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REVIEW
Eloy Bejarano, Alicia Domenech-Bendaña, Norma Avila-Portillo, Sheldon Rowan, Sachini Edirisinghe, Allen Taylor
People are living longer and rates of age-related diseases such as age-related macular degeneration (AMD) are accelerating, placing enormous burdens on patients and health care systems. The quality of carbohydrate foods consumed by an individual impacts health. The glycemic index (GI) is a kinetic measure of the rate at which glucose arrives in the blood stream after consuming various carbohydrates. Consuming diets that favor slowly digested carbohydrates releases sugar into the bloodstream gradually after consuming a meal (low glycemic index)...
March 21, 2024: Progress in Retinal and Eye Research
#22
REVIEW
Lillian Xie, Lais Lopes Almeida Gomes, Caroline J Stone, Daniella Forman Faden, Victoria P Werth
Cutaneous lupus erythematosus (CLE) comprises dermatologic manifestations that may occur independently or with systemic lupus erythematosus (SLE). Despite advancements in refining CLE classification, establishing precise subtype criteria remains challenging due to overlapping presentations and difficulty in distinguishing morphology. Current treatments encompass preventive measures, topical therapies, and systemic approaches. Hydroxychloroquine and glucocorticoids are the sole US Food and Drug Administration (FDA)-approved medications for CLE, with numerous off-label treatments available...
March 15, 2024: Journal of Dermatology
#23
JOURNAL ARTICLE
Shih-Feng Cho, Tsung-Jang Yeh, Hui-Ching Wang, Jeng-Shiun Du, Yuh-Ching Gau, Yu-Yin Lin, Tzer-Ming Chuang, Yi-Chang Liu, Hui-Hua Hsiao, Sin-Hua Moi
The present study aimed to elucidate the prognostic mutation signature (PMS) associated with long-term survival in a diffuse large B-cell lymphoma (DLBCL) cohort. All data including derivation and validation cohorts were retrospectively retrieved from The Cancer Genome Atlas (TCGA) database and whole-exome sequencing (WES) data. The Lasso Cox regression analysis was used to construct the PMS based on WES data, and the PMS was determined using the area under the receiver operating curve (AUC). The predictive performance of eligible PMS was analyzed by time-dependent receiver operating curve (ROC) analyses...
March 14, 2024: Scientific Reports
#24
JOURNAL ARTICLE
Weijing Shang, Guiying Cao, Wenzhan Jing, Jue Liu, Wannian Liang, Min Liu
OBJECTIVE: Tuberculosis (TB) is a major health threat in adolescents and young adults. However, its burden in this population remains unclear. This study aimed to assess TB burden and changing trends in individuals aged 10 to 24 years from 1990 to 2019. METHODS: All data were obtained from the Global Burden of Disease Study 2019. We calculated the percentage of relative changes in incident cases, deaths, and disability-adjusted life years (DALYs). The temporal trends of the incidence, mortality, and DALYs were assessed using estimated annual percentage changes (EAPCs)...
April 1, 2024: Pediatrics
#25
JOURNAL ARTICLE
Joanie Huebner, Jade Robichaud, Julia S Cozart, Crystal Burkhardt, Sharon G Lynch, Jared M Bruce
BACKGROUND: Polypharmacy, or the use of 5 or more daily medications, is common in adults with multiple sclerosis (MS), and is often due to various physical, cognitive, and emotional symptoms. However, research regarding the association between polypharmacy and cognitive outcomes in MS is sparse. Furthermore, individuals with MS often use medications with anticholinergic properties, which are commonly associated with cognitive impairment and other central nervous system adverse effects...
2024: International Journal of MS Care
#26
JOURNAL ARTICLE
Charles Komen Chelimo, Paul Oyieng Angienda, Charles Ochieng Olwal, Henry Nyamogoba
BACKGROUND: Tuberculosis (TB) remains a high-burden infectious disease worldwide. Mycobacterium tuberculosis complex (MTBC) is the aetiological agent of TB. RESEARCH GAP: The TB burden is significantly linked to the development of drug-resistant strains. Thus, there is an urgent need for close surveillance of MTBC circulating in a given region, such as Western Kenya, for treatment of TB. AIM: To determine the proportion of MTBC species, strains and genetic diversities in circulation in HIV/AIDS-prevalent regions, and Western Kenya in particular...
