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https://www.readbyqxmd.com/read/28636995/experimental-study-on-the-therapeutic-effect-and-underlining-mechanisms-of-positron-in-pancreatic-cancer-cells
#1
Ying Wang, Ming Li, Rao Diao, Brian Tung, Dalong Zhang, Yaming Li
The purpose of this study was to assess the potential therapeutic effect of positrons emitted by 18F-2-Deoxy-2-Fluoro-D-Glucose (18F-FDG) on pancreatic cancer cells and elucidate its underlying mechanisms. Pancreatic cancer cells were incubated with different radioactive concentrations of 18F-FDG and evaluated for anti-cancer properties and underlining mechanisms. In addition, three groups of tumor-bearing mice were treated with different doses of 18F-FDG weekly, the tumor growth rate was calculated, and the mice were imaged by positron emission tomography (PET) with 18F-FDG before and after treatment...
June 5, 2017: Oncotarget
https://www.readbyqxmd.com/read/28635336/new-advances-in-focal-therapy-for-early-stage-prostate-cancer
#2
Kae Jack Tay, Ariel A Schulman, Christina Sze, Efrat Tsivian, Thomas J Polascik
Prostate focal therapy offers men the opportunity to achieve oncological control while preserving sexual and urinary function. The prerequisites for successful focal therapy are to accurately identify, localize and completely ablate the clinically significant cancer(s) within the prostate. We aim to evaluate the evidence for current and upcoming technologies that could shape the future of prostate cancer focal therapy in the next five years. Areas Covered: Current literature on advances in patient selection using imaging, biopsy and biomarkers, ablation techniques and adjuvant treatments for focal therapy are summarized...
June 21, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/28634684/heterogeneity-index-evaluated-by-slope-of-linear-regression-on-18-f-fdg-pet-ct-as-a-prognostic-marker-for-predicting-tumor-recurrence-in-pancreatic-ductal-adenocarcinoma
#3
Yong-Il Kim, Yong Joong Kim, Jin Chul Paeng, Gi Jeong Cheon, Dong Soo Lee, June-Key Chung, Keon Wook Kang
PURPOSE: (18)F-Fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) has been investigated as a method to predict pancreatic cancer recurrence after pancreatic surgery. We evaluated the recently introduced heterogeneity indices of (18)F-FDG PET/CT used for predicting pancreatic cancer recurrence after surgery and compared them with current clinicopathologic and (18)F-FDG PET/CT parameters. METHODS: A total of 93 pancreatic ductal adenocarcinoma patients (M:F = 60:33, mean age = 64...
June 20, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28632698/primary-cutaneous-angiosarcoma-mimicking-metastasis-on-18f-fdg-pet-ct-in-woman-with-cervix-cancer
#4
Jae Pil Hwang
Primary cutaneous angiosarcoma is a rare vascular tumor usually affecting the whole body, and its hypermetabolic features on F-FDG PET/CT may be confused with those of infection, metastasis, or primary malignancy. This is a case report of a cutaneous angiosarcoma of the lower anterior abdomen showing increased FDG uptake on F-FDG PET/CT mimicking a cutaneous metastasis in an 84-year-old woman with cervical cancer.
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632693/extraosseous-extension-of-aggressive-vertebral-hemangioma-as-a-potential-pitfall-on-68ga-psma-pet-ct
#5
Stephan Probst, Franck Bladou, Gad Abikhzer
A 74-year-old man with newly diagnosed prostate cancer underwent Ga-PSMA PET/CT, which demonstrated intense uptake in and adjacent the L2 vertebral body. Subsequent MRI of the lumbar spine showed an aggressive L2 hemangioma with adjacent soft tissue extension. There was congruence of the intraosseous and extraosseous components of the hemangioma and the PSMA PET uptake. This is a rare but important potential pitfall in Ga-PSMA PET/CT-a soft tissue lesion with intense tracer uptake related not to a nodal metastasis of prostate cancer but to extraosseous extension of an aggressive vertebral body hemangioma...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28632689/18f-fdg-uptake-in-ischemic-colitis-during-follow-up-of-a-patient-with-lung-cancer
#6
Sofia C Vaz, Carla Oliveira, Joana C Castanheira, Ângelo F Silva, Durval C Costa
A 61-year-old man with previous history of lung adenocarcinoma underwent 2 F-FDG PET/CT investigations. The first for assessment of enlarged mediastinal lymph nodes revealed an area of increased FDG uptake in the sigmoid colon (located at the right pelvis). Colonoscopy showed a segmental area of ischemic sigmoid colitis, confirmed on histology postbiopsy. The asymptomatic man had no risk factors, and no specific treatment was administered, apart from supportive measures. One year later, there was no significantly abnormal uptake on PET/CT...
