keyword
https://read.qxmd.com/read/37834391/four-and-a-half-lim-domain-protein-2-fhl2-induces-neuropeptide-y-npy-in-macrophages-in-visceral-adipose-tissue-and-promotes-diet-induced-obesity
#21
JOURNAL ARTICLE
Judith Sommer, Hanna Ehnis, Tatjana Seitz, Julia Schneider, Andreas B Wild, Sandra Moceri, Christa Buechler, Aline Bozec, Georg F Weber, Susanne Merkel, Ruth Beckervordersandforth, Alexander Steinkasserer, Roland Schüle, Jonel Trebicka, Arndt Hartmann, Anja Bosserhoff, Stephan von Hörsten, Peter Dietrich, Claus Hellerbrand
Obesity is characterized by the expansion of the adipose tissue, usually accompanied by inflammation, with a prominent role of macrophages infiltrating the visceral adipose tissue (VAT). This chronic inflammation is a major driver of obesity-associated comorbidities. Four-and-a-half LIM-domain protein 2 (FHL2) is a multifunctional adaptor protein that is involved in the regulation of various biological functions and the maintenance of the homeostasis of different tissues. In this study, we aimed to gain new insights into the expression and functional role of FHL2 in VAT in diet-induced obesity...
October 6, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37783761/identifying-potential-biomarkers-of-idiopathic-pulmonary-fibrosis-through-machine-learning-analysis
#22
JOURNAL ARTICLE
Zenan Wu, Huan Chen, Shiwen Ke, Lisha Mo, Mingliang Qiu, Guoshuang Zhu, Wei Zhu, Liangji Liu
Idiopathic pulmonary fibrosis (IPF) is the most common and serious type of idiopathic interstitial pneumonia, characterized by chronic, progressive, and low survival rates, while unknown disease etiology. Until recently, patients with idiopathic pulmonary fibrosis have a poor prognosis, high mortality, and limited treatment options, due to the lack of effective early diagnostic and prognostic tools. Therefore, we aimed to identify biomarkers for idiopathic pulmonary fibrosis based on multiple machine-learning approaches and to evaluate the role of immune infiltration in the disease...
October 2, 2023: Scientific Reports
https://read.qxmd.com/read/37783021/development-of-an-epigenetic-age-predictor-for-costal-cartilage-with-a-simultaneous-somatic-tissue-differentiation-system
#23
JOURNAL ARTICLE
A Freire-Aradas, M Tomsia, D Piniewska-Róg, A Ambroa-Conde, M A Casares de Cal, A Pisarek, A Gómez-Tato, J Álvarez-Dios, E Pośpiech, W Parson, M Kayser, C Phillips, W Branicki
Age prediction from DNA has been a topic of interest in recent years due to the promising results obtained when using epigenetic markers. Since DNA methylation gradually changes across the individual's lifetime, prediction models have been developed accordingly for age estimation. The tissue-dependence for this biomarker usually necessitates the development of tissue-specific age prediction models, in this way, multiple models for age inference have been constructed for the most commonly encountered forensic tissues (blood, oral mucosa, semen)...
September 29, 2023: Forensic Science International. Genetics
https://read.qxmd.com/read/37713585/integrative-analysis-from-multi-center-studies-identifies-a-weighted-gene-co-expression-network-analysis-based-tregs-signature-in-ovarian-cancer
#24
JOURNAL ARTICLE
Yang Cao, Ying-Lei Liu, Xiao-Yan Lu, Hai-Li Kai, Yun Han, Yan-Li Zheng
Ovarian cancer (OC) is a malignancy associated with poor prognosis and has been linked to regulatory T cells (Tregs) in the immune microenvironment. Nevertheless, the association between Tregs-related genes (TRGs) and OC prognosis remains incompletely understood. The xCell algorithm was used to analyze Tregs scores across multiple cohorts. Weighted gene co-expression network analysis (WGCNA) was utilized to identify potential TRGs and molecular subtypes. Furthermore, we used nine machine learning algorithms to create risk models with prognostic indicators for patients...
September 15, 2023: Environmental Toxicology
https://read.qxmd.com/read/37708708/fhl2-regulates-microglia-m1-m2-polarization-after-spinal-cord-injury-via-parp14-depended-stat1-6-pathway
#25
JOURNAL ARTICLE
Aihua Xu, Yang Yang, Yang Shao, Manyu Jiang, Yongxin Sun, Bo Feng
Neuronal apoptosis and inflammation exacerbate the secondary injury after spinal cord injury (SCI). Four and a half domains 2 (FHL2) is a multifunctional scaffold protein with tissue- and cell-type specific effects on the regulation of inflammation, but its role in SCI remains unclear. The T10 mouse spinal cord contusion model was established, and the mice were immediately injected with lentiviruses carrying FHL2 shRNA after SCI. The results showed that FHL2 expression was increased following SCI, and then gradually decreased...
