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Nutrition epigenetics

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https://www.readbyqxmd.com/read/29784032/metabolic-recoding-of-epigenetics-in-cancer
#1
REVIEW
Yi-Ping Wang, Qun-Ying Lei
Dysregulation of metabolism allows tumor cells to generate needed building blocks as well as to modulate epigenetic marks to support cancer initiation and progression. Cancer-induced metabolic changes alter the epigenetic landscape, especially modifications on histones and DNA, thereby promoting malignant transformation, adaptation to inadequate nutrition, and metastasis. Recent advances in cancer metabolism shed light on how aberrations in metabolites and metabolic enzymes modify epigenetic programs. The metabolism-induced recoding of epigenetics in cancer depends strongly on nutrient availability for tumor cells...
May 21, 2018: Cancer communications
https://www.readbyqxmd.com/read/29777232/maternal-overnutrition-programs-epigenetic-changes-in-the-regulatory-regions-of-hypothalamic-pomc-in-the-offspring-of-rats
#2
Thanuja Gali Ramamoorthy, Tiffany-Jayne Allen, Alison Davies, Erika Harno, Charlotte Sefton, Christopher Murgatroyd, Anne White
BACKGROUND AND OBJECTIVE: Maternal overnutrition has been implicated in affecting the offspring by programming metabolic disorders such as obesity and diabetes, by mechanisms that are not clearly understood. This study aimed to determine the long-term impact of maternal high-fat (HF) diet feeding on epigenetic changes in the offspring's hypothalamic Pomc gene, coding a key factor in the control of energy balance. Further, it aimed to study the additional effects of postnatal overnutrition on epigenetic programming by maternal nutrition...
May 17, 2018: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/29769529/methionine-metabolism-influences-genomic-architecture-and-gene-expression-through-h3k4me3-peak-width
#3
Ziwei Dai, Samantha J Mentch, Xia Gao, Sailendra N Nichenametla, Jason W Locasale
Nutrition and metabolism are known to influence chromatin biology and epigenetics through post-translational modifications, yet how this interaction influences genomic architecture and connects to gene expression is unknown. Here we consider, as a model, the metabolically-driven dynamics of H3K4me3, a histone methylation mark that is known to encode information about active transcription, cell identity, and tumor suppression. We analyze the genome-wide changes in H3K4me3 and gene expression in response to alterations in methionine availability in both normal mouse physiology and human cancer cells...
May 16, 2018: Nature Communications
https://www.readbyqxmd.com/read/29750884/nutritional-intervention-as-an-essential-part-of-multiple-sclerosis-treatment
#4
A Penesová, Z Dean, B Kollár, A Havranová, R Imrich, M Vlček, Ž Rádiková
Multiple sclerosis (MS) is a chronic inflammatory and demyelinating disease of the central nervous system. In addition to the genetic, epigenetic and immunological components, various other factors e.g. unhealthy dietary habits play a role in the MS pathogenesis. Dietary intervention is a highly appealing approach, as it presents a simple and relatively low risk method to potentially improve outcomes in patients with brain disorders in order to achieve remission and improvement of clinical status, well-being and life expectancy of patients with MS...
May 10, 2018: Physiological Research
https://www.readbyqxmd.com/read/29748034/ampk-induced-memory-improvements-in-the-diabetic-population-a-case-study
#5
Alicia Halikas, Kelly J Gibas
Diabetics in mid-life carry a 1.5 times higher risk of developing Alzheimer's disease than those diagnosed with diabetes (T2D) later in life [1]. Recent research points to accelerated cognitive decline within a range of 20%-50% for middle-aged diabetics as compared to non-diabetic populations [2,3]. Metabolic syndrome (MetS), a type 2 diabetes (T2D) precursor, is also linked to MCI and AD pathologies via hypo-metabolic brain circuitry that inhibits glucose metabolism and attenuates cognitive function [4]. Dysregulation of intracellular and extracellular signaling as mediated by the mTOR and AMPK pathways is the result...
