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https://www.readbyqxmd.com/read/29451116/population-tailored-care-for-homeless-veterans-and-acute-care-use-cost-and-satisfaction-a-prospective-quasi-experimental-trial
#1
Thomas P O'Toole, Erin E Johnson, Matthew Borgia, Amy Noack, Jean Yoon, Elizabeth Gehlert, Jeanie Lo
INTRODUCTION: Although traditional patient-centered medical homes (PCMHs) are effective for patients with complex needs, it is unclear whether homeless-tailored PCMHs work better for homeless veterans. We examined the impact of enrollment in a Veterans Health Administration (VHA) homeless-tailored PCMH on health services use, cost, and satisfaction compared with enrollment in a traditional, nontailored PCMH. METHODS: We conducted a prospective, multicenter, quasi-experimental, single-blinded study at 2 VHA medical centers to assess health services use, cost, and satisfaction during 12 months among 2 groups of homeless veterans: 1) veterans receiving VHA homeless-tailored primary care (Homeless-Patient Aligned Care Team [H-PACT]) and 2) veterans receiving traditional primary care services (PACT)...
February 15, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29440788/effectiveness-of-erythrosine-mediated-photodynamic-antimicrobial-chemotherapy-on-dental-plaque-aerobic-microorganisms-a-randomized-controlled-trial
#2
Manohar Bhat, Swathi Acharya, Kakarla Veera Venkata Prasad, Raghavendra Kulkarni, Anithraj Bhat, Devikripa Bhat
Background: Dental plaque is one of the predominant causes of major oral diseases. Although mechanical and chemical methods are extensively followed to control the development of plaque, plaque-related diseases still persist. Therefore, this necessitates for alternative measures of plaque control, one such alternative is photodynamic antimicrobial chemotherapy (PACT). Materials and Methods: Split mouth randomized clinical trial (CTRI/2017/03/008239) was conducted on 30 participants who reported to the hospital...
May 2017: Journal of Indian Society of Periodontology
https://www.readbyqxmd.com/read/29438295/patient-centered-communication
#3
Cynthia A Naughton
As the population ages, morbidity and mortality associated with chronic disease will increase. Some patient-centered improvements have been made in health care services, but optimal health has not been fully realized. Only when pharmacists have a holistic understanding of an individual patient, including their experience of illness and medication, can they effectively assess appropriateness, safety, efficacy, and adherence to medications and develop realistic treatment plans. When patients are involved in their care, they are better able to manage complex chronic conditions by understanding and adhering to their plan of care...
February 13, 2018: Pharmacy (Basel, Switzerland)
https://www.readbyqxmd.com/read/29414272/trial-of-prazosin-for-post-traumatic-stress-disorder-in-military-veterans
#4
RANDOMIZED CONTROLLED TRIAL
Murray A Raskind, Elaine R Peskind, Bruce Chow, Crystal Harris, Anne Davis-Karim, Hollie A Holmes, Kimberly L Hart, Miles McFall, Thomas A Mellman, Christopher Reist, Jennifer Romesser, Robert Rosenheck, Mei-Chiung Shih, Murray B Stein, Robert Swift, Theresa Gleason, Ying Lu, Grant D Huang
BACKGROUND: In randomized trials, prazosin, an α1 -adrenoreceptor antagonist, has been effective in alleviating nightmares associated with post-traumatic stress disorder (PTSD) in military veterans. METHODS: We recruited veterans from 13 Department of Veterans Affairs medical centers who had chronic PTSD and reported frequent nightmares. Participants were randomly assigned to receive prazosin or placebo for 26 weeks; the drug or placebo was administered in escalating divided doses over the course of 5 weeks to a daily maximum of 20 mg in men and 12 mg in women...
February 8, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29393712/role-of-a-standardized-prism-under-cover-test-in-the-assessment-of-dissociated-vertical-deviation
#5
Lindsay D Klaehn, Sarah R Hatt, David A Leske, Jonathan M Holmes
BACKGROUND: Dissociated vertical deviation (DVD) is commonly measured using a prism and alternate cover test (PACT), but some providers use a prism under cover test (PUCT). The aim of this study was to compare a standardized PUCT measurement with a PACT measurement, for assessing the magnitude of DVD. METHODS: Thirty-six patients with a clinical diagnosis of DVD underwent measurement of the angle of deviation with the PACT, fixing with the habitually fixing eye, and with PUCT, fixing both right and left eyes...
