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Nutrition epigenetics

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https://www.readbyqxmd.com/read/28806274/transfusion-related-immunomodulation-a-reappraisal
#1
Lyla A Youssef, Steven L Spitalnik
PURPOSE OF REVIEW: This review summarizes current and prior observations regarding transfusion-related immunomodulation (TRIM) and puts these ideas into a modern immunological context, incorporating concepts from innate, adaptive, and nutritional immunity. We propose that TRIM research focus on determining whether there are specific, well-defined immunosuppressive effects from transfusing 'pure' red blood cells (RBCs) themselves, along with the by-products produced by the stored RBCs as a result of the 'storage lesion...
August 12, 2017: Current Opinion in Hematology
https://www.readbyqxmd.com/read/28796169/cell-surface-and-nuclear-receptors-in-the-colon-as-targets-for-bacterial-metabolites-and-its-relevance-to-colon-health
#2
REVIEW
Sathish Sivaprakasam, Yangzom D Bhutia, Sabarish Ramachandran, Vadivel Ganapathy
The symbiotic co-habitation of bacteria in the host colon is mutually beneficial to both partners. While the host provides the place and food for the bacteria to colonize and live, the bacteria in turn help the host in energy and nutritional homeostasis, development and maturation of the mucosal immune system, and protection against inflammation and carcinogenesis. In this review, we highlight the molecular mediators of the effective communication between the bacteria and the host, focusing on selective metabolites from the bacteria that serve as messengers to the host by acting through selective receptors in the host colon...
August 10, 2017: Nutrients
https://www.readbyqxmd.com/read/28769760/implications-of-dna-methylation-in-parkinson-s-disease
#3
REVIEW
Ernesto Miranda-Morales, Karin Meier, Ada Sandoval-Carrillo, José Salas-Pacheco, Paola Vázquez-Cárdenas, Oscar Arias-Carrión
It has been 200 years since Parkinson's disease (PD) was first described, yet many aspects of its etiopathogenesis remain unclear. PD is a progressive and complex neurodegenerative disorder caused by genetic and environmental factors including aging, nutrition, pesticides and exposure to heavy metals. DNA methylation may be altered in response to some of these factors; therefore, it is proposed that epigenetic mechanisms, particularly DNA methylation, can have a fundamental role in gene-environment interactions that are related with PD...
2017: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/28764817/the-rpmi-1640-vitamin-mixture-promotes-bovine-blastocyst-development-in-vitro-and-downregulates-gene-expression-of-txnip-with-epigenetic-modification-of-associated-histones
#4
S Ikeda, M Sugimoto, S Kume
Diverse environmental conditions surrounding preimplantation embryos, including available nutrients, affect their metabolism and development in both short- and long-term manner. Thioredoxin-interacting protein (TXNIP) is a possible marker for preimplantation stress that is implicated in in vitro fertilization- (IVF) induced long-term DOHaD effects. B vitamins, as participants in one-carbon metabolism, may affect preimplantation embryos by epigenetic alterations of metabolically and developmentally important genes...
August 2, 2017: Journal of Developmental Origins of Health and Disease
https://www.readbyqxmd.com/read/28715062/gestational-weight-gain-historical-evolution-of-a-contested-health-outcome
#5
Edmond D Shenassa, Celena Kinsey, Marian Moser Jones, Jenifer Fahey
The history of research on gestational weight gain (GWG) in the United States and United Kingdom provides a context for current clinical practice. We trace the evolution of research on GWG in scientific literature from the 19th century to the present and examine its implications for contemporary clinical and public health practice. Obstetricians, beginning in the late 1800s, recommended dieting during pregnancy in order to limit GWG to 20 lb or less, driven by a belief that excessive weight gain was a cause of toxemia...