November 2023: International Immunopharmacology
https://read.qxmd.com/read/37598451/investigation-of-the-impact-of-biogeographic-ancestry-on-dna-methylation-based-age-predictions-comparing-a-middle-east-and-a-central-european-population
#26
JOURNAL ARTICLE
J Fleckhaus, P Bugert, N A M Al-Rashedi, M A Rothschild
DNA methylation based age prediction is a new method in the toolbox of forensic genetics. Typically, the method is applied in the course of police investigation e.g. to predict the age of an unknown person that has left a biological trace at a crime scene. The method can also be used to answer other forensic questions, for example to estimate the age of unknown human bodies in the course of the identification process. In the present study, we tested for a potential impact of biogeographic ancestry (BGA) on age predictions using five age dependent methylated CpG sites within the genetic regions of ELOVL2, MIR29B2CHG, FHL2, KLF14 and TRIM59...
August 3, 2023: Forensic Science International. Genetics
https://read.qxmd.com/read/37529485/identification-and-interaction-analysis-of-molecular-markers-in-pancreatic-ductal-adenocarcinoma-by-bioinformatics-and-next-generation-sequencing-data-analysis
#27
JOURNAL ARTICLE
Muttanagouda Giriyappagoudar, Basavaraj Vastrad, Rajeshwari Horakeri, Chanabasayya Vastrad
BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) is one of the most common cancers worldwide. Intense efforts have been made to elucidate the molecular pathogenesis, but the molecular mechanisms of PDAC are still not well understood. The purpose of this study is to further explore the molecular mechanism of PDAC through integrated bioinformatics analysis. METHODS: To identify the candidate genes in the carcinogenesis and progression of PDAC, next-generation sequencing (NGS) data set GSE133684 was downloaded from Gene Expression Omnibus (GEO) database...
2023: Bioinformatics and Biology Insights
https://read.qxmd.com/read/37434686/comprehensive-pan-cancer-analysis-identifies-fhl2-associated-with-poor-prognosis-in-lung-adenocarcinoma
#28
JOURNAL ARTICLE
Bin Pan, Li Wan, Yu Li, Jian Yang, Zhike Chen, Xin Tong, Jun Zhao, Chang Li
BACKGROUND: The FHL family (four-and-a-half-LIM-only protein family) contains five multifunctional proteins (FHL1-5) that are involved in cell survival, transcriptional regulation, and signal transduction. Among these proteins, FHL2 is one of the most reported members in tumors, which is differentially expressed in numerous tumors. However, no systematic pan-cancer analysis of FHL2 has been performed so far. METHODS: We obtained The Cancer Genome Atlas (TCGA) expression profiles and clinical data from Xena database and the Tumor Immune Estimation Resource (TIMER) database...
June 30, 2023: Translational Cancer Research
https://read.qxmd.com/read/37365821/first-case-of-very-late-onset-fhl2-in-spain-with-two-variants-in-the-prf1-gene
#29
JOURNAL ARTICLE
Paula Sienes Bailo, Nuria Goñi Ros, Bárbara Menéndez Jándula, Ramiro Álvarez Alegret, Eduardo González Gómez, Ricardo González Tarancón, Silvia Izquierdo Álvarez
Hemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by mutations in genes encoding proteins involved in the granule-dependent cytotoxic pathway (familial hemophagocytic lymphohistiocytosis [FHL] types 1-5); and other secondary or acquired form, generally associated with infections, malignancy, autoimmune diseases, metabolic disorders or primary immunodeficiencies...
June 26, 2023: Annals of Clinical Biochemistry
https://read.qxmd.com/read/37323662/integrated-analysis-of-circrna-associated-cerna-network-in-ischemic-stroke
#30
JOURNAL ARTICLE
Rongli Fan, Die Hu, Maiqiu Wang, Huilin Zheng, Yifeng Zhou, Lei Zhang
Introduction: Stroke, of which ischemic stroke (IS) is the major type, is the second leading cause of disability and death worldwide. Circular RNAs (circRNAs) are reported to play important role in the physiology and pathology of IS. CircRNAs often act as competing endogenous RNA (ceRNA) to regulate gene expression by acting as miRNA sponges. However, whole transcriptome-wide screenings of circRNA-mediated ceRNA networks associated with IS are still lacking. In the present study, we constructed a circRNA-miRNA-mRNA ceRNA network by whole transcriptome-wide analysis...
