominal infections (cIAIs) has increased. In the absence of timely information on the infecting pathogens and their susceptibilities, local or regional epidemiology may guide initial empirical therapy and reduce treatment failure, length of stay and mortality. The objective of this study was to assess the cost-effectiveness of ceftolozane/tazobactam + metronidazole compared with piperacillin/tazobactam in the treatment of hospitalized US patients with cIAI at risk of infection with resistant pathogens...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29084250/kshv-inhibits-stress-granule-formation-by-viral-orf57-blocking-pkr-activation
#20
Nishi R Sharma, Vladimir Majerciak, Michael J Kruhlak, Zhi-Ming Zheng
TIA-1 positive stress granules (SG) represent the storage sites of stalled mRNAs and are often associated with the cellular antiviral response. In this report, we provide evidence that Kaposi's sarcoma-associated herpesvirus (KSHV) overcomes the host antiviral response by inhibition of SG formation via a viral lytic protein ORF57. By immunofluorescence analysis, we found that B lymphocytes with KSHV lytic infection are refractory to SG induction. KSHV ORF57, an essential post-transcriptional regulator of viral gene expression and the production of new viral progeny, inhibits SG formation induced experimentally by arsenite and poly I:C, but not by heat stress...
October 2017: PLoS Pathogens
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