July 2017: Obstetrical & Gynecological Survey
https://www.readbyqxmd.com/read/28708104/fruit-and-juice-epigenetic-signatures-are-associated-with-independent-immunoregulatory-pathways
#6
Jessie Nicodemus-Johnson, Robert A Sinnott
Epidemiological evidence strongly suggests that fruit consumption promotes many health benefits. Despite the general consensus that fruit and juice are nutritionally similar, epidemiological results for juice consumption are conflicting. Our objective was to use DNA methylation marks to characterize fruit and juice epigenetic signatures within PBMCs and identify shared and independent signatures associated with these groups. Genome-wide DNA methylation marks (Illumina Human Methylation 450k chip) for 2,148 individuals that participated in the Framingham Offspring exam 8 were analyzed for correlations between fruit or juice consumption using standard linear regression...
July 14, 2017: Nutrients
https://www.readbyqxmd.com/read/28702424/epigenetics-linking-nutrition-to-molecular-mechanisms-in-aging
#7
REVIEW
Joo Hyun Park, Yeongran Yoo, Yoon Jung Park
Healthy aging has become a major goal of public health. Many studies have provided evidence and theories to explain molecular mechanisms of the aging process. Recent studies suggest that epigenetic mechanisms are responsible for life span and the progression of aging. Epigenetics is a fascinating field of molecular biology, which studies heritable modifications of DNA and histones that regulate gene expression without altering the DNA sequence. DNA methylation is a major epigenetic mark that shows progressive changes during aging...
June 2017: Preventive Nutrition and Food Science
https://www.readbyqxmd.com/read/28689206/guide-for-current-nutrigenetic-nutrigenomic-and-nutriepigenetic-approaches-for-precision-nutrition-involving-the-prevention-and-management-of-chronic-diseases-associated-with-obesity
#8
Omar Ramos-Lopez, Fermín I Milagro, Hooman Allayee, Agata Chmurzynska, Myung Sook Choi, Rui Curi, Raffaele De Caterina, Lynnette R Ferguson, Leticia Goni, Jing X Kang, Martin Kohlmeier, Amelia Marti, Luis A Moreno, Louis Pérusse, Chandan Prasad, Lu Qi, Ram Reifen, Jose I Riezu-Boj, Rodrigo San-Cristobal, Jose Luis Santos, J Alfredo Martínez
Chronic diseases, including obesity, are major causes of morbidity and mortality in most countries. The adverse impacts of obesity and associated comorbidities on health remain a major concern due to the lack of effective interventions for prevention and management. Precision nutrition is an emerging therapeutic approach that takes into account an individual's genetic and epigenetic information, as well as age, gender, or particular physiopathological status. Advances in genomic sciences are contributing to a better understanding of the role of genetic variants and epigenetic signatures as well as gene expression patterns in the development of diverse chronic conditions, and how they may modify therapeutic responses...
July 8, 2017: Journal of Nutrigenetics and Nutrigenomics
https://www.readbyqxmd.com/read/28684678/maternal-macronutrient-consumption-and-the-developmental-origins-of-metabolic-disease-in-the-offspring
#9
REVIEW
Stephanie M Kereliuk, Gabriel M Brawerman, Vernon W Dolinsky
Recent research aimed at understanding the rise in obesity and cardiometabolic disease in children suggests that suboptimal maternal nutrition conditions organ systems and physiological responses in the offspring contributing to disease development. Understanding the mechanisms by which the macronutrient composition of the maternal diet during pregnancy or lactation affects health outcomes in the offspring may lead to new maternal nutrition recommendations, disease prevention strategies and therapies that reduce the increasing incidence of cardiometabolic disease in children...
July 6, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28679412/impact-of-body-size-nutrition-and-socioeconomic-position-in-early-life-on-the-epigenome-a-systematic-review-protocol
#10
Jane Maddock, Wahyu Wulaningsih, Rebecca Hardy
BACKGROUND: Body size, nutrition and socioeconomic position (SEP) in early life have been associated with a range of later life health outcomes. Epigenetic regulation is one mechanism through which these early life factors may impact later life health. The aim of this review protocol is to outline procedures to document the influence of body size, nutrition and SEP in early life on the epigenome. METHODS: MEDLINE, Embase and BIOSIS will be systematically searched using pre-defined keywords...
