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https://www.readbyqxmd.com/read/28176950/circulating-monocytes-and-b-lymphocytes-in-neovascular-age-related-macular-degeneration
#1
Sven Magnus Hector, Torben Lykke Sørensen
BACKGROUND: Individuals with neovascular age-related macular degeneration (AMD) have altered number and distribution of retinal macrophages and show changes in circulating antibodies. We wanted to investigate the corresponding precursors, with subpopulations. We therefore measured monocyte and B-lymphocyte populations in individuals with neovascular AMD. DESIGN: This was an observational case-control study. PARTICIPANTS OR SAMPLES: A total of 31 individuals with neovascular AMD and 30 healthy age-matched controls were included...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28125501/good-visual-outcome-in-a-bilateral-multifocal-syphilitic-chorioretinitis-despite-late-diagnosis
#2
Ricardo Evangelista Marrocos de Aragao, Ieda Maria Alexandre Barreira, Cristina Muccioli, Gustavo Jose Arruda Mendes Carneiro, Cesar Pereira de Araujo, Everton Fernandes Vieira de Almeida, Talles Peterson Cavalcante Oria, Nayara Queiroz Cardoso Pinto, Jhonatan de Paula Araujo Ferreira
PURPOSE: To report a case of a good visual outcome in a patient with bilateral multifocal syphilitic chorioretinitis, despite the late diagnosis. METHODS: Ophthalmologic examination, multimodal imaging, including fundus photography, angiography, and optical coherence tomography. RESULTS: The authors describe a 47-year-old heterosexual man with a bilateral multifocal syphilitic chorioretinitis that was lately diagnosed and despite that had a good visual outcome...
January 24, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28095086/retinal-findings-and-a-novel-tinf2-mutation-in-revesz-syndrome-clinical-and-molecular-correlations-with-pediatric-retinal-vasculopathies
#3
Mrinali P Gupta, Katherine E Talcott, David Y Kim, Suneet Agarwal, Shizuo Mukai
BACKGROUND: Revesz syndrome is a telomere disorder in the dyskeratosis congenita (DKC) spectrum characterized by exudative retinopathy, bone marrow failure, neuroradiographic abnormalities, and integumentary findings. MATERIALS/METHODS: We report the ophthalmologic findings, documented by examinations under anesthesia with clinical photography and fluorescein angiography, as well as the systemic manifestations and genetic and molecular testing, in identical twins with Revesz syndrome, and compare and contrast these features to those of other pediatric retinal vasculopathies...
January 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28088509/choroidal-neovascularization-in-malattia-leventinese-diagnosed-using-optical-coherence-tomography-angiography
#4
Rita Serra, Florence Coscas, Nabil Messaoudi, Mayer Srour, Eric Souied
PURPOSE: To compare Optical Coherence Tomography Angiography (OCT-A) with traditional multimodal imaging in patients with Malattia Leventinese DESIGN: Retrospective case series. METHODS: Eight eyes of four consecutive patients with Malattia Leventinese were retrospectively studied. All patients underwent a complete ophthalmological examination including color fundus photography, fluorescein and indocyanine green angiographies, Spectral Domain Optical Coherence Tomography and Optical Coherence Tomography Angiography...
January 11, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28060137/infants-with-congenital-zika-syndrome-and-ocular-findings-from-s%C3%A3-o-paulo-brazil-spread-of-infection
#5
João Rafael de Oliveira Dias, Camila V Ventura, Paula Delegrego Borba, Bruno de Paula Freitas, Ligia Camera Pierroti, Ana Patricia do Nascimento, Nilva Simeren Bueno de Moraes, Maurício Maia, Rubens Belfort
BACKGROUND/PURPOSE: To describe the ocular findings of two infants with congenital Zika syndrome born in São Paulo state, Brazil, outside the primary outbreak region. METHODS: Two female infants with congenital Zika syndrome were submitted to a complete screening for infectious diseases, as well as ocular examination, fundus photography, and optical coherence tomography of the retina. One of the infants was submitted to ocular ultrasound. RESULTS: Both children showed positive serology for Zika virus, and other infectious diseases were ruled out...