April 27, 2018: Diabetes & Metabolic Syndrome
https://www.readbyqxmd.com/read/29732466/novel-insights-into-the-regulation-of-mirna-transcriptional-control-implications-for-t2d-and-related-complications
#6
Lucia La Sala, Stefano Micheloni, Valeria De Nigris, Francesco Prattichizzo, Antonio Ceriello
In recent years, epigenetics has emerged as an important form of biological regulation involving chromatin control of gene expression. The mechanisms of this fine-tuned regulation are susceptible to changes forced by environmental stimuli and nutritional factors and may be potentially reversible. Dysregulation of epigenetic processes has important consequences for the pathogenesis of complex and multifactorial diseases such as type 2 diabetes (T2D) and vascular complications. Along with DNA methylation (DNA-me), histone modifications and RNA-based mechanisms as the major epigenetic controllers, small non-coding RNAs known as microRNAs (miRNAs) have their own important implications for the pathogenesis of diabetes...
May 7, 2018: Acta Diabetologica
https://www.readbyqxmd.com/read/29732170/nutrition-meets-heredity-a-case-of-rna-mediated-transmission-of-acquired-characters
#7
Minoo Rassoulzadegan, François Cuzin
RNA-based inheritance provides a reasonable hypothesis to explain multigenerational maintenance of the disease in the progeny of either a male or female parent suffering from the metabolic syndrome (obesity and type 2 diabetes) induced by abnormal diet. Although, it is still difficult to formulate a complete rational mechanism, study of inheritance is a most direct way to learn about the epigenetic control of gene expression and we wished to summarised our current approach along this line.
April 2018: Environmental Epigenetics
https://www.readbyqxmd.com/read/29714153/thiamine-and-alcohol-for-brain-pathology-super-imposing-or-different-causative-factors-for-brain-damage
#8
Rita Moretti, Paola Caruso, Matteo Dal Ben, Silvia Gazzin, Claudio Tiribelli
Drinking more than the recommended limits is a worldwide emerging problem, difficult to circumscribe, and alcohol related brain damages are an under-recognized health problem. Alcohol-cognitive disruption can be considered as transient and recoverable if the alcohol consumption is limited and occasional; if not, it can progress to the so-called alcohol-related dementia (ARD), or to the Wernicke encephalopathy, or it can even induce the Korsakoff syndrome, an irreversible and long-lasting medical condition. ARD still remains poorly diagnosed and addressed, even if it had recently raised increased research interest...
April 2, 2018: Current Drug Abuse Reviews
https://www.readbyqxmd.com/read/29709567/-culture-conditions-for-gametes-and-embryos-which-culture-medium-which-impact-on-newborn
#9
I Koscinski, M Merten, N Kazdar, J-L Guéant
Many studies have examined the impact of cell/embryo culture media on the development of human embryo during IVF process, but few studies have followed up and compared the effects of these culture media on the developmental outcome of children conceived by IVF. As recurrent experimental evidence from animal studies suggests potential long-term effects of embryo culture media on the health outcome of IVF-conceived children, more studies are needed to clarify the role of the culture media and mechanisms underlying such effects...
April 27, 2018: Gynecologie, Obstetrique, Fertilite & Senologie
https://www.readbyqxmd.com/read/29706028/emerging-concepts-on-the-role-of-epigenetics-in-the-relationships-between-nutrition-and-health
#10
REVIEW
P J Stover, W P T James, A Krook, C Garza
Understanding the physiological and metabolic underpinnings that confer individual differences in responses to diet and diet-related chronic disease is essential to advance the field of nutrition. This includes elucidating the differences in gene expression that are mediated through programming of the genome through epigenetic chromatin modifications. Epigenetic landscapes are influenced by age, genetics, toxins and other environmental factors, including dietary exposures and nutritional status. Epigenetic modifications influence transcription and genome stability, are established during development with life-long consequences...