February 2, 2018: Strabismus
https://www.readbyqxmd.com/read/29388531/consumption-of-processed-food-dietary-patterns-in-four-african-populations
#6
Michelle D Holmes, Shona Dalal, Vikash Sewram, Megan B Diamond, Sally N Adebamowo, Ikeoluwapo O Ajayi, Clement Adebamowo, Faraja S Chiwanga, Marina Njelekela, Carien Laurence, Jimmy Volmink, Francis Bajunirwe, Joan Nankya-Mutyoba, David Guwatudde, Todd G Reid, Walter C Willett, Hans-Olov Adami, Teresa T Fung
OBJECTIVE: To identify predominant dietary patterns in four African populations and examine their association with obesity. DESIGN: Cross-sectional study. Setting/Subjects We used data from the Africa/Harvard School of Public Health Partnership for Cohort Research and Training (PaCT) pilot study established to investigate the feasibility of a multi-country longitudinal study of non-communicable chronic disease in sub-Saharan Africa. We applied principal component analysis to dietary intake data collected from an FFQ developed for PaCT to ascertain dietary patterns in Tanzania, South Africa, and peri-urban and rural Uganda...
February 1, 2018: Public Health Nutrition
https://www.readbyqxmd.com/read/29385577/interprofessional-case-conference-impact-on-learner-outcomes
#7
Jeffrey Sordahl, India C King, Kyle Davis, Rick Tivis, Scott C Smith, Amber Fisher, Janet Willis, Timothy Gordon, William G Weppner
Transition to interprofessional team-based care is a quickly progressing healthcare model and requires changes in medical training approaches. The Department of Veteran Affairs (VA) has taken a lead role in creating such training experiences, one of which is the establishment of multiple Centers of Excellence in Primary Care Education (CoEPCE). These sites are tasked with developing teaching innovations to better facilitate interprofessional team-based care. The patient-aligned care team interprofessional care update (PACT-ICU) is an interprofessional workplace learning activity with the goals of simultaneously addressing educational and patient care needs...
January 27, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29379275/real-life-experience-of-quality-of-life-treatment-satisfaction-and-adherence-in-patients-receiving-oral-anticoagulants-for-atrial-fibrillation
#8
Michaël Benzimra, Béatrix Bonnamour, Martin Duracinsky, Christophe Lalanne, Jean-Pierre Aubert, Olivier Chassany, Isabelle Aubin-Auger, Isabelle Mahé
Introduction: Direct oral anticoagulants (DOACs) have shown noninferiority to vitamin K antagonists (VKA) in stroke prevention in patients with atrial fibrillation. DOAC treatment may be less demanding than VKA, improving quality of life. To date, there have been no studies of the real-life experience of outpatients receiving anticoagulation therapy for atrial fibrillation in France. Methods: An observational descriptive real-life epidemiological study used three validated questionnaires (EQ-5D, PACT-Q2, and MMAS-8 French Translation) to assess quality of life, treatment satisfaction, and adherence, respectively, in 200 patients managed on an outpatient basis for atrial fibrillation who were receiving anticoagulation therapy by VKA or DOAC for at least 3 months...
2018: Patient Preference and Adherence
https://www.readbyqxmd.com/read/29348664/stress-induced-trbp-phosphorylation-enhances-its-interaction-with-pkr-to-regulate-cellular-survival
#9
Evelyn Chukwurah, Rekha C Patel
Transactivation response element RNA-binding protein (TRBP or TARBP2) initially identified to play an important role in human immunodeficiency virus (HIV) replication also has emerged as a regulator of microRNA biogenesis. In addition, TRBP functions in signaling pathways by negatively regulating the interferon-induced double-stranded RNA (dsRNA)-activated protein kinase (PKR) during viral infections and cell stress. During cellular stress, PKR is activated and phosphorylates the α subunit of the eukaryotic translation factor eIF2, leading to the cessation of general protein synthesis...
January 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29344392/evaluating-the-parent-adolescent-communication-toolkit-usability-and-preliminary-content-effectiveness-of-an-online-intervention
#10
Elaine Toombs, Anita Unruh, Patrick McGrath
Aim: This study aimed to assess the Parent-Adolescent Communication Toolkit, an online intervention designed to help improve parent communication with their adolescents. Participant preferences for two module delivery systems (sequential and unrestricted module access) were identified. Design: Usability assessment of the PACT intervention was completed using pre-test and posttest comparisons. Usability data, including participant completion and satisfaction ratings were examined...