June 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28627323/perspective-of-%C3%AE-v%C3%AE-6-integrin-imaging-for-clinical-management-of-pancreatic-carcinoma-and-its-precursor-lesions
#7
Katja Steiger, Anna-Melissa Schlitter, Wilko Weichert, Irene Esposito, Hans-Jürgen Wester, Johannes Notni
ß6-integrin immunohistochemistry analysis of a large number of pancreatic ductal adenocarcinoma (PDAC, 383 primary tumors, 7 lymph node, and 8 distant metastases) and 34 pancreatic intraepithelial neoplasia (PanIN) specimens revealed a high prevalence of αvß6-integrin expression in PDAC primaries (88%) and in almost all metastases, as well as in PanIN (57%). These findings underscore the high potential of a novel αvß6-integrin targeting positron emission tomography (PET) radiopharmaceutical, Ga-68-Avebehexin, for early diagnosis of pancreatic cancer...
January 1, 2017: Molecular Imaging
https://www.readbyqxmd.com/read/28625649/investigation-of-patterns-of-nodal-metastases-in-braf-mutant-lung-cancer
#8
S H McEvoy, D F Halpenny, A Viteri-Jusué, S A Hayes, A J Plodkowski, G J Riely, M S Ginsberg
Axillary lymph nodes (axLN) are a rare site of nodal metastases in patients with lung cancer. BRAF mutated lung cancer is a genetically distinct subtype that occurs in 2-5% of non-small cell lung carcinomas (NSCLC). A recent study identified a highly unusual pattern of metastatic spread to axLN in patients with BRAF mutated colorectal cancer (CRC). The purpose of the study is to assess the incidence of axLN metastases in BRAF mutated NSCLC. Baseline computed tomography (CT) imaging at diagnosis and all follow up CTs of patients with BRAF mutated NSCLC treated at our institution were retrospectively reviewed by two radiologists for evidence of axLN metastases...
June 2017: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/28625410/sialadenoma-papilliferum-in-the-buccal-mucosa-detected-on-18-f-fluorodeoxyglucose-positron-emission-tomography
#9
S Miyamoto, T Ogawa, D Chikazu
An incidental discovery of an accumulation of (18)F-fluorodeoxyglucose (FDG) in the oral cavity of patients with malignant tumours on FDG positron emission tomography (PET) can pose a problem regarding the differential diagnosis of metastatic lesions. Large accumulations can often be found even when tumours in the salivary or thyroid gland are benign, so FDG-PET is limited in its ability to differentiate between benign and malignant disease. This report describes a rare case of sialadenoma papilliferum in the buccal mucosa that was discovered incidentally on FDG-PET in a patient with multiple metastases to bone after an operation for rectal cancer...
June 15, 2017: British Journal of Oral & Maxillofacial Surgery
https://www.readbyqxmd.com/read/28624849/the-accuracy-of-68-ga-psma-pet-ct-in-primary-lymph-node-staging-in-high-risk-prostate-cancer
#10
Can Öbek, Tünkut Doğanca, Emre Demirci, Meltem Ocak, Ali Rıza Kural, Asıf Yıldırım, Uğur Yücetaş, Çetin Demirdağ, Sarper M Erdoğan, Levent Kabasakal
PURPOSE: To assess the diagnostic accuracy of (68)Ga-PSMA PET in predicting lymph node (LN) metastases in primary N staging in high-risk and very high-risk nonmetastatic prostate cancer in comparison with morphological imaging. METHODS: This was a multicentre trial of the Society of Urologic Oncology in Turkey in conjunction with the Nuclear Medicine Department of Cerrahpasa School of Medicine, Istanbul University. Patients were accrued from eight centres. Patients with high-risk and very high-risk disease scheduled to undergo surgical treatment with extended LN dissection between July 2014 and October 2015 were included...
June 18, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28624803/prognostic-significance-of-pd-l1-expression-and-18f-fdg-pet-ct-in-surgical-pulmonary-squamous-cell-carcinoma
#11
Minghui Zhang, Dalong Wang, Qi Sun, Haihong Pu, Yan Wang, Shu Zhao, Yan Wang, Qiangyuan Zhang
Programmed cell death-ligand 1 (PD-L1) expression is commonly observed in non-small cell lung cancer (NSCLC). The prognostic value of PD-L1 expression and the maximum standardized uptake value (SUVmax) on 18F-Fluorodeoxyglucose positron emission tomography (18FDG-PET) in surgical pulmonary squamous cell carcinoma(SCC)remains unclear. Furthermore, the correlation between the SUVmax and PD-L1 expression has not been assessed. Thus, the purpose of this study was to investigate the correlation between PD-L1 expression and the SUVmax on 18FDG-PET and to examine the prognostic significance of PD-L1 expression and the SUVmax in surgical pulmonary SCC...
