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https://www.readbyqxmd.com/read/28406644/influence-of-the-steric-bulk-and-solvent-on-the-photoreactivity-of-ruthenium-polypyridyl-complexes-coordinated-to-l-proline
#1
Jordi-Amat Cuello-Garibo, Elena Pérez-Gallent, Lennard van der Boon, Maxime A Siegler, Sylvestre Bonnet
Ruthenium polypyridyl complexes are good candidates for photoactivated chemotherapy (PACT) provided that they are stable in the dark but efficiently photosubstitute one of their ligands. Here the use of the natural amino acid l-proline as a protecting ligand for ruthenium-based PACT compounds is investigated in the series of complexes Λ-[Ru(bpy)2(l-prol)]PF6 ([1a]PF6; bpy = 2,2'-bipyridine and l-prol = l-proline), Λ-[Ru(bpy)(dmbpy)(l-prol)]PF6 ([2a]PF6 and [2b]PF6; dmbpy = 6,6'-dimethyl-2,2'-bipyridine), and Λ-[Ru(dmbpy)2(l-prol)]PF6 ([3a]PF6)...
April 13, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28385413/what-does-the-in-pact-sfa-long-study-tell-us
#2
EDITORIAL
Osamu Iida, Mitsuyoshi Takahara, Toshiaki Mano
No abstract text is available yet for this article.
April 10, 2017: JACC. Cardiovascular Interventions
https://www.readbyqxmd.com/read/28333700/intimate-partner-violence-a-rare-case-of-reciprocal-homicide
#3
Aurélie Cauchois, François Paraire, Geoffroy Lorin de la Grandmaison
We present the case of a reciprocal homicide by stabbing that occurred within an unmarried couple without known history of spousal violence. Each partner killed the other one at the same time and at the same place using kitchen knives. They were both found dead at home lying on the floor after the neighbors heard an argument and screams coming from the couple's apartment, so they called the police and the fire department. The door was locked from the inside, and the fire department was forced to break the door...
March 23, 2017: American Journal of Forensic Medicine and Pathology
https://www.readbyqxmd.com/read/28314524/development-of-the-japanese-version-of-the-psychosocial-assessment-of-candidates-for-transplantation-in-allogeneic-hematopoietic-stem-cell-transplantation
#4
Saki Harashima, Ryo Yoneda, Takeshi Horie, Mami Kayano, Yosei Fujioka, Fumihiko Nakamura, Mineo Kurokawa, Kazuhiro Yoshiuchi
BACKGROUND: The Psychosocial Assessment of Candidates for Transplantation (PACT) is a validated instrument for evaluating psychosocial risk factors in transplant candidates. OBJECTIVES: This study examined reliability and validity of the Japanese version of the PACT (J-PACT). METHODS: PACT is a clinician-rated scale consisting of an initial rating, 8 subscales, and a final rating. J-PACT was developed through a translation and back-translation procedure...
January 19, 2017: Psychosomatics
https://www.readbyqxmd.com/read/28296722/design-methodology-and-baseline-data-of-the-personalized-addition-lenses-clinical-trial-pact
#5
RANDOMIZED CONTROLLED TRIAL
Xinping Yu, Binjun Zhang, Jinhua Bao, Junxiao Zhang, Ge Wu, Jinling Xu, Jingwei Zheng, Björn Drobe, Hao Chen
BACKGROUND: The aim of this study was to describe the design, methods, and baseline characteristics of children enrolled in the Personalized Addition lenses Clinical Trial (PACT). PACT aims to test the myopia control efficacy of progressive addition lenses (PALs) with personalized addition values compared with standard (+2.00 D) addition PALs and single vision lenses (SVLs). METHODS: PACT is a randomized, controlled, double-masked clinical trial. Two hundred eleven myopic Chinese children (7-12 years) were enrolled and randomized into 1 of the 3 following groups: personalized addition PALs; +2...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28284586/do-bedsider-family-planning-mobile-text-message-and-e-mail-reminders-increase-kept-appointments-and-contraceptive-coverage
#6
Heike Thiel de Bocanegra, Mary Bradsberry, Carrie Lewis, Fran Maguire
OBJECTIVE: To determine whether Bedsider text message and e-mail reminders increase family planning contraceptive continuation and appointment rates. MATERIAL AND METHODS: We trained staff at three high-volume Family Planning, Access, Care, and Treatment (Family PACT) clinics to enroll women through a special portal to receive text message or e-mail reminders for contraceptive refills and clinic appointments. Women were matched by contraceptive method, time frame of index visit, age group, and language preference to Family PACT clients at comparison sites that did not use the Bedsider program...