2024: Access microbiology
#27
JOURNAL ARTICLE
Masunga K Iseselo, Joel S Ambikile, Gift G Lukumay, Idda H Mosha
BACKGROUND: Healthcare providers play an important role in the provision of health services in care and treatment clinics (CTCs), as they help clients cope with their HIV/AIDS diseases by providing health education and counseling. Little is known about the challenges that healthcare providers face when providing such services to people living with HIV (PLWH) in low-resource settings. This study aimed to explore and understand the challenges that healthcare providers face in delivering care to PLWH in Dar es Salaam, Tanzania...
2024: Front Health Serv
#28
JOURNAL ARTICLE
Cemile Ozsurekci, Neslihan Kayahan Satis, Sultan Keskin Demircan, Mehmet Ilkin Naharci
BACKGROUND: The purpose of this study was to investigate the relationship between anticholinergic burden (ACB), and cognitive and functional alterations in patients with dementia of Lewy bodies (DLB) during a 1-year follow-up period. METHODS: This cohort study included patients diagnosed with DLB admitted to a tertiary geriatric outpatient clinic. Cognition, functional performance, and nutritional status were assessed at baseline, 6 months, and 12 months during the follow-up period...
March 2024: Clinical Neuropharmacology
#29
JOURNAL ARTICLE
Yuxin Jin, Jingwei Wu, Kunlun Huang, Zhihong Liang
Ulcerative colitis (UC) is a global intestinal disease, and conventional therapeutic drugs often fail to meet the needs of patients. There is an urgent need to find efficient and affordable novel biological therapies. Saccharomyces boulardii has been widely used in food and pharmaceutical research due to its anti-inflammatory properties and gut health benefits. However, there is still a relatively limited comparison and evaluation of different forms of S. boulardii treatment for UC. This study aimed to compare the therapeutic effects of S...
February 29, 2024: Nutrients
#30
JOURNAL ARTICLE
Luis Prats-Sanchez, Pol Camps-Renom, Philip S Nash, Duncan Wilson, Gareth Ambler, Jonathan G Best, Marina Guasch-Jiménez, Anna Ramos-Pachón, Alejandro Martinez-Domeño, Álvaro Lambea-Gil, Garbiñe Ezcurra Díaz, Daniel Guisado-Alonso, Houwei Du, Rustam Al-Shahi Salman, Hans Rolf Jäger, Gregory Y Lip, Hakan Ay, Simon Jung, Natan M Bornstein, Thomas Gattringer, Sebastian Eppinger, Dianne H van Dam-Nolen, Masatoshi Koga, Kazunori Toyoda, Felix Fluri, Thanh G Phan, Velandai K Srikanth, Ji Hoe Heo, Hee-Joon Bae, Peter J Kelly, Toshio Imaizumi, Julie Staals, Sebastian Köhler, Yusuke Yakushiji, Dilek Necioglu Orken, Eric E Smith, Joanna M Wardlaw, Francesca M Chappell, Stephen D Makin, Jean-Louis Mas, David Calvet, Régis Bordet, Christopher P Chen, Roland Veltkamp, Nagaendran Kandiah, Robert J Simister, Frank-Erik De Leeuw, Stefan T Engelter, Nils Peters, Yannie O Soo, Annaelle Zietz, Jeroen Hendrikse, Werner H Mess, David J Werring, Joan Marti-Fabregas
BACKGROUND AND OBJECTIVES: The association between statin use and the risk of intracranial hemorrhage (ICrH) following ischemic stroke (IS) or transient ischemic attack (TIA) in patients with cerebral microbleeds (CMBs) remains uncertain. This study investigated the risk of recurrent IS and ICrH in patients receiving statins based on the presence of CMBs. METHODS: We conducted a pooled analysis of individual patient data from the Microbleeds International Collaborative Network, comprising 32 hospital-based prospective studies fulfilling the following criteria: adult patients with IS or TIA, availability of appropriate baseline MRI for CMB quantification and distribution, registration of statin use after the index stroke, and collection of stroke event data during a follow-up period of ≥3 months...
