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Parathyroid surgery

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https://www.readbyqxmd.com/read/28426880/surgeon-volume-in-parathyroid-surgery-surgical-efficiency-outcomes-and-utilization
#1
Charles Meltzer, Marc Klau, Deepak Gurushanthaiah, Joanne Tsai, Di Meng, Linda Radler, Alvina Sundang
No abstract text is available yet for this article.
April 20, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28422848/teriparatide-as-a-nonoperative-treatment-for-tibial-and-femoral-fracture-nonunion-a-case-report
#2
Li Xiaofeng, Xu Daxia, Chen Yunzhen
RATIONALE: Fracture nonunion is a great challenge for orthopedic surgeons. Many surgical interventions are associated with significant pain and heavy economic burden. Therefore, our aim was to evaluate the outcomes of a new nonoperative treatment for fracture nonunion. PATIENT CONCERNS: A 44-year-old man suffered closed fractures of the right tibia and left femur. Eleven months after surgery, there was no radiographic healing between fracture fragments. DIAGNOSES: Fracture nonunion of the right tibia and left femur...
April 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28409372/primary-hyperparathyroidism-treated-by-transoral-endoscopic-parathyroidectomy-vestibular-approach-toepva
#3
Thanyawat Sasanakietkul, Tobias Carling
BACKGROUND: Bilateral open cervical exploration with identifying all parathyroid glands and removing one or more enlarged parathyroid tumor(s) was the standard of care in primary hyperparathyroidism (pHPT). With the introduction of preoperative imaging and intraoperative parathyroid hormone (IOPTH) measurements [1, 2], various minimally invasive parathyroidectomy approaches have been developed, both open and endoscopic [3-8]. The most commonly used approach currently in the USA is the minimally invasive open parathyroidectomy (MIP), which can be performed in the ambulatory setting with excellent cure and minimal complication rates [9-12]...
April 13, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28399538/risk-factors-for-intraoperative-hypertension-during-the-surgery-of-primary-hyperparathyroidism
#4
Vera D Sabljak, Vladan R Zivaljevic, Biljana R Milicic, Ivan R Paunovic, Anka R Toskovic, Ksenija S Stevanovic, Katarina M Tausanovic, Dejan Z Markovic, Marina M Stojanovic, Mirko V Lakicevic, Milan D Jovanovic, Aleksandar D Diklic, Nevena K Kalezic
OBJECTIVE: To investigate the incidence and to identify risk factors for the occurrence of intraoperative hypertension (IOH) during the surgery of primary hyperparathyroidism (pHPT). SUBJECTS AND METHODS: The study included 269 patients surgically treated between January 2008 and January 2012 for pHPT. The IOH was defined as an increase in systolic blood pressure ≥ 20% compared to baseline values which lasted for 15 minutes. The investigated influence were demographic characteristics, surgical risk score related to physical status (based on American Society of Anesthesiologists - ASA classification), comorbidities, type and duration of surgery and duration of anesthesia on IOH occurrence...
April 10, 2017: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
https://www.readbyqxmd.com/read/28398918/histological-features-of-methylene-blue-induced-phototoxicity-administered-in-the-context-of-parathyroid-surgery
#5
Ciara A Maguire, Anup Sharma, Lida Alarcon, Lorrette Ffolkes, Malgorzata Kurzepa, Lucy Ostlere, Venura Samarasinghe, Manuraj Singh
Methylene blue is a chromophore dye known for its photosensitizing properties. It is also administered intravenously as a tracer in parathyroid surgery to identify abnormal glands. We describe 2 cases of acute methylene blue-induced phototoxicity in patients who underwent parathyroidectomy. Both patients developed an acute vesiculopustular inflammatory rash on the anterior neck corresponding to the site exposed intraoperatively to overhanging surgical lights. One of the patients also developed a bulla on her finger at the site of attachment of the oxygen probe...
