Judith Sommer, Hanna Ehnis, Tatjana Seitz, Julia Schneider, Andreas B Wild, Sandra Moceri, Christa Buechler, Aline Bozec, Georg F Weber, Susanne Merkel, Ruth Beckervordersandforth, Alexander Steinkasserer, Roland Schüle, Jonel Trebicka, Arndt Hartmann, Anja Bosserhoff, Stephan von Hörsten, Peter Dietrich, Claus Hellerbrand
Obesity is characterized by the expansion of the adipose tissue, usually accompanied by inflammation, with a prominent role of macrophages infiltrating the visceral adipose tissue (VAT). This chronic inflammation is a major driver of obesity-associated comorbidities. Four-and-a-half LIM-domain protein 2 (FHL2) is a multifunctional adaptor protein that is involved in the regulation of various biological functions and the maintenance of the homeostasis of different tissues. In this study, we aimed to gain new insights into the expression and functional role of FHL2 in VAT in diet-induced obesity...
October 6, 2023: International Journal of Molecular Sciences