April 29, 2018: Journal of Internal Medicine
https://www.readbyqxmd.com/read/29705428/adsa-foundation-scholar-award-a-role-for-serotonin-in-lactation-physiology-where-do-we-go-from-here
#11
L L Hernandez
Lactation is a physiological event that is exclusive to mammals. Lactation evolved as a strategy to improve the survival of the young by providing them with the complete nutrition that is required for survival upon birth as well as maternal-offspring bonding. Typically, milk production by the dam matches the demand of the young. The dairy cow is a unique exception in which the discoveries and genetic selection related to lactation physiology have been applied and resulted in a dramatic increase in milk yield of dairy cows...
April 25, 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29693637/paltem-what-parameters-should-be-collected-in-disaster-settings-to-assess-the-long-term-outcomes-of-famine
#12
REVIEW
Alexandra Moraru, Maria Moitinho de Almeida, Jean-Marie Degryse
Evidence suggests that nutritional status during fetal development and early life leaves an imprint on the genome, which leads to health outcomes not only on a person as an adult but also on his offspring. The purpose of this study is to bring forth an overview of the relevant parameters that need to be collected to assess the long-term and transgenerational health outcomes of famine. A literature search was conducted for the most pertinent articles on the epigenetic effects of famine. The results were compiled, synthesized and discussed with an expert in genetics for critical input and validation...
April 25, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29692252/epigenetics-nutrition-disease-and-drug-development
#13
Kenneth Lundstrom
Epigenetic mechanisms comprising of DNA methylation, histone modifications and gene silencing by RNA interference have been strongly linked to the development and progression of various diseases. These findings have triggered research on epigenetic functions and signal pathways as targets for novel drug discovery. Dietary intake has also presented significant influence on human health and disease development and nutritional modifications have proven important in prevention, but also treatment of disease. Moreover, a strong link between nutrition and epigenetic changes has been established...
April 19, 2018: Current Drug Discovery Technologies
https://www.readbyqxmd.com/read/29687201/folate-promotes-s-adenosyl-methionine-reactions-and-the-microbial-methylation-cycle-and-boosts-ruminants-production-and-reproduction
#14
REVIEW
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Lamei Wang, Mohamed E Abd El Hack, Ayman A Swelum, Ren Hao, Junhu Yao, Yangchun Cao
Folate has gained significant attention due to its vital role in biological methylation and epigenetic machinery. Folate, or vitamin (B9 ), is only produced through a de novo mechanism by plants and micro-organisms in the rumen of mature animals. Although limited research has been conducted on folate in ruminants, it has been noted that ruminal synthesis could not maintain folate levels in high yielding dairy animals. Folate has an essential role in one-carbon metabolism and is a strong antiproliferative agent...
April 23, 2018: AMB Express
https://www.readbyqxmd.com/read/29686491/early-life-environment-and-social-determinants-of-cardiac-health-in-children-with-congenital-heart-disease
#15
REVIEW
Peter Wong, Avram Denburg, Malini Dave, Leo Levin, Julia Orkin Morinis, Shazeen Suleman, Jonathan Wong, Elizabeth Ford-Jones, Aideen M Moore
Congenital heart disease is a significant cause of infant mortality. Epidemiology and social context play a crucial role in conditioning disease burden and modulating outcomes, while diagnosis and treatment remain resource intensive. This review will address the role of social demographics, environmental exposure, epigenetics and nutrition in the aetiology of congenital heart disease. We then discuss the determinant effect of social factors on the provision and outcomes of care for congenital heart disease and implications for practice...
