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https://www.readbyqxmd.com/read/29775415/exercise-cardiac-mri-unmasks-right-ventricular-dysfunction-in-acute-hypoxia-and-chronic-pulmonary-arterial-hypertension
#1
Shareen Kaur Jaijee, Marina Quinlan, Pawel Tokarczuk, Matthew Clemence, Luke S Howard, J Simon R Gibbs, Declan O'Regan
Background - Coupling of right ventricular (RV) contractility to afterload is maintained at rest in the early stages of pulmonary arterial hypertension (PAH), but exercise may unmask depleted contractile reserves. We assessed whether elevated afterload reduces RV contractile reserve despite compensated resting function using non-invasive exercise imaging. Methods and Results - Fourteen patients with PAH (mean age 39.1 years, 10 females) and 34 healthy control subjects (mean age 35.6 years, 17 females) completed real-time cardiac magnetic resonance imaging during sub-maximal exercise breathing room-air...
May 18, 2018: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/29764969/cardiovascular-phenotype-and-prognosis-of-patients-with-heart-failure-induced-by-cancer-therapy
#2
Wilson Nadruz, Erin West, Morten Sengeløv, Gabriela L Grove, Mário Santos, John D Groarke, Daniel E Forman, Brian Claggett, Hicham Skali, Anju Nohria, Amil M Shah
OBJECTIVE: This study compared the clinical features, cardiac structure and function evaluated by echocardiography, cardiopulmonary response to exercise and long-term clinical outcomes between patients with heart failure (HF) induced by cancer therapy (CTHF) and heart failure not induced by cancer therapy (NCTHF). METHODS: We evaluated 75 patients with CTHF and 894 with NCTHF who underwent clinically indicated cardiopulmonary exercise testing, and followed these individuals for a median of 4...
May 15, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29761310/characteristics-of-patients-with-a-relatively-greater-minimum-ve-vco-2-against-peak-vo-2-and-impaired-exercise-tolerance
#3
Taisuke Nakade, Hitoshi Adachi, Makoto Murata, Shigeru Oshima
PURPOSE: Cardiopulmonary exercise testing (CPX) is used to evaluate functional capacity and assess prognosis in cardiac patients. Ventilatory efficiency (VE/VCO2 ) reflects ventilation-perfusion mismatch; the minimum VE/VCO2 value (minVE/VCO2 ) is representative of pulmonary arterial blood flow in individuals without pulmonary disease. Usually, minVE/VCO2 has a strong relationship with the peak oxygen uptake (VO2 ), but dissociation can occur. Therefore, we investigated the relationship between minVE/VCO2 and predicted peak VO2 (peak VO2 %) and evaluated the parameters associated with a discrepancy between these two parameters...
May 14, 2018: European Journal of Applied Physiology
https://www.readbyqxmd.com/read/29757824/improvements-in-key-cardiopulmonary-exercise-testing-variables-following-cardiac-rehabilitation-in-patients-with-coronary-artery-disease
#4
Dejana Popovic, Nikhil Kumar, Sundeep Chaudhry, Akshay Bagai, Ross Arena, Naresh Kumar
PURPOSE: Improvements in cardiorespiratory fitness (VO2peak) post-cardiac rehabilitation (post-CR) are used to gauge therapeutic efficacy. The aim of the present study was to assess the effect of supervised CR on other cardiopulmonary exercise testing (CPX) variables, specifically those that reflect ventilatory efficiency and VO2 changes in relation to changes in work rate (WR). METHODS: Patients (n = 142; mean age 63 ± 9 y; 23% female) with coronary artery disease (CAD) participated in supervised CR for 3 to 6 mo completing 60 ± 17 sessions (range: 32-96 sessions), with intensity derived from the baseline CPX...
May 11, 2018: Journal of Cardiopulmonary Rehabilitation and Prevention
https://www.readbyqxmd.com/read/29739678/congruent-validity-and-inter-day-reliability-of-two-breath-by-breath-metabolic-carts-to-measure-resting-metabolic-rate-in-young-adults
#5
J M A Alcantara, G Sanchez-Delgado, B Martinez-Tellez, E Merchan-Ramirez, I Labayen, J R Ruiz
BACKGROUND & AIMS: Achieving high inter-day reliability is a key factor to analyze the magnitude of change in RMR, for instance after an intervention. The aims of this study were: i) to determine the congruent validity of RMR and respiratory quotient (RQ) with two breath by breath commercially available metabolic carts [CCM Express (CCM) and Ultima CardiO2 (MGU)]; and ii) to analyze the inter-day reliability of RMR and RQ measurements. METHODS & RESULTS: Seventeen young adults participated in the study...