April 9, 2024: Neurology
#31
JOURNAL ARTICLE
Ashna Talwar, Satabdi Chatterjee, Jeffrey Sherer, Susan Abughosh, Michael Johnson, Rajender R Aparasu
BACKGROUND: Cumulative anticholinergic burden refers to the cumulative effect of multiple medications with anticholinergic properties. However, concomitant use of cholinesterase inhibitors (ChEIs) and anticholinergic burden can nullify the benefit of the treatment and worsen Alzheimer's disease (AD). A literature gap exists regarding the extent of the cumulative anticholinergic burden and associated risk factors in AD. Therefore, this study evaluated the prevalence and predictors of cumulative anticholinergic burden among patients with AD initiating ChEIs...
March 11, 2024: Drugs & Aging
#32
JOURNAL ARTICLE
Han Shi, Yuan Yuan, Xue Li, Yan-Fang Li, Ling Fan, Xue-Mei Yang
BACKGROUND: In China, the prevalence of type 2 diabetes mellitus (T2DM) among diabetic patients is estimated to be between 90%-95%. Additionally, China is among the 22 countries burdened by a high number of tuberculosis cases, with approximately 4.5 million individuals affected by active tuberculosis. Notably, T2DM poses a significant risk factor for the development of tuberculosis, as evidenced by the increased incidence of T2DM coexisting with pulmonary tuberculosis (T2DM-PTB), which has risen from 19...
February 15, 2024: World Journal of Diabetes
#33
JOURNAL ARTICLE
Priya S Kishnani, Gabriel Ángel Martos-Moreno, Agnès Linglart, Anna Petryk, Andrew Messali, Shona Fang, Cheryl Rockman-Greenberg, Keiichi Ozono, Wolfgang Högler, Lothar Seefried, Kathryn M Dahir
BACKGROUND: Hypophosphatasia (HPP) is a rare inherited disease caused by deficient activity of tissue-nonspecific alkaline phosphatase. Many adults with HPP have a high burden of disease, experiencing chronic pain, fatigue, limited mobility, and dental issues, contributing to decreased health-related quality of life (HRQoL). HPP may be treated with the enzyme replacement therapy asfotase alfa though real-world data in adults are limited. This analysis was conducted to assess the clinical effectiveness of asfotase alfa among adults in the Global HPP Registry...
March 8, 2024: Orphanet Journal of Rare Diseases
#34
JOURNAL ARTICLE
Fei Wang, Yangfei Xue, Yanqun Pei, Meng Yin, Zhepeng Sun, Zihui Zhou, Jing Liu, Qun Liu
BACKGROUND: Neospora caninum is an apicomplexan parasite that is particularly responsible for abortions in cattle and neuromuscular disease in dogs. Due to the limited effectiveness of currently available drugs, there is an urgent need for new therapeutic approaches to control neosporosis. Luciferase-based assays are potentially powerful tools in the search for antiprotozoal compounds, permitting the development of faster and more automated assays. The aim of this study was to construct a luciferase-expressing N...
March 8, 2024: Parasites & Vectors
#35
JOURNAL ARTICLE
Mehlika Toy, Begüm Güler, Kayra Somay, Genco Gençdal, Cihan Yurdaydin
OBJECTIVES: Hepatitis delta virus (HDV) infection has been granted orphan disease status by the US Food and Drug Administration and the European Medicines Agency owing to its rarity and relatively limited research and treatment options. Turkey is considered an endemic country for the virus. We aimed to provide a current and updated country- and region-specific HDV infection prevalence. METHODS: In this meta-analysis, we searched databases, including MEDLINE, PUBMED, EMBASE, and UlakBim (Turkish Medical Index) published between January 1, 2006, and December 31, 2022...
