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https://www.readbyqxmd.com/read/27873388/effects-of-sildenafil-on-cardiac-structure-and-function-cardiopulmonary-exercise-testing-and-health-related-quality-of-life-measures-in-heart-failure-patients-with-preserved-ejection-fraction-and-pulmonary-hypertension
#1
Licette C Y Liu, Yoran M Hummel, Peter van der Meer, Rolf M F Berger, Kevin Damman, Dirk J van Veldhuisen, Adriaan A Voors, Elke S Hoendermis
AIMS: We recently showed that sildenafil did not improve pulmonary pressures and exercise capacity in a cohort of patients with heart failure and preserved ejection fraction (HFpEF) and predominantly postcapillary pulmonary hypertension. Here, we present the effects of sildenafil on cardiac structure and function, cardiopulmonary exercise testing, laboratory parameters and health-related quality of life measures. METHODS AND RESULTS: Fifty-two HFpEF patients with pulmonary hypertension (mean pulmonary artery pressure >25 mmHg; pulmonary artery wedge pressure >15 mmHg) were randomized to sildenafil 60 mg three times a day or placebo and treated for 12 weeks...
November 21, 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27861471/-comparison-of-peak-oxygen-uptake-and-ve-vco2-slope-between-children-with-and-without-heart-failure
#2
Hermes Ilarraza-Lomelí, Irma Miranda Chávez, Javier Castañeda-López, Rafael Chávez-Domínguez, Carlos Felipe Barrera-Ramírez, Marianna García-Saldivia, María Dolores Rius-Suárez, Alfonso Buendía-Hernández
: Heart failure is a health problem associated with disability and mortality. Physicians may stratify the risk of adult patients with heart failure using a cardiopulmonary exercise testing. Until now, in childhood this evaluation has been poorly used. The purpose of this study is to compare the peak oxygen uptake and minute ventilation/carbon dioxide production slope among children with heart failure versus children without heart disease (control). METHODS: Thirty-eight children with heart failure were compared with 194 children without heart disease...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27812147/left-atrial-structure-and-function-in-heart-failure-with-preserved-ejection-fraction-a-relax-substudy
#3
Siddique A Abbasi, Ravi V Shah, Steven E McNulty, Adrian F Hernandez, Marc J Semigran, Gregory D Lewis, Michael Jerosch-Herold, Raymond J Kim, Margaret M Redfield, Raymond Y Kwong
Given the emerging recognition of left atrial structure and function as an important marker of disease in heart failure with preserved ejection fraction (HF-pEF), we investigated the association between left atrial volume and function with markers of disease severity and cardiac structure in HF-pEF. We studied 100 patients enrolled in the PhosphdiesteRasE-5 Inhibition to Improve CLinical Status and EXercise Capacity in Diastolic Heart Failure (RELAX) trial who underwent cardiac magnetic resonance (CMR), cardiopulmonary exercise testing, and blood collection before randomization...
2016: PloS One
https://www.readbyqxmd.com/read/27781371/acute-cardiorespiratory-responses-in-participants-with-heart-disease-during-cycling-at-different-immersion-levels
#4
Andrée Dionne, Louis Pérusse, Alain-Steve Comtois, Mario Leone
Physical activity is often avoided or practised at a low-intensity level because of the limited ability of patients with heart disease (HD) to provide sustained effort. Immersible training has been suggested as a possible alternative as hydrostatic pressure can modify some hemodynamic parameters in healthy patients and potentially increase the exercise capacity in patients with HD. The purpose of this study was to examine the acute cardiorespiratory adaptations at different levels of immersion using an immersible ergometer (IE) in patients with HD...