2023: Frontiers in Genetics
https://read.qxmd.com/read/37175670/molecular-mechanisms-underlying-the-progression-of-aortic-valve-stenosis-bioinformatic-analysis-of-signal-pathways-and-hub-genes
#31
JOURNAL ARTICLE
Taiki Tojo, Minako Yamaoka-Tojo
The calcification of the aortic valve causes increased leaflet stiffness and leads to the development and progression of stenotic aortic valve disease. However, the molecular and cellular mechanisms underlying stenotic calcification remain poorly understood. Herein, we examined the gene expression associated with valve calcification and the progression of calcific aortic valve stenosis. We downloaded two publicly available gene expression profiles (GSE83453 and GSE51472) from NCBI-Gene Expression Omnibus database for the combined analysis of samples from human aortic stenosis and normal aortic valve tissue...
April 27, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/37121966/glia-maturation-factor-beta-deficiency-protects-against-diabetic-osteoporosis-by-suppressing-osteoclast-hyperactivity
#32
JOURNAL ARTICLE
Si Shi, Huijie Gu, Jinyuan Xu, Wan Sun, Caiyin Liu, Tong Zhu, Juan Wang, Furong Gao, Jieping Zhang, Qingjian Ou, Caixia Jin, Jingying Xu, Hao Chen, Jiao Li, Guotong Xu, Haibin Tian, Lixia Lu
Excessive osteoclast activation, which depends on dramatic changes in actin dynamics, causes osteoporosis (OP). The molecular mechanism of osteoclast activation in OP related to type 1 diabetes (T1D) remains unclear. Glia maturation factor beta (GMFB) is considered a growth and differentiation factor for both glia and neurons. Here, we demonstrated that Gmfb deficiency effectively ameliorated the phenotype of T1D-OP in rats by inhibiting osteoclast hyperactivity. In vitro assays showed that GMFB participated in osteoclast activation rather than proliferation...
May 1, 2023: Experimental & Molecular Medicine
https://read.qxmd.com/read/37103649/the-roles-of-fhl2-in-cancer
#33
REVIEW
Jiawei Zhang, Qun Zeng, Meihua She
LIM domain protein 2, also known as LIM protein FHL2, is a member of the LIM-only family. Due to its LIM domain protein characteristics, FHL2 is capable of interacting with various proteins and plays a crucial role in regulating gene expression, cell growth, and signal transduction in muscle and cardiac tissue. In recent years, mounting evidence has indicated that the FHLs protein family is closely associated with the development and occurrence of human tumors. On the one hand, FHL2 acts as a tumor suppressor by down-regulating in tumor tissue and effectively inhibiting tumor development by limiting cell proliferation...
April 27, 2023: Clinical and Experimental Medicine
https://read.qxmd.com/read/37065787/hbxip-knockdown-inhibits-fhl2-to-promote-cycle-arrest-and-suppress-cervical-cancer-cell-proliferation-invasion-and-migration
#34
JOURNAL ARTICLE
Xia Gao, Lina Yang
Hepatitis B X-interacting protein (HBXIP) and four and a half LIM domain 2 (FHL2) have been reported to serve as independent biomarkers for cervical cancer. The present study evaluated the effects of HBXIP on cervical cancer in terms of its cellular malignant characteristics. Reverse transcription-quantitative PCR and western blotting were used to assess the mRNA and protein expression levels of HBXIP and FHL2 in the human endocervical epithelial End1/E6E7 cell line and the cervical cancer HeLa, CaSki, C33A and SiHa cell lines...
May 2023: Oncology Letters
https://read.qxmd.com/read/37059707/correction-tab182-aggravates-progression-of-esophageal-squamous-cell-carcinoma-by-enhancing-%C3%AE-catenin-nuclear-translocation-through-fhl2-dependent-manner
#35
Aidi Gao, Zhenzi Su, Zengfu Shang, Chao He, Dongliu Miao, Xiaoqing Li, Shitao Zou, Weiqun Ding, Yue Zhou, Ming Sun, Jundong Zhou
No abstract text is available yet for this article.