March 9, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/28264824/cost-effectiveness-analysis-of-an-18-week-exercise-programme-for-patients-with-breast-and-colon-cancer-undergoing-adjuvant-chemotherapy-the-randomised-pact-study
#7
Anne M May, Marcel J C Bosch, Miranda J Velthuis, Elsken van der Wall, Charlotte N Steins Bisschop, Maartje Los, Frans Erdkamp, Haiko J Bloemendal, Marnix A J de Roos, Marlies Verhaar, Daan Ten Bokkel Huinink, Petra H M Peeters, G Ardine de Wit
OBJECTIVE: Meta-analyses show that exercise interventions during cancer treatment reduce cancer-related fatigue. However, little is known about the cost-effectiveness of such interventions. Here we aim to assess the cost-effectiveness of the 18-week physical activity during cancer treatment (PACT) intervention for patients with breast and colon cancer. The PACT trial showed beneficial effects for fatigue and physical fitness. DESIGN: Cost-effectiveness analyses with a 9-month time horizon (18 weeks of intervention and 18 weeks of follow-up) within the randomised controlled multicentre PACT study...
March 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28251266/rapid-killing-of-bacteria-by-a-new-type-of-photosensitizer
#8
Yaxin Zhang, Ke Zheng, Zhuo Chen, Jincan Chen, Ping Hu, Linrong Cai, Zafar Iqbal, Mingdong Huang
Photodynamic antimicrobial chemotherapy (PACT) uses non-traditional mechanisms (free radicals) and is a highly advocated method with promise of inactivating drug-resistance bacteria for local infections. However, there is no related drug used in clinical practice yet. Therefore, new photosensitizers for PACT are under active development. Here, we report the synthesis of a series of photosensitizers with variable positive charges (ZnPc(TAP)4(n+), n = 0, 4, 8, 12) and their inactivation against Gram-positive (Staphylococcus aureus) and Gram-negative (Escherichia coli) bacteria...
March 1, 2017: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/28248804/standardizing-the-initial-resuscitation-of-the-trauma-patient-with-the-primary-assessment-completion-tool-pact-using-video-review
#9
Lee Ann Wurster, Rajan K Thakkar, Kathy J Haley, Krista K Wheeler, Jeremy Larson, Michael Stoner, Yaffa Gewirtz, Todd Holman, Don Buckingham, Jonathan I Groner
BACKGROUND: Major trauma resuscitations at pediatric trauma centers have an elevated risk for error due to their high acuity and relatively low frequency. The Advanced Trauma Life Support® (ATLS®) treatment paradigm was established to improve the management of trauma patients during the initial resuscitation phase and has been shown to improve outcomes through a standardized approach. The goal of this quality improvement project was to decrease assessment physician variability and improve the compliance with the ATLS® primary assessment for major resuscitations...
February 28, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28214405/our-faustian-pact-with-the-digital-world
#10
Catriona M McNeil, Paul R Harnett
No abstract text is available yet for this article.