January 2018: Nursing Open
https://www.readbyqxmd.com/read/29332258/photodynamic-antimicrobial-chemotherapy-pact-using-toluidine-blue-inhibits-both-growth-and-biofilm-formation-by-candida-krusei
#11
Bruna Graziele Marques da Silva, Moisés Lopes Carvalho, Isabela Bueno Rosseti, Stella Zamuner, Maricilia Silva Costa
Among non-albicans Candida species, the opportunistic pathogen Candida krusei emerges because of the high mortality related to infections produced by this yeast. The Candida krusei is an opportunistic pathogen presenting an intrinsic resistance to fluconazol. In spite of the reduced number of infections produced by C. krusei, its occurrence is increasing in some groups of patients submitted to the use of fluconazol for prophylaxis. Photodynamic antimicrobial chemotherapy (PACT) is a potential antimicrobial therapy that combines visible light and a nontoxic dye, known as a photosensitizer, producing reactive oxygen species (ROS) that can kill the treated cells...
January 13, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29330243/task-delegation-and-burnout-trade-offs-among-primary-care-providers-and-nurses-in-veterans-affairs-patient-aligned-care-teams-va-pacts
#12
Samuel T Edwards, Christian D Helfrich, David Grembowski, Elizabeth Hulen, Walter L Clinton, Gordon B Wood, Linda Kim, Danielle E Rose, Greg Stewart
PURPOSE: Appropriate delegation of clinical tasks from primary care providers (PCPs) to other team members may reduce employee burnout in primary care. However, (1) the extent to which delegation occurs within multidisciplinary teams, (2) factors associated with greater delegation, and (3) whether delegation is associated with burnout are all unknown. METHODS: We performed a national cross-sectional survey of Veterans Affairs (VA) PCP-nurse dyads in Department of VA primary care clinics, 4 years into the VA's patient-centered medical home initiative...
January 2018: Journal of the American Board of Family Medicine: JABFM
https://www.readbyqxmd.com/read/29326494/experience-of-an-academic-institute-in-importing-a-novel-preclinical-drug-into-india
#13
M Praveen Kumar, Bikash Medhi
The article throws light on the process of importing a novel preclinical drug into India based on the real-life experience from one of our studies. A novel drug "X" acting through a new mechanism of action was hypothesized by us to function as a neuroprotectant. It was decided to import this novel drug from a university located in Brazil. An official collaboration pact was exchanged between both the sides. In accordance with the Indian Drug and Cosmetics Act 1940, unauthorized import of drug into India is not permitted...
July 2017: Indian Journal of Pharmacology
https://www.readbyqxmd.com/read/29326153/treatment-effect-of-drug-coated-balloons-is-durable-to-3-years-in-the-femoropopliteal-arteries-long-term-results-of-the-in-pact-sfa-randomized-trial
#14
Peter A Schneider, John R Laird, Gunnar Tepe, Marianne Brodmann, Thomas Zeller, Dierk Scheinert, Christopher Metzger, Antonio Micari, Ravish Sachar, Michael R Jaff, Hong Wang, Melissa S Hasenbank, Prakash Krishnan
BACKGROUND: Randomized controlled trials have reported favorable 1-year outcomes with drug-coated balloons (DCBs) for the treatment of symptomatic peripheral arterial disease when compared with standard percutaneous transluminal angioplasty (PTA). Evidence remains limited on the durability of the treatment effect with DCBs in the longer term. METHODS AND RESULTS: IN.PACT SFA is a single-blind, randomized trial (Randomized Trial of IN.PACT Admiral Paclitaxel-Coated Percutaneous Transluminal Angioplasty [PTA] Balloon Catheter vs Standard PTA for the Treatment of Atherosclerotic Lesions in the Superficial Femoral Artery [SFA] and/or Proximal Popliteal Artery [PPA]) that enrolled 331 patients with symptomatic (Rutherford 2-4) femoropopliteal lesions up to 18 cm in length...
January 2018: Circulation. Cardiovascular Interventions
https://www.readbyqxmd.com/read/29324840/malaria-increased-the-risk-of-stunting-and-wasting-among-young-children-in-ethiopia-results-of-a-cohort-study
#15
Taye Gari, Eskindir Loha, Wakgari Deressa, Tarekegn Solomon, Bernt Lindtjørn
INTRODUCTION: Given the high prevalence of malnutrition in a malaria-endemic setting, improving nutritional status could serve as a tool to prevent malaria. However, the relationship between the two conditions remains unclear. Therefore, this study assessed the association between under-nutrition and malaria among a cohort of children aged 6 to 59 months old. METHODS: Two cohorts of children were followed for 89 weeks in a rural Rift Valley area of Ethiopia. In the first approach (malaria-malnutrition), a cohort of 2,330 non-stunted and 4,204 non-wasted children were included to assess under-nutrition (outcome) based on their previous malaria status (exposure)...