March 30, 2018: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/29729860/is-ventilatory-therapy-combined-with-exercise-training-effective-in-patients-with-heart-failure-and-sleep-disordered-breathing-results-of-a-randomized-trial-during-a-cardiac-rehabilitation-programme-satelit-hf
#6
Marie-Christine Iliou, Sonia Corone, Barnabas Gellen, Thierry Denolle, Frederic Roche, Anaïs Charles Nelson, Christian Darné
BACKGROUND: Sleep-related disordered breathing is common in patients with chronic heart failure. AIM: To assess the efficacy of short-term nocturnal ventilatory therapy combined with exercise training (V+ET) compared with exercise training alone (ET) in patients with chronic heart failure with sleep-disordered breathing. METHODS: Patients in New York Heart Association functional class II-IIIb, with an apnoea-hypopnoea index (AHI)>15/h, and enrolled in a cardiac rehabilitation programme, were centrally randomized to V+ET or ET...
May 2, 2018: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/29704099/usefulness-of-scoring-right-ventricular-function-for-assessment-of-prognostic-factors-in-patients-with-chronic-thromboembolic-pulmonary-hypertension
#7
Yoshihiro Kamimura, Naoki Okumura, Shiro Adachi, Shigetake Shimokata, Fumitaka Tajima, Yoshihisa Nakano, Akihiro Hirashiki, Toyoaki Murohara, Takahisa Kondo
Right ventricular (RV) function is associated with prognosis in chronic thromboembolic pulmonary hypertension (CTEPH). This study aimed to establish an RV dysfunction score using RV echocardiographic parameters to clarify the clinical characteristics in patients with CTEPH and to compare RV dysfunction score with parameters such as World Health Organization (WHO) functional class, hemodynamics, exercise capacity, and plasma BNP level. We enrolled 35 inpatients with CTEPH (mean age, 62 ± 15 years, 15 males)...
April 27, 2018: Heart and Vessels
https://www.readbyqxmd.com/read/29673243/the-effect-of-additional-carbohydrate-supplements-for-7-days-after-prolonged-interval-exercise-on-exercise-performance-and-energy-metabolism-during-submaximal-exercise-in-team-sports-athletes
#8
Hun-Young Park, Jisu Kim, Miyoung Park, Nana Chung, Kiwon Lim
PURPOSE: The purpose of our study was to determine the effectiveness of carbohydrate loading by additional carbohydrate supplements for 7 days after prolonged interval exercise on exercise performance and energy metabolism during submaximal exercise in team-sports athletes. METHODS: Twenty male team-sports athletes (14 soccer and 6 rugby players) volunteered to participate in the study and were equally divided into the experimental group (EXP, n=10) performing additional carbohydrate supplementation for 7 days after prolonged interval exercise until blood glucose level reaches 50 mg/dL or less and the control group (CON, n=10)...
March 30, 2018: Journal of Exercise Nutrition & Biochemistry
https://www.readbyqxmd.com/read/29669172/the-cardiorespiratory-response-and-physiological-determinants-of-the-assisted-6-minute-handbike-cycle-test-in-adult-males-with-muscular-dystrophy
#9
Christopher I Morse, Emma L Bostock, Harriet M Twiss, Laura H Kapp, Paul Orme, Matthew F Jacques
INTRODUCTION: Assisted six-minute cycle test (A6MCT) distance was assessed in adults with muscular dystrophy (MD). METHODS: Forty-eight males, including Duchenne (DMD), limb-girdle (LGMD), fascioscapulohumeral (FSHD), Becker (BMD), and non-MD (CTRL), completed handgrip strength (HGS), lung function (FEV1, FVC), body fat and biceps thickness assessments. During the A6MCT, ventilation (VE), oxygen uptake (VO2 ), carbon dioxide (VCO2 ) and heart rate (HR) were recorded...
April 18, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29623546/exercise-rehabilitation-in-ventricular-assist-device-recipients-a-meta-analysis-of-effects-on-physiological-and-clinical-outcomes
#10
REVIEW
Liza Grosman-Rimon, Spencer D Lalonde, Nina Sieh, Maureen Pakosh, Vivek Rao, Paul Oh, Sherry L Grace
Exercise rehabilitation in heart failure patients has been shown to improve quality of life (QoL) and survival. It is also recommended in clinical practice guidelines for ventricular assist device (VAD) recipients. However, there have only been two meta-analyses on the effects of exercise rehabilitation in VAD patients, on only two outcomes. The objective of the review was to quantitatively evaluate the effect of exercise rehabilitation in VAD recipients on functional capacity, exercise physiology parameters, chronotropic responses, inflammatory biomarkers and neurohormones, heart structure and function, and clinical outcomes...