February 2017: Lancet Oncology
https://www.readbyqxmd.com/read/28211501/high-resolution-3d-imaging-of-whole-organ-after-clearing-taking-a-new-look-at-the-zebrafish-testis
#11
Maxence Frétaud, Laurie Rivière, Élodie De Job, Stéphanie Gay, Jean-Jacques Lareyre, Jean-Stéphane Joly, Pierre Affaticati, Violette Thermes
Zebrafish testis has become a powerful model for reproductive biology of teleostean fishes and other vertebrates and encompasses multiple applications in applied and basic research. Many studies have focused on 2D images, which is time consuming and implies extrapolation of results. Three-dimensional imaging of whole organs recently became an important challenge to better understand their architecture and allow cell enumeration. Several protocols have thus been developed to enhance sample transparency, a limiting step for imaging large biological samples...
February 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28207883/application-of-an-optimized-flow-cytometry-based-quantification-of-platelet-activation-pact-monitoring-platelet-activation-in-platelet-concentrates
#12
Cécile H Kicken, Mark Roest, Yvonne M C Henskens, Bas de Laat, Dana Huskens
BACKGROUND: Previous studies have shown that flow cytometry is a reliable test to quantify platelet function in stored platelet concentrates (PC). It is thought that flow cytometry is laborious and hence expensive. We have optimized the flow cytometry-based quantification of agonist induced platelet activation (PACT) to a labor, time and more cost-efficient test. Currently the quality of PCs is only monitored by visual inspection, because available assays are unreliable or too laborious for use in a clinical transfusion laboratory...
2017: PloS One
https://www.readbyqxmd.com/read/28178523/the-mitochondrial-rhomboid-protease-parl-is-regulated-by-pdk2-to-integrate-mitochondrial-quality-control-and-metabolism
#13
Guang Shi, G Angus McQuibban
Mitochondrial quality control (MQC) systems are essential for mitochondrial health and normal cellular function. Dysfunction of MQC is emerging as a central mechanism for the pathogenesis of various diseases, including Parkinson's disease. The mammalian mitochondrial rhomboid protease, PARL, has been proposed as a regulator of PINK1/PARKIN-mediated mitophagy, which is an essential component of MQC. PARL undergoes an N-terminal autocatalytic cleavage (β cleavage), which is required for efficient mitophagy...
February 7, 2017: Cell Reports
https://www.readbyqxmd.com/read/28167698/adar1-and-pact-contribute-to-efficient-translation-of-transcripts-containing-hiv-1-trans-activating-response-tar-element
#14
Evelyn Chukwurah, Indhira Handy, Rekha C Patel
Human immunodeficiency virus type 1 (HIV-1) has evolved various measures to counter the host cell's innate antiviral response during the course of infection. Interferon (IFN)-stimulated gene products are produced following HIV-1 infection to limit viral replication, but viral proteins and RNAs counteract their effect. One such mechanism is specifically directed against the IFN-induced Protein Kinase PKR, which is centrally important to the cellular antiviral response. In the presence of viral RNAs, PKR is activated and phosphorylates the translation initiation factor eIF2α...
March 23, 2017: Biochemical Journal
https://www.readbyqxmd.com/read/28139694/elevated-temperature-induced-acceleration-of-pact-clearing-process-of-mouse-brain-tissue
#15
Tingting Yu, Yisong Qi, Jingtan Zhu, Jianyi Xu, Hui Gong, Qingming Luo, Dan Zhu
Tissue optical clearing technique shows a great potential for neural imaging with high resolution, especially for connectomics in brain. The passive clarity technique (PACT) is a relative simple clearing method based on incubation, which has a great advantage on tissue transparency, fluorescence preservation and immunostaining compatibility for imaging tissue blocks. However, this method suffers from long processing time. Previous studies indicated that increasing temperature can speed up the clearing. In this work, we aim to systematacially and quantitatively study this influence based on PACT with graded increase of temperatures...
January 31, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28129958/cell-based-therapeutics-making-a-faustian-pact-with-biology
#16
REVIEW
Daniel J Woodsworth, Robert A Holt
The diversity and specialization found in biological molecules, pathways, and cells is staggering, and should be exploited for therapeutic use. Through evolution these biological systems have attained a level of functionality that would be impossible to recapitulate with de novo assembly. To adapt these systems for therapeutic applications it will be often necessary to re-engineer molecules and pathways to yield novel sensory, control, and effector modules for insertion into existing, specialized cellular chassis...