January 2, 2017: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/28058165/evaluation-of-follow-up-and-treatment-results-in-coats-disease
#6
Zafer Cebeci, Şerife Bayraktar, Yusuf Cem Yılmaz, Samuray Tuncer, Nur Kır
OBJECTIVES: The aim of this study was to evaluate the clinical features, follow-up and treatment results of patients diagnosed with Coats' disease. MATERIALS AND METHODS: Medical records of 27 patients diagnosed with Coats' disease in our clinic were reviewed retrospectively. All patients underwent complete ophthalmological examination and fundus photography was taken. Disease stage and treatment methods used were recorded. RESULTS: Twenty-seven eyes of 27 patients were included in the study...
October 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/28058151/characteristics-of-fundus-autofluorescence-in-active-polypoidal-choroidal-vasculopathy
#7
Zafer Öztaş, Jale Menteş, Serhad Nalçacı, Mine Barış
OBJECTIVES: To define characteristic fundus autofluorescence (FAF) findings in eyes with active polypoidal choroidal vasculopathy (PCV). MATERIALS AND METHODS: Thirty-five eyes of 29 patients with active PCV who were diagnosed at Ege University Faculty of Medicine, Department of Ophthalmology, Retina Division between January 2012 and November 2014 were included in the study. All the patients underwent a complete ophthalmological examination including fundus photography, spectral-domain optical coherence tomography, fluorescein angiography, FAF photography, and indocyanine green angiography (ICGA)...
August 2016: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/27966268/ophthalmological-findings-in-children-with-encephalitis
#8
Kerstin Hellgren, Åsa Fowler, Agneta Rydberg, Ronny Wickström
PURPOSE: To evaluate ophthalmological abnormalities in children with acute encephalitis. METHODS: Thirty-six children included in a hospital-based prospectively and consecutively collected cohort of children with acute encephalitis were investigated for ophthalmological abnormalities. The investigation included clinical ophthalmological examination, fundus photography, neuro-ophthalmological examinations as well as visual and stereo acuity. Results on laboratory examinations, clinical findings, neuroimaging and electroencephalography registrations were recorded for all children...
February 2017: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27938959/six-year-prevalence-and-incidence-of-diabetic-retinopathy-and-cost-effectiveness-of-tele-ophthalmology-in-manitoba
#9
Raageen Kanjee, Ravi I Dookeran, Mathen K Mathen, Frank A Stockl, Richard Leicht
OBJECTIVE: The purpose of this study was to evaluate the diabetic retinopathy (DR) tele-ophthalmology screening program in Manitoba to determine prevalence and incidence of DR, as well as to estimate the program's cost-effectiveness. DESIGN: Retrospective chart review. PARTICIPANTS: A total of 4676 patients with type 2 diabetes examined 9334 times from 2007 to 2013. METHODS: Focused ophthalmic histories were recorded and examinations were performed by trained nurses, including visual acuities, intraocular pressure, and mydriatic 7 standard field stereoscopic fundus photography...
December 2016: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/27907042/role-of-platelet-parameters-on-neovascular-glaucoma-a-retrospective-case-control-study-in-china
#10
Shengjie Li, Wenjun Cao, Xinghuai Sun
PURPOSE: Retinal vein occlusion (RVO) and diabetic retinopathy (DR) are two major sight-threatening diseases which may lead to neovascular glaucoma (NVG). The aim of this study was to explore the association between platelet parameters and NVG. METHODS: A total of 185 subjects were enrolled for the study from January, 2012 to December, 2015 at the Eye-ENT Hospital of Fudan University. Patients include those with NVG secondary to RVO (RVO group, n = 38), patients with NVG secondary to DR (DR group, n = 47), diabetics mellitus without retinopathy (DM group, n = 52), and healthy individuals (control group, n = 48)...
2016: PloS One
https://www.readbyqxmd.com/read/27802518/diagnostic-performance-of-peripapillary-retinal-nerve-fiber-layer-thickness-for-detection-of-glaucoma-in-an-elderly-population-the-alienor-study
#11
Cedric Schweitzer, Jean-Francois Korobelnik, Melanie Le Goff, Olivier Rahimian, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Jean-Francois Dartigues, Cecile Delcourt
Purpose: To assess diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) to discriminate glaucoma and control subjects in an elderly population. Methods: The antioxidants, essential lipids, nutrition and ocular maladies study (ALIENOR: "Antioxydants, Lipides Essentiels, Nutrition et Maladies Oculaires") is a population-based study. From 2009 to 2010, a total of 624 subjects, aged 74 years or older underwent a complete eye examination, including optic disc color photography and SD-OCT examination of the macula and the optic nerve head...