March 2024: IJID Reg
#36
JOURNAL ARTICLE
Dédée F Murrell, Pascal Joly, Victoria P Werth, Hideyuki Ujiie, Margitta Worm, Aaron R Mangold, Elena Avetisova, Jennifer Maloney, Elizabeth Laws, Eric Mortensen, Ariane Dubost-Brama, Arsalan Shabbir
BACKGROUND: Bullous pemphigoid (BP) is a rare, autoimmune, blistering skin disease associated with high disease burden, profoundly decreased quality of life and increased morbidity. Emerging evidence supports an important role for type 2 inflammation in disease pathogenesis. Current management relies on topical and/or systemic corticosteroids, non-selective immunosuppressants and antibiotics with anti-inflammatory properties, which are all limited by side effects and toxicities. Therefore, targeted, efficacious and safe therapies are needed...
March 5, 2024: Advances in Therapy
#37
JOURNAL ARTICLE
Anna C Hearps, Nikil Vootukuru, Salimeh Ebrahimnezhaddarzi, Brendan L Harney, Irene Boo, Long Nguyen, Damian Pavlyshyn, Paul M Dietze, Heidi E Drummer, Alexander J Thompson, Anthony Jaworowski, Margaret E Hellard, Rachel Sacks-Davis, Joseph S Doyle
BACKGROUND: Hepatitis C virus (HCV) infections are more prevalent in people who inject drugs (PWID) who often experience additional health risks. HCV induces inflammation and immune alterations that contribute to hepatic and non-hepatic morbidities. It remains unclear whether curative direct acting antiviral (DAA) therapy completely reverses immune alterations in PWID. METHODS: Plasma biomarkers of immune activation associated with chronic disease risk were measured in HCV-seronegative (n=24) and HCV RNA+ (n=32) PWID at baseline and longitudinally after DAA therapy...
2024: Frontiers in Immunology
#38
REVIEW
Mirza Muhammad Faran Ashraf Baig, Lee Ki Wong, Abdul Wasy Zia, Hongkai Wu
Rheumatoid Arthritis (RA) is an autoimmune disorder that hinders the normal functioning of bones and joints and reduces the quality of human life. Every year, millions of people are diagnosed with RA worldwide, particularly among elderly individuals and women. Therefore, there is a global need to develop new biomaterials, medicines and therapeutic methods for treating RA. This will improve the Healthcare Access and Quality Index and also relieve administrative and financial burdens on healthcare service providers at a global scale...
February 2024: Asian journal of pharmaceutical sciences
#39
JOURNAL ARTICLE
Keziah Cook, Deepshekhar Gupta, Yunjuan Liu, Chris Miller-Rosales, Fangzhou Wei, Edward Tuttle, Steven C Katz, Richard Marshak, Alexander Y Kim
Objectives: Pressure-Enabled Drug Delivery (PEDD), a method using pressure to advance catheter-delivered drug distribution, can improve treatment for hepatocellular carcinoma (HCC) and liver metastases, but real-world evidence is limited. We compared baseline patient characteristics, clinical complexity, and post-procedure healthcare resource utilization (HRUs) and clinical complications for PEDD and non-PEDD procedures. Methods: This study used a retrospective, longitudinal, cohort design of claims data from Clarivate's Real World Data Repository, which includes 98% of US payers with over 300 million unique patients from all US states...
February 28, 2024: Current Medical Research and Opinion
#40
JOURNAL ARTICLE
João Grade Santos, Mariana Martinho, Bárbara Ferreira, Diogo Cunha, Alexandra Briosa, Rita Miranda, Sofia Almeida, Hélder Pereira, Luís Brandão
BACKGROUND: Atrioventricular block (AVB) secondary to transient causes can recover with its correction. However, studies assessing predictors of recovery and long-term recurrence are lacking. METHODS: Patients with advanced or complete AVB who had a reversible cause admitted in a single expert center were retrospectively studied. Patients with AVB secondary to acute coronary syndromes were excluded from analysis. RESULTS: In a population of 162 patients, the main factors associated with recovery of rhythm without a permanent pacemaker (PPM) implantation were the presence of chronic kidney disease (CKD) on dialysis (OR 7...
February 26, 2024: Pacing and Clinical Electrophysiology: PACE
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