January 24, 2017: Trends in Molecular Medicine
https://www.readbyqxmd.com/read/28128927/ru-ii-complex-based-dna-photocleaver-having-intense-absorption-in-the-phototherapeutic-window
#17
Yangyang Zhang, Qianxiong Zhou, Na Tian, Chao Li, Xuesong Wang
Ru(II)-complex-based DNA photocleavers have been extensively studied for their potential application in photodynamic therapy (PDT) and photodynamic antimicrobial chemotherapy (PACT). However, their MLCT absorption maxima are generally shorter than 600 nm, limiting PDT/PACT application severely. In this work, by incorporating a 5-chloro-8-oxyquinolate-based noninnocent ligand into a merocyanine scaffold Cl-7-IVQ, we obtained a new Ru complex of this ligand, [Ru(bpy)2(Cl-7-IVQ)](2+), which has intense absorption in the window 600-700 nm and enables an efficient (•)OH-mediated DNA photocleavage...
February 20, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28121497/effect-of-photodynamic-antimicrobial-chemotherapy-on-mono-and-multi-species-cariogenic-biofilms-a-literature-review
#18
Maria Tayara Marques de Freitas, Talyta Teixeira Soares, Maria Gerusa Brito Aragão, Ramille Araújo Lima, Simone Duarte, Iriana Carla Junqueira Zanin
OBJECTIVE: The aim of this literature review is to study the effect of photodynamic antimicrobial chemotherapy (PACT) on mono and multi-species cariogenic biofilms. METHODS: To this purpose, the database, PubMed, was searched using the descriptors, photodynamic therapy, antimicrobial photodynamic chemotherapy, and photoinactivation, associated with the mandatory presence of the word biofilm. A total of 98 references published from 2003 to 2016 were selected. Moreover, literature reviews (15), investigations that did not have biofilms related to dental caries (65), and those that did not have Streptococcus mutans count as an outcome (7) were excluded, yielding a final amount of 11 publications...
January 24, 2017: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/28112705/antibiotics-alone-for-uncomplicated-acute-appendicitis-in-high-operative-risk-adult-patients-analytical-review-of-rcts-and-proposal-of-evidence-based-treatment-decision
#19
Hariscine Keng Abongwa, G Cervellin, A Tarasconi, G Perrone, G Baiocchi, N Portolani, F Catena
BACKGROUND: Clinical trials have so far shown controversial results as regards the standard of care for treating uncomplicated acute appendicitis (uC-AA). High operational risk adult patients (HORAP) could represent selected patients where primary antibiotic conservative therapy (pACT or A) could be indicated. METHODS: We carried a comprehensive search of the PubMed searching engine in the English language scientific literature from 1995 to 2015, using medical subject headings "antibiotics", "uncomplicated appendicitis", "appendicectomy", "conservative treatment", "surgery" and "randomized clinical trial"...
January 16, 2017: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/28106370/redox-active-cation-intercalation-deintercalation-in-two-dimensional-layered-mno2-nanostructures-for-high-rate-electrochemical-energy-storage
#20
Pan Xiong, Renzhi Ma, Nobuyuki Sakai, Xueyin Bai, Shen Li, Takayoshi Sasaki
Two-dimensional (2D) layered materials with a high intercalation pseudocapacitance have long been investigated for Li(+)-ion-based electrochemical energy storage. By contrast, the exploration of guest ions other than Li(+) has been limited, although promising. The present study investigates intercalation/deintercalation behaviors of various metal ions in 2D layered MnO2 with various interlayer distances, K-birnessite nanobelt (K-MnO2), its protonated form (H-MnO2), and a freeze-dried sample of exfoliated nanosheets...
February 22, 2017: ACS Applied Materials & Interfaces
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