July 5, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/28673994/social-and-physical-environments-early-in-development-predict-dna-methylation-of-inflammatory-genes-in-young-adulthood
#11
Thomas W McDade, Calen Ryan, Meaghan J Jones, Julia L MacIsaac, Alexander M Morin, Jess M Meyer, Judith B Borja, Gregory E Miller, Michael S Kobor, Christopher W Kuzawa
Chronic inflammation contributes to a wide range of human diseases, and environments in infancy and childhood are important determinants of inflammatory phenotypes. The underlying biological mechanisms connecting early environments with the regulation of inflammation in adulthood are not known, but epigenetic processes are plausible candidates. We tested the hypothesis that patterns of DNA methylation (DNAm) in inflammatory genes in young adulthood would be predicted by early life nutritional, microbial, and psychosocial exposures previously associated with levels of inflammation...
July 18, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28673078/nutritional-and-metabolic-programming-during-the-first-thousand-days-of-life
#12
Massimo Agosti, Francesco Tandoi, Laura Morlacchi, Angela Bossi
The latest scientific acquisitions are demonstrating what has already been hypothesized for more than twenty years about the development of the state of health/illness of individuals. Indeed, certain stimuli, if applied to a sensible phase of development, are able to modify, through epigenetic mechanisms, gene expression of DNA, resulting in adaptive modifications of phenotype to the environment, which may reflect negatively on the health of every individual. This concept, applied to nutrition, has opened up important prospects for research in this area...
June 28, 2017: La Pediatria Medica e Chirurgica: Medical and Surgical Pediatrics
https://www.readbyqxmd.com/read/28665177/epigenetics-and-adhd-toward-an-integrative-approach-of-the-disorder-pathogenesis
#13
Meriem Hamza, Soumeyya Halayem, Soumaya Bourgou, Mona Daoud, Fatma Charfi, Ahlem Belhadj
OBJECTIVE: Epigenetic hypothesis is one of the research pathways used to explain the complex etiology of neurodevelopmental disorders. This review highlights the findings of recent studies in the field of epigenetics in ADHD. METHODS: An electronic literature search using Medline. RESULTS: In the Gene × Environment interaction model, several clinical, genetic and molecular arguments support the epigenetic hypothesis in ADHD etiology. Environmental ADHD risk factors including toxic, nutritional factors and stressful life events lead to changes in DNA methylation and in histone modification levels...
March 1, 2017: Journal of Attention Disorders
https://www.readbyqxmd.com/read/28661576/physiological-alterations-associated-with-intrauterine-growth-restriction-in-fetal-pigs-causes-and-insights-for-nutritional-optimization
#14
REVIEW
Junjun Wang, Cuiping Feng, Ting Liu, Meng Shi, Guoyao Wu, Fuller W Bazer
Intrauterine growth restriction (IUGR) remains a major problem in swine production since the associated low birth weight leads to high rates of pre-weaning morbidity and mortality plus permanent retardation of growth and development. Complex biological events-including genetics, epigenetics, maternal maturity, maternal nutrition, placenta efficiency, uterine capacity, and other environmental factors-can affect fetal growth and development during late gestation, as well as maturity of oocytes, duration of estrus, and both implantation and placentation of conceptuses in uteri of sows...
June 29, 2017: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/28658611/interventions-to-slow-cardiovascular-aging-dietary-restriction-drugs-and-novel-molecules
#15
REVIEW
Christian Heiss, Ioakim Spyridopoulos, Judith Haendeler
Cardiovascular aging is a highly dynamic process. Despite the fact that cardiovascular function and structure change with age, they can still be modulated even in aged humans. The most prominent approaches to improve age-dependent vascular changes include dietary restriction and pharmacologic agents interacting with signaling pathways implicated in this context. These include inhibition of TOR, glycolysis, and GH/IGF-1, activation of sirtuins, and AMPK, as well as modulators of inflammation, epigenetic pathways, and telomeres...