November 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27778447/distribution-of-intraocular-pressure-central-corneal-thickness-and-vertical-cup-to-disc-ratio-in-a-healthy-iranian-population-the-yazd-eye-study
#12
Mohammad Pakravan, Mohammad Ali Javadi, Shahin Yazdani, Elham Ghahari, Zohreh Behroozi, Reza Soleimanizad, Sasan Moghimi, Naveed Nilforoushan, Reza Zarei, Yadollah Eslami, Mahmood Ghassami, Hossein Ziaei, Marzieh Katibeh, Hanif Tabesh, Mehdi Yaseri
PURPOSE: To determine the distribution of intraocular pressure (IOP), central corneal thickness (CCT) and vertical cup-to-disc ratio (VCDR) in the healthy Iranian population. METHODS: This population-based, epidemiologic study evaluated Iranian aged 40-80 years, residing in Yazd, Iran, in 2010-2011. Eligible subjects were selected by cluster random sampling. Each participant underwent an interview and ophthalmologic examination including slit lamp examination, Goldmann applanation tonometry, binocular optic disc evaluation, stereoscopic fundus photography, ultrasonic pachymetry and visual field testing...
October 25, 2016: Acta Ophthalmologica
https://www.readbyqxmd.com/read/27685535/influence-of-computer-generated-mosaic-photographs-on-retinopathy-of-prematurity-diagnosis-and-management
#13
Samir N Patel, Michael A Klufas, Christina E Douglas, Karyn E Jonas, Susan Ostmo, Audina Berrocal, Antonio Capone, Maria A Martinez-Castellanos, Felix Chau, Kimberly Drenser, Philip Ferrone, Anton Orlin, Irena Tsui, Wei-Chi Wu, Mrinali P Gupta, Michael F Chiang, R V Paul Chan
Importance: Telemedicine is becoming an increasingly important component of clinical care for retinopathy of prematurity (ROP), but little information exists regarding the role of mosaic photography for ROP telemedicine diagnosis. Objective: To examine the potential effect of computer-generated mosaic photographs on the diagnosis and management of ROP. Design, Setting, and Participants: In this prospective cohort study performed from July 12, 2011, through September 21, 2015, images were acquired from ROP screening at 8 academic institutions, and ROP experts interpreted 40 sets (20 sets with individual fundus photographs with ≥3 fields and 20 computer-generated mosaic photographs) of wide-angle retinal images from infants with ROP...
November 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27628287/-handheld-optical-coherence-tomography-in-paediatric-ophthalmology-experience-of-the-department-of-ophthalmology-in-giessen
#14
W Bowl, M Andrassi-Darida, K Holve, S Schweinfurth, R Knobloch, B Lorenz
Introduction: Optical coherence tomography is an important tool for the imaging and analysis of retinal structures. The usability of conventional table-top devices is limited in children. We report on our experiences with a handheld Spectral Domain Optical Coherence Tomography (HH-SD-OCT, Bioptigen™) in infants and young children in our daily practice. Methods: Between October 2014 and April 2016, we investigated 259 patients. Indications and diagnoses were assessed. Individual examples are shown to demonstrate the advantages and disadvantages of the novel technique...
October 2016: Klinische Monatsblätter Für Augenheilkunde
https://www.readbyqxmd.com/read/27584715/effect-of-a-matrix-therapy-agent-on-corneal-epithelial-healing-after-standard-collagen-cross-linking-in-patients-with-keratoconus-a-randomized-clinical-trial
#15
Ahmed M Bata, Katarzyna J Witkowska, Piotr A Wozniak, Klemens Fondi, Gerald Schmidinger, Niklas Pircher, Stephan Szegedi, Valentin Aranha Dos Santos, Anca Pantalon, René M Werkmeister, Gerhard Garhofer, Leopold Schmetterer, Doreen Schmidl
Importance: Corneal abrasions are frequent after standard (epithelium-off [epi-off]) corneal collagen cross-linking (CXL) in patients with progressive keratoconus. A new matrix therapy agent (ReGeneraTing Agent [RGTA]) has been developed to promote corneal wound healing. Objective: To assess the effect of the new type of matrix therapy agent on corneal wound healing after epi-off CXL in patients with keratoconus. Design, Setting, and Participants: This double-masked randomized clinical trial enrolled 40 patients with keratoconus undergoing epi-off CXL from July 18, 2014, to October 21, 2015, when the last follow-up was completed...