March 16, 2017: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/28394026/recurrent-hyperparathyroidism-due-to-a-novel-cdc73-splice-mutation
#6
Namita Ganesh Hattangady, Tremika Le-Shan Wilson, Barbra Sue Miller, Antonio Marcondes Lerario, Thomas James Giordano, Palak Choksi, Tobias Else
CONTEXT: The recognition of hereditary causes of primary hyperparathyroidism (pHPT) is important as clinical care and surveillance differ significantly between sporadic and hereditary pHPT. In addition, the increasing number of genetic tests poses a challenge to classify mutations as benign or pathogenic. Functional work-up of variants remains a mainstay to provide evidence for pathogenicity. CASE DESCRIPTION: We describe a 52-year old male patient with recurrent pHPT since age 35...
April 10, 2017: Journal of Bone and Mineral Research: the Official Journal of the American Society for Bone and Mineral Research
https://www.readbyqxmd.com/read/28384917/delayed-post-surgical-hypoparathyroidism-the-forgotten-chameleon
#7
Sangita Deepak Kamath, Balllamudi Srinivas Rao
Delayed hypoparathyroidism, due to accidental gland removal or ischemia of parathyroids can present many years after thyroidectomy and symptoms may be non-specific. This condition, if not diagnosed timely, may prove fatal and have serious consequences. Hence, clinicians must have a high index of suspicion to treat this condition. All patients with a history of previous thyroid surgery, who come with vague symptoms like fatigue, muscle aches should undergo estimation of serum calcium, phosphorus and Parathyroid Hormone (PTH) due to the lack of any pathognomonic features of hypoparathyroidism...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28383779/factors-influencing-preoperative-urinary-calcium-excretion-in-primary-hyperparathyroidism
#8
Reto Martin Kaderli, Philipp Riss, Angelika Geroldinger, Andreas Selberherr, Christian Scheuba, Bruno Niederle
OBJECTIVE: Normal or elevated 24-hour urinary calcium (Ca) excretion is a diagnostic marker in primary hyperparathyroidism (PHPT). It is used to distinguish familial hypocalciuric hypercalcaemia (FHH) from PHPT by calculating the Ca/creatinine clearance ratio (CCCR). The variance of CCCR in patients with PHPT is considerable. The aim of the present study was to analyse the parameters affecting CCCR in patients with PHPT. DESIGN: The data were collected prospectively...
April 6, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28375869/hungry-bone-syndrome
#9
Nishank Jain, Robert F Reilly
PURPOSE OF REVIEW: In the United States, the number of parathyroidectomies among patients with chronic dialysis has remained stable in the last decade. A fall in serum calcium concentration is common postparathyroidectomy in patients with hyperparathyroidism, which usually resolves in 2-4 days. A severe drop in serum total calcium concentration less than 2.1 mmol/L and/or prolonged hypocalcemia for more than 4 days postparathyroidectomy is called hungry bone syndrome (HBS). Concomitant hypophosphatemia, hypomagnesemia, and hyperkalemia can be seen...
April 1, 2017: Current Opinion in Nephrology and Hypertension
https://www.readbyqxmd.com/read/28374221/less-is-more-time-to-expand-the-indications-for-minimally-invasive-video-assisted-parathyroidectomy
#10
S Bakkar, V Matteucci, C Corsini, S Pagliaro, P Miccoli
PURPOSE: Minimally invasive video-assisted parathyroidectomy (MIVAP) is one of the most widespread targeted parathyroid surgeries for primary hyperparathyroidism (PHP). The aim of this study was to assess its limits and propose an expansion of its indications in the management of parathyroid pathology. METHODS: A retrospective analysis of 77 consecutive patients who underwent MIVAP for PHP between Jan and Oct 2016 was conducted. The adequacy of the procedure and/or the need to convert to a standard cervicotomy was the main outcome of interest...