May 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28624021/assessment-of-treatment-response-after-lung-stereotactic-body-radiotherapy-using-diffusion-weighted-magnetic-resonance-imaging-and-positron-emission-tomography-a-pilot-study
#12
Takashi Shintani, Yukinori Matsuo, Yusuke Iizuka, Takamasa Mitsuyoshi, Shigeaki Umeoka, Yuji Nakamoto, Takashi Mizowaki, Kaori Togashi, Masahiro Hiraoka
BACKGROUND AND PURPOSE: There is no early predictor of treatment response after lung stereotactic body radiotherapy (SBRT). We conducted this pilot study to evaluate whether serial diffusion weighted magnetic resonance imaging (DW-MRI) or positron emission tomography (PET) could predict response after SBRT. MATERIAL AND METHODS: Early stage non-small cell lung cancer patients who received SBRT were eligible. DW-MRI and PET were undertaken pretreatment and every 3 months after SBRT in the first year...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624017/association-of-pharmacokinetic-and-metabolic-parameters-derived-using-simultaneous-pet-mri-initial-findings-and-impact-on-response-evaluation-in-breast-cancer
#13
Amarnath Jena, Sangeeta Taneja, Aru Singh, Pradeep Negi, Shashi Bhushan Mehta, Aashim Ahuja, Manish Singhal, Ramesh Sarin
PURPOSE: To study relationships among pharmacokinetic and (18)F-fluorodeoxyglucose ((18)F-FDG) PET parameters obtained through simultaneous PET/MRI in breast cancer patients and evaluate their combined potential for response evaluation. METHODS: The study included 41 breast cancer patients for correlation study and 9 patients (pre and post therapy) for response evaluation. All patients underwent simultaneous PET/MRI with dedicated breast imaging. Pharmacokinetic parameters and PET parameters for tumor were derived using an in- house developed and vendor provided softwares respectively...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28624015/imaging-modalities-in-the-diagnosis-of-pancreatic-adenocarcinoma-a-systematic-review-and-meta-analysis-of-sensitivity-specificity-and-diagnostic-accuracy
#14
James Toft, William J Hadden, Jerome M Laurence, Vincent Lam, Lawrence Yuen, Anna Janssen, Henry Pleass
BACKGROUND: Pancreatic cancer, primarily pancreatic ductal adenocarcinoma (PDAC), accounts for 2.4% of cancer diagnoses and 5.8% of cancer death annually. Early diagnoses can improve 5-year survival in PDAC. The aim of this systematic review was to determine the sensitivity, specificity and diagnostic accuracy values for MRI, CT, PET&PET/CT, EUS and transabdominal ultrasound (TAUS) in the diagnosis of PDAC. METHODS: A systematic review was undertaken to identify studies reporting sensitivity, specificity and/or diagnostic accuracy for the diagnosis of PDAC with MRI, CT, PET, EUS or TAUS...
July 2017: European Journal of Radiology
https://www.readbyqxmd.com/read/28623852/frusemide-aids-diagnostic-interpretation-of-68-ga-psma-positron-emission-tomography-ct-in-men-with-prostate-cancer
#15
Niall Fennessy, Jonathan Lee, Jane Shin, Bao Ho, Syed Aman Ali, Royce Paschkewitz, Louise Emmett
INTRODUCTION: (68) Ga-PSMA positron emission tomography-computed tomography (PET/CT) is useful for both staging and assessment of biochemical relapse in men with prostate cancer. Renal excretion of (68) Ga-PSMA can lead to difficulties in scan interpretation, particularly in the pelvis. We evaluated if intravenous Frusemide at the time of (68) Ga-PSMA injection reduces excreted activity artefact and improves diagnostic certainty. METHODS: Sixty-two men with prostate cancer undergoing clinically indicated (68) Ga-PSMA PET/CT were prospectively included, 30 men receiving Frusemide at the time of radiotracer injection...