October 26, 2016: Clinical Physiology and Functional Imaging
https://www.readbyqxmd.com/read/27763583/altered-gas-exchange-at-peak-exercise-in-obese-adolescents-implications-for-verification-of-effort-during-cardiopulmonary-exercise-testing
#5
Nastasia Marinus, Liene Bervoets, Guy Massa, Kenneth Verboven, An Stevens, Tim Takken, Dominique Hansen
BACKGROUND: Cardiopulmonary exercise testing is advised ahead of exercise intervention in obese adolescents to assess medical safety of exercise and physical fitness. Optimal validity and reliability of test results are required to identify maximal exercise effort. As fat oxidation during exercise is disturbed in obese individuals, it remains an unresolved methodological issue whether the respiratory gas exchange ratio (RER) is a valid marker for maximal effort during exercise testing in this population...
October 20, 2016: Journal of Sports Medicine and Physical Fitness
https://www.readbyqxmd.com/read/27748473/exercise-training-in-heart-failure-patients-with-preserved-ejection-fraction-a-systematic-review-and-meta-analysis
#6
Erick Chan, Francesco Giallauria, Carlo Vigorito, Neil A Smart
Exercise training induces physical adaptations for heart failure patients with systolic dysfunction but less is known about those patients with preserved ejection fraction. This study's aims were to establish if exercise training produces changes in peak VO2 and related measures, quality of life, general health and diastolic function in heart failure patients with preserved ejection fraction (HFpEF). We conducted a MEDLINE search (1985 to September 1, 2015), for exercise based rehabilitation trials in heart failure, using search terms 'exercise training, heart failure with preserved ejection fraction, heart failure with  normal ejection fraction, peak VO2 and diastolic heart dysfunction'...
October 14, 2016: Monaldi Archives for Chest Disease, Archivio Monaldi Per le Malattie del Torace
https://www.readbyqxmd.com/read/27746738/the-physiological-mechanisms-of-performance-enhancement-with-sprint-interval-training-differ-between-the-upper-and-lower-extremities-in-humans
#7
Christoph Zinner, David Morales-Alamo, Niels Ørtenblad, Filip J Larsen, Tomas A Schiffer, Sarah J Willis, Miriam Gelabert-Rebato, Mario Perez-Valera, Robert Boushel, Jose A L Calbet, Hans-Christer Holmberg
To elucidate the mechanisms underlying the differences in adaptation of arm and leg muscles to sprint training, over a period of 11 days 16 untrained men performed six sessions of 4-6 × 30-s all-out sprints (SIT) with the legs and arms, separately, with a 1-h interval of recovery. Limb-specific VO2peak, sprint performance (two 30-s Wingate tests with 4-min recovery), muscle efficiency and time-trial performance (TT, 5-min all-out) were assessed and biopsies from the m. vastus lateralis and m. triceps brachii taken before and after training...
2016: Frontiers in Physiology
https://www.readbyqxmd.com/read/27746200/effect-of-balloon-pulmonary-angioplasty-on-respiratory-function-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#8
Mina Akizuki, Naoki Serizawa, Atsuko Ueno, Taku Adachi, Nobuhisa Hagiwara
RATIONALE: Balloon pulmonary angioplasty (BPA) in chronic thromboembolic pulmonary hypertension (CTEPH) improves hemodynamics and exercise capacity. However, its effect on respiratory function is unclear. OBJECTIVES: To investigate the effect of BPA on respiratory function. METHODS: We enrolled inoperable CTEPH who underwent BPA primarily in lower lobe arteries (first series) and upper and middle lobe arteries (second series). We compared changes in hemodynamics and respiratory function between different BPA fields...
October 13, 2016: Chest
https://www.readbyqxmd.com/read/27742182/discriminating-circulatory-problems-from-deconditioning-echocardiogram-and-cardio-pulmonary-exercise-test-analysis
#9
Zach Rozenbaum, Shafik Khoury, Galit Aviram, Yaniv Gura, Jack Sherez, Avi Man, Jason Shimiaie, Thierry Le Tourneau, Amir Halkin, Simon Biner, Gad Keren, Yan Topilsky
BACKGROUND: Discriminating circulatory problems with reduced stroke volume from de-conditioning in which the muscles cannot consume O2 normally by gas exchange parameters is difficult. METHODS: We performed combined stress echo and cardio-pulmonary (CPET) tests in 110 patients (20 normal effort capacity, 54 attenuated stroke volume response, 36 de-conditioning) to evaluate multiple hemodynamic parameters and oxygen content difference (A-VO2 Difference) in four predefined activity levels to assess which of the gas measures may help in the discrimination...