April 3, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28371486/identification-of-parathyroid-tissue-in-thyroid-fine-needle-aspiration-a-combined-approach-using-cytology-immunohistochemical-and-molecular-methods
#11
Robert P Domingo, Lorna L Ogden, Laura C Been, Giulia C Kennedy, S Thomas Traweek
OBJECTIVES: Parathyroid (PT) lesions can be difficult to recognize in thyroid fine needle aspirations (FNAs), and when not identified correctly, PT cells may be mistaken for potentially abnormal thyroid cells. We therefore studied the utility of combining cytology, immunohistochemistry, and a molecular classifier to identify PT cells in thyroid FNAs. METHODS: Thyroid FNAs were received in CytoLyt, and were evaluated initially using The Bethesda System for Reporting Thyroid Cytology (TBSRTC)...
March 30, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28370789/preoperative-vitamin-d-level-as-predictor-of-post-thyroidectomy-hypocalcemia-in-patients-sustaining-transient-parathyroid-injury
#12
Deepa Danan, David C Shonka
BACKGROUND: Several studies have sought to identify predictors of postoperative hypocalcemia after total thyroidectomy; however, there have been conflicting results regarding the impact of preoperative vitamin D deficiency. METHODS: The medical records of patients undergoing total thyroidectomy were retrospectively reviewed. The number of parathyroid glands identified or reimplanted at the time of surgery was used as a marker of transient parathyroid gland damage...
March 29, 2017: Head & Neck
https://www.readbyqxmd.com/read/28370683/management-of-unilateral-recurrent-laryngeal-nerve-injury-after-thyroid-surgery-a-review
#13
REVIEW
Jeremy Lynch, Rajeev Parameswaran
BACKGROUND: Recurrent laryngeal nerve (RLN) damage because of thyroid and parathyroid surgery has been recognized for over a century. Injury rates have been slowly decreasing in this period while effective treatment strategies have been increasing. METHODS: Recent literature was evaluated on the topics of anatomy, pathophysiology, avoidance, and conservative and surgical treatment of RLN injury. Data for this literature review were identified by PubMed and references from relevant articles using the search terms "thyroid," "laryngeal nerve," and "injury...
April 3, 2017: Head & Neck
https://www.readbyqxmd.com/read/28364157/increased-identification-of-parathyroid-glands-using-near-infrared-light-during-thyroid-and-parathyroid-surgery
#14
Jorge Falco, Fernando Dip, Pablo Quadri, Martin de la Fuente, Marcos Prunello, Raúl J Rosenthal
BACKGROUND: Parathyroid gland (PG) identification during thyroid and parathyroid surgery is challenging. Accidental parathyroidectomy increases the rate of postoperative hypocalcaemia. Recently, autofluorescence with near infrared light (NIRL) has been described for PG visualization. The aim of this study is to analyze the increased rate of visualization of PGs with the use of NIRL compared to white light (WL). MATERIALS AND METHODS: All patients undergoing thyroid and parathyroid surgery were included in this study...
March 31, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28362393/two-techniques-to-create-hypoparathyroid-mice-parathyroidectomy-using-gfp-glands-and-diphtheria-toxin-mediated-parathyroid-ablation
#15
Ruiye Bi, Yi Fan, En Luo, Quan Yuan, Michael Mannstadt
Hypoparathyroidism (HP) is a disorder characterized by low levels of PTH which lead to hypocalcemia, hyperphosphatemia, and low bone turnover. The most common cause of the disease is accidental removal of the parathyroid glands during thyroid surgery. Novel therapies for HP are needed, but testing them requires reliable animal models of acquired HP. Here, we demonstrate the generation of two mouse models of acquired HP. In the GFP-PTX model, mice with green fluorescent protein (GFP) expressed specifically in the parathyroids (PTHcre-mTmG) were created by crossing PTHcre(+) mice with Rosa-mTmG(fl/fl) mice...