October 1, 2016: JAMA Ophthalmology
https://www.readbyqxmd.com/read/27537414/retinal-sequelae-in-adults-treated-with-cryotherapy-for-retinopathy-of-prematurity
#16
Maria Nilsson, Ann Hellström, Lena Jacobson
PURPOSE: Cryotherapy, introduced in the mid-1980s, was the first treatment of severe retinopathy of prematurity (ROP) and resulted in ablation of larger retinal areas than did its later substitute, laser treatment. We defined the characteristics of the retinal structure and assessed visual function, in adult ex-preterms treated with cryotherapy. METHODS: A total of 28 ex-preterms, included in a prospective study of infants born in Stockholm between September 1988 and March 1993, were treated with cryotherapy because of severe ROP...
July 1, 2016: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/27529778/intravitreal-methotrexate-for-mantle-cell-lymphoma-infiltration-of-the-optic-nerves-a-case-report
#17
James R Singer, Archana K Nigalye, Mary T Champion, Matthew J Welch
PURPOSE: To report the successful treatment of a 78-year-old woman with bilateral mantle cell lymphoma involving the optic nerves. Chemotherapy initially was administered in the form of intravitreal methotrexate (MTX) monotherapy and was subsequently combined with systemic ibrutinib. METHODS: Retrospective case report. The diagnosis of CD5-negative mantle cell lymphoma was confirmed via immunohistopathological analysis of an axillary lymph node. Serial ophthalmologic examinations in conjunction with fluorescein angiography, fundus photography, and spectral domain optical coherence tomography were used to assess the treatment response...
August 12, 2016: Retinal Cases & Brief Reports
https://www.readbyqxmd.com/read/27521170/clinical-and-genetic-characteristics-of-japanese-patients-with-age-related-macular-degeneration-and-pseudodrusen
#18
Sufian Elfandi, Sotaro Ooto, Naoko Ueda-Arakawa, Ayako Takahashi, Munemitsu Yoshikawa, Hideo Nakanishi, Hiroshi Tamura, Akio Oishi, Kenji Yamashiro, Nagahisa Yoshimura
PURPOSE: To investigate differences in clinical characteristics and genotype distribution in Japanese patients with age-related macular degeneration (AMD) and pseudodrusen using multimodal imaging. DESIGN: Retrospective, observational case series. PARTICIPANTS: A total of 101 patients (101 eyes) with AMD and pseudodrusen. METHODS: Patients underwent complete ophthalmologic examination, including color fundus photography, infrared reflectance (IR) imaging, fundus autofluorescence, confocal blue reflectance, fluorescein and indocyanine green (ICG) angiography, and spectral-domain optical coherence tomography (SD OCT)...
October 2016: Ophthalmology
https://www.readbyqxmd.com/read/27486012/ocular-morphology-and-function-in-juvenile-neuronal-ceroid-lipofuscinosis-cln3-in-the-first-decade-of-life
#19
Markus N Preising, Michaela Abura, Melanie Jäger, Klaus-Heiko Wassill, Birgit Lorenz
PURPOSE: CLN3 is a rare lysosomal storage disorder. The majority of the patients suffer from neurological degeneration in the first decade of life leading to death in the second or third decade. One of the first symptoms is a rapid visual decline from retinal degeneration. The aim of this study was to correlate the retinal changes in CLN3 as seen with spectral domain optical coherence tomography (SD-OCT) with functional data in patients in the first years after the subjective onset of ocular symptoms...
August 2, 2016: Ophthalmic Genetics
https://www.readbyqxmd.com/read/27378278/the-effect-of-cilostazol-on-electrophysiologic-changes-in-non-proliferative-diabetic-retinopathy-patients
#20
Hoon Dong Kim, Si Hyoung Lee, Yoon Kyoung Kim, Jong Rok Oh, Young-Hoon Ohn
PURPOSE: To evaluate the effects of cilostazol, an antiplatelet and vasodilation agent, on the retinal function of patients with non-proliferative diabetic retinopathy (NPDR) using a full-field electroretinogram (ffERG). METHODS: A total of 20 eyes from 20 patients were enrolled as the cilostazol-treated group, and 16 eyes from 16 patients were enrolled as the control group to assess the functional effects of cilostazol. Ophthalmologic examinations including fundus fluorescein angiography (FFA), fundus color photography, optical coherence tomography (OCT), and ffERG responses were recorded at baseline and after 1 year of cilostazol treatment...
August 2016: Documenta Ophthalmologica. Advances in Ophthalmology
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