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Ophthalmology photography

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https://www.readbyqxmd.com/read/29661534/a-new-chlorin-formulation-promotes-efficient-photodynamic-action-in-choriocapillaris-of-rabbit-s-eyes
#1
Gustavo H A Salomao, Adjaci U Fernandes, Mauricio S Baptista, João Paulo Tardivo, Stella Gianssante, Juliana Mora Veridiano, Olga Maria S Toledo, Giuliana Petri, Denise Maria Christofolini, João Antonio Correa
Age-related macular degeneration (AMD) as well as other choroidal diseases, demand novel therapeutic methods. Photodynamic therapy (PDT), which uses light and photosensitizer (PS) to cause specific vascular occlusion in the macula, is an interesting alternative. The only drug approved for the PDT treatment of AMD (Verteporfin) has a natural tendency to aggregate, demanding an expensive separation procedure during purification. We report a novel and affordable PS that is intrinsically protected against aggregation, the Monomeric Chlorin at High Concentration (MCHC-Chlorin), whose liposomal formulation was developed to provoke effective photodynamic action on the choroidal vasculature...
April 4, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29655617/novel-treatment-of-papillomatous-conjunctival-lesions-using-pattern-scanning-laser-photocoagulation-1-year-results
#2
R N Belfort, J Isenberg, A G Castillejos, R Sant'ana, A O Romano
PURPOSE: To evaluate the safety and 1-year effect of pattern scanning laser photocoagulation treatment for pedunculated papillomatous and sessile conjunctival lesions in a low-resource setting with extremely limited operating room access. METHODS: Adult patients with clinical diagnosis of conjunctival papilloma underwent complete ophthalmologic exam including anterior segment photography. After topical anesthesia and toluidine blue 1% instillation, the lesion was treated by pattern scanning photocoagulation using a duration time that varied from 20 to 100 ms and power from 600 to 1800 mW, treating the entire lesion surface with a 2 mm margin...
April 12, 2018: Ocular Surface
https://www.readbyqxmd.com/read/29580111/the-african-american-eye-disease-study-design-and-methods
#3
Roberta McKean-Cowdin, Alicia Fairbrother-Crisp, Mina Torres, Carlos Lastra, Farzana Choudhury, Xuejuan Jiang, Bruce Burkemper, Rohit Varma
PURPOSE: To describe the study design, operational and recruitment strategies, procedures, and baseline characteristics of the African American Eye Disease Study (AFEDS), a population-based assement of the prevalence of visual impairment, ocular disease, visual function, and health-related quality of life in African Americans. METHODS: This population-based, cross-sectional study included over 6000 African Americans 40 years and older residing in and around Inglewood, California...
March 26, 2018: Ophthalmic Epidemiology
https://www.readbyqxmd.com/read/29576900/three-cases-of-congenital-retinal-macrovessel-one-coexisting-with-cilioretinal-artery
#4
Bayram Gülpamuk, Pınar Kaya, Mehmet Yasin Teke
In this report, we describe three cases of retinal macrovessel. Two of the three patients presented to our clinic for annual eye exam and had no visual complaints. The third patient presented because of vision loss in the left eye. Two patients had 20/20 best corrected visual acuity in both eyes and the third patient had 20/20 in the right eye, 20/25 in the left eye. Pupillary exams were normal. Slit-lamp examinations of the anterior segment were unremarkable. Fundus examination revealed macrovessels in the left eyes of two patients and in the right eye of one patient...
February 2018: Turkish Journal of Ophthalmology
https://www.readbyqxmd.com/read/29549426/prevalence-of-choroidal-nevus-and-retinal-pigment-epithelial-alterations-in-vitiligo-patients
#5
Efrat Fleissig, Mor Pavlovksy, Anat Loewenstein, Dinah Zur, Hadas Newman, Shay Keren, Dafna Goldenberg, Efrat Bar-Ilan, Michaella Goldstein
PURPOSE: To investigate ocular manifestations in patients with vitiligo by multimodal imaging, including optical coherence tomography (OCT), color fundus photography, and fundus autofluorescence (FAF). METHODS: In this prospective, observational clinical study, vitiligo patients underwent ophthalmologic and dermatologic clinical assessment and imaging by spectral-domain OCT, FAF, and color fundus imaging. Ocular echography was performed as indicated. Statistical analysis was performed using paired T test and Pearson correlation...