April 2018: Paediatrics & Child Health
https://www.readbyqxmd.com/read/29680662/insulin-sensitivity-linked-skeletal-muscle-nr4a1-dna-methylation-is-programmed-by-the-maternal-diet-and-modulated-by-voluntary-exercise-in-mice
#16
Juliane Kasch, Isabel Kanzleiter, Sophie Saussenthaler, Annette Schürmann, Jaap Keijer, Evert van Schothorst, Susanne Klaus, Sara Schumann
Perinatal maternal high-fat consumption is known to increase the obesity and type 2 diabetes susceptibility and to impair exercise performance in the offspring. We hypothesize that epigenetic modifications in the skeletal muscle are partly responsible for this phenotype. To detect skeletal muscle genes affected by maternal nutrition, male offspring of low-fat (LF) and high-fat (HF) diet fed dams (BL6 mice) received LF diet upon weaning and were sacrificed at 6 or 25 weeks of age. Gene expression of Musculus quadriceps was investigated by microarray analysis revealing an up-regulation of the nuclear receptor Nr4a1 by maternal HF feeding...
March 21, 2018: Journal of Nutritional Biochemistry
https://www.readbyqxmd.com/read/29679395/placental-adaptations-to-micronutrient-dysregulation-in-the-programming-of-chronic-disease
#17
Pierre Hofstee, Daniel McKeating, Anthony V Perkins, James S M Cuffe
Poor nutrition during pregnancy is known to impair foetal development and increase the risk of chronic disease in offspring. Both macronutrients and micronutrients are required for a healthy pregnancy although significantly less is understood about the role of micronutrients in the programming of chronic disease. This is despite the fact that modern calorie rich diets are often also deficient in key micronutrients. The importance of micronutrients in gestational disorders is clearly understood but how they impact long term disease in humans requires further investigation...
April 21, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29627813/pathways-of-association-between-maternal-haemoglobin-and-stillbirth-path-analysis-of-maternity-data-from-two-hospitals-in-england
#18
Manisha Nair, Marian Knight, Susan Robinson, Catherine Nelson-Piercy, Simon J Stanworth, David Churchill
OBJECTIVE: To investigate the mechanisms that link maternal haemoglobin concentration with stillbirth. DESIGN: A retrospective cohort analysis using anonymised maternity data from two hospitals in England. SETTING: The Royal Wolverhampton NHS Trust and Guy's and St Thomas' NHS Foundation Trust. STUDY POPULATION: 12 636 women with singleton pregnancies ≥24 weeks of gestation giving birth in the two hospitals during 2013-2015...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29619646/-sarcopenia-and-frailty-in-older-patients-with-rheumatism
#19
U Lange
Sarcopenia is an age-related generalized loss of muscle mass and muscle strength resulting in low physical performance, which can be observed in up to 50% of >80-year-old individuals. The consequences are manifold and sarcopenia is closely linked to frailty. Important risk factors are genetics/epigenetics, immobilization, malnutrition and anorexia, hormone deficiencies, chronic inflammation and raised levels of inhibitory factors of tissue regeneration. Thus, functional assessment of muscle strength and physical performance are central components of diagnosing sarcopenia, beyond the mere quantification of muscle mass...
April 4, 2018: Zeitschrift Für Rheumatologie
https://www.readbyqxmd.com/read/29587831/childhood-fish-oil-supplementation-modifies-associations-between-traffic-related-air-pollution-and-allergic-sensitisation
#20
Anna L Hansell, Ioannis Bakolis, Christine T Cowie, Elena G Belousova, Kitty Ng, Christina Weber-Chrysochoou, Warwick J Britton, Stephen R Leeder, Euan R Tovey, Karen L Webb, Brett G Toelle, Guy B Marks
BACKGROUND: Studies of potential adverse effects of traffic related air pollution (TRAP) on allergic disease have had mixed findings. Nutritional studies to examine whether fish oil supplementation may protect against development of allergic disease through their anti-inflammatory actions have also had mixed findings. Extremely few studies to date have considered whether air pollution and dietary factors such as fish oil intake may interact, which was the rationale for this study. METHODS: We conducted a secondary analysis of the Childhood Asthma Prevention Study (CAPS) birth cohort, where children were randomised to fish oil supplementation or placebo from early life to age 5 years...
March 27, 2018: Environmental Health: a Global Access Science Source
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