October 11, 2016: Chest
https://www.readbyqxmd.com/read/27730011/risk-stratification-in-lung-resection
#10
Michele Salati, Alessandro Brunelli
PURPOSE OF REVIEW: Surgery is considered the best treatment option for patients with early stage lung cancer. Nevertheless, lung resection may cause a variable functional impairment that could influence the whole cardio-respiratory system with potential life-threatening complications. The aim of the present study is to review the most relevant evidences about the evaluation of surgical risk before lung resection, in order to define a practical approach for the preoperative functional assessment in lung cancer patients...
2016: Current Surgery Reports
https://www.readbyqxmd.com/read/27692931/heart-failure-and-anemia-effects-on-prognostic-variables
#11
Gaia Cattadori, Piergiuseppe Agostoni, Ugo Corrà, Gianfranco Sinagra, Fabrizio Veglia, Elisabetta Salvioni, Alice Bonomi, Rocco La Gioia, Angela B Scardovi, Alessandro Ferraironi, Michele Emdin, Marco Metra, Andrea Di Lenarda, Giuseppe Limongelli, Rosa Raimondo, Federica Re, Marco Guazzi, Romualdo Belardinelli, Gianfranco Parati, Sergio Caravita, Damiano Magrì, Carlo Lombardi, Maria Frigerio, Fabrizio Oliva, Davide Girola, Alessandro Mezzani, Stefania Farina, Massimo Mapelli, Domenico Scrutinio, Giuseppe Pacileo, Anna Apostolo, AnnaMaria Iorio, Stefania Paolillo, Pasquale Perrone Filardi, Paola Gargiulo, Maurizio Bussotti, Giovanni Marchese, Michele Correale, Roberto Badagliacca, Susanna Sciomer, Pietro Palermo, Mauro Contini, Pantaleo Giannuzzi, Elisa Battaia, Mariantonietta Cicoira, Francesco Clemenza, Chiara Minà, Simone Binno, Claudio Passino, Massimo F Piepoli
BACKGROUND: Anemia is frequent in heart failure (HF), and it is associated with higher mortality. The predictive power of established HF prognostic parameters in anemic HF patients is unknown. METHODS: Clinical, laboratory, echocardiographic and cardiopulmonary-exercise-test (CPET) data were analyzed in 3913 HF patients grouped according to hemoglobin (Hb) values. 248 (6%), 857 (22%), 2160 (55%) and 648 (17%) patients had very low (<11g/dL), low (11-12 for females, 11-13 for males), normal (12-15 for females, 13-15 for males) and high (>15) Hb, respectively...
September 28, 2016: European Journal of Internal Medicine
https://www.readbyqxmd.com/read/27561166/prognostic-value-of-cardiopulmonary-exercise-testing-in-idiopathic-dilated-cardiomyopathy
#12
Gianfranco Sinagra, Annamaria Iorio, Marco Merlo, Antonio Cannatà, Davide Stolfo, Elena Zambon, Concetta Di Nora, Stefania Paolillo, Giulia Barbati, Emanuela Berton, Cosimo Carriere, Damiano Magrì, Gaia Cattadori, Marco Confalonieri, Andrea Di Lenarda, Piergiuseppe Agostoni
BACKGROUND: Although cardiopulmonary exercise testing (CPET) is considered as an important tool in risk stratification of patients with heart failure (HF), prognostic data in the specific setting of Idiopathic Dilated Cardiomyopathy (iDCM) are still undetermined. The aim of the study was to test the prognostic value of CPET in a large cohort of iDCM patients. METHODS AND RESULTS: We analyzed 381 iDCM patients who consecutively performed CPET. The study end-point was a composite of cardiovascular death/urgent heart transplantation (CVD/HTx)...
November 15, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27537719/exercise-related-ventilation-dynamics-and-clinical-correlates-in-patients-with-fibrotic-idiopathic-interstitial-pneumonias
#13
Marina De Martino, Raffaele Cobuccio, Dario Bruzzese, Gaetano Rea, Ilernando Meoli, Francesco Stefanelli, Angelo Canora, Annalisa Capaccio, Alessandro Sanduzzi, Alessandro Matarese, Marialuisa Bocchino
Assessment of exercise performance is a key component in the management of interstitial lung diseases, as its limitation may occur very early. Aim of the present study was to assess ventilation dynamics in combination with pulse-oximetry changes in 54 clinically stable patients affected by idiopathic pulmonary fibrosis or idiopathic fibrotic nonspecific interstitial pneumonia. Testing was successfully performed with the Spiropalm 6-MWT Hand-held spirometer by the majority of cases (94%). End test oxygen saturation (SpO2) values <88% were common in most of patients (76%), with a mean distance walked of 403 meters...
August 1, 2016: Sarcoidosis, Vasculitis, and Diffuse Lung Diseases: Official Journal of WASOG
https://www.readbyqxmd.com/read/27513650/the-effects-of-exercise-modality-on-maximal-and-submaximal-exercise-parameters-obtained-by-graded-maximal-exercise-testing
#14
Nils Cornelis, Roselien Buys
BACKGROUND: Cardiopulmonary exercise testing (CPET) has become part of screening and evaluation in cardiology. The exercise modalities most often used in CPET are the treadmill (TM) and upright bicycle (UB). Nowadays, also the supine bicycle (SB) is becoming more often used, especially when combined with cardiac imaging. OBJECTIVES: Our aim was to examine whether a maximal CPET on a SB leads to similar results as TM and UB in terms of different CPET measures. Secondly, we explored whether peak VO2 relates to the person's preference and experience with the different exercise modalities...
November 1, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27492533/relationships-between-emphysema-and-airways-metrics-at-high-resolution-computed-tomography-hrct-and-ventilatory-response-to-exercise-in-mild-to-moderate-copd-patients
#15
Ernesto Crisafulli, Veronica Alfieri, Mario Silva, Marina Aiello, Panagiota Tzani, Gianluca Milanese, Giuseppina Bertorelli, Nicola Sverzellati, Alfredo Chetta
BACKGROUND AND PURPOSE: In Chronic Obstructive Pulmonary Disease (COPD) patients, the opportunity to carry out a thoracic high-resolution CT (HRCT) scan and to perform an incremental cardiopulmonary exercise test (CPET) increases the possibility to identify the different clinical features of disease. The aim of our study was to evaluate the relationships between HRCT metrics (on emphysema by low attenuation areas-LAA% and airways by wall area-WA%) and CPET variables related to the dynamic response to exercise in terms of elastic balance (Δ rest-to-peak IC/TLC) and ventilation capacity for carbon dioxide output (VE/VCO2slope and VE/VCO2 intercept)...
August 2016: Respiratory Medicine
https://www.readbyqxmd.com/read/27418685/exercise-physiological-responses-to-drug-treatments-in-chronic-thromboembolic-pulmonary-hypertension
#16
Athanasios Charalampopoulos, J Simon R Gibbs, Rachel J Davies, Wendy Gin-Sing, Kevin Murphy, Karen K Sheares, Joanna Pepke-Zaba, David P Jenkins, Luke S Howard
We tested the hypothesis that patients with chronic thromboembolic pulmonary hypertension (CTEPH) that was deemed to be inoperable were more likely to respond to drugs for treating pulmonary arterial hypertension (PAH) by using cardiopulmonary exercise (CPX) testing than those with CTEPH that was deemed to be operable. We analyzed CPX testing data of all patients with CTEPH who were treated with PAH drugs and had undergone CPX testing before and after treatment at a single pulmonary hypertension center between February 2009 and March 2013...
September 1, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/27415618/changes-in-hepatic-venous-pressure-gradient-induced-by-physical-exercise-in-cirrhosis-results-of-a-pilot-randomized-open-clinical-trial
#17
Ricardo U Macías-Rodríguez, Hermes Ilarraza-Lomelí, Astrid Ruiz-Margáin, Sergio Ponce-de-León-Rosales, Florencia Vargas-Vorácková, Octavio García-Flores, Aldo Torre, Andrés Duarte-Rojo
OBJECTIVES: Exercise has been scarcely studied in patients with cirrhosis, and prior evidence showed hepatic venous pressure gradient (HVPG) to be increased in response to exercise. The aim of this study was to investigate the effects of a supervised physical exercise program (PEP) in patients with cirrhosis. METHODS: In an open-label, pilot clinical trial, patients with cirrhosis were randomized to PEP (cycloergometry/kinesiotherapy plus nutritional therapy, n=14) or control (nutritional therapy, n=15); for 14 weeks...
2016: Clinical and Translational Gastroenterology
https://www.readbyqxmd.com/read/27335689/hemodynamic-and-metabolic-response-during-dynamic-and-resistance-exercise-in-different-intensities-a-cross-sectional-study-on-implications-of-intensity-on-safety-and-symptoms-in-patients-with-coronary-disease
#18
Flavia Rossi Caruso, Jose Carlos Bonjorno Junior, Renata G Mendes, Milena Pelosi Sperling, Vivian M Arakelian, Daniela Bassi, Ross Arena, Audrey Borghi-Silva
Resistance (RE) and aerobic exercise (AE) can promote hemodynamic, physiologic and clinical modifications in coronary artery disease (CAD) patients. The aim of the study is to assess key physiologic and clinical responses during RE at 30% and 60% of 1-RM on a 45° leg press and to compare responses during AE. We evaluated fifteen male subjects with coronary artery disease (60.8±4.7 years) that performed the following tests: (1) incremental AE test on cycle ergometer; (2) 1-RM test on a leg press at 45°; (3) and RE at 30% and 60% of 1-RM for 24 repetitions...
2016: American Journal of Cardiovascular Disease
https://www.readbyqxmd.com/read/27327769/functional-characterization-of-patients-with-chronic-thromboembolic-disease
#19
Matthias Held, Philipp Kolb, Maria Grün, Berthold Jany, Gudrun Hübner, Aleksandar Grgic, Regina Holl, Hans-Joachim Schaefers, Heinrike Wilkens
BACKGROUND: Patients with chronic thromboembolic pulmonary disease (CTED) have persistent pulmonary vascular obstruction and exercise intolerance without pulmonary hypertension at rest and may benefit from pulmonary endarterectomy. However, up to now, CTED has been poorly characterized. OBJECTIVES: This study aimed to analyze the exercise capacity and limiting factors in CTED. METHODS: We compared right heart catheterization and cardiopulmonary exercise test results of patients with CTED [mean pulmonary artery pressure (mPAP) at rest <25 mm Hg, n = 10], chronic thromboembolic pulmonary hypertension (CTEPH, n = 31) and a control group (n = 41) presenting with dyspnea but normal pulmonary vascular imaging and excluded pulmonary hypertension...
2016: Respiration; International Review of Thoracic Diseases
https://www.readbyqxmd.com/read/27210854/effects-of-manual-percussion-during-postural-drainage-on-lung-volumes-and-metabolic-status-in-healthy-subjects
#20
Jirakrit Leelarungrayub, Wichai Eungpinichpong, Jakkrit Klaphajone, Mujalin Prasannarong, Kritsana Boontha
OBJECTIVE: The aim of this study was to evaluate the influence of manual percussion during three different positions of postural drainage (PD) on lung volumes and metabolic status. METHODS: Twenty six healthy volunteers (13 women and 13 men), with a mean age of 20.15 ± 1.17 years, participated. They were randomized into three standard positions of PD (upper, middle, or lower lobes) and given manual percussion at a frequency of 240 times per minute for 5 min...
April 2016: Journal of Bodywork and Movement Therapies
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