June 17, 2017: Journal of Medical Imaging and Radiation Oncology
https://www.readbyqxmd.com/read/28623376/eanm-earl-harmonization-strategies-in-pet-quantification-from-daily-practice-to-multicentre-oncological-studies
#16
REVIEW
Nicolas Aide, Charline Lasnon, Patrick Veit-Haibach, Terez Sera, Bernhard Sattler, Ronald Boellaard
Quantitative positron emission tomography/computed tomography (PET/CT) can be used as diagnostic or prognostic tools (i.e. single measurement) or for therapy monitoring (i.e. longitudinal studies) in multicentre studies. Use of quantitative parameters, such as standardized uptake values (SUVs), metabolic active tumor volumes (MATVs) or total lesion glycolysis (TLG), in a multicenter setting requires that these parameters be comparable among patients and sites, regardless of the PET/CT system used. This review describes the motivations and the methodologies for quantitative PET/CT performance harmonization with emphasis on the EANM Research Ltd...
June 16, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28620878/incidental-colorectal-fdg-uptake-on-pet-ct-scan-and-lesions-observed-during-subsequent-colonoscopy-a-systematic-review
#17
REVIEW
S J Kousgaard, O Thorlacius-Ussing
BACKGROUND: Incidental colorectal fluorodeoxyglucose (FDG) uptake can be observed during a positron emission tomography/computed tomography (PET/CT) scan. For clinical and/or histological assessment of the cause, a colonoscopy is then performed. A systematic review was conducted to investigate the relationship between incidental colorectal FDG uptake and lesions observed during a subsequent colonoscopy. METHODS: A literature search was conducted using PubMed, Embase, and Web of Science with the keywords concerning PET/CT scan and colonoscopy...
June 15, 2017: Techniques in Coloproctology
https://www.readbyqxmd.com/read/28620348/the-utility-of-fdg-pet-ct-in-clinically-suspected-paraneoplastic-neurological-syndrome-a-literature-review-and-retrospective-case-series
#18
Mark P Maskery, Jonathan Hill, John R Cain, Hedley C A Emsley
Paraneoplastic neurological syndrome (PNS) describes a spectrum of rare, heterogeneous neurological conditions associated with an underlying malignancy. Diagnosis of PNS is inherently difficult, with frequent misdiagnosis and delay. The literature suggests an underlying immune-mediated pathophysiology, and patients are usually tested for the presence of onconeural antibodies. With direct tumor therapy being the most effective method of stabilizing patients, there is a strong emphasis on detecting underlying tumors...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28619734/-68-ga-psma11-pet-ct-in-newly-diagnosed-carcinoma-of-the-prostate-correlation-of-intraprostatic-psma-uptake-with-several-clinical-parameters
#19
Stefan A Koerber, Maximilian T Utzinger, Clemens Kratochwil, Claudia Kesch, Matthias Haefner, Sonja Katayama, Walter Mier, Andrei H Iagaru, Klaus Herfarth, Uwe Haberkorn, Juergen Debus, Frederik L Giesel
(68)Ga-prostate-specific membrane antigen (PSMA)-positron emission tomography (PET)/ computer tomography (CT) is a promising diagnostic tool for patients with prostate cancer. Our study evaluates standardized uptake values (SUV) in benign prostate tissue and malignant, intraprostatic tumor lesions and correlates results with several clinical parameters. Methods: One hundred and four men with newly diagnosed prostate carcinoma and no previous therapy were included in this study. Maximum SUV (SUVmax) was measured and correlated with biopsy findings and magnetic resonance imaging (MRI)...
June 15, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28619538/synthesis-and-biological-evaluation-of-2-3-4-dimethoxyphenyl-6-2-18-f-fluoroethoxy-benzothiazole-18-f-fedbt-for-pet-imaging-of-breast-cancer
#20
Geng-Ying Li, Daria D Vaulina, Jia-Je Li, Olga S Fedorova, Hsin-Ell Wang, Ren-Shyan Liu, Raisa N Krasikova, Chuan-Lin Chen
Given the ever-present demand for improved PET radiotracer in oncology imaging, we have synthesized 2-(3,4-dimethoxyphenyl)-6-(2-[(18)F]fluoroethoxy)benzothiazole ([(18)F]FEDBT), a fluorine-18-containing fluoroethylated benzothiazole to explore its utility as a PET imaging tracer. [(18)F]FEDBT was prepared via kryptofix-mediated nucleophilic substitution of the tosyl group precursor. Fractionated ethanol-based solid-phase (SPE cartridge-based) purification afforded [(18)F]FEDBT in 60% radiochemical yield (EOB), with radiochemical purity in excess of 98% and the specific activity was 35GBq/μmol...
May 26, 2017: Bioorganic & Medicinal Chemistry Letters
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