2018: PloS One
https://www.readbyqxmd.com/read/29313498/the-delegation-of-tasks-in-the-era-of-e-health-to-support-community-interventions-in-maternal-and-child-health-lessons-learned-from-the-pact-denbaya-project
#16
C-O Bagayoko, M Niang, A Anne, D Traoré, H Sangho, A-K Traoré, A Geissbuhler
The PACT-Denbaya project (Program for community access to telemedicine for families) aimed to help improve the health of mothers and child in rural communities through the delegation of obstetric-gynecologic and pediatric tasks, supported by teleconsultations. This operational research took place in 6 community health centers in the Dioïla health district in Mali. Our method was based of the delegation of tasks, supported by teleconsultations. Experts in pediatrics and obstetrics/gynecology provided a week-long training program to general practitioners and midwives, in the management of the most common problems in the field and in the use of the "Bogou" teleconsultation and "Dudal" tele-education platforms to ensure exchanges and follow-up...
November 1, 2017: Médecine et Santé Tropicales
https://www.readbyqxmd.com/read/29280778/perceptions-of-integration-of-the-clinical-pharmacist-into-the-pcmh-model-by-the-pcmh-team
#17
M Shawn McFarland, Kristen Lamb, Jonathan Hughes, Ashley Thomas, Justin Gatwood, Jacob Hathaway
INTRODUCTION: The patient-centered medical home (PCMH) model is a multidisciplinary, team-based approach to healthcare that focuses on actively involving the patient in clinical decision making. The Veterans Health Administration (VA), while desiring to be a national leader in the delivery of primary care services, used the principles of the PCMH model to design the patient-aligned care team (PACT). The purpose of this study, was to explore the perception of the PACT members after integration of a clinical pharmacist to the PACT...
December 22, 2017: Journal for Healthcare Quality: Official Publication of the National Association for Healthcare Quality
https://www.readbyqxmd.com/read/29235043/effects-of-physical-exercise-on-markers-of-inflammation-in-breast-cancer-patients-during-adjuvant-chemotherapy
#18
Jonna K van Vulpen, Martina E Schmidt, Miranda J Velthuis, Joachim Wiskemann, Andreas Schneeweiss, Roel C H Vermeulen, Nina Habermann, Cornelia M Ulrich, Petra H M Peeters, Elsken van der Wall, Anne M May, Karen Steindorf
PURPOSE: Exercise has been shown to reduce fatigue during cancer treatment. Hypothesized mechanisms include inflammatory pathways. Therefore, we investigated effects of exercise on markers of inflammation in breast cancer patients during adjuvant chemotherapy. METHODS: We pooled data from two randomized controlled exercise intervention trials with breast cancer patients during adjuvant chemotherapy (n = 130), which had previously shown beneficial effects of exercise on fatigue...
December 12, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29231267/contribution-of-the-two-dsrbm-motifs-to-the-double-stranded-rna-binding-and-protein-interactions-of-pact
#19
Evelyn Chukwurah, Victoria Willingham, Madhurima Singh, David Castillo-Azofeifa, Rekha C Patel
PACT is a stress-modulated activator of protein kinase PKR (protein kinase, RNA activated), which is involved in antiviral innate immune responses and stress-induced apoptosis. Stress-induced phosphorylation of PACT is essential for PACT's increased association with PKR leading to PKR activation, phosphorylation of translation initiation factor eIF2α, inhibition of protein synthesis, and apoptosis. PACT-induced PKR activation is negatively regulated by TRBP (Transactivation response element RNA-binding protein), which dissociates from PACT after PACT phosphorylation in response to stress signals...
December 12, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29227279/drug-eluting-balloon-design-technology-and-clinical-aspects
#20
Meenasree Bukka, Poorna Jyothi Rednam, Mukty Sinha
Drug eluting balloon is a non-stent technology in which an effective homogenous delivery of anti-proliferative drug processed to the vessel wall through inflated balloon. This is done to restore luminal vascularity in order to treat atherosclerosis, in-stent restenosis and reduce risk of late thrombosis without implanting a permanent foreign object. The balloon technology relies on the concept of targeted delivery of drug which helps in rapid healing of vessel wall and prevents the proliferation of smooth muscle cell...
December 11, 2017: Biomedical Materials
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