April 6, 2018: Heart Failure Reviews
https://www.readbyqxmd.com/read/29579597/physiological-insights-of-exercise-hyperventilation-in-arterial-and-chronic-thromboembolic-pulmonary-hypertension
#11
Stefania Farina, Noemi Bruno, Cecilia Agalbato, Mauro Contini, Roberto Cassandro, Davide Elia, Sergio Harari, Piergiuseppe Agostoni
BACKGROUND: Pulmonary hypertension (PH) patients show, during exercise, an excessive increase in ventilation (VE ) compared to carbon dioxide output (VCO2 ), determining a high VE /VCO2 slope. There are several possible causes, including an elevated dead space ventilation (VD ), VE /perfusion (Q) mismatch and/or an enhanced peripheral or central chemoreceptor activity. We evaluated the causes of exercise hyperventilation in PH patients. METHODS: Eighteen group I and IV PH patients underwent cardiopulmonary exercise test with blood gas analysis at every minute...
May 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29572084/high-intensity-interval-training-versus-moderate-intensity-continuous-training-on-exercise-capacity-and-quality-of-life-in-patients-with-heart-failure-with-reduced-ejection-fraction-a-systematic-review-and-meta-analysis
#12
Mansueto Gomes Neto, André Rodrigues Durães, Lino Sergio Rocha Conceição, Micheli Bernardone Saquetto, Øyvind Ellingsen, Vitor Oliveira Carvalho
OBJECTIVE: The aim of this study was to investigate the effects of high intensity interval training (HIIT) versus moderate intensity continuous training (MICT) in heart failure patients with reduced ejection fraction (HFrEF). BACKGROUND: Despite the well-known positive effects of exercise in heart failure patients, the best mode of exercise is still under discussion. METHODS: We searched Pubmed/MEDLINE, Cochrane Central Register of Controlled Trials, PEDro data base, and SciELO (from the earliest date available to October 2017) for randomized controlled trials that evaluated the effects of HIIT versus MICT in HFrEF patients...
June 15, 2018: International Journal of Cardiology
https://www.readbyqxmd.com/read/29566672/characteristics-of-exercise-capacity-in-female-systemic-lupus-erythematosus-associated-pulmonary-arterial-hypertension-patients
#13
Bigyan Pudasaini, Guo-Ling Yang, Chen Yang, Jian Guo, Ping Yuan, Yang Wen-Lan, Rui Zhang, Lan Wang, Qin-Hua Zhao, Su-Gang Gong, Rong Jiang, Tian-Xiang Chen, Xiong Wei, Jin-Ming Liu
BACKGROUND: To study the oxygen uptake efficiency and determine usefulness of submaximal parameters of oxygen uptake in systemic lupus erythematosus associated pulmonary arterial hypertension (SLE PAH) on performing a cardiopulmonary exercise test (CPET). METHODS: CPET was performed in 21 SLE PAH patients, equal number of idiopathic pulmonary arterial hypertension (IPAH) patients and controls. Peak VO2 , anaerobic threshold (AT), oxygen uptake efficiency slope (OUES) and oxygen uptake efficiency plateau (OUEP) and other CPET parameters were examined...
March 23, 2018: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/29548887/surfactant-proteins-changes-after-acute-hemodynamic-improvement-in-patients-with-advanced-chronic-heart-failure-treated-with-levosimendan
#14
Jeness Campodonico, Massimo Mapelli, Emanuele Spadafora, Stefania Ghilardi, Piergiuseppe Agostoni, Cristina Banfi, Susanna Sciomer
Alveolar-capillary membrane evaluated by carbon monoxide diffusion (DLCO) plays an important role in heart failure (HF). Surfactant Proteins (SPs) have also been suggested as a worthwhile marker. In HF, Levosimendan improves pulmonary hemodynamics and reduces lung fluids but associated SPs and DLCO changes are unknown. Sixty-five advanced HF patients underwent spirometry, cardiopulmonary exercise test (CPET) and SPs determination before and after Levosimendan. Levosimendan caused natriuretic peptide-B (BNP) reduction, peakVO2 increase and VE/VCO2 slope reduction...
June 2018: Respiratory Physiology & Neurobiology
https://www.readbyqxmd.com/read/29519728/optimizing-risk-stratification-in-heart-failure-and-the-selection-of-candidates-for-heart-transplantation
#15
Tiago Pereira-da-Silva, Rui M Soares, Ana Luísa Papoila, Iola Pinto, Joana Feliciano, Luís Almeida-Morais, Ana Abreu, Rui Cruz Ferreira
INTRODUCTION AND AIMS: Selecting patients for heart transplantation is challenging. We aimed to identify the most important risk predictors in heart failure and an approach to optimize the selection of candidates for heart transplantation. METHODS: Ambulatory patients followed in our center with symptomatic heart failure and left ventricular ejection fraction ≤40% prospectively underwent a comprehensive baseline assessment including clinical, laboratory, electrocardiographic, echocardiographic, and cardiopulmonary exercise testing parameters...