March 16, 2018: Graefe's Archive for Clinical and Experimental Ophthalmology
https://www.readbyqxmd.com/read/29510401/subclinical-macular-edema-as-a-predictor-of-progression-to-central-involved-macular-edema-in-type-2-diabetes
#6
Conceição Lobo, Isabel Pires, Dalila Alves, Rajeev Pappuru, Luísa Ribeiro, José Cunha-Vaz
PURPOSE: The aim of this study was to examine the relationship between subclinical diabetic macular edema (SCME) and the development of central-involved macular edema (CIME) in patients with diabetes mellitus type-2 and mild nonproliferative diabetic retinopathy (NPDR), from 2 populations of different ethnicities. METHODS: Two hundred and five patients with diabetes mellitus type-2 and mild NPDR with no prior laser or intravitreal treatment were followed for 2 years or until the development of CIME...
March 6, 2018: Ophthalmic Research
https://www.readbyqxmd.com/read/29444552/optometry-facilitated-teleophthalmology-an-audit-of-the-first-year-in-western-australia
#7
Stephen E Bartnik, Stephen P Copeland, Angela J Aicken, Angus W Turner
BACKGROUND: Lions Outback Vision has run a state-wide teleophthalmology service since 2011. In September 2015 the Australian federal government introduced a Medicare reimbursement for optometry-facilitated teleophthalmology consultations under specific circumstances. This audit demonstrates the first 12 months experience with this scheme. We aim to provide practical insights for others looking to embed a telemedicine program as part of delivering outreach clinical services. METHODS: A 12-month retrospective audit was performed between September 2015 and August 2016, inclusive...
February 14, 2018: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29429256/-prevalence-and-risk-factors-of-diabetic-retinopathy-in-hospital-patients
#8
Y Zhang, M Niu, Y Li, J Wang, B Qu, C X Zheng, P Huang, W H Yu
Objective: To analyze the prevalence and risk factors of diabetic retinopathy (DR) in ophthalmic patients. Methods: A cross-sectional study was performed. Diabetic patients who were admitted to Department of Ophthalmology, Traditional Chinese Medicine Hospital of Muping between October 2012 and June 2013 were included. General information and medical history were obtained from each subject by questionaires. Laboratory and detailed ophthalmic examinations were performed during the study. DR was diagnosed and graded by mydriatic fundus photography...
February 6, 2018: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/29338133/pimasertib-associated-ophthalmological-adverse-events
#9
Elon H C van Dijk, Wim H J Kruit, Martine J Jager, Gregorius P M Luyten, Johannes R Vingerling, Camiel J F Boon
PURPOSE: To analyse ophthalmological adverse events associated with mitogen-activated protein kinase kinase (MEK) inhibition with pimasertib treatment for metastatic cutaneous melanoma (CM). METHODS: In this prospective observational, cohort-based, cross-sectional study, eight patients treated with the MEK inhibitor pimasertib received a complete ophthalmic examination. This included Early Treatment of Diabetic Retinopathy Study best-corrected visual acuity, visual field testing, colour vision testing, slit-lamp examination, applanation tonometry, indirect ophthalmoscopy, digital colour fundus photography and optical coherence tomography (OCT)...
January 16, 2018: Acta Ophthalmologica
https://www.readbyqxmd.com/read/29332119/autofluorescence-of-skin-advanced-glycation-end-products-as-a-risk-factor-for-open-angle-glaucoma-the-alienor-study
#10
Cedric Schweitzer, Audrey Cougnard-Gregoire, Vincent Rigalleau, Jean-Francois Dartigues, Florence Malet, Marie-Benedicte Rougier, Marie-Noelle Delyfer, Catherine Helmer, Jean-Francois Korobelnik, Cecile Delcourt
Purpose: To analyze the association between skin autofluorescence (sAF), estimating tissue accumulation of advanced glycation end-products (AGEs), and open angle glaucoma (OAG) in an elderly population. Methods: The Antioxydants, Lipides Essentiels, Nutrition and maladies OculaiRes (ALIENOR) study is an on-going epidemiologic population-based study on age-related eye diseases. In 2009 to 2010, 624 subjects, aged 74 years or older, were recruited. All subjects underwent a complete eye examination, including optic disc color photography and spectral-domain optical coherence tomography (SD-OCT) examination...