March 14, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28358958/association-of-parathyroid-gland-biopsy-excision-technique-with-ex-vivo-radiation-counts-during-radioguided-parathyroid-surgery
#16
Andrew M Hinson, Bradley R Lawson, Aime T Franco, Brendan C Stack
Importance: Parathyroid biopsy represents a means for normal and hyperfunctional glands to be distinguished intraoperatively. However, no data exist to guide surgeons regarding how much of a parathyroid gland must be biopsied to satisfy the 20% rule. Objective: To quantify the relative proportion of a hyperfunctional parathyroid gland that must be evaluated with the gamma probe to satisfy the 20% rule. Design, Setting, and Participants: A retrospective review of surgical data for 24 consecutive patients (16 women, 18 men; mean [SD] age, 66...
March 30, 2017: JAMA Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28350886/parathyroid-score-can-predict-the-duration-of-required-calcium-supplementation-after-total-thyroidectomy
#17
Bup-Woo Kim, Soo Young Kim, Yong Sang Lee, Seok-Mo Kim, Hang-Seok Chang, Cheong Soo Park
BACKGROUND: Postoperative hypoparathyroidism is the most common complication after total thyroidectomy, owing to unintentional injury or decreased blood flow to the parathyroid glands. Prediction of postoperative hypoparathyroidism would be helpful for surgeons to manage postoperative hypocalcemia. In this study, we scored the discoloration of the parathyroid glands using a new parathyroid scoring system and evaluated the correlation between the parathyroid score and duration of required calcium supplementation after total thyroidectomy...
2017: PloS One
https://www.readbyqxmd.com/read/28336832/-surgical-and-non-surgical-management-of-primary-hyperparathyroidism-how-do-calcimimetics-work
#18
Yasuhiro Takeuchi
Primary hyperparathyroidism is a common endocrine disease. The first line therapy for the disease is surgical removal of affected parathyroid gland(s). Other therapeutic options with medication are needed to be established, because many of patients with primary hyperparathyroidism have few or no symptoms and are expected to have a long life expectancy without surgery. Cinacalcet as a calcimimetic, bisphosphonates and denosumab are promising candidates for medical management of the disease. Effectiveness and efficiency of these drugs for patients with primary hyperparathyroidism is to be evaluated in comparison with surgical treatment...
2017: Clinical Calcium
https://www.readbyqxmd.com/read/28334546/-parathyroid-cancer
#19
Ivana Ságová, Matej Stančík, Peter Kentoš, Dušan Pavai, Daniela Kantárová, Anton Vaňuga, Peter Vaňuga
Parathyroid cancer is a rare endocrine malignancy, representing less than 1 % of all cases of primary hyperparathyroidism. The exact etiology of the disease remains unknown. Known risk factors include neck irradiation, end stage renal failure, genetic factors, particularly the the HPRT2/CDCT73 gene mutation. The clinical picture is often indolent, yet progressive with a trend of local invasion and metastasis formation in advanced disease. The clinical picture includes symptoms of severe and resistant hypercalcemia, requiring intensive therapy often with the need of dialysis...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28329921/neuroendocrine-tumors-in-the-stomach-duodenum-and-pancreas-accompanied-by-novel-men1-gene-mutation
#20
Min A Yang, Woong Ki Lee, Hong Shik Shin, Sung Hyun Park, Byung Sun Kim, Ji Woong Kim, Jin Woong Cho, So Hee Yun
Multiple endocrine neoplasia type 1 (MEN1) syndrome is a relatively rare disease, characterized by the occurrence of multiple endocrine tumors in the parathyroid and pituitary glands as well as the pancreas. Here, we report a case of MEN1 with neuroendocrine tumors (NETs) in the stomach, duodenum, and pancreas. A 53-year-old man visited our hospital to manage gastric NET. Five years prior to his visit, he had undergone surgery for incidental meningioma. His brother had pancreatic nodules and a history of surgery for adrenal adenoma...
March 25, 2017: Korean Journal of Gastroenterology, Taehan Sohwagi Hakhoe Chi
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