Shannon J Ho, Dale Chaput, Rachel G Sinkey, Amanda H Garces, Erika P New, Maja Okuka, Peng Sang, Sefa Arlier, Nihan Semerci, Thora S Steffensen, Thomas J Rutherford, Angel E Alsina, Jianfeng Cai, Matthew L Anderson, Ronald R Magness, Vladimir N Uversky, Derek A T Cummings, John C M Tsibris
VEGFR2 (Vascular endothelial growth factor receptor 2) is a central regulator of placental angiogenesis. The study of the VEGFR2 proteome of chorionic villi at term revealed its partners MDMX (Double minute 4 protein) and PICALM (Phosphatidylinositol-binding clathrin assembly protein). Subsequently, the oxytocin receptor (OT-R) and vasopressin V1aR receptor were detected in MDMX and PICALM immunoprecipitations. Immunogold electron microscopy showed VEGFR2 on endothelial cell (EC) nuclei, mitochondria, and Hofbauer cells (HC), tissue-resident macrophages of the placenta...
April 9, 2024: Cell Communication and Signaling: CCS