January 1, 2018: Investigative Ophthalmology & Visual Science
https://www.readbyqxmd.com/read/29304264/propranolol-for-proliferative-diabetic-retinopathy
#11
Andrew M Hendrick, Jeremy A Lavine, Amitha Domalpally, Amol D Kulkarni, Michael S Ip
BACKGROUND AND OBJECTIVE: To determine the effect of propranolol on retinal neovascularization due to proliferative diabetic retinopathy (PDR). PATIENTS AND METHODS: For this prospective pilot, interventional, case series, patients with diabetes with PDR (n = 10 subjects; 12 eyes) were recruited at the ophthalmology clinic of the University of Wisconsin - Madison. Subjects were administered oral propranolol for 12 weeks and retinopathy and area of retinal neovascularization were monitored with fundus photography and fluorescein angiography (FA)...
January 1, 2018: Ophthalmic Surgery, Lasers & Imaging Retina
https://www.readbyqxmd.com/read/29303881/association-between-optic-disc-hemorrhage-and-renal-function-in-south-korea
#12
Jae Yeun Lee, Joon Mo Kim, Seong Hee Shim, Jin Young Lee, Chungkwon Yoo, Yu Sam Won, Young Youl Hyun, Ki Ho Park
PURPOSE: The purpose of this article is to investigate the relationship between renal function and disc hemorrhage (DH). MATERIALS AND METHODS: This retrospective cross-sectional survey was conducted at Kangbuk Samsung Hospital Health Screening Center between August 2012 and July 2013, and a total of 168,044 participants at least 20 years of age who voluntarily visited the health screening center for systemic and ophthalmologic examinations, including fundus photography, were enrolled...
March 2018: Journal of Glaucoma
https://www.readbyqxmd.com/read/29276052/nonsyndromic-retinitis-pigmentosa-in-the-ashkenazi-jewish-population-genetic-and-clinical-aspects
#13
Adva Kimchi, Samer Khateb, Rong Wen, Ziqiang Guan, Alexey Obolensky, Avigail Beryozkin, Shoshi Kurtzman, Anat Blumenfeld, Eran Pras, Samuel G Jacobson, Tamar Ben-Yosef, Hadas Newman, Dror Sharon, Eyal Banin
PURPOSE: To analyze the genetic and clinical findings in retinitis pigmentosa (RP) patients of Ashkenazi Jewish (AJ) descent, aiming to identify genotype-phenotype correlations. DESIGN: Cohort study. PARTICIPANTS: Retinitis pigmentosa patients from 230 families of AJ origin. METHODS: Sanger sequencing was performed to detect specific founder mutations known to be prevalent in the AJ population. Ophthalmologic analysis included a comprehensive clinical examination, visual acuity (VA), visual fields, electroretinography, color vision testing, and retinal imaging by OCT, pseudocolor, and autofluorescence fundus photography...
December 22, 2017: Ophthalmology
https://www.readbyqxmd.com/read/29199884/congenital-cavitary-optic-disc-anomaly-and-axenfeld-s-anomaly-in-wolf-hirschhorn-syndrome-a-case-report-and-review-of-the-literature
#14
Mohsin H Ali, Nathalie F Azar, Vinay Aakalu, Felix Y Chau, Javaneh Abbasian, Pete Setabutr, Irene H Maumenee
BACKGROUND: Wolf-Hirschhorn syndrome is a rare genetic syndrome caused by a heterozygous deletion on chromosome 4p16.3 and is characterized by a "Greek warrior helmet" facies, hypotonia, developmental delay, seizures, structural central nervous system defects, intrauterine growth restriction, sketelal anomalies, cardiac defects, abnormal tooth development, and hearing loss. A variety of ocular manifestations may occur in up to 40% of patients. MATERIALS/METHODS: We report the genetic testing results, systemic findings, and complete ophthalmologic examination findings in a patient with Wolf-Hirschhorn syndrome, including external photography, RetCam3 (Clarity Medical Systems, Pleasonton, CA) goniography, and fundus photography...
April 2018: Ophthalmic Genetics
https://www.readbyqxmd.com/read/29190234/familial-central-serous-chorioretinopathy
#15
Elon H C van Dijk, Rosa L Schellevis, Myrte B Breukink, Danial Mohabati, Greet Dijkman, Jan E E Keunen, Suzanne Yzer, Anneke I den Hollander, Carel B Hoyng, Eiko K de Jong, Camiel J F Boon
PURPOSE: To assess ophthalmologic characteristics in patients and unaffected individuals in families with multiple members affected by central serous chorioretinopathy (CSC), both at presentation and long-term follow-up. METHODS: In 103 subjects from 23 families with at least 2 affected patients with CSC per family, prospective extensive ophthalmologic examination was performed, including best-corrected visual acuity, indirect ophthalmoscopy, digital color fundus photography, optical coherence tomography, fundus autofluorescence, and fluorescein angiography imaging...