June 27, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28658542/the-nutrition-gut-microbiome-physiology-axis-and-allergic-diseases
#16
REVIEW
Craig McKenzie, Jian Tan, Laurence Macia, Charles R Mackay
Dietary and bacterial metabolites influence immune responses. This raises the question whether the increased incidence of allergies, asthma, some autoimmune diseases, cardiovascular disease, and others might relate to intake of unhealthy foods, and the decreased intake of dietary fiber. In recent years, new knowledge on the molecular mechanisms underpinning a 'diet-gut microbiota-physiology axis' has emerged to substantiate this idea. Fiber is fermented to short chain fatty acids (SCFAs), particularly acetate, butyrate, and propionate...
July 2017: Immunological Reviews
https://www.readbyqxmd.com/read/28654021/vitamin-c-aging-and-alzheimer-s-disease
#17
REVIEW
Fiammetta Monacelli, Erica Acquarone, Chiara Giannotti, Roberta Borghi, Alessio Nencioni
Accumulating evidence in mice models of accelerated senescence indicates a rescuing role of ascorbic acid in premature aging. Supplementation of ascorbic acid appeared to halt cell growth, oxidative stress, telomere attrition, disorganization of chromatin, and excessive secretion of inflammatory factors, and extend lifespan. Interestingly, ascorbic acid (AA) was also found to positively modulate inflamm-aging and immunosenescence, two hallmarks of biological aging. Moreover, ascorbic acid has been shown to epigenetically regulate genome integrity and stability, indicating a key role of targeted nutrition in healthy aging...
June 27, 2017: Nutrients
https://www.readbyqxmd.com/read/28640886/epigenomic-diversification-within-the-genus-lupinus
#18
Karolina Susek, Agnieszka Braszewska-Zalewska, Adam J Bewick, Robert Hasterok, Robert J Schmitz, Barbara Naganowska
Deciphering the various chemical modifications of both DNA and the histone compound of chromatin not only leads to a better understanding of the genome-wide organisation of epigenetic landmarks and their impact on gene expression but may also provide some insights into the evolutionary processes. Although both histone modifications and DNA methylation have been widely investigated in various plant genomes, here we present the first study for the genus Lupinus. Lupins, which are members of grain legumes (pulses), are beneficial for food security, nutrition, health and the environment...
2017: PloS One
https://www.readbyqxmd.com/read/28635106/long-noncoding-rna-and-its-contribution-to-autism-spectrum-disorders
#19
REVIEW
Jie Tang, Yizhen Yu, Wei Yang
Recent studies have indicated that long noncoding RNAs (lncRNAs) play important roles in multiple processes, such as epigenetic regulation, gene expression regulation, development, nutrition-related and other diseases, toxic response, and response to drugs. Although the functional roles and mechanisms of several lncRNAs have been discovered, a better understanding of the vast majority of lncRNAs remains elusive. To understand the functional roles and mechanisms of lncRNAs is critical because these transcripts represent the majority of the transcriptional output of the mammalian genome...
August 2017: CNS Neuroscience & Therapeutics
https://www.readbyqxmd.com/read/28631291/folate-deficiency-disturbs-hsa-let-7-g-level-through-methylation-regulation-in-neural-tube-defects
#20
Li Wang, Shaofang Shangguan, Yu Xin, Shaoyan Chang, Zhen Wang, Xiaolin Lu, Lihua Wu, Bo Niu, Ting Zhang
Folic acid deficiency during pregnancy is believed to be a high-risk factor for neural tube defects (NTDs). Disturbed epigenetic modifications, including miRNA regulation, have been linked to the pathogenesis of NTDs in those with folate deficiency. However, the mechanism by which folic acid-regulated miRNA influences this pathogenesis remains unclear. It is believed that DNA methylation is associated with dysregulated miRNA expression. To clarify this issue, here we measured the methylation changes of 22 miRNAs in 57 human NTD cases to explore whether such changes are involved in miRNA regulation in NTD cases through folate metabolism...
June 19, 2017: Journal of Cellular and Molecular Medicine
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