April 14, 2023: Cell Death & Disease
https://read.qxmd.com/read/37015904/fhl2-deficiency-impairs-follicular-development-and-fertility-by-attenuating-egf-egfr-yap-signaling-in-ovarian-granulosa-cells
#36
JOURNAL ARTICLE
Chen Wang, Hui Sun, John S Davis, Xiaojie Wang, Lijun Huo, Nan Sun, Qianzhi Huang, Xiangmin Lv, Cheng Wang, Chunbo He, Changjiu He, Yang Zhou, Jiyun Wu, Liguo Yang, Guohua Hua
Female subfertility is an increasing reproductive issue worldwide, which is partially related to abnormal ovarian follicular development. Granulosa cells (GCs), by providing the necessary physical support and microenvironment for follicular development, play critical roles in maintaining female fertility. We previously showed that ectopic expression of four and a half LIM domains 2 (FHL2) promoted ovarian granulosa cell tumor progression. However, its function in follicular development and fertility remains unknown...
April 5, 2023: Cell Death & Disease
https://read.qxmd.com/read/36991505/distinguishable-dna-methylation-defines-a-cardiac-specific-epigenetic-clock
#37
JOURNAL ARTICLE
A Mongelli, S Panunzi, M Nesta, M Gottardi Zamperla, S Atlante, V Barbi, V Mongiardini, F Ferraro, S De Martino, L Cis, A Re, S Maltese, T Bachetti, M T La Rovere, F Martelli, M Pesce, S Nanni, M Massetti, A Pontecorvi, A Farsetti, C Gaetano
BACKGROUND: The present study investigates whether epigenetic differences emerge in the heart of patients undergoing cardiac surgery for an aortic valvular replacement (AVR) or coronary artery bypass graft (CABG). An algorithm is also established to determine how the pathophysiological condition might influence the human biological cardiac age. RESULTS: Blood samples and cardiac auricles were collected from patients who underwent cardiac procedures: 94 AVR and 289 CABG...
March 29, 2023: Clinical Epigenetics
https://read.qxmd.com/read/36982454/forensic-age-estimation-through-a-dna-methylation-based-age-prediction-model-in-the-italian-population-a-pilot-study
#38
JOURNAL ARTICLE
Martina Onofri, Arianna Delicati, Beatrice Marcante, Luigi Carlini, Federica Alessandrini, Pamela Tozzo, Eugenia Carnevali
DNA methylation is one of the epigenetic marks which has been studied intensively in recent years for age predicting purposes in the forensic area. In order to integrate age prediction into routine forensic workflow, the purpose of this study was to standardize and optimize a DNA methylation-based protocol tailored to the Italian context. A previously published protocol and age-predictive method was implemented for the analysis of 84 blood samples originating from Central Italy. The study here presented is based on the Single Base Extension method, considering five genes: ELOVL2, FHL2, KLF14, C1orf132, now identified as MIR29B2C, and TRIM59...
March 11, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36901761/fhl2-genetic-polymorphisms-and-pro-diabetogenic-lipid-profile-in-the-multiethnic-helius-cohort
#39
JOURNAL ARTICLE
Jayron J Habibe, Ulrika Boulund, Maria P Clemente-Olivo, Carlie J M de Vries, Etto C Eringa, Max Nieuwdorp, Bart Ferwerda, Koos Zwinderman, Bert-Jan H van den Born, Henrike Galenkamp, Daniel H van Raalte
Type 2 diabetes mellitus (T2D) is a prevalent disease often accompanied by the occurrence of dyslipidemia. Four and a half LIM domains 2 (FHL2) is a scaffolding protein, whose involvement in metabolic disease has recently been demonstrated. The association of human FHL2 with T2D and dyslipidemia in a multiethnic setting is unknown. Therefore, we used the large multiethnic Amsterdam-based Healthy Life in an Urban Setting (HELIUS) cohort to investigate FHL2 genetic loci and their potential role in T2D and dyslipidemia...
February 22, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36854411/-a-case-of-dilated-cardiomyopathy-caused-by-fhl2-gene-variant-and-a-literature-review
#40
JOURNAL ARTICLE
Chunrui Yu, Lijuan Jia, Chanjuan Hao, Bianjing Zuo, Wei Li, Fangjie Wang, Jun Guo
OBJECTIVE: To explore the clinical phenotype and genetic features of a child with dilated cardiomyopathy (DCM). METHODS: Clinical data of the child who had presented at the Zhengzhou Children's Hospital on April 28, 2020 was collected. Trio-whole exome sequencing (trio-WES) was carried out for the child and her parents, and candidate variants were validated by Sanger sequencing. "FHL2" was taken as the key word to retrieve related literature from January 1, 1997 to October 31, 2021 in the PubMed database and was also searched in the ClinVar database as a supplement to analyze the correlation between genetic variants and clinical features...
March 10, 2023: Zhonghua Yi Xue Yi Chuan Xue za Zhi, Zhonghua Yixue Yichuanxue Zazhi, Chinese Journal of Medical Genetics
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