November 28, 2017: Retina
https://www.readbyqxmd.com/read/29134133/monitoring-and-morphologic-classification-of-pediatric-cataract-using-slit-lamp-adapted-photography
#16
Erping Long, Zhuoling Lin, Jingjing Chen, Zhenzhen Liu, Qianzhong Cao, Haotian Lin, Weirong Chen, Yizhi Liu
Purpose: To investigate the feasibility of pediatric cataract monitoring and morphologic classification using slit lamp-adapted anterior segmental photography in a large cohort that included uncooperative children. Methods: Patients registered in the Childhood Cataract Program of the Chinese Ministry of Health were prospectively selected. Eligible patients underwent slit-lamp adapted anterior segmental photography to record and monitor the morphology of their cataractous lenses...
November 2017: Translational Vision Science & Technology
https://www.readbyqxmd.com/read/29077180/large-choroidal-excavation-in-a-patient-with-rubella-retinopathy
#17
Maurizio Battaglia Parodi, Francesco Romano, Marco Montagna, Francesco Bandello
PURPOSE: To describe a case of rubella retinopathy complicated by bilateral choroidal neovascularization (CNV) and late development of large choroidal excavation (LCE). METHODS: A 19-year-old woman with a diagnosis of rubella retinopathy underwent her annual ophthalmologic examination, including visual acuity testing and slit-lamp biomicroscopy with dilated fundus examination. Color fundus photography, spectral-domain optical coherence tomography (SD-OCT) scans, and optical coherence tomography angiography were acquired to complete the investigation of her ocular condition...
October 17, 2017: European Journal of Ophthalmology
https://www.readbyqxmd.com/read/29074007/six-year-prevalence-and-incidence-of-diabetic-retinopathy-and-cost-effectiveness-of-tele-ophthalmology-in-manitoba
#18
Raageen Kanjee, Ravi I Dookeran, Mathen K Mathen, Frank A Stockl, Richard Leicht
OBJECTIVE: The purpose of this study was to evaluate the diabetic retinopathy (DR) tele-ophthalmology screening program in Manitoba to determine prevalence and incidence of DR, as well as to estimate the program's cost-effectiveness. DESIGN: Retrospective chart review. PARTICIPANTS: A total of 4676 patients with type 2 diabetes examined 9334 times from 2007 to 2013. METHODS: Focused ophthalmic histories were recorded and examinations were performed by trained nurses, including visual acuities, intraocular pressure, and mydriatic 7 standard field stereoscopic fundus photography...
November 2017: Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie
https://www.readbyqxmd.com/read/29050187/-cytokine-analysis-of-aqueous-humor-in-aids-patients
#19
W J Kong, C G Guo, L Y Xie, W B Wei, H W Dong, C Chen, K F Du
Objective: To explore the Cytokine of aqueous humor in AIDS patients with different eye diseases. Methods: A case-control study including 38 patients who was diagnosed as acquired immunodeficiency syndrome(AIDS) at Infectious Center and Department of Ophthalmology in Beijing You'an Hospital, Capital Medical University. And 16 cases of 38 patients were cytomegalovirus retinitis (CMVR), 14 cases were HIV-related retinal disease, and 8 cases presented as normal. A series of tests were performed including vision acuity check, intraocular pressure, fundus photography, blood cell count of CD4+ T lymphocyte and the content of cytokines in aqueous humor by Luminex 200(TM) liquid chip analyzer...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/29027884/accuracy-and-reliability-of-a-handheld-nonmydriatic-fundus-camera-for-the-remote-detection-of-optic-disc-edema
#20
Lulu Bursztyn, Maria A Woodward, Wayne T Cornblath, Hilary M Grabe, Jonathan D Trobe, Leslie Niziol, Lindsey B De Lott
BACKGROUND: Optic disc edema can be an important indicator of serious neurological disease, but is poorly detected using the direct ophthalmoscope. Portable fundus photography may overcome this difficulty. INTRODUCTION: The purpose of this study was to determine the sensitivity and specificity of a handheld, nonmydriatic fundus camera for the detection of optic disc edema. MATERIALS AND METHODS: Retrospective review of nonmydriatic optic disc photographs taken with a portable fundus camera (Pictor Plus; Volk Optical, Mentor, OH) from the University of Michigan Neuro-Ophthalmology Clinics...
October 13, 2017: Telemedicine Journal and E-health: the Official Journal of the American Telemedicine Association
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