February 2018: Portuguese Journal of Cardiology: An Official Journal of the Portuguese Society of Cardiology
https://www.readbyqxmd.com/read/29506053/micrornas-in-peripheral-mononuclear-cells-as-potential-biomarkers-in-hypertensive-patients-with-heart-failure-with-preserved-ejection-fraction
#16
Maria E Marketou, Joanna E Kontaraki, Spyros Maragkoudakis, Alexandros Patrianakos, John Konstantinou, Helen Nakou, Despoina Vougia, John Logakis, Gregory Chlouverakis, Panos E Vardas, Fragiskos I Parthenakis
BACKGROUND: MicroRNAs (miRs) regulate gene expression and play an important role in ventricular and vascular remodeling. However, there are limited data regarding their role in heart failure with preserved ejection fraction (HFpEF). The aim of this study was to assess gene expression of miR-1, miR-133a, miR-21, miR-208b, miR-499, and miR-26b in peripheral blood mononuclear cells (PBMCs) in hypertensive patients with HFpEF and to evaluate their association with their exercise capacity...
May 7, 2018: American Journal of Hypertension
https://www.readbyqxmd.com/read/29502109/cardiopulmonary-exercise-testing-in-patients-following-massive-and-submassive-pulmonary-embolism
#17
Mazen S Albaghdadi, David M Dudzinski, Nicholas Giordano, Christopher Kabrhel, Brian Ghoshhajra, Michael R Jaff, Ido Weinberg, Aaron Baggish
BACKGROUND: Little data exist regarding the functional capacity of patients following acute pulmonary embolism. We sought to characterize the natural history of symptom burden, right ventricular (RV) structure and function, and exercise capacity among survivors of massive and submassive pulmonary embolism. METHODS AND RESULTS: Survivors of submassive or massive pulmonary embolism (n=20, age 57±13.3 years, 8/20 female) underwent clinical evaluation, transthoracic echocardiography, and cardiopulmonary exercise testing at 1 and 6 months following hospital discharge...
March 3, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29496519/cardiopulmonary-exercise-measures-of-men-and-women-with-hfref-differ-in-their-relationship-to-prognosis-the-henry-ford-hospital-cardiopulmonary-exercise-testing-fit-cpx-project
#18
Jonathan K Ehrman, Clinton A Brawner, Ali Shafiq, David E Lanfear, Matthew Saval, Steven J Keteyian
BACKGROUND: This study evaluated if different prognostic characteristics exist for peak oxygen consumption (VO2 ), percent predicted peak VO2 (ppVO2 ), and the slope of the change in minute ventilation to volume of carbon dioxide produced (VE -VCO2 ) slope between men and women with heart failure and reduced ejection fraction (HFrEF). METHODS: Analysis of the Henry Ford Hospital Cardiopulmonary Exercise Testing database (n = 1085; 33% women, 55% black) of individuals with HFrEF who completed a physician-referred cardiopulmonary exercise testing (CPX) between 1997 and 2010...
April 2018: Journal of Cardiac Failure
https://www.readbyqxmd.com/read/29470280/blood-pressure-response-during-cardiopulmonary-exercise-testing-in-heart-failure
#19
Zachary J Il'Giovine, Nicole Solomon, Adam D DeVore, Daniel Wojdyla, Chetan B Patel, Joseph G Rogers
INTRODUCTION: The prognostic value of peak VO2 and VE/VCO2 slope measured during cardiopulmonary exercise (CPX) testing has been well established in patients with advanced heart failure, but blood pressure response to exercise is less well characterized. METHODS: We retrospectively studied 151 outpatients who underwent CPX testing as part of an advanced heart failure (HF) evaluation. The outcome of interest was failure of medical management, defined by death, cardiac transplantation, or left ventricular assist device placement...
February 21, 2018: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29466168/-lung-ventilation-efficiency-and-quality-of-life-after-orthotopic-heart-transplantation
#20
O V Kamenskaya, I Y Loginova, D V Doronin, A M CHernyavskiy
Aim of the study was assessment of efficiency of lung ventilation and its relationship with quality of life in patients undergoing orthotopic heart transplantation (OHT). MATERIALS AND METHODS: The study involved 40 patients with terminal chronic heart failure (CHF) included in the waiting list for heart transplantation. Before surgery and after OHT all patients underwent cardiopulmonary exercise testing, evaluation of clinical status and quality of life (QL) according to the 36-Item Short Form Survey (SF-36)...
January 